CN108451878A - A kind of antiallergic sense toothpaste - Google Patents
A kind of antiallergic sense toothpaste Download PDFInfo
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- CN108451878A CN108451878A CN201810613965.6A CN201810613965A CN108451878A CN 108451878 A CN108451878 A CN 108451878A CN 201810613965 A CN201810613965 A CN 201810613965A CN 108451878 A CN108451878 A CN 108451878A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/362—Polycarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
- A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/20—Chemical, physico-chemical or functional or structural properties of the composition as a whole
- A61K2800/28—Rubbing or scrubbing compositions; Peeling or abrasive compositions; Containing exfoliants
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Abstract
The invention discloses a kind of antiallergic sense toothpaste, it is grouped as by the group of following parts by weight:0.4 0.6 portions of cicada sloughs, 26 parts of myrrhs, 5 10 parts of azalaic acids, 46 parts of foaming agents, 35 parts of thickeners, 28 32 parts of deionized waters, 0.4 0.6 parts of sweeteners, 5 10 portions of feverfews, 13 parts of frankincenses, 8 12 parts of rubbing agents, 0.4 0.6 parts of carbomers, 13 parts of chamomiles, 10 14 parts of moisturizer.After the toothpaste use of the present invention, tooth is substantially reduced hot and cold, sour susceptibility;In toothpaste component, since azalaic acid, feverfew, frankincense and myrrh to be combined in proportion, for preventing saprodontia from having a significant effect, and body is not damaged during use.
Description
Technical field
The present invention relates to a kind of oral-cavity articles, and in particular to a kind of antiallergic sense toothpaste.
Background technology
Saprodontia(dental caries)It is a kind of disease that hard tooth tissue is gradually destroyed.Morbidity starts in corona, such as
It is not treated in time, lesion continues to develop, and forms cavity, destroys disappearance completely to corona eventually.The cavity of untreated is will not be certainly
Row healing, the final result of development is loss of tooth.Saprodontia is the common frequently-occurring disease of children, and Primary Caries rate peak about exists
5 years old or so, permanent teeth caries prevalence rate was about at 15 years old or so.According to the investigation of Shanghai City 1981 material, in 15059 Children in Kindergartens and
Primary Caries number is 8523 people in middle and elementary school student, and Primary Caries rate is 56.62%.Caries prevalence rate was up to 65.92%, 9 years old at 4 years old
83.57%.Investigation according to nineteen eighty-three Beijing area to students in middle and primary schools, 7 years old dental caries caries prevalence rate average out to 48.88% of outlying area,
12 years old are 67.29%, and 17 years old is 73.61%.General rural area is low compared with urban population Permanent Teeth dental caries.Data shows urban population permanent teeth
Caries prevalence rate average out to 63.65%, average dental caries tooth number is 1.67;Agricultural population caries prevalence rate is 55.67%, average dental caries tooth number 1.27
.China has a vast territory, and various regions condition is different, and suffering from dental caries situation also has difference.Therefore, preventing decayed tooth work should be from one eruption of tooth just
Start.
Saprodontia is bacteriosis, therefore it can be with secondary pulpitis and periapical inflammation, or even can cause alveolar bone and jaw
Inflammation of bone.The secondary infection of saprodontia can form lesion(focal infection), cause at or add arthritis, heart periostitis,
Chronic renal is and the whole bodies other diseases such as a variety of eye disease.Saprodontia is multi-factor disease, and main includes three aspects:Bacterium, diet,
Tooth and saliva, three is interrelated, and saprodontia cannot all be occurred on one side by lacking.Current scholars think saliva as tooth
External environment is the factor of great influence dental caries.
Bacterium:During saprodontia occurrence and development, since bacterium plays leading role in dental caries morbidity, in recent years
Generally acknowledge that dental caries are that there are many cariogenic bacterial species of bacterial disease in the world, most importantly certain streptococcus mutans and lactic acid bar
Bacterium.These bacteriums in saliva mucoprotein and food scraps mix, be firmly adhered in dental surface and nest ditch.
This binding is called plaque or bacterial plaque(dental plaque).A large amount of bacteriums production acid in bacterial plaque, is caused below bacterial plaque
Enamel surfaces decalcification, dissolving.Clinical investigation proves that the children caries in oral cavity more than bacterial plaque are also more.
Diet:In saprodontia forming process, diet is the important function object of bacterium.Contain a large amount of carbon hydrate in food
Object and sugar, these substances had both supplied bacterium life and movable energy in bacterial plaque, and so that glycolysis is generated further through bacterial metabolism effect
Organic acid, sour prolonged stay make enamel demineralization destroy in dental surface and nest ditch, and followed by certain bacteriums make proteolytic again
Form cavity.There are many cariogenic carbohydrate, most importantly sucrose.Tooth development period, nutrition determine the biochemical knot of dental tissue
Structure, the good tooth anti-caries of calcification are high.If the mineral salts contained in food, main vitamins and trace element, as calcium,
The anti-caries of the deficiencies of phosphorus, vitamin B1, D and fluorine, tooth are just low, the condition for causing saprodontia to fall ill.Deciduous teeth are in foetal period
Occur, development and calcification, the nutrition of female new newborn phase, although reinforcing parent without decisive influence to the developments of fetus deciduous teeth
Nutrition is still advantageous to deciduous teeth calcification.Unless parent suffers from serious metabolic obstacle disease or hereditary disease, general deciduous teeth are not easily susceptible to seriously
It influences.
Tooth:Form, structure and the position of tooth and saprodontia morbidity have apparent relationship.The nest ditch that tooth stings face is development
The defect left in the process is easy retained cells and food scraps in deep nest ditch, and is not easy to dispose, and is easy to induce saprodontia.
Mineralising is insufficient, especially the insufficient tooth of calcification, and the consistency of enamel and dentine is not high, and anti-caries is low, is easy to suffer from saprodontia.Fluorine
It is critically important to the anti-caries for enhancing tooth although the content very pettiness in dental mineralization structure.In tooth just containing appropriate fluorine
It is not susceptible to saprodontia.The structure and calcification degree of deciduous teeth and permanent teeth are all not mature enough, therefore are easy by cariogenic factor
It influences, caries prevalence rate is high.Saliva is the external environment of tooth, play buffering, washing, anti-castor or it is antibacterial the effects that.Amount mostly dilute saliva
Liquid can wash dental surface, reduce bacterium and food scraps accumulation.Amount less and thick saliva is easy to be detained, encourage bacterial plaque formed
On tooth surfaces with adherency.Its buffer capacity of the property and composition influence of saliva also influences the living condition of bacterium.
The appearance of saprodontia in order to prevent generally all uses fluorine-containing toothpaste, and the ingredient of toothpaste is extremely complex, containing a large amount of brilliant
Body grain and chemical synthesis substance, such as foaming agent, rubbing agent, moisturizer, thickener, preservative etc., with regard to solid insoluble
Speech, there is calcium monohydrogen phosphate, a- aluminium hydroxides, silica, carbonate(Calcium, magnesium), talcum powder and inorganic thickening agent etc., it is most of
For chemical composition, wherein rubbing agent selects silica, has containing foaming agent and reactive blowing agent two types, all contains preservative,
Fluoride is added again, achievees the effect that anti-caries such as sodium fluoride or sodium monofluorophosphate, although having certain mothproof effect, fluorine
Element is entered into the human body by oral mucosa, so as to cause fluorine poisoning, less serious case, den tal fluorosis, severe one occurs, it may appear that fluorosis of bone
Etc. diseases.In daily normal diet, the content of the Trace Fluoride of needed by human body is had reached, toothpaste with fluoride is reused, just exceeds
Fluorine content needed for daily.It is automatic to swallow toothpaste when brushing teeth, it accumulates over a long period, toothpaste is easy to draw in their internal accumulation
Lesion is played, therefore there are some potential safety problemss for fluorine-containing toothpaste.
The existing antianaphylactic effect of toothpaste, it is not satisfactory.
Invention content
A kind of preventing decayed teeth and tooth effect that in order to overcome above-mentioned deficiency, present invention aims at providing is good and safe and reliable to be resisted
Sensitive toothpaste.
To achieve the goals above, the technical solution adopted by the present invention is:
A kind of antiallergic sense toothpaste is grouped as by the group of following parts by weight:0.4-0.6 portions of cicada sloughs, 2-6 parts of myrrhs, 5-10 parts of Du
Cuckoo spend acid, 4-6 parts of foaming agents, 3-5 parts of thickeners, 28-32 parts of deionized waters, 0.4-0.6 parts of sweeteners, 5-10 portions of feverfews,
1-3 parts of frankincenses, 8-12 parts of rubbing agents, 0.4-0.6 parts of carbomers, 1-3 parts of chamomiles, 10-14 parts of moisturizer.
Wherein, azalaic acid has inhibition and killing effect to intraoral various aerobic bacterias and anaerobic bacteria;In feverfew
Glucoside containing chrysanthemum, amino acid, flavonoids and multivitamin and trace element;Frankincense is olive subject plant Boswellia carterii, Bao reaches Boswellia carterii,
The oleo-gum-resin of the skin zones such as wild Boswellia carterii exudation, promoting blood circulation and stopping pain;Myrrh is olive subject plant Chinese violet tree or the drying of Ha Didingshu
Resin, removing blood stasis and analgesics, externally used detumescence myogenic, external application are controlled the open sore part and are not restrained long.Carbomer, chamomile and the addition of cicada slough, to tooth
Tooth has good anti-allergic effects.
Further, the frosting agent is silica.
Further, the thickener is sodium carboxymethylcellulose.
Further, the moisturizer is sorbierite.
Further, the sweetener is the stevioside that essence carries from STEVIA REBAUDIANA.
Further, the foaming agent is sodium lauroyl sarcosine.
Further, the toothpaste is grouped as by the group of following parts by weight:12 parts of moisturizer, 10 parts of rubbing agents,
0.5 part of sweetener, 5 parts of foaming agents, 4 parts of thickeners, 30 parts of deionized waters, 7.5 parts of azalaic acids, 7.5 portions of feverfews, 2 parts of breasts
Perfume, 4 parts of myrrhs, 0.5 part of carbomer, 2 parts of chamomiles, 0.5 portion of cicada slough.
The preparation method of this patent toothpaste, includes the following steps:A, respectively by feverfew, frankincense and myrrh carry out drying and
It crushes;B, feverfew, frankincense and the myrrh after azalaic acid, deionized water and crushing are weighed in proportion, are put into stirred tank;
C, it is mixed, is uniformly dispersed with 900-1200r/min, the temperature control in stirred tank is in 44-60 DEG C, mixing time
120-140min obtains stirring mixture;D, remaining raw material is added in above-mentioned stirred tank in proportion again, with 2000-
2400r/min is mixed, mixing time 10-20min;E, vacuum item of the mixture in 0.06-0.08MPa will be stirred
It under part, is stirred, until at paste to get toothpaste.
Beneficial effects of the present invention:After the toothpaste use of this patent, tooth is substantially reduced hot and cold, sour susceptibility;
It is bright for preventing saprodontia to have since azalaic acid, feverfew, frankincense and myrrh to be combined in proportion in toothpaste component
Aobvious effect, and body is not damaged during use.
Specific implementation mode
Embodiment 1:A kind of antiallergic sense toothpaste is grouped as by the group of following parts by weight:12 parts of moisturizer, 10 parts of frictions
Agent, 0.5 part of sweetener, 5 parts of foaming agents, 4 parts of thickeners, 30 parts of deionized waters, 7.5 parts of azalaic acids, 7.5 portions of feverfews, 2 parts
Frankincense, 4 parts of myrrhs, 0.4 part of carbomer, 1 part of chamomile, 0.4 portion of cicada slough.The frosting agent is silica, the increasing
Thick dose is sodium carboxymethylcellulose, and the moisturizer is sorbierite.In proportion by azalaic acid, feverfew, frankincense and myrrh
It is combined, it is automatic to swallow toothpaste to preventing tooth erosion from having a significant effect, and when brushing teeth, it accumulates over a long period,
Toothpaste will not cause lesion in their internal accumulation, not damaged to body.
0.4 part of carbomer, 1 part of chamomile and 0.4 portion of cicada slough are added, and have good anti-allergic effects to tooth.
Experiment on probation is carried out to toothpaste obtained above, experimental result statistics is as follows:
100 6-15 Sui children to be extracted, and each children is allowed to eat sweet food daily, the time for trying out this patent toothpaste is 1 year,
Early, middle and late to be brushed teeth three times with toothpaste, it is 100 not have the number of dental caries after on probation, it is seen then that toothpaste has intraoral bacterium
Have inhibition and killing effect, eat sweet food daily, using this patent toothpaste also nobody there are dental caries;
100 adults for having odonthemodia are extracted, the time for trying out this patent toothpaste is 3 days, early, middle and late to brush teeth three with toothpaste
Secondary, backteeth on probation is 92 people to the number that hot and cold, sour susceptibility is substantially reduced, and tries out backteeth to hot and cold, sour susceptibility
It is 8 people to change little number.
Embodiment 2:A kind of antiallergic sense toothpaste is grouped as by the group of following parts by weight:10 parts of moisturizer, 8 parts of rubbing agents,
0.4 part of sweetener, 4 parts of foaming agents, 3 parts of thickeners, 28 parts of deionized waters, 5 parts of azalaic acids, 5 portions of feverfews, 1 part of frankincense, 2
Part myrrh, 0.5 part of carbomer, 2 parts of chamomiles, 0.5 portion of cicada slough.The frosting agent is silica, and the thickener is
Sodium carboxymethylcellulose, the moisturizer are sorbierites.Azalaic acid, feverfew, frankincense and myrrh are subjected to group in proportion
It closes, it is automatic to swallow toothpaste to preventing tooth erosion from having a significant effect, and when brushing teeth, it accumulates over a long period, toothpaste exists
Their internal accumulation, will not cause lesion, not damaged to body.
Experiment on probation is carried out to toothpaste obtained above, experimental result statistics is as follows:
100 6-15 Sui children to be extracted, and each children is allowed to eat sweet food daily, the time for trying out this patent toothpaste is 1 year,
Early, middle and late to be brushed teeth three times with toothpaste, it is 100 not have the number of dental caries after on probation, it is seen then that toothpaste has intraoral bacterium
Have inhibition and killing effect, eat sweet food daily, using this patent toothpaste also nobody there are dental caries;
100 adults for having odonthemodia are extracted, the time for trying out this patent toothpaste is 3 days, early, middle and late to brush teeth three with toothpaste
Secondary, backteeth on probation is 96 people to the number that hot and cold, sour susceptibility is substantially reduced, and tries out backteeth to hot and cold, sour susceptibility
It is 4 people to change little number.
Embodiment 3:A kind of antiallergic sense toothpaste is grouped as by the group of following parts by weight:14 parts of moisturizer, 12 parts of rubbing agents, 0.6
Part sweetener, 6 parts of foaming agents, 5 parts of thickeners, 32 parts of deionized waters, 10 parts of azalaic acids, 10 portions of feverfews, 3 parts of frankincenses, 6 parts
Myrrh, 0.6 part of carbomer, 3 parts of chamomiles, 0.6 portion of cicada slough.The frosting agent is silica, and the thickener is carboxylic
Sodium carboxymethylcellulose pyce, the moisturizer are sorbierites.Azalaic acid, feverfew, frankincense and myrrh are combined in proportion,
It is automatic to swallow toothpaste to preventing tooth erosion from having a significant effect, and when brushing teeth, it accumulates over a long period, toothpaste is at him
Internal accumulation, lesion will not be caused, body is not damaged.
The toothpaste preparation method includes the following steps:A, feverfew, frankincense and myrrh are dried and is crushed respectively;B、
Feverfew, frankincense and the myrrh after azalaic acid, deionized water and crushing are weighed in proportion, are put into stirred tank;C, with
1200r/min is mixed, and is uniformly dispersed, and the temperature in stirred tank is controlled at 60 DEG C, and mixing time 140min must be stirred
Mix mixture;D, remaining raw material is added in above-mentioned stirred tank in proportion again, is mixed with 2400r/min,
Mixing time is 20min;E, will stirring mixture under the vacuum condition of 0.08MPa, be stirred, until at paste to get
Toothpaste.
Experiment on probation is carried out to toothpaste obtained above, experimental result statistics is as follows:
100 6-15 Sui children to be extracted, and each children is allowed to eat sweet food daily, the time for trying out this patent toothpaste is 1 year,
Early, middle and late to be brushed teeth three times with toothpaste, it is 100 not have the number of dental caries after on probation, it is seen then that toothpaste has intraoral bacterium
Have inhibition and killing effect, eat sweet food daily, using this patent toothpaste also nobody there are dental caries;
100 adults for having odonthemodia are extracted, the time for trying out this patent toothpaste is 3 days, early, middle and late to brush teeth three with toothpaste
Secondary, backteeth on probation is 94 people to the number that hot and cold, sour susceptibility is substantially reduced, and tries out backteeth to hot and cold, sour susceptibility
It is 6 people to change little number.
Claims (7)
1. a kind of antiallergic sense toothpaste, which is characterized in that it is grouped as by the group of following parts by weight:0.4-0.6 parts of cicada sloughs, 2-6
Part myrrh, 5-10 parts of azalaic acids, 4-6 parts of foaming agents, 3-5 parts of thickeners, 28-32 parts of deionized waters, 0.4-0.6 parts of sweet tastes
Agent, 5-10 portions of feverfews, 1-3 parts of frankincenses, 8-12 parts of rubbing agents, 0.4-0.6 parts of carbomers, 1-3 parts of chamomiles, 10-14 parts of guarantors
Humectant.
2. antiallergic sense toothpaste according to claim 1, it is characterised in that:The toothpaste is by the group of following parts by weight
It is grouped as:12 parts of moisturizer, 10 parts of rubbing agents, 0.5 part of sweetener, 5 parts of foaming agents, 4 parts of thickeners, 30 parts of deionized waters, 7.5
Part azalaic acid, 7.5 portions of feverfews, 2 parts of frankincenses, 4 parts of myrrhs, 0.5 part of carbomer, 2 parts of chamomiles, 0.5 portion of cicada slough.
3. antiallergic sense toothpaste according to claim 1, it is characterised in that:The frosting agent is silica.
4. antiallergic sense toothpaste according to claim 1, it is characterised in that:The thickener is sodium carboxymethylcellulose.
5. antiallergic sense toothpaste according to claim 1, it is characterised in that:The moisturizer is sorbierite.
6. antiallergic sense toothpaste according to claim 1, it is characterised in that:Sweetener essence from STEVIA REBAUDIANA carries
Stevioside.
7. antiallergic sense toothpaste according to claim 1, it is characterised in that:The foaming agent is sodium lauroyl sarcosine.
Priority Applications (1)
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CN201810613965.6A CN108451878A (en) | 2018-06-14 | 2018-06-14 | A kind of antiallergic sense toothpaste |
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CN201810613965.6A CN108451878A (en) | 2018-06-14 | 2018-06-14 | A kind of antiallergic sense toothpaste |
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CN108451878A true CN108451878A (en) | 2018-08-28 |
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CN201810613965.6A Withdrawn CN108451878A (en) | 2018-06-14 | 2018-06-14 | A kind of antiallergic sense toothpaste |
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