CN108444803A - A kind of quantitative sampled plasma CD - Google Patents
A kind of quantitative sampled plasma CD Download PDFInfo
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- CN108444803A CN108444803A CN201810450269.8A CN201810450269A CN108444803A CN 108444803 A CN108444803 A CN 108444803A CN 201810450269 A CN201810450269 A CN 201810450269A CN 108444803 A CN108444803 A CN 108444803A
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- quantitative
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- 238000001514 detection method Methods 0.000 abstract description 14
- 210000004369 blood Anatomy 0.000 abstract description 12
- 239000008280 blood Substances 0.000 abstract description 12
- 238000012360 testing method Methods 0.000 abstract description 8
- 238000013461 design Methods 0.000 abstract description 2
- 230000010354 integration Effects 0.000 abstract description 2
- 238000003860 storage Methods 0.000 abstract description 2
- 210000002381 plasma Anatomy 0.000 description 38
- 239000000243 solution Substances 0.000 description 16
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 230000008569 process Effects 0.000 description 3
- 210000002798 bone marrow cell Anatomy 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 208000014951 hematologic disease Diseases 0.000 description 2
- 208000019838 Blood disease Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 206010011409 Cross infection Diseases 0.000 description 1
- 206010029803 Nosocomial infection Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 210000001772 blood platelet Anatomy 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 230000000093 cytochemical effect Effects 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000007723 die pressing method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 208000018706 hematopoietic system disease Diseases 0.000 description 1
- 208000007475 hemolytic anemia Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000000465 moulding Methods 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/38—Diluting, dispersing or mixing samples
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- Physics & Mathematics (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The invention discloses a kind of quantitative sampled plasma CDs, including CD, the gatherer being located on CD and the proportioning device being located on CD；Gatherer includes ingress pipe, the isocon being connect with ingress pipe, the non-return pipe being connect with isocon and the delivery line being connect with non-return pipe；Proportioning device includes quantitative pond and run-off；The input terminal in quantitative pond is connect with isocon；The output end in the quantitative pond is connect with run-off.The present invention uses Integration Design, can complete the work such as quantitative collection and storage, and coordinate and complete subsequent detection work, effectively shorten the blood testing time, reduces detection at many patients capable of being given to provide more good medical services.
Description
Technical field
The present invention relates to blood testing fields, and in particular to a kind of quantitative sampled plasma CD.
Background technology
Clinical blood detection can be divided into blood generally detect, the test in laboratory of hemolytic anemia, bone marrow cell detect,
Bracket for blood grouping and cross match blood test.It can detect that the hematology of common hematological diseases holds sign.
One of the most common is that blood generally detects（That is blood routine）.I.e. to red blood cell, leucocyte and blood platelet these three
The amount and matter of system are detected and analyze.It is also wanted with the relevant detection of various diseases if blood disease is in addition to blood routine to be detected
Carry out bone marrow cell detection, blood cyto-chemical stain analysis etc.；It is main for the blood testing project of hepatopathy and kidney patient
Detection etc. including liver function, renal function；And for some communicable diseases, the detection of antibodies in blood is the weight of diagnosis
It will foundation.
Traditional detection means is detected for some index or certain specific substance after sample collection, is examined
Ranging sequence is more, and the detection of a routine needs more more equipment operations of people, and detection time is long, and testing cost is high, is its outstanding feature.
Especially it is certain need to be detected using reagent in the case of, a variety of interference such as sample error, instrumental error, human error
Factor can all influence testing result.Although the spreading speed of automatic detection system is obviously accelerated in recent years, easily tens
Ten thousand purchase costs even up to a million, general hospital and testing agency are difficult to bear.Especially blood testing parameter is various, inspection
Measurement equipment inevitably has specific aim again, also exacerbates this trend from another point of view.
Invention content
The present invention is intended to provide a kind of quantitative sampled plasma CD easy to use.
The present invention adopts the following technical scheme that：
A kind of quantitative sampled plasma CD, including CD, the gatherer being located on CD and the quantitative dress being located on CD
It sets；
The gatherer includes ingress pipe, the isocon being connect with ingress pipe, the non-return pipe and and non-return being connect with isocon
The delivery line of pipe connection；
The proportioning device includes quantitative pond and run-off；
The input terminal in the quantitative pond is connect with isocon；The output end in the quantitative pond is connect with run-off.
As further solution：The quantitative pond is located at isocon close to the side of cd centre.
As further solution：The run-off is located at quantitative pond close to the side of cd centre.
As further solution：The run-off includes the pond A and pond B being connect with pond A；
The pond B is located at sides of the pond A close to quantitative pond；
The output end in the quantitative pond is connect with pond A.
As further solution：The junction of the non-return pipe and delivery line is equipped with changeover portion A；
Minimum range between the changeover portion and cd centre is less than the minimum range between run-off and cd centre.
As further solution：The junction of the ingress pipe and isocon is equipped with changeover portion B.
As further solution：The junction of the isocon and non-return pipe is equipped with changeover portion C.
The good effect that the present invention generates is as follows：
The present invention is more convenient to use.When needing progress blood plasma quantitative, a certain amount of blood plasma is injected by ingress pipe, with
The rotation of CD, blood plasma start to flow along ingress pipe.At this point, the air pressure in non-return pipe is more than quantitative pond and isocon junction
Air pressure, in plasma flow to quantitative pond, extra part is flow in run-off.Run-off is divided into two portions pond A and pond B
Point, extra blood plasma is flow to first in the A of pond, is then flow under the influence of centrifugal force in the B of pond.The plasma volume of injection is stringent
Control ensures not remain in the A of pond.Then, CD rotates backward, and the blood plasma in the B of pond can not escape, and the blood plasma in quantitative pond exists
It is flowed out under the action of centrifugal force, delivery line is flow to along isocon and non-return pipe, finally flow to from delivery line subsequent mixed
Conjunction or detection part.Dedicated quantitative blood plasma pond is coordinated to use, it is quantitative that the present invention can carry out rapidly and accurately blood plasma
Operation.
Carrier used in the present invention is plastic discs, under the production model of scale, can drag down CD rapidly
Manufacturing cost uses the purchase cost of mechanism to reduce hospital with other.Medical services can be obtained by being more people.
It quantitatively needs to use not by multiple operating process, the intermediate demand such as acquisition, separation, quantitative with present blood plasma
Same tool and equipment, whether use cost and time cost are relatively high.But carry out blood plasma quantitative work using the present invention
When, it is only necessary to whole work can be completed in a CD, a large amount of time cost and tool consumption can be saved, when shortening detection
Between, improve detection efficiency.
In conventional blood plasma lock out operation, other than the disposable tool in part, there is also a large amount of use repeatlies
Tool and equipment, therefore there is the risk of pollution and cross-infection, need to increase additional disinfecting steps in operation.And this hair
Bright to use disposable design, whole quantitative and export work is completed on CD, abandons CD after the completion of use, thorough
Bottom has completely cut off the contaminated possibility of sample.
Description of the drawings
Fig. 1 is the structural diagram of the present invention；
Wherein：11 ingress pipes, 12 isocons, 13 non-return pipes, 14 delivery lines, 21 quantitative ponds, 22 pond A, 23 pond B, 3 changeover portion A, 4
Changeover portion B, 5 changeover portion C.
Specific implementation mode
With reference to Fig. 1, invention is further explained.
The present invention adopts the following technical scheme that：
A kind of quantitative sampled plasma CD, including CD, the gatherer being located on CD and the quantitative dress being located on CD
It sets；
The gatherer includes ingress pipe 11, the isocon being connect with ingress pipe 11 12, the non-return pipe being connect with isocon 12
13 and the delivery line 14 that is connect with non-return pipe 13；
The proportioning device includes quantitative pond 21 and run-off；
The input terminal in the quantitative pond 21 is connect with isocon 12；The output end in the quantitative pond 21 is connect with run-off.
As further solution：The quantitative pond 21 is located at isocon 12 close to the side of cd centre.
As further solution：The run-off is located at quantitative pond 21 close to the side of cd centre.
As further solution：The run-off includes the pond A22 and pond B23 being connect with pond A22；
The pond B23 is located at sides of the pond A22 close to quantitative pond 21；
The output end in the quantitative pond 21 is connect with pond A22.
As further solution：The junction of the non-return pipe 13 and delivery line 14 is equipped with changeover portion A3；
Minimum range between the changeover portion 3 and cd centre is less than the minimum range between run-off and cd centre.
As further solution：The ingress pipe 11 and the junction of isocon 12 are equipped with changeover portion B4.
As further solution：The junction of the isocon 12 and non-return pipe 13 is equipped with changeover portion C5.
It is described further to structure of the invention and using process with reference to actual operating process.
The present invention needs to coordinate dedicated centrifugally operated equipment, each operation that CD is store in the equipment required
Rotation time and velocity of rotation.The centrifugally operated equipment repeats no more not within the protection domain of the application.
CD mentioned in the present invention is made of high molecule plastic, and quantitative pond 21 and run-off etc. are made of molding,
Ingress pipe 11, isocon 12, non-return pipe 13 and delivery line 14 etc. are made of accurate die pressing or etching, are integrated in a CD
On.
In use, CD is placed in centrifugally operated equipment, blood plasma is injected into ingress pipe 11.Meanwhile in order into
One step improves the convenience and degree of integration of operation, can increase a quantitative blood plasma pond on CD.It quantifies blood plasma pond and leads
Entering the connection of pipe 11, blood plasma is injected into quantitative blood plasma pond by when use, when CD rotates, work of the internal blood plasma in centrifugal force
Ingress pipe 11 is flow under.
The blood plasma of ingress pipe 11 is flow under the influence of centrifugal force in isocon 12, and isocon 12 is with quantitative pond 21 and only
Return pipe 13 connects.With the help of changeover portion A3, the gas pressure of non-return pipe 13 and 12 junction of isocon is more than quantitative pond
21 with the gas pressure of 12 junction of isocon, therefore the whole quantitative pond of flow direction 21 of blood plasma.
Gas pressure is made herein and being explained further：The caliber and non-return pipe 13 of isocon 12 and quantitative 21 junction of pond
Caliber it is close, when CD initial rotation, the medium in the two is air, therefore pressure formula P=ρ gh of reference fluids, when
When the length of non-return pipe 13 is more than the maximum distance between pond A22 and isocon 12, non-return pipe 13 and 12 junction of isocon
Gas pressure can be more than the gas pressure in quantitative pond 21 and 12 junction of isocon.Simultaneously in order to ensure pressure value at this,
The length that actual manufacturing process stops return pipe 13 can be far longer than the maximum distance between pond A22 and isocon 12.
Blood plasma fills quantitative pond 21, and extra part is flow in the A22 of pond.Under the influence of centrifugal force, in the A22 of pond
Liquid is flow in the B23 of pond, while being ensured in the A22 of pond without plasma residence.The volume in blood plasma injection rate or quantitative blood plasma pond
When less than the sum of volume of quantitative pond 2 and pond B23 and more than quantitative pond 21, which can be guaranteed.Therefore to blood plasma
Injection rate or quantitative blood plasma pond all must be strictly controlled.
Then CD rotates backward, and the blood plasma in the B23 of pond is motionless, then the blood plasma outflow in quantitative pond 21 is flow to afterwards
In non-return pipe 13, finally it is discharged from delivery line 14.When CD rotates backward, in the rotation direction, non-return pipe 13 is located at quantitative
The rear in pond 21, delivery line 14 are located at the rear of non-return pipe 13.The direction of relative movement of blood plasma with CD rotation direction on the contrary, because
This is flowed into non-return pipe 13 and delivery line 14 rather than in ingress pipe 11.
The rear of ingress pipe 11 can access blood plasma storage pool either reaction tank the blood plasma after quantitative is detected or
Reagents are detected.
Changeover portion A3, changeover portion B4 are identical with the effect of changeover portion C5, are for making the flowing of blood plasma more smooth.
Finally it should be noted that the above embodiments are merely illustrative of the technical solutions of the present invention, rather than its limitations, although
Present invention has been described in detail with reference to the aforementioned embodiments, it will be understood by those of ordinary skill in the art that, still may be used
To modify to the technical solution recorded in previous embodiment or equivalent replacement of some of the technical features, and
These modifications or replacements, the spirit and model of technical solution of the embodiment of the present invention that it does not separate the essence of the corresponding technical solution
It encloses.
Claims (7)
1. a kind of quantitative sampled plasma CD, it is characterised in that：Including CD, the gatherer being located on CD and it is located at light
Proportioning device on disk；
The gatherer includes ingress pipe（11）With ingress pipe（11）The isocon of connection（12）With isocon（12）Connection
Non-return pipe（13）With with non-return pipe（13）The delivery line of connection（14）；
The proportioning device includes quantitative pond（21）And run-off；
The quantitative pond（21）Input terminal and isocon（12）Connection；The quantitative pond（21）Output end and run-off connect
It connects.
2. a kind of quantitative sampled plasma CD according to claim 1, it is characterised in that：The quantitative pond（21）It is located at
Isocon（12）Close to the side of cd centre.
3. a kind of quantitative sampled plasma CD according to claim 2, it is characterised in that：The run-off is located at quantitative
Pond（21）Close to the side of cd centre.
4. a kind of quantitative sampled plasma CD according to claim 3, it is characterised in that：The run-off includes pond A
（22）With with pond A（22）The pond B of connection（23）；
The pond B（23）Positioned at pond A（22）Close to quantitative pond（21）Side；
The quantitative pond（21）Output end and pond A（22）Connection.
5. a kind of quantitative sampled plasma CD according to claim 1, it is characterised in that：The non-return pipe（13）With lead
Outlet pipe（14）Junction be equipped with changeover portion A（3）；
The changeover portion（3）Minimum range between cd centre is less than the minimum range between run-off and cd centre.
6. a kind of quantitative sampled plasma CD according to claim 1, it is characterised in that：The ingress pipe（11）With point
Flow tube（12）Junction be equipped with changeover portion B（4）.
7. a kind of quantitative sampled plasma CD according to claim 1, it is characterised in that：The isocon（12）With only
Return pipe（13）Junction be equipped with changeover portion C（5）.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810450269.8A CN108444803A (en) | 2018-05-11 | 2018-05-11 | A kind of quantitative sampled plasma CD |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810450269.8A CN108444803A (en) | 2018-05-11 | 2018-05-11 | A kind of quantitative sampled plasma CD |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108444803A true CN108444803A (en) | 2018-08-24 |
Family
ID=63202893
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201810450269.8A Pending CN108444803A (en) | 2018-05-11 | 2018-05-11 | A kind of quantitative sampled plasma CD |
Country Status (1)
| Country | Link |
|---|---|
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Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080073297A1 (en) * | 2006-09-27 | 2008-03-27 | Fujifilm Corporation | Method and tool for collecting blood plasma |
| CN103464230A (en) * | 2013-09-25 | 2013-12-25 | 中国科学院长春光学精密机械与物理研究所 | Centrifugal whole blood analysis micro-fluidic chip, preparation method as well as application method thereof |
| CN104678117A (en) * | 2015-02-15 | 2015-06-03 | 石家庄禾柏生物技术股份有限公司 | Automatic temperature-control detector of integrated type quantitative-sampling and reagent-filling device |
| CN207330940U (en) * | 2017-08-11 | 2018-05-08 | 深圳市芯思微生物科技有限公司 | Micro-fluidic chip |
| CN208270310U (en) * | 2018-05-11 | 2018-12-21 | 石家庄禾柏生物技术股份有限公司 | A kind of quantitative sampled plasma CD |
-
2018
- 2018-05-11 CN CN201810450269.8A patent/CN108444803A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080073297A1 (en) * | 2006-09-27 | 2008-03-27 | Fujifilm Corporation | Method and tool for collecting blood plasma |
| CN103464230A (en) * | 2013-09-25 | 2013-12-25 | 中国科学院长春光学精密机械与物理研究所 | Centrifugal whole blood analysis micro-fluidic chip, preparation method as well as application method thereof |
| CN104678117A (en) * | 2015-02-15 | 2015-06-03 | 石家庄禾柏生物技术股份有限公司 | Automatic temperature-control detector of integrated type quantitative-sampling and reagent-filling device |
| CN207330940U (en) * | 2017-08-11 | 2018-05-08 | 深圳市芯思微生物科技有限公司 | Micro-fluidic chip |
| CN208270310U (en) * | 2018-05-11 | 2018-12-21 | 石家庄禾柏生物技术股份有限公司 | A kind of quantitative sampled plasma CD |
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