CN210775506U - Blood sample test chip device - Google Patents
Blood sample test chip device Download PDFInfo
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- CN210775506U CN210775506U CN201920997120.1U CN201920997120U CN210775506U CN 210775506 U CN210775506 U CN 210775506U CN 201920997120 U CN201920997120 U CN 201920997120U CN 210775506 U CN210775506 U CN 210775506U
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- hole
- blood sample
- chip device
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- flow channel
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
Abstract
The utility model discloses a blood sample test chip device, including main part, sample hole, be used for covering the first apron of the first face of main part, be used for covering the second apron of main part second face, be provided with incubation zone, runner, transfer pond, reaction chamber, valve hole in the first face, the sample hole passes through runner and incubation zone intercommunication, the reaction chamber pass through the runner with transfer pond intercommunication. It integrates a plurality of treatments such as subpackage, sample reaction and the like, provides a quick and easy-to-use sample testing device, and avoids various pretreatment operations in a liquid transfer workstation.
Description
Technical Field
The utility model relates to the field of medical equipment, concretely relates to blood sample test chip device.
Background
Blood is one of the most readily available and most effective samples for monitoring the condition of the body in medical testing, and is the most common sample in medical testing. The development of many modern fully automatic analyzers is also developed based on the detection of blood samples, such as chemiluminescence immune analyzers, fully automatic biochemical analyzers and the like, and the quality of on-machine pretreatment of blood samples undoubtedly plays a crucial role in the detection of results.
In the prior art, before a blood sample is tested, sample pretreatment needs to be carried out in a pipetting workstation, wherein the sample pretreatment comprises a series of operations such as mixing, extraction, PCR amplification, fluorescence reaction and the like, the process is complex, and other interference factors are easy to introduce.
SUMMERY OF THE UTILITY MODEL
In order to solve the technical problem, the utility model provides a blood sample test chip device, it adopts micro-fluidic technology to carry out partial shipment, sample reaction to sample and incubation sample, collects multiple processing in an organic whole, provides the device of a quick easy-to-use for clinician and laboratory staff and tests the liquid sample in hospital, doctor's office, laboratory environment, provides accurate test data.
It should be noted that the sample testing chip device provided by the present invention can be used not only for testing blood samples, but also for any other liquid samples.
The utility model discloses the technical scheme who adopts does:
a blood sample test chip device comprises a main body, wherein a sample hole used for receiving a blood sample is arranged on one side of the main body, the sample hole is communicated with the main body, a first flow channel with one end communicated with the sample hole is arranged on a first surface of the main body, the other end of the first flow channel is communicated with an incubation zone, the bottom of the incubation zone is communicated with one end of a second flow channel, the other end of the second flow channel is provided with a second small hole, the second small hole is opened to a second surface of the main body, a third flow channel is arranged on the second surface, one end of the third flow channel is a second small hole, the other end of the third flow channel is provided with a third small hole communicated with the first surface, the third small hole is positioned in a transfer pool on the first surface, one or more fourth small holes opened to the second surface are additionally arranged in the transfer pool, one or more fourth flow channels are arranged on the second surface, the one end of fourth runner is the fourth aperture, the other end of fourth runner is for leading to the fifth aperture of first face, still be provided with on the first face with the fourth and one or more reaction chamber that the fifth aperture corresponds, the fifth aperture set up in the reaction chamber, still be provided with the valve hole that is used for taking out the negative pressure on the first face, first face is equipped with and is used for laminating completely and covers its regional first apron, the second face is equipped with and is used for laminating completely and covers its regional second apron.
In one technical scheme, the bottom of the sample hole is communicated with the main body through a first small hole.
As an improvement to the above technical scheme, a needle is fixedly arranged at the bottom of the sample hole and communicated with the main body.
In order to enable gentle infusion of the blood sample, the fifth well is provided at the bottom side of the reaction chamber.
As an improvement to the above technical solution, in order to be able to discharge waste liquid, a waste liquid hole is further provided on the top side of the reaction chamber, and one or more waste liquid regions communicating with the waste liquid hole are further provided on the first face.
As an improvement to the above technical scheme, a freeze-drying reactant is arranged in the reaction cavity.
Preferably, four fourth small holes are arranged in the transfer pool, correspondingly, four fourth flow channels, four fifth small holes and four reaction cavities are arranged in the transfer pool, and the reaction cavities are communicated with the transfer pool through the fourth flow channels respectively.
Further preferably, the path lengths of the four fourth flow channels are identical.
In order to promote the reaction, a mixing ball is also arranged in the reaction cavity.
When testing the blood sample, the tester only needs to insert the collected blood sample into the sample hole of the device, negative pressure is pumped into the device through the valve hole, so that the sample reaches the incubation zone through the runner, the previous incubation of the mixed pattern can be carried out by using an auxiliary tool in the incubation zone, then the negative pressure is continuously pumped through the valve hole by rotating the runner, the sample enters the reaction cavity through the runner, the freeze-drying reaction is carried out through the freeze-drying reactant in the reaction cavity, and the full reaction is ensured by the action of the chromium-plated metal ball.
Adopt the utility model discloses a test chip device, the use of test method and light wave is not restricted, can adopt the wavelength to be 100nm-650 nm's light wave, is applicable to absorbance (Abs), Fluorescence Intensity (FI), time-resolved fluorescence (TRF), Fluorescence Polarization (FP) and chemiluminescence (Lum)'s structure.
The utility model has the advantages that: the utility model discloses a blood sample test chip device adopts micro-fluidic technology to carry out partial shipment, sample reaction to sample and incubation sample, collects multiple processing in an organic whole, provides the device of a quick easy-to-use for clinician and laboratory staff and tests the liquid sample in hospital, doctor's office, laboratory environment, provides accurate test data, avoids the various pretreatment operations of going on in moving liquid workstation.
Drawings
Fig. 1 is a view of a first side with a first cover plate removed according to an embodiment of the present invention;
fig. 2 is a view of the second face with the second cover plate removed according to an embodiment of the present invention.
Detailed Description
The present invention is further described with reference to the following drawings and specific embodiments so that those skilled in the art can better understand the present invention and can implement the present invention, but the embodiments are not to be construed as limiting the present invention.
Referring to fig. 1 and 2, an embodiment of a blood sample testing chip device according to the present invention includes a main body 1, a sample hole 2 for receiving a blood sample is disposed on one side of the main body 1, the sample hole 2 is communicated with the main body 1, in a preferred embodiment, the bottom of the sample hole 2 is communicated with the main body 1 by disposing a first small hole (not shown), in a further preferred embodiment, a needle 21 is fixedly disposed at the bottom of the sample hole 2, and the needle 21 is communicated with the main body 1 by the first small hole. On the first surface of the main body 1, as shown in fig. 1, a first flow channel 31 having one end communicating with the sample well 2 is provided, the other end of the first flow channel 31 is connected to the incubation zone 4, the bottom of the incubation zone 4 is connected to one end of a second flow channel 32, the other end of the second flow channel 32 is provided with a second small hole 52, the second small hole 52 opens to the second surface of the main body, the second surface is provided with a third flow channel 33, one end of the third flow channel 33 is provided with the second small hole 52, the other end of the third flow channel 33 is provided with a third small hole 53 opening to the first surface, the third small hole 53 is located in a transit pool 6 on the first surface, the transit pool 6 is further provided with one or more fourth small holes 54 opening to the second surface, the second surface is provided with one or more fourth flow channels 34, one end of the fourth flow channel 34 is provided with a fourth small hole 54, the other end of the fourth flow channel 34 is a fifth small hole 55 leading to the first surface, the first surface is further provided with one or more reaction chambers 7 corresponding to the fourth small hole 54 and the fifth small hole 55, the fifth small hole 55 is arranged in the reaction chamber 7, in order to allow the blood sample to be injected gently, the fifth small hole 55 is arranged at the bottom side of the reaction chamber 7, the first surface is further provided with a valve hole 8 for pumping negative pressure, the first surface is provided with a first cover plate 91 for completely covering the area of the first small hole in a fitting manner, and the second surface is provided with a second cover plate 92 for completely covering the area of the first small hole in a fitting manner.
In a preferred embodiment, in order to be able to discharge reaction waste, the top side of the reaction chamber 7 is further provided with waste holes 71, and the first face is further provided with one or more waste zones 72 communicating with the waste holes 71.
In a preferred embodiment, a lyophilized reagent is provided in the reaction chamber 7.
In the preferred embodiment shown in fig. 1 and 2, four fourth small holes 54 are provided in the transfer pool 6, correspondingly, four fourth flow channels 34, four fifth small holes 55 and four reaction chambers 7 are provided, and the reaction chambers 7 are respectively communicated with the transfer pool 6 through the fourth flow channels 34.
In order to ensure that the reaction chambers 7 receive the same amount of blood sample at the same time, in a preferred embodiment, the four fourth flow channels 34 have exactly the same path length and size.
In order to promote the reaction, a mixing ball is also arranged in the reaction chamber 7, and in a preferred embodiment, the mixing ball is a chrome-plated metal ball.
When testing the blood sample, the tester only needs to insert the collected blood sample into the sample hole 2 of the device, and pump negative pressure into the device through the valve hole 8, at this time, the sample reaches the incubation zone 4 through the first flow channel 31, the incubation zone 4 can be used for the previous incubation in a mixed mode by an auxiliary tool, then the negative pressure is continuously pumped through the valve hole 8, the sample enters the second flow channel 32 from the incubation zone 4, enters the third flow channel 33 on the second surface of the device through the second small hole 52, then enters the transfer pool 6 on the first surface of the device through the third small hole 53 in the third flow channel 33, then enters the fourth flow channel 34 through the fourth small hole 54 in the transfer pool 6, finally enters the reaction chamber 7 through the fifth small hole 55 in the fourth flow channel 34, the freeze-drying reaction is carried out through the freeze-drying reactant in the reaction chamber 7, the chrome-plated metal ball has the function of ensuring the full reaction, the waste liquid of the reaction can be discharged into the waste liquid chamber 72 through the waste liquid hole 71 in the reaction chamber 7, and the position of the waste liquid chamber 72 can be set one or more according to the available space on the apparatus.
Adopt the utility model discloses a test chip device, the use of test method and light wave is not restricted, can adopt the wavelength to be 100nm-650 nm's light wave, is applicable to absorbance (Abs), Fluorescence Intensity (FI), time-resolved fluorescence (TRF), Fluorescence Polarization (FP) and chemiluminescence (Lum)'s structure.
The above-mentioned embodiments are merely preferred embodiments for fully illustrating the present invention, and the scope of the present invention is not limited thereto. Equivalent substitutes or changes made by the technical personnel in the technical field on the basis of the utility model are all within the protection scope of the utility model. The protection scope of the present invention is subject to the claims.
Claims (9)
1. A blood sample test chip device, includes the main part, its characterized in that: a sample hole for receiving a blood sample is arranged on one side of the main body, the sample hole is communicated with the main body, a first flow channel with one end communicated with the sample hole is arranged on the first surface of the main body, the other end of the first flow channel is communicated with an incubation zone, the bottom of the incubation zone is communicated with one end of a second flow channel, a second small hole is formed in the other end of the second flow channel, the second small hole is opened to the second surface of the main body, a third flow channel is arranged on the second surface, one end of the third flow channel is a second small hole, the other end of the third flow channel is provided with a third small hole communicated with the first surface, the third small hole is positioned in a transit pool on the first surface, one or more fourth small holes opened to the second surface are additionally arranged in the transit pool, one or more fourth flow channels are arranged on the second surface, the one end of fourth runner is the fourth aperture, the other end of fourth runner is for leading to the fifth aperture of first face, still be provided with on the first face with the fourth and one or more reaction chamber that the fifth aperture corresponds, the fifth aperture set up in the reaction chamber, still be provided with the valve hole that is used for taking out the negative pressure on the first face, first face is equipped with and is used for laminating completely and covers its regional first apron, the second face is equipped with and is used for laminating completely and covers its regional second apron.
2. A blood sample testing chip device according to claim 1, wherein: the bottom of the sample hole is communicated with the main body through a first small hole.
3. A blood sample testing chip device according to claim 1, wherein: and a needle head is fixedly arranged at the bottom of the sample hole and communicated with the main body.
4. A blood sample testing chip device according to claim 1, wherein: the fifth small hole is arranged at the bottom side of the reaction cavity.
5. A blood sample testing chip device according to claim 1, wherein: the top side of the reaction cavity is also provided with a waste liquid hole, and the first surface is also provided with one or more waste liquid areas communicated with the waste liquid hole.
6. A blood sample testing chip device according to claim 1, wherein: and a freeze-drying reactant is arranged in the reaction cavity.
7. A blood sample testing chip device according to claim 1, wherein: the transfer pool is provided with four fourth small holes, correspondingly, the number of the fourth flow channels, the number of the fifth small holes and the number of the reaction cavities are four, and the reaction cavities are communicated with the transfer pool through the fourth flow channels respectively.
8. A blood sample testing chip device according to claim 1, wherein: the path lengths of the four fourth flow channels are identical.
9. A blood sample testing chip device according to claim 1, wherein: and a mixing ball is also arranged in the reaction cavity.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2018222322097 | 2018-12-28 | ||
| CN201822232209 | 2018-12-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN210775506U true CN210775506U (en) | 2020-06-16 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910577367.2A Pending CN110412256A (en) | 2018-12-28 | 2019-06-28 | A kind of blood sample test chip apparatus |
| CN201920997120.1U Active CN210775506U (en) | 2018-12-28 | 2019-06-28 | Blood sample test chip device |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201910577367.2A Pending CN110412256A (en) | 2018-12-28 | 2019-06-28 | A kind of blood sample test chip apparatus |
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| CN (2) | CN110412256A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110412256A (en) * | 2018-12-28 | 2019-11-05 | 苏州康容生物医疗科技有限公司 | A kind of blood sample test chip apparatus |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2016365824B2 (en) * | 2015-12-11 | 2022-07-21 | Opko Diagnostics, Llc | Fluidic systems involving incubation samples and/or reagents |
| CN205826513U (en) * | 2016-02-24 | 2016-12-21 | 庄泉洁 | A kind of blood sample provides device and platelet aggregation detector thereof |
| CN108686721B (en) * | 2017-04-06 | 2021-04-20 | 美康生物科技股份有限公司 | Micro-fluidic chip for separating and detecting whole blood sample and detection method thereof |
| CN207507497U (en) * | 2017-09-21 | 2018-06-19 | 深圳市海拓华擎生物科技有限公司 | A kind of micro-fluidic chip |
| CN109030812A (en) * | 2018-07-19 | 2018-12-18 | 东莞东阳光科研发有限公司 | A kind of micro-fluidic chip based on immune detection and biochemistry detection, detector and detection method |
| CN110412256A (en) * | 2018-12-28 | 2019-11-05 | 苏州康容生物医疗科技有限公司 | A kind of blood sample test chip apparatus |
-
2019
- 2019-06-28 CN CN201910577367.2A patent/CN110412256A/en active Pending
- 2019-06-28 CN CN201920997120.1U patent/CN210775506U/en active Active
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110412256A (en) * | 2018-12-28 | 2019-11-05 | 苏州康容生物医疗科技有限公司 | A kind of blood sample test chip apparatus |
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| CN110412256A (en) | 2019-11-05 |
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