CN208270302U - A kind of centrifugal plasma separation CD - Google Patents
A kind of centrifugal plasma separation CD Download PDFInfo
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- CN208270302U CN208270302U CN201820702264.5U CN201820702264U CN208270302U CN 208270302 U CN208270302 U CN 208270302U CN 201820702264 U CN201820702264 U CN 201820702264U CN 208270302 U CN208270302 U CN 208270302U
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- 238000000926 separation method Methods 0.000 title abstract description 13
- 210000002381 plasma Anatomy 0.000 claims abstract description 75
- 210000004369 blood Anatomy 0.000 claims abstract description 40
- 239000008280 blood Substances 0.000 claims abstract description 40
- 238000001514 detection method Methods 0.000 abstract description 17
- 238000012360 testing method Methods 0.000 abstract description 8
- 239000000243 solution Substances 0.000 description 24
- 238000000034 method Methods 0.000 description 3
- 210000002798 bone marrow cell Anatomy 0.000 description 2
- 208000014951 hematologic disease Diseases 0.000 description 2
- 208000019838 Blood disease Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 210000001772 blood platelet Anatomy 0.000 description 1
- 238000009534 blood test Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 230000000093 cytochemical effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000007723 die pressing method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000009826 distribution Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 210000003743 erythrocyte Anatomy 0.000 description 1
- 238000005530 etching Methods 0.000 description 1
- 208000018706 hematopoietic system disease Diseases 0.000 description 1
- 208000007475 hemolytic anemia Diseases 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 210000003734 kidney Anatomy 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000003340 mental effect Effects 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
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- Investigating Or Analysing Biological Materials (AREA)
Abstract
The utility model discloses a kind of centrifugal plasmas to separate CD, including CD, the separator being located on CD and the quantitative collection device being located on CD.Separator includes being located at whole blood pond, blood plasma pond and conduit, and one end of conduit is connect with whole blood pond, and the other end is connect with blood plasma pond.Quantitative collection device includes quantitative pond, the run-off connecting with quantitative pond and connecting tube, and one end of connecting tube is connect with quantitative pond, and the other end is connect with blood plasma pond.Originally make utility model in such a way that centrifuge separation is combined with quantitative separating, the blood plasma of more parts of equivalent can be isolated from a whole blood, effectively shorten disengaging time, avoid the various errors being likely to occur in artificial separation, detection speed and detection accuracy can also be improved simultaneously, further increase the level of blood testing.
Description
Technical field
The utility model relates to blood testing fields, and in particular to a kind of centrifugal plasma separation CD.
Background technique
Clinical blood detection can be divided into blood generally detect, the laboratory testing of hemolytic anemia, bone marrow cell detect,
Bracket for blood grouping and cross match blood test.The hematology that can detecte out common hematological diseases holds sign.
One of the most common is that blood generally detects (i.e. blood routine).I.e. to red blood cell, leucocyte and blood platelet these three
The amount and matter of system are detected and are analyzed.Detection relevant to various diseases is also wanted if blood disease is in addition to blood routine to be detected
Carry out bone marrow cell detection, blood cyto-chemical stain analysis etc.；It is main for the blood testing project of hepatopathy and kidney patient
Including liver function, detection of renal function etc.；And for some communicable diseases, the detection of antibodies in blood is the weight of diagnosis
It will foundation.
Traditional detection means is to detect after sample collection for some index or certain specific substance, is examined
Ranging sequence is more, and the detection of a routine needs more more equipment operations of people, and detection time is long, and it is its outstanding feature that testing cost is high.
Especially it is certain need to be detected using reagent in the case where, a variety of interference such as sample error, instrumental error, human error
Factor can all influence testing result.Although the spreading speed of automatic detection system is obviously accelerated in recent years, easily tens
Ten thousand purchase costs even up to a million, general hospital and testing agency are difficult to bear.Especially blood testing parameter is various, inspection
Measurement equipment inevitably has specific aim again, also exacerbates this trend from another point of view.
Utility model content
The utility model be intended to provide it is a kind of can simultaneous quantitative isolate the centrifugal plasma separation CD of more points of blood plasma.
The utility model adopts the following technical solution:
A kind of centrifugal plasma separates CD, determines including CD, the separator being located on CD and being located on CD
Measure acquisition device；
The separator includes being located at whole blood pond, blood plasma pond and conduit；
One end of the conduit is connect with whole blood pond, and the other end is connect with blood plasma pond；
The quantitative collection device includes quantitative pond, the run-off connecting with quantitative pond and connecting tube；
One end of the connecting tube is connect with quantitative pond, and the other end is connect with blood plasma pond.
As further solution: the leading flank in the whole blood pond and trailing flank are made of a plurality of curve；Arbitrarily
The center of curvature of one curve is located on the axis of CD.
As further solution: the leading flank in the blood plasma pond and trailing flank are made of a plurality of curve；Arbitrarily
The center of curvature of one curve is located on the axis of CD.
As further solution: the center of curvature of the axis of the conduit is located on the axis of CD.
As further solution: on the direction vertically with CD, there are the curved surfaces that one passes through catheter shaft line；Institute
It states curved surface and whole blood pond is divided into top half and lower half portion；The top half is close to the part of CD axis；On described
Half part and the volume ratio of lower half portion are 3:2.
As further solution: the run-off is located at quantitative pond close to the side of cd centre.
As further solution: the quantitative pond surrounds the axis circular array of CD；The quantitative pond is successively
Series connection；The run-off only corresponding quantitative pond connection.
As further solution: the separator further includes diversion pipe；The both ends of the diversion pipe respectively with
Adjacent quantitative pond connection；The center of curvature of the diversion pipe is located on the axis of CD.
As further solution: the quantitative collection device further includes aerial drainage pond；
The aerial drainage pond is connect with the last one run-off；
One end of the connecting tube is connect with first blood plasma pond.
As further solution: the minimum range of the aerial drainage pond and cd centre is greater than in run-off and CD
The minimum range of the heart.
The good effect that the utility model generates is as follows:
The utility model sub-argument can go out more points of blood plasma in a blood plasma mask work, and separative efficiency is higher.In use,
Blood is injected into whole blood pond, under the influence of centrifugal force, blood is separated into blood plasma and haemocyte, right in plasma flow to blood plasma pond
After be then transferred in each quantitative pond.In this way, first separation operation can isolate more points of blood plasma, separation can be greatly shortened
Time improves separative efficiency.
The more points of Plasma volumes equalizations that the utility model is isolated avoid tradition separation after the completion again by manually-operated
Mask work improves the precision of Quantitative Separation.The volume in each quantitative pond is equal on CD, blood plasma by blood plasma pond into
Enter during quantifying pond to each, extra part is automatically transferred in run-off and aerial drainage pond, to guarantee each
It is filled by blood plasma in quantitative pond.More points of blood plasma of the equivalent isolated just can be directly used for detection operation, effectively shorten
Detection time particular avoids the secondary pollution being likely to occur in artificial lock out operation and quantitative error, can give subsequent
Detection work provides solid guarantee.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the utility model；
Wherein: 11 whole blood ponds, 12 blood plasma ponds, 13 conduits, 21 quantitative ponds, 22 run-offs, 23 connecting tubes, 3 diversion pipes, 4 are let out
Flow pond.
Specific embodiment
The utility model is further described below with reference to Fig. 1.
The utility model adopts the following technical solution:
A kind of centrifugal plasma separates CD, determines including CD, the separator being located on CD and being located on CD
Measure acquisition device；
The separator includes being located at whole blood pond 11, blood plasma pond 12 and conduit 13；
One end of the conduit 13 is connect with whole blood pond 11, and the other end is connect with blood plasma pond 12；
The quantitative collection device includes quantitative pond 21, the run-off 22 connecting with quantitative pond 21 and connecting tube 23；
One end of the connecting tube 23 is connect with quantitative pond 21, and the other end is connect with blood plasma pond 12.
As further solution: the leading flank in the whole blood pond 11 and trailing flank are made of a plurality of curve；Appoint
The center of curvature of one curve of meaning is located on the axis of CD.
As further solution: the leading flank in the blood plasma pond 12 and trailing flank are made of a plurality of curve；Appoint
The center of curvature of one curve of meaning is located on the axis of CD.
As further solution: the center of curvature of the axis of the conduit 13 is located on the axis of CD.
As further solution: on the direction vertically with CD, there are the curved surfaces that one passes through 13 axis of conduit；
The curved surface divides in whole blood pond 11 for top half and lower half portion；The top half is close to the part of CD axis；Institute
The volume ratio for stating top half and lower half portion is 3:2.
As further solution: the run-off 22 is located at quantitative pond 21 close to the side of cd centre.
As further solution: the quantitative pond 21 surrounds the axis circular array of CD；The quantitative pond 21
It is sequentially connected in series；Only corresponding quantitative pond 21 connects the run-off 22.
As further solution: the separator further includes diversion pipe 3；Distinguish at the both ends of the diversion pipe 3
It is connect with adjacent quantitative pond 21；The center of curvature of the diversion pipe 3 is located on the axis of CD.
As further solution: the quantitative collection device further includes aerial drainage pond 4；
The aerial drainage pond 4 is connect with the last one run-off 22；
One end of the connecting tube 23 is connect with first blood plasma pond 12.
As further solution: the aerial drainage pond 4 and the minimum range of cd centre are greater than run-off 22 and light
The minimum range of disk center.
The utility model is further described below with reference to the actual course of work.
The utility model needs to cooperate dedicated centrifugally operated equipment, stores needed for each operation of CD in the equipment
The rotation time and velocity of rotation wanted.The centrifugally operated equipment not within the scope of protection of this application, therefore repeats no more.
The CD mentioned in the utility model is made of high molecule plastic, and whole blood pond 11 and blood plasma pond 12 etc. use mould
Compacting is made, and connecting tube 23 and conduit 13 etc. are integrated on a CD using accurate die pressing or etching production.
In use, whole blood is injected into whole blood pond 11, then start centrifugally operated equipment, CD starts turning.From
Under the action of mental and physical efforts, whole blood is separated into blood plasma and haemocyte, and the volume of blood plasma is about the 60% of volume of whole blood, the body of haemocyte
Product is about the 40% of whole blood.
The blood plasma isolated is flow in blood plasma pond 12 by conduit 13, is then flow to respectively along connecting tube 23 each
In a quantitative pond 21.With the injection of blood plasma, quantitative pond 21 is gradually filled.Air a part in quantitative pond 21 is transferred to down
In one quantitative pond, another part is extruded in run-off 22, while extra part blood plasma is also flow in run-off 22.
As the air in run-off 22 is compressed, pressure is also gradually increased.After pressure increase to a certain extent in run-off 22,
Blood plasma does not enter back into.Blood plasma starts to flow and repeat the process to second quantitative pond 21 at this time, until whole quantitative ponds 21
Filled by blood plasma.
The air sent in quantitative pond 21 is finally transferred completely into aerial drainage pond 4, and extra blood plasma out, which is equally transferred to, to be let out
It flows in pond 4.
So far, blood plasma mask work is completed, and separation number is determined by the quantity in quantitative pond 21, because of each quantitative pond 21
Volume be all equal, therefore the every a blood plasma isolated all is equivalent.It is taken out from quantitative pond 21 can
Carry out subsequent detection process.
From the point of view of analysis, a sample can make multiple detection samples, substantially reduce sample time, simultaneously
The sample of more parts of equivalent in turn avoids the error that subsequent artefacts divide sample to generate, and can significantly improve subsequent detection accuracy.
It makes and being explained further below for the specific structure of the utility model:
The leading flank in whole blood pond 11 is just proximate to the curved surface of cd centre, forms the curve parallel with CD of the curved surface
The center of curvature is respectively positioned on the axis of CD, and such purpose is for haemocyte, the distribution of centrifugal force be it is uniform,
Be not in the phenomenon that centrifugal force is bigger than normal or less than normal in a certain region, cause blood separation part unbalance, in turn result in separation
Haemocyte situation on the high side in blood plasma out.The structure in blood plasma pond 12 is similar with the structure in whole blood pond 11, and details are not described herein again.
The center of curvature of 13 axis of conduit is located on the axis of CD, and the blood plasma that it can be made internal at the uniform velocity flows, and avoids
Blood plasma is layered.
The junction in quantitative pond 21 and blood plasma pond 12 is located at the trailing flank in blood plasma pond 12, and reason is that blood plasma enters
It is mobile to trailing flank under the influence of centrifugal force behind blood plasma pond 12, the residual quantity in blood plasma pond 12 can be preferably minimized in this way,
Improve the utilization rate of blood plasma.
It is connected between quantitative pond 21 by diversion pipe 3, the radius of curvature of each section of diversion pipe 3 is equal, and each section
The center of curvature of diversion pipe 3 is respectively positioned on the axis of CD, can guarantee the plasma flow rate phase in each section of diversion pipe 3 in this way
Deng avoiding the occurrence of the too fast situation for leading to blood plasma deficiency in adjacent quantitative pond 21 of local velocity.
It is compared with run-off 22, aerial drainage pond 4 is farther at a distance from cd centre, is to make the last one run-off in this way
Extra blood plasma can be smoothly transferred in aerial drainage pond 4 in 22, avoid the occurrence of that back pressure is excessive to cause blood plasma that can not shift.Simultaneously
In order to further decrease the air pressure in aerial drainage pond 4, a stomata or gas-guide tube can be increased on aerial drainage pond 4, make its with it is outer
Boundary's atmosphere communicates, and guarantees that the air pressure in aerial drainage pond 4 is equal with external atmospheric pressure always.
Finally it should be noted that above embodiments are only to illustrate the technical solution of the utility model, rather than its limitations,
Although the utility model is described in detail with reference to the foregoing embodiments, those skilled in the art should understand that,
It can still modify to technical solution documented by previous embodiment, or be equal to part of technical characteristic
Replacement, and these are modified or replaceed, the utility model embodiment technical solution that it does not separate the essence of the corresponding technical solution
Spirit and scope.
Claims (10)
1. a kind of centrifugal plasma separates CD, it is characterised in that: including CD, the separator being located on CD and be located at light
Quantitative collection device on disk；
The separator includes being located at whole blood pond (11), blood plasma pond (12) and conduit (13)；
One end of the conduit (13) is connect with whole blood pond (11), and the other end is connect with blood plasma pond (12)；
The quantitative collection device includes quantitative pond (21), the run-off (22) connecting with quantitative pond (21) and connecting tube (23)；
One end of the connecting tube (23) is connect with quantitative pond (21), and the other end is connect with blood plasma pond (12).
2. a kind of centrifugal plasma according to claim 1 separates CD, it is characterised in that: before the whole blood pond (11)
Side and trailing flank are made of a plurality of curve；The center of curvature of any one curve is located on the axis of CD.
3. a kind of centrifugal plasma according to claim 2 separates CD, it is characterised in that: before the blood plasma pond (12)
Side and trailing flank are made of a plurality of curve；The center of curvature of any one curve is located on the axis of CD.
4. a kind of centrifugal plasma according to claim 1 separates CD, it is characterised in that: the axis of the conduit (13)
The center of curvature be located on the axis of CD.
5. a kind of centrifugal plasma according to claim 4 separates CD, it is characterised in that: vertically with the direction of CD
On, there are the curved surfaces that one passes through conduit (13) axis；Whole blood pond (11) are divided into top half and lower half portion by the curved surface；Institute
Stating top half is close to the part of CD axis；The top half and the volume ratio of lower half portion are 3:2.
6. a kind of centrifugal plasma according to claim 1 separates CD, it is characterised in that: the run-off (22) is located at
Quantitative pond (21) are close to the side of cd centre.
7. a kind of centrifugal plasma according to claim 1 separates CD, it is characterised in that: quantitative pond (21) surround
The axis circular array of CD；Quantitative pond (21) are sequentially connected in series；The run-off (22) only corresponding quantitative pond
(21) it connects.
8. a kind of centrifugal plasma according to claim 7 separates CD, it is characterised in that: the separator further includes
Diversion pipe (3)；The both ends of the diversion pipe (3) are connect with adjacent quantitative pond (21) respectively；In the curvature of the diversion pipe (3)
The heart is located on the axis of CD.
9. a kind of centrifugal plasma according to claim 7 separates CD, it is characterised in that: the quantitative collection device is also
Including aerial drainage pond (4)；
The aerial drainage pond (4) connect with the last one run-off (22)；
One end of the connecting tube (23) is connect with first blood plasma pond (12).
10. a kind of centrifugal plasma according to claim 9 separates CD, it is characterised in that: the aerial drainage pond (4) and light
The minimum range of disk center is greater than the minimum range of run-off (22) and cd centre.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820702264.5U CN208270302U (en) | 2018-05-11 | 2018-05-11 | A kind of centrifugal plasma separation CD |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820702264.5U CN208270302U (en) | 2018-05-11 | 2018-05-11 | A kind of centrifugal plasma separation CD |
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| CN208270302U true CN208270302U (en) | 2018-12-21 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108469367A (en) * | 2018-05-11 | 2018-08-31 | 石家庄禾柏生物技术股份有限公司 | A kind of centrifugal plasma separation CD |
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- 2018-05-11 CN CN201820702264.5U patent/CN208270302U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108469367A (en) * | 2018-05-11 | 2018-08-31 | 石家庄禾柏生物技术股份有限公司 | A kind of centrifugal plasma separation CD |
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