CN108473549A - 单链gitr受体激动剂蛋白 - Google Patents
单链gitr受体激动剂蛋白 Download PDFInfo
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- CN108473549A CN108473549A CN201680073664.8A CN201680073664A CN108473549A CN 108473549 A CN108473549 A CN 108473549A CN 201680073664 A CN201680073664 A CN 201680073664A CN 108473549 A CN108473549 A CN 108473549A
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70575—NGF/TNF-superfamily, e.g. CD70, CD95L, CD153, CD154
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
- C07K2319/22—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a Strep-tag
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/35—Fusion polypeptide containing a fusion for enhanced stability/folding during expression, e.g. fusions with chaperones or thioredoxin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
- C07K2319/74—Fusion polypeptide containing domain for protein-protein interaction containing a fusion for binding to a cell surface receptor
Landscapes
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
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- Biomedical Technology (AREA)
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- Wood Science & Technology (AREA)
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- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
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- Physics & Mathematics (AREA)
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- Pain & Pain Management (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Oncology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562245815P | 2015-10-23 | 2015-10-23 | |
| US62/245,815 | 2015-10-23 | ||
| PCT/EP2016/075552 WO2017068185A1 (en) | 2015-10-23 | 2016-10-24 | Single-chain gitr-receptor agonist proteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108473549A true CN108473549A (zh) | 2018-08-31 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680073664.8A Pending CN108473549A (zh) | 2015-10-23 | 2016-10-24 | 单链gitr受体激动剂蛋白 |
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| Country | Link |
|---|---|
| US (2) | US10533043B2 (enExample) |
| EP (1) | EP3365363A1 (enExample) |
| JP (1) | JP6959229B2 (enExample) |
| CN (1) | CN108473549A (enExample) |
| AU (1) | AU2016341402B2 (enExample) |
| CA (1) | CA3002741A1 (enExample) |
| WO (1) | WO2017068185A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MA41460A (fr) | 2015-02-03 | 2017-12-12 | Oncomed Pharm Inc | Agents de liaison à la tnfrsf et leurs utilisations |
| JP7274426B2 (ja) | 2017-05-16 | 2023-05-16 | ブリストル－マイヤーズ スクイブ カンパニー | 抗ｇｉｔｒアゴニスト抗体での癌の処置 |
| US20230212260A1 (en) | 2020-05-15 | 2023-07-06 | Apogenix Ag | Multi-specific immune modulators |
| WO2023088876A1 (en) | 2021-11-16 | 2023-05-25 | Apogenix Ag | Multi-specific immune modulators |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1326467A (zh) * | 1998-08-25 | 2001-12-12 | 利思进药品公司 | 表达以及分泌制管张素和endostatin的免疫融合物 |
| CN1602358A (zh) * | 2001-05-08 | 2005-03-30 | 阿波克西斯公司 | 重组融合蛋白及其三聚体 |
| WO2005103077A1 (de) * | 2004-03-26 | 2005-11-03 | Universität Stuttgart | Rekombinante polypeptide der mitglieder der tnf ligandenfamilie und deren verwendung |
| WO2010010051A1 (en) * | 2008-07-21 | 2010-01-28 | Apogenix Gmbh | Tnfsf single chain molecules |
| CN102250250A (zh) * | 2011-07-09 | 2011-11-23 | 浙江大学 | 一种人鼠嵌合型抗人CD19抗体Hm2E8b及用途 |
| WO2013092983A2 (en) * | 2011-12-23 | 2013-06-27 | Innate Pharma | Enzymatic conjugation of polypeptides |
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| AU775422B2 (en) * | 1998-06-15 | 2004-07-29 | Gtc Biotherapeutics, Inc. | Erythropoietin analog-human serum albumin fusion |
| AU7645700A (en) | 1999-10-07 | 2001-05-10 | Maxygen Aps | Single-chain antagonist polypeptides |
| DE19963859A1 (de) | 1999-12-30 | 2001-07-12 | Apotech Res & Dev Ltd | Bi- oder Oligomer eines Di-, Tri-, Quattro- oder Pentamers von rekombinanten Fusionsproteinen |
| CA2314199A1 (en) | 2000-07-21 | 2002-01-21 | Robert Simoneau | C-chip |
| EP1746161A1 (en) * | 2005-07-20 | 2007-01-24 | Cytheris | Glycosylated IL-7, preparation and uses |
| ES2354954T3 (es) * | 2006-03-22 | 2011-03-21 | Viral Logic Systems Technology Corp. | Métodos para identificar dianas polipeptídicas. |
| JP5283104B2 (ja) * | 2007-01-10 | 2013-09-04 | 独立行政法人理化学研究所 | アセチル化及び脱アセチル化の蛍光可視化検出方法 |
| JP2010518140A (ja) * | 2007-02-14 | 2010-05-27 | グラクソ グループ リミテッド | Ｉｇｆ−１ｒに対する新規抗体 |
| CA2963124C (en) | 2007-07-10 | 2019-10-15 | Apogenix Ag | Tnf superfamily collectin fusion proteins |
| WO2009016164A1 (en) * | 2007-08-01 | 2009-02-05 | Glaxo Group Limited | Novel antibodies |
| SG191639A1 (en) | 2008-06-03 | 2013-07-31 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| US8664366B2 (en) | 2009-01-09 | 2014-03-04 | Apogenix Gmbh | Fusion proteins forming trimers |
| US8637637B2 (en) * | 2010-01-12 | 2014-01-28 | Bill Nai-Chau Sun | Fc fusion proteins of human growth hormone |
| NO2776305T3 (enExample) * | 2014-04-23 | 2018-01-27 | ||
| JP2014218510A (ja) * | 2014-08-11 | 2014-11-20 | アポゲニクスゲゼルシャフト ミット ベシュレンクテルハフツングＡｐｏｇｅｎｉｘ ＧｍｂＨ | 三量体形成融合タンパク質 |
-
2016
- 2016-10-24 WO PCT/EP2016/075552 patent/WO2017068185A1/en not_active Ceased
- 2016-10-24 CA CA3002741A patent/CA3002741A1/en not_active Abandoned
- 2016-10-24 EP EP16791342.5A patent/EP3365363A1/en not_active Withdrawn
- 2016-10-24 JP JP2018521289A patent/JP6959229B2/ja not_active Expired - Fee Related
- 2016-10-24 AU AU2016341402A patent/AU2016341402B2/en not_active Ceased
- 2016-10-24 CN CN201680073664.8A patent/CN108473549A/zh active Pending
-
2018
- 2018-04-19 US US15/957,279 patent/US10533043B2/en active Active
-
2020
- 2020-01-02 US US16/732,854 patent/US11149075B2/en not_active Expired - Fee Related
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1326467A (zh) * | 1998-08-25 | 2001-12-12 | 利思进药品公司 | 表达以及分泌制管张素和endostatin的免疫融合物 |
| CN1602358A (zh) * | 2001-05-08 | 2005-03-30 | 阿波克西斯公司 | 重组融合蛋白及其三聚体 |
| WO2005103077A1 (de) * | 2004-03-26 | 2005-11-03 | Universität Stuttgart | Rekombinante polypeptide der mitglieder der tnf ligandenfamilie und deren verwendung |
| WO2010010051A1 (en) * | 2008-07-21 | 2010-01-28 | Apogenix Gmbh | Tnfsf single chain molecules |
| CN102250250A (zh) * | 2011-07-09 | 2011-11-23 | 浙江大学 | 一种人鼠嵌合型抗人CD19抗体Hm2E8b及用途 |
| WO2013092983A2 (en) * | 2011-12-23 | 2013-06-27 | Innate Pharma | Enzymatic conjugation of polypeptides |
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| 顾镭等: "TNF-α诱导的人肺动脉内皮细胞GITRL的表达及意义", 《江苏医药》 * |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2016341402B2 (en) | 2020-08-27 |
| US20200123223A1 (en) | 2020-04-23 |
| US20180244752A1 (en) | 2018-08-30 |
| AU2016341402A1 (en) | 2018-05-10 |
| WO2017068185A1 (en) | 2017-04-27 |
| US11149075B2 (en) | 2021-10-19 |
| US10533043B2 (en) | 2020-01-14 |
| EP3365363A1 (en) | 2018-08-29 |
| JP6959229B2 (ja) | 2021-11-02 |
| JP2019501631A (ja) | 2019-01-24 |
| CA3002741A1 (en) | 2017-04-27 |
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