CN108434063A - It is a kind of have effects that releive repair skin care compositions and the preparation and application of sensitive skin - Google Patents
It is a kind of have effects that releive repair skin care compositions and the preparation and application of sensitive skin Download PDFInfo
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- CN108434063A CN108434063A CN201810574524.XA CN201810574524A CN108434063A CN 108434063 A CN108434063 A CN 108434063A CN 201810574524 A CN201810574524 A CN 201810574524A CN 108434063 A CN108434063 A CN 108434063A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/44—Aminocarboxylic acids or derivatives thereof, e.g. aminocarboxylic acids containing sulfur; Salts; Esters or N-acylated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/75—Anti-irritant
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Abstract
The invention belongs to cosmetic technical field, disclose it is a kind of have effects that releive repair skin care compositions and the preparation and application of sensitive skin.The composition is by plant extracts 10%~20%, glycine betaine 5%~10%, 1,3 propylene glycol 20%~30% and water composition；The plant extracts includes Flos Chrysanthemi Indici extract, dendrobium candidum extract, shrubby sophora extract and aloe extract.Deionized water is heated to 70~90 DEG C, it is uniform that glycine betaine, 1,3 propylene glycol stirring and dissolvings are added；45 DEG C are cooled to hereinafter, plant extracts is added, stirring and dissolving is uniform, obtain it is described have effects that releive repair the skin care compositions of sensitivity skin.The composition of the present invention selects raw material of naturally releiving to be made, and applied to that can reduce histamine release in skin care item, inhibits hyaluronidase activity, repairs skin barrier function, reduce the irritation of skin care item, has effects that mild, the sensitive skin of reparation of releiving.
Description
Technical field
The invention belongs to cosmetic technical fields, and in particular to it is a kind of have effects that releive repair the skin care group of sensitive skin
Close object and preparation and application.
Background technology
Sensitive skin is skin to the physiology overreaction state of environment or internal factor and non-disease, using there is stimulation
The skin care item of property, or because environmental factor and seasonal variations can all aggravate the malaise symptoms of skin, seriously affect daily life
Quality.
Sensibility skin is a kind of special skin type, and skin is very easy to stimulated, the facial tight feeling of generation, shouting pain
Sense, numb gargalesthesia, burning sensation, pain, the gargalesthesia of duration；Erythema and flush, edematous condition；Other uncomfortable skin symptoms
Deng.
It is exactly that skin barrier is impaired to cause the basic reason of sensibility skin.
Skin barrier function is impaired to be mainly manifested in following aspect：The imperfect and skin of skin epidermis cuticula structure
The imbalance of intercellular lipid content causes the content of ceramide to reduce；Skin transepidermal water loss rate increases, and cuticula is aqueous
Amount reduces；Skin surface temperature is too low or excessively high.
For reduce skin by the cosmetics stimulation of adverse reaction cause skin occur it is red and swollen, itch and allergic dermatitis
Etc. abnormal phenomenon, for sensibility skin crowd, occur in the market it is a have effects that releive repair the skin care of sensitive skin
Product.
This kind of product follows the originals such as " potential sensibiligen minimum ", " reducing the stimulation to skin " " rebuilding skin barrier "
Then, preferential to select the natural plants such as raw material, such as centella, chamomile, honeysuckle of naturally releiving, with anti-inflammatory, it is anti-oxidant,
Improve angiorrhoxis phenomenon and improve skin to the susceptibility and other effects of caloric stimulation, safety is relatively high.
But currently, have effects that releive repair sensitive skin skin-protection product type it is still less, the selection space of consumer
It is very limited.
Invention content
For the above prior art, the primary purpose of the present invention is that providing one kind having effects that the sensitive skin of reparation of releiving
Skin care compositions.The composition has reduction sensibiligen, inhibits inflammatory factor release, repairs the function of damaged skin barrier.
Another object of the present invention is to provide the systems of the above-mentioned skin care compositions for having effects that releive and repairing sensitive skin
Preparation Method.
It is still another object of the present invention to provide it is above-mentioned have effects that releive repair the skin care compositions conduct of sensitive skin
The application of skin-care product additive.
The object of the invention is achieved through the following technical solutions：
It is a kind of have effects that releive repair the skin care compositions of sensitive skin, be grouped as by the group of following weight percentage：
Plant extracts 10%~20%, glycine betaine 5%~10%, 1,3-PD 20%~30%, surplus are water；The plant
Extract includes Flos Chrysanthemi Indici extract, dendrobium candidum extract, shrubby sophora extract and aloe extract.
Further, the plant extracts further includes edenweiss flower extract, jasmine flower extract, purslane extraction
At least one of object, Radix et Caulis Opuntiae Dillenii extract, Radix Gentianae extract.
The preparation method of the above-mentioned skin care compositions for repairing sensitive skin that has effects that releive, including following preparation process：
(1) deionized water is heated to 70~90 DEG C, it is uniform that glycine betaine, 1,3-PD stirring and dissolving is added；
(2) mixed system of step (1) is cooled to 45 DEG C hereinafter, plant extracts is added, stirring and dissolving is uniform, obtains
It is described have effects that releive repair the skin care compositions of sensitive skin.
Further, the plant extracts is prepared via a method which：
(1) each Chinese medicine material is weighed by following parts by weight：10-15 parts of wild chrysanthemum, 10-15 parts of dendrobium candidum, kuh-seng 8-15
Part；5-10 parts of aloe；
(2) alkaline aqueous solution preliminary purification is first used, clear liquid, dialysis removal heteroion and foreign protein, activated carbon decolorizing are taken；
(3) and then using volume fraction the ethanol water for being 30%~65% is 60~90 DEG C in temperature as extractant,
Pressure is extracted under conditions of being 10.5~16.5MPa, and after gained extracting solution filtering with microporous membrane, recycling ethyl alcohol is concentrated under reduced pressure,
It is freeze-dried again to obtain plant extracts.
Further, Chinese medicine material described in step (1) further includes 2-3 parts of edelweiss.
Further, Chinese medicine material described in step (1) further includes 2-3 parts of Jasmine.
Further, Chinese medicine material described in step (1) further includes 2-5 parts of purslane.
Further, Chinese medicine material described in step (1) further includes 1-2 parts of cactus.
Further, Chinese medicine material described in step (1) further includes 1-2 parts of felwort.
Further, alkaline aqueous solution described in step (2) refers to the NaOH aqueous solutions that mass concentration is 0.5%.
It is above-mentioned to have effects that application of the skin care compositions for repairing sensitive skin as skin-care product additive of releiving.
The present invention preparation method and obtained product has the following advantages that and advantageous effect：
(1) composition of the invention selects raw material of naturally releiving to be made, and is applied to sensitive skin repair series skin product
In can reduce histamine release, inhibit hyaluronidase activity, repair skin barrier function, reduce the irritation of skin care item, have
Mildly, the effect of reparation of releiving sensitive skin.
(2) dendrobium candidum extract derives from green natural Chinese medicine class plant in composition of the invention, belongs to very warm
The bioactive substance of sum, active component content is high, is added not only nonirritant in cosmetics but also has moisture retention.
(3) preparation method of the plant extracts active constituent in the present composition is compared with common extracting method,
It is less with consumption of organic solvent, it is safer, environmentally friendly；Extraction efficiency is high, and selectivity is good；Property easy to use, safe is preferably excellent
Point.
(4) present invention is using eye irritation test-chick chorioallantoic membrane experiment and human efficiency's evaluation test-sensitivity flesh
Skin efficacy assessments test method is to the basic security for being applied to repair the composition of sensitive skin and both effectiveness has carried out point
Analysis is repaired sensitive skin series of products to exploitation and is had a very important significance.
Description of the drawings
Fig. 1 is that embodiment resulting composition carries out the front and back result figure of chicken embryo chorioallantois film test sample-adding.
Fig. 2 is to be tested respectively at the 0th day, the 7th day and the 14th day after composition of the embodiment of the present invention is smeared by face
Result figure of taking pictures.
Specific implementation mode
With reference to embodiment, the present invention is described in further detail, and embodiments of the present invention are not limited thereto.
Embodiment 1
The present embodiment it is a kind of have effects that releive repair the skin care compositions of sensitive skin, per 100g by following component systems
At：Plant extracts 20g, glycine betaine 10g, 1,3-PD 25g, surplus are water.
It is prepared via a method which to obtain：
(1) prepared plant extracts
(1) wild chrysanthemum 15g, dendrobium candidum 10g, kuh-seng 15g, aloe 5g, edelweiss 3g, Jasmine 2g, purslane are weighed
3g, cactus 1g, felwort 2g.
(2) the NaOH aqueous solution preliminary purifications for first using 0.5wt.% take clear liquid, dialysis removal heteroion and foreign protein, living
Property carbon decoloring 1h.
(3) using the ethanol water of 30vt.% as extractant, temperature setting is under 65 DEG C, pressure 13.5MPa, extraction
Number 3 times, extraction time 10min.After membrane filtration by gained extracting solution with aperture 0.45um, recycling ethyl alcohol is concentrated under reduced pressure extremely
Without alcohol taste, then freeze-dried obtain plant extracts.
(2) deionized water 50g is weighed, is heated to 70~90 DEG C, glycine betaine 5g, 1,3-PD 30g stirring and dissolvings is added
Completely；
(3) mixed system of step (2) is cooled to 45 DEG C, plant extracts 20g prepared by step (1) is added, stirs
It mixes dissolving and repairs the skin care compositions of sensitive skin completely to get having effects that releive.
Embodiment 2
The present embodiment it is a kind of have effects that releive repair the skin care compositions of sensitive skin, per 100g by following component systems
At：Plant extracts 15g, glycine betaine 10g, 1,3-PD 20g, surplus are water.
It is prepared via a method which to obtain：
(1) prepared plant extracts
(1) wild chrysanthemum 10g, dendrobium candidum 15g, kuh-seng 10g, aloe 10g, edelweiss 2g, Jasmine 3g, purslane are weighed
3g, cactus 2g, felwort 1g.
(2) the NaOH aqueous solution preliminary purifications for first using 0.5wt.% take clear liquid, dialysis removal heteroion and foreign protein, living
Property carbon decoloring 1h.
(3) using the ethanol water of 40vt.% as extractant, temperature setting is under 70 DEG C, pressure 13.5MPa, extraction
Number 3 times, extraction time 10min.After membrane filtration by gained extracting solution with aperture 0.45um, recycling ethyl alcohol is concentrated under reduced pressure extremely
Without alcohol taste, then freeze-dried obtain plant extracts.
(2) deionized water 60g is weighed, is heated to 70~90 DEG C, glycine betaine 5g, 1,3-PD 25g stirring and dissolvings is added
Completely；
(3) mixed system of step (2) is cooled to 45 DEG C, plant extracts 10g prepared by step (1) is added, stirs
It mixes dissolving and repairs the skin care compositions of sensitive skin completely to get having effects that releive.
Embodiment 3
The present embodiment it is a kind of have effects that releive repair the skin care compositions of sensitive skin, per 100g by following component systems
At：Plant extracts 10g, glycine betaine 5g, 1,3-PD 25g, surplus are water.
It is prepared via a method which to obtain：
(1) prepared plant extracts
(1) wild chrysanthemum 12g, dendrobium candidum 10g, kuh-seng 10g, aloe 10g, edelweiss 3g, Jasmine 3g, purslane are weighed
5g, cactus 1g, felwort 1g.
(2) the NaOH aqueous solution preliminary purifications for first using 0.5wt.% take clear liquid, dialysis removal heteroion and foreign protein, living
Property carbon decoloring 1h.
(3) using the ethanol water of 60vt.% as extractant, temperature setting is under 80 DEG C, pressure 14MPa, extraction time
Number 2 times, extraction time 12min.After membrane filtration by gained extracting solution with aperture 0.45um, recycling ethyl alcohol is concentrated under reduced pressure to nothing
Alcohol taste, then freeze-dried obtain plant extracts.
(2) deionized water 60g is weighed, is heated to 70~90 DEG C, glycine betaine 5g, 1,3-PD 25g stirring and dissolvings is added
Completely；
(3) mixed system of step (2) is cooled to 45 DEG C, plant extracts 10g prepared by step (1) is added, stirs
It mixes dissolving and repairs the skin care compositions of sensitive skin completely to get having effects that releive.
Embodiment 4
The present embodiment it is a kind of have effects that releive repair the skin care compositions of sensitive skin, per 100g by following component systems
At：Plant extracts 12g, glycine betaine 8g, 1,3-PD 22g, surplus are water.
It is prepared via a method which to obtain：
(1) prepared plant extracts
(1) wild chrysanthemum 10g, dendrobium candidum 10g, kuh-seng 8g, aloe 12g, edelweiss 3g, Jasmine 3g, purslane are weighed
4g, cactus 2g, felwort 1g.
(2) the NaOH aqueous solution preliminary purifications for first using 0.5wt.% take clear liquid, dialysis removal heteroion and foreign protein, living
Property carbon decoloring 1h.
(3) using the ethanol water of 50vt.% as extractant, temperature setting is under 80 DEG C, pressure 14MPa, extraction time
Number 2 times, extraction time 12min.After membrane filtration by gained extracting solution with aperture 0.45um, recycling ethyl alcohol is concentrated under reduced pressure to nothing
Alcohol taste, then freeze-dried obtain plant extracts.
(2) deionized water 58g is weighed, is heated to 70~90 DEG C, glycine betaine 8g, 1,3-PD 22g stirring and dissolvings is added
Completely；
(3) mixed system of step (2) is cooled to 45 DEG C, plant extracts 12g prepared by step (1) is added, stirs
It mixes dissolving and repairs the skin care compositions of sensitive skin completely to get having effects that releive.
Application effect is tested：
When specifically used, composition prepared by the embodiment of the present invention 1~4 is added in skin care item, accounting for of additive amount
The 1%~10% of cosmetic quality.Can according to prepare releive repair class cosmetics common process and auxiliary material, be prepared into Essence,
The skin protection cosmetics such as lotion, cream.
Further, in order to better illustrate advantages of the present invention, for sensitive skin serial cosmetics, use is distinctive
Safety and both effectiveness carry out test analysis of the cosmetic industry evaluation method to resulting composition of the present invention, testing result is such as
Under：
1, chicken embryo chorioallantois film test (HET-CAM experiments)
Experimental method：It is 0.9% sodium chloride solution that negative control sample, which selects mass concentration, after tested material effect
Flushing and negative control, positive control sample 1%SDS.Chicken embryo is taken out from incubator, is placed in homemade egg rack, gas chamber
End upward, after opening gas chamber, adds a small amount of sodium chloride solution in making its wetting in egg shell membrane, sucks sodium chloride solution, careful with curved tweezer
Inner membrance is removed, ensures that tunica vasculose is not damaged.The structure of vascular system should be observed again at this time, and to its integrality and whether suitable
It is judged for testing.A certain amount of 1%~10% formulated embodiment resulting composition solution is taken to be added dropwise to CAM films
On, it the phenomenon that observing the inner membrance blood vessel of its 1~5min, records, while being taken pictures with high definition camera and food preservation test picture, knot
Fruit is as shown in Figure 1.
Test result：1%~10% composition solution of the embodiment of the present invention is added dropwise in chicken embryo inner membrance clearly branch's blood
At pipe, the blood vessel after 5min occurs without phenomena such as bleeding, haemolysis and blood coagulation.Illustrate that the composition of the present invention is basic to human skin
It is nonirritant, more mildly.
2, human efficiency's evaluation-sensitivity skin efficacy assessments experiment
Experimental method：It is sensitive skin or the crowd for being in allergy (rubescent, itch) to filter out at least 10 faces
As sensitive skin volunteer, pass through blank control, after composition of the embodiment of the present invention is smeared by face, difference within (18~45 years old)
It was tested at the 0th day, the 7th day and the 14th day, surveys its skin moisture content, skin water loss amount, skin color, skin blood
It red pigment value and takes pictures (such as Fig. 2), these indexs are the reparation energy of skin for evaluating skin barrier function and using after product
Power.
Volunteer 20 is recruited in the experiment altogether, and effective volunteer is 20 and data are effective.Test has carried out 2 weeks altogether,
Using skin moisture content, skin water loss amount, skin ferroheme value is detected before and after sample, compares its difference, as a result divide
Not as shown in table 1~3.
1 skin moisture content of table
As a result：Compared with control sides, after sample 2 weeks, the skin moisture content of sample side has apparent increase.
2 skin water loss of table
As a result：Compared with compareing and surveying, after sample 2 weeks, the skin water loss of sample side is decreased obviously.
3 skin ferroheme value of table
As a result：After sticking, the skin ferroheme value of sample area and check plot dramatically increases, and the incrementss of sample area
Substantially less than check plot.I.e. sample has the symptom for mitigating skin injury to a certain extent.
By the above results as can be seen that the cosmetics prepared using the present composition, can obviously repair skin after 2 weeks
Skin barrier releives and repairs skin at sensitivity, mitigates skin injury to a certain extent, improves skin sensitivity and pruritis.
The above embodiment is a preferred embodiment of the present invention, but embodiments of the present invention are not by above-described embodiment
Limitation, it is other it is any without departing from the spirit and principles of the present invention made by changes, modifications, substitutions, combinations, simplifications,
Equivalent substitute mode is should be, is included within the scope of the present invention.
Claims (10)
1. it is a kind of have effects that releive repair the skin care compositions of sensitive skin, it is characterised in that by the group of following weight percentage
It is grouped as：Plant extracts 10%~20%, glycine betaine 5%~10%, 1,3-PD 20%~30%, surplus are water；Institute
The plant extracts stated includes Flos Chrysanthemi Indici extract, dendrobium candidum extract, shrubby sophora extract and aloe extract.
2. it is according to claim 1 it is a kind of have effects that releive repair the skin care compositions of sensitive skin, it is characterised in that：
The plant extracts further includes edenweiss flower extract, jasmine flower extract, purslane extract, Radix et Caulis Opuntiae Dillenii extract, dragon
At least one of courage grass extract.
3. a kind of preparation method of skin care compositions for repairing sensitive skin that has effects that releive as claimed in claim 1 or 2,
It is characterized in that including following preparation process：
(1) deionized water is heated to 70~90 DEG C, it is uniform that glycine betaine, 1,3-PD stirring and dissolving is added；
(2) mixed system of step (1) is cooled to 45 DEG C hereinafter, plant extracts is added, stirring and dissolving is uniform, obtains described
Have effects that releive and repairs the skin care compositions of sensitive skin.
4. a kind of preparation method of skin care compositions for repairing sensitive skin that has effects that releive according to claim 3,
It is characterized in that the plant extracts is prepared via a method which：
(1) each Chinese medicine material is weighed by following parts by weight：10-15 parts of wild chrysanthemum, 10-15 parts of dendrobium candidum, 8-15 parts of kuh-seng；Reed
5-10 parts of luxuriant growth；
(2) alkaline aqueous solution preliminary purification is first used, clear liquid, dialysis removal heteroion and foreign protein, activated carbon decolorizing are taken；
(3) and then using volume fraction the ethanol water for being 30%~65% is 60~90 DEG C in temperature as extractant, pressure
To be extracted under conditions of 10.5~16.5MPa, after gained extracting solution filtering with microporous membrane, recycling ethyl alcohol is concentrated under reduced pressure, then pass through
Freeze-drying obtains plant extracts.
5. a kind of preparation method of skin care compositions for repairing sensitive skin that has effects that releive according to claim 4,
It is characterized in that：Chinese medicine material described in step (1) further includes 2-3 parts of edelweiss.
6. a kind of preparation method of skin care compositions for repairing sensitive skin that has effects that releive according to claim 4,
It is characterized in that：Chinese medicine material described in step (1) further includes 2-3 parts of Jasmine.
7. a kind of preparation method of skin care compositions for repairing sensitive skin that has effects that releive according to claim 4,
It is characterized in that：Chinese medicine material described in step (1) further includes 2-5 parts of purslane.
8. a kind of preparation method of skin care compositions for repairing sensitive skin that has effects that releive according to claim 4,
It is characterized in that：Chinese medicine material described in step (1) further includes 1-2 parts of cactus.
9. a kind of preparation method of skin care compositions for repairing sensitive skin that has effects that releive according to claim 4,
It is characterized in that：Chinese medicine material described in step (1) further includes 1-2 parts of felwort.
10. it is as claimed in claim 1 or 2 it is a kind of have effects that releive repair the skin care compositions of sensitive skin and add as skin care item
Add the application of agent.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111671701A (en) * | 2020-06-09 | 2020-09-18 | 广州友品位生物科技有限公司 | Sensitive muscle repairing composition and preparation method thereof |
| CN115137675A (en) * | 2022-08-03 | 2022-10-04 | 珠海远大美业生物科技有限公司 | Compound plant extract with moisturizing effect and application thereof |
| CN115737491A (en) * | 2022-03-23 | 2023-03-07 | 北京东方淼森生物科技有限公司 | Plant composition and preparation method and application thereof |
| CN115944576A (en) * | 2022-11-21 | 2023-04-11 | 烟台新时代健康产业日化有限公司 | Composition for repairing sensitive skin, mask liquid and mask |
| EP4173676A1 (en) * | 2021-10-27 | 2023-05-03 | Weleda AG | Cosmetic composition comprising an extract of gentiana and leontopodium and / or centella |
| CN116672296A (en) * | 2023-08-01 | 2023-09-01 | 珠海远大美业生物科技有限公司 | Compound plant extract with soothing and repairing effects, and preparation method and application thereof |
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