CN110412256A - A kind of blood sample test chip apparatus - Google Patents
A kind of blood sample test chip apparatus Download PDFInfo
- Publication number
- CN110412256A CN110412256A CN201910577367.2A CN201910577367A CN110412256A CN 110412256 A CN110412256 A CN 110412256A CN 201910577367 A CN201910577367 A CN 201910577367A CN 110412256 A CN110412256 A CN 110412256A
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- face
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- blood sample
- runner
- main body
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- 239000008280 blood Substances 0.000 title claims abstract description 32
- 210000004369 blood Anatomy 0.000 title claims abstract description 32
- 238000012360 testing method Methods 0.000 title claims abstract description 30
- 238000012546 transfer Methods 0.000 claims abstract description 16
- 239000002699 waste material Substances 0.000 claims description 14
- 239000007788 liquid Substances 0.000 claims description 13
- 238000002156 mixing Methods 0.000 claims description 7
- 238000004108 freeze drying Methods 0.000 claims description 6
- 239000000376 reactant Substances 0.000 claims description 5
- 239000007787 solid Substances 0.000 claims 1
- 238000012545 processing Methods 0.000 abstract description 5
- 238000012856 packing Methods 0.000 abstract 1
- 238000002875 fluorescence polarization Methods 0.000 description 4
- 230000000694 effects Effects 0.000 description 3
- 239000002184 metal Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 238000002835 absorbance Methods 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 238000012408 PCR amplification Methods 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000010339 medical test Methods 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
Classifications
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Molecular Biology (AREA)
- Clinical Laboratory Science (AREA)
- Medicinal Chemistry (AREA)
- Cell Biology (AREA)
- Microbiology (AREA)
- Organic Chemistry (AREA)
- Dispersion Chemistry (AREA)
- Food Science & Technology (AREA)
- Biotechnology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
The invention discloses a kind of blood samples to test chip apparatus, including main body, sample well, the first cover board for covering the first face of main body, the second cover board for covering the second face of main body, it is provided on first face and incubates area, runner, transfer pond, reaction chamber, valve hole, the sample well is connected to by runner with area is incubated, and the reaction chamber is connected to by runner with the transfer pond.A variety of processing such as packing, example reaction are integrated in one by it, provide a kind of quickly easy-to-use Sample testing device, eliminate the various preceding processing operations carried out in liquor removing workstation.
Description
Technical field
The present invention relates to medical instruments fields, and in particular to a kind of blood sample test chip apparatus.
Background technique
Blood is to be most readily available in medical test and monitor one of maximally efficient sample and medicine to physical condition
The most common sample in inspection.The development of many modernization fully-automatic analyzers is also to be detected as base growth with blood sample to rise
Come, such as chemical illumination immunity analysis instrument, automatic clinical chemistry analyzer, the quality of machine pre-treatment is undoubtedly to knot on blood sample
The detection of fruit has vital effect.
In the prior art, it before testing blood sample, needs to carry out Sample pretreatment in liquor removing workstation, wraps
The sequence of operations such as mixing, extraction, PCR amplification, fluorescence reaction are included, process is complicated, and is easy to introduce other disturbing factors.
Summary of the invention
In order to solve the above-mentioned technical problems, the present invention provides a kind of blood samples to test chip apparatus, uses miniflow
Control technology to sampling sample and incubated samples dispensed, example reaction, by it is a variety of processing be integrated in one, be clinician and reality
The personnel of testing provide a kind of quickly easy-to-use device to test hospital, doctor's office, the liquid sample in laboratory environment, mention
For accurate test data.
It should be noted that test sample chip apparatus provided by the present invention is used not only for blood sample test,
It can be used for other any liquid samples.
The technical scheme adopted by the invention is as follows:
A kind of blood sample test chip apparatus, including main body, the side of the main body are provided with for receiving blood sample
This sample well, the sample well is connected to the main body, on the first face of the main body, is provided with one end and sample well connects
Logical first runner, the other end of the first runner be connected to incubate area, it is described incubate area bottom and second flow channel one
End connection, the other end of the second flow channel offer second orifice, and the second orifice is opened to the second face of the main body,
Third flow channel is provided on second face, one end of the third flow channel is second orifice, the other end of the third flow channel
The third aperture for leading to the first face is offered, the third aperture is located on the first face in a transfer pond, in the transfer pond
Also be additionally provided with it is one or more open to the 4th aperture in the second face, one or more the are provided on second face
Four runners, one end of the 4th runner are the 4th aperture, and the other end of the 4th runner is lead to the first face the 5th small
Hole, one or more reaction chambers corresponding with the 4th and the 5th aperture are additionally provided on first face, and the 5th aperture is set
It is placed in the reaction chamber, is additionally provided with the valve hole for taking out negative pressure on first face, first face is equipped with being used for
First cover board in its region is fitted over completely, and second face is equipped with the second lid for fitting over its region completely
Plate.
In a wherein technical solution, the sample well bottom is connected to by the way that the first aperture is arranged with the main body.
As improvement to above-mentioned technical proposal, the sample well bottom is fixedly installed a syringe needle, the syringe needle and institute
State main body connection.
In order to lenitively inject blood sample, the 5th aperture is set to the reaction chamber bottom side.
As improvement to above-mentioned technical proposal, in order to which waste liquid is discharged, the top side of the reaction chamber is additionally provided with useless
Fluid apertures is additionally provided with the one or more wastes being connected to the waste liquid hole on first face.
As improvement to above-mentioned technical proposal, freeze-drying reactant is provided in the reaction chamber.
Preferably, there are four the 4th aperture settings in the transfer pond, accordingly, the 4th runner, the described 5th
There are four aperture and the reaction chamber are respectively provided with, the reaction chamber passes through the 4th runner respectively and is connected with the transfer pond.
It is further preferred that the path length of four the 4th runners is identical.
In order to promote to react, mixing ball is additionally provided in the reaction chamber.
When testing blood sample, tester only need to be by the sample for the blood sample insertion apparatus being collected into
Hole reaches sample by runner and incubates area by valve hole to negative pressure is taken out in device, can use auxiliary tool incubating area
The early period for doing sample mixing formula incubates, and then again by valve hole, rotation runner continues to take out negative pressure, and sample enters reaction chamber by runner
It is interior, freeze-drying reaction is carried out by the way that reactant is lyophilized in reaction chamber, the effect of chrome-plated metal ball is to guarantee sufficiently reaction.
Using test chip apparatus of the invention, test method and light wave using unrestricted, wavelength, which can be used, is
The light wave of 100nm-650nm is suitable for absorbance (Abs), fluorescence intensity (FI), time-resolved fluorescence (TRF), fluorescence polarization
(FP) and the structure of chemiluminescence (Lum).
Beneficial effects of the present invention: blood sample test chip apparatus of the invention is using microflow control technique to sampling sample
And incubated samples are dispensed, example reaction, and a variety of processing are integrated in one, provide one kind for clinician and experimenter
Quick easy-to-use device tests hospital, doctor's office, the liquid sample in laboratory environment, provides accurately test number
According to, eliminate carried out in liquor removing workstation it is various before processing operation.
Detailed description of the invention
Fig. 1 show the view in the first face after removing the first cover board according to one embodiment of present invention；
Fig. 2 show the view in the second face after removing the second cover board according to one embodiment of present invention.
Specific embodiment
The present invention will be further explained below with reference to the attached drawings and specific examples, so that those skilled in the art can be with
It more fully understands the present invention and can be practiced, but illustrated embodiment is not as a limitation of the invention.
It referring to Figures 1 and 2, is a kind of one embodiment of blood sample test chip apparatus according to the present invention, packet
Main body 1 is included, the side of the main body 1 is provided with the sample well 2 for receiving blood sample, the sample well 2 and the main body 1
Connection, in a preferred embodiment, 2 bottom of sample well pass through the first aperture (not shown) of setting and the main body 1
Connection, in a further preferred embodiment, 2 bottom of sample well is fixedly installed a syringe needle 21, and the syringe needle 21 passes through
First aperture is connected to the main body 1.On the first face of the main body 1, as shown in Figure 1, being provided with one end and the company of sample well 2
Logical first runner 31, the other end of the first runner 31, which is connected to, incubates area 4, the bottom for incubating area 4 and second
The one end in road 32 is connected to, and the other end of the second flow channel 32 offers second orifice 52, and the second orifice 52 is opened to institute
The second face of main body to be stated, third flow channel 33 is provided on second face, one end of the third flow channel 33 is second orifice 52,
The other end of the third flow channel 33 offers the third aperture 53 for leading to the first face, the third aperture 53 position on the first face
In a transfer pond 6, one or more open to the 4th aperture 54, In in the second face is also additionally provided in the transfer pond 6
One or more 4th runners 34 are provided on second face, one end of the 4th runner 34 is the 4th aperture 54, described
The other end of 4th runner 34 is the 5th aperture 55 for leading to the first face, be additionally provided on first face with the 4th aperture 54 and
The corresponding one or more reaction chambers 7 of 5th aperture 55, the 5th aperture 55 are set in the reaction chamber 7, in order to
Blood sample is lenitively injected, the 5th aperture 55 is set to 7 bottom side of reaction chamber, is additionally provided with use on first face
In the valve hole 8 for taking out negative pressure, first face is equipped with the first cover board 91 for fitting over its region completely, and described second
Face is equipped with the second cover board 92 for fitting over its region completely.
In a preferred embodiment, in order to which waste reaction solution is discharged, the top side of the reaction chamber 7 is additionally provided with waste liquid hole
71, the one or more wastes 72 being connected to the waste liquid hole 71 are additionally provided on first face.
In a preferred embodiment, freeze-drying reactant is provided in the reaction chamber 7.
In preferred embodiment as illustrated in fig. 1 and 2, there are four the 4th aperture 54 settings in the transfer pond 6, right
Ying Di, there are four the 4th runner 34, the 5th aperture 55 and the reaction chamber 7 are respectively provided with, the reaction chamber 7 is distinguished
It is connected by the 4th runner 34 with the transfer pond 6.
In order to guarantee reaction chamber 7 while receive the blood sample of isodose, in a preferred embodiment, described four the 4th
The path length of runner 34 is identical with size.
In order to promote to react, it is additionally provided with mixing ball in the reaction chamber 7, in a preferred embodiment, the mixing ball
For chrome-plated metal ball.
When testing blood sample, tester only need to be by the sample well for the blood sample insertion apparatus being collected into
2, it, can be with incubating area 4 at this point, sample is reached by first runner 31 incubates area 4 by valve hole 8 to taking out negative pressure in device
It is incubated using the early period that auxiliary tool does sample mixing formula, then continues to take out negative pressure by valve hole 8 again, sample enters from area 4 is incubated
Second flow channel 32 enters the third flow channel 33 on the second face of device by second orifice 52, then by third flow channel 33
Third aperture 53 enters the transfer pond 6 on the first face of device, then enters the 4th runner by the 4th aperture 54 in transfer pond 6
34, finally by the 4th runner 34 the 5th aperture 55 enter reaction chamber 7 in, in reaction chamber 7 by freeze-drying reactant into
Row freeze-drying reaction, the effect of chrome-plated metal ball are to guarantee that sufficiently reaction, the waste liquid of reaction can pass through the waste liquid hole in reaction chamber 7
71 are discharged into waste liquid chamber 72, and the position setting of waste liquid chamber 72 can be arranged one or more according to the available space on device.
Using test chip apparatus of the invention, test method and light wave using unrestricted, wavelength, which can be used, is
The light wave of 100nm-650nm is suitable for absorbance (Abs), fluorescence intensity (FI), time-resolved fluorescence (TRF), fluorescence polarization
(FP) and the structure of chemiluminescence (Lum).
Embodiment described above is only to absolutely prove preferred embodiment that is of the invention and being lifted, protection model of the invention
It encloses without being limited thereto.Those skilled in the art's made equivalent substitute or transformation on the basis of the present invention, in the present invention
Protection scope within.Protection scope of the present invention is subject to claims.
Claims (9)
1. a kind of blood sample tests chip apparatus, including main body, it is characterised in that: the side of the main body is provided with for connecing
Receive blood sample sample well, the sample well is connected to the main body, on the first face of the main body, be provided with one end and
The first runner of sample well connection, the other end of the first runner, which is connected to, incubates area, the bottom and second for incubating area
One end of runner is connected to, and the other end of the second flow channel offers second orifice, and the second orifice is opened to the main body
The second face, third flow channel is provided on second face, one end of the third flow channel is second orifice, the third flow channel
The other end offer the third aperture for leading to the first face, the third aperture is located on the first face in a transfer pond, described
It is also additionally provided with one or more in transfer pond to open to the 4th aperture in the second face, is provided with one on second face
Or multiple 4th runners, one end of the 4th runner are the 4th aperture, the other end of the 4th runner is to lead to the first face
The 5th aperture, be additionally provided with one or more reaction chambers corresponding with the 4th and the 5th aperture on first face, described the
Five apertures are set in the reaction chamber, and the valve hole for taking out negative pressure is additionally provided on first face, and first face is matched
The first cover board for fitting over its region completely is had, second face equipped with for fitting over its region completely
Second cover board.
2. a kind of blood sample according to claim 1 tests chip apparatus, it is characterised in that: the sample well bottom is logical
The first aperture of setting is crossed to be connected to the main body.
3. a kind of blood sample according to claim 1 tests chip apparatus, it is characterised in that: the sample well bottom is solid
Surely it is provided with a syringe needle, the syringe needle is connected to the main body.
4. a kind of blood sample according to claim 1 tests chip apparatus, it is characterised in that: the 5th aperture setting
In the reaction chamber bottom side.
5. a kind of blood sample according to claim 1 tests chip apparatus, it is characterised in that: the top side of the reaction chamber
It is additionally provided with waste liquid hole, the one or more wastes being connected to the waste liquid hole are additionally provided on first face.
6. a kind of blood sample according to claim 1 tests chip apparatus, it is characterised in that: setting in the reaction chamber
There is freeze-drying reactant.
7. a kind of blood sample according to claim 1 tests chip apparatus, it is characterised in that: the in the transfer pond
There are four the settings of four apertures, accordingly, there are four the 4th runner, the 5th aperture and the reaction chamber are respectively provided with,
The reaction chamber passes through the 4th runner respectively and is connected with the transfer pond.
8. a kind of blood sample according to claim 1 tests chip apparatus, it is characterised in that: four the 4th runners
Path length it is identical.
9. a kind of blood sample according to claim 1 tests chip apparatus, it is characterised in that: also set in the reaction chamber
It is equipped with mixing ball.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201822232209 | 2018-12-28 | ||
| CN2018222322097 | 2018-12-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN110412256A true CN110412256A (en) | 2019-11-05 |
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Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201920997120.1U Active CN210775506U (en) | 2018-12-28 | 2019-06-28 | Blood sample test chip device |
| CN201910577367.2A Pending CN110412256A (en) | 2018-12-28 | 2019-06-28 | A kind of blood sample test chip apparatus |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201920997120.1U Active CN210775506U (en) | 2018-12-28 | 2019-06-28 | Blood sample test chip device |
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| CN (2) | CN210775506U (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN210775506U (en) * | 2018-12-28 | 2020-06-16 | 苏州康容生物医疗科技有限公司 | Blood sample test chip device |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN205826513U (en) * | 2016-02-24 | 2016-12-21 | 庄泉洁 | A kind of blood sample provides device and platelet aggregation detector thereof |
| US20170168077A1 (en) * | 2015-12-11 | 2017-06-15 | Opko Diagnostics, Llc | Fluidic systems involving incubation of samples and/or reagents |
| CN207507497U (en) * | 2017-09-21 | 2018-06-19 | 深圳市海拓华擎生物科技有限公司 | A kind of micro-fluidic chip |
| CN108686721A (en) * | 2017-04-06 | 2018-10-23 | 美康生物科技股份有限公司 | Micro-fluidic chip and its detection method for whole blood sample separation detection |
| CN109030812A (en) * | 2018-07-19 | 2018-12-18 | 东莞东阳光科研发有限公司 | A kind of micro-fluidic chip based on immune detection and biochemistry detection, detector and detection method |
| CN210775506U (en) * | 2018-12-28 | 2020-06-16 | 苏州康容生物医疗科技有限公司 | Blood sample test chip device |
-
2019
- 2019-06-28 CN CN201920997120.1U patent/CN210775506U/en active Active
- 2019-06-28 CN CN201910577367.2A patent/CN110412256A/en active Pending
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20170168077A1 (en) * | 2015-12-11 | 2017-06-15 | Opko Diagnostics, Llc | Fluidic systems involving incubation of samples and/or reagents |
| CN205826513U (en) * | 2016-02-24 | 2016-12-21 | 庄泉洁 | A kind of blood sample provides device and platelet aggregation detector thereof |
| CN108686721A (en) * | 2017-04-06 | 2018-10-23 | 美康生物科技股份有限公司 | Micro-fluidic chip and its detection method for whole blood sample separation detection |
| CN207507497U (en) * | 2017-09-21 | 2018-06-19 | 深圳市海拓华擎生物科技有限公司 | A kind of micro-fluidic chip |
| CN109030812A (en) * | 2018-07-19 | 2018-12-18 | 东莞东阳光科研发有限公司 | A kind of micro-fluidic chip based on immune detection and biochemistry detection, detector and detection method |
| CN210775506U (en) * | 2018-12-28 | 2020-06-16 | 苏州康容生物医疗科技有限公司 | Blood sample test chip device |
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| CN210775506U (en) | 2020-06-16 |
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