CN208399527U - Reagent disc test device that is a kind of while carrying out a variety of diagnosis - Google Patents
Reagent disc test device that is a kind of while carrying out a variety of diagnosis Download PDFInfo
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- CN208399527U CN208399527U CN201820701609.5U CN201820701609U CN208399527U CN 208399527 U CN208399527 U CN 208399527U CN 201820701609 U CN201820701609 U CN 201820701609U CN 208399527 U CN208399527 U CN 208399527U
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- Investigating Or Analysing Biological Materials (AREA)
Abstract
The utility model relates to a kind of reagent disc test devices for carrying out carrying out a variety of diagnosis while a variety of diagnosis simultaneously, it include: CD, the CD is rotation light transmission circle CD, the heart in an optical disc is arranged in axle center for optical disk rotary, the reagent quantitative reaction system for being provided with whole blood separation system on the CD and being connected to respectively with whole blood separation system, the reagent quantitative reaction system is no less than 2 groups, and the reagent quantitative reaction system is uniformly arranged on CD respectively using the center of circle as axle center.The utility model can carry out blood plasma separation using centrifugal force automatically, and rationed blood plasma, from trend blood plasma quantification reagent adding, the utility model can carry out the detection of multiple projects simultaneously.
Description
Technical field
The utility model relates to blood testing fields, and in particular to a kind of reagent looping test dress for carrying out a variety of diagnosis simultaneously
It sets.
Background technique
Clinical blood detection can be divided into blood generally detect, the laboratory testing of hemolytic anemia, bone marrow cell detect,
Bracket for blood grouping and cross match blood test.The hematology that can detecte out common hematological diseases holds sign.
One of the most common is that blood generally detects (i.e. blood routine).I.e. to red blood cell, leucocyte and blood platelet these three
The quality and quantity of system is detected and is analyzed.Detection relevant to various diseases is also wanted if blood disease is in addition to blood routine to be detected
Carry out bone marrow cell detection, blood cyto-chemical stain analysis etc.；It is main for the blood testing project of hepatopathy and kidney patient
Including liver function, detection of renal function etc.；And for some communicable diseases, the detection of antibodies in blood is the weight of diagnosis
It will foundation.
Traditional detection means is to detect after sample collection for some index or certain specific substance, is examined
Ranging sequence is more, and the detection of a routine needs more more equipment operations of people, and detection time is long, and it is its outstanding feature that testing cost is high.
Especially it is certain need to be detected using reagent in the case where, a variety of interference such as sample error, instrumental error, human error
Factor can all influence testing result.Although the spreading speed of automatic detection system is obviously accelerated in recent years, easily tens
Ten thousand purchase costs even up to a million, general hospital and testing agency are difficult to bear.Especially blood testing parameter is various, inspection
Measurement equipment inevitably has specific aim again, also exacerbates this trend from another point of view.
Utility model content
The utility model be intended to provide one kind can automatically using centrifugal force carry out blood plasma separation, rationed blood plasma, from
The reagent disc test device of a variety of diagnosis is carried out while trend blood plasma quantification reagent adding.
The utility model adopts the following technical solution:
A kind of while carry out a variety of diagnosis while, carries out the reagent disc test device of a variety of diagnosis, comprising: CD, it is described
CD is rotation light transmission circle CD, and the axle center for optical disk rotary is arranged the heart in an optical disc, whole blood point is provided on the CD
The reagent quantitative reaction system being connected to from system and respectively with whole blood separation system, the reagent quantitative reaction system are no less than 2
Group, the reagent quantitative reaction system are uniformly arranged on CD respectively using the center of circle as axle center；
The whole blood separation system includes whole blood pond, blood plasma pond, the 5th conduit and the 5th proportioning device；5th conduit
One end connect with whole blood pond, the other end is connect with blood plasma pond；The 5th quantitative collection device includes the 5th quantitative pond, with the
The 5th run-off and the 5th connecting tube of five quantitative pond connections；One end of 5th connecting tube is connect with the 5th quantitative pond, separately
One end is connect with blood plasma pond；
The reagent quantitative reaction system includes the first reagent, the first proportioning device being connected to the first reagent,
Two reagents, the third proportioning device being connected to the second reagent and the cache pool being connected to third proportioning device, described
A certain amount of device, the 5th proportioning device and cache pool are connected to reaction tank respectively, and the reaction tank is light transmission reaction tank.
Preferably, the leading flank in the whole blood pond and trailing flank are made of curve, any one bent curvature of a curve
Center is located on the axis of CD；The leading flank in the blood plasma pond and trailing flank are made of a curve, any one song
Curvature of a curve center is located on the axis of CD；The center of curvature of the axis of 5th conduit is located on the axis of CD；?
Perpendicular on the direction of CD, there are the curved surfaces that one passes through the 5th conduit axis；Whole blood pond is divided into top half by the curved surface
The lower half portion and；The top half is close to the part of CD axis；The top half and the volume ratio of lower half portion are
3:2, adding hole is provided on the whole blood pond, and first reagent is equipped with first row stomata, is arranged on the cache pool
There is second row stomata.
Preferably, the 5th run-off is located at the 5th quantitative pond close to the side of cd centre；Described 5th quantitative pond
Around the axis circular array of CD；5th separator further includes the 5th diversion pipe；The both ends of 5th diversion pipe
It is connect respectively with the adjacent the 5th quantitative pond；The center of curvature of 5th diversion pipe is located on the axis of CD.
Preferably, whole blood separation system further includes aerial drainage pond；The aerial drainage pond is connect with the last one the 5th run-off；Institute
The one end for stating the 5th connecting tube is connect with blood plasma pond；The minimum range of the aerial drainage pond and cd centre be greater than the 5th run-off with
The minimum range of cd centre.
Preferably, first proportioning device quantifies pond and the first run-off including first, after described first quantifies pond
Right side is connected to by the first diversion pipe with the first reagent, and the preceding right side in the described first quantitative pond passes through with the first run-off
The rear left side of the connection of first conduit, the described first quantitative pond is connected to by the first bending tube with reaction tank, first overflow
Downtake pipe is provided at the top of pond；
First bending tube includes the first connecting tube, is connected to the first connecting tube the first fluid stopping pipe, with the first fluid stopping
Pipe First Transition section and the first delivery line being connected to First Transition section, the first delivery line connected reaction pond；
The leading flank in the described first quantitative pond is located at being equidistant for each point in sustained height and cd centre；
The minimum range of the First Transition section and the minimum range of cd centre less than the first conduit and cd centre；
Minimum range of the minimum range of first run-off and cd centre less than the first quantitative pond and cd centre.
Preferably, the third proportioning device includes that third quantifies pond, third run-off and third diversion pipe, the third
Run-off is located at third and quantifies pond close to the side of cd centre；Second reagent is located at third and quantifies pond in CD
The side of the heart；One end of the third diversion pipe is connected to the second reagent, and the other end quantifies pond with third and is connected to；
The third diversion pipe include third conduit A, with the third conduit A U-tube connecting and the third being connect with U-tube
Conduit B；
The other end of the third conduit A is connect with the second reagent；The other end and third of the third conduit B is quantitative
The input terminal in pond connects；The minimum diameter of the third conduit A is greater than the maximum gauge of U-tube；The minimum of the third conduit A
Diameter is greater than the maximum gauge of third conduit B；
The third run-off includes the third pond A and third pond B connecting with third pond A；The third pond B is located at third
Side of the pond A far from cd centre；The third quantifies pond and connect with third pond A；The third quantifies the company in pond Yu third pond A
It meets place and is located at third pond A far from the side of cd centre；
Second reagent is equipped with barometric pipe；The other end of the barometric pipe is connected to whole blood pond.
Preferably, the third conduit C of the cache pool connection；The cache pool is located at third and quantifies pond close to cd centre
Side；The other end of the third conduit C is connect with the input terminal that third quantifies pond；
Surge pipe is additionally provided on the cache pool；The other end of the surge pipe is connected to whole blood pond；On the cache pool
It is additionally provided with the 4th delivery line, the other end of the 4th delivery line is connected to reaction tank；Connect between second reagent and cache pool
It is connected with return pipe；
Minimum range between the third conduit C and cd centre less than between the second reagent and cd centre most
Small distance.
Preferably, two feeding pipes of the reaction tank connection, are communicated with exhaust pipe on the reaction tank, in the row
Exhaust storehouse is provided on tracheae；
First delivery line is connected to feeding pipe, and the 4th delivery line and the second ingress pipe are connected to exhaust storehouse respectively；
The inner wall of the reaction tank is in arc transition, and arc length of the reaction tank horizontal cross-section along optical disk rotary direction is greater than
, perpendicular to the length of direction of rotation, the horizontal cross-section of the reaction tank is oval for it, and the short axle of the reaction tank passes through CD
Rotation center.
Preferably, reagent packet is respectively provided in first reagent and the second reagent.
Preferably, the reagent packet be capsule-type reagent packet, the capsule-type reagent packet include the film to link together,
The sealing pond formed between film and the liquid reagent being filled in sealing pond；Three side of film described in two panels is equipped with edge sealing, described
Edge sealing forms closed loop sealing；The section in the sealing pond is that trapezoidal, trapezoidal upper bottom edge, bottom and a waist edge are equipped with envelope
Side, the film use aluminium film.
The utility model has the beneficial effects that
The utility model can carry out blood plasma separation using centrifugal force automatically, and rationed blood plasma is default from trend blood plasma
Measure reagent adding.
The utility model sub-argument can go out more parts of blood plasma in a blood plasma mask work, and separative efficiency is higher.In use,
Blood is injected into whole blood pond, under the influence of centrifugal force, blood is separated into blood plasma and haemocyte, right in plasma flow to blood plasma pond
After be then transferred in each 5th quantitative pond.In this way, first separation operation can isolate more points of blood plasma, can greatly shorten
Disengaging time improves separative efficiency.
The more parts of Plasma volumes equalizations that the utility model is isolated avoid tradition separation after the completion again by manually-operated
Mask work improves the precision of Quantitative Separation.The volume in each the 5th quantitative pond is equal on CD, and blood plasma is by blood plasma
During pond enters each the 5th quantitative pond, extra part is automatically transferred in the 5th run-off and aerial drainage pond, is used
To guarantee that each the 5th quantitative pond is filled by blood plasma.More parts of blood plasma of the equivalent isolated can be fed directly to reagent
Quantitative reaction system effectively shortens detection time, particular avoiding may in artificial lock out operation for detecting operation
The secondary pollution of appearance and quantitative error can provide solid guarantee to subsequent detection work.
The utility model first quantifies pond and third quantifies the given volume in pond, can dosage needed for accurate quantitative analysis, it is extra
Part be transferred in the first run-off and third run-off respectively automatically, to guarantee that each quantitative pond is filled.Point
The blood plasma separated out, which can be directly entered reaction tank and then different reagents are added, to be reacted, and detection is directly used in after reaction and is made
Industry effectively shortens detection time, particular avoids the secondary pollution being likely to occur in artificial lock out operation and quantitative mistake
Difference can provide solid guarantee to subsequent detection work.
Carrier used in the utility model is plastic discs, under the production model of scale, can drag down light rapidly
The manufacturing cost of disk, to reduce the purchase cost that hospital uses mechanism with other.It is that more people can obtain medical services.
It quantitatively needs with present blood plasma by multiple operating process such as acquisition, separation, quantitative, centre is needed using to not
Same tool and equipment, whether use cost and time cost are relatively high.But it is quantitative to carry out blood plasma using the utility model
When operation, it is only necessary to which whole work can be completed in a CD, can save a large amount of time cost and tool consumption, shorten inspection
The time is surveyed, detection efficiency is improved.
The acquisition cost of the utility model is lower, and collecting efficiency is higher.Traditional acquisition mode is artificial acquisition or machine
Device acquisition, manually staff is operated using dropper, day equality when acquisition, equipment precision, human error, operating error etc.
Disturbing factor is very more, is difficult to carry out precise measurement；Although it is very high that machine acquires precision, meet the equipment of such precision
Price is also very high, and general hospital and use mechanism are also beyond affordability.The utility model innovation is set using optical-disk type
Meter, by the production of scale can make CD cost of manufacture drop to it is very low, it is only smart by manufacture when especially CD acquires
The influence of degree thoroughly avoids various disturbing factors when artificial acquisition, acquisition precision can be improved rapidly, in cost and efficiency
Aspect accomplishes extraordinary balance.
The third run-off of the utility model uses catamaran design, when CD rotates forward, quantifies pond from third and shifts
Reagent enter third pond A, under the influence of centrifugal force, reagent is eventually transferred into the B of third pond.When CD rotates backward, the
Reagent in three pond B has the movement tendency far from cd centre, but third pond B is not connect with quantitative pond, therefore third is fixed
When measuring the reagent outflow in pond, the reagent in the B of third pond is remained stationary, and can guarantee that reagent collection capacity and third quantify pool volume
It is equal, to guarantee acquisition precision.
It is hydraulic higher than hydraulic in U-tube and third conduit B in third conduit A when CD rotates backward.Third is quantitative
Reagent in pond can only flow out during outflow from third conduit C.Anti-return design equally can be improved acquisition essence
Degree.
The utility model uses disc centrifuge structure, and whole blood is separated in whole blood pond, since blood plasma is lighter, red blood cell
Heavier, CD generates centrifugal force by rotation, and under the influence of centrifugal force, heavier red blood cell is located at the outboard end of separate tank,
Lighter blood plasma is located at the inner end of separate tank, and blood plasma separation is then transported to blood plasma pond Quantitative Separation again by going out blood vessel.
The reaction tank of the utility model is arranged on CD, generates centrifugal force for the liquid in reaction tank by the rotation of CD
Body is mixed, and the exhaust storehouse on exhaust pipe can accelerate gas discharge effectively to avoid retaining bubble in reaction tank, is prevented
Detection is had an impact.
Liquid, which can be effectively prevented, in the arc transition inner wall of reaction tank, which carries out accumulation in corner, influences mixed effect, and mixing is more
Add and uniformly guarantees accuracy in detection.The utility model is suitable for optical detection, using light microscopic to reaction during optical disk rotary
Pond is detected, and is increased reaction tank in the length in optical disk rotary direction, can be effectively increased the detection reaction time of sensor, disappear
Except detection error, testing result is more accurate.
Three side of film described in the two panels of the utility model capsule-type reagent packet is equipped with edge sealing, do not set the one side of edge sealing from
It ruptures, enters in the first reagent and the second reagent automatically under the action of mental and physical efforts, the capsule-type reagent packet and the first examination
Agent pond, the second reagent are integrally formed.
The more parts of blood plasma that the utility model is separated have respectively entered different reagent quantitative reaction systems and difference are added
Reagent, the detection and analysis of various projects are then carried out under optics Electronic Speculum.
Detailed description of the invention
Fig. 1 is the structural schematic diagram of the utility model.
Fig. 2 is the structural schematic diagram of the utility model whole blood separation system.
Fig. 3 is the structural schematic diagram of the first proportioning device of the utility model.
Fig. 4 is the structural schematic diagram of the utility model third proportioning device and cache pool.
Fig. 5 is the structural schematic diagram of the utility model reaction tank.
Fig. 6 is the structural schematic diagram of the utility model capsule-type reagent packet.
In attached drawing, 1- CD, the first reagent of 2-, 21- first row stomata, 3- whole blood pond, 31- adding hole, 4- second are tried
Agent pond, 5- cache pool, 51- second row stomata, 6- reaction tank, 8- reagent packet, 9- blood plasma pond, 10- aerial drainage pond, the first water conservancy diversion of 111-
Pipe, 121- first quantify pond, the first run-off of 122-, the first conduit of 123-, 104- changeover portion, 105- downtake pipe, 131-
First connecting tube, the first fluid stopping of 132- pipe, the first delivery line of 133-, 404- third conduit C, 405- surge pipe, 406- the 4th are led
Outlet pipe, 407- barometric pipe, 408- return pipe, 412- third quantify pond, 413 third pond A, 414- third pond B, 415- thirds
Run-off, 421- third conduit, 422-U type pipe, the 5th diversion pipe of 423- third conduit B, 503-, the 5th conduit of 513-, 521-
5th quantitative pond, the 5th run-off of 522-, the 5th connecting tube of 523-, 611- feeding pipe, 610- exhaust pipe, 612- are vented storehouse, 81-
Film, 82- edge sealing.
Specific embodiment
As shown in figures 1 to 6, a kind of while carry out a variety of diagnosis while, carries out the reagent disc test device of a variety of diagnosis, packet
Include: CD 1, the CD 1 are rotation light transmission circle CD, and the heart in an optical disc, the CD is arranged in the axle center rotated for CD 1
The reagent quantitative reaction system for being provided with whole blood separation system on 1 and being connected to respectively with whole blood separation system, the reagent quantitative
Reaction system is 3 groups, and the reagent quantitative reaction system is uniformly arranged on CD 1 respectively using the center of circle as axle center；
The whole blood separation system includes whole blood pond 3, blood plasma pond 9, the 5th conduit 513 and the 5th proportioning device；Described
One end of five conduits 513 is connect with whole blood pond 3, and the other end is connect with blood plasma pond 9；The 5th quantitative collection device includes the 5th
Quantitative pond 521, the 5th run-off 522 being connect with the 5th quantitative pond 521 and the 5th connecting tube 523；5th connecting tube 523
One end connect with the 5th quantitative pond 521, the other end is connect with blood plasma pond 9；
The reagent quantitative reaction system include the first reagent 2, the first proportioning device being connected to the first reagent 2,
Second reagent 4, the third proportioning device being connected to the second reagent 4 and the cache pool 5 being connected to third proportioning device, institute
The first proportioning device, the 5th proportioning device 521 and cache pool 5 is stated to be connected to reaction tank 6 respectively.
Preferably, the leading flank in the whole blood pond 3 and trailing flank are made of curve, any one bent curvature of a curve
Center is located on the axis of CD；The leading flank in the blood plasma pond 9 and trailing flank are made of curve, any one curve
The center of curvature be located on the axis of CD 1；The center of curvature of the axis of 5th conduit 513 is located on the axis of CD 1；
On the direction perpendicular to CD 1, there are the curved surfaces that one passes through 513 axis of the 5th conduit；It is upper that the curved surface, which divides whole blood pond 3,
Half part and lower half portion；The top half is close to the part of CD axis；The body of the top half and lower half portion
Product is provided with adding hole 31, first reagent 2 is equipped with first row stomata 21, described than being 3:2 on the whole blood pond 3
Second row stomata 51, the first row stomata 21 and second row stomata 51 are provided on cache pool 5 for being vented.
Preferably, the 5th run-off 522 is located at the 5th quantitative pond 521 close to the side of cd centre；Described 5th
Quantitative pond 521 surrounds the axis circular array of CD 1；5th separator further includes the 5th diversion pipe 503；Described 5th
The both ends of diversion pipe 503 are connect with the adjacent the 5th quantitative pond 521 respectively；The center of curvature of 5th diversion pipe 503 is located at
On the axis of CD 1.
Preferably, whole blood separation system further includes aerial drainage pond 10；The aerial drainage pond 10 and the last one the 5th run-off 522
Connection；One end of 5th connecting tube 523 is connect with blood plasma pond 9；The aerial drainage pond 10 and the minimum range of cd centre are big
In the minimum range of the 5th run-off 522 and cd centre.
Preferably, first proportioning device includes the first quantitative pond 121 and the first run-off 122, and described first is quantitative
The rear right side in pond 121 is connected to by the first diversion pipe 111 with the first reagent 2, the preceding right side in the described first quantitative pond 121
It is connected to the first run-off 122 by the first conduit 123, the rear left side in the described first quantitative pond 121 passes through the first bending tube
Be connected to reaction tank 6, be provided with downtake pipe 105 at the top of first run-off 122, the downtake pipe 105 with it is complete
Blood pool 3 is connected to；
First bending tube include the first connecting tube 131, the first fluid stopping pipe 132 being connected to the first connecting tube 131, with
The First Transition section 104 of first fluid stopping pipe 132 connection and the first delivery line 133 being connected to First Transition section 104, described first
133 connected reaction pond 6 of delivery line；
The leading flank in the described first quantitative pond 121 is located at being equidistant for each point in sustained height and cd centre；
Minimum of the minimum range of the First Transition section 104 and cd centre less than the first conduit 123 and cd centre
Distance；
First run-off 122 and the minimum range of cd centre quantify pond 121 and cd centre most less than first
Small distance.
Preferably, the third proportioning device includes that third quantifies pond 412, third run-off 415 and third diversion pipe, institute
It states third run-off 415 and is located at third and quantify pond 412 close to the side of cd centre；It is fixed that second reagent 4 is located at third
Pond 412 is measured close to the side of cd centre；One end of the third diversion pipe is connected to the second reagent 4, the other end and third
Quantitative pond 412 is connected to；
The third diversion pipe include third conduit A421, with the third conduit A421 U-tube 422 connecting and and U-tube
The third conduit B423 of 422 connections；
The other end of the third conduit A421 is connect with the second reagent 4；The other end of the third conduit B423 with
Third quantifies the input terminal connection in pond 412；The minimum diameter of the third conduit A421 is greater than the maximum gauge of U-tube 422；Institute
The minimum diameter for stating third conduit A421 is greater than the maximum gauge of third conduit B423；
The third run-off 415 includes third pond A413 and the third pond B414 connecting with third pond A413；Described
Three pond B414 are located at side of the third pond A413 far from cd centre；The third quantifies pond 412 and connect with third pond A413；Institute
It states third and quantifies the junction of pond 412 and third pond A413 and be located at third pond A413 far from the side of cd centre；
Second reagent 4 is equipped with barometric pipe 407.
Preferably, the third conduit C404 that the cache pool 5 connects；The cache pool 5 is located at third, and to quantify pond 412 close
The side of cd centre；The other end of the third conduit C404 is connect with the input terminal that third quantifies pond 412；
Surge pipe 405 is additionally provided on the cache pool 5；The other end of the surge pipe 405 is connected to whole blood pond 3；It is described
The 4th delivery line 406 is additionally provided on cache pool 5, the other end of the 4th delivery line 406 is connected to reaction tank；Second reagent
Return pipe 408 is communicated between 4 and cache pool 5；
Minimum range between the third conduit C404 and cd centre is less than between the second reagent 4 and cd centre
Minimum range.
Preferably, two feeding pipes 611 that the reaction tank 6 is connected to, are communicated with exhaust pipe 610 on the reaction tank 6,
Exhaust storehouse 612 is provided on the exhaust pipe 610, the other end of the exhaust pipe 610 is connected to whole blood pond 3；
First delivery line 133 is connected to feeding pipe 611, the 4th delivery line 406 and the second ingress pipe 311 respectively with row
Gas storehouse 612 is connected to；
The inner wall of the reaction tank 6 is in arc transition, and arc length of the reaction tank horizontal cross-section along optical disk rotary direction is big
In it perpendicular to the length of direction of rotation, the horizontal cross-section of the reaction tank is oval, and the short axle of the reaction tank passes through light
The rotation center of disk.
Preferably, reagent packet 8 is respectively provided in first reagent 2 and the second reagent 4.
Preferably, the reagent packet 8 is capsule-type reagent packet, and the capsule-type reagent packet includes the film to link together
81, the sealing pond formed between film 81 and the liquid reagent being filled in sealing pond；81 4 side of film described in two panels is equipped with
Edge sealing 82, the edge sealing 82 form closed loop sealing；The section in the sealing pond is trapezoidal, trapezoidal upper bottom edge, bottom and one
A waist edge is equipped with edge sealing 82, and the film 81 uses aluminium film.
In use, the first quantitative 121 quantitative reagent amount of pond in the utility model the first group reagent quantitative reaction system, the
Five quantitative ponds 321 quantify plasma volume, and third quantifies 412 quantitative reagent amount of pond, can dosage needed for accurate quantitative analysis, first quantifies pond
121 Excess reagents amounts flow into the first run-off 122, and third quantifies 412 Excess reagents of pond and flows into third run-off 415, and the 5th
Quantitative pond 321, which quantifies plasma volume and is directly entered reaction tank 6 and then reagent is added, is reacted, after reagent caches in cache pool 5
It enters after reaction tank 6 is reacted and is directly used in detection operation；
The first quantitative 121 quantitative reagent R3 amount of pond in the utility model the second group reagent quantitative reaction system, the 5th is fixed
Amount pond 321 quantify plasma volume, and third quantifies 412 quantitative reagent R4 amount of pond, can dosage needed for accurate quantitative analysis, first quantifies pond
121 Excess reagents R3 amounts flow into the first run-off 122, and third quantifies 412 Excess reagents R4 of pond and flows into third run-off 415,
5th quantitative pond 321, which quantifies plasma volume and is directly entered reaction tank 6 and then reagent R3 is added, is reacted, and reagent R4 is in cache pool 5
It is entered after interior caching after reaction tank 6 is reacted and is directly used in detection operation；
The first quantitative 121 quantitative reagent R5 amount of pond in the utility model third group reagent quantitative reaction system, the 5th is fixed
Amount pond 321 quantify plasma volume, and third quantifies 412 quantitative reagent R6 amount of pond, can dosage needed for accurate quantitative analysis, first quantifies pond
121 Excess reagents R5 amounts flow into the first run-off 122, and third quantifies 412 Excess reagents R6 of pond and flows into third run-off 415,
5th quantitative pond 321, which quantifies plasma volume and is directly entered reaction tank 6 and then reagent R5 is added, is reacted, and reagent R6 is in cache pool 5
It is entered after interior caching after reaction tank 6 is reacted and is directly used in detection operation；What each group reagent quantitative reaction system was added
Reagent is different, and the utility model can carry out the detection of disparity items simultaneously, effectively shorten detection time, especially avoid
The secondary pollution being likely to occur in artificial lock out operation and quantitative error can provide solid guarantor to subsequent detection work
Card.
The utility model needs to cooperate dedicated centrifugally operated equipment, stores needed for each operation of CD in the equipment
The rotation time and velocity of rotation wanted.The centrifugally operated equipment not within the scope of protection of this application, therefore repeats no more.
The CD mentioned in the utility model is made of high molecule plastic, the first reagent 2 and the first quantitative pond 121
It is made Deng using molding, the first diversion pipe 111 and the first conduit 123 etc. are integrated in one using accurate die pressing or etching production
On Zhang Guangpan.
In use, by suitable reagent inject the first reagent 2, centrifugally operated equipment drive CD rotation, reagent from
It is flow in the first quantitative pond 121 under the action of mental and physical efforts by the first diversion pipe 111.The letter of operation is further increased at this
Reagent can be made into packet and be potted directly into the first reagent 2 by just property, CD in production, by reagent to packaging when use
The pressure of bag breaks it automatically.
First diversion pipe 111 connect with the lateral surface in the first quantitative pond 121, under the influence of centrifugal force, reagent by outside and
Interior fills the first quantitative pond 121.After first quantitative pond 121 is filled, extra reagent is transferred to by the first conduit 123
In first run-off 122.The junction of first diversion pipe 111 and the first run-off 122 is closer to cd centre, and such first
The pressure of reagent gradually decreases on the direction for flowing to the first run-off 122 in diversion pipe 111, enables reagent smoothly
Flow into the first run-off 122.Meanwhile first run-off 122 closer to cd centre, the first diversion pipe 111 and can be made
The fluid pressure of one run-off, 122 junction is consistently less than the fluid pressure at the first quantitative pond 121 and the first diversion pipe 111,
Reagent when reagent being avoided to flow out from the first quantitative pond 121 in first run-off 122 also flows out therewith, causes under acquisition precision
Drop.
Reagent from outside to inside during the first quantitative pond 121 is filled, the air in the first quantitative pond 121 is squeezed
It is pressed onto the first run-off 122.With the rotation of CD, bubble that may be present can also be precipitated and be eventually transferred into reagent
In one run-off 122, the bubble in reagent can also be removed simultaneously when carrying out quantitative collection in this way, guarantee acquisition precision.
First quantitative pond 121 is leading flank close to the face of cd centre, is trailing flank far from the face in CD.Leading flank and
Trailing flank is all made of cambered surface design, and center of arc is overlapped with the center of CD, can guarantee reagent in the first quantitative pond 121 in this way
It is inside uniformly distributed, the gas for playing internal is all expressed in the first run-off 122.Design is acquired also for guarantee at this
Precision.
Most narrow spacing of the minimum range of first run-off 122 and cd centre less than the first quantitative pond 121 and cd centre
From can guarantee that the air pressure in quantitative pond 21 is consistently higher than the air pressure in the first run-off 122 in this way, when the first quantitative pond 121
It is not in resistance when interior gas is shifted to the first run-off 122.
Reagent is during entering the first quantitative pond 121, the atmospheric pressure of the first connecting tube 131 and the first quantitative pond 121
Power is greater than the atmospheric pressure of the first conduit 123 and the first quantitative 121 junction of pond.Therefore, it is quantitative to be gradually filled with first for reagent
Pond 121 rather than from the first connecting tube 131 flow out.
Make description below for pressure: the atmospheric pressure in the first connecting tube 131 and the first quantitative pond 121 is by the first fluid stopping
Pipe 132 provides, and the first conduit 123 and the atmospheric pressure of the first quantitative 121 junction of pond are mainly provided by the first conduit 123.The
One connecting tube 131 and the first conduit 123 are connected with the external world, that is, the medium in the two is air, in the work of centrifugal force
Under, pressure is free air lift to supply.Pressure formula P=ρ gh of reference fluids, in the identical situation of ρ and g, the size of pressure is by h
It determines.On the direction close to cd centre, when the first connecting tube 131 is identical with the diameter of the first conduit 123, when the first connection
The length of pipe 131 is greater than the length of the first conduit 123, the atmospheric pressure of the first connecting tube 131 and the first quantitative 121 junction of pond
The atmospheric pressure of the first conduit 123 and the first quantitative 121 junction of pond will be greater than.In actual product, the first connecting tube
131 and first conduit 123 diameter it is close, close to cd centre direction on, the length of the first connecting tube 131 is far longer than
The length of first conduit 123, exactly in order to guarantee existing always for pressure difference at this.
The also external downtake pipe 105 of first run-off 122, the free end of downtake pipe 105 and atmosphere connect
It connects, the air pressure in the first run-off 122 can be made to maintain an equal level always with atmospheric pressure in this way, avoid the first overflow in quantitative collection
Back pressure is generated in pond 122.
After the completion of quantitative, CD is rotated backward, and the reagent in the first quantitative pond 121 has one and CD rotation direction phase
Anti- movement tendency, under the influence of centrifugal force, reagent sequence passes through the first connecting tube 131, the first fluid stopping pipe 132 and first is led
Outlet pipe 133 is transferred in reaction tank 6, carries out subsequent reaction.
CD 1 is mounted on rotating mechanism, drives CD 1 to be rotated under the action of rotating mechanism, it is preferred that CD
1 using circle, and the center of circle of CD 1 is that axle center is rotated.
Since blood plasma is lighter, red blood cell is heavier, under the influence of centrifugal force, in whole blood pond formed Erythrocyte preservation portion with
And blood plasma reservoir, Erythrocyte preservation portion are located at the outside of blood plasma reservoir, since red blood cell accounts for about the 40% of whole blood, limit red
The volumetric ratio of storage of cells portion and blood plasma reservoir is 2:3, and the 5th conduit 513 is connected with blood plasma pond 9, can be effectively ensured from
The discharge of 5th conduit 513 is blood plasma, will not adulterate red blood cell, guarantees accuracy in detection.
The principle that the utility model is combined using centrifugation and quantitative collection can carry out quantitative collection to reagent.It will examination
Agent is filled into the second reagent 4 or reagent is directly built in CD 1 when making CD 1.When CD 1 rotates, examination
Agent is transferred to third under the influence of centrifugal force and quantifies in pond 412, and extra part is transferred in third run-off 415.Transfer
After the completion, CD 1 rotates backward, and third quantifies the reagent in pond 412 and flows out along third conduit C404.Amount of reagent is determined by third
It measures 412 volume of pond to determine, the interference of many factors such as instrumental error, human error, error on line of sight, energy when avoiding artificial quantify
Enough effectively improve quantitative accuracy.
The third run-off of the utility model uses catamaran design, when CD 1 rotates forward, quantifies pond 412 from third
The reagent third of transfer enters pond A413, and under the influence of centrifugal force, reagent is eventually transferred into the B414 of third pond.CD 1 is anti-
To when rotation, the reagent in the B414 of third pond has the movement tendency far from cd centre, but third pond B414 does not have and third
Quantitative pond 412 connects, therefore when third quantify the reagent in pond 412 and flows out, and the reagent in the B414 of third pond remains stationary, can
Guarantee that reagent collection capacity is equal with third amount 412 volumes of pond are determined, to guarantee acquisition precision, final reagent delays in cache pool 5
Enter reaction tank 6 after depositing.
The hydraulic liquid higher than in U-tube 422 and third conduit B423 when CD 1 rotates backward, in third conduit A421
Pressure.Third quantifies in pond 412 reagent during outflow, can only flow out from third conduit C404.Anti-return design is same
Sample can be improved acquisition precision.
The sample of reaction tank 6 after completion of the reaction is directly used in scattering Electronic Speculum, transmission electron microscope, the detection of fluorescence Electronic Speculum.
The reagent that first group of separation reaction system adds is that R1 and R2 is used to detect liver function；Second group of separation reaction system adds
Reagent be R3 and R4, be used to renal function；The reagent that first group of separation reaction system adds is that R5 and R6 is used to detect bone marrow cell.
Finally it should be noted that above embodiments are only to illustrate the technical solution of the utility model, rather than its limitations,
Although the utility model is described in detail with reference to the foregoing embodiments, those skilled in the art should understand that,
It can still modify to technical solution documented by previous embodiment, or be equal to part of technical characteristic
Replacement, and these are modified or replaceed, the utility model embodiment technical solution that it does not separate the essence of the corresponding technical solution
Spirit and scope.
Claims (10)
1. a kind of reagent disc test device for carrying out a variety of diagnosis simultaneously characterized by comprising CD is set on the CD
The reagent quantitative reaction system for being equipped with whole blood separation system and being connected to respectively with whole blood separation system, the reagent quantitative reaction system
No less than 2 groups of system, the reagent quantitative reaction system is uniformly arranged on CD respectively centered on axle center；
The whole blood separation system includes whole blood pond, blood plasma pond, the 5th conduit and the 5th proportioning device；The one of 5th conduit
End is connect with whole blood pond, and the other end is connect with blood plasma pond；5th proportioning device includes the 5th quantitative pond and the 5th quantitative pond
The 5th run-off and the 5th connecting tube of connection；One end of 5th connecting tube is connect with the 5th quantitative pond, the other end and blood
Stock tank connection；
The reagent quantitative reaction system includes the first reagent, the first proportioning device being connected to the first reagent, the second examination
Agent pond, the third proportioning device being connected to the second reagent and the cache pool being connected to third proportioning device, described first is fixed
Amount device, the 5th proportioning device and cache pool are connected to reaction tank respectively.
2. a kind of reagent disc test device for carrying out a variety of diagnosis simultaneously according to claim 1, which is characterized in that described
CD is rotation light transmission circle CD, and the leading flank in the whole blood pond and trailing flank are made of curve, any one curve
The center of curvature be located on the axis of CD；The leading flank in the blood plasma pond and trailing flank are made of curve, any one institute
The center of curvature for stating curve is located on the axis of CD；The center of curvature of the axis of 5th conduit is located at the axis of CD
On；On the direction vertically with CD, there are the curved surfaces that one passes through the 5th conduit axis；Whole blood pond is divided into upper half by the curved surface
Part and lower half portion；The top half is close to the part of CD axis；The volume of the top half and lower half portion
Than for 3:2.
3. a kind of reagent disc test device for carrying out a variety of diagnosis simultaneously according to claim 2, which is characterized in that described
5th run-off is located at the 5th quantitative pond close to the side of cd centre；Described 5th quantitative pond surrounds the axis circle of CD
Column；5th proportioning device further includes the 5th diversion pipe；The both ends of 5th diversion pipe are quantitative with the adjacent the 5th respectively
Pond connection；The center of curvature of 5th diversion pipe is located on the axis of CD.
4. a kind of reagent disc test device for carrying out a variety of diagnosis simultaneously according to claim 3, which is characterized in that whole blood
Separation system further includes aerial drainage pond；The aerial drainage pond is connect with the last one the 5th run-off；One end of 5th connecting tube
It is connect with blood plasma pond；The minimum range of the aerial drainage pond and cd centre is greater than the most narrow spacing of the 5th run-off and cd centre
From.
5. a kind of reagent disc test device for carrying out a variety of diagnosis simultaneously according to claim 4, which is characterized in that described
First proportioning device includes the first quantitative pond and the first run-off, and the rear right side in the described first quantitative pond passes through the first diversion pipe
It being connected to the first reagent, the preceding right side in the described first quantitative pond is connected to the first run-off by the first conduit, and described the
The rear left side in a certain amount of pond is connected to by the first bending tube with reaction tank, is provided with first exhaust at the top of first run-off
Pipe；
First bending tube includes the first connecting tube, is connected to the first connecting tube the first fluid stopping pipe, with the first fluid stopping pipe the
One changeover portion and the first delivery line being connected to First Transition section, the first delivery line connected reaction pond；
The leading flank in the described first quantitative pond is located at being equidistant for each point in sustained height and cd centre；
The minimum range of the First Transition section and the minimum range of cd centre less than the first conduit and cd centre；
Most narrow spacing of the minimum range of first run-off and cd centre less than the first quantitative pond and cd centre.
6. a kind of reagent disc test device for carrying out a variety of diagnosis simultaneously according to claim 5, which is characterized in that described
Third proportioning device includes that third quantifies pond, third run-off and third diversion pipe, and it is quantitative that the third run-off is located at third
Pond is close to the side of cd centre；Second reagent is located at third and quantifies pond close to the side of cd centre；The third
One end of diversion pipe is connected to the second reagent, and the other end quantifies pond with third and is connected to；
The third diversion pipe include third conduit A, with the third conduit A U-tube connecting and the third conduit being connect with U-tube
B；
The other end of the third conduit A is connect with the second reagent；The other end and third of the third conduit B quantifies pond
Input terminal connection；The minimum diameter of the third conduit A is greater than the maximum gauge of U-tube；The minimum diameter of the third conduit A
Greater than the maximum gauge of third conduit B；
The third run-off includes the third pond A and third pond B connecting with third pond A；The third pond B is located at third pond A
Side far from cd centre；The third quantifies pond and connect with third pond A；The third quantifies the connection in pond Yu third pond A
Place is located at third pond A far from the side of cd centre；
Second reagent is equipped with barometric pipe；The other end of the barometric pipe is connected to whole blood pond.
7. a kind of reagent disc test device for carrying out a variety of diagnosis simultaneously according to claim 6, which is characterized in that described
The third conduit C of cache pool connection；The cache pool is located at third and quantifies pond close to the side of cd centre；The third conduit
The other end of C is connect with the input terminal that third quantifies pond；
Surge pipe is additionally provided on the cache pool；The other end of the surge pipe is connected to whole blood pond；It is also set on the cache pool
There is the 4th delivery line, the other end of the 4th delivery line is connected to reaction tank；It is communicated between second reagent and cache pool
Return pipe；
Minimum range between the third conduit C and cd centre is less than the most narrow spacing between the second reagent and cd centre
From.
8. a kind of reagent disc test device for carrying out a variety of diagnosis simultaneously according to claim 7, which is characterized in that described
Two feeding pipes of reaction tank connection, are communicated with exhaust pipe on the reaction tank, and exhaust storehouse is provided on the exhaust pipe；
First delivery line is connected to feeding pipe, and the 4th delivery line and the second ingress pipe are connected to exhaust storehouse respectively；
The inner wall of the reaction tank is in arc transition, and arc length of the reaction tank horizontal cross-section along optical disk rotary direction is hung down greater than it
Directly in the length of direction of rotation, the horizontal cross-section of the reaction tank is oval, the rotation that the short axle of the reaction tank passes through CD
Turn center.
9. a kind of reagent disc test device for carrying out a variety of diagnosis simultaneously according to claim 8, which is characterized in that described
Reagent packet is respectively provided in first reagent and the second reagent.
10. a kind of reagent disc test device for carrying out a variety of diagnosis simultaneously according to claim 9, which is characterized in that institute
State reagent packet be capsule-type reagent packet, the capsule-type reagent packet include formed between the film to link together, film it is close
Envelope pond and the liquid reagent being filled in sealing pond；Three side of film described in two panels is equipped with edge sealing, and the edge sealing forms closed loop sealing；
The section in the sealing pond is that trapezoidal, trapezoidal upper bottom edge, bottom and a waist edge are equipped with edge sealing, and the film is thin using aluminium
Film.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820701609.5U CN208399527U (en) | 2018-05-11 | 2018-05-11 | Reagent disc test device that is a kind of while carrying out a variety of diagnosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201820701609.5U CN208399527U (en) | 2018-05-11 | 2018-05-11 | Reagent disc test device that is a kind of while carrying out a variety of diagnosis |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN208399527U true CN208399527U (en) | 2019-01-18 |
Family
ID=65136146
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
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| CN (1) | CN208399527U (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108828247A (en) * | 2018-05-11 | 2018-11-16 | 石家庄禾柏生物技术股份有限公司 | Reagent disc test device that is a kind of while carrying out a variety of diagnosis |
-
2018
- 2018-05-11 CN CN201820701609.5U patent/CN208399527U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108828247A (en) * | 2018-05-11 | 2018-11-16 | 石家庄禾柏生物技术股份有限公司 | Reagent disc test device that is a kind of while carrying out a variety of diagnosis |
| CN108828247B (en) * | 2018-05-11 | 2024-03-26 | 石家庄禾柏生物技术股份有限公司 | Reagent disk testing device capable of simultaneously carrying out multiple diagnoses |
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