CN108403079A - A kind of confocal imaging system based on OCT - Google Patents
A kind of confocal imaging system based on OCT Download PDFInfo
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- CN108403079A CN108403079A CN201810161199.4A CN201810161199A CN108403079A CN 108403079 A CN108403079 A CN 108403079A CN 201810161199 A CN201810161199 A CN 201810161199A CN 108403079 A CN108403079 A CN 108403079A
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- 238000010226 confocal imaging Methods 0.000 title claims abstract description 26
- 238000012545 processing Methods 0.000 claims abstract description 27
- 230000002452 interceptive effect Effects 0.000 claims abstract description 25
- 239000013307 optical fiber Substances 0.000 claims abstract description 20
- 238000003384 imaging method Methods 0.000 claims description 10
- 239000000835 fiber Substances 0.000 claims description 5
- 241000208340 Araliaceae Species 0.000 claims description 2
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 claims description 2
- 235000003140 Panax quinquefolius Nutrition 0.000 claims description 2
- 230000008878 coupling Effects 0.000 claims description 2
- 238000010168 coupling process Methods 0.000 claims description 2
- 238000005859 coupling reaction Methods 0.000 claims description 2
- 235000008434 ginseng Nutrition 0.000 claims description 2
- 230000003287 optical effect Effects 0.000 claims 2
- 230000005855 radiation Effects 0.000 claims 1
- 238000000034 method Methods 0.000 abstract description 6
- 238000012937 correction Methods 0.000 abstract description 2
- 238000002059 diagnostic imaging Methods 0.000 abstract description 2
- 238000012014 optical coherence tomography Methods 0.000 description 22
- 230000008520 organization Effects 0.000 description 8
- 238000006243 chemical reaction Methods 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 230000003595 spectral effect Effects 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 238000013075 data extraction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000005693 optoelectronics Effects 0.000 description 1
- 230000005622 photoelectricity Effects 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/102—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for optical coherence tomography [OCT]
Abstract
The present invention relates to medical imaging techniques fields, disclose a kind of confocal imaging system based on OCT.A kind of confocal imaging system based on OCT provided by the invention, including OCT light source, beam treatment unit, reference arm, reference mirror, sample arm, sample, optical fiber splitter, the first signal processing module, second signal processing module and computer.The present invention passes through in traditional OCT systems, increase optical fiber splitter behind beam treatment unit, the interfering beam come out from beam treatment unit is divided into two, divide on a part of light to photodetector, transverse cross-sectional view is obtained by processing, since the transverse cross-sectional view and longitudinal sectional drawing of sample are to handle to obtain via the same interfering beam, therefore the transverse cross-sectional view of obtained sample and longitudinal sectional drawing are to correspond completely in position, and position correction is done to this two figures without the later stage.Meanwhile the sample rate of photodetector is fast, it can be with Quick Acquisition eyeground transverse cross-sectional view.
Description
Technical field
The present invention relates to medical imaging techniques fields, more particularly to a kind of confocal imaging system based on OCT.
Background technology
OCT (Optical Coherence Tomography, means of optical coherence tomography) imagings are from ultrasound
Wave imaging technique, the characteristics of combining low coherence interference and confocal micro-measurement, scatter the phase delay of light wave by detection, from
Scattering light at organic organization's different depth with refer to the interference of light, to detect the reflection depth corresponding to phase delay, then
Scanned by light beam, signal conversion, data extraction and etc. obtain the tomograph of organic organization, that is, the longitudinal direction of organic organization
Sectional view, thus the case where judging tested organic organization according to tomograph.Usually obtain organic organization tomograph it
Before, it is also necessary to obtain the transverse cross-sectional view for being tested organic organization, judged by transverse cross-sectional view tested organic organization need into
The position of row fault imaging.
Currently, the transverse cross-sectional view and longitudinal sectional drawing of traditional tested organic organization are to separate to measure, due to measuring
Instrument, the influence of the factors such as measuring environment, transverse cross-sectional view and longitudinal sectional drawing needs are adjusted after imaging, could realize cross
To corresponding for sectional view and longitudinal sectional drawing.
Invention content
The present invention is directed to disadvantages mentioned above in the prior art, provides a kind of confocal imaging system based on OCT, solves
In traditional OCT image, transverse cross-sectional view and longitudinal sectional drawing are the problems for separating imaging so as to cause imaging results inaccuracy.
In order to solve the above-mentioned technical problem, the present invention is addressed by following technical proposals：
A kind of confocal imaging system based on OCT, including OCT light source, beam treatment unit, reference arm, reference mirror, sample
Arm, sample, optical fiber splitter, the first signal processing module, second signal processing module and computer；
The OCT light source sends out the first light beam, and the beam treatment unit point first light beam is the second light beam and the
Three light beams, second light beam reach the reference mirror by the reference arm, and the third light beam is arrived by the sample arm
Up to sample；
Second light beam reflects to form reference beam by reference mirror along former input path, and the third light beam passes through quilt
Sample reflects to form signal beams along former input path, and the reference beam and the signal beams pass through the beam treatment
Unit couples to form interfering beam；
The interfering beam is divided into the first interfering beam and the second interfering beam, first interference by optical fiber splitter
Light beam forms the first data flow by first signal processing module, and second interfering beam is by the second signal
It manages module and forms the second data flow；
First data flow samples to form the first image by the computer, described in the second data flow process
Computer samples to form the second image.
Further, first signal processing module includes photodetector.
Further, the second signal processing module includes spectrometer.
Further, the confocal imaging system further includes collimation lens, and the collimation lens is for respectively by described the
Two light beams and third light beam are converted to collimated light beam by a light beam.
Further, the confocal imaging system further includes the first galvanometer and the second galvanometer, first galvanometer and second
Galvanometer is used to control the incident direction that the third light beam injects sample, and then carries out two-dimensional scan to sample.
Further, the confocal imaging system further includes galvanometer control unit, and the galvanometer control unit is for controlling
The rotation of first galvanometer and the second galvanometer, the galvanometer control unit includes vibrating mirror driver.
Further, the OCT light source is super-radiance light emitting diode, and the beam treatment unit is fiber coupler,
The optical fiber splitter is y-type optical fiber.
Further, the sample is human eye, and first image is fundus imaging figure, second image
For eyeground tomograph.
Compared with prior art, the beneficial effects of the present invention are：
1., will be from beam treatment list by increasing optical fiber splitter behind beam treatment unit in traditional OCT systems
The interfering beam of member out is divided into two, and on point a part of light to photodetector, transverse cross-sectional view is obtained by processing, due to
The transverse cross-sectional view and longitudinal sectional drawing of sample are to handle to obtain via the same interfering beam, therefore the transverse direction of obtained sample is cutd open
Face figure and longitudinal sectional drawing are to correspond completely in position, and position correction is done to this two figures without the later stage；Also, due to
The acquisition of two figures is to use same light path, and compared to the existing method for obtaining transverse cross-sectional view, system provided by the invention obtains
It is low to obtain extra charge caused by transverse cross-sectional view, more economically.
2. the signal that the hot spot and spectrometer that are formed on sample due to OCT light source receive, is a confocal system,
So the signal that hot spot and photodetector that OCT light source is formed on sample receive is also a confocal system, so
Compared to the transverse cross-sectional view that conventional method obtains, the picture quality higher of transverse cross-sectional view provided by the invention.
3. compared to the existing method for obtaining transverse cross-sectional view, the present invention adopts interfering beam using photodetector
Collection, picking rate is fast, and at the same time in scanning range, the present invention can provide the transverse cross-sectional view of higher resolution.
4. it can judge the stability of layout of OCT systems by being detected to the signal that photodetector obtains, it is right
Traditional OCT systems provide a kind of detection means of new stabilization of equipment performance.
Invention is further described in detail with reference to the accompanying drawings and detailed description.
Description of the drawings
Fig. 1 is the system schematic of the present invention；
Fig. 2 is the index path of this system.
In figure：1, OCT light source；2, beam treatment unit；3, optical fiber splitter；4, the first signal processing module；41, photoelectricity
Detector；5, second signal processing module；51, spectrometer；8, computer；9, galvanometer control unit；10, galvanometer unit；101、
First galvanometer；102, the second galvanometer；11, collimation lens；12, reference mirror；13, sample；20, reference arm；30, sample arm；
A, the first light beam；B, the second light beam；C, reference beam；D, third light beam；F, signal beams；G, interfering beam；H, the first interference
Light beam；I, the second interfering beam；J, the first data flow；K, the second data flow.
Specific implementation mode
In the following, in conjunction with attached drawing and specific implementation mode, the present invention is described further, it should be noted that not
Under the premise of conflicting, new implementation can be formed between various embodiments described below or between each technical characteristic in any combination
Example.
As shown in Figure 1 and Figure 2, a kind of confocal imaging system based on OCT, including OCT light source 1, beam treatment unit 2, ginseng
Examine arm 20, reference mirror 12, sample arm 30, sample 13, optical fiber splitter 3, the first signal processing module 4, at second signal
Manage module 5 and computer 8；
OCT light source 1 sends out the first light beam A, and beam treatment unit 2 divides the first light beam A to be the second light beam B and third light beam D,
Second light beam B reaches reference mirror 12 by reference arm 20, and third light beam D reaches sample 13 by sample arm 30；
Second light beam B reflects to form reference beam C by reference mirror 12 along former input path, namely along reference arm 20, the
Three light beam D reflect to form signal beams F, reference beam C and letter by sample 13 along former input path namely sample arm 30
Number light beam F forms interfering beam G by the coupling of beam treatment unit 2；
Interfering beam G divides by optical fiber splitter 3 for the first interfering beam H and the second interfering beam I, the first interfering beam
H forms the first data flow J, the second interfering beam I by the first signal processing module 4 and is formed by second signal processing module 5
Second data flow K；
First data flow J forms the first image, that is, the horizontal section of sample 13 by the sampling of computer 8
Figure.Second data flow through K and cross sampling the second image of formation of computer 8, that is, the longitudinal sectional drawing of sample 13.
First signal processing module 4 includes photodetector 41 and the first signal processing unit, second signal processing module 5
Including spectrometer 51 and second signal processing unit.Photodetector is usually photoelectric diode, avalanche optoelectronic diode or light
Electric multiplier tube etc..The first interfering beam H that photodetector 41 is used to acquire is converted to electric signal, subsequent first signal processing
Unit is amplified transformed electric signal, filters, analog-to-digital conversion process；The second interference light that spectrometer 51 is used to acquire
Beam I is separated into spectral signal by polychromatic light, and second signal processing unit is used to carry out Fourier transformation processing to spectral signal.
Confocal imaging system further includes collimation lens 11, and collimation lens 11 is used for respectively by the second light beam B and third light beam D
Collimated light beam is converted to by a light beam.Further include galvanometer unit 10, galvanometer unit 10 includes the first galvanometer 101 and the second galvanometer
102, the first galvanometer 101 and the second galvanometer 102 are used to control the incident direction that third light beam D injects sample 13, and then right
Sample 13 carries out two-dimensional scan.
Confocal imaging system further includes galvanometer control unit 9, and galvanometer control unit 9 is for controlling the first galvanometer 101 and the
The rotation of two galvanometers 102, galvanometer control unit 9 include vibrating mirror driver, and vibrating mirror driver receives instruction from computer 8, according to
The direction of rotation of order-driven the first galvanometer 101 and the second galvanometer 102, and then control third light beam D and inject sample 13
Incident direction.
OCT light source 1 is super-radiance light emitting diode, the fiber coupler that beam treatment unit 2 is 2 × 2, optical fiber splitter
3 be the y-type optical fiber of one-to-two.
This system can be applied to the imaging of the multiple fields such as ophthalmology, skin, gastrointestinal tract.In the present embodiment, sample
13 be human eye, and the first image is fundus imaging figure, and the second image is eyeground tomograph.
The OCT light source 1 of this system can also use swept light source, when using swept light source, second signal processing
Spectrometer 51 in module 5 is replaced into photodetector 41.
System work when, the first image and the second tomograph can be acquired simultaneously, once can also only acquire first at
As figure or the second image, in the case where only needing a figure that can be judged to sample 13, only acquisition first
Image or the second image, speed are faster, more efficient.
The above embodiment is only the preferred embodiment of the present invention, and the scope of protection of the present invention is not limited thereto,
The variation and replacement for any unsubstantiality that those skilled in the art is done on the basis of the present invention belong to institute of the present invention
Claimed range.
Claims (10)
1. a kind of confocal imaging system based on OCT, which is characterized in that including OCT light source, beam treatment unit, reference arm, ginseng
Examine mirror, sample arm, sample, optical fiber splitter, the first signal processing module, second signal processing module and computer；
The OCT light source sends out the first light beam, and the beam treatment unit point first light beam is the second light beam and third light
Beam, second light beam reach the reference mirror by the reference arm, and the third light beam reaches quilt by the sample arm
Sample；
Second light beam reflects to form reference beam by reference mirror along former input path, and the third light beam passes through detected sample
Product reflect to form signal beams along former input path, and the reference beam and the signal beams pass through the beam treatment unit
Coupling forms interfering beam；
The interfering beam is divided into the first interfering beam and the second interfering beam, first interfering beam by optical fiber splitter
The first data flow is formed by first signal processing module, second interfering beam handles mould by the second signal
Block forms the second data flow；
First data flow samples to form the first image by the computer, and second data flow passes through the calculating
Machine samples to form the second image.
2. the confocal imaging system based on OCT as described in claim 1, which is characterized in that first signal processing module
Including photodetector.
3. the confocal imaging system based on OCT as described in claim 1, which is characterized in that the second signal processing module
Including spectrometer.
4. the confocal imaging system based on OCT as described in claims 1 or 2 or 3, which is characterized in that the confocal imaging system
System further includes collimation lens, and the collimation lens is used to respectively be converted to second light beam and third light beam by a light beam flat
Row light beam.
5. the confocal imaging system based on OCT as claimed in claim 4, which is characterized in that the confocal imaging system also wraps
The first galvanometer and the second galvanometer are included, first galvanometer and the second galvanometer are used to control the third light beam and inject sample
Incident direction, and then two-dimensional scan is carried out to sample.
6. the confocal imaging system based on OCT as claimed in claim 5, which is characterized in that the confocal imaging system also wraps
Galvanometer control unit is included, the galvanometer control unit is used to control the rotation of first galvanometer and the second galvanometer, the galvanometer
Control unit includes vibrating mirror driver.
7. the confocal imaging system based on OCT as described in claims 1 or 2 or 3, which is characterized in that the OCT light source is super
Radiation light emitting diode, the beam treatment unit are fiber coupler, and the optical fiber splitter is y-type optical fiber.
8. the confocal imaging system based on OCT as claimed in claim 4, which is characterized in that the OCT light source is sent out for superradiance
Optical diode, the beam treatment unit are fiber coupler, and the optical fiber splitter is y-type optical fiber.
9. the confocal imaging system based on OCT as claimed in claim 5, which is characterized in that the OCT light source is sent out for superradiance
Optical diode, the beam treatment unit are fiber coupler, and the optical fiber splitter is y-type optical fiber.
10. the confocal imaging system based on OCT as described in claims 1 or 2 or 3, which is characterized in that the sample is
Human eye, first image are fundus imaging figure, and second image is eyeground tomograph.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201810161199.4A CN108403079A (en) | 2018-02-26 | 2018-02-26 | A kind of confocal imaging system based on OCT |
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| CN201810161199.4A CN108403079A (en) | 2018-02-26 | 2018-02-26 | A kind of confocal imaging system based on OCT |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109330558A (en) * | 2018-09-29 | 2019-02-15 | 执鼎医疗科技（杭州）有限公司 | For increasing the OCT system of fundus imaging range |
| CN110801206A (en) * | 2019-11-18 | 2020-02-18 | 佛山光微科技有限公司 | Image correction method of high-resolution optical coherence confocal microscope |
| CN113432527A (en) * | 2021-07-23 | 2021-09-24 | 中国科学院电工研究所 | High-speed spectral domain optical coherence tomography system based on Mach-Zehnder interferometer |
Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5465147A (en) * | 1991-04-29 | 1995-11-07 | Massachusetts Institute Of Technology | Method and apparatus for acquiring images using a ccd detector array and no transverse scanner |
| CN1694644A (en) * | 2002-06-28 | 2005-11-09 | Oti眼技术股份有限公司 | Optical mapping apparatus with adjustable depth resolution and multiple functionality |
| GB0522340D0 (en) * | 2005-11-02 | 2005-12-07 | Oti Ophthalmic Technologies | En-face oct with parallel detector array |
| US20120327423A1 (en) * | 2011-06-23 | 2012-12-27 | Nidek Co., Ltd. | Optical coherence tomography apparatus |
| WO2014188946A1 (en) * | 2013-05-24 | 2014-11-27 | 国立大学法人筑波大学 | Jones matrix oct system and program for carrying out image processing on measured data obtained by said oct |
| CN105167766A (en) * | 2015-11-03 | 2015-12-23 | 深圳市斯尔顿科技有限公司 | Blood flow measuring device and blood flow measuring method |
| WO2017073414A1 (en) * | 2015-10-29 | 2017-05-04 | 株式会社トプコン | Ophthalmological imaging device |
| CN208693252U (en) * | 2018-02-26 | 2019-04-05 | 执鼎医疗科技（杭州）有限公司 | A kind of confocal imaging system based on OCT |
-
2018
- 2018-02-26 CN CN201810161199.4A patent/CN108403079A/en active Pending
Patent Citations (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5465147A (en) * | 1991-04-29 | 1995-11-07 | Massachusetts Institute Of Technology | Method and apparatus for acquiring images using a ccd detector array and no transverse scanner |
| CN1694644A (en) * | 2002-06-28 | 2005-11-09 | Oti眼技术股份有限公司 | Optical mapping apparatus with adjustable depth resolution and multiple functionality |
| GB0522340D0 (en) * | 2005-11-02 | 2005-12-07 | Oti Ophthalmic Technologies | En-face oct with parallel detector array |
| US20120327423A1 (en) * | 2011-06-23 | 2012-12-27 | Nidek Co., Ltd. | Optical coherence tomography apparatus |
| WO2014188946A1 (en) * | 2013-05-24 | 2014-11-27 | 国立大学法人筑波大学 | Jones matrix oct system and program for carrying out image processing on measured data obtained by said oct |
| WO2017073414A1 (en) * | 2015-10-29 | 2017-05-04 | 株式会社トプコン | Ophthalmological imaging device |
| CN105167766A (en) * | 2015-11-03 | 2015-12-23 | 深圳市斯尔顿科技有限公司 | Blood flow measuring device and blood flow measuring method |
| CN208693252U (en) * | 2018-02-26 | 2019-04-05 | 执鼎医疗科技（杭州）有限公司 | A kind of confocal imaging system based on OCT |
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109330558A (en) * | 2018-09-29 | 2019-02-15 | 执鼎医疗科技（杭州）有限公司 | For increasing the OCT system of fundus imaging range |
| CN110801206A (en) * | 2019-11-18 | 2020-02-18 | 佛山光微科技有限公司 | Image correction method of high-resolution optical coherence confocal microscope |
| CN110801206B (en) * | 2019-11-18 | 2022-04-26 | 佛山光微科技有限公司 | Image correction method of high-resolution optical coherence confocal microscope |
| CN113432527A (en) * | 2021-07-23 | 2021-09-24 | 中国科学院电工研究所 | High-speed spectral domain optical coherence tomography system based on Mach-Zehnder interferometer |
| CN113432527B (en) * | 2021-07-23 | 2022-07-12 | 中国科学院电工研究所 | High-speed spectral domain optical coherence tomography system based on Mach-Zehnder interferometer |
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