CN105687083A - Mouthwash having bacteriostatic and bleeding stopping effects and preparation method of mouthwash - Google Patents

Mouthwash having bacteriostatic and bleeding stopping effects and preparation method of mouthwash Download PDF

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CN105687083A
CN105687083A CN201610130506.3A CN201610130506A CN105687083A CN 105687083 A CN105687083 A CN 105687083A CN 201610130506 A CN201610130506 A CN 201610130506A CN 105687083 A CN105687083 A CN 105687083A
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mouthwash
collutory
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folium
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杨风英
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/35—Caprifoliaceae (Honeysuckle family)
    • A61K36/355—Lonicera (honeysuckle)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/534—Mentha (mint)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/82—Theaceae (Tea family), e.g. camellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
    • A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/98—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin
    • A61K8/987—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution of animal origin of species other than mammals or birds
    • A61K8/988—Honey; Royal jelly, Propolis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses

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Abstract

The invention discloses mouthwash having bacteriostatic and bleeding stopping effects and a preparation method of the mouthwash. The mouthwash is prepared from raw materials in parts by weight as follows: 0.5-1 part of active calcium powder, 0.1-2 parts of a honeysuckle flower extract, 0.1-1.5 parts of propolis, 0.2-0.5 parts of paeonol, 0.1-2 parts of deep sea salt, 0.1-0.5 parts of a peppermint extract, 0.5-3 parts of stevioside, 0.5-1 part of loquat leaves, 0.1-0.3 parts of eucalyptus oil, 2-3 parts of an oil tea solution and 90-95 parts of purified water. Old tea is added to the mouthwash, contains abundant acid and can stop bleeding of blood capillaries. The mouthwash has obvious treatment effects on stomatitis, glossanthrax, eczema, gingival bleeding and the like.

Description

A kind of antibacterial hemostasis collutory and preparation method thereof
Technical field
The invention belongs to oral nursing liquid technical field, be specifically related to a kind of antibacterial hemostasis collutory and preparation method thereof。
Background technology
Along with the development of society, the raising of living standards of the people, the dietary habit of people there occurs significant change, and oral disease is following, has a strong impact on the quality of the life of people。Dental problems is the modal disease of oral disease, and radical cure difficulty is big, affects daily life。Modal odontopathy is exactly dental caries, pulpitis and periapical periodontitis clinically, latter two disease is typically all and is developed without in time treatment by dental caries, also having relatively conventional odontopathy is periodontal disease and gingivitis, both belongs to disease of the oral soft tissues, wherein the prevalence of periodontitis is significantly high, treat complex, and more after not good, serious periodontitis can cause denture loose or dislocation。For a long time, the treatment of oral disease being adopted chemistry, antibiotics mostly, although playing a role at that time, but along with the Reusability of medicine, bringing a series of adverse effect, for instance: develop immunity to drugs bacterial strain, the toxic and side effects to human body。In recent years, enzyme was also used to the treatment of oral disease, but a kind of enzyme can only act on one or a class material, and the effect of enzyme needs suitable temperature and pH, has significant limitation。
Chinese patent 201410425062.7 discloses a kind of collutory containing enzyme Yu Pericarpium Citri Reticulatae extract, it is made up of Pericarpium Citri Reticulatae extract, alpha-glucanase, 1,4 beta-glucanase, α-amylase, Folium Menthae extract, Sal and water, it comprises two kinds of enzymes, need to keep the activity of enzyme during storage, optimum temperature range 50～55 DEG C and the optimum pH scope 6.0～6.5 of enzyme during use, can not be reached。For solving the defect that above-mentioned patent exists, Chinese patent 201510078397.0 discloses the antibacterial collutory of activated calcium, is made up of activated calcium powder, Flos Lonicerae extract, propolis, paeonol, Sal, Folium Menthae extract, stevioside and pure water。This collutory is applied widely, easy to use, has the effect of cleaning, antibacterial, anti-caries and fresh breath, without any side effects；Meanwhile, it is capable to promote the calcification of tooth, prevent and treat gingival hemorrhage。But owing to this collutory can prevent gingival hemorrhage, and to gingival hemorrhage without obvious curative effects。
Summary of the invention
It is an object of the invention to: provide one to have prevention gingival hemorrhage, and for gingival hemorrhage collutory with anastalsis and preparation method thereof。
To achieve these goals, the present invention adopts the following technical scheme that
A kind of antibacterial hemostasis collutory, it is characterised in that: this collutory is made up of the raw material of following weight: activated calcium powder 0.5～1 part, Flos Lonicerae extract 0.1～2 part, propolis 0.1～1.5 part, paeonol 0.2～0.5 part, deep sea salt 0.1～2 part, Folium Menthae extract 0.1～0.5 part, stevioside 0.5～3 part, Folium Eriobotryae 0.5～1 part, Eucalyptus oil 0.1～0.3 part, old tea liquid 2～3 parts, pure water 90～95 parts。
As preferably, the antibacterial hemostasis collutory of described one, it is characterised in that: this collutory is made up of the raw material of following weight: activated calcium powder 0.8 part, Flos Lonicerae extract 1.2 parts, propolis 0.9 part, paeonol 0.3 part, deep sea salt 1 part, Folium Menthae extract 0.3 part, stevioside 1.8 parts, Folium Eriobotryae 0.8 part, Eucalyptus oil 0.2 part, old tea liquid 2.5 parts, pure water 92 parts。
Further, described old tea liquid refers to the soaked placement tea of 15～18 hours of Folium Camelliae sinensis, and it is after high temperature sterilize processes, standby。
Further, the preparation technology of described activated calcium powder is: chooses marine organisms Concha Ostreae and removes impurity, dries 1 hour for 100 DEG C, after preliminary pulverizing, calcines 3～8 hours, obtain the superfine active calcium powder that particle diameter is 1～100 μm under 900～1000 DEG C of hot conditionss。
Further, the preparation technology of described Flos Lonicerae extract is: 1) mark 1:8～10 weigh new fresh honeysuckle and pure water by weight；2) Flos Lonicerae is immersed water in 80 DEG C of pure water and carry 1.5 hours；3) repeat step 1), 2) twice, it is that after 1.12～1.14,60 DEG C of vacuum dryings, gained powder is Flos Lonicerae extract that gained solution decompression is concentrated into after filtration concentrated solution relative density。
Further, the preparation technology of described Folium Menthae extract is: 1) score ratio 1:10～20 weigh mentha leave and petroleum ether by weight；2) mentha leave is immersed soaking at room temperature 3 hours in petroleum ether；3) repeat step 1), 2) three times, after filtration, extracting solution is merged, uses Rotary Evaporators steaming petroleum ether, obtain Folium Menthae extract with anhydrous sodium sulfate dehydration。
The preparation method of described antibacterial hemostasis collutory is: 1) weigh raw material according to said ratio；2), after each raw material weighed being mixed, stir；3) heating is to 50～60 DEG C, and is incubated 1～2 hour, then stands to room temperature；4) ultrasonic disperse is after 5～10 minutes, sterile filling。
Using method: diet or use after smoking, discharge best results after collutory being kept in the mouth 5～7 seconds during use。
Compared with prior art, the beneficial effects of the present invention is:
1) collutory of the present invention is applied widely, easy to use, has the effect of cleaning, antibacterial, anti-caries and fresh breath, without any side effects；Meanwhile, it is capable to promote the calcification of tooth, prevent and treat gingival hemorrhage。
2) adding old tea in collutory of the present invention, it contains abundant acid element, can stop capillary hemorrhage。Obvious therapeutic effect is had to suffering from stomatitis, abscess of the tongue, eczema, gingival hemorrhage etc.。
Detailed description of the invention
Below in conjunction with specific embodiment, the technique effect of the present invention is described further, in order to the understanding of same domain technical staff。
Embodiment 1
A kind of antibacterial hemostasis collutory, is made up of the raw material of following weight: activated calcium powder 0.8 part, Flos Lonicerae extract 1.2 parts, propolis 0.9 part, paeonol 0.3 part, deep sea salt 1 part, Folium Menthae extract 0.3 part, stevioside 1.8 parts, Folium Eriobotryae 0.8 part, Eucalyptus oil 0.2 part, old tea liquid 2.5 parts, pure water 92 parts。
Described old tea liquid refers to the soaked placement tea of 15～18 hours of Folium Camelliae sinensis, and it is after high temperature sterilize processes, standby。
The preparation technology of described activated calcium powder is: chooses marine organisms Concha Ostreae and removes impurity, dries 1 hour for 100 DEG C, after preliminary pulverizing, calcines 3～8 hours, obtain the superfine active calcium powder that particle diameter is 1～100 μm under 900～1000 DEG C of hot conditionss。
The preparation technology of described Flos Lonicerae extract is: 1) mark 1:8～10 weigh new fresh honeysuckle and pure water by weight；2) Flos Lonicerae is immersed water in 80 DEG C of pure water and carry 1.5 hours；3) repeat step 1), 2) twice, it is that after 1.12～1.14,60 DEG C of vacuum dryings, gained powder is Flos Lonicerae extract that gained solution decompression is concentrated into after filtration concentrated solution relative density。
The preparation technology of described Folium Menthae extract is: 1) score ratio 1:10～20 weigh mentha leave and petroleum ether by weight；2) mentha leave is immersed soaking at room temperature 3 hours in petroleum ether；3) repeat step 1), 2) three times, after filtration, extracting solution is merged, uses Rotary Evaporators steaming petroleum ether, obtain Folium Menthae extract with anhydrous sodium sulfate dehydration。
The preparation method of described antibacterial hemostasis collutory is: 1) weigh raw material according to said ratio；2), after each raw material weighed being mixed, stir；3) heating is to 50～60 DEG C, and is incubated 1～2 hour, then stands to room temperature；4) ultrasonic disperse is after 5～10 minutes, sterile filling。
Using method: diet or use after smoking, discharge best results after collutory being kept in the mouth 5～7 seconds during use。
Embodiment 2
A kind of antibacterial hemostasis collutory, is made up of the raw material of following weight: activated calcium powder 0.5 part, Flos Lonicerae extract 0.1 part, propolis 0.1 part, paeonol 0.2 part, deep sea salt 0.1 part, Folium Menthae extract 0.1 part, stevioside 0.5 part, Folium Eriobotryae 0.5 part, Eucalyptus oil 0.1 part, old tea liquid 2 parts, pure water 90 parts。
Described old tea liquid refers to the soaked placement tea of 15～18 hours of Folium Camelliae sinensis, and it is after high temperature sterilize processes, standby。
The preparation technology of described activated calcium powder is: chooses marine organisms Concha Ostreae and removes impurity, dries 1 hour for 100 DEG C, after preliminary pulverizing, calcines 3～8 hours, obtain the superfine active calcium powder that particle diameter is 1～100 μm under 900～1000 DEG C of hot conditionss。
The preparation technology of described Flos Lonicerae extract is: 1) mark 1:8～10 weigh new fresh honeysuckle and pure water by weight；2) Flos Lonicerae is immersed water in 80 DEG C of pure water and carry 1.5 hours；3) repeat step 1), 2) twice, it is that after 1.12～1.14,60 DEG C of vacuum dryings, gained powder is Flos Lonicerae extract that gained solution decompression is concentrated into after filtration concentrated solution relative density。
The preparation technology of described Folium Menthae extract is: 1) score ratio 1:10～20 weigh mentha leave and petroleum ether by weight；2) mentha leave is immersed soaking at room temperature 3 hours in petroleum ether；3) repeat step 1), 2) three times, after filtration, extracting solution is merged, uses Rotary Evaporators steaming petroleum ether, obtain Folium Menthae extract with anhydrous sodium sulfate dehydration。
The preparation method of described antibacterial hemostasis collutory is: 1) weigh raw material according to said ratio；2), after each raw material weighed being mixed, stir；3) heating is to 50～60 DEG C, and is incubated 1～2 hour, then stands to room temperature；4) ultrasonic disperse is after 5～10 minutes, sterile filling。
Using method: diet or use after smoking, discharge best results after collutory being kept in the mouth 5～7 seconds during use。
Embodiment 3
A kind of antibacterial hemostasis collutory, is made up of the raw material of following weight: activated calcium powder 1 part, Flos Lonicerae extract 2 parts, propolis 1.5 parts, paeonol 0.5 part, deep sea salt 2 parts, Folium Menthae extract 0.5 part, stevioside 3 parts, Folium Eriobotryae 1 part, Eucalyptus oil 0.3 part, old tea liquid 3 parts, pure water 95 parts。
Described old tea liquid refers to the soaked placement tea of 15～18 hours of Folium Camelliae sinensis, and it is after high temperature sterilize processes, standby。
The preparation technology of described activated calcium powder is: chooses marine organisms Concha Ostreae and removes impurity, dries 1 hour for 100 DEG C, after preliminary pulverizing, calcines 3～8 hours, obtain the superfine active calcium powder that particle diameter is 1～100 μm under 900～1000 DEG C of hot conditionss。
The preparation technology of described Flos Lonicerae extract is: 1) mark 1:8～10 weigh new fresh honeysuckle and pure water by weight；2) Flos Lonicerae is immersed water in 80 DEG C of pure water and carry 1.5 hours；3) repeat step 1), 2) twice, it is that after 1.12～1.14,60 DEG C of vacuum dryings, gained powder is Flos Lonicerae extract that gained solution decompression is concentrated into after filtration concentrated solution relative density。
The preparation technology of described Folium Menthae extract is: 1) score ratio 1:10～20 weigh mentha leave and petroleum ether by weight；2) mentha leave is immersed soaking at room temperature 3 hours in petroleum ether；3) repeat step 1), 2) three times, after filtration, extracting solution is merged, uses Rotary Evaporators steaming petroleum ether, obtain Folium Menthae extract with anhydrous sodium sulfate dehydration。
The preparation method of described antibacterial hemostasis collutory is: 1) weigh raw material according to said ratio；2), after each raw material weighed being mixed, stir；3) heating is to 50～60 DEG C, and is incubated 1～2 hour, then stands to room temperature；4) ultrasonic disperse is after 5～10 minutes, sterile filling。
Using method: diet or use after smoking, discharge best results after collutory being kept in the mouth 5～7 seconds during use。

Claims (3)

1. an antibacterial hemostasis collutory, it is characterised in that: this collutory is made up of the raw material of following weight: activated calcium powder 0.5～1 part, Flos Lonicerae extract 0.1～2 part, propolis 0.1～1.5 part, paeonol 0.2～0.5 part, deep sea salt 0.1～2 part, Folium Menthae extract 0.1～0.5 part, stevioside 0.5～3 part, Folium Eriobotryae 0.5～1 part, Eucalyptus oil 0.1～0.3 part, old tea liquid 2～3 parts, pure water 90～95 parts。
2. a kind of antibacterial hemostasis collutory as claimed in claim 1, it is characterised in that: this collutory is made up of the raw material of following weight: activated calcium powder 0.8 part, Flos Lonicerae extract 1.2 parts, propolis 0.9 part, paeonol 0.3 part, deep sea salt 1 part, Folium Menthae extract 0.3 part, stevioside 1.8 parts, Folium Eriobotryae 0.8 part, Eucalyptus oil 0.2 part, old tea liquid 2.5 parts, pure water 92 parts。
3. a kind of antibacterial hemostasis collutory as claimed in claim 1, it is characterised in that: described old tea liquid refers to the soaked placement tea of 15～18 hours of Folium Camelliae sinensis, and it processes through high temperature sterilize。
CN201610130506.3A 2016-03-04 2016-03-04 Mouthwash having bacteriostatic and bleeding stopping effects and preparation method of mouthwash Pending CN105687083A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109846751A (en) * 2019-04-11 2019-06-07 珠海市尼诺生物科技有限公司 A kind of sea salt mouthwash
CN111743790A (en) * 2020-07-21 2020-10-09 广东盐业健康产业发展有限公司 Low-viscosity sea salt oral care mouth wash

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109846751A (en) * 2019-04-11 2019-06-07 珠海市尼诺生物科技有限公司 A kind of sea salt mouthwash
CN111743790A (en) * 2020-07-21 2020-10-09 广东盐业健康产业发展有限公司 Low-viscosity sea salt oral care mouth wash

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Application publication date: 20160622