CN203280368U - Parallel OCT detection system based on spectral coding and orthogonal light splitting - Google Patents
Parallel OCT detection system based on spectral coding and orthogonal light splitting Download PDFInfo
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- CN203280368U CN203280368U CN2013202759741U CN201320275974U CN203280368U CN 203280368 U CN203280368 U CN 203280368U CN 2013202759741 U CN2013202759741 U CN 2013202759741U CN 201320275974 U CN201320275974 U CN 201320275974U CN 203280368 U CN203280368 U CN 203280368U
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Abstract
The utility model discloses a parallel OCT detection system based on spectral coding and orthogonal light splitting. According to the parallel OCT detection system, a series of optical frequency combs with the frequency mutually not overlapped can be formed in different transverse detection positions of a sample, and further spectral coding and parallel lighting of the transverse positions of the sample are achieved. A two-level space orthogonal light splitting spectrograph is used for forming a detection arm of the parallel OCT detection system, the detection arm is composed of a virtual image phased array and an optical grating, and the detection arm uses a high-speed area array CCD as a detector to carry out parallel detection of an interference spectral signal. Spectral information is transmitted to a computer ultimately, and rapid reconstitution of transverse location information and axial depth information of the sample is achieved on the computer. By means of the parallel OCT detection system based on spectral coding and orthogonal light splitting, under the premise that the requirement for high spectral resolution is met, an all-fiber system can replace a space optical system, the problem of coherent crosstalk existing in original parallel detection can be solved, and therefore parallel spectral domain OCT imaging with high SNR, high transverse resolution and high axial resolution can be achieved.
Description
Technical field
This utility model belongs to optical field, relates to a kind of based on the optical spectrum encoded and parallel OCT detection system quadrature light splitting.
Background technology
Optical coherent chromatographic imaging (Optical Coherence Tomography, OCT) can be implemented noncontact, not damaged, the high-resolution imaging in vivo of live body internal organizational structure and physiological function, in the biomedical imaging field, has a wide range of applications.
Present spectral coverage OCT system gathers the spectral components of interference signal by high speed linear array CCD (or linear array CMOS), need not axial scan and just can obtain the depth information of sample, have quick and highly sensitive characteristics, but due to the needs transversal scanning, thereby image taking speed still is restricted, be not suitable for measuring need to extremely short imaging time the motion sample.Therefore, spectral coverage OCT is necessary to adopt the method for parallel detecting, in the situation that need not axial scan and the two dimensional image imaging is carried out in transversal scanning.
External a lot of scientific research institution has all carried out the research of this respect, S. Witte group as Amsterdam, the Netherlands Free University has built the centre wavelength based on 808nm, the parallel spectral coverage OCT system of the femto-second laser of bandwidth 60nm, the two dimensional image imaging time of 1392 * 1040 pixels is 0.2ms, and axial resolution is 5um; The Yoshiaki Yasuno group of Japan University of tsukuba, built the centre wavelength based on 840nm, and the parallel spectral coverage OCT system of the femto-second laser of bandwidth 50nm, simultaneously in conjunction with transversal scanning, has realized amphiblestroid three-dimensional imaging, and axial resolution is 7.4um.Above-described parallel spectral coverage OCT system is to use cylindrical lens to obtain the line illumination in sample arm to survey light.Owing to using coherent source, have higher coherence in the line illumination light between the luminous point of diverse location, thereby scattered light will be introduced coherent crosstalk, cause surveying signal to noise ratio and descend, the system lateral resolution descends then, has finally reduced image quality.In addition, traditional parallel spectral coverage OCT system, on sample, the detection light of diverse location is only separated on direction in space, therefore can't use fibre system, and can only use the free space system, and this has increased volume and the complexity of system greatly.
The coherent crosstalk that brings for eliminating coherent source, the Branislav Grajciar group of Austria Vienna medical college uses thermal light source to test, result shows that the luminous power of light source is not enough to carry out the imaging of biological tissue, and the imaging depth of wide spectrum light source is very limited.
The Tatsutoshi Shioda group of Japan Changgong university has used the light splitting of virtual image phased array in reference arm, avoided coherent crosstalk, but owing to surveying light, does not carry out light splitting, has caused the decline of coherent contrast degree, and can't use fibre system equally.
The D.Yelin group of Harvard Medical School proposes optical spectrum encoded endoscope, realizes the parallel imaging technique of simple optical fiber, but owing to surveying light spectral bandwidth after grating beam splitting, narrows down, and has caused the decline of axial resolution.
Therefore, how in the situation that guarantee that it is the large technological difficulties of spectral coverage OCT system development that walk abreast that imaging resolution is completed axial and horizontal complete parallel measurement.
Summary of the invention
In order to overcome above-mentioned the deficiencies in the prior art, it is a kind of based on the optical spectrum encoded and parallel OCT detection system quadrature light splitting that this utility model provides.
The purpose of this utility model is achieved by the following technical solution:
, based on the optical spectrum encoded and parallel OCT detection system quadrature light splitting, comprise wideband light source, optical circulator, broadband optical fiber coupler, the first fiber collimating lenses, the second fiber collimating lenses, the 3rd fiber collimating lenses, the first cylindrical focusing lens, the second cylindrical focusing lens, the first condenser lens, the second condenser lens, the first virtual image phased array, the second virtual image phased array, grating, sample, plane mirror, high speed face array CCD or high-speed area array CMOS.
From wideband light source low-coherent light out, incide broadband optical fiber coupler through optical circulator, a road light enters sample arm after light splitting; Described sample arm: the light after the broadband optical fiber coupler light splitting incides the cylinder of the first cylindrical focusing lens through the first fiber collimating lenses, plane outgoing from the first cylindrical focusing lens, the light of outgoing converges to the entrance window of the first virtual image phased array front surface, rear surface outgoing from the first virtual image phased array, shine sample after the first condenser lens, the light that reflects from sample is back to broadband optical fiber coupler via former road.
Another road light after the broadband optical fiber coupler light splitting enters reference arm.Described reference arm: the light after the broadband optical fiber coupler light splitting shines plane mirror through the second fiber collimating lenses, and the light that reflects from plane mirror is back to broadband optical fiber coupler via former road.
Form interference light the two-way light that returns from sample arm and reference arm is interfered broadband optical fiber coupler after, through optical circulator, enter feeler arm, by feeler arm, interference light is decomposed into the interference spectrum signal.Described feeler arm: interference light is through the 3rd fiber collimating lenses, incide the cylinder of the second cylindrical focusing lens, plane outgoing from the second cylindrical focusing lens, the light of outgoing converges to the entrance window of the second virtual image phased array front surface, rear surface outgoing from the second virtual image phased array, carry out the first order light splitting on spatial domain, reenter and be mapped to grating, carry out second level light splitting on the orthogonal intersection space direction,, through the second condenser lens imaging, adopt high speed face array CCD or high-speed area array CMOS to carry out parallel detecting.Last these spectral signals change the signal of telecommunication into and import computer into, and implement Fourier transform scheduling algorithm processing reconstructed sample image in computer.
Compare with background technology, the beneficial effect that the utlity model has is:
1. by using virtual image phased array to implement the dispersion light splitting to detecting light beam on sample arm, realization is optical spectrum encoded to the sample lateral attitude, again by using identical virtual image phased array to carry out corresponding spectrum decoding, the horizontal information of going back raw sample on feeler arm.Compare traditional parallel OCT system, on sample, the reflected light of different lateral attitudes is not overlapping mutually on spectrum, thereby between the reflected light of diverse location, the coherence is poor, can eliminate comparatively up hill and dale the phenomenon of coherent crosstalk, thereby significantly improves the lateral resolution that parallel OCT surveys.On sample arm, traditional optical spectrum encoded spectral resolution that generally adopts is low, and the wide grating of Free Spectral Range carries out light splitting, and the spectral bandwidth that causes the line illumination to survey each luminous point of light narrows down, thereby causes the decline of axial resolution.This utility model uses on sample arm virtual image phased array, has spectral resolution high, the characteristics that Free Spectral Range is narrow, thereby the spectrum of each luminous point of line illumination detection light is optical frequency com, and the overall bandwidth of these optical frequency coms is all close to the bandwidth of light source, thereby can avoid the decline of axially differentiating.2. because the lateral attitude information to sample in sample arm has been carried out optical spectrum encoded, the different lateral attitudes of the optical frequency com irradiation sample surfaces of different frequency, in the optical signal that reflects, the optical frequency com of different frequency carries the sample interior structural information of different lateral attitudes, thereby can replace the free space system with fibre system, whole spectrum investigating system is more easily realized miniaturization and integrated.
Description of drawings
Fig. 1 is system structure principle schematic of the present utility model;
Fig. 2 is 3-D view and the optical spectrum encoded principle schematic thereof of this utility model sample arm;
Fig. 3 is the 3-D view of this utility model feeler arm;
Fig. 4 is the virtual image phased array light splitting schematic diagram of this utility model feeler arm;
Fig. 5 is the grating beam splitting schematic diagram of this utility model feeler arm;
Fig. 6 is the principle schematic of the decoding of this utility model spectrum and parallel detecting.
In figure: 1, wideband light source, 2, optical circulator, 3, broadband optical fiber coupler, 4, collimating lens, 5, cylindrical lens, 6, virtual image phased array, 7, condenser lens, 8, sample, 9, collimating lens, 10, plane mirror, 11, collimating lens, 12, cylindrical lens, 13, virtual image phased array, 14, grating, 15, condenser lens, 16, high speed face array CCD or high-speed area array CMOS, 17, sample arm, 18, reference arm, 19, feeler arm.
The specific embodiment
Below in conjunction with accompanying drawing and exemplifying embodiment, this utility model is further described:
As shown in Figure 1, a kind of based on the optical spectrum encoded and parallel OCT detection system quadrature light splitting, comprise wideband light source 1, optical circulator 2, broadband optical fiber coupler 3, the first fiber collimating lenses 4, the second fiber collimating lenses 9, the 3rd fiber collimating lenses 11, the first cylindrical focusing lens 5, the second cylindrical focusing lens 12, the first condenser lens 7, the second condenser lens 15, the first virtual image phased array 6, the second virtual image phased array 13, grating 14, sample 8, plane mirror 10, high speed face array CCD or high-speed area array CMOS16.
From wideband light source 1 low-coherent light out, incide broadband optical fiber coupler 3 through optical circulator 2, a road enters sample arm 17 after light splitting; Described sample arm 17: the light after the broadband optical fiber coupler light splitting incides the cylinder of the first cylindrical focusing lens 5 through the first fiber collimating lenses 4, plane outgoing from the first cylindrical focusing lens 5, the light of outgoing converges to the entrance window of the first virtual image phased array 6 front surfaces, rear surface outgoing from the first virtual image phased array 6, shine sample 8 after the first condenser lens 7, the light that reflects from sample 8 is back to broadband optical fiber coupler 3 via former road.
Another road after broadband optical fiber coupler 3 light splitting enters reference arm 18.Described reference arm 18: the light after the broadband optical fiber coupler light splitting shines plane mirror 10 through the second fiber collimating lenses 9, and the light that reflects from plane mirror 10 is back to broadband optical fiber coupler 3 via former road.
Form interference light the two-way light that returns from sample arm 17 and reference arm 18 is interfered broadband optical fiber coupler 3 after, enter feeler arm 19, by feeler arm 19, interference light is decomposed into the interference spectrum signal.Described feeler arm 19: interference light is through the 3rd fiber collimating lenses 11, incide the cylinder of the second cylindrical focusing lens 12, plane outgoing from the second cylindrical focusing lens 12, the light of outgoing converges to the entrance window of the second virtual image phased array 13 front surfaces, rear surface outgoing from the second virtual image phased array 13, carry out the first order light splitting on spatial domain, reenter and be mapped to grating 14, carry out second level light splitting on the orthogonal intersection space direction,, through the second condenser lens 15 imagings, adopt high speed face array CCD or high-speed area array CMOS16 to carry out parallel detecting.Last these spectral signals change the signal of telecommunication into and import computer into, and implement the image of Fourier transform scheduling algorithm processing reconstructed sample 8 in computer.
As shown in Figure 2, the detection light that enters sample arm 17 via the first collimating lens 4 and the first cylindrical focusing lens 5 after, converge on the rear surface of the first virtual image phased array 6 and form straight line.Except incidence window, it is 100% total reflection film that the front surface of the first virtual image phased array 6 is coated with reflectance, thereby via the light beam that rear surface reflects, will all be reflected back rear surface, rear surface is coated with highly reflecting films, the Multi reflection of front and rear surfaces has formed a series of directional lights that focused on by the first cylindrical lens 5 and has converged the virtual image of the straight line that forms, i.e. virtual image array.Interfere with each other the effect that has produced the space light splitting between these virtual images, the light splitting light beam shines sample 8 after the first condenser lens 7 focuses on, and forms the line illumination and survey light on sample 8.The spectrum of each exploring spot on sample 8 is an optical frequency com, and these optical frequency coms are not overlapping mutually, thereby in the optical signal that reflects, the information of different probe units is recorded in the optical frequency com of different frequency, thereby the horizontal space information of sample 8, with form record and the transmission of spectrum, has realized optical spectrum encoded.For example, the corresponding spectrum of the exploring spot A on sample 8 be A1, A2, A3, A4 ..., the corresponding spectrum of exploring spot B be B1, B2, B3, B4 ...The spectrum of each exploring spot keeps the original bandwidth of wideband light source, so system can realize high axial resolution; Reflected light from different lateral attitudes on sample 8 is not overlapping mutually on spectrum, and the coherence is poor, can eliminate comparatively up hill and dale the phenomenon of coherent crosstalk, thereby significantly improves the lateral resolution that parallel OCT surveys.
As shown in Figure 3, in feeler arm 19, interference light is through the 3rd collimating lens 11 and the second cylindrical focusing lens 12, incide the second virtual image phased array 13, carry out first order light splitting on the y direction, reenter and be mapped to grating 14, carry out second level light splitting on the x direction, x direction and y direction are the orthogonal direction on space.Spectrum after the light splitting of front and back stages light-splitting device,, through the second condenser lens 15 imagings, adopt high speed face array CCD or high-speed area array CMOS16 to carry out parallel detecting.
As shown in Figure 4,5, the spectrum after the second virtual image phased array 13 light splitting distributes in the y-direction on high speed face array CCD or high-speed area array CMOS16, realizes the spectrum decoding; Spectrum after grating 14 light splitting distributes in the x-direction on high speed face array CCD or high-speed area array CMOS16, recorded the interference spectrum information of sample 8.Below in conjunction with Fig. 6, the principle of spectrum decoding and parallel detecting is described further.
As shown in Figure 6, high speed face array CCD or high-speed area array CMOS16 detect the quadrature spectrophotometric spectra.The spectral resolution of the second virtual image phased array 13 is high, Free Spectral Range is narrow, and what therefore distribute in the y-direction on high speed face array CCD 16 is continuous spectrum; The spectral resolution of grating 14 is less than the Free Spectral Range of the second virtual image phased array 13, and what therefore distribute in the x-direction is pectination spectrum, and two adjacent row continuous spectrums are end to end.Because the second virtual image phased array 13 has corresponding spectral resolution and Free Spectral Range with the first virtual image phased array 6, therefore be corresponding through the spectrum after the second virtual image phased array 13 light splitting with the spectrum after the first virtual image phased array 6 light splitting in sample arm 17, thereby along row different on the y axle corresponding to probe units different on sample 8, reduce the horizontal information of sample 8, realized the spectrum decoding; And the delegation's pectination spectrum that distributes at the x axle is corresponding to the interference spectrum of a probe unit on sample 8, the axial information of having carried this probe unit.For example the spectrum that forms of A1, A2, A3, A4, A5 is corresponding to probe unit A, and the spectrum that B1, B2, B3, B4, B5 form is corresponding to probe unit B.The imaging to multirow pectination spectrum time the by high speed face array CCD or high-speed area array CMOS16, realized that parallel interference spectrum surveys.
Claims (1)
1., based on the optical spectrum encoded and parallel OCT detection system quadrature light splitting, comprise wideband light source, optical circulator, broadband optical fiber coupler, the first fiber collimating lenses, the second fiber collimating lenses, the 3rd fiber collimating lenses, the first cylindrical focusing lens, the second cylindrical focusing lens, the first condenser lens, the second condenser lens, the first virtual image phased array, the second virtual image phased array, grating, sample, plane mirror, high speed face array CCD or high-speed area array CMOS;
It is characterized in that: wideband light source low-coherent light out, incide broadband optical fiber coupler through optical circulator, a road light enters sample arm after light splitting; Described sample arm: the light after the broadband optical fiber coupler light splitting incides the cylinder of the first cylindrical focusing lens through the first fiber collimating lenses, plane outgoing from the first cylindrical focusing lens, the light of outgoing converges to the entrance window of the first virtual image phased array front surface, rear surface outgoing from the first virtual image phased array, shine sample after the first condenser lens, the light that reflects from sample is back to broadband optical fiber coupler via former road;
Another road light after the broadband optical fiber coupler light splitting enters reference arm; Described reference arm: the light after the broadband optical fiber coupler light splitting shines plane mirror through the second fiber collimating lenses, and the light that reflects from plane mirror is back to broadband optical fiber coupler via former road;
Form interference light the two-way light that returns from sample arm and reference arm is interfered broadband optical fiber coupler after, through optical circulator, enter feeler arm, by feeler arm, interference light is decomposed into the interference spectrum signal; Described feeler arm: interference light is through the 3rd fiber collimating lenses, incide the cylinder of the second cylindrical focusing lens, plane outgoing from the second cylindrical focusing lens, the light of outgoing converges to the entrance window of the second virtual image phased array front surface, rear surface outgoing from the second virtual image phased array, carry out the first order light splitting on spatial domain, reenter and be mapped to grating, carry out second level light splitting on the orthogonal intersection space direction,, through the second condenser lens imaging, adopt high speed face array CCD or high-speed area array CMOS to carry out parallel detecting; Last these spectral signals change the signal of telecommunication into and import computer into, and implement Fourier transform scheduling algorithm processing reconstructed sample image in computer.
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103271721A (en) * | 2013-05-17 | 2013-09-04 | 浙江大学 | Method and system for detecting parallel OCT based on spectrum coding and orthogonal light splitting |
| CN110336928A (en) * | 2019-03-15 | 2019-10-15 | 浙江工业大学 | A kind of OCT spectroscopic acquisition and Transmission system based on ZYNQ |
| CN110913755A (en) * | 2017-07-19 | 2020-03-24 | 高露洁-棕榄公司 | Compact imaging system and method thereof |
| CN115639198A (en) * | 2022-11-15 | 2023-01-24 | 南京理工大学 | Full-field optical space-time coherent coding dynamic volume imaging device and method |
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2013
- 2013-05-17 CN CN2013202759741U patent/CN203280368U/en not_active Withdrawn - After Issue
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103271721A (en) * | 2013-05-17 | 2013-09-04 | 浙江大学 | Method and system for detecting parallel OCT based on spectrum coding and orthogonal light splitting |
| CN103271721B (en) * | 2013-05-17 | 2014-11-05 | 浙江大学 | Method and system for detecting parallel OCT based on spectrum coding and orthogonal light splitting |
| CN110913755A (en) * | 2017-07-19 | 2020-03-24 | 高露洁-棕榄公司 | Compact imaging system and method thereof |
| CN110336928A (en) * | 2019-03-15 | 2019-10-15 | 浙江工业大学 | A kind of OCT spectroscopic acquisition and Transmission system based on ZYNQ |
| CN115639198A (en) * | 2022-11-15 | 2023-01-24 | 南京理工大学 | Full-field optical space-time coherent coding dynamic volume imaging device and method |
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