CN108472120B - 用于生物医学应用的聚合物材料 - Google Patents

用于生物医学应用的聚合物材料 Download PDF

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CN108472120B
CN108472120B CN201680069935.2A CN201680069935A CN108472120B CN 108472120 B CN108472120 B CN 108472120B CN 201680069935 A CN201680069935 A CN 201680069935A CN 108472120 B CN108472120 B CN 108472120B
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medical facility
monomers
formula
acid
oligomer
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CN108472120A (zh
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刘超
杨健
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Penn State Research Foundation
Aleo BME Inc
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Aleo BME Inc
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    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/48—Polyethers
    • C08G18/4833—Polyethers containing oxyethylene units
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/02—Polyesters derived from dicarboxylic acids and dihydroxy compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
    • A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
    • A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
    • A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/18—Macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/08—Processes
    • C08G18/10—Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/08—Processes
    • C08G18/16—Catalysts
    • C08G18/22—Catalysts containing metal compounds
    • C08G18/24—Catalysts containing metal compounds of tin
    • C08G18/244—Catalysts containing metal compounds of tin tin salts of carboxylic acids
    • C08G18/246—Catalysts containing metal compounds of tin tin salts of carboxylic acids containing also tin-carbon bonds
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/42—Polycondensates having carboxylic or carbonic ester groups in the main chain
    • C08G18/4236—Polycondensates having carboxylic or carbonic ester groups in the main chain containing only aliphatic groups
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/28—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the compounds used containing active hydrogen
    • C08G18/40—High-molecular-weight compounds
    • C08G18/42—Polycondensates having carboxylic or carbonic ester groups in the main chain
    • C08G18/4266—Polycondensates having carboxylic or carbonic ester groups in the main chain prepared from hydroxycarboxylic acids and/or lactones
    • C08G18/4269—Lactones
    • C08G18/4277—Caprolactone and/or substituted caprolactone
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G18/00—Polymeric products of isocyanates or isothiocyanates
    • C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
    • C08G18/70—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen characterised by the isocyanates or isothiocyanates used
    • C08G18/72—Polyisocyanates or polyisothiocyanates
    • C08G18/73—Polyisocyanates or polyisothiocyanates acyclic
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/04—Polyesters derived from hydroxycarboxylic acids, e.g. lactones
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L67/00—Compositions of polyesters obtained by reactions forming a carboxylic ester link in the main chain; Compositions of derivatives of such polymers
    • C08L67/06—Unsaturated polyesters
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L71/00—Compositions of polyethers obtained by reactions forming an ether link in the main chain; Compositions of derivatives of such polymers
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L75/00—Compositions of polyureas or polyurethanes; Compositions of derivatives of such polymers
    • C08L75/04—Polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00—Materials or treatment for tissue regeneration
    • A61L2430/32—Materials or treatment for tissue regeneration for nerve reconstruction
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2201/00—Properties
    • C08L2201/06—Biodegradable
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L2203/00—Applications
    • C08L2203/02—Applications for biomedical use

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Materials For Medical Uses (AREA)
  • Polyurethanes Or Polyureas (AREA)
  • Polyethers (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Biological Depolymerization Polymers (AREA)
CN201680069935.2A 2015-11-30 2016-11-29 用于生物医学应用的聚合物材料 Active CN108472120B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562260752P 2015-11-30 2015-11-30
US62/260,752 2015-11-30
PCT/US2016/064018 WO2017095816A1 (en) 2015-11-30 2016-11-29 Polymeric materials for biomedical applications

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Publication Number Publication Date
CN108472120A CN108472120A (zh) 2018-08-31
CN108472120B true CN108472120B (zh) 2022-02-25

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US (1) US11267965B2 (cg-RX-API-DMAC7.html)
EP (1) EP3383315B1 (cg-RX-API-DMAC7.html)
JP (1) JP7090027B2 (cg-RX-API-DMAC7.html)
CN (1) CN108472120B (cg-RX-API-DMAC7.html)
CA (1) CA3005306C (cg-RX-API-DMAC7.html)
WO (1) WO2017095816A1 (cg-RX-API-DMAC7.html)

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US10172974B2 (en) 2016-01-19 2019-01-08 The Penn State Research Foundation Antimicrobial polymers
CN109810666B (zh) * 2018-12-21 2020-10-30 中山市康和化工有限公司 一种具有降解特性的聚氨酯胶粘剂及其制备方法
CN109646159B (zh) * 2018-12-26 2021-02-05 上海纳米技术及应用国家工程研究中心有限公司 解剖型3d打印波纹管弹性体气管支架的制备方法及产品
CN109777090B (zh) * 2019-01-11 2021-02-19 齐鲁工业大学 一种有机聚合物/二氧化硅复合纳米膜及其制备方法
CN109971163B (zh) * 2019-04-04 2021-02-02 陕西科技大学 一种水性聚氨酯/Fe3+凝胶材料的制备方法
CA3163006A1 (en) * 2019-12-24 2021-07-01 Jian Yang Bioadhesive compositions and methods of making the same
AU2021253845A1 (en) * 2020-04-07 2022-10-06 The Penn State Research Foundation Xylitol-doped citrate compositions and uses thereof
CN111620997A (zh) * 2020-06-09 2020-09-04 林多炉 一种高强度的石墨烯改性聚氨酯导电材料及其制法
KR102553303B1 (ko) * 2020-07-08 2023-07-07 주식회사 아이센스 관능화된 열가소성 폴리우레탄, 이의 제조방법 및 이를 이용한 의료용 고기능성 복합재료의 제조 방법 및 이를 포함하는 의료장치
CN112029068B (zh) * 2020-09-08 2022-05-31 浙江德普斯医疗科技股份有限公司 聚氨酯化合物及其制备方法以及生物粘结剂
WO2022081856A1 (en) * 2020-10-16 2022-04-21 The Johns Hopkins University Biodegradable nanofiber conical conduits for nerve repair
WO2022136583A1 (en) * 2020-12-23 2022-06-30 Peters Surgical A hemostatic tissue adhesive composition comprising an nco-terminated urethane preprolymer
CN112940218B (zh) * 2021-02-04 2022-11-01 四川大学 可降解的电活性聚氨酯材料及其制备方法和应用
CN113817145B (zh) * 2021-05-20 2023-03-28 北京服装学院 一种基于聚ε-己内酯的聚酯型生物可降解形状记忆共聚物及其制备方法
CN113244451B (zh) * 2021-06-02 2022-06-03 青岛大学 一种仿生天然肌腱-骨梯度界面的补片材料及其制备方法
US20250090721A1 (en) * 2023-09-20 2025-03-20 Acuitive Technologies, Inc. Charged Citrate-Based Biomaterials
CN119680022B (zh) * 2025-02-21 2025-06-13 西湖大学 一种自粘接性材料和制备方法及其用途

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JP2009093565A (ja) * 2007-10-11 2009-04-30 Iseki & Co Ltd 乗用田植機
CN103751148A (zh) * 2014-01-10 2014-04-30 华南理工大学 一种以双亲性聚氨酯为载体的具有靶向和缓释作用的抗肿瘤药物纳米微球及其制备方法
WO2015035020A1 (en) * 2013-09-05 2015-03-12 The Penn State Research Foundation Bioelastomers and applications thereof
CN104470904A (zh) * 2012-02-28 2015-03-25 赛诺菲 官能化的pla-peg共聚物,其纳米颗粒,其制备及其用于靶向药物递送和造影的应用
CN104937096A (zh) * 2013-01-04 2015-09-23 德克萨斯系统大学董事会 包含柠檬酸的组合物及其应用

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Publication number Priority date Publication date Assignee Title
GB2394418A (en) * 2002-10-25 2004-04-28 Johnson & Johnson Medical Ltd Fluid wound dressing
JP2009093565A (ja) * 2007-10-11 2009-04-30 Iseki & Co Ltd 乗用田植機
CN104470904A (zh) * 2012-02-28 2015-03-25 赛诺菲 官能化的pla-peg共聚物,其纳米颗粒,其制备及其用于靶向药物递送和造影的应用
CN104937096A (zh) * 2013-01-04 2015-09-23 德克萨斯系统大学董事会 包含柠檬酸的组合物及其应用
WO2015035020A1 (en) * 2013-09-05 2015-03-12 The Penn State Research Foundation Bioelastomers and applications thereof
CN103751148A (zh) * 2014-01-10 2014-04-30 华南理工大学 一种以双亲性聚氨酯为载体的具有靶向和缓释作用的抗肿瘤药物纳米微球及其制备方法

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US20180340063A1 (en) 2018-11-29
EP3383315B1 (en) 2023-09-27
WO2017095816A1 (en) 2017-06-08
CA3005306C (en) 2021-08-10
CN108472120A (zh) 2018-08-31
US11267965B2 (en) 2022-03-08
EP3383315A4 (en) 2019-06-19
EP3383315A1 (en) 2018-10-10
JP7090027B2 (ja) 2022-06-23
CA3005306A1 (en) 2017-06-08
JP2019504922A (ja) 2019-02-21

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