CN108452011A - 一种复方植物精华提取物的组合物及其制备方法 - Google Patents
一种复方植物精华提取物的组合物及其制备方法 Download PDFInfo
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Abstract
本发明属于护肤用品技术领域，具体涉及一种复方植物精华提取物的组合物及其制备方法。该复方植物精华提取物由翼籽辣木籽提取物0.5‑15份、红花提取物1‑12份、川芎提取物1‑12份、迷迭香花提取物1‑12份、丹参提取物0‑18份、三七根提取物1‑12份、独活提取物1‑12份、香叶天竺葵花油1‑40份、路路通提取物1‑12份、辣薄荷提取物1‑8份、凤仙花叶提取物1‑12份、薄荷脑0.01‑0.1份制成。该组合物涂抹于关节、颈肩部以及肌肉酸痛处能够活血祛瘀，有效缓解酸痛。
Description
技术领域
本发明属于护肤用品技术领域，具体涉及一种复方植物精华提取物的组合物及其制备方法。
背景技术
随着人们生活节奏的加快，学习、工作等诸多压力使得越来越多的人出现亚健康状态，常表现为浑身乏力、肌肉酸痛等症状。另外由于各种原因引起的关节疼痛也给人们的工作和生活带来了许多不便。中医学认为，经络遍布全身，为一身之通路，气血津液皆循经络而行，通则不痛，痛则不通。各种关节与肌肉的酸痛也可用经络不通来解释，可通过舒筋活血、行气止痛、温通经络而缓解症状。
辣木为高钙、高蛋白质、高纤维、低脂质，具有增强体力、治疗贫血、抑制病菌、驱除寄生虫等功效，被誉为“生命之树”。研究发现，辣木籽水醇提取物、辣木根或叶的甲醇提取物具有一定的抗炎活性，辣木中的异硫氰酸酯能够抵消炎症级联反应，有效对抗促炎细胞因子；异硫氰酸盐、苯甲基异硫氰酸盐、异硫氰酸酯能够抑制TNF-a和IL-2的产生；辣木的乙酸乙酯馏分能够抑制细胞因子IL-8、TNF和IL-6表达；辣木叶的提取物可以有效的降低关节炎造成的疼痛感，同时，对关节炎的治疗有显著的疗效；经动物实验证明辣木油可加速家兔皮肤创面愈合，缩短愈合时间，减轻组织的病理变化。
红花为活血化瘀的经典中药之一，红花主要含黄酮类物质、脂肪酸、色素、酚酸、挥发油等多种活性成分。其中醌式查尔酮类化合物红花黄色素是其有效成分，是红花发挥药理作用的物质基础。红花及其活性成分可以调控多种与炎症反应相关的生长因子和细胞黏附分子的基因表达。
川芎为中医常用活血化瘀药，具有活血行气、祛风止痛的功效。研究表明，川芎水煎剂能够抑制小鼠神经系统的兴奋性，减轻受损神经根的水肿变性、髓鞘脱失等损伤；川芎嗪有钙离子拮抗作用，能够舒张血管，改善机体缺氧状态，降低毛细血管通透性，抑制血小板聚集、降低血液粘度，改善微循环。
迷迭香中含有鼠尾草酸、鼠尾草酚、迷迭香酸、熊果酸、α-蒎烯、樟脑、1,8-桉叶素、莰烯、龙脑等活性成分，具有抗氧化、抗菌、美容、抗肿瘤、消炎、抗心血管疾病等诸多作用。研究表明，鼠尾草酚以及迷迭香精油中的α-蒎烯、樟脑、1,8-桉叶素等具有具有较好的抗菌活性。
丹参中含有丹参素、迷迭香酸、丹参酮等活性成分，具有活血化瘀的功效，研究表明，这些活性成分具有某些共同的化学结构特征，其主要的作用靶标是苯乙醇胺N-甲基转移酶、儿茶酚O-甲基转移酶和单胺氧化酶A。
三七是跌打损伤第一圣药，止血活血化瘀奇药，三七皂苷对血浆凝血因子与血小板聚集性均有抑制作用，具有活血化瘀功能，另外，三七皂苷属于阿片肽样受体激动剂，对化学性和热刺激性引起的疼痛均具有明显的镇痛作用。
独活具有祛风除湿，通痹止痛之功效，研究表明，其挥发油性成分具有抗炎、镇痛的功效。
香叶天竺葵的主要成分是精油，其中含有香叶醇、芳樟醇和香茅醇等，研究表明，香叶天竺葵精油对致病性和非致病性细菌均具有光谱杀菌和抑菌作用，且香叶醇能够增加皮肤吸收药物的能力，大大提高药物透皮给药能力。
路路通是枫香树的干燥成熟果序，研究表明，其挥发油成分具有明显的抗菌活性，而路路通酸具有一定的抗炎镇痛功效。
薄荷中的薄荷醇能够降低细胞内Ca2+-ATP酶的活性，使细胞内Ca2+不能泵出胞外而间接地增加了细胞内Ca2+的浓度，使肌动蛋白丝收缩，使细胞间隙增加，皮肤的通透性增加。
凤仙花叶含黄酮、萘醌、香豆素、有机酸、花青素和甾醇类等化学成分，研究表明，其中甲花醌和2-甲氧基-1,4萘醌具有较好的抗细菌和抗真菌活性。
薄荷脑外用可以消炎、止痛、止痒、促进血液循环、减轻浮肿等，另外，薄荷脑是一种很好的促渗剂，在多种溶媒系统中均具有较好的促进药物经皮吸收的能力。
本发明以以上原料开发一种复方植物精华提取物的组合物，该组合物涂抹于关节、肌肉或肩颈酸痛处能够活血祛瘀，有效缓解酸痛。
发明内容
本发明的目的在于提供一种复方植物精华提取物的组合物，本发明同时提供其制备方法，该复方植物精华提取物的组合物中的各种成分合理组方、配合共用，通过多种途径、多层次达到活血祛瘀，缓解关节、肌肉、肩颈酸痛的作用。
本发明所述的复方植物精华提取物的组合物由翼籽辣木籽提取物0.5-15份、红花提取物1-12份、川芎提取物1-12份、迷迭香花提取物1-12份、丹参提取物0-18份、三七根提取物1-12份、独活提取物1-12份、香叶天竺葵花油1-40份、路路通提取物1-12份、辣薄荷提取物1-8份、凤仙花叶提取物1-12份、薄荷脑0.01-0.1份制成。
优选地，复方植物精华提取物的组合物各原料的重量配比为翼籽辣木籽提取物1-12份、红花提取物2-10份、川芎提取物2-9份、迷迭香花提取物1.5-9份、丹参提取物3-15份、三七根提取物2-9份、独活提取物2-9份、香叶天竺葵花油3-30份、路路通提取物2-10份、辣薄荷提取物2-6份、凤仙花叶提取物1.5-9份、薄荷脑0.02-0.08份。
更为优选地，复方植物精华提取物的组合物各原料重量配比为：翼籽辣木籽提取物6份、红花提取物6份、川芎提取物5.5份、迷迭香花提取物7份、丹参提取物10份、三七根提取物5份、独活提取物5份、香叶天竺葵花油12份、路路通提取物7份、薄荷提取物4份、凤仙花叶提取物6份、薄荷脑0.06份。
本发明所述的复方植物精华提取物的组合物的制备方法为：
(1)挑选并称取颗粒饱满的翼籽辣木籽，放入超临界萃取罐，升温至萃取罐内温度达到35-50℃，通入二氧化碳气体，设定萃取压力为15-25MPa，静态萃取2小时，获得翼籽辣木籽提取物，以超纯水调节至每毫升提取物相当于10g翼籽辣木籽；
(2)称取干燥的红花药材，置于圆底烧瓶中，加入药材量5-7倍的乙醇溶液(70％)，加热回流提取2-3次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后浓缩得红花提取物(每毫升提取物相当于10g药材)；
(3)称取干燥的川芎药材，粉碎成20目后，置于圆底烧瓶中，加入药材量5-7倍的乙醇溶液(55％)，加热回流提取2-3次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后浓缩得川芎提取物(每毫升提取物相当于10g药材)；
(4)称取干燥的迷迭香花，置于圆底烧瓶中，加入药材量7-10倍的乙醇溶液(55％)，加热回流提取2-3次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后浓缩得迷迭香花提取物(每毫升提取物相当于10g药材)；
(5)称取干燥的丹参药材饮片，粉碎成20目后，置于圆底烧瓶中，加入药材量3-6倍的乙醇溶液(95％)，加热回流提取2-3次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后低温(不超过55℃)减压浓缩得丹参提取物(每毫升提取物相当于10g药材)；
(6)称取干燥的三七根药材，粉碎成20目后，置于圆底烧瓶中，加入药材量3-6倍的乙醇溶液(70％)，加热回流提取2-3次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后减压浓缩得三七根提取物(每毫升提取物相当于10g药材)；
(7)称取干燥的独活药材饮片，粉碎成20目后，置于圆底烧瓶中，加入药材量3-6倍的乙醇溶液(95％)，加热回流提取2-3次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后低温(不超过55℃)减压浓缩得独活提取物(每毫升提取物相当于10g药材)；
(8)取香叶天竺葵花，装入圆底烧瓶中，加入5-10倍超纯水，连接好提取蒸馏装置，加热煮沸，通过冷凝管收集馏出成分，馏出成分再经二次蒸馏获得馏分，馏分经油水分离器处理得油相和水相；水相再用乙醚萃取，收集上层有机相，用无水氯化钙干燥脱水，经水浴除去乙醚，与油相合并得香叶天竺葵花油，以乙醇调节至每毫升提取物相当于10g香叶天竺葵花；
(9)称取干燥的路路通药材，经粗粉碎后置于圆底烧瓶中，加入药材量7-10倍的乙醇溶液(60％)，加热回流提取2-3次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后浓缩得路路通提取物(每毫升提取物相当于10g药材)；
(10)称取干燥的辣薄荷药材，粗粉碎后置于圆底烧瓶中，加入药材量5-8倍的乙醇溶液(70％)，加热回流提取2-3次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后减压浓缩得薄荷提取物(每毫升提取物相当于10g药材)；
(11)称取干燥的凤仙花叶片，粗粉碎后置于圆底烧瓶中，加入药材量5-8倍的乙醇溶液(70％)，加热回流提取2-3次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后减压浓缩得薄荷提取物(每毫升提取物相当于10g药材)；
(12)上述各提取物合并，加入配方量的薄荷脑，充分搅拌使其溶解并混合均匀，4-10℃冷藏保存12-16小时后，经2um有机膜过滤后分装即得复方植物精华提取物的组合物。
本发明的显著优点在于：
(1)针对不同的原料选择不同的提取工艺，能够尽量保留药材有效成分；
(2)提取液中富含黄酮、皂苷等活性成分，在发挥其抗炎止痛功能的同时，还具有很好的抗氧化活性，对其他活性成分起到很好的保护作用；
(3)通过超临界提取法获得的翼籽辣木籽提取物具有很好的皮肤渗透性和化学稳定性，能够促进其他活性成分的透皮吸收，作为天然的防腐剂对组合物起到很好的保护作用。
下面通过具体的实施例对本发明作进一步说明。
具体实施方式
下面结合实施例对本发明作进一步阐述,以下实施方式只以举例的方式描述本发明。很明显,本领域普通技术人员可在本发明的范围和实质内，对本发明进行各种变通和修改。需要了解的是,本发明意欲涵盖在所附权利要求书中包括的变通和修改。
实施例1：
一种复方植物精华提取物的组合物，由以下原料制成：翼籽辣木籽提取物1份、红花提取物2份、川芎提取物2份、迷迭香花提取物1.5份、丹参提取物3份、三七根提取物2份、独活提取物2份、香叶天竺葵花油3份、路路通提取物2份、辣薄荷提取物2份、凤仙花叶提取物1.5份、薄荷脑0.02份。
该复方植物精华提取物的组合物的制备方法为：
(1)挑选并称取颗粒饱满的翼籽辣木籽，放入超临界萃取罐，升温至萃取罐内温度达到50℃，通入二氧化碳气体，设定萃取压力为25MPa，静态萃取2小时，获得翼籽辣木籽提取物，以超纯水调节至每毫升提取物相当于10g翼籽辣木籽；
(2)称取干燥的红花药材，置于圆底烧瓶中，加入药材量7倍的乙醇溶液(70％)，加热回流提取3次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后浓缩得红花提取物(每毫升提取物相当于10g药材)；
(3)称取干燥的川芎药材，粉碎成20目后，置于圆底烧瓶中，加入药材量7倍的乙醇溶液(55％)，加热回流提取3次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后浓缩得川芎提取物(每毫升提取物相当于10g药材)；
(4)称取干燥的迷迭香花，置于圆底烧瓶中，加入药材量10倍的乙醇溶液(55％)，加热回流提取3次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后浓缩得迷迭香花提取物(每毫升提取物相当于10g药材)；
(5)称取干燥的丹参药材饮片，粉碎成20目后，置于圆底烧瓶中，加入药材量6倍的乙醇溶液(95％)，加热回流提取3次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后低温(不超过55℃)减压浓缩得丹参提取物(每毫升提取物相当于10g药材)；
(6)称取干燥的三七根药材，粉碎成20目后，置于圆底烧瓶中，加入药材量6倍的乙醇溶液(70％)，加热回流提取3次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后减压浓缩得三七根提取物(每毫升提取物相当于10g药材)；
(7)称取干燥的独活药材饮片，粉碎成20目后，置于圆底烧瓶中，加入药材量6倍的乙醇溶液(95％)，加热回流提取3次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后低温(不超过55℃)减压浓缩得独活提取物(每毫升提取物相当于10g药材)；
(8)取香叶天竺葵花，装入圆底烧瓶中，加入10倍超纯水，连接好提取蒸馏装置，加热煮沸，通过冷凝管收集馏出成分，馏出成分再经二次蒸馏获得馏分，馏分经油水分离器处理得油相和水相；水相再用乙醚萃取，收集上层有机相，用无水氯化钙干燥脱水，经水浴除去乙醚，与油相合并得香叶天竺葵花油，以乙醇调节至每毫升提取物相当于10g香叶天竺葵花；
(9)称取干燥的路路通药材，经粗粉碎后置于圆底烧瓶中，加入药材量10倍的乙醇溶液(60％)，加热回流提取3次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后浓缩得路路通提取物(每毫升提取物相当于10g药材)；
(10)称取干燥的辣薄荷药材，粗粉碎后置于圆底烧瓶中，加入药材量8倍的乙醇溶液(70％)，加热回流提取3次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后减压浓缩得薄荷提取物(每毫升提取物相当于10g药材)；
(11)称取干燥的凤仙花叶片，粗粉碎后置于圆底烧瓶中，加入药材量8倍的乙醇溶液(70％)，加热回流提取3次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后减压浓缩得薄荷提取物(每毫升提取物相当于10g药材)；
(12)上述各提取物合并，加入配方量的薄荷脑，充分搅拌使其溶解并混合均匀，10℃冷藏保存16小时后，经2um有机膜过滤后分装即得复方植物精华提取物的组合物。
实施例2：
一种复方植物精华提取物的组合物，由以下原料制成：翼籽辣木籽提取物12份、红花提取物10份、川芎提取物9份、迷迭香花提取物9份、丹参提取物15份、三七根提取物9份、独活提取物9份、香叶天竺葵花油30份、路路通提取物10份、辣薄荷提取物6份、凤仙花叶提取物9份、薄荷脑0.08份。
该复方植物精华提取物的组合物的制备方法为：
(1)挑选并称取颗粒饱满的翼籽辣木籽，放入超临界萃取罐，升温至萃取罐内温度达到35℃，通入二氧化碳气体，设定萃取压力为15MPa，静态萃取2小时，获得翼籽辣木籽提取物，以超纯水调节至每毫升提取物相当于10g翼籽辣木籽；
(2)称取干燥的红花药材，置于圆底烧瓶中，加入药材量5倍的乙醇溶液(70％)，加热回流提取2次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后浓缩得红花提取物(每毫升提取物相当于10g药材)；
(3)称取干燥的川芎药材，粉碎成20目后，置于圆底烧瓶中，加入药材量5倍的乙醇溶液(55％)，加热回流提取2次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后浓缩得川芎提取物(每毫升提取物相当于10g药材)；
(4)称取干燥的迷迭香花，置于圆底烧瓶中，加入药材量7倍的乙醇溶液(55％)，加热回流提取2次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后浓缩得迷迭香花提取物(每毫升提取物相当于10g药材)；
(5)称取干燥的丹参药材饮片，粉碎成20目后，置于圆底烧瓶中，加入药材量3倍的乙醇溶液(95％)，加热回流提取2次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后低温(不超过55℃)减压浓缩得丹参提取物(每毫升提取物相当于10g药材)；
(6)称取干燥的三七根药材，粉碎成20目后，置于圆底烧瓶中，加入药材量3倍的乙醇溶液(70％)，加热回流提取2次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后减压浓缩得三七根提取物(每毫升提取物相当于10g药材)；
(7)称取干燥的独活药材饮片，粉碎成20目后，置于圆底烧瓶中，加入药材量3倍的乙醇溶液(95％)，加热回流提取2次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后低温(不超过55℃)减压浓缩得独活提取物(每毫升提取物相当于10g药材)；
(8)取香叶天竺葵花，装入圆底烧瓶中，加入5倍超纯水，连接好提取蒸馏装置，加热煮沸，通过冷凝管收集馏出成分，馏出成分再经二次蒸馏获得馏分，馏分经油水分离器处理得油相和水相；水相再用乙醚萃取，收集上层有机相，用无水氯化钙干燥脱水，经水浴除去乙醚，与油相合并得香叶天竺葵花油，以乙醇调节至每毫升提取物相当于10g香叶天竺葵花；
(9)称取干燥的路路通药材，经粗粉碎后置于圆底烧瓶中，加入药材量7倍的乙醇溶液(60％)，加热回流提取2次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后浓缩得路路通提取物(每毫升提取物相当于10g药材)；
(10)称取干燥的辣薄荷药材，粗粉碎后置于圆底烧瓶中，加入药材量5倍的乙醇溶液(70％)，加热回流提取2次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后减压浓缩得薄荷提取物(每毫升提取物相当于10g药材)；
(11)称取干燥的凤仙花叶片，粗粉碎后置于圆底烧瓶中，加入药材量5倍的乙醇溶液(70％)，加热回流提取2次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后减压浓缩得薄荷提取物(每毫升提取物相当于10g药材)；
(12)上述各提取物合并，加入配方量的薄荷脑，充分搅拌使其溶解并混合均匀，4℃冷藏保存12小时后，经2um有机膜过滤后分装即得复方植物精华提取物的组合物。
实施例3：
一种复方植物精华提取物的组合物，由以下原料制成：翼籽辣木籽提取物6份、红花提取物6份、川芎提取物5.5份、迷迭香花提取物7份、丹参提取物10份、三七根提取物5份、独活提取物5份、香叶天竺葵花油12份、路路通提取物7份、辣薄荷提取物4份、凤仙花叶提取物6份、薄荷脑0.06份。
该复方植物精华提取物的组合物的制备方法为：
(1)挑选并称取颗粒饱满的翼籽辣木籽，放入超临界萃取罐，升温至萃取罐内温度达到45℃，通入二氧化碳气体，设定萃取压力为20MPa，静态萃取2小时，获得翼籽辣木籽提取物，以超纯水调节至每毫升提取物相当于10g翼籽辣木籽；
(2)称取干燥的红花药材，置于圆底烧瓶中，加入药材量5倍的乙醇溶液(70％)，加热回流提取2次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后浓缩得红花提取物(每毫升提取物相当于10g药材)；
(3)称取干燥的川芎药材，粉碎成20目后，置于圆底烧瓶中，加入药材量5倍的乙醇溶液(55％)，加热回流提取2次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后浓缩得川芎提取物(每毫升提取物相当于10g药材)；
(4)称取干燥的迷迭香花，置于圆底烧瓶中，加入药材量7倍的乙醇溶液(55％)，加热回流提取2次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后浓缩得迷迭香花提取物(每毫升提取物相当于10g药材)；
(5)称取干燥的丹参药材饮片，粉碎成20目后，置于圆底烧瓶中，加入药材量3倍的乙醇溶液(95％)，加热回流提取2次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后低温(不超过55℃)减压浓缩得丹参提取物(每毫升提取物相当于10g药材)；
(6)称取干燥的三七根药材，粉碎成20目后，置于圆底烧瓶中，加入药材量3倍的乙醇溶液(70％)，加热回流提取2次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后减压浓缩得三七根提取物(每毫升提取物相当于10g药材)；
(7)称取干燥的独活药材饮片，粉碎成20目后，置于圆底烧瓶中，加入药材量3倍的乙醇溶液(95％)，加热回流提取2次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后低温(不超过55℃)减压浓缩得独活提取物(每毫升提取物相当于10g药材)；
(8)取香叶天竺葵花，装入圆底烧瓶中，加入5倍超纯水，连接好提取蒸馏装置，加热煮沸，通过冷凝管收集馏出成分，馏出成分再经二次蒸馏获得馏分，馏分经油水分离器处理得油相和水相；水相再用乙醚萃取，收集上层有机相，用无水氯化钙干燥脱水，经水浴除去乙醚，与油相合并得香叶天竺葵花油，以乙醇调节至每毫升提取物相当于10g香叶天竺葵花；
(9)称取干燥的路路通药材，经粗粉碎后置于圆底烧瓶中，加入药材量7倍的乙醇溶液(60％)，加热回流提取2次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后浓缩得路路通提取物(每毫升提取物相当于10g药材)；
(10)称取干燥的辣薄荷药材，粗粉碎后置于圆底烧瓶中，加入药材量5倍的乙醇溶液(70％)，加热回流提取2次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后减压浓缩得薄荷提取物(每毫升提取物相当于10g药材)；
(11)称取干燥的凤仙花叶片，粗粉碎后置于圆底烧瓶中，加入药材量5倍的乙醇溶液(70％)，加热回流提取2次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后减压浓缩得薄荷提取物(每毫升提取物相当于10g药材)；
(12)上述各提取物合并，加入配方量的薄荷脑，充分搅拌使其溶解并混合均匀，4℃冷藏保存12小时后，经2um有机膜过滤后分装即得复方植物精华提取物的组合物。
以上实施例中，所得复方植物精华提取物的组合物可与一定的药用辅料或其他化妆品用原辅料经常规工艺制成药油、搽剂、酊剂、软膏剂、气雾剂等剂型的外用药品或护肤类化妆品。
Claims (6)
1.一种复方植物精华提取物的组合物，其特征在于：该复方植物精华提取物的组合物由翼籽辣木籽提取物0.5-15份、红花提取物1-12份、川芎提取物1-12份、迷迭香花提取物1-12份、丹参提取物0-18份、三七根提取物1-12份、独活提取物1-12份、香叶天竺葵花油1-40份、路路通提取物1-12份、辣薄荷提取物1-8份、凤仙花叶提取物1-12份、薄荷脑0.01-0.1份制成。
2.根据权利要求1所述的复方植物精华提取物的组合物，其特征在于：所述的复方植物精华提取物的组合物各原料的重量配比为翼籽辣木籽提取物1-12份、红花提取物2-10份、川芎提取物2-9份、迷迭香花提取物1.5-9份、丹参提取物3-15份、三七根提取物2-9份、独活提取物2-9份、香叶天竺葵花油3-30份、路路通提取物2-10份、辣薄荷提取物2-6份、凤仙花叶提取物1.5-9份、薄荷脑0.02-0.08份。
3.根据权利要求1所述的复方植物精华提取物的组合物，其特征在于：原料重量配比为：翼籽辣木籽提取物6份、红花提取物6份、川芎提取物5.5份、迷迭香花提取物7份、丹参提取物10份、三七根提取物5份、独活提取物5份、香叶天竺葵花油12份、路路通提取物7份、辣薄荷提取物4份、凤仙花叶提取物6份、薄荷脑0.06份。
4.根据权利要求1-3任一所述的复方植物精华提取物的组合物制备方法，其特征在于：工艺步骤包括：
(1)挑选并称取颗粒饱满的翼籽辣木籽，放入超临界萃取罐，升温至萃取罐内温度达到35-50℃，通入二氧化碳气体，设定萃取压力为15-25MPa，静态萃取2小时，获得翼籽辣木籽提取物，以超纯水调节至每毫升提取物相当于10g翼籽辣木籽；
(2)称取干燥的红花药材，置于圆底烧瓶中，加入药材量5-7倍的乙醇溶液(70％)，加热回流提取2-3次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后浓缩得红花提取物(每毫升提取物相当于10g药材)；
(3)称取干燥的川芎药材，粉碎成20目后，置于圆底烧瓶中，加入药材量5-7倍的乙醇溶液(55％)，加热回流提取2-3次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后浓缩得川芎提取物(每毫升提取物相当于10g药材)；
(4)称取干燥的迷迭香花，置于圆底烧瓶中，加入药材量7-10倍的乙醇溶液(55％)，加热回流提取2-3次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后浓缩得迷迭香花提取物(每毫升提取物相当于10g药材)；
(5)称取干燥的丹参药材饮片，粉碎成20目后，置于圆底烧瓶中，加入药材量3-6倍的乙醇溶液(95％)，加热回流提取2-3次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后低温(不超过55℃)减压浓缩得丹参提取物(每毫升提取物相当于10g药材)；
(6)称取干燥的三七根药材，粉碎成20目后，置于圆底烧瓶中，加入药材量3-6倍的乙醇溶液(70％)，加热回流提取2-3次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后减压浓缩得三七根提取物(每毫升提取物相当于10g药材)；
(7)称取干燥的独活药材饮片，粉碎成20目后，置于圆底烧瓶中，加入药材量3-6倍的乙醇溶液(95％)，加热回流提取2-3次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后低温(不超过55℃)减压浓缩得独活提取物(每毫升提取物相当于10g药材)；
(8)取香叶天竺葵花，装入圆底烧瓶中，加入5-10倍超纯水，连接好提取蒸馏装置，加热煮沸，通过冷凝管收集馏出成分，馏出成分再经二次蒸馏获得馏分，馏分经油水分离器处理得油相和水相；水相再用乙醚萃取，收集上层有机相，用无水氯化钙干燥脱水，经水浴除去乙醚，与油相合并得香叶天竺葵花油，以乙醇调节至每毫升提取物相当于10g香叶天竺葵花；
(9)称取干燥的路路通药材，经粗粉碎后置于圆底烧瓶中，加入药材量7-10倍的乙醇溶液(60％)，加热回流提取2-3次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后浓缩得路路通提取物(每毫升提取物相当于10g药材)；
(10)称取干燥的辣薄荷药材，粗粉碎后置于圆底烧瓶中，加入药材量5-8倍的乙醇溶液(70％)，加热回流提取2-3次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后减压浓缩得薄荷提取物(每毫升提取物相当于10g药材)；
(11)称取干燥的凤仙花叶片，粗粉碎后置于圆底烧瓶中，加入药材量5-8倍的乙醇溶液(70％)，加热回流提取2-3次，每次提取时间为1.5小时，提取液过滤，减压回收乙醇后减压浓缩得薄荷提取物(每毫升提取物相当于10g药材)；
(12)上述各提取物合并，加入配方量的薄荷脑，充分搅拌使其溶解并混合均匀，4-10℃冷藏保存12-16小时后，经2um有机膜过滤后分装即得复方植物精华提取物的组合物。
5.根据权利要求4所述的复方植物精华提取物的组合物制备方法，其特征在于：所述的复方植物精华提取物的组合物可与一定的药用辅料或其他化妆品用原辅料经一定工艺制成药油、搽剂、酊剂、软膏剂、气雾剂等剂型的外用药品、消毒用品或护肤类化妆品。
6.根据权利要求4所述的复方植物精华提取物的组合物制备方法，其特征在于：所述的复方植物精华提取物的组合物可与一定的药用辅料或其他化妆品用原辅料经一定工艺制成止痒水、风湿油、止痛精油、消肿止痛气雾剂等产品。
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