CN108366975A - 使用脱氧胆酸和其盐对堆积的脂肪的治疗 - Google Patents

使用脱氧胆酸和其盐对堆积的脂肪的治疗 Download PDF

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Publication number
CN108366975A
CN108366975A CN201680073076.4A CN201680073076A CN108366975A CN 108366975 A CN108366975 A CN 108366975A CN 201680073076 A CN201680073076 A CN 201680073076A CN 108366975 A CN108366975 A CN 108366975A
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CN
China
Prior art keywords
fat
dca
composition
pharmaceutically acceptable
armpit
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201680073076.4A
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English (en)
Chinese (zh)
Inventor
F·贝丁菲尔德
E·桑多瓦尔
N·约尔格森
S·利希特斯坦纳
P·利祖尔
T·格罗斯
C·索莫吉
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aierjian Sales Co ltd
Original Assignee
Kythera Biopharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kythera Biopharmaceuticals LLC filed Critical Kythera Biopharmaceuticals LLC
Publication of CN108366975A publication Critical patent/CN108366975A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • A61K31/035—Halogenated hydrocarbons having aliphatic unsaturation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Inorganic Chemistry (AREA)
  • Dermatology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
CN201680073076.4A 2015-11-04 2016-11-04 使用脱氧胆酸和其盐对堆积的脂肪的治疗 Pending CN108366975A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562251014P 2015-11-04 2015-11-04
US62/251,014 2015-11-04
PCT/US2016/060731 WO2017079700A1 (en) 2015-11-04 2016-11-04 Treatments of accumulated fat with deoxycholic acid and salts thereof

Publications (1)

Publication Number Publication Date
CN108366975A true CN108366975A (zh) 2018-08-03

Family

ID=57389528

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201680073076.4A Pending CN108366975A (zh) 2015-11-04 2016-11-04 使用脱氧胆酸和其盐对堆积的脂肪的治疗

Country Status (9)

Country Link
US (2) US20170119794A1 (enExample)
EP (1) EP3370710A1 (enExample)
JP (1) JP2018532806A (enExample)
KR (1) KR20180100309A (enExample)
CN (1) CN108366975A (enExample)
AU (1) AU2016349516A1 (enExample)
CA (1) CA3003746A1 (enExample)
MX (1) MX2018005628A (enExample)
WO (1) WO2017079700A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115867321A (zh) * 2020-06-12 2023-03-28 凯尔格恩有限公司 具有抗肥胖活性的脱氧胆酸-肽缀合物及其用途
CN116617160A (zh) * 2023-07-25 2023-08-22 山东则正医药技术有限公司 水性混悬液及制备方法、冻干粉及应用、脂肪消减注射剂

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8101593B2 (en) 2009-03-03 2012-01-24 Kythera Biopharmaceuticals, Inc. Formulations of deoxycholic acid and salts thereof
MX363465B (es) 2011-02-18 2019-03-25 Kythera Biopharmaceuticals Inc Tratamiento de la grasa submental.
WO2019203511A1 (ko) * 2018-04-16 2019-10-24 주식회사 펜믹스 데옥시콜릭산을 포함하는 약학 조성물
KR102064864B1 (ko) * 2019-02-08 2020-01-10 (주)제테마 국소 주사용 조성물
DE102020006049A1 (de) 2020-10-02 2022-04-07 Radim Vlcek Desoxycholsäure sowie deren Verbindungen zur Verwendung bei der Behandlung von Erkrankungen

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060127468A1 (en) * 2004-05-19 2006-06-15 Kolodney Michael S Methods and related compositions for reduction of fat and skin tightening
EP2561876A1 (en) * 2011-08-23 2013-02-27 Kythera Biopharmaceuticals, Inc. Formulations of Deoxycholic Acid and Salts Thereof

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US2661530A (en) * 1951-06-05 1953-12-08 John F Cavanagh Magazine safety razor
FR2754709B1 (fr) 1996-10-23 1999-03-05 Sanofi Sa Composition cosmetique contenant un antagoniste des recepteurs du neuropeptide gamma et alpha 2 antagonistes susceptibles d'etre incorpores dans une telle composition
US7097501B2 (en) * 2003-11-25 2006-08-29 Schlumberger Technology Corporation Micro coated electrical feedthru
EP3424508B1 (en) * 2004-05-19 2021-05-05 Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center Use of sodium deoxycholate for the removal of localized fat accumulation
US7754230B2 (en) * 2004-05-19 2010-07-13 The Regents Of The University Of California Methods and related compositions for reduction of fat
US8436190B2 (en) * 2005-01-14 2013-05-07 Cephalon, Inc. Bendamustine pharmaceutical compositions
EP1888101B1 (en) 2005-06-06 2012-03-21 Georgetown University Compositions and methods for lipo modeling
KR101598402B1 (ko) * 2007-06-19 2016-03-03 키쎄라 바이오파마슈티컬즈 인코포레이티드 합성 담즙산 조성물, 방법 및 제조물
JOP20180077A1 (ar) * 2007-06-19 2019-01-30 Kythera Biopharmaceuticals Inc تركيبات وطرق لحمض صفراوي تخليقي
US8242294B2 (en) * 2007-06-19 2012-08-14 Kythera Biopharmaceuticals, Inc. Synthetic bile acid compositions and methods
US7943187B2 (en) * 2008-05-23 2011-05-17 Bakr Rabie Paeoniflorin preparations and uses thereof for fat reduction
US8101593B2 (en) * 2009-03-03 2012-01-24 Kythera Biopharmaceuticals, Inc. Formulations of deoxycholic acid and salts thereof
DK3158991T3 (da) * 2010-01-28 2021-06-14 Eagle Pharmaceuticals Inc Formuleringer af bendamustin
MX363465B (es) * 2011-02-18 2019-03-25 Kythera Biopharmaceuticals Inc Tratamiento de la grasa submental.
US8653058B2 (en) * 2011-04-05 2014-02-18 Kythera Biopharmaceuticals, Inc. Compositions comprising deoxycholic acid and salts thereof suitable for use in treating fat deposits
EA029305B1 (ru) * 2011-08-23 2018-03-30 Китера Биофармасьютикалз, Инк. Составы дезоксихолевой кислоты и ее солей
US8426471B1 (en) * 2011-12-19 2013-04-23 Topokine Therapeutics, Inc. Methods and compositions for reducing body fat and adipocytes
US20150166958A1 (en) * 2012-07-12 2015-06-18 Kyoto Prefectural Public University Corporation Brown fat cells and method for preparing same

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060127468A1 (en) * 2004-05-19 2006-06-15 Kolodney Michael S Methods and related compositions for reduction of fat and skin tightening
EP2561876A1 (en) * 2011-08-23 2013-02-27 Kythera Biopharmaceuticals, Inc. Formulations of Deoxycholic Acid and Salts Thereof

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115867321A (zh) * 2020-06-12 2023-03-28 凯尔格恩有限公司 具有抗肥胖活性的脱氧胆酸-肽缀合物及其用途
CN115867321B (zh) * 2020-06-12 2025-05-20 凯尔格恩有限公司 具有抗肥胖活性的脱氧胆酸-肽缀合物及其用途
CN116617160A (zh) * 2023-07-25 2023-08-22 山东则正医药技术有限公司 水性混悬液及制备方法、冻干粉及应用、脂肪消减注射剂

Also Published As

Publication number Publication date
JP2018532806A (ja) 2018-11-08
AU2016349516A1 (en) 2018-05-31
US20170119794A1 (en) 2017-05-04
WO2017079700A1 (en) 2017-05-11
MX2018005628A (es) 2018-08-01
US20220072011A1 (en) 2022-03-10
CA3003746A1 (en) 2017-05-11
EP3370710A1 (en) 2018-09-12
KR20180100309A (ko) 2018-09-10

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PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
CB02 Change of applicant information

Address after: California, USA

Applicant after: Kesera biopharmaceutical Co.,Ltd.

Address before: New jersey, USA

Applicant before: Kythera Biopharmaceuticals, Inc.

CB02 Change of applicant information
TA01 Transfer of patent application right

Effective date of registration: 20201104

Address after: California, USA

Applicant after: Aierjian Sales Co.,Ltd.

Address before: California, USA

Applicant before: Kesera biopharmaceutical Co.,Ltd.

TA01 Transfer of patent application right
RJ01 Rejection of invention patent application after publication

Application publication date: 20180803

RJ01 Rejection of invention patent application after publication