CN108937842A - A kind of OCT system integrating confocal fundus imaging - Google Patents
A kind of OCT system integrating confocal fundus imaging Download PDFInfo
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- CN108937842A CN108937842A CN201810745917.2A CN201810745917A CN108937842A CN 108937842 A CN108937842 A CN 108937842A CN 201810745917 A CN201810745917 A CN 201810745917A CN 108937842 A CN108937842 A CN 108937842A
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- 238000003384 imaging method Methods 0.000 title claims abstract description 35
- 239000000835 fiber Substances 0.000 claims description 11
- 230000002452 interceptive effect Effects 0.000 claims description 5
- 230000003287 optical effect Effects 0.000 abstract description 13
- 238000000034 method Methods 0.000 abstract description 6
- 238000002059 diagnostic imaging Methods 0.000 abstract description 2
- 238000012014 optical coherence tomography Methods 0.000 description 38
- 230000008520 organization Effects 0.000 description 8
- 239000013307 optical fiber Substances 0.000 description 6
- 238000005259 measurement Methods 0.000 description 4
- 238000001514 detection method Methods 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 238000010226 confocal imaging Methods 0.000 description 1
- 230000008878 coupling Effects 0.000 description 1
- 238000010168 coupling process Methods 0.000 description 1
- 238000005859 coupling reaction Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 210000001035 gastrointestinal tract Anatomy 0.000 description 1
- 238000009434 installation Methods 0.000 description 1
- 230000005622 photoelectricity Effects 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/12—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions for looking at the eye fundus, e.g. ophthalmoscopes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B3/00—Apparatus for testing the eyes; Instruments for examining the eyes
- A61B3/10—Objective types, i.e. instruments for examining the eyes independent of the patients' perceptions or reactions
- A61B3/14—Arrangements specially adapted for eye photography
Abstract
The present invention relates to medical imaging techniques fields, disclose a kind of OCT system for integrating confocal fundus imaging, including OCT light source, beam treatment unit, reference arm, reference mirror, sample arm, sample, light splitting piece and computer, OCT light source issues the first light beam, the first light beam of beam treatment unit point is the second light beam and third light beam, second light beam reaches reference mirror by reference arm, and third light beam is the 4th light beam by light splitting piece, and the 4th light beam reaches sample by sample arm；In traditional OCT system, by increasing light splitting piece in systems, optical signal is divided into two, a part of optical signal obtains the first image by processing, another part optical signal obtains the second image by processing, since the first image of sample and the second image are the first images of the sample for handling to obtain, therefore obtaining by the reflected light signal of the same position of sample and the second image is to correspond completely in position, position correction is done to this two figures without the later period.
Description
Technical field
The present invention relates to medical imaging techniques fields, more particularly to a kind of OCT system for integrating confocal fundus imaging.
Background technique
OCT (Optical Coherence Tomography, means of optical coherence tomography) imaging is from ultrasound
Wave imaging technique, the characteristics of combining low coherence interference and confocal micro-measurement, by the phase delay of detection scattering light wave, from
Scattering light at organic organization's different depth with refer to the interference of light, to detect reflection depth corresponding to phase delay, then
Scanned by light beam, signal conversion, data extract and etc. obtain the tomograph of organic organization, that is, the longitudinal direction of organic organization
Sectional view, thus the case where judging tested organic organization according to tomograph.Usually obtain organic organization tomograph it
Before, it is also necessary to the transverse cross-sectional view for obtaining tested organic organization, judged by transverse cross-sectional view tested organic organization need into
The position of row tomographic imaging.
Currently, the transverse cross-sectional view and longitudinal sectional drawing of traditional tested organic organization are to separate measurement, due to measurement
Instrument, the influence of the factors such as measurement environment, transverse cross-sectional view and longitudinal sectional drawing needs are adjusted after imaging, are just able to achieve cross
To the reciprocal correspondence of sectional view and longitudinal sectional drawing.
Summary of the invention
For overcome the deficiencies in the prior art, the purpose of the present invention is to provide a kind of OCT for integrating confocal fundus imaging
System solves in traditional OCT image, and transverse cross-sectional view and longitudinal sectional drawing are to separate imaging to be not allowed so as to cause imaging results
True problem.
The purpose of the present invention adopts the following technical scheme that realization: a kind of OCT system integrating confocal fundus imaging, including
OCT light source, beam treatment unit, reference arm, reference mirror, sample arm, sample, light splitting piece, the first signal processing module,
Binary signal processing module and computer,
The OCT light source issues the first light beam, and the beam treatment unit point first light beam is the second light beam and the
Three light beams, second light beam reach the reference mirror by the reference arm, and the third light beam is by the light splitting piece
4th light beam, the 4th light beam reach sample by the sample arm；
Second light beam reflects to form reference beam along former input path by reference mirror, and the 4th light beam passes through quilt
Sample reflects to form signal beams along former input path, and the signal beams form the first signal beams by the light splitting piece
With second signal light beam, the reference beam and first signal beams couple to form interference by the beam treatment unit
Light beam；
The second signal light beam forms the first data flow through first signal processing module, and the interfering beam passes through
The second signal processing module forms the second data flow；
First data flow samples to form the first image by the computer, described in the second data flow process
Computer samples to form the second image.
Further, first signal processing module includes photodetector and aperture plate.
Further, the second signal processing module includes spectrometer.
Further, the OCT system further includes collimation lens, and the collimation lens is used for respectively by second light beam
Collimated light beam is converted to by a light beam with third light beam.
Further, the OCT system further includes the first galvanometer and the second galvanometer, and first galvanometer and the second galvanometer are used
The incident direction of sample is injected in controlling the 4th light beam, and then two-dimensional scanning is carried out to sample.
Further, the OCT system further includes galvanometer control unit, and the galvanometer control unit is for controlling described the
The rotation of one galvanometer and the second galvanometer, the galvanometer control unit includes vibrating mirror driver.
Further, the OCT light source is super-radiance light emitting diode, and the beam treatment unit is fiber coupler.
Further, the OCT light source is super-radiance light emitting diode, and the beam treatment unit is fiber coupler.
Further, the OCT light source is super-radiance light emitting diode, and the beam treatment unit is fiber coupler.
Further, the sample is human eye, and first image is fundus imaging figure, second image
For eyeground tomograph.
Compared with prior art, the beneficial effects of the present invention are:
1., by increasing light splitting piece in systems, optical signal is divided into two in traditional OCT system, a part of light letter
Number the first image is obtained by processing, another part optical signal obtains the second image by processing, due to the first of sample
Image and the second image are the samples for handling to obtain, therefore obtaining by the reflected light signal of the same position of sample
The first image and the second image be to correspond completely in position, position correction is done to this two figures without the later period；
Also, since the acquisition of two figures is using same optical path, compared to the existing method for obtaining the first image, the present invention is provided
OCT system obtain the first image caused by extra charge it is low, more economically.
Invention is further described in detail with reference to the accompanying drawings and detailed description.
Detailed description of the invention
Fig. 1 is the system schematic of first embodiment of the invention；
Fig. 2 is the system schematic of second embodiment of the invention；
Fig. 3 is the system schematic of third embodiment of the invention；
Fig. 4 is system light path figure of the invention.
In figure: 1, OCT light source；2, beam treatment unit；3, light splitting piece；4, the first signal processing module；41, photodetection
Device；42, aperture plate；5, second signal processing module；8, computer；10, galvanometer unit；101, the first galvanometer；102, the second vibration
Mirror；11, collimation lens；12, reference mirror；13, sample；20, reference arm；30, sample arm；A, the first light beam；B, the second light
Beam；C, reference beam；D, third light beam；F, signal beams；G, interfering beam；H, the 4th light beam；J, the first data flow；K, second
Data flow；L, the first signal beams；M, second signal light beam.
Specific embodiment
In the following, being described further in conjunction with attached drawing and specific embodiment to the present invention, it should be noted that not
Under the premise of conflicting, new implementation can be formed between various embodiments described below or between each technical characteristic in any combination
Example.
As shown in Figure 2, Figure 4 shows, a kind of OCT system integrating confocal fundus imaging, including OCT light source 1, beam treatment unit
2, reference arm 20, reference mirror 12, sample arm 30, sample 13, light splitting piece 3, the first signal processing module 4, at second signal
Module 5 and computer 8 are managed, OCT light source 1 is connected with beam treatment unit 2 using optical fiber, and OCT light source 1 issues the first light beam A, light
Beam processing unit 2 divides the first light beam A to reach reference mirror by reference arm 20 for the second light beam B and third light beam D, the second light beam B
12, third light beam D divide by light splitting piece 3 for the 4th light beam H and the 5th light beam, and the 5th signal beams are not acquired it.
4th light beam H reaches sample 13 by sample arm 30；Second light beam B is by reference mirror 12 along former input path
Reference beam C is reflected to form, the 4th light beam H reflects to form signal beams F, signal light along former input path by sample 13
Beam F forms the first signal beams L and second signal light beam M, reference beam C by light splitting piece 3 and the first signal beams L passes through light
The coupling of beam processing unit 2 forms interfering beam G；Second signal light beam M forms the first data flow J through the first signal processing module 4,
Interfering beam G forms the second data flow K by second signal processing module 5；First data flow J is formed by the sampling of computer 8
First image, the second data flow K form the second image by the sampling of computer 8.First signal processing module 4 includes photoelectricity
Detector 41 and aperture plate 42, photodetector 41 can be single-point photodetector.Second signal processing module 5 includes spectrum
Instrument.OCT system further includes collimation lens 11, and collimation lens 11 is for respectively being turned the second light beam B and third light beam D by light beam
It is changed to collimated light beam.OCT system further includes galvanometer unit 10, and galvanometer unit 10 includes the first galvanometer 101 and the second galvanometer 102,
First galvanometer 101 and the second galvanometer 102 are used to control the incident direction that the 4th light beam H injects sample 13, and then to tested
Sample 13 carries out two-dimensional scanning.OCT system further includes galvanometer control unit, and galvanometer control unit is for controlling the first galvanometer 101
With the rotation of the second galvanometer 102, galvanometer control unit includes vibrating mirror driver.OCT light source 1 is super-radiance light emitting diode, light
Beam processing unit 2 is fiber coupler.OCT light source 1 is super-radiance light emitting diode, and beam treatment unit 2 is fiber coupler.
It is connected between fiber coupler and spectrometer using optical fiber, OCT light source 1 is super-radiance light emitting diode, and beam treatment unit 2 is
2 × 2 fiber coupler.
This system can be applied to the imaging of the multiple fields such as ophthalmology, skin, gastrointestinal tract.In the present embodiment, sample
13 be human eye, and the first image is eyeground tomograph, and the second image is fundus imaging figure.
The OCT light source 1 of this system can also use swept light source, when using swept light source, second signal processing
Spectrometer in module 5 is replaced into photodetector.
System work when, the first image and the second image can be acquired simultaneously, once can also only acquire first at
As figure or the second image, in the case where only needing a figure that can judge to sample 13, only acquisition first
Image or the second image, speed are faster, more efficient.
OCT system in the present invention, using existing light path devices, only needs on the basis of traditional OCT fundus imaging
Increase aperture plate 42 and a high s/n ratio and high-resolution eyeground confocal imaging can be realized in single-point photodetector 41,
Namely first image, therefore cost is relatively low for whole system.
The imaging optical path of OCT system in the present invention, the imaging optical path of the first image namely confocal fundus imaging by
Then aperture plate 42 is used, imaging optical path is to use space optical path rather than optic fibre light path, imaging capability can be effectively improved,
The requirement to photodetector is reduced, cheap photodetector can be used, reduce the cost of whole system.Meanwhile by
In imaging optical path, it is provided with aperture plate 42, the influence of stray light and ghost to image quality is effectively reduced, is not reducing
On the basis of the image quality of second image, the image quality of the first image is effectively raised.
OCT system in the present invention obtains two-way beam signal using light splitting piece 3, and beam signal is all the same, therefore obtains
The first image and the second image image quality it is higher.
It can be by being detected the stability of layout to judge OCT system to the signal that photodetector obtains, to biography
The OCT system of system provides a kind of detection means of new stabilization of equipment performance
As shown in Figure 1, other parts are same as the previously described embodiments in the second embodiment of OCT system of the invention,
Aperture plate 42 can be replaced by optical fiber, carry out optical path connection, connected detector using optical fiber, formed by the end face and eyeground of optical fiber
It is confocal, it can simplify the debugging process of optical path, additionally by optical fiber light-guiding, the installation that can be convenient detector is put.
As shown in figure 3, other parts are same as the previously described embodiments in the 3rd embodiment of OCT system of the invention,
Light splitting piece 3 is mountable before galvanometer unit 10, the first image, that is, eyeground tomograph and the second image, that is, fundus imaging figure
It is to handle to obtain by the reflected light signal of the same position of sample 13, invention mesh of the invention also may be implemented
's.
The above embodiment is only the preferred embodiment of the present invention, and the scope of protection of the present invention is not limited thereto,
The variation and replacement for any unsubstantiality that those skilled in the art is done on the basis of the present invention belong to institute of the present invention
Claimed range.
Claims (10)
1. a kind of OCT system for integrating confocal fundus imaging, including OCT light source, beam treatment unit, reference arm, reference mirror, sample
Product arm, sample, light splitting piece, the first signal processing module, second signal processing module and computer, which is characterized in that
The OCT light source issues the first light beam, and the beam treatment unit point first light beam is the second light beam and third light
Beam, second light beam reach the reference mirror by the reference arm, and the third light beam is the 4th by the light splitting piece
Light beam, the 4th light beam reach sample by the sample arm；
Second light beam reflects to form reference beam along former input path by reference mirror, and the 4th light beam passes through detected sample
Product reflect to form signal beams along former input path, and the signal beams form the first signal beams and the by the light splitting piece
Binary signal light beam, the reference beam and first signal beams couple to form interference light by the beam treatment unit
Beam；
The second signal light beam forms the first data flow through first signal processing module, described in the interfering beam passes through
Second signal processing module forms the second data flow；
First data flow samples to form the first image by the computer, and second data flow passes through the calculating
Machine samples to form the second image.
2. integrating the OCT system of confocal fundus imaging as described in claim 1, which is characterized in that first signal processing
Module includes photodetector and aperture plate.
3. integrating the OCT system of confocal fundus imaging as claimed in claim 2, which is characterized in that the second signal processing
Module includes spectrometer.
4. the OCT system for integrating confocal fundus imaging as described in claims 1 or 2 or 3, which is characterized in that the OCT system
It further include collimation lens, the collimation lens is used to respectively be converted to second light beam by a light beam with third light beam parallel
Light beam.
5. integrating the OCT system of confocal fundus imaging as claimed in claim 4, which is characterized in that the OCT system further includes
First galvanometer and the second galvanometer, first galvanometer and the second galvanometer are used to control the 4th light beam and inject entering for sample
Direction is penetrated, and then two-dimensional scanning is carried out to sample.
6. integrating the OCT system of confocal fundus imaging as claimed in claim 5, which is characterized in that the OCT system further includes
Galvanometer control unit, the galvanometer control unit are used to control the rotation of first galvanometer and the second galvanometer, the galvanometer control
Unit processed includes vibrating mirror driver.
7. the OCT system for integrating confocal fundus imaging as described in claims 1 or 2 or 3, which is characterized in that the OCT light source
For super-radiance light emitting diode, the beam treatment unit is fiber coupler.
8. integrating the OCT system of confocal fundus imaging as claimed in claim 4, which is characterized in that the OCT light source is super spoke
Light emitting diode is penetrated, the beam treatment unit is fiber coupler.
9. integrating the OCT system of confocal fundus imaging as claimed in claim 5, which is characterized in that the OCT light source is super spoke
Light emitting diode is penetrated, the beam treatment unit is fiber coupler.
10. the OCT system for integrating confocal fundus imaging as described in claims 1 or 2 or 3, which is characterized in that the detected sample
Product are human eye, and first image is fundus imaging figure, and second image is eyeground tomograph.
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