CN108473963A - 用于异种移植的多重转基因猪 - Google Patents

用于异种移植的多重转基因猪 Download PDF

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CN108473963A
CN108473963A CN201680065556.6A CN201680065556A CN108473963A CN 108473963 A CN108473963 A CN 108473963A CN 201680065556 A CN201680065556 A CN 201680065556A CN 108473963 A CN108473963 A CN 108473963A
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gene
expression
transgenic
locus
transgenes
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D.L.阿亚雷斯
C.菲尔普斯
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Revivicor Inc
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Revivicor Inc
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Priority to CN202210920541.0A priority Critical patent/CN115380872A/zh
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CN201680065556.6A 2015-09-09 2016-09-09 用于异种移植的多重转基因猪 Pending CN108473963A (zh)

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CN202210920541.0A CN115380872A (zh) 2015-09-09 2016-09-09 用于异种移植的多重转基因猪

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US201562216225P 2015-09-09 2015-09-09
US62/216225 2015-09-09
US201562256068P 2015-11-16 2015-11-16
US62/256068 2015-11-16
PCT/US2016/051126 WO2017044864A1 (en) 2015-09-09 2016-09-09 Multi-transgenic pig for xenotransplantation

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US (1) US20180249688A1 (https=)
EP (1) EP3347458A4 (https=)
JP (4) JP7050665B2 (https=)
KR (2) KR20250161669A (https=)
CN (2) CN108473963A (https=)
AU (3) AU2016319131B2 (https=)
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Cited By (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110305872A (zh) * 2019-07-17 2019-10-08 中国农业科学院北京畜牧兽医研究所 小型猪2型糖尿病模型的构建方法及应用
CN110373389A (zh) * 2019-06-10 2019-10-25 云南农业大学 一种适合胰岛细胞及皮肤等组织异种移植供体猪的构建方法
CN110373391A (zh) * 2019-06-10 2019-10-25 云南农业大学 一种适合心脏异种移植供体猪的构建方法
CN110373392A (zh) * 2019-06-10 2019-10-25 云南农业大学 一种适合肾脏异种移植供体猪的构建方法
CN111778251A (zh) * 2020-07-14 2020-10-16 金佩奇生物科技(南京)有限公司 敲除猪异种抗原的基因的gRNA及其应用
CN111955422A (zh) * 2020-08-21 2020-11-20 五邑大学 一种可用于异种器官移植的供体猪的构建方法
CN112741046A (zh) * 2019-10-31 2021-05-04 成都中医药大学附属医院 一种copd合并气管支气管软化症模型的构建方法
CN113368306A (zh) * 2020-03-23 2021-09-10 成都中科奥格生物科技有限公司 低免疫原性生物材料及其制备方法和用途
CN113429475A (zh) * 2020-03-23 2021-09-24 成都中科奥格生物科技有限公司 一种胶原材料及其制备方法和用途
CN115003817A (zh) * 2019-07-23 2022-09-02 致优制药有限公司 猪内源性逆转录病毒包膜C为阴性、GGTA1、CMAH、iGb3s及β4GalNT2基因被敲除并且表达人类CD46及TBM基因的异种器官移植用转基因克隆猪及其制备方法
CN115176020A (zh) * 2019-05-16 2022-10-11 E开创生物技术股份有限公司 具有一个或多个用于增强异种移植物存活和/或耐受性的经修饰基因的细胞、组织、器官和/或动物
CN115232813A (zh) * 2021-07-15 2022-10-25 南京启真基因工程有限公司 用于构建vWF基因突变的血管性血友病模型猪核移植供体细胞的基因编辑系统及其应用
CN115605585A (zh) * 2020-01-07 2023-01-13 杭州启函生物科技有限公司（Cn） 产生异种胰岛细胞和用所述异种胰岛细胞治疗胰岛素抗性或缺乏性病症的方法和组合物
CN117099743A (zh) * 2023-07-11 2023-11-24 吉林大学 一种snx6基因不表达的异种移植供体及制备方法
CN117279502A (zh) * 2020-11-20 2023-12-22 雷维维科公司 用于异种移植的生长激素受体敲除的多转基因猪

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US10704021B2 (en) 2012-03-15 2020-07-07 Flodesign Sonics, Inc. Acoustic perfusion devices
WO2015105955A1 (en) 2014-01-08 2015-07-16 Flodesign Sonics, Inc. Acoustophoresis device with dual acoustophoretic chamber
WO2016126831A1 (en) 2015-02-03 2016-08-11 Mayo Foundation For Medical Education And Research Methods and materials for assessing and treating arthritis
US11708572B2 (en) 2015-04-29 2023-07-25 Flodesign Sonics, Inc. Acoustic cell separation techniques and processes
US11377651B2 (en) 2016-10-19 2022-07-05 Flodesign Sonics, Inc. Cell therapy processes utilizing acoustophoresis
CN107921148A (zh) 2015-05-08 2018-04-17 哈佛学院校长同事会 通用供体干细胞和相关方法
US11214789B2 (en) 2016-05-03 2022-01-04 Flodesign Sonics, Inc. Concentration and washing of particles with acoustics
WO2018041118A1 (en) 2016-08-31 2018-03-08 Beijing Biocytogen Co., Ltd Genetically modified non-human animal with human or chimeric pd-l1
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