CN217359495U - Blood detection micro-fluidic chip - Google Patents
Blood detection micro-fluidic chip Download PDFInfo
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- CN217359495U CN217359495U CN202121233282.1U CN202121233282U CN217359495U CN 217359495 U CN217359495 U CN 217359495U CN 202121233282 U CN202121233282 U CN 202121233282U CN 217359495 U CN217359495 U CN 217359495U
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Abstract
The utility model discloses a blood detection micro-fluidic chip, which comprises a base plate and a cover plate, wherein the cover plate is matched with the base plate in a sealing way to form a chip body; the chip body is provided with a plurality of separation detection units which take the circle center of the chip body as an original point and are distributed in a radial shape; the separation detection unit comprises a whole blood sample introduction pool, a plasma separation pool, an erythrocyte sedimentation pool, a plasma storage pool, a quantitative pool, a front first-stage waste liquid pool, a front second-stage waste liquid pool, a rear first-stage waste liquid pool, a detection reagent sample introduction pool, a detection pool, and a whole blood sample introduction hole, a whole blood sample introduction pool air hole, a plasma storage pool air hole, a rear first-stage waste liquid pool air hole and a detection reagent sample introduction hole which are arranged on a cover plate. The utility model discloses have separation and detection function simultaneously, can realize that plasma/serum separation, reagent are injected into, reaction and detection integration, solve the blood coagulation and measure and detect the instant detection demand problem that can't satisfy growing.
Description
Technical Field
The utility model relates to a molecular detection and micro-fluidic chip technical field, more specifically the utility model relates to a blood detects micro-fluidic chip that says so.
Background
The human coagulation system is a rather complex system, which includes coagulation factors and anti-coagulation factors, fibrinolytic systems and anti-fibrinolytic systems, etc.
Blood coagulation detection is of great significance for disease prevention, disease treatment and blood transfusion treatment. However, at present, blood coagulation detection still has the problems of blood sample storage, sample extraction and pretreatment, detection efficiency and detection timeliness, and the main limitations thereof are as follows:
1. blood samples are not suitable for long-time storage, and are easy to generate risks of detection index change and degradation along with the lapse of time;
2. blood coagulation detection needs complicated sample extraction and pretreatment processes, and each step needs fixed instruments and consumables, so that the problems of operation errors, sample pollution and the like easily exist, and the detection reliability is influenced;
3. the traditional blood coagulation detection method has the advantages that blood sample separation and detection are separated, each step of treatment needs a certain time, the detection efficiency is low, and timely or batch detection cannot be realized;
4. the traditional blood sample detection requires a large amount of blood samples, but the blood sample collection amount is limited.
Therefore, how to provide a blood detection microfluidic chip integrating separation and detection is an urgent problem to be solved by those skilled in the art.
SUMMERY OF THE UTILITY MODEL
In view of the above, the present invention provides a micro-fluidic chip for blood detection, which at least solves one of the problems mentioned in the background section above.
In order to realize the technical scheme, the utility model discloses a following technical scheme:
a micro-fluidic chip for blood detection comprises a substrate and a cover plate, wherein the cover plate and the substrate are in sealing fit to form a chip body; the chip body is provided with a plurality of separation detection units which are radially distributed by taking the circle center of the chip body as an original point;
the separation detection unit comprises a whole blood sample introduction pool, a plasma separation pool, an erythrocyte sedimentation pool, a plasma storage pool, a quantification pool, a preposed first-stage waste liquid pool, a preposed second-stage waste liquid pool, a postposed first-stage waste liquid pool, a detection reagent sample introduction pool and a detection pool which are arranged on the substrate, and a whole blood sample introduction hole, a whole blood sample introduction pool air hole, a plasma storage pool air hole, a postposed first-stage waste liquid pool air hole and a detection reagent sample introduction hole which are arranged on the cover plate;
the whole blood sample introduction pool is arranged at a position close to the circle center of the chip body, and the whole blood sample introduction pool, the plasma separation pool, the erythrocyte sedimentation pool, the quantification pool and the detection pool are sequentially arranged along a direction far away from the circle center of the chip body; the plasma storage pool is positioned at one side of the erythrocyte sedimentation pool; the prepositive first-stage waste liquid tank and the postpositive first-stage waste liquid tank are respectively positioned at two sides of the quantitative tank; the detection reagent sample introduction pool is positioned on one side of the rear primary waste liquid pool;
the whole blood sampling pool is communicated with the plasma separation pool through a first separation channel, the plasma separation pool is communicated with the red blood cell sedimentation pool through a second separation channel, and the plasma separation pool is communicated with the red blood cell sedimentation pool through a communication channel;
the plasma separation pool is communicated with the plasma storage pool through a siphon channel, and the plasma storage pool is communicated with the preposed first-stage waste liquid pool, the postposition first-stage waste liquid pool and the quantitative pool through liquid separation pipelines; the preposed primary waste liquid pool is communicated with the preposed secondary waste liquid pool through a first circulation channel;
the second flow channel connected with the quantitative pool is intersected with the third flow channel connected with the detection reagent sample injection pool and the fourth flow channel connected with the detection pool, and a micro-fluid valve is arranged at the intersection;
the whole blood sample inlet and the whole blood sample inlet air hole correspond to and are communicated with the whole blood sample inlet; the detection reagent sample inlet hole corresponds to and is communicated with the detection reagent sample inlet pool; the air holes of the postposition primary waste liquid pool correspond to and are communicated with the postposition primary waste liquid pool; the plasma storage pool air holes correspond to and are communicated with the plasma storage pool.
Preferably, in the above-mentioned microfluidic chip for blood detection, the whole blood advances the sample cell the plasma separation pool the erythrocyte sedimentation tank the plasma reservoir the ration pond leading one-level waste liquid pond leading second grade waste liquid pond rearmounted one-level waste liquid pond leading reagent advances the sample cell the detection pond first separation channel the second separation channel intercommunication the passageway the siphon channel divide the liquid pipeline first circulation channel the second circulation channel the third circulation channel the fourth circulation channel is through sculpture or cutting mode the base plate orientation the groove structure that apron one side formed.
Preferably, among the above-mentioned blood detection micro-fluidic chip, whole blood advances the appearance pond and is the crotch form, and whole blood advances the appearance hole with the longer one end in whole blood advances the appearance pond corresponds and communicates, whole blood advances appearance pond bleeder vent with the short one end in whole blood advances the appearance pond corresponds and communicates.
Preferably, in the above blood detection microfluidic chip, a cover plate fixing hole is formed in the center of the cover plate, and a substrate fixing hole is formed in the center of the substrate; the cover plate fixing holes and the substrate fixing holes are identical in shape and are arranged in a superposed mode, and chip fixing holes penetrating through the chip body are formed.
Preferably, in the above microfluidic chip for blood detection, the cover plate and the substrate are made of one of silicon wafer, quartz, glass or polymer compound.
Preferably, in the above microfluidic chip for blood detection, the polymer compound is polymethacrylate, polystyrene, cyclic olefin copolymer or polycarbonate.
Can know via foretell technical scheme, compare with prior art, the utility model discloses a blood detects micro-fluidic chip has separation and detection function simultaneously, can realize plasma serum separation, reagent injection, reaction and detection integration, solves the blood coagulation and measures and can't satisfy growing instantaneous detection demand problem, the utility model discloses a blood detects micro-fluidic chip, need not to carry out any preliminary treatment to blood sample and chip to need not other medicines of embedding or touch device, only rely on the centrifugal action drive to accomplish the blood coagulation and detect, this chip can be used to a plurality of fields such as blood detection, immunodetection, external diagnosis and medical treatment are cosmetic.
Drawings
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required to be used in the description of the embodiments or the prior art will be briefly described below, it is obvious that the drawings in the following description are only embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to the provided drawings without creative efforts.
FIG. 1 is a schematic structural diagram of the present invention;
FIG. 2 is a schematic diagram of a separation detection unit.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only some embodiments of the present invention, not all embodiments. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts all belong to the protection scope of the present invention.
The embodiment of the utility model discloses a blood detection micro-fluidic chip, which comprises a base plate and a cover plate, wherein the cover plate is matched with the base plate in a sealing way to form a chip body 1; the chip body 1 is provided with a plurality of separation detection units 2, and the separation detection units 2 are radially distributed by taking the circle center of the chip body 1 as an original point;
the separation detection unit 2 comprises a whole blood sample introduction pool 3, a plasma separation pool 4, an erythrocyte sedimentation pool 5, a plasma storage pool 6, a quantification pool 7, a preposed first-stage waste liquid pool 8, a preposed second-stage waste liquid pool 9, a postposed first-stage waste liquid pool 10, a detection reagent sample introduction pool 11, a detection pool 12, a whole blood sample introduction hole 13, a whole blood sample introduction pool air hole 14, a plasma storage pool air hole 15, a postposed first-stage waste liquid pool air hole 16 and a detection reagent sample introduction hole 17 which are arranged on a cover plate;
the whole blood sample introduction pool 3 is arranged at a position close to the circle center of the chip body 1, and the whole blood sample introduction pool 3, the plasma separation pool 4, the erythrocyte sedimentation pool 5, the quantification pool 7 and the detection pool 12 are sequentially arranged along a direction far away from the circle center of the chip body 1; the plasma storage tank 6 is positioned at one side of the erythrocyte sedimentation tank 5; the preposed first-stage waste liquid tank 8 and the postpositioned first-stage waste liquid tank 10 are respectively positioned at two sides of the quantitative tank 7; the detection reagent sample introduction pool 11 is positioned on one side of the rear primary waste liquid pool 10;
the whole blood sample feeding pool 3 is communicated with the plasma separation pool 4 through a first separation channel 18, the plasma separation pool 4 is communicated with the erythrocyte sedimentation pool 5 through a second separation channel 19, and the plasma separation pool 4 is communicated with the erythrocyte sedimentation pool 5 through a communication channel 20, so that the effect of fluid communication can be achieved;
the plasma separation tank 4 is communicated with the plasma storage tank 6 through a siphon channel 21, so that the effect of reasonable transfer can be achieved; the plasma storage pool 6 is communicated with the preposed first-stage waste liquid pool 8, the postposition first-stage waste liquid pool 10 and the quantification pool 7 through a liquid separating pipeline 22, and quantification and transfer can be ensured; the prepositive first-stage waste liquid pool 8 is communicated with the prepositive second-stage waste liquid pool 9 through a first flow channel 23;
a second flow channel 24 connected with the quantitative cell 7 is intersected with a third flow channel 25 connected with the detection reagent sample introduction cell 11 and a fourth flow channel 26 connected with the detection cell 12, and a micro-fluid valve 27 is arranged at the intersection to ensure that the detection cell 12 is uniformly mixed and prevent the detection liquid from flowing back;
the whole blood sample inlet 13 and the whole blood sample inlet air hole 14 correspond to and are communicated with the whole blood sample inlet 3, so that fluid circulation and separation can be realized; the detection reagent sample inlet hole 17 corresponds to and is communicated with the detection reagent sample inlet pool 11; the rear primary waste liquid tank air vent 16 corresponds to and is communicated with the rear primary waste liquid tank 10; the air hole 15 of the plasma storage pool is corresponding to and communicated with the plasma storage pool 6.
In order to further optimize the technical scheme, the whole blood sample feeding pool 3, the plasma separation pool 4, the erythrocyte sedimentation pool 5, the plasma storage pool 6, the quantification pool 7, the preposed first-stage waste liquid pool 8, the preposed second-stage waste liquid pool 9, the postposed first-stage waste liquid pool 10, the detection reagent sample feeding pool 11, the detection pool 12, the first separation channel 18, the second separation channel 19, the communication channel 20, the siphon channel 21, the liquid separation pipeline 22, the first circulation channel 23, the second circulation channel 24, the third circulation channel 25 and the fourth circulation channel 26 are groove structures formed on one surface of the substrate facing the cover plate in an etching or cutting mode.
In order to further optimize the technical scheme, the whole blood sample introduction pool 3 is in a hook shape, the whole blood sample introduction hole 13 corresponds to and is communicated with the longer end of the whole blood sample introduction pool 3, and the air hole 14 of the whole blood sample introduction pool corresponds to and is communicated with the shorter end of the whole blood sample introduction pool 3.
In order to further optimize the technical scheme, a cover plate fixing hole is formed in the center of the cover plate, and a base plate fixing hole is formed in the center of the base plate; the cover plate fixing hole is identical to the base plate fixing hole in shape and is overlapped with the base plate fixing hole in shape, a chip fixing hole 28 penetrating through the chip body 1 is formed, the chip fixing hole 28 is used for being installed in a matched mode with centrifugal rotating equipment, the chip is made to rotate, and different plasma samples can be obtained by adjusting the centrifugal force and the centrifugal time.
In order to further optimize the technical scheme, the cover plate and the substrate are made of one of silicon wafers, quartz, glass or high molecular compounds.
In order to further optimize the technical scheme, the high molecular compound is polymethacrylate, polystyrene, cyclic olefin copolymer or polycarbonate.
In order to further optimize the above technical solution, as required, a plurality of detection reagent sample injection cells 11 may be provided, and are respectively communicated with the detection cell 12.
The detection method comprises the following steps:
adding whole blood into a whole blood sample introduction pool 3, and separating the whole blood into two parts of plasma and erythrocyte sediment at a speed of 3000 + 5500r/min for 60-180s clockwise, wherein the plasma enters a plasma separation pool 4, and the erythrocyte sediment enters an erythrocyte sediment pool 5;
then, anticlockwise 500-;
3000-5500r/min for 5-30s, the sample in the preposed primary waste liquid pool 8 enters the preposed secondary waste liquid pool 9, and simultaneously the redundant plasma in the plasma separation pool 4, the siphon channel 21 and the plasma storage pool 6 enters the preposed secondary waste liquid pool 9, so that the quantitative pool 7 is not influenced; adding the detection reagent into the detection reagent sample inlet pool 11, mixing the plasma and the detection reagent in the quantification pool 7 for 2000-3500r/min for 3-10s, and then entering the detection pool 12 for subsequent detection.
When plasma and red blood cells are precipitated, different plasma samples can be obtained by adjusting the centrifugal force, for example, PRP platelet rich plasma can be obtained by 3000 + 3500r/min 60s clockwise, and PPP platelet poor plasma can be obtained by 4500 + 5500r/min 120 + 180s clockwise;
the first separation pipeline and the second separation pipeline have a liquid separation effect under centrifugal driving; the quantitative pool 7 has the function of quantification; the microfluidic valve 27 has the effect of increasing the fluidic resistance.
Platelet aggregation test PRP plasma and PPP plasma in the examples can be used for platelet aggregation test, separated PRP and PPP are centrifuged into detection holes, platelet aggregation inducers, generally more ADP (adenosine diphosphate), are added by a platelet aggregation instrument in a full-automatic manner, and one of ADR (adrenaline), COL (collagen), ARA (arachidonic acid) and RIS (ristocetin) can be used as the inducer.
According to the following steps of an inducer: plasma volume ratio 1: 5-1: 20, preferably 1: 10, adding into the reagent hole. Centrifuging at 3000r/min for 3s, shaking and mixing. Detection was performed on a platelet aggregation meter. The transmittance-time change data was recorded and the maximum platelet aggregation rate was calculated. The processing of the measured data is well-established and will not be described in detail here.
The utility model discloses the superiority as follows:
1. the utility model provides a micro-fluidic chip blood separation and detection chip collection separation and detection are as an organic whole, can realize one-step method separation and detection, and the chip need not any pretreatment, need not other medicines of embedding or touch device, only lean on the centrifugal action drive to accomplish the blood coagulation and detect, easy operation, efficient, the good reliability.
2. The utility model discloses what well chip design was innovated has contained siphon passageway 21, waste liquid pond, separation channel, ration pond 7 and circulation valve, plays effective transfer, detects the ration, prevents the effect of suck-back, increases and detects the precision.
3. The utility model provides a loaded down with trivial details sample extraction and pretreatment process in the traditional detection, avoided operational error, sample pollution reliability problem brought effectively.
4. The utility model discloses well chip accessible is adjusted centrifugal rate and is prepared different plasma samples, for example PRP, PPP etc. simple, swift, practical.
5. The utility model discloses in solved traditional blood sample and drawn and utilized limited problem, practiced thrift the sample quantity, improved sample utilization.
The embodiments in the present description are described in a progressive manner, each embodiment focuses on differences from other embodiments, and the same and similar parts among the embodiments are referred to each other. The device disclosed by the embodiment corresponds to the method disclosed by the embodiment, so that the description is simple, and the relevant points can be referred to the method part for description.
The previous description of the disclosed embodiments is provided to enable any person skilled in the art to make or use the present invention. Various modifications to these embodiments will be readily apparent to those skilled in the art, and the generic principles defined herein may be applied to other embodiments without departing from the spirit or scope of the invention. Thus, the present invention is not intended to be limited to the embodiments shown herein but is to be accorded the widest scope consistent with the principles and novel features disclosed herein.
Claims (6)
1. The microfluidic chip for blood detection is characterized by comprising a substrate and a cover plate, wherein the cover plate and the substrate are in sealing fit to form a chip body; the chip body is provided with a plurality of separation detection units which take the circle center of the chip body as an original point and are distributed in a radial shape;
the separation detection unit comprises a whole blood sample introduction pool, a plasma separation pool, an erythrocyte sedimentation pool, a plasma storage pool, a quantification pool, a preposed first-stage waste liquid pool, a preposed second-stage waste liquid pool, a postposed first-stage waste liquid pool, a detection reagent sample introduction pool and a detection pool which are arranged on the substrate, and a whole blood sample introduction hole, a whole blood sample introduction pool air hole, a plasma storage pool air hole, a postposed first-stage waste liquid pool air hole and a detection reagent sample introduction hole which are arranged on the cover plate;
the whole blood sample introduction pool is arranged at a position close to the circle center of the chip body, and the whole blood sample introduction pool, the plasma separation pool, the red blood cell sedimentation pool, the quantification pool and the detection pool are sequentially arranged along a direction far away from the circle center of the chip body; the plasma storage pool is positioned at one side of the erythrocyte sedimentation pool; the prepositive first-stage waste liquid tank and the postpositive first-stage waste liquid tank are respectively positioned at two sides of the quantitative tank; the detection reagent sample introduction pool is positioned on one side of the rear primary waste liquid pool;
the whole blood sampling pool is communicated with the plasma separation pool through a first separation channel, the plasma separation pool is communicated with the red blood cell sedimentation pool through a second separation channel, and the plasma separation pool is communicated with the red blood cell sedimentation pool through a communication channel;
the plasma separation pool is communicated with the plasma storage pool through a siphon channel, and the plasma storage pool is communicated with the preposed first-stage waste liquid pool, the postposition first-stage waste liquid pool and the quantitative pool through liquid separation pipelines; the preposed primary waste liquid pool is communicated with the preposed secondary waste liquid pool through a first circulation channel;
the second flow channel connected with the quantitative pool is intersected with the third flow channel connected with the detection reagent sample injection pool and the fourth flow channel connected with the detection pool, and a micro-fluid valve is arranged at the intersection;
the whole blood sample inlet and the whole blood sample inlet air hole correspond to and are communicated with the whole blood sample inlet; the detection reagent sample inlet hole corresponds to and is communicated with the detection reagent sample inlet pool; the air holes of the postposition primary waste liquid pool correspond to and are communicated with the postposition primary waste liquid pool; the plasma storage pool air holes correspond to and are communicated with the plasma storage pool.
2. The microfluidic chip for blood detection according to claim 1, wherein the whole blood sample injection pool, the plasma separation pool, the erythrocyte sedimentation pool, the plasma storage pool, the quantification pool, the pre-primary waste liquid pool, the pre-secondary waste liquid pool, the post-primary waste liquid pool, the detection reagent sample injection pool, the detection pool, the first separation channel, the second separation channel, the communication channel, the siphon channel, the liquid separation pipeline, the first circulation channel, the second circulation channel, the third circulation channel, and the fourth circulation channel are all groove structures.
3. The microfluidic chip for blood detection according to claim 1, wherein the whole blood sampling pool is hook-shaped, the whole blood sampling hole corresponds to and communicates with the longer end of the whole blood sampling pool, and the air vent of the whole blood sampling pool corresponds to and communicates with the shorter end of the whole blood sampling pool.
4. The microfluidic chip for blood detection according to claim 1, wherein the center of the cover plate is provided with a cover plate fixing hole, and the center of the substrate is provided with a substrate fixing hole; the cover plate fixing holes and the substrate fixing holes are identical in shape and are arranged in a superposed mode, and chip fixing holes penetrating through the chip body are formed.
5. The microfluidic chip for blood detection according to claim 1, wherein the cover plate and the substrate are made of one of silicon wafer, quartz, glass and polymer.
6. The microfluidic chip for blood detection according to claim 5, wherein the polymer compound is polymethacrylate, polystyrene, cyclic olefin copolymer or polycarbonate.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202121233282.1U CN217359495U (en) | 2021-06-03 | 2021-06-03 | Blood detection micro-fluidic chip |
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| Application Number | Priority Date | Filing Date | Title |
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| CN202121233282.1U CN217359495U (en) | 2021-06-03 | 2021-06-03 | Blood detection micro-fluidic chip |
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| CN217359495U true CN217359495U (en) | 2022-09-02 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116559449A (en) * | 2023-07-10 | 2023-08-08 | 浙江盛域医疗技术有限公司 | Platelet and coagulation microfluidic detection chip with rear quantification |
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2021
- 2021-06-03 CN CN202121233282.1U patent/CN217359495U/en active Active
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116559449A (en) * | 2023-07-10 | 2023-08-08 | 浙江盛域医疗技术有限公司 | Platelet and coagulation microfluidic detection chip with rear quantification |
| CN116559449B (en) * | 2023-07-10 | 2023-10-31 | 浙江盛域医疗技术有限公司 | Platelet and coagulation microfluidic detection chip with rear quantification |
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