CN213761867U - Centrifugal urine routine detection micro-fluidic chip - Google Patents
Centrifugal urine routine detection micro-fluidic chip Download PDFInfo
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- CN213761867U CN213761867U CN202022273877.1U CN202022273877U CN213761867U CN 213761867 U CN213761867 U CN 213761867U CN 202022273877 U CN202022273877 U CN 202022273877U CN 213761867 U CN213761867 U CN 213761867U
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Abstract
The utility model discloses a centrifugal urine conventional detection micro-fluidic chip relates to urine conventional examination, and it is loaded down with trivial details to have solved the process that exists in the current urine conventional examination process, leads to the beneath problem of work efficiency, and its technical scheme main points are: the liquid storage device comprises a main body substrate, wherein inner cavity channels are uniformly arranged in the main body substrate, each inner cavity channel is not communicated, each inner cavity channel consists of a liquid inlet channel, a liquid storage bin, a main channel and a liquid distribution bin, a central through hole is formed in the center of the main body substrate, positioning guide holes are symmetrically formed in the peripheral outer edge of the main body substrate, a protective membrane is connected to the upper surface of the main body substrate, the lower surface of the protective membrane is in contact with the upper surface of the main body substrate, and the cross sectional area of the liquid storage bin is larger than that of the main channel; the batch-type detection operation can be simultaneously carried out, and the problem that the sample is polluted can be effectively avoided in the detection process.
Description
Technical Field
The utility model relates to a urine conventional examination, more specifically says that it relates to a centrifugal urine conventional detection micro-fluidic chip.
Background
Urine routine is one of three clinical routine tests, and as an excrement test, the urine reflects the metabolic condition of the body and is an important index for diagnosing many diseases. For example, proteinuria or urinary sediment can appear in early stage of uremia, urine parameter variation is often a sign of kidney or urinary tract diseases, and routine examination contents of urine comprise color, transparency, pH value, red blood cells, white blood cells, epithelial cells, casts, protein, specific gravity and urine sugar of urine, so that the diagnosis of opportunistic infection is realized, because the pathological characteristics of AIDS are mainly the reduction of human immunity, the AIDS is very easy to be infected, various diseases are induced, such as kidney or urinary tract diseases, therefore, the routine urine examination can also be used as one of the aids examination means, and in the routine urine examination process, samples need to be sampled in batches for analysis, the process is complicated, a large amount of time is consumed, the working efficiency of inspectors is not high, therefore, to solve such problems, we propose a centrifugal urine conventional detection microfluidic chip.
SUMMERY OF THE UTILITY MODEL
The utility model aims at providing a centrifugal urine conventional detection micro-fluidic chip can carry out batch formula's detection operation simultaneously, in the testing process, can effectively avoid the sample to receive the problem of pollution.
The above technical purpose of the present invention can be achieved by the following technical solutions: including the main part base plate, the main part base plate is inside to be and evenly to be provided with the inner chamber way, every the inner chamber way does not communicate, just the inner chamber way comprises feed liquor runner, storage liquid storehouse, sprue and branch liquid storehouse.
Through adopting above-mentioned technical scheme, overall structure divide into the inner chamber of multiunit and says, in the testing process, mainly says at solitary inner chamber that the inside reaction is detected, and mutual noninterference in every reaction sequence, so can carry out the testing and analyzing simultaneously for detect speed reduces the detection step, thereby improves work efficiency.
The utility model discloses further set up to: the center position of the main body substrate is provided with a center through hole, and the circumferential outer edge of the main body substrate is symmetrically provided with positioning guide holes.
Through adopting above-mentioned technical scheme, below the situation that cooperation centrifuge used, the center through-hole that sets up matches with the spud on the centrifuge, and the positioning guide arm of setting can play the effect of stabilizing the main part base plate.
The utility model discloses further set up to: the upper surface of the main body substrate is connected with a protective membrane, and the lower surface of the protective membrane is in contact with the upper surface of the main body substrate.
Through adopting above-mentioned technical scheme, at the in-process that detects, in order to prevent that the sample from overflowing, lead to the sample of each inner chamber way inside on the main part base plate to receive the pollution, so be provided with the protection diaphragm, play the effect of protection sample.
The utility model discloses further set up to: the cross-sectional area of the liquid storage bin is larger than that of the main runner, a sample adding hole is formed in the initial end of the liquid inlet runner, and the upper end of the sample adding hole penetrates through the upper surface of the main body substrate.
Through adopting above-mentioned technical scheme, in centrifugal process, deposit the inside storage sample in the liquid storehouse, under the prerequisite that cooperation centrifuge used, can guarantee to deposit the inside sample of liquid storehouse and satisfy the reaction demand after.
The utility model discloses further set up to: an S-shaped flow limiting channel is arranged in the middle of the main flow channel and is positioned at the rear end of the liquid distribution bin.
By adopting the technical scheme, in the centrifugal process, the sample is gradually diffused into the reaction bin under the action of centrifugal force, the set S-shaped flow limiting channel can increase the flow speed of the sample, prolong the reaction time and improve the accuracy of detection data.
The utility model discloses further set up to: the liquid distribution chamber is evenly provided with sub-channels, each sub-channel is connected with a reaction chamber, the reaction chamber is provided with a dosing hole, the reaction chamber is connected with a liquid outlet channel, the tail end of the liquid outlet channel is provided with an exhaust hole, and the upper ends of the exhaust hole and the dosing hole penetrate through the upper surface of the main body substrate.
Through adopting above-mentioned technical scheme, in the testing process in batches, also can carry out the detection reaction of batching again to solitary sample testing process, through adding the medicament in adding the medicine hole, can carry out the operation of the detection and analysis of different parameters simultaneously.
The utility model discloses further set up to: each branch runner is provided with a flow blocking runner.
Through adopting above-mentioned technical scheme, in the testing process, prevent that the inside sample of each reaction storehouse from circulating each other, cause whole sample to receive the pollution, influence the testing data.
The utility model discloses further set up to: the setting depth of the liquid storage bin in the vertical direction is greater than that of the main runner.
Through adopting above-mentioned technical scheme, at the in-process that adds the sample, because the depth of setting up of depositing the liquid storehouse is greater than the depth of setting up of sprue, so can avoid appearing the siphon phenomenon, cause the sample to spill over the problem of polluting the main part base plate.
To sum up, the utility model discloses following beneficial effect has: in the use, can reduce the detection step for detection efficiency, every group testing process mutually noninterfere detects the data rate of accuracy height, and can play the effect that the protection sample avoids receiving the pollution, simple to use.
Drawings
In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the drawings required for the embodiments or the prior art descriptions will be briefly described below, and it is obvious that the drawings in the following description are only some embodiments of the present invention, and it is obvious for those skilled in the art to obtain other drawings without creative efforts.
FIG. 1 is a subjective view of the line of the invention;
fig. 2 is a schematic structural diagram of the present invention;
fig. 3 is a transverse sectional view of the present invention.
In the figure: 1. a main body substrate; 2. positioning the guide hole; 3. a protective membrane; 4. a sample application hole; 5. a central through hole; 6. a liquid inlet flow channel; 7. a liquid storage bin; 8. an S-shaped flow limiting channel; 9. a main flow channel; 10. a liquid separation bin; 11. a shunt channel; 12. a reaction bin; 13. a medicine adding hole; 14. blocking a flow channel; 15. an exhaust hole; 16. and a liquid outlet flow passage.
Detailed Description
In order to make the technical problems, technical solutions and advantageous effects to be solved by the present invention more clearly understood, the present invention is further described in detail below with reference to the accompanying drawings 1 to 3 and the embodiments.
It will be understood that when an element is referred to as being "secured to" or "disposed on" another element, it can be directly on the other element or be indirectly on the other element. When an element is referred to as being "connected to" another element, it can be directly or indirectly connected to the other element.
It will be understood that the terms "length," "width," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like are used in an orientation or positional relationship indicated in the drawings for convenience in describing the invention and to simplify the description, and are not intended to indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and are therefore not to be considered limiting of the invention.
Furthermore, the terms "first", "second" and "first" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of that feature. In the description of the present invention, "a plurality" means two or more unless specifically limited otherwise.
Example (b): a centrifugal urine routine detection micro-fluidic chip comprises a main body substrate 1, wherein inner cavity channels are uniformly arranged in the main body substrate 1, each inner cavity channel is not communicated, and each inner cavity channel is composed of a liquid inlet channel 6, a liquid storage bin 7, a main channel 9 and a liquid separation bin 10.
As shown in fig. 1 and 2, a central through hole 5 is formed in the center of the main substrate 1, positioning guide holes 2 are symmetrically formed in the peripheral edge of the main substrate 1, a protective film 3 is connected to the upper surface of the main substrate 1, and the lower surface of the protective film 3 contacts with the upper surface of the main substrate 1.
As shown in fig. 3, the cross-sectional area of the liquid storage bin 7 is larger than that of the main flow channel 9, the sample adding hole 4 is formed at the initial end of the liquid inlet flow channel 6, the upper end of the sample adding hole 4 penetrates through the upper surface of the main body substrate 1, and the setting depth of the liquid storage bin 7 in the vertical direction is larger than that of the main flow channel 9.
As shown in fig. 3, the middle position of the main flow channel 9 is provided with an S-shaped flow limiting channel 8, the S-shaped flow limiting channel 8 is located at the rear end of the liquid distribution chamber 10, the liquid distribution chamber 10 is uniformly provided with branch flow channels 11, each branch flow channel 11 is connected with a reaction chamber 12, the reaction chamber 12 is provided with a dosing hole 13, the reaction chamber 12 is connected with a liquid outlet flow channel 16, the tail end of the liquid outlet flow channel 16 is provided with an exhaust hole 15, the upper ends of the exhaust hole 15 and the dosing hole 13 penetrate through the upper surface of the main substrate 1, and each branch flow channel 11 is provided with a flow blocking channel 14.
The working principle is as follows: in the using process, the protective membrane 3 is firstly lifted, and then according to the detection requirement, an independent reaction detection process can be carried out on one inner cavity channel, or independent reaction operation processes can be simultaneously carried out on a plurality of inner cavity channels;
in the detection process, a sample to be detected is added into the sample adding hole 4 at the corresponding position, the sample slowly enters the liquid storage bin 7 through the liquid inlet flow channel 6, the cross sectional area and the setting depth of the liquid storage bin 7 are both larger than those of the main flow channel 9, so that the siphonage phenomenon can be prevented from occurring, the sample overflows to pollute the upper surface of the main body substrate 1, and on the other hand, the sample stored in the liquid storage bin 7 can meet the requirements of each reaction bin 12;
then, according to the detection requirement, a detection medicament can be injected into the reaction bin 12 at the corresponding position through the medicament feeding hole 13;
finally, attaching the protective membrane 3 on the main body substrate 1, placing the main body substrate 1 on a centrifuge along the central through hole 5, and enabling the main body substrate 1 to be in a relatively stable state through the positioning guide hole 2;
in the centrifugal process, the sample in each liquid storage bin 7 firstly enters the liquid separation bin 10 through the S-shaped flow channel 8 along the main flow channel 9, then sequentially enters the reaction bins 12 through the branch flow channels 11 to react with the reagent, and because the branch flow channels 11 are provided with the blocking bins 14, the sample and the reagent in the reaction bins 12 can be prevented from flowing back to cause the pollution of the whole sample,
the present embodiment is only for explaining the present invention, and it is not limited to the present invention, and those skilled in the art can make modifications to the present embodiment without inventive contribution as required after reading the present specification, but all of them are protected by patent laws within the scope of the claims of the present invention.
Claims (8)
1. A centrifugal urine routine detection micro-fluidic chip comprises a main body substrate (1), and is characterized in that: the main part base plate (1) is inside to be evenly provided with the inner chamber way, every the inner chamber way does not communicate, just the inner chamber way comprises feed liquor runner (6), deposit liquid storehouse (7), sprue (9) and branch liquid storehouse (10).
2. A centrifugal urine routine testing microfluidic chip as claimed in claim 1, wherein: the center position of main part base plate (1) has seted up central through-hole (5), just the circumference outer fringe of main part base plate (1) is the symmetry and has seted up location guide hole (2).
3. A centrifugal urine routine testing microfluidic chip as claimed in claim 1, wherein: the upper surface of main part base plate (1) is connected with protection diaphragm (3), the lower surface of protection diaphragm (3) and the upper surface contact of main part base plate (1).
4. A centrifugal urine routine testing microfluidic chip as claimed in claim 1, wherein: the cross-sectional area of depositing liquid storehouse (7) is greater than the cross-sectional area of sprue (9), sample hole (4) have been seted up to the initial end of feed liquor runner (6), the upper surface of main part base plate (1) is run through to the upper end of sample hole (4).
5. A centrifugal urine routine testing microfluidic chip as claimed in claim 1, wherein: an S-shaped flow limiting channel (8) is arranged in the middle of the main channel (9), and the S-shaped flow limiting channel (8) is located at the rear end of the liquid distribution bin (10).
6. A centrifugal urine routine testing microfluidic chip as claimed in claim 1, wherein: divide and evenly seted up subchannel (11) on liquid storehouse (10), every all be connected with reaction storehouse (12) on subchannel (11), reaction storehouse (12) have been seted up and have been added medicine hole (13), just be connected with out liquid flow way (16) on reaction storehouse (12), go out the end of liquid flow way (16) and seted up exhaust hole (15), the upper end of exhaust hole (15) and adding medicine hole (13) all runs through the upper surface of main part base plate (1).
7. The microfluidic chip for centrifugal urine routine testing according to claim 6, wherein: each branch runner (11) is provided with a flow blocking runner (14).
8. A centrifugal urine routine testing microfluidic chip as claimed in claim 1, wherein: the setting depth of the liquid storage bin (7) in the vertical direction is greater than that of the main runner (9).
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| CN202022273877.1U CN213761867U (en) | 2020-10-13 | 2020-10-13 | Centrifugal urine routine detection micro-fluidic chip |
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| CN202022273877.1U CN213761867U (en) | 2020-10-13 | 2020-10-13 | Centrifugal urine routine detection micro-fluidic chip |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN114181825A (en) * | 2021-11-29 | 2022-03-15 | 南昌大学 | Cell transfection system for microfluidic centrifugal extrusion under action of external electric field |
| CN116515617A (en) * | 2023-07-03 | 2023-08-01 | 杭州杰毅生物技术有限公司 | Centrifugal PCR-fluorescence multi-target detection chip |
| CN116622493A (en) * | 2023-07-26 | 2023-08-22 | 成都云芯医联科技有限公司 | Microfluidic blood cell detection chip |
| CN117233412A (en) * | 2023-11-13 | 2023-12-15 | 成都斯马特科技有限公司 | Microfluidic biochemical reagent disk and biochemical inspection and analysis method |
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2020
- 2020-10-13 CN CN202022273877.1U patent/CN213761867U/en active Active
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114181825A (en) * | 2021-11-29 | 2022-03-15 | 南昌大学 | Cell transfection system for microfluidic centrifugal extrusion under action of external electric field |
| CN114181825B (en) * | 2021-11-29 | 2024-05-03 | 南昌大学 | Microfluidic centrifugal extrusion cell transfection system under action of external electric field |
| CN116515617A (en) * | 2023-07-03 | 2023-08-01 | 杭州杰毅生物技术有限公司 | Centrifugal PCR-fluorescence multi-target detection chip |
| CN116515617B (en) * | 2023-07-03 | 2023-10-20 | 杭州杰毅生物技术有限公司 | Centrifugal PCR-fluorescence multi-target detection chip |
| CN116622493A (en) * | 2023-07-26 | 2023-08-22 | 成都云芯医联科技有限公司 | Microfluidic blood cell detection chip |
| CN116622493B (en) * | 2023-07-26 | 2023-09-26 | 成都云芯医联科技有限公司 | Microfluidic blood cell detection chip |
| CN117233412A (en) * | 2023-11-13 | 2023-12-15 | 成都斯马特科技有限公司 | Microfluidic biochemical reagent disk and biochemical inspection and analysis method |
| CN117233412B (en) * | 2023-11-13 | 2024-02-02 | 成都斯马特科技有限公司 | Microfluidic biochemical reagent disk and biochemical inspection and analysis method |
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