CN109008940A - A kind of OCT system of the confocal fundus imaging of multiple light courcess - Google Patents
A kind of OCT system of the confocal fundus imaging of multiple light courcess Download PDFInfo
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- CN109008940A CN109008940A CN201810745897.9A CN201810745897A CN109008940A CN 109008940 A CN109008940 A CN 109008940A CN 201810745897 A CN201810745897 A CN 201810745897A CN 109008940 A CN109008940 A CN 109008940A
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- 238000003384 imaging method Methods 0.000 title claims abstract description 29
- 239000000835 fiber Substances 0.000 claims description 8
- 230000002452 interceptive effect Effects 0.000 claims description 6
- 230000013011 mating Effects 0.000 claims description 2
- 230000005855 radiation Effects 0.000 claims 2
- 238000000034 method Methods 0.000 abstract description 4
- 238000002059 diagnostic imaging Methods 0.000 abstract description 2
- 230000011664 signaling Effects 0.000 abstract description 2
- 238000012014 optical coherence tomography Methods 0.000 description 37
- 230000008520 organization Effects 0.000 description 8
- 238000005259 measurement Methods 0.000 description 4
- 238000003745 diagnosis Methods 0.000 description 3
- 230000003287 optical effect Effects 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 239000013307 optical fiber Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000010226 confocal imaging Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000013534 fluorescein angiography Methods 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 150000002475 indoles Chemical class 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/102—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for optical coherence tomography [OCT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/0008—Apparatus for testing the eyes; Instruments for examining the eyes provided with illuminating means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/1025—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for confocal scanning
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/14—Arrangements specially adapted for eye photography
Abstract
The present invention relates to medical imaging techniques fields, disclose a kind of OCT system of confocal fundus imaging of multiple light courcess, including OCT light source, first light source, beam treatment unit, reference arm, reference mirror, sample arm, sample, long wave pass filter or short wave pass filter, the first signal processing module, second signal processing module and computer；OCT light source issues the first light beam, and the first light beam becomes the second light beam and the 5th light beam through beam treatment unit, and the second light beam reaches reference mirror by reference arm；5th light beam forms the 6th light beam by long wave pass filter or short wave pass filter, and the 6th light beam reaches sample by sample arm, and is reflected in the different depth of sample；In traditional OCT system, by accessing the light source of different wave length in total focal point, the acquisition of the signal of focal point is total to sample by the first signaling module, the acquisition of various fundus image may be implemented, and then provide diagnostic message more abundant for clinician.
Description
Technical field
The present invention relates to medical imaging techniques fields, more particularly to the OCT system of the confocal fundus imaging of multiple light courcess a kind of.
Background technique
OCT (Optical Coherence Tomography, means of optical coherence tomography) imaging is from ultrasound
Wave imaging technique, the characteristics of combining low coherence interference and confocal micro-measurement, by the phase delay of detection scattering light wave, from
Scattering light at organic organization's different depth with refer to the interference of light, to detect reflection depth corresponding to phase delay, then
Scanned by light beam, signal conversion, data extract and etc. obtain the tomograph of organic organization, that is, the longitudinal direction of organic organization
Sectional view, thus the case where judging tested organic organization according to tomograph.Usually obtain organic organization tomograph it
Before, it is also necessary to the transverse cross-sectional view for obtaining tested organic organization, judged by transverse cross-sectional view tested organic organization need into
The position of row tomographic imaging.
Currently, the transverse cross-sectional view and longitudinal sectional drawing of traditional tested organic organization are to separate measurement, due to measurement
Instrument, the influence of the factors such as measurement environment, transverse cross-sectional view and longitudinal sectional drawing needs are adjusted after imaging, are just able to achieve cross
To the reciprocal correspondence of sectional view and longitudinal sectional drawing.Also, in traditional OCT system, OCT light source is single, obtained tomograph
Type it is single, clinician's diagnosis basis is few, and when needing different tomograph as diagnosis basis, traditional OCT system is not
It is able to satisfy requirement.
Summary of the invention
For overcome the deficiencies in the prior art, the purpose of the present invention is to provide a kind of confocal fundus imagings of multiple light courcess
OCT system solves in traditional OCT image, the first image, that is, single problem of OCT figure imaging type, realizes various fundus
The acquisition of image.
The purpose of the present invention adopts the following technical scheme that realization: a kind of OCT system of the confocal fundus imaging of multiple light courcess, including
OCT light source, first light source, beam treatment unit, reference arm, reference mirror, sample arm, sample, long wave pass filter or short
Wave pass filter, the first signal processing module, second signal processing module and computer,
The OCT light source issues the first light beam, first light beam through the beam treatment unit become the second light beam and
5th light beam, second light beam reach the reference mirror by the reference arm；5th light beam is logical by the long wave
Optical filter or short wave pass filter piece form the 6th light beam, and the 6th light beam reaches sample by the sample arm, and
It is reflected in the different depth of sample；
The first light source is used to provide the described the lighting source of the first image, and the first light source is set to described tested
On the confocal point of sample；The first light source issues third light beam, and the third light beam is through the long wave pass filter or shortwave
Pass filter is the 4th light beam；4th light beam reaches sample by the sample arm, and in the difference of sample
Depth is reflected；
Second light beam reflects to form reference beam along former input path by reference mirror, and the 6th light beam passes through quilt
Sample reflects to form signal beams along former input path；The signal beams are filtered by the long wave pass filter or short-pass
Mating plate forms the first signal beams, the reference beam and first signal beams and couples shape by the beam treatment unit
At interfering beam；4th light beam reflects to form second signal light beam along former input path by sample；
The second signal light beam forms the first data flow through first signal processing module, and the interfering beam passes through
The second signal processing module forms the second data flow；
First data flow samples to form the first image by the computer, described in the second data flow process
Computer samples to form the second image.
Further, first signal processing module includes photodetector, and the photodetector is set to the quilt
On the confocal point of sample.
Further, the second signal processing module includes spectrometer.
Further, the OCT system further includes collimation lens, and the collimation lens is used for respectively by second light beam
Collimated light beam is converted to by a light beam with third light beam.
Further, the OCT system further includes the first galvanometer and the second galvanometer, and first galvanometer and the second galvanometer are used
The incident direction of sample is injected in controlling the 4th light beam, and then two-dimensional scanning is carried out to sample.
Further, the OCT system further includes galvanometer control unit, and the galvanometer control unit is for controlling described the
The rotation of one galvanometer and the second galvanometer, the galvanometer control unit includes vibrating mirror driver.
Further, the OCT light source is super-radiance light emitting diode, and the beam treatment unit is fiber coupler.
Further, the sample is human eye, and first image is fundus imaging figure, second image
For eyeground tomograph.
Compared with prior art, the beneficial effects of the present invention are:
By accessing the light source of different wave length in total focal point, focal point is total to sample by the first signaling module
The acquisition of signal may be implemented the acquisition of various fundus image, and then provide diagnostic message more abundant for clinician.
Invention is further described in detail with reference to the accompanying drawings and detailed description.
Detailed description of the invention
Fig. 1 is the system schematic of one embodiment of the invention；
Fig. 2 is the confocal position view of the present invention；
Fig. 3 is the system schematic of another embodiment of the present invention；
Fig. 4 is system light path figure of the invention.
In figure: 1, OCT light source；2, beam treatment unit；31, short wave pass filter；32, long wave pass filter；4, first
Signal processing module；41, photodetector；5, second signal processing module；8, computer；10, galvanometer unit；101, the first vibration
Mirror；102, the second galvanometer；11, collimation lens；12, reference mirror；13, sample；20, reference arm；30, sample arm；40, first
Light source；51, the first confocal point；52, the second confocal point；53, the confocal point of third；54, the 4th confocal point；55, the 5th confocal point；A,
First light beam；B, the second light beam；C, reference beam；D, third light beam；F, signal beams；G, interfering beam；H, the 4th light beam；N,
5th light beam；O, the 6th light beam；J, the first data flow；K, the second data flow；L, the first signal beams；M, second signal light beam.
Specific embodiment
In the following, being described further in conjunction with attached drawing and specific embodiment to the present invention, it should be noted that not
Under the premise of conflicting, new implementation can be formed between various embodiments described below or between each technical characteristic in any combination
Example.
As Figure 1 and Figure 4, the OCT system of the confocal fundus imaging of a kind of multiple light courcess, including OCT light source 1, beam treatment list
Member 2, reference arm 20, reference mirror 12, sample arm 30, sample 13, long wave pass filter 32 or short wave pass filter 31, first
Signal processing module 4, second signal processing module 5 and computer 8, OCT light source 1 and beam treatment unit 2 are connected using optical fiber,
OCT light source 1 issues the first light beam A, and the first light beam A is divided by beam treatment unit 2 for the second light beam B and the 5th light beam N, and second
Light beam B reaches reference mirror 12 by reference arm 20；5th light beam N is by long wave pass filter 32 or the formation of short wave pass filter 31
6th light beam O, the 6th light beam O reach sample 13 by sample arm 30, and carry out instead in the different depth of sample 13
It penetrates；
First light source 40 is set to the confocal of sample 13 for providing the lighting source of the first image, first light source 40
On point, first light source 40 issues third light beam D, and third light beam D divides by long wave pass filter 32 or short wave pass filter 31 is
4th light beam H, the 4th light beam H reach sample 13 by sample arm 30, and carry out instead in the different depth of sample 13
It penetrates；
Second light beam B reflects to form reference beam C along former input path by reference mirror 12, and the 6th light beam O is by tested
Sample 13 reflects to form signal beams F along former input path, and signal beams F passes through short wave pass filter 31 or long wave pass filter
32 formation the first signal beams L, reference beam C and the first signal beams L form interfering beam by the coupling of beam treatment unit 2
G；4th light beam H reflects to form second signal light beam M along former input path by sample 13；
Second signal light beam M forms the first data flow J through the first signal processing module 4, and interfering beam G passes through second signal
Processing module 5 forms the second data flow K；First data flow J forms the first image, the second data flow K by the sampling of computer 8
It is sampled by computer 8 and forms the second image.First signal processing module 4 includes photodetector 41, photodetector 41
It can be single-point photodetector.Second signal processing module 5 includes spectrometer.OCT system further includes collimation lens 11, collimation
Lens 11 are for being converted to collimated light beam by a light beam for the second light beam B and third light beam D respectively.OCT system further includes galvanometer
Unit 10, galvanometer unit 10 include the first galvanometer 101 and the second galvanometer 102, and the first galvanometer 101 and the second galvanometer 102 are for controlling
The incident direction that the 4th light beam H injects sample 13 is made, and then two-dimensional scanning is carried out to sample 13.OCT system is also wrapped
Galvanometer control unit is included, galvanometer control unit is used to control the rotation of the first galvanometer 101 and the second galvanometer 102, and galvanometer control is single
Member includes vibrating mirror driver.OCT light source 1 is super-radiance light emitting diode, and beam treatment unit 2 is fiber coupler.OCT light source
1 is super-radiance light emitting diode, and beam treatment unit 2 is fiber coupler.Optical fiber is used between fiber coupler and spectrometer
Connection, OCT light source 1 are super-radiance light emitting diode, the fiber coupler that beam treatment unit 2 is 2 × 2.
First light source 40 provides the lighting source of first image, and first light source 40 is set to the confocal of sample 13
On point, while photodetector 41 is also set on the confocal point of sample 13.The confocal point of sample 13 is in OCT system
Position as shown in Fig. 2, altogether there are five confocal point, the respectively first confocal point 52 of confocal point 51, second, the confocal point 53 of third,
4th confocal point 54, the 5th confocal point 55.Wherein, the position of photodetector 41 and first light source 40 can be located at five it is confocal
On the same confocal point in point, it can also be respectively provided on the confocal point of difference in five confocal points.First image can be
Fundus fluorescein angiography figure, the wavelength of first light source 40 is 465nm to 490nm at this time；First image can be indoles
Dark green angiogram, the wavelength of first light source 40 is 795nm at this time；First image can also be the multispectral figure in eyeground, this
When first light source 40 wavelength be 760nm, 780nm, 820nm, 880nm.It, can when first light source 40 is using different wave length
To obtain the first different images, above-mentioned the first different image can provide diagnosis letter more abundant for clinician
Breath.
Wherein, the selection gist of short wave pass filter 31 or long wave pass filter 32 is: comparing OCT light source 1 and the first light
The size of both sources 40 wavelength, when the wavelength of first light source 40 is greater than the wavelength of OCT light source 1, selection is grown in the optical path
Wave pass filter；When the wavelength of first light source 40 is less than the wavelength of OCT light source 1, short-pass is selected to filter in the optical path
Piece.
Since transverse cross-sectional view and longitudinal sectional drawing are obtained by 13 confocal imaging of sample, the program can be solved
Certainly transverse cross-sectional view and longitudinal sectional drawing are to separate imaging so as to cause the problem of imaging results inaccuracy.
This system can be applied to the imaging of the multiple fields such as ophthalmology, skin, gastrointestinal tract.In the present embodiment, sample
13 be human eye, and the first image is eyeground tomograph, and the second image is fundus imaging figure.
The OCT light source 1 of this system can also use swept light source, when using swept light source, second signal processing
Spectrometer in module 5 is replaced into photodetector.
System work when, the first image and the second image can be acquired simultaneously, once can also only acquire first at
As figure or the second image, in the case where only needing a figure that can judge to sample 13, only acquisition first
Image or the second image, speed are faster, more efficient.
It can be by being detected the stability of layout to judge OCT system to the signal that photodetector obtains, to biography
The OCT system of system provides a kind of detection means of new stabilization of equipment performance.
As shown in figure 3, other parts are same as the previously described embodiments in the 3rd embodiment of OCT system of the invention,
Long wave pass filter 32 or short wave pass filter 31 are mountable before galvanometer unit 10, the first image, that is, eyeground tomograph,
It is to handle to obtain by the reflected light signal of the same position of sample 13 with the second image, that is, fundus imaging figure,
Goal of the invention of the invention may be implemented.
The above embodiment is only the preferred embodiment of the present invention, and the scope of protection of the present invention is not limited thereto,
The variation and replacement for any unsubstantiality that those skilled in the art is done on the basis of the present invention belong to institute of the present invention
Claimed range.
Claims (10)
1. a kind of OCT system of the confocal fundus imaging of multiple light courcess, including OCT light source, first light source, beam treatment unit, reference
Arm, reference mirror, sample arm, sample, long wave pass filter or short wave pass filter, the first signal processing module, the second letter
Number processing module and computer, which is characterized in that
The OCT light source issues the first light beam, and first light beam becomes the second light beam and the 5th through the beam treatment unit
Light beam, second light beam reach the reference mirror by the reference arm；5th light beam filters by the long wave is logical
Piece or short wave pass filter piece form the 6th light beam, and the 6th light beam reaches sample by the sample arm, and in quilt
The different depth of sample is reflected；
The first light source is used to provide the described the lighting source of the first image, and the first light source is set to the sample
Confocal point on；The first light source issues third light beam, and the third light beam is filtered through the long wave pass filter or short-pass
Mating plate is the 4th light beam；4th light beam reaches sample by the sample arm, and in the different depth of sample
It is reflected；
Second light beam reflects to form reference beam along former input path by reference mirror, and the 6th light beam passes through detected sample
Product reflect to form signal beams along former input path；The signal beams pass through the long wave pass filter or short wave pass filter
Form the first signal beams, the reference beam and first signal beams coupled by the beam treatment unit to be formed it is dry
Relate to light beam；4th light beam reflects to form second signal light beam along former input path by sample；
The second signal light beam forms the first data flow through first signal processing module, described in the interfering beam passes through
Second signal processing module forms the second data flow；
First data flow samples to form the first image by the computer, and second data flow passes through the calculating
Machine samples to form the second image.
2. the OCT system of the confocal fundus imaging of multiple light courcess as described in claim 1, which is characterized in that at first signal
Managing module includes photodetector, and the photodetector is set on the confocal point of the sample.
3. the OCT system of the confocal fundus imaging of multiple light courcess as claimed in claim 2, which is characterized in that at the second signal
Managing module includes spectrometer.
4. the OCT system of the confocal fundus imaging of multiple light courcess as described in claims 1 or 2 or 3, which is characterized in that the OCT system
System further includes collimation lens, and the collimation lens is used to respectively be converted to second light beam and third light beam by a light beam flat
Row light beam.
5. the OCT system of the confocal fundus imaging of multiple light courcess as claimed in claim 4, which is characterized in that the OCT system is also wrapped
The first galvanometer and the second galvanometer are included, first galvanometer and the second galvanometer are used to control the 4th light beam and inject sample
Incident direction, and then two-dimensional scanning is carried out to sample.
6. the OCT system of the confocal fundus imaging of multiple light courcess as claimed in claim 5, which is characterized in that the OCT system is also wrapped
Galvanometer control unit is included, the galvanometer control unit is used to control the rotation of first galvanometer and the second galvanometer, the galvanometer
Control unit includes vibrating mirror driver.
7. the OCT system of the confocal fundus imaging of multiple light courcess as described in claims 1 or 2 or 3, which is characterized in that the OCT light
Source is super-radiance light emitting diode, and the beam treatment unit is fiber coupler.
8. the OCT system of the confocal fundus imaging of multiple light courcess as claimed in claim 4, which is characterized in that the OCT light source is super
Radiation light emitting diode, the beam treatment unit are fiber coupler.
9. the OCT system of the confocal fundus imaging of multiple light courcess as claimed in claim 5, which is characterized in that the OCT light source is super
Radiation light emitting diode, the beam treatment unit are fiber coupler.
10. the OCT system of the confocal fundus imaging of multiple light courcess as described in claims 1 or 2 or 3, which is characterized in that described tested
Sample is human eye, and first image is fundus imaging figure, and second image is eyeground tomograph.
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