CN108403758A - Removing beriberi cream and preparation method thereof - Google Patents
Removing beriberi cream and preparation method thereof Download PDFInfo
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Abstract
The present invention relates to the field of Chinese medicines, and more particularly to a kind of removing beriberi cream and preparation method thereof.The removing beriberi cream is made of plurality of raw materials, in parts by weight, above-mentioned plurality of raw materials includes 5 15 parts of litharges, 5 15 parts of sulphur, 0.5 2.5 parts of borneols, 12 27 parts of boraxs, 38 parts of salicylic acids, 38 parts of camphors, 15 parts of menthols, 150 250 parts of vaseline and 10 20 parts of paraffin.Its energy Quick itch stopping, kills germ, can rapid healing tinea pedis.
Description
Technical field
The present invention relates to the field of Chinese medicines, and more particularly to a kind of removing beriberi cream and preparation method thereof.
Background technology
Tinea pedis (popular name " athlete's foot ", tinea pedis), is that fungal infection causes, and skin lesion is often first unilateral (i.e. single foot)
Occur, just offside is arrived in infection after several weeks or several months.Blister mainly appears on toe abdomen and toe side, is most commonly between three or four toes, vola
Also it may occur in which, be deep-seated phlysis, can gradually be fused into bleb.The skin lesion of tinea pedis has a feature, i.e. clear border, can
Gradually extend to the outside.Because of progression of the disease or scratching, rotten to the corn, sepage may occur in which, even, there is warts etc. in bacterium infection.Tinea pedis is
A kind of chronic infection, growth and breeding in fungi autoeciousness cuticula, needs long-term administration that could thoroughly remove.Therefore, the symptom of tinea pedis
After alleviation, still need to adhere to medication, the metabolism period of skin is 28 days or so, and administration time has to adhere to surrounding or more.It is best
Fungus examination and culture are carried out, continuous three week is all that negative just calculate is cured.The time for the treatment of tinea pedis is long in the prior art, and rises
Effect is slow, it is often necessary to several days time somewhat effect.
Invention content
The purpose of the present invention is to provide a kind of removing beriberi cream, energy Quick itch stopping kills germ, can rapid healing foot
Tinea.
Another object of the present invention is to provide a kind of preparation method of removing beriberi cream, this method is easy to operate, operates item
Part is mildly easily achieved, being capable of effectively save resource.
The present invention solves its technical problem using following technical scheme to realize：
The present invention proposes that a kind of removing beriberi cream, the removing beriberi cream are made of plurality of raw materials.In parts by weight, above-mentioned a variety of originals
Material includes 5-15 parts of litharges, 5-15 parts of sulphur, 0.5-2.5 parts of borneols, 12-27 parts of boraxs, 3-8 parts of salicylic acids, 3-8 portions of camphor trees
Brain, 1-5 part menthol, 150-250 parts of vaseline and 10-20 parts of paraffin.
The present invention proposes a kind of preparation method of removing beriberi cream, includes the following steps：
In parts by weight, by 5-15 parts of litharges, 5-15 parts of sulphur, 0.5-2.5 parts of borneols, 12-27 parts of boraxs, 3-8 parts
It is mixed to get again with 150-250 parts of vaseline and 10-20 parts of paraffin after salicylic acid, 3-8 part camphor and 1-5 parts of menthol mixing
The first mixture mixed.
The advantageous effect of removing beriberi cream of the present invention is：The removing beriberi cream of the present invention utilizes 5-15 parts of litharges, 5-15 parts of sulphur
Sulphur, 0.5-2.5 part borneol, 12-27 parts of boraxs, 3-8 parts of salicylic acids, 3-8 parts of camphors, 1-5 parts of menthols, 150-250 parts of all scholars
Woods and 10-20 parts of paraffin inhibit bacterial growth, promote running sore healing, promote antipruritic removing beriberi cream, sterilization, promote Wound healing
Effect, ensure the therapeutic effect of removing beriberi cream, promote absorption of the skin to removing beriberi cream, while being formed and being protected to skin, prevent
The only diffusion of inflammation, the effects that further to borax, sulphur, borneol, the effect of improving removing beriberi cream so that removing beriberi cream energy
It is enough quickly to inhibit bacterial growth, it is antipruritic, relieve the pain, it prevents lesion from spreading, can quickly treat tinea pedis.
Specific implementation mode
It in order to make the object, technical scheme and advantages of the embodiment of the invention clearer, below will be in the embodiment of the present invention
Technical solution be clearly and completely described.The person that is not specified actual conditions in embodiment, builds according to normal condition or manufacturer
The condition of view carries out.Reagents or instruments used without specified manufacturer is the conventional production that can be obtained by commercially available purchase
Product.
In the description of the present invention, it should be noted that term " first ", " second " etc. are only used for distinguishing description, without
It can be interpreted as indicating or implying relative importance.
Removing beriberi cream of the embodiment of the present invention and preparation method thereof is specifically described below.
A kind of removing beriberi cream provided in an embodiment of the present invention, the removing beriberi cream are made of plurality of raw materials.In parts by weight, on
State raw material include 5-15 parts of litharges, 5-15 parts of sulphur, 0.5-2.5 parts of borneols, 12-27 parts of boraxs, 3-8 parts of salicylic acids, 3-8 parts
Camphor, 1-5 part menthol, 150-250 parts of vaseline and 10-20 parts of paraffin.Preferably, plurality of raw materials includes 8-13 parts of close tops
Monk, 8-13 parts of sulphur, 0.5-1 parts of borneols, 15-20 parts of boraxs, 3-5 parts of salicylic acids, 5-8 parts of camphors, 1-3 parts of menthols, 150-
200 parts of vaseline and 10-15 parts of paraffin.It is further preferred that plurality of raw materials includes 10-12 parts of litharges, 10-12 parts of sulphur
Sulphur, 1.5-2 part borneol, 20-25 parts of boraxs, 3-5 parts of salicylic acids, 3-5 parts of camphors, 1-3 parts of menthols, 210-240 parts of vaseline
And 16-18 parts of paraffin.
When each raw material in removing beriberi cream uses aforementioned proportion, the synergistic effect between each component can reach best
Effect, and the ratio recorded above or below the embodiment of the present invention, the effect or function of each component will decrease, simultaneously
Synergistic effect between component, which will also decrease, even to disappear.Borax is that monarch drug in a prescription main function is the life that can restrain, inhibit germ
It is long, and litharge and sulphur are then ministerial drug, can enhance the effect of borax so that removing beriberi cream has preferably sterilization, convergence
The effect of, while making removing beriberi cream that there is antipruritic effect.And borneol, menthol etc. can further strengthen removing beriberi cream and stop
The effect of itching, sterilizing, meanwhile, borneol, menthol, camphor etc. can reduce the toxicity of the drugs such as borax, sulphur in removing beriberi cream.
And salicylic acid can promote absorption of the skin to each drug, enhance the drug effect of removing beriberi cream.And vaseline, paraffin then can be right
Skin carries out moisturizing, isolation air, is further ensured that absorption and utilization of the human body to each drug, while can prevent bacterium
Diffusion.The raw materials interaction such as borax, litharge, sulphur, borneol, menthol, camphor and salicylic acid, vaseline and paraffin, is protected
Card drug can quickly be absorbed by the body and then play drug effect, can Quick itch stopping, anti-inflammatory, sterilize, prevent lesion from spreading, ensure
The therapeutic effect of removing beriberi cream.
Litharge is called sweet top monk, does not have more monks, litharge to have the effect of detumescence desinsection, convergence anti-corrosion, promoting expectoration to arrest convulsion, close top
Monk plays the role for the treatment of hemorrhoid, pyogenic infections, body odour, wound, protracted dysentery, ulcer, eczema, frightened epilepsy, and taste is salty pungent, mild-natured toxic.At this
Its main function is can to restrain in inventive embodiments so that the malignant sore convergence festered, and bacterium can be killed.
Sulphur, alias sulphur, colloid sulphur, Sulfur block.Appearance is the crystallization of faint yellow brittleness or powder, there is off-odor.Its work(
Effect is that external application energy desinsection is antipruritic.It can be used for mange, eczema, pruitus.Existing science and technology thinks that sulphur has the function of that sterilization is
Sulphur and generation hydrogen sulfide and pentathionic acid after skin contact, can kill sarcoptic mite, killing fungus, moreover it is possible to lose hair or feathers.In the embodiment of the present invention
In, the effect of sulphur is itch-stopping bactericidal.
Borax is borate family borax race mineral borax, has the effect of heat-clearing and phlegm-dissolving, detoxifying and anticorrosive.It is for oral administration, control phlegm heat
Cough and dysphagic accumulation, all bone sticking larynxs；Abscess of throat, aphthae, the cataract triangular mass of mucous membrane growing from the inner corner of the eye, pudendal ulcer are controlled in external application.Its taste
It is sweet, salty, it is cool in nature.In embodiments of the present invention, main function is can to restrain and have antibacterial effect.
Borneol also known as piece brain, orange slices, L-Borneol, kapur, MEIHUA BINGPIAN etc. are by composite family Blumea balsamifera cauline leaf or Lauraceae
Plant borneol camphor tree branches and leaves are through steam distillation and recrystallize and obtain.Its gas faint scent, it is acrid flavour, cool, there is an inducing resuscitation of having one's ideas straightened out, heat-clearing dissipates poison,
The effect of removing nebula, cures mainly aphtha tooth swells, sore carbuncle infantile malnutrition due to digestive disturbances or intestinalparasites hemorrhoid.In embodiments of the present invention, the major function of borneol is can to disappear
It is swollen, inflammation caused by tinea pedis is eliminated, while having effects that myogenic, the healing of foot's rotten position can be promoted.
Salicylic acid is a kind of fat-soluble organic acid, has superior fat-soluble, low to skin irritation, can go deep into pore
It is interior, while salicylic acid can dissolve the framework formative substance between cutin so that cuticula falls off, and can remove and gather blocked up angle
Matter layer promotes the metabolism of skin.Therefore, salicylic effect can soften or remove and tells somebody what one's real intentions are in embodiments of the present invention
Blocked up cutin promotes absorption of the skin to each drug, meanwhile, promote the healing of foot's skin.
Camphor is the branch, dry, leaf and root of canella camphor tree, through crystalline particulate made from refinement.Camphor has clearance
Key, qi stagnation removing ward off the effect of foul, desinsection is antipruritic, swelling and pain relieving, cure mainly the symptoms such as mange itch, injuries from falls as well, toothache.
It is that can ease pain, is antipruritic the effect of camphor in the embodiment of the present invention, fungi of curing the disease can also be inhibited.
Menthol is to be extracted in leaf and stem by peppermint, white crystal, molecular formula C10H20O is used as thorn in medicine
Swash medicine, acts on skin or mucous membrane, there is refrigerant itching-relieving action.Be the effect of menthol in embodiments of the present invention can anti-inflammatory,
Antipruritic and analgesic.
Vaseline is the mixture of a kind of methane series hydrocarbon or saturated hydrocarbons semi liquid state, is also vaseline, by being made after petroleum fractionating.
Its state is at room temperature between solid and liquid, Hydrolyzed Protein, maintenance skin, the effect of alleviating dry skin.It is inventing
It is that can be formed on its surface a tunic on the skin the effect of vaseline in embodiment, so that moisture is not easy to evaporate lost, Ke Yibao
It is moisture state to hold skin, stops that the bacterium and skin contact in air avoid simultaneously to reduce the possibility of infection
The diffusion of infection.Further, it is preferable to ground, vaseline selects albolene.
Paraffin is also known as crystalline wax, the hydrocarbon mixture that carbon atom number is about 18~30, and key component is that linear paraffin (is about
80%~95%), the monocyclic naphthenes of the alkane and belt length side chain also on a small quantity with individual branches.Paraffin has moisture-proof, waterproof
The effect of, in embodiments of the present invention the effect of paraffin be can waterproof, completely cut off air, reduce infected wound inflammation diffusion can
It can property.
Further, plurality of raw materials further includes 1-5 portions of Asian puccoons.Asian puccoon (Classification system：RADIX ARNEBIAE/RADIX
LITHOSPERMI), alias：Gromwell root, radix macrotomiae.Asian puccoon nature and flavor are sweet, salty, tremble with fear.Converge to heart and liver channels.There is cool blood, invigorate blood circulation, removing toxic substances is saturating
The function of rash.The healing of its foot's running sore that can detoxify, promote in embodiments of the present invention.
The present invention also provides a kind of methods preparing removing beriberi cream：
S1, the second mixture is prepared；
In parts by weight, by 5-15 parts of litharges, 5-15 parts of sulphur, 0.5-2.5 parts of borneols, 12-27 parts of boraxs, 3-8 parts
Salicylic acid, 3-8 part camphor and 1-5 parts of menthols carry out being mixed to get the second mixture.First, above-mentioned substance is subjected to powder respectively
It is broken, then the substance after crushing is sieved by 14-20 mesh so that the grain size of the drug after crushing is close, is then acted on human body
When, human body is close to the degree of absorption of each drug, then ensures the synergistic effect between drug.
Further, the camphor after crushing, menthol, salicylic acid, borneol and ethyl alcohol mixing, since above-mentioned substance is dissolved in
Ethyl alcohol, said medicine ensure that the active ingredient contained in each drug is dissolved in ethyl alcohol after being dissolved in ethyl alcohol so that it is each effectively at
Divide and exist as a solution, improves the absorption and utilization of each drug.Above-mentioned each drug is mixed with ethyl alcohol, can be above-mentioned
Each drug mixes after being mixed respectively with ethyl alcohol by the ethyl alcohol for being dissolved with corresponding drug, can also be above-mentioned each drug
It is mixed jointly with ethyl alcohol again after first mixing.The ingredient for the mixed liquor being prepared using above two mode, content all same, are controlled
Therapeutic effect also substantially close to.
Further, it is concentrated after camphor, menthol, salicylic acid, borneol and ethyl alcohol mixing, the multiple of concentration is camphor tree
The 1/2-2/3 for the mixed liquor that brain, menthol, salicylic acid, borneol and ethyl alcohol are mixed to get.Since the drug of preparation is paste, if
Obtained removing beriberi cream is excessively diluted containing quantity of solvent is excessively high, and the adhesion force difference with foot is easy to fall off, thereby reduces
The therapeutic effect of beriberi paste.Meanwhile solvent content is excessively high so that the content of the active ingredient of removing beriberi cream reduces, and then causes
The therapeutic effect of removing beriberi cream reduces.Therefore, ensure the content of active ingredient in removing beriberi cream using concentration.
Further, since camphor, menthol, borneol etc. contain volatile substance, in order to ensure each drug
Active ingredient do not reduce or disappear with the evaporation of ethyl alcohol in concentration process, condensing mode of the invention using
Traditional vacuum concentration systems, traditional vacuum concentration systems are that comprehensive comprehensive utilization centrifugal force, heating and external vacuum pump provide
Vacuum action carries out evaporation of the solvent, can quickly remove alcohol solvent, without by the volatile substance band such as camphor
Go out, then ensures that the type of each active ingredient and content do not change in removing beriberi cream, then ensure controlling for removing beriberi cream
Therapeutic effect.
After the completion of concentration, concentrate is mixed with litharge, sulphur and the borax after crushing, and above-mentioned three kinds of substances are hardly
It is dissolved in ethyl alcohol, is present in the form of full medicine in removing beriberi cream substantially so that the active ingredient in three kinds of substances can be by people
Body is absorbed and is utilized.
S2, the first mixture is prepared；
In parts by weight, the first mixture 150-250 parts of vaseline and 10-20 parts of paraffin being mixed to get.Specifically
Ground, the first mixture are the melts that heating melting obtains after mixing vaseline and paraffin.Can also be vaseline and paraffin point
The melt remixed after Jia Re not melting.Since paraffin is solid, and its effect is isolation moisture and oxygen, therefore is
Enable paraffin to play its effect, need to be heated melting, and vaseline be then between liquid and solid, in order to
Ensure that it can form skin to protect, it is also desirable to which it is in solution status and then is uniformly mixed with other each drugs, ensures
Each drug can play its effect.The temperature of heating melting is 70-80 DEG C, in the temperature range, paraffin and the equal energy of vaseline
It is melted by heating.
S3, removing beriberi cream is prepared；
First mixture is mixed with the second mixture, specifically the first mixture is added to the second mixing
In object.The viscosity of first mixture is larger, is not easy to stir evenly, and the second mixture is solidliquid mixture, when the first mixing
When object is added slowly in the second mixture, the first mixture can be rapidly uniformly mixed with the second mixture, be reduced
It is uniformly mixed required time and cost, ensures the drug effect of removing beriberi cream.
Further, it when the first mixture and the second mixture are mixed, needs to carry out at heat preservation the first mixture
Reason prevents the first mixture from solidifying, and ensures that the first mixture and the second mixture are uniformly mixed.The temperature of heat preservation is to heat to melt
Melt the temperature of paraffin and vaseline.
Further, when the first mixture and the second mixture after mixing, in order to ensure removing beriberi cream treatment effect
Fruit and extend its service life, the substance being mixed to get to the first mixture and the second mixture sterilizes.Due to removing foot
Gas cream itself has certain fungistatic effect, and therefore, sterilizing only needs to remove the bacterium that may be introduced in preparation process, carries out
Primary sterilization, i.e. sterilizing are to use ultraviolet radiation sterilization, and irradiation time is 3-5 minutes.
The removing beriberi cream of the present invention inhibits bacterial growth using borax, promotes running sore healing, at the same borax and litharge and
Sulphur interaction promotes antipruritic removing beriberi cream, sterilization, the effect for promoting Wound healing, ensures the therapeutic effect of removing beriberi cream.
Meanwhile the toxicity of borax, sulphur is offset in borax, litharge, sulphur and borneol, menthol and camphor interaction, meanwhile, it is capable to
Antipruritic, sterilization, further promotes the drug effect of removing beriberi cream, and salicylic acid, vaseline and paraffin can promote skin to removing beriberi
The absorption of cream, while skin is formed and is protected, the diffusion of inflammation is prevented, it is complete the effects that further to borax, sulphur, borneol
The effect of kind removing beriberi cream so that removing beriberi cream can quickly inhibit bacterial growth, antipruritic, relieve the pain, and prevent lesion from spreading, can
Quickly treatment tinea pedis.
The feature and performance of the present invention are described in further detail with reference to embodiments.
Embodiment 1
Removing beriberi cream provided in this embodiment is made of plurality of raw materials.Plurality of raw materials include 15g litharge, 5g sulphur,
0.5g borneols, 27g boraxs, 3g salicylic acids, 8g camphors, 5g menthols, 250g vaseline and 10g paraffin.
The preparation method of removing beriberi cream provided in this embodiment：
S1, the second mixture is prepared；
15g litharge, 5g sulphur, 0.5g borneols, 27g boraxs, 3g salicylic acids, 8g camphors and 5g menthols are carried out respectively
It crushes, and is sieved respectively by 15 mesh.Solution ethanol after then mixing camphor, menthol, salicylic acid and borneol then utilizes true
Empty centrifugal concentrating system is concentrated, and the multiple of concentration is the 1/2 of camphor, menthol, salicylic acid, borneol and alcohol mixeding liquid.
After the completion of concentration, concentrate is uniformly mixed with litharge, sulphur and the borax after crushing.
S2, the first mixture is prepared；
Heating, which melts, under the conditions of 70 DEG C, after 250g vaseline and 10g paraffin are mixed obtains the mixing of melt i.e. first
Object.
S3, removing beriberi cream is prepared；
Under the conditions of 70 DEG C, the first mixture is added in the second mixture and is uniformly mixed, then ultraviolet light irradiation is gone out
Bacterium, irradiation time are 5 minutes.
Embodiment 2
Removing beriberi cream provided in this embodiment is made of plurality of raw materials.Plurality of raw materials include 5g litharge, 10g sulphur,
2.5g borneols, 20g boraxs, 8g salicylic acids, 5g camphors, 1g menthols, 150g vaseline and 20g paraffin.
The preparation method of removing beriberi cream provided in this embodiment：
S1, the second mixture is prepared；
5g litharge, 10g sulphur, 2.5g borneols, 20g boraxs, 8g salicylic acids, 5g camphors and 1g menthols are carried out respectively
It crushes, and is sieved respectively by 14 mesh.Solution ethanol after then mixing camphor, menthol, salicylic acid and borneol then utilizes true
Empty centrifugal concentrating system is concentrated, and the multiple of concentration is the 2/3 of camphor, menthol, salicylic acid, borneol and alcohol mixeding liquid.
After the completion of concentration, concentrate is uniformly mixed with litharge, sulphur and the borax after crushing.
S2, the first mixture is prepared；
Under the conditions of 75 DEG C, 150g vaseline and 20g paraffin are heated respectively to be uniformly mixed after melting obtains melt i.e.
First mixture.
S3, removing beriberi cream is prepared；
Under the conditions of 75 DEG C, the first mixture is added in the second mixture and is uniformly mixed, then ultraviolet light irradiation is gone out
Bacterium, irradiation time are 4 minutes.
Embodiment 3
Removing beriberi cream provided in this embodiment is made of plurality of raw materials.Plurality of raw materials include 10g litharge, 12g sulphur,
1.5g borneols, 25g boraxs, 5g salicylic acids, 3g camphors, 3g menthols, 240g vaseline and 16g paraffin.
The preparation method of removing beriberi cream provided in this embodiment：
S1, the second mixture is prepared；
Respectively by 10g litharge, 12g sulphur, 1.5g borneols, 25g boraxs, 5g salicylic acids, 3g camphors and 3g menthols into
Row crushes, and is sieved respectively by 20 mesh.Solution ethanol after then mixing camphor, menthol, salicylic acid and borneol, then utilizes
Traditional vacuum concentration systems are concentrated, and the multiple of concentration is the 7/ of camphor, menthol, salicylic acid, borneol and alcohol mixeding liquid
12.After the completion of concentration, concentrate is uniformly mixed with litharge, sulphur and the borax after crushing.
S2, the first mixture is prepared；
Under the conditions of 80 DEG C, 240g vaseline and 16g paraffin are heated respectively to be uniformly mixed after melting obtains melt i.e.
First mixture.
S3, removing beriberi cream is prepared；
Under the conditions of 80 DEG C, the first mixture is added in the second mixture and is uniformly mixed, then ultraviolet light irradiation is gone out
Bacterium, irradiation time are 3 minutes.
Embodiment 4
Removing beriberi cream provided in this embodiment is made of plurality of raw materials.Plurality of raw materials includes 13g litharge, 8g sulphur, 1g
Borneol, 20g boraxs, 3g salicylic acids, 5g camphors, 2g menthols, 200g vaseline and 15g paraffin.
The preparation method of removing beriberi cream provided in this embodiment：
S1, the second mixture is prepared；
13g litharge, 8g sulphur, 1g borneols, 20g boraxs, 3g salicylic acids, 5g camphors and 2g menthols are subjected to powder respectively
It is broken, and sieved respectively by 16 mesh.Solution ethanol after then mixing camphor, menthol, salicylic acid and borneol then utilizes vacuum
Centrifugal concentrating system is concentrated, and the multiple of concentration is the 1/2 of camphor, menthol, salicylic acid, borneol and alcohol mixeding liquid.It is dense
After the completion of contracting, concentrate is uniformly mixed with litharge, sulphur and the borax after crushing.
S2, the first mixture is prepared；
Under the conditions of 72 DEG C, 200g vaseline and 15g paraffin are heated respectively to be uniformly mixed after melting obtains melt i.e.
First mixture.
S3, removing beriberi cream is prepared；
Under the conditions of 72 DEG C, the first mixture is added in the second mixture and is uniformly mixed, then ultraviolet light irradiation is gone out
Bacterium, irradiation time are 3 minutes.
Embodiment 5
Removing beriberi cream provided in this embodiment is made of plurality of raw materials.Plurality of raw materials include 8g litharge, 13g sulphur,
0.7g borneols, 15g boraxs, 4g salicylic acids, 8g camphors, 1g menthols, 170g vaseline, 12g paraffin and 5g Asian puccoons.
The preparation method of removing beriberi cream provided in this embodiment：
S1, the second mixture is prepared；
It is respectively that 8g litharge, 13g sulphur, 0.7g borneols, 15g boraxs, 4g salicylic acids, 8g camphors, 5g Asian puccoons and 1g is thin
Lotus brain crushes, and is sieved respectively by 18 mesh.Solution ethanol after then mixing camphor, menthol, salicylic acid and borneol, and
It is concentrated afterwards using traditional vacuum concentration systems, the multiple of concentration is camphor, menthol, salicylic acid, borneol and ethyl alcohol mixing
The 2/3 of liquid.After the completion of concentration, concentrate is uniformly mixed with litharge, sulphur, Asian puccoon and the borax after crushing.
S2, the first mixture is prepared；
Under the conditions of 77 DEG C, 170g vaseline and 12g paraffin are heated respectively to be uniformly mixed after melting obtains melt i.e.
First mixture.
S3, removing beriberi cream is prepared；
Under the conditions of 77 DEG C, the first mixture is added in the second mixture and is uniformly mixed, then ultraviolet light irradiation is gone out
Bacterium, irradiation time are 4 minutes.
Embodiment 6
Removing beriberi cream provided in this embodiment is made of plurality of raw materials.Plurality of raw materials includes 12g litharge, 11g sulphur, 2g
Borneol, 22g boraxs, 5g salicylic acids, 4g camphors, 3g menthols, 210g vaseline, 18g paraffin and 3g Asian puccoons.
The preparation method of removing beriberi cream provided in this embodiment：
S1, the second mixture is prepared；
It is respectively that 2g litharge, 11g sulphur, 2g borneols, 22g boraxs, 5g salicylic acids, 4g camphors, 3g menthols and 3g is purple
Grass crushes, and is sieved respectively by 14 mesh.Solution ethanol after then mixing camphor, menthol, salicylic acid and borneol, then
It is concentrated using traditional vacuum concentration systems, the multiple of concentration is camphor, menthol, salicylic acid, borneol and alcohol mixeding liquid
2/3.After the completion of concentration, concentrate is uniformly mixed with litharge, sulphur, Asian puccoon and the borax after crushing.
S2, the first mixture is prepared；
Under the conditions of 75 DEG C, 210g vaseline and 18g paraffin are heated respectively to be uniformly mixed after melting obtains melt i.e.
First mixture.
S3, removing beriberi cream is prepared；
Under the conditions of 75 DEG C, the first mixture is added in the second mixture and is uniformly mixed, then ultraviolet light irradiation is gone out
Bacterium, irradiation time are 3 minutes.
Embodiment 7
Removing beriberi cream provided in this embodiment is made of plurality of raw materials.Plurality of raw materials include 14g litharge, 15g sulphur,
2.2g borneols, 12g boraxs, 6g salicylic acids, 7g camphors, 4g menthols, 190g vaseline, 13g paraffin and 1g Asian puccoons.
The preparation method of removing beriberi cream provided in this embodiment：
S1, the second mixture is prepared；
Respectively by 14g litharge, 15g sulphur, 2.2g borneols, 12g boraxs, 6g salicylic acids, 7g camphors, 4g menthols and 1g
Asian puccoon crushes, and is sieved respectively by 20 mesh.Solution ethanol after then mixing camphor, menthol, salicylic acid and borneol, and
It is concentrated afterwards using traditional vacuum concentration systems, the multiple of concentration is camphor, menthol, salicylic acid, borneol and ethyl alcohol mixing
The 2/3 of liquid.After the completion of concentration, concentrate is uniformly mixed with litharge, sulphur, Asian puccoon and the borax after crushing.
S2, the first mixture is prepared；
Under the conditions of 80 DEG C, 190g vaseline and 13g paraffin are heated into melting after mixing and obtain melt i.e. first
Mixture.
S3, removing beriberi cream is prepared；
Under the conditions of 80 DEG C, the first mixture is added in the second mixture and is uniformly mixed, then ultraviolet light irradiation is gone out
Bacterium, irradiation time are 3 minutes.
Embodiment 8
Removing beriberi cream provided in this embodiment is made of plurality of raw materials.Plurality of raw materials include 11g litharge, 10g sulphur,
1.7g borneols, 20g boraxs, 3g salicylic acids, 5g camphors, 1g menthols, 230g vaseline, 17g paraffin and 2g Asian puccoons.
The preparation method of removing beriberi cream provided in this embodiment：
S1, the second mixture is prepared；
Respectively by 11g litharge, 10g sulphur, 1.7g borneols, 20g boraxs, 3g salicylic acids, 5g camphors, 1g menthols and 2g
Asian puccoon crushes, and is sieved respectively by 16 mesh.Solution ethanol after then mixing camphor, menthol, salicylic acid and borneol, and
It is concentrated afterwards using traditional vacuum concentration systems, the multiple of concentration is camphor, menthol, salicylic acid, borneol and ethyl alcohol mixing
The 1/2 of liquid.After the completion of concentration, concentrate is uniformly mixed with litharge, sulphur, Asian puccoon and the borax after crushing.
S2, the first mixture is prepared；
Under the conditions of 70 DEG C, 230g vaseline and 17g paraffin are heated into melting after mixing and obtain melt i.e. first
Mixture.
S3, removing beriberi cream is prepared；
Under the conditions of 70 DEG C, the first mixture is added in the second mixture and is uniformly mixed, then ultraviolet light irradiation is gone out
Bacterium, irradiation time are 4 minutes.
Embodiment 9
Removing beriberi cream provided in this embodiment is made of plurality of raw materials.Plurality of raw materials includes 9g litharge, 9g sulphur, 0.5g
Borneol, 17g boraxs, 5g salicylic acids, 6g camphors, 1g menthols, 150g vaseline, 10g paraffin and 4g Asian puccoons.
The preparation method of removing beriberi cream provided in this embodiment：
S1, the second mixture is prepared；
It is respectively that 9g litharge, 9g sulphur, 0.5g borneols, 17g boraxs, 5g salicylic acids, 6g camphors, 1g menthols and 4g is purple
Grass crushes, and is sieved respectively by 18 mesh.Solution ethanol after then mixing camphor, menthol, salicylic acid and borneol, then
It is concentrated using traditional vacuum concentration systems, the multiple of concentration is camphor, menthol, salicylic acid, borneol and alcohol mixeding liquid
1/2.After the completion of concentration, concentrate is uniformly mixed with litharge, sulphur, Asian puccoon and the borax after crushing.
S2, the first mixture is prepared；
Under the conditions of 76 DEG C, 150g vaseline and 10g paraffin are heated into melting after mixing and obtain melt i.e. first
Mixture.
S3, removing beriberi cream is prepared；
Under the conditions of 76 DEG C, the first mixture is added in the second mixture and is uniformly mixed, then ultraviolet light irradiation is gone out
Bacterium, irradiation time are 5 minutes.
Experimental example
Comparative example 1：The plurality of raw materials for preparing removing beriberi cream includes 4g litharge, 2g sulphur, 0.1g borneols, 10g boraxs, 2g
Salicylic acid, 2g camphors, 0.5g menthols, 100g vaseline and 8g paraffin, the preparation method of remaining preparation method and embodiment 1
The removing beriberi cream being unanimously prepared.
Comparative example 2：Prepare removing beriberi cream plurality of raw materials include 20g litharge, 18g sulphur, 3g borneols, 30g boraxs,
10g salicylic acids, 12g camphors, 8g menthols, 300g vaseline and 30g paraffin, the preparation of remaining preparation method and embodiment 1
The removing beriberi cream that method is consistent and is prepared.
Experimental example 1
The bacteriostatic experiment detection of candida albicans is carried out to the removing beriberi cream that embodiment 1-9 and comparative example 1-2 are prepared, specifically
Detection method《Pharmacopoeia of People's Republic of China》Middle inhibitory effect inspection technique is detected.Specific testing result is referring to table 1.
1 bacteriostatic experiment result of table
By table 1, wherein the lg values of reduction indicate：The bacterium number lg values that each interval time measures are with 1ml (g) for examination
The phase difference for the bacterium number lg values being inoculated in product.NI is indicated：Do not increase, refers to previous minute, the increased number of test organisms
Amount is no more than 0.5lg.The removing beriberi cream that embodiment 1-9 is prepared has good inhibition, embodiment 2- for candida albicans
Embodiment 7 and embodiment 9 are after using removing beriberi cream 6 hours, and the lg values of reduction have reached 1, and not so good effect is gone in use
After beriberi paste 24 hours, the lg values of reduction have reached 1, but have had the effect of fabulous, medicine for other opposite removing beriberi cream
The standard of skin drug-delivery preparation is the requirement that can be only achieved reduced lg values after 14 days in medication and have reached 1 in allusion quotation standard.This hair
Requirement of the bright action time well below pharmacopeia.Meanwhile the time of the NI of standards of pharmacopoeia record is 28 days, and longest of the present invention
To be 5 days or even embodiment 2- embodiments 7 and embodiment 9 do not increased using removing beriberi cream after 2 days, illustrate going for the present invention
Beriberi paste has good fungistatic effect.
Comparison 1 comparative example 2 of comparative example and the testing result of experimental example 1 using comparative example 1 and comparative example 2 it is found that go
The lg values of beriberi paste reduction after 30 days just reach 1, and fungistatic effect illustrates note of the present invention far below the fungistatic effect of the present invention
The ratio of a bulk pharmaceutical chemicals carried is particularly important.
Experimental example 2
Select 40-50 Sui, 550 tinea pedis patients are divided into 11 groups of patients, every group smeared in same time it is same amount of
Removing beriberi cream；Daily 9 points of smearings at night are primary.Wherein, tinea pedis patient all has scratchiness, cracking, redness, pain, erosion
And the symptoms such as blister.It was paid a return visit respectively into row information with 24 hours and 3 days.
Wherein, the symptoms such as scratchiness, cracking, redness, pain, erosion and blister are eased and are determined as effectively, it will
The one symptom disappearance of the symptoms such as scratchiness, cracking, redness, pain, erosion and blister be determined as it is effective, by scratchiness, cracking,
The disappearance of the symptoms such as redness, pain, erosion and blister is judged to fully recovering.Concrete outcome is shown in Table 2.
2 tinea pedis patient of table improves situation
By table 2 it is found that the removing beriberi cream that 1- of embodiment of the present invention embodiments 9 provide has fabulous treatment to imitate tinea pedis
Fruit, the patient for having 88% at 24 hours after the removing beriberi cream using the present invention at least show as effectively.Using fully recovering after 3 days
Rate is up to 50% or more, with traditional 7 days even more than fully recover compared with, be greatly shortened tinea pedis recovery from illness time.To comparing
The result of ratio 1, comparative example 2 and embodiment 1 is it is found that the ratio of change raw material of the present invention will cause it for the treatment of tinea pedis
Effect drastically reduces, invalid after 3 days to be still up to 86% using the patient of comparative example 1 and 2.
Experimental example 3
To showing as after 3 days arbitrarily choosing in effective and recovery from illness patient using the removing beriberi cream of embodiment 1-9 in experimental example 2
It selects 10 patients to carry out fungal culture detection, detects whether the presence of also fungi.Concrete outcome is referring to table 3.
3 fungal culture of table detects
By table 3 it is found that at least 60% patient is showed since fungi is killed completely in effective patient
To be effective, at least 70% patient is to show as fully recovering since fungi is killed completely in the patient of recovery from illness, and surface is real
It is fabulous to apply the removing beriberi cream bactericidal effect that a 1-9 is prepared.
In conclusion 1-9 removing beriberi cream of the embodiment of the present invention inhibits bacterial growth using borax, promote running sore healing, together
When borax and litharge and sulphur interaction promote antipruritic removing beriberi cream, sterilization, the effect for promoting Wound healing, foot is removed in guarantee
The therapeutic effect of gas cream.Meanwhile borax, sulphur are offset in borax, litharge, sulphur and borneol, menthol and camphor interaction
Toxicity, meanwhile, it is capable to which antipruritic, sterilization, further promotes the drug effect of removing beriberi cream, and salicylic acid, vaseline and paraffin can
Promote absorption of the skin to removing beriberi cream, while skin is formed and is protected, the diffusion of inflammation is prevented, further to borax, sulphur
The effects that sulphur, borneol, the effect of improving removing beriberi cream so that removing beriberi cream can quickly inhibit bacterial growth, antipruritic, relieve the pain,
It prevents lesion from spreading, can quickly treat tinea pedis.
Embodiments described above is a part of the embodiment of the present invention, instead of all the embodiments.The reality of the present invention
The detailed description for applying example is not intended to limit the range of claimed invention, but is merely representative of the selected implementation of the present invention
Example.Based on the embodiments of the present invention, those of ordinary skill in the art are obtained without creative efforts
Every other embodiment, shall fall within the protection scope of the present invention.
Claims (10)
1. a kind of removing beriberi cream, which is characterized in that the removing beriberi cream is made of plurality of raw materials, in parts by weight, described a variety of
Raw material includes 5-15 parts of litharges, 5-15 parts of sulphur, 0.5-2.5 parts of borneols, 12-27 parts of boraxs, 3-8 parts of salicylic acids, 3-8 portions of camphor trees
Brain, 1-5 part menthol, 150-250 parts of vaseline and 10-20 parts of paraffin.
2. removing beriberi cream according to claim 1, which is characterized in that the plurality of raw materials includes the 8-13 parts of close tops
Monk, the 8-13 parts of sulphur, the 0.5-1 parts of borneols, the 15-20 parts of boraxs, the 3-5 parts of salicylic acids, the 5-8 parts of camphor trees
Brain, the 1-3 parts of menthols, the 150-200 parts of vaseline and the 10-15 parts of paraffin.
3. removing beriberi cream according to claim 1, which is characterized in that the plurality of raw materials includes the 10-12 parts of close tops
Monk, the 10-12 parts of sulphur, the 1.5-2 parts of borneols, the 20-25 parts of boraxs, the 3-5 parts of salicylic acids, described in 3-5 parts
Camphor, the 1-3 parts of menthols, the 210-240 parts of vaseline and the 16-18 parts of paraffin.
4. removing beriberi cream according to claim 1, which is characterized in that the plurality of raw materials further includes 1-5 portions of Asian puccoons.
5. a kind of method preparing removing beriberi cream, which is characterized in that include the following steps：In parts by weight, by 5-15 parts of close tops
Monk, 5-15 parts of sulphur, 0.5-2.5 parts of borneols, 12-27 parts of boraxs, 3-8 parts of salicylic acids, 3-8 parts of camphors and 1-5 parts of menthols are mixed
The first mixture being mixed to get again with 150-250 parts of vaseline and 10-20 parts of paraffin after conjunction is mixed.
6. the method according to claim 5 for preparing removing beriberi cream, which is characterized in that first mixture is will be described
Vaseline and the paraffin are mixed and heated the melt obtained after melting.
7. the method according to claim 5 for preparing removing beriberi cream, which is characterized in that the litharge, the sulphur, institute
It is by described the to state borneol, the borax, the salicylic acid, the camphor, the menthol and first mixture mixing
One mixture is added to the litharge, sulphur, the borneol, the borax, the salicylic acid, the camphor, described
In the second mixture that menthol is mixed to get.
8. the method according to claim 5 for preparing removing beriberi cream, which is characterized in that the litharge, the sulphur, institute
It is by the camphor, the menthol, institute to state borneol, the borax, the salicylic acid, the camphor and menthol mixing
It is mixed with the litharge, the sulphur and the borax after stating salicylic acid, the borneol and ethyl alcohol mixing.
9. the method according to claim 8 for preparing removing beriberi cream, which is characterized in that the camphor, the menthol, institute
Concentrated after stating salicylic acid, the borneol and ethyl alcohol mixing, the multiple of concentration is the camphor, the menthol, institute
State the 1/2-2/3 for the mixed liquor that salicylic acid, the borneol and the ethyl alcohol are mixed to get.
10. it is according to claim 5 prepare removing beriberi cream method, which is characterized in that the litharge, the sulphur,
It goes out after the borneol, the borax, the salicylic acid, the camphor, the menthol and first mixture mixing
Bacterium.
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| CN101204399A (en) * | 2007-12-19 | 2008-06-25 | 干慕美 | External medicine for tinea pedis |
| CN107050059A (en) * | 2017-03-13 | 2017-08-18 | 南通蛇类治疗研究所 | Jiaoqiling for beriberi nanometer emulsifiable paste |
| CN107320519A (en) * | 2017-08-29 | 2017-11-07 | 王红芝 | One kind treats dermopathic ointment |
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Application publication date: 20180817 |