CN108490597A - A kind of confocal microscope system based on fiber coupler - Google Patents
A kind of confocal microscope system based on fiber coupler Download PDFInfo
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- CN108490597A CN108490597A CN201810568893.8A CN201810568893A CN108490597A CN 108490597 A CN108490597 A CN 108490597A CN 201810568893 A CN201810568893 A CN 201810568893A CN 108490597 A CN108490597 A CN 108490597A
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- 239000000835 fiber Substances 0.000 title claims abstract description 75
- 230000001427 coherent effect Effects 0.000 claims abstract description 40
- 230000008878 coupling Effects 0.000 claims abstract description 39
- 238000010168 coupling process Methods 0.000 claims abstract description 39
- 238000005859 coupling reaction Methods 0.000 claims abstract description 39
- 238000003384 imaging method Methods 0.000 claims abstract description 39
- 239000000523 sample Substances 0.000 claims abstract description 39
- 239000013307 optical fiber Substances 0.000 claims description 11
- 238000001514 detection method Methods 0.000 claims description 8
- 230000003287 optical effect Effects 0.000 claims description 7
- 210000000214 mouth Anatomy 0.000 description 6
- 230000002485 urinary effect Effects 0.000 description 4
- 238000005516 engineering process Methods 0.000 description 3
- 238000004043 dyeing Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- 239000000571 coke Substances 0.000 description 1
- 238000007334 copolymerization reaction Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 230000005611 electricity Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000001747 pupil Anatomy 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 238000009738 saturating Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
Classifications
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- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B21/00—Microscopes
- G02B21/0004—Microscopes specially adapted for specific applications
- G02B21/002—Scanning microscopes
- G02B21/0024—Confocal scanning microscopes (CSOMs) or confocal "macroscopes"; Accessories which are not restricted to use with CSOMs, e.g. sample holders
- G02B21/0032—Optical details of illumination, e.g. light-sources, pinholes, beam splitters, slits, fibers
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- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Microscoopes, Condenser (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
Abstract
The present invention provides a kind of confocal microscope system based on fiber coupler, including light source, optic fiber coupling unit, scanning element, micro-imaging unit and probe unit；The coherent light is transmitted to the optic fiber coupling unit by light source for generating coherent light；Optic fiber coupling unit is used to the coherent light being transmitted to the scanning element, and the reflected light or fluorescence that scanning element returns are transmitted to the probe unit；The scanning element is for receiving the coherent light and be transmitted to the micro-imaging unit, receiving the reflected light or fluorescence that the micro-imaging unit returns and being transmitted to the optic fiber coupling unit；The micro-imaging unit is used to the coherent light gathering sample surfaces, and the reflected light of sample or fluorescence are transmitted to the scanning element；The probe unit is for collecting the reflected light or fluorescence.The host machine parts such as laser, detector and scanning, microscopic imaging part are separated by fiber coupler, reduce the time of sufferer waiting.
Description
Technical field
The present invention relates to micro-imaging technique fields, aobvious more particularly, to a kind of copolymerization coke based on fiber coupler
Micro-system.
Background technology
The light microscope of being a highly integrated of laser confocal microscope has in the Senile Mouse of bioscience
Epochmaking status.Its basic principle is to eliminate stray light other than focus using confocal technology using laser as light source
Interference, greatly improves resolution ratio.Three-dimensional imaging and optical section may be implemented using fast scan imaging and Z axis stepping.
Laser Scanning Confocal Microscope increases laser scanning device on the basis of micro-imaging, by laser, electronics, computer graphic
As combined advanced Cell. Mol analytical instrument such as technologies.On the basis of conventional optical microscope, swash
Light Laser Scanning Confocal Microscope uses laser as light source, using confocal principle and device, and utilizes computer graphics into line number
Word image procossing is observed, analysis and output.The characteristics of Laser Scanning Confocal Microscope is can to carry out tomoscan to sample once to think, to thin
Born of the same parents' three-D space structure carries out lossless observation.
But it is complicated due to Laser Scanning Confocal Microscope system, size is excessively huge, it is difficult in the group to patient of body
It knits and is observed in real time.Conventional detection method is will to organize to carry out case detection after being sampled dyeing in hospital.This inspection
Flow gauge takes too long in time, and bigger burden is caused to patient.
Invention content
The present invention provides a kind of one kind for overcoming the above problem or solving the above problems at least partly and is based on optical fiber coupling
The confocal microscope system of clutch solves the complicated of Laser Scanning Confocal Microscope system in the prior art, and size is excessively huge,
It is difficult to the problem of the tissue to patient of body is observed in real time.
According to an aspect of the present invention, a kind of confocal microscope system based on fiber coupler is provided, including light source,
Optic fiber coupling unit, scanning element, micro-imaging unit and probe unit；
The coherent light is transmitted to the optic fiber coupling unit by the light source for generating coherent light；
The optic fiber coupling unit is used to the coherent light being transmitted to the scanning element, and scanning element is returned
Reflected light or fluorescence are transmitted to the probe unit；
The scanning element carries out two-dimensional scan for the dry light of automatic phasing, receives the coherent light and is transmitted to described aobvious
Micro- imaging unit receives the reflected light or fluorescence that the micro-imaging unit returns and is transmitted to the optic fiber coupling unit；
The micro-imaging unit is used to the coherent light gathering sample surfaces, and by the reflected light or fluorescence of sample
It is transmitted to the scanning element；
The probe unit finally exists for collecting the reflected light or fluorescence and converting optical signal into digital signal
Digital picture is arranged as in computer.
Preferably, the scanning element is 2-D vibration mirror or micro-electromechanical system (MEMS) scanning mirror.
Preferably, the scanning element includes the first speculum and the second speculum, first speculum and institute
The second speculum orthogonal arrangement is stated, first speculum is connected with first motor, and second speculum is connected with the second electricity
Machine；First speculum, second speculum respectively the first motor, the second motor drive under according to default rail
Mark is swung, and is scanned with the coherent light transmitted to the optic fiber coupling unit.
Preferably, the optic fiber coupling unit is m × n fiber couplers, and m >=1, n >=2.
Preferably, the optic fiber coupling unit be Single-Mode Fiber Coupling fiber coupler or single mode optical fiber with it is more
The fiber coupler that the fiber coupler or doubly clad optical fiber of mode fiber coupling are coupled with multimode fibre.
Preferably, the optic fiber coupling unit includes at least first interface, second interface and third interface；Described
One interface is for receiving the coherent light and being transmitted to the third interface；The third interface is used for the relevant optical transport
It is transmitted to the second interface to the scanning element, and by the reflected light or fluorescence that scanning element returns；The second interface
For coupleeing the reflected light or fluorescence to the probe unit.
Preferably, the micro-imaging unit includes scanning lens, condenser lens and object lens；The scanning lens and
The condenser lens forms relay system, for receiving the coherent light and the coherent light being converged to the object lens；It is described
The fluorescence that object lens are used to focusing to sample, and collecting the reflected light of sample or send out the coherent light.
It is combined preferably, the light source is single wavelength laser or multiple lasers.
Preferably, the probe unit is point probe or one-dimensional detectors or two-dimensional array detector.
The present invention proposes a kind of confocal microscope system based on fiber coupler, by fiber coupler by laser, visit
Host machine parts and scanning, the microscopic imaging parts such as device is surveyed to separate, it can be effective to extend by microscopic imaging part as hand-held device
The flexibility of micro imaging system and Clinical practicability, body in real time to the positions such as sufferer skin, oral cavity, urinary system into
Row real time imagery reduces the time of sufferer waiting.
Description of the drawings
Fig. 1 is the confocal microscope system structural schematic diagram based on fiber coupler according to the embodiment of the present invention.
Specific implementation mode
With reference to the accompanying drawings and examples, the specific implementation mode of the present invention is described in further detail.Implement below
Example is not limited to the scope of the present invention for illustrating the present invention.
When doctor observes the tissue of patient by Laser Scanning Confocal Microscope system, the tissue to patient is generally required
After being sampled, dyeing, by Laser Scanning Confocal Microscope system again to going sampling sample to carry out case detection, this detection can not
It realizes and real time imagery is carried out to positions such as sufferer skin, oral cavity, urinary systems in real time in body, and testing process consumes in time
Shi Taijiu causes patient bigger burden,
Therefore, a kind of confocal microscope system based on fiber coupler is provided in the present embodiment, as shown in Figure 1, packet
Include light source 1, optic fiber coupling unit 2, scanning element 3, micro-imaging unit 4 and probe unit 5；
The coherent light is transmitted to the optic fiber coupling unit 2 by the light source 1 for generating coherent light；
The optic fiber coupling unit 2 is used to the coherent light being transmitted to the scanning element 3, and scanning element 3 passes to again
It is transmitted to the detection list to micro-imaging unit 4, and by reflected light or fluorescence that micro-imaging unit 4, scanning element 3 return
Member 5；The fiber core of optic fiber coupling unit 4 plays the role of total focusing-detection aperture simultaneously.
Scanning element 3, the scanning element 3 are set between the optic fiber coupling unit 2 and the micro-imaging unit 4, sweep
It retouches the dry light of the automatic phasing under the setting of program of unit 3 and carries out two-dimensional scan, the scanning element 3 is for receiving the coherent light
And it is transmitted to the micro-imaging unit 4, receive the reflected light or fluorescence that the micro-imaging unit 4 returns and is transmitted to described
Optic fiber coupling unit 2
The micro-imaging unit 4 is used to the coherent light gathering sample surfaces, and by the reflected light of sample or glimmering
Optical transport is to the scanning element 3；Specifically, in the present embodiment, the micro-imaging unit is handheld apparatus, can be for
User's remote detection.
The probe unit 5 is for collecting the reflected light or fluorescence.The probe unit 5 is for collecting the reflected light
Or fluorescence and digital signal is converted optical signal into, and it is finally arranged as digital picture in a computer.
In the present embodiment, probe unit 5 is also associated with computer, reflected light for being collected into probe unit 5 or
Fluorescence converted, is shown and analyzing processing.
In the present embodiment, by fiber coupler by the host machine parts such as laser, detector and scanning, microscopic imaging part
It separates, can effectively extend flexibility and the clinical practice of micro imaging system by microscopic imaging part as hand-held device
Property, real time imagery is carried out to positions such as sufferer skin, oral cavity, urinary systems in real time in body, reduces the time of sufferer waiting.
As a preferred embodiment, the scanning element 3 is 2-D vibration mirror or micro-electromechanical system (MEMS) scanning mirror.
As a preferred embodiment, the optic fiber coupling unit 2 is the fiber coupler of Single-Mode Fiber Coupling, or
The fiber coupler that the fiber coupler or doubly clad optical fiber that single mode optical fiber is coupled with multimode fibre are coupled with multimode fibre.
As a preferred embodiment, the optic fiber coupling unit 2 includes at least first interface, second interface and the
Three interfaces；The first interface is for receiving the coherent light and being transmitted to the third interface；The third interface is used for will
The coherent light is transmitted to the micro-imaging unit 4, and the reflected light that returns of micro-imaging unit 4 or fluorescence be transmitted to it is described
Second interface；The second interface is used to couple the reflected light or fluorescence to the probe unit 5.
As a preferred embodiment, the optic fiber coupling unit 2 is m × n fiber couplers, m >=1, n >=2.
In the present embodiment, as shown in fig. 1,2 × 2 fiber coupler of selection of optic fiber coupling unit 2, including A, B, C,
Tetra- interfaces of D, A mouthfuls receive the coherent light that be emitted from light source 1 and are transmitted to B mouthfuls, and the B mouths reception of optic fiber coupling unit 2 is by scanning
The reflected light or fluorescence and be coupled to D mouthfuls that unit 3 returns, and it is emitted to probe unit 5.
As a preferred embodiment, the scanning element 3 includes the first speculum and the second speculum, and described the
One speculum and the second speculum orthogonal arrangement, first speculum are connected with first motor, second speculum
It is connected with the second motor；First speculum, second speculum are respectively in the first motor, the drive of the second motor
Under swung according to desired guiding trajectory, be scanned with the coherent light transmitted to the optic fiber coupling unit 2.
In the present embodiment, the scanning element 3 by the two panels speculum group of orthogonal arrangement in the drive of respective motor
Lower two panels speculum can be swung according to preset track, be swept to the coherent light of the B mouths outgoing of optic fiber coupling unit 2
It retouches.In the present embodiment, the scanning element 3 can form integrated hand-held device with micro-imaging unit 4.
As a preferred embodiment, the micro-imaging unit 4 includes scanning lens 6, condenser lens 7 and object lens
8；The scanning lens 6 and the condenser lens 7 form relay system, for receiving the coherent light and converging the coherent light
Gather to the object lens 8；The object lens 8 are used to the coherent light focusing to sample, and collect the reflected light of sample or send out
Fluorescence.The micro-imaging unit 4 is made of scanning lens 6, condenser lens 7, object lens 8.Wherein scanning lens 6, convergence are saturating
Mirror 7 forms relay system, and the coherent light at scanning element 3 is relayed to the rear pupil of object lens 8.
As a preferred embodiment, the light source 1 is that single wavelength laser or multiple lasers combine, and also may be used
With other optical fiber combinations.
As a preferred embodiment, the probe unit 5 is point probe or one-dimensional detectors or two-dimensional array
Detector.
In conclusion the present invention proposes a kind of confocal microscope system based on fiber coupler, pass through fiber coupler
The host machine parts such as laser, detector and scanning, microscopic imaging part are separated, can by microscopic imaging part as hand-held device,
Effective flexibility and the Clinical practicability for extending micro imaging system, in body in real time to sufferer skin, oral cavity, urinary system
The positions such as system carry out real time imagery, reduce the time of sufferer waiting.
The embodiments such as the test equipment of display device described above are only schematical, wherein described as separation
The unit of part description may or may not be physically separated, the component shown as unit can be or
It can not be physical unit, you can be located at a place, or may be distributed over multiple network units.It can be according to reality
Border needs to select some or all of module therein to achieve the purpose of the solution of this embodiment.Those of ordinary skill in the art
In the case where not paying performing creative labour, you can to understand and implement.
Finally it should be noted that：The above various embodiments is only to illustrate the technical solution of the embodiment of the present invention rather than right
It is limited；Although the embodiment of the present invention is described in detail with reference to foregoing embodiments, the ordinary skill of this field
Personnel should understand that：It still can be with technical scheme described in the above embodiments is modified, or to which part
Or all technical features carries out equivalent replacement；And these modifications or replacements, it does not separate the essence of the corresponding technical solution
The range of each embodiment technical solution of the embodiment of the present invention.
Claims (9)
1. a kind of confocal microscope system based on fiber coupler, which is characterized in that including light source, optic fiber coupling unit, sweep
Retouch unit, micro-imaging unit and probe unit；
The coherent light is transmitted to the optic fiber coupling unit by the light source for generating coherent light；
The optic fiber coupling unit is used to the coherent light being transmitted to the scanning element, and the reflection that scanning element is returned
Light or fluorescence are transmitted to the probe unit；
The scanning element carries out two-dimensional scan for the dry light of automatic phasing, receive the coherent light and be transmitted to it is described it is micro- at
As unit, receives the reflected light or fluorescence that the micro-imaging unit returns and be transmitted to the optic fiber coupling unit；
The micro-imaging unit is used to the coherent light gathering sample surfaces, and the reflected light of sample or fluorescence are transmitted
To the scanning element；
The probe unit is finally being calculated for collecting the reflected light or fluorescence and converting optical signal into digital signal
Digital picture is arranged as in machine.
2. the confocal microscope system according to claim 1 based on fiber coupler, which is characterized in that the scanning is single
Member is 2-D vibration mirror or micro-electromechanical system (MEMS) scanning mirror.
3. the confocal microscope system according to claim 1 based on fiber coupler, which is characterized in that the scanning is single
Member includes the first speculum and the second speculum, first speculum and the second speculum orthogonal arrangement, and described first
Speculum is connected with first motor, and second speculum is connected with the second motor；First speculum, second reflection
Mirror respectively the first motor, the second motor drive under swing according to desired guiding trajectory, to be passed to the optic fiber coupling unit
Defeated coherent light is scanned.
4. the confocal microscope system according to claim 1 based on fiber coupler, which is characterized in that the optical fiber coupling
Conjunction unit is m × n fiber couplers, m >=1, n >=2.
5. the confocal microscope system according to claim 4 based on fiber coupler, which is characterized in that the optical fiber coupling
Close the fiber coupler that unit is Single-Mode Fiber Coupling or the fiber coupler that single mode optical fiber is coupled with multimode fibre or double-contracting
The fiber coupler that layer optical fiber is coupled with multimode fibre.
6. the confocal microscope system according to claim 1 based on fiber coupler, which is characterized in that the optical fiber coupling
It closes unit and includes at least first interface, second interface and third interface；The first interface is for receiving the coherent light and passing
Transport to the third interface；The third interface is used to the coherent light being transmitted to the scanning element, and by scanning element
The reflected light or fluorescence of return are transmitted to the second interface；The second interface is for coupling the reflected light or fluorescence to
The probe unit.
7. the confocal microscope system according to claim 1 based on fiber coupler, which is characterized in that it is described it is micro- at
As unit includes scanning lens, condenser lens and object lens；The scanning lens and the condenser lens form relay system, are used for
It receives the coherent light and the coherent light is converged into the object lens；The object lens are used to the coherent light focusing to sample
Product, and the fluorescence collected the reflected light of sample or sent out.
8. the confocal microscope system according to claim 1 based on fiber coupler, which is characterized in that the light source is
Single wavelength laser or the combination of multiple lasers.
9. the confocal microscope system according to claim 1 based on fiber coupler, which is characterized in that the detection is single
Member is point probe or one-dimensional detectors or two-dimensional array detector.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810568893.8A CN108490597A (en) | 2018-06-05 | 2018-06-05 | A kind of confocal microscope system based on fiber coupler |
| PCT/CN2019/090043 WO2019233425A1 (en) | 2018-06-05 | 2019-06-05 | Confocal microscopy system employing optical fiber coupler |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810568893.8A CN108490597A (en) | 2018-06-05 | 2018-06-05 | A kind of confocal microscope system based on fiber coupler |
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Cited By (7)
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| CN109407294A (en) * | 2018-12-07 | 2019-03-01 | 哈尔滨工业大学 | A kind of optical fiber fluorescence confocal microscopic imaging device and method |
| CN110248063A (en) * | 2019-06-24 | 2019-09-17 | 华中科技大学 | A kind of colored coherent imaging device and method for no lens microscopic system |
| WO2019233425A1 (en) * | 2018-06-05 | 2019-12-12 | Zhang Hongming | Confocal microscopy system employing optical fiber coupler |
| CN111239154A (en) * | 2020-01-18 | 2020-06-05 | 哈尔滨工业大学 | Transverse differential dark field confocal microscopic measurement device and method thereof |
| CN111239155A (en) * | 2020-01-18 | 2020-06-05 | 哈尔滨工业大学 | Axial differential dark field confocal microscopic measurement device and method thereof |
| WO2021051696A1 (en) * | 2019-12-24 | 2021-03-25 | 深圳市速腾聚创科技有限公司 | Fmcw lidar system |
| CN116982917B (en) * | 2023-09-19 | 2024-06-21 | 北京攸维医疗科技有限公司 | Endoscopic processing system based on fluorescence lifetime |
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| CN113595637B (en) | 2021-09-27 | 2022-01-25 | 清华大学 | Full-light sensing and calculation integrated light field intelligent processing system and method |
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| WO2019233425A1 (en) * | 2018-06-05 | 2019-12-12 | Zhang Hongming | Confocal microscopy system employing optical fiber coupler |
| CN109407294A (en) * | 2018-12-07 | 2019-03-01 | 哈尔滨工业大学 | A kind of optical fiber fluorescence confocal microscopic imaging device and method |
| CN110248063A (en) * | 2019-06-24 | 2019-09-17 | 华中科技大学 | A kind of colored coherent imaging device and method for no lens microscopic system |
| CN110248063B (en) * | 2019-06-24 | 2023-12-26 | 华中科技大学 | Color coherent imaging device and method for lens-free microscopic system |
| WO2021051696A1 (en) * | 2019-12-24 | 2021-03-25 | 深圳市速腾聚创科技有限公司 | Fmcw lidar system |
| CN113383246A (en) * | 2019-12-24 | 2021-09-10 | 深圳市速腾聚创科技有限公司 | FMCW laser radar system |
| CN113383246B (en) * | 2019-12-24 | 2024-02-27 | 深圳市速腾聚创科技有限公司 | FMCW laser radar system |
| CN111239154A (en) * | 2020-01-18 | 2020-06-05 | 哈尔滨工业大学 | Transverse differential dark field confocal microscopic measurement device and method thereof |
| CN111239155A (en) * | 2020-01-18 | 2020-06-05 | 哈尔滨工业大学 | Axial differential dark field confocal microscopic measurement device and method thereof |
| CN111239155B (en) * | 2020-01-18 | 2023-06-23 | 哈尔滨工业大学 | Axial differential dark field confocal microscopic measuring device and method thereof |
| CN116982917B (en) * | 2023-09-19 | 2024-06-21 | 北京攸维医疗科技有限公司 | Endoscopic processing system based on fluorescence lifetime |
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| WO2019233425A1 (en) | 2019-12-12 |
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