CN208551741U - Rapid tissue molecular imaging device - Google Patents
Rapid tissue molecular imaging device Download PDFInfo
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- CN208551741U CN208551741U CN201720889583.7U CN201720889583U CN208551741U CN 208551741 U CN208551741 U CN 208551741U CN 201720889583 U CN201720889583 U CN 201720889583U CN 208551741 U CN208551741 U CN 208551741U
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Abstract
The embodiments of the present invention provide a kind of rapid tissue molecular imaging device, including light emitting unit, steering unit, scanning element and linear array probe unit, wherein the light emitting unit is for emitting Line beam；The steering unit is used to turn to the Line beam and the fluorescence through sample；The scanning element is used to adjust the direction of the Line beam turned to to progressively scan sample；And the linear array probe unit is for acquiring the fluorescence.The rapid tissue molecular imaging device excites sample using linear light source, is scanned using one-dimensional scanning unit to Line beam, and using linear array probe unit to sample excitation optical detection, realizes that copolymerization is burnt in one-dimensional square.Due to combining with linear array probe unit progress tissue element imaging using Line beam, the image taking speed of tissue element can be greatly improved, it can be achieved that real time imagery, and since scanning element only carries out one-dimensional scanning, can effectively improve the stability of system.
Description
Technical field
The utility model relates to medical instruments fields, relate more specifically to a kind of rapid tissue molecular imaging device.
Background technique
Tumour is to seriously threaten the major disease of human health.A large number of studies show that 90% or more tumour derives from epithelium
The lesion of cell, and the variation of molecule and cellular level can occur during cancer occurrence and development.High score based on fiber optic bundle
Resolution optics based endoscopic imaging technology, can reach the resolution ratio of micron or sub-micron, make scope amplification factor up to 1000 times, relatively
In other medical imaging technologies (such as CT, MRI, PET) have it is lossless, real-time, physical examination micrometer little tumour venereal disease become etc. technologies
Advantage can preferably improve the early diagnostic rate of tumour.The sound end of based endoscopic imaging can be deep into inside living body, complete micron
Grade is detected in body real non-destructive, realizes " in body biopsy " without sampling, and new skill is carried out for early stage cellular elements lesion surveying tape
Art means.
Utility model content
The utility model is proposed in view of the above problem.The utility model provides a kind of rapid tissue molecular imaging
Device, including light emitting unit, steering unit, scanning element and linear array probe unit, wherein the light emitting unit is for sending out
Ray beam；The steering unit is used to turn to the Line beam and the fluorescence through sample；The scanning element is for adjusting
The direction of the Line beam of steering is to progressively scan sample；And the linear array probe unit is for acquiring the fluorescence.
Illustratively, the light emitting unit includes: light source, for emitting collimated light beam；And line focus device is expanded, if
It sets in the exit of the light source, is Line beam for the collimated light beam to be expanded simultaneously one-dimensional focusing.
Illustratively, the steering unit is dichroscope.
Illustratively, the scanning element is single scanning galvanometer.
Illustratively, the scanning element is spatial light modulator.
Illustratively, described device further include be arranged in the scanning element downstream relay unit and it is interior peep unit,
Described in relay unit be used for by the scanning element scanning after Line beam focus on it is described in peep unit；Unit is peeped in described
For the Line beam of focusing is conducted and is focused on sample and receive sample sending fluorescence；The fluorescence is through the relaying
It is acquired after unit, the scanning element and the steering unit by the linear array probe unit.
Illustratively, the interior unit of peeping includes coupling object lens and imaging optical fiber bundle, wherein couplings mirror setting exists
One end of the imaging optical fiber bundle, for the Line beam of the focusing to be coupled into the proximal end of the fiber optic bundle；And it is described
Imaging optical fiber bundle is used to conduct the Line beam entered.
Illustratively, peeping unit in described further includes miniature object lens, and the miniature object lens are arranged in the imaging harness
The other end, the Line beam for conducting the fiber optic bundle focuses on the sample.
Illustratively, the linear array probe unit includes the condenser lens and linear array detector set gradually, wherein described
Condenser lens is used for the fluorescent foci for issuing the sample；And the linear array detector is used to acquire the fluorescence letter after focusing
Number.
Illustratively, the linear array probe unit further includes slit, and the slit is for only allowing the fluorescence of focussing plane
Pass through.
Illustratively, the linear array probe unit further includes optical filter, optical filter setting in the condenser lens and
Between the linear array detector, for filtering out stray light.
The rapid tissue molecular imaging device excites sample using linear light source, using one-dimensional scanning unit to linear light
Beam is scanned, and using linear array probe unit to sample excitation optical detection, realizes that copolymerization is burnt in one-dimensional square.Due to using line
Light beam is combined with linear array probe unit carries out tissue element imaging, can greatly improve the image taking speed of tissue element, can be real
Existing real time imagery, and since scanning element only carries out one-dimensional scanning, it can effectively improve the stability of system.
Detailed description of the invention
The utility model embodiment is described in more detail in conjunction with the accompanying drawings, the utility model above-mentioned and its
Its purpose, feature and advantage will be apparent.Attached drawing is used to provide to further understand the utility model embodiment, and
And part of specification is constituted, it is used to explain the utility model together with the utility model embodiment, not constitute to this reality
With novel limitation.In the accompanying drawings, identical reference label typically represents same or similar component or step.
Fig. 1 shows the schematic block diagram of the rapid tissue molecular imaging device according to the utility model one embodiment；
Fig. 2 shows the light path schematic diagrams according to the rapid tissue molecular imaging device of the utility model one embodiment.
Specific embodiment
In order to enable the purpose of this utility model, technical solution and advantage become apparent, retouch in detail below with reference to accompanying drawings
State example embodiment according to the present utility model.Obviously, described embodiment is only that a part of the utility model is implemented
Example, rather than the whole embodiments of the utility model, it should be appreciated that the utility model is not by the limit of example embodiment described herein
System.Based on the utility model embodiment described in the utility model, those skilled in the art are not being made the creative labor
In the case where obtained all other embodiment should all fall within the protection scope of the utility model.
Fig. 1 and Fig. 2 schematically shows the rapid tissue molecular imaging according to the utility model one embodiment
The block diagram and index path of device 100.The rapid tissue molecular imaging device 100 include light emitting unit 110, steering unit 120,
Scanning element 130 and linear array probe unit 160.The rapid tissue molecular imaging device 100 can be widely applied to alimentary canal, breathing
The tissue element at each position such as road is imaged, and realizes the early diagnosis of tumour.
Light emitting unit 110 is for emitting Line beam.In one embodiment, light emitting unit 110 may include light source
112 and expand line focus device 114.Light source 112 is for emitting collimated light beam.Light source 112 can be the collimation of transmitting specific wavelength
The laser of laser.The particular range of wavelengths can be 20nm-2000nm.Laser in the wave-length coverage can excite greatly
The fluorophor of range.Light source 112 can be quantum-well laser, solid-state laser, gas laser (such as argon laser
Device) or laser diode.Expand the outlet that light source 112 is arranged in line focus device 114, the collimation for issuing light source 112
Beam expander and one-dimensional focusing are Line beam.Expanding line focus device 114 may include extender lens and cylindrical lens.Extender lens can
To include two L1, L2, two extender lens L1, L2 cooperations expand the collimated light beam that light source 112 issues, to change standard
The diameter of collimated optical beam.Cylindrical lens include L3, and the light beam one-dimensional focusing after expanding is Line beam and conducts to steering unit
120。
Steering unit 120 is located at the downstream of light emitting unit 110, for turning to the Line beam of the transmitting of light emitting unit 110,
And the Fluoroscopic of sample can be made.In fig 1 and 2, solid line is used to indicate the Line beam that light emitting unit 110 issues, empty
Line is used to indicate that sample to be excited the fluorescence issued.Light and sample of the steering unit 120 for the sending of discrete light-emissive unit 110 swash
Send out the fluorescence generated.Steering unit 120 can achieve 90% or more to the transmissivity of fluorescence, and basic for the light of other wavelength
Upper all reflections.Then, the Line beam that light emitting unit 110 issues is being reflected to scanning element by steering unit 120
130.The fluorescence returned along optical path identical with Line beam is transmitted when passing through steering unit 120, and is conducted single to linear array detection
Member 160.The steering unit 120 for meeting above-mentioned condition can be dichroscope.Preferably, the wave-length coverage of the dichroscope can be with
In 40nm-2200nm wave-length coverage.
Scanning element 130 is located at the downstream of steering unit 120, one-dimensional sweeping is carried out to the Line beam of steering, for adjusting
The direction of the Line beam of steering is to progressively scan sample.Specifically, Line beam can be the Line beam for example extended in X direction,
The Line beam is redirect to the optical component (such as relay unit 140) in downstream by scanning element 130, while carrying out Y-direction scanning.
Y-direction is angled with X-direction, such as at 90 degree of right angle.Scanning element 130 is substantially carried out the one-dimensional scanning of Y-direction.
In this way, entire image can be formed with the scanning in a Line beam cooperation Y-direction of progress for X-direction.It can be seen that using
Line beam combination linear array probe unit 160 can be imaged line by line, therefore compared to existing point-by-point imaging, image taking speed is able to greatly
Width improves.For example, existing point-by-point imaging system can only obtain a point on image every time, it is assumed that 1 point was imaged
Time is 1 μ s, for the image of 512*512 pixel, then the 1 μ s*512*512=of time needed at entire image
0.26s, about can be at 4 width images in 1 second；And for linear scanning system provided by the present application, one can disposably be obtained by shooting 1 time
Row image theoretically just improves 512 times than originally.Assuming that the camera single exposure time is 40 μ s, then when at piece image
Between be 40 μ s*512=0.02s, about can be at 50 width images in 1 second.Further, since only carrying out the sweeping in one-dimensional square, sweep
Retouching unit 130 can be single scanning galvanometer.The frequency of scanning galvanometer can be in the frequency range of 10-2000KHz.It is single
Noise, and the complexity of the composition of compact device and control can be greatly reduced in the use of a scanning galvanometer, improve complete machine
Stability, while reducing manufacturing cost and maintenance cost.In addition, scanning element 130 or spatial light modulator.Space
Optical modulator compared to scanning galvanometer for, the cost is relatively high.
The rapid tissue molecular imaging device 100 further includes 140 He of relay unit that 130 downstream of scanning element is arranged in
Inside peep unit 150.
Relay unit 140 peeps unit 150 in being used to focus on the Line beam after the scanning of scanning element 130.Relay unit
140 be usually lens group, such as lens L4, L5.
Unit 150 is inside peeped for conducting and focusing on sample for the Line beam that relay unit 140 focuses, and receives sample
The fluorescence that product issue.It is acquired after the relayed unit 140 of the fluorescence and steering unit 120 by linear array probe unit 160.Inside peep unit
150 may include coupling object lens 152, miniature object lens 156 and and being coupled between coupling object lens 152 and miniature object lens 156
Imaging optical fiber bundle 154.Relay unit 140 may include two relay lens L4, L5, they cooperate the linear light after scanning
Beam peeps the rear pupil for coupling object lens 152 in unit 150 in being relayed to.Couple object lens 152 be used for Line beam coupling is (such as poly-
It is burnt) enter the proximal end of imaging optical fiber bundle 154 (close to one end of operator).Imaging optical fiber bundle 154 is for conducting Line beam
To the distal end (one end far from operator) of imaging optical fiber bundle 154.Miniature object lens 156 are for conducting imaging optical fiber bundle 154
Laser focus in the detection faces of sample.Detection faces can be located at sample surfaces required depth below.The inspection of sample
The fluorogen at survey face place is excited to issue fluorescence.Fluorescence signal is collected by miniature object lens 156, imaged fiber optic bundle 154, couplings
Mirror 152 and relay unit 140 conduct, and scanning element 130 reflects, and pass through steering unit 120 and enter linear array probe unit 160.At
The quantity of the light shafts as included by fiber optic bundle 154 can be greater than ten.Miniature object lens 156 are not required.To clarity
In the case where of less demanding, it is alternatively possible to omit miniature object lens 156.Miniature object lens 156 can be designed to that digestion can be extend into
In road, respiratory tract etc., it is in contact with the surface of alimentary canal, respiratory tract etc..
In detection optical path, linear array probe unit 160, which acquires, peeps unit 150, relay unit 140, scanning list in successively warp
The fluorescence that member 130 and steering unit 120 return.In a preferred embodiment, linear array probe unit 160 includes condenser lens
162 and linear array detector 166.Condenser lens 162 is used for the fluorescent foci for issuing sample.Linear array detector 166 is for acquiring
Fluorescence signal after the focusing of condenser lens 162.Fluorescence after focusing is photosensitive on the photosurface of linear array detector 166.Linear array is visited
Surveying device 166 can be various types of line-scan digital cameras, such as CCD (charge coupled cell) line-scan digital camera or CMOS (complementary metal
Oxide semiconductor) line-scan digital camera etc..The image taking speed of linear array detector 166 is in the range of tens frames to several ten million frames.
Optionally, slit 164 can be set between condenser lens 162 and linear array detector 166, slit 164 is used for
Only the fluorescence of focussing plane is allowed to pass through.The size of slit 164 can be in the range of tens nanometers to tens millimeters.Slit
164 presence is blocked the stray light outside focussing plane.Illuminate what sample issued by Line beam only on focussing plane
Fluorescence is received, and by the scanning of scanning element 130, the fluorescence that the sample of all rows of sample issues at focussing plane is all by line
Array detector 166 receives, and according to the trajectory alignment of scanning at two dimensional image, and then can fast implement observable tissue element
Image.Optionally, linear array probe unit 160 includes optical filter.The setting of optical filter (not shown) is visited in condenser lens 162 and linear array
It surveys between device 166, for filtering out stray light.In the embodiment for having slit 164, optical filter be can be set in condenser lens 162
Between slit 164.
In summary, the collimated light beam that light source 112 issues is expanded line focus device 114 and expands and one-dimensional pool linear light
Beam, steering unit 120 turn back Line beam, scanning element 130 by Line beam by relay unit 140 be coupled into peep unit
150, it inside peeps unit 150 and conducts laser beam to sample, inspire fluorescence and be passed back to linear array probe unit 160 being imaged.
Illustratively, the collected data of linear array detector can be sent to computer, be received and processed by computer.This
Outside, which can also send out scanning element (such as frequency of galvanometer etc.), the exposure of linear array detector and gain and light
The transmission power etc. for penetrating unit is controlled.
The rapid tissue molecular imaging device 100 excites sample using linear light source, using one-dimensional scanning unit 130
(such as single scanning galvanometer) is scanned Line beam, and using linear array probe unit 160 to sample excitation optical detection,
One-dimensional square realizes that copolymerization is burnt.Tissue element imaging is carried out due to combining using Line beam with linear array probe unit 160, it can
To greatly improve the image taking speed of tissue element, it can be achieved that real time imagery, and since scanning element 130 only carries out one-dimensional sweep
It retouches, therefore can effectively improve the stability of system.
Although describing example embodiment by reference to attached drawing here, it should be understood that above example embodiment are only exemplary
, and be not intended to the scope of the utility model limited to this.Those of ordinary skill in the art can carry out various wherein
Change and modify, without departing from the scope of the utility model and spirit.All such changes and modifications are intended to be included in appended
Within the scope of the utility model required by claim.
In several embodiments provided herein, it should be understood that disclosed device and method can pass through it
Its mode is realized.For example, apparatus embodiments described above are merely indicative, for example, the division of the unit, only
Only a kind of logical function partition, there may be another division manner in actual implementation, such as multiple units or components can be tied
Another equipment is closed or is desirably integrated into, or some features can be ignored or not executed.
In the instructions provided here, numerous specific details are set forth.It is to be appreciated, however, that the utility model
Embodiment can be practiced without these specific details.In some instances, be not been shown in detail well known method,
Structure and technology, so as not to obscure the understanding of this specification.
Similarly, it should be understood that in order to simplify the utility model and help to understand one in each utility model aspect
Or it is multiple, in the description to the exemplary embodiment of the utility model, each feature of the utility model is divided together sometimes
Group is into single embodiment, figure or descriptions thereof.However, the method for the utility model should not be construed to reflect
Following to be intended to: the requires of the utility model i.e. claimed is more more than feature expressly recited in each claim
Feature.More precisely, practical novel point is can be with less than some as corresponding claims reflect
The features of all features of disclosed single embodiment solves corresponding technical problem.Therefore, it then follows specific embodiment
Thus claims are expressly incorporated in the specific embodiment, wherein each claim itself is as the utility model
Separate embodiments.
It will be understood to those skilled in the art that any combination pair can be used other than mutually exclusive between feature
All features disclosed in this specification (including adjoint claim, abstract and attached drawing) and so disclosed any method
Or all process or units of equipment are combined.Unless expressly stated otherwise, this specification (is wanted including adjoint right
Ask, make a summary and attached drawing) disclosed in each feature can be replaced with an alternative feature that provides the same, equivalent, or similar purpose.
In addition, it will be appreciated by those of skill in the art that although some embodiments described herein include other embodiments
In included certain features rather than other feature, but the combination of the feature of different embodiments mean it is practical new in this
Within the scope of type and form different embodiments.For example, in detail in the claims, embodiment claimed it is any
One of can in any combination mode come using.
The utility model is limited it should be noted that above-described embodiment illustrates rather than the utility model,
And those skilled in the art can be designed alternative embodiment without departing from the scope of the appended claims.In right
In it is required that, any reference symbol between parentheses should not be configured to limitations on claims.Word "comprising" is not arranged
Except there are element or steps not listed in the claims.Word "a" or "an" located in front of the element does not exclude the presence of more
A such element.The utility model can be by means of including the hardware of several different elements and by means of properly programmed
Computer is realized.In the unit claims listing several devices, several in these devices can be by same
One hardware branch embodies.The use of word first, second, and third does not indicate any sequence.It can be by these lists
Word is construed to title.
Above description is only a specific implementation of the present invention or to the explanation of specific embodiment, this is practical new
The protection scope of type is not limited thereto, the technology model that anyone skilled in the art discloses in the utility model
In enclosing, it can easily think of the change or the replacement, should be covered within the scope of the utility model.The protection of the utility model
Range should be subject to the protection scope in claims.
Claims (11)
1. a kind of rapid tissue molecular imaging device, including light emitting unit, steering unit, scanning element and linear array detection are single
Member, in which:
The light emitting unit is for emitting Line beam；
The steering unit is used to turn to the Line beam and the fluorescence through sample；
The scanning element is used to adjust the direction of the Line beam turned to to progressively scan sample；And
The linear array probe unit is for acquiring the fluorescence.
2. device as described in claim 1, wherein the light emitting unit includes:
Light source, for emitting collimated light beam；And
Line focus device is expanded, the exit of the light source is set, is line for the collimated light beam to be expanded simultaneously one-dimensional focusing
Light beam.
3. device as described in claim 1, wherein the steering unit is dichroscope.
4. device as described in claim 1, wherein the scanning element is single scanning galvanometer.
5. device as described in claim 1, wherein the scanning element is spatial light modulator.
6. device as described in claim 1, wherein described device further includes the relaying list that the scanning element downstream is arranged in
It is first and it is interior peep unit, wherein
The relay unit, which is used to focus on the Line beam after scanning element scanning in described, peeps unit；
The fluorescence that unit is used to conduct and focus on sample for the Line beam of focusing and receive sample sending is peeped in described；
The fluorescence is adopted after the relay unit, the scanning element and the steering unit by the linear array probe unit
Collection.
7. device as claimed in claim 6, wherein unit is peeped in described includes coupling object lens and imaging optical fiber bundle, wherein
One end of the imaging optical fiber bundle is arranged in the coupling object lens, described for the Line beam of the focusing to be coupled into
The proximal end of fiber optic bundle；And
The imaging optical fiber bundle is used to conduct the Line beam entered.
8. device as claimed in claim 7, wherein peeping unit in described further includes miniature object lens, the miniature object lens setting
In the other end of the imaging optical fiber bundle, the Line beam for conducting the fiber optic bundle focuses on the sample.
9. device as described in claim 1, wherein the linear array probe unit includes the condenser lens set gradually and linear array
Detector, wherein
The condenser lens is used for the fluorescent foci for issuing the sample；And
The linear array detector is used to acquire the fluorescence signal after focusing.
10. device as claimed in claim 9, wherein the linear array probe unit further includes slit, and the slit is for only permitting
Perhaps the fluorescence of focussing plane passes through.
11. device as claimed in claim 9, wherein the linear array probe unit further includes optical filter, the optical filter setting
Between the condenser lens and the linear array detector, for filtering out stray light.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720889583.7U CN208551741U (en) | 2017-07-20 | 2017-07-20 | Rapid tissue molecular imaging device |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201720889583.7U CN208551741U (en) | 2017-07-20 | 2017-07-20 | Rapid tissue molecular imaging device |
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| CN208551741U true CN208551741U (en) | 2019-03-01 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107361725A (en) * | 2017-07-20 | 2017-11-21 | 无锡海斯凯尔医学技术有限公司 | Rapid tissue molecular imaging device |
-
2017
- 2017-07-20 CN CN201720889583.7U patent/CN208551741U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107361725A (en) * | 2017-07-20 | 2017-11-21 | 无锡海斯凯尔医学技术有限公司 | Rapid tissue molecular imaging device |
| CN107361725B (en) * | 2017-07-20 | 2024-02-27 | 无锡海斯凯尔医学技术有限公司 | Quick tissue molecule imaging device |
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