CN108354991A - One Plant Extracts mouth sprays and its manufacturing method - Google Patents

One Plant Extracts mouth sprays and its manufacturing method Download PDF

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CN108354991A
CN108354991A CN201810362998.8A CN201810362998A CN108354991A CN 108354991 A CN108354991 A CN 108354991A CN 201810362998 A CN201810362998 A CN 201810362998A CN 108354991 A CN108354991 A CN 108354991A
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王晓璐
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
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    • A61K35/583—Snakes; Lizards, e.g. chameleons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/741—Probiotics
    • A61K35/744—Lactic acid bacteria, e.g. enterococci, pediococci, lactococci, streptococci or leuconostocs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/52—Juglandaceae (Walnut family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system

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  • Organic Chemistry (AREA)
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  • Medicines Containing Plant Substances (AREA)

Abstract

The invention discloses a kind of plant extracts mouth sprays and its manufacturing method for acute bronchitis, include component A, component B and riboflavin dry powder in the bronchus spray, wherein component A, which is the mass fraction group that the sufficient granularity of illumination is 1000 mesh, 1200 mesh, becomes the mixed-powder of 55 parts 60 parts of tangerine jerky, 3 parts 5 parts of hickory nut powder, 0.05 part 0.1 part of water-soluble alkali；Component B be the mass fraction composition after the activation of high energy shortwave be 20 parts 25 parts of ginsenoside R2, the mixture of 12 parts 15 parts of notoginsenoside R, 2 parts 3 parts of gecko powder, concentration 1 × 10 is also added in the mixture8cfu/ml‑1×1091 part 1.2 parts of cfu/ml α-hemolytic streptococcus microbial inoculum.Treating both manifestation and root cause of disease of the present invention, promote to absorb, promote to repair, protection bronchus, source are green, without side-effects, treatment comes into force soon.

Description

One Plant Extracts mouth sprays and its manufacturing method
Technical field
The present invention relates to pharmaceutical technology field more particularly to a kind of plant extracts oral cavity sprays for acute bronchitis Agent and its manufacturing method.
Background technology
Acute bronchitis is the bronchial mucosa inflammation caused by the pathogenic infections such as virus or bacterium.It is infant period Common disease, frequently-occurring disease, often secondary to the infection of the upper respiratory tract after, also often for pneumonia early stage show.This disease is mostly tired out simultaneously And trachea-bronchial epithelial cell, therefore proper naming should be acute tracheobronchitis.Clinic is with the companion that coughs（Or not companion）There is bronchial secretion Object, which increases, to be characterized.
Treatment generally use in the prior art, which is suited the medicine to the illness, solves disease treatment, such as uses analgesic-antipyretic（Such as：Adult gives Ah Si Woods or paracetamol；Children, which give, gives paracetamol）Alleviation does not accommodate reduction body temperature；There is phlegm or lasting height When heat and the state of an illness are heavier, antibiotic is used.To most adult patients, oral tetracycline or ampicillin, replacement therapy is optional TMP-SMX.8 years old or less children avoid with tetracycline, use Amoxicillin；It was mycoplasma pneumoniae or chlamydia pneumoniae originally such as to cause a disease, Then give erythromycin.But these medicaments be to the ill property use and mandatory alleviation symptom, and all have certain toxic side effect, Belong to the chemical synthesis for needing to be strictly controlled or extraction medicament simultaneously, in addition these medicaments also do not have rush and absorb, promote to repair Again, bronchial function is protected.
Therefore, it is badly in need of a kind for the treatment of both manifestation and root cause of disease on the market, promotees to absorb, promotees to repair, protection bronchus, source green, making without pair It is come into force the fast plant extracts mouth sprays for acute bronchitis with, treatment.
Invention content
In view of the above defects of the prior art, the present invention is intended to provide a kind for the treatment of both manifestation and root cause of disease, rush absorb, promote to repair Multiple, protection bronchus, source be green, it is without side-effects, treat the fast plant extracts oral cavity for acute bronchitis of coming into force Spray and its manufacturing method.
To achieve the goals above, the present invention uses following technical scheme：A kind of plant for acute bronchitis carries The manufacturing method of taking mouth chamber spray, includes the following steps：
1）Prepare before production
1. component A raw material prepare：Prepare 55 parts -60 parts of tangerine jerky, 3 parts -5 parts of hickory nut powder, water-soluble alkali by weight 0.05 part -0.1 part；
2. component B raw material prepare：Prepare by weight 20 parts -25 parts of ginsenoside R2,12 parts -15 parts of notoginsenoside R, 2 parts -3 parts of gecko powder；
3. auxiliary material prepares：Prepare concentration 1 × 10 by weight8cfu/ml-1×109Cfu/ml α-hemolytic streptococcus 1 part -1.2 parts of microbial inoculum, 0.02 part -0.03 part of riboflavin dry powder；
2）The manufacture of component A
1. by 1）1. component A that middle step obtains is ground to the powder of -1200 mesh granularity of 1000 mesh；
2. 1. powder that step obtains is placed in intensity of illumination 4 × 104lux-10×104Exposure -3 days 2 days is i.e. under the sunlight of lux Obtain for use component A；
3）The manufacture of component B
1. by 1）2. component B that middle step obtains uses the light wave of wavelength 300nm-320nm to continue with the light intensity of 300-500lux 4h-5h is irradiated, activation medicinal powder is obtained；
2. by the implantation stage 1 in 1. activation medicinal powder that step obtains）3. α-hemolytic streptococcus microbial inoculum that step prepares, so After be immediately placed on -20 DEG C -- refrigerated at a temperature of 40 DEG C, that is, obtain for use component B；
4）The manufacture of mouth sprays
1. by the stage 2）The for use component A obtained and stage 3）Obtain for use component B after mixing with mixture gross mass 12-15 times of pure water and stage 1）3. riboflavin dry powder blend that step prepares obtains required mouth sprays after stirring evenly；
The present invention application method be：
1. by the stage 4）Low-temperature heating device during the mouth sprays of acquisition use（Such as milk lukewarm, or it is inserted with the tepidarium of clinical thermometer Etc. daily apparatus for household use）It is heated to after 35 DEG C -40 DEG C at equably spirt oral cavity deep throat；
2. it is 1. primary to repeat step for every eight hours, continues -4 days 3 days, complete a course for the treatment of.
The plant extracts mouth sprays for acute bronchitis manufactured using the above method, in the bronchus spray Including component A, component B and riboflavin dry powder three parts, wherein component A is specially that the sufficient granularity of illumination is 1000 mesh -1200 Purpose mass fraction group becomes the mixing of 55 parts -60 parts of tangerine jerky, 3 parts -5 parts of hickory nut powder, 0.05 part -0.1 part of water-soluble alkali Powder；Component B is specially that the mass fraction composition after the activation of high energy shortwave is 20 parts -25 parts of ginsenoside R2, notoginsenoside R 12 parts -15 parts, the mixture of 2 parts -3 parts of gecko powder are also added with concentration 1 × 10 in the mixture8cfu/ml-1×109cfu/ 1 part -1.2 parts of ml α-hemolytic streptococcus microbial inoculum.
Compared with the prior art, the present invention as the above scheme is adopted, has the following advantages：（1）Different from existing skill Art largely uses the poisonous and harmful medicament that chemical synthesis or chemical industry are extracted, all components of the invention can widely to be planted from source It is extracted in object group, it is nonhazardous, without side-effects.（2）Component A is tangerine jerky and hickory nut powder, both plant extracts or plant Dry powder includes bronchial mucosa and the almost all nutrient of bronchus reparation and growth, is wherein planted containing more than 170 in tangerine meat Compounds and more than 60 plant flavone compound, and most of substances are naturals, and hickory nut powder contains albumen per hectogram 15-20 grams of matter, 10 grams of carbohydrate, and containing various trace elements and minerals such as calcium needed by human, phosphorus, iron, and The multivitamins such as carrotene, the nutrition in both certain compositions be difficult directly by buccal absorption, it is especially intact Intracavitary skin surface, but the present invention plays a role provided with three measures for component A：First item is exactly strong natural light exposure, The moisture content that can be further backing out in component A goes out except harmful microorganism, so that component A dusting is obtained more thorough；Section 2 is to utilize α-hemolytic streptococcus microbial inoculum in component B（Why it is placed in component B rather than component A is in order to avoid component A mistakes It is early to be decomposed into after active small molecular composition or excessive decomposition as low nutrition substance by microbial life reaction）, according to correlation Symbiosis can be formed with the mucus on bronchial mucosa surface by studying α-hemolytic streptococcus（α-hemolytic streptococcus is The member of human respiratory normal flora, root is it was found that people can be with A type haemolysis while suffering from nearly all breathing problem Property streptococcus flora concentration reduction, the bacterium is other than vital movement is beneficial to respiratory tract, also a important function --- inhibit Pneumococcus breeds）, it is even more especially to be enriched in the region of bronchitis affected part mucus accumulation, component A can pass through here The vital movement sustained release of α-hemolytic streptococcus resolves into small molecule and easily absorbs nutrient, therefore can promote affected part self-healing； Section 3 riboflavin, riboflavin are in vivo to promote respiratory chain energy there are many main function when acting on, but being used for the present invention It generates（It is well known that when with bronchitis, due to the consumption having difficulty in breathing with paroxysmal cough, respiratory chain energy expenditure is big Increase, therefore is highly desirable to supplement energy）, it is the activator of cellular respiration and cell metabolism.（3）Component B is in fact Chinese medicine The combination of active ingredient extract, wherein ginsenoside R2, which have, promotes bronchus from immunity, supplement vigour, notoginsenoside R1 has anti-inflammatory, analgesia immunoregulation effect, and gecko powder controls cough due to consumptive disease and lung stops up upper gas, has invigorating the lung and the kidney, gas of receiving fixed Asthma, the effect of supporing yang strengthening the essence, these three compositions each other in table, comprehensive coordination effect, it more difficult to, these three compositions all come into force It is exceedingly fast, pharmacological property is rapid and effect is notable.（4）Due to the antibacterial antivirus of present invention collection, promote from immunity, rush skin and mucosa repairing growth Comprehensive function, therefore with treating both manifestation and root cause of disease, promote to absorb, promote to repair, protection bronchus, without side-effects, treatment come into force fast skill Art effect.
Specific implementation mode
Embodiment 1：
A kind of plant extracts mouth sprays for acute bronchitis, in the bronchus spray comprising component A, component B and Riboflavin dry powder three parts, wherein component A, which are specially the mass fraction group that the sufficient granularity of illumination is -1200 mesh of 1000 mesh, to be become The mixed-powder of tangerine jerky 55g, hickory nut powder 3g, water-soluble alkali 0.05g；Component B is specially the quality after the activation of high energy shortwave Number composition is the mixture of ginsenoside R2 20g, notoginsenoside R 12g, gecko powder 2g, is also added in the mixture dense Degree 1 × 108cfu/ml-1×109Cfu/ml α-hemolytic streptococcus microbial inoculums 1g.
The manufacturing method of the above-mentioned plant extracts mouth sprays for acute bronchitis, includes the following steps：
1）Prepare before production
1. component A raw material prepare：Prepare tangerine jerky 55g, hickory nut powder 3g, sodium hydroxide 0.05g by weight；
2. component B raw material prepare：Prepare ginsenoside R2 20g, notoginsenoside R 12g, gecko powder 2g by weight；
3. auxiliary material prepares：Prepare concentration 1 × 10 by weight8cfu/ml-1×109Cfu/ml α-hemolytic streptococcus Microbial inoculum 1g, riboflavin dry powder 0.02g；
2）The manufacture of component A
1. by 1）1. component A that middle step obtains is ground to the powder of -1200 mesh granularity of 1000 mesh；
2. 1. powder that step obtains is placed in intensity of illumination 4 × 104lux-6×104Exposure is obtained and is waited for for 2 days under the sunlight of lux With component A；
3）The manufacture of component B
1. by 1）2. component B that middle step obtains uses the light wave of wavelength 300nm-320nm with the light intensity prolonged exposure of 300lux 4h obtains activation medicinal powder；
2. by the implantation stage 1 in 1. activation medicinal powder that step obtains）3. α-hemolytic streptococcus microbial inoculum that step prepares, so After be immediately placed on -20 DEG C -- refrigerated at a temperature of 40 DEG C, that is, obtain for use component B；
4）The manufacture of mouth sprays
1. by the stage 2）The for use component A obtained and stage 3）Obtain for use component B after mixing with mixture gross mass 15 times of pure water and stage 1）3. riboflavin dry powder blend that step prepares obtains required mouth sprays after stirring evenly；
5）It uses
1. by the stage 4）The mouth sprays of acquisition are heated to after 35 DEG C using milk lukewarm at equably spirt oral cavity deep throat；
2. it is 1. primary to repeat step for every eight hours, continues 3 days, complete a course for the treatment of.
The correspondence illness of the present embodiment is acute bronchitis, and clinical application effect is：Clinical Selection 60 is acute Bronochitic, with wherein 30 entitled negative controls, other 30 people are treated by the present embodiment, after a course for the treatment of, Effective 21, effective 7, total effective rate 93.3%.
Embodiment 2：
A kind of plant extracts mouth sprays for acute bronchitis, in the bronchus spray comprising component A, component B and Riboflavin dry powder three parts, wherein component A, which are specially the mass fraction group that the sufficient granularity of illumination is -1200 mesh of 1000 mesh, to be become The mixed-powder of tangerine jerky 60g, hickory nut powder 5g, water-soluble alkali 0.1g；Component B is specially the mass parts after the activation of high energy shortwave Array becomes the mixture of ginsenoside R2 25g, notoginsenoside R 15g, gecko powder 3g, and concentration is also added in the mixture 1×108cfu/ml-1×109Cfu/ml α-hemolytic streptococcus microbial inoculums 1.2g.
The manufacturing method of the above-mentioned plant extracts mouth sprays for acute bronchitis, includes the following steps：
1）Prepare before production
1. component A raw material prepare：Prepare tangerine jerky 60g, hickory nut powder 5g, sodium hydroxide 0.05g, potassium hydroxide by weight 0.05g；
2. component B raw material prepare：Prepare ginsenoside R2 25g, notoginsenoside R 15g, gecko powder 3g by weight；
3. auxiliary material prepares：Prepare concentration 1 × 10 by weight8cfu/ml-1×109Cfu/ml α-hemolytic streptococcus Microbial inoculum 1.2g, riboflavin dry powder 0.03g；
2）The manufacture of component A
1. by 1）1. component A that middle step obtains is ground to the powder of -1200 mesh granularity of 1000 mesh；
2. 1. powder that step obtains is placed in intensity of illumination 8 × 104lux-10×104Exposure is obtained and is waited for for 3 days under the sunlight of lux With component A；
3）The manufacture of component B
1. by 1）2. component B that middle step obtains uses the light wave of wavelength 300nm-320nm with the light intensity prolonged exposure of 500lux 5h obtains activation medicinal powder；
2. by the implantation stage 1 in 1. activation medicinal powder that step obtains）3. α-hemolytic streptococcus microbial inoculum that step prepares, so After be immediately placed on -20 DEG C -- refrigerated at a temperature of 40 DEG C, that is, obtain for use component B；
4）The manufacture of mouth sprays
1. by the stage 2）The for use component A obtained and stage 3）Obtain for use component B after mixing with mixture gross mass 12 times of pure water and stage 1）3. riboflavin dry powder blend that step prepares obtains required mouth sprays after stirring evenly；
5）It uses
1. by the stage 4）The mouth sprays of acquisition are heated to after 40 DEG C equably spirt oral cavity using the tepidarium for being inserted with clinical thermometer At deep throat；
2. it is 1. primary to repeat step for every eight hours, continues 4 days, complete a course for the treatment of.
The correspondence illness of the present embodiment is acute bronchitis, and clinical application effect is：Clinical Selection 60 is acute Bronochitic, with wherein 30 entitled negative controls, other 30 people are treated by the present embodiment, after a course for the treatment of, Effective 24, effective 5, total effective rate 96.7%.
The foregoing description of the disclosed embodiments, only for enabling professional and technical personnel in the field to realize or using this hair It is bright.Various modifications to these embodiments will be apparent to those skilled in the art, and determine herein The General Principle of justice can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, originally Invention is not intended to be limited to the embodiments shown herein, and is to fit to and the principles and novel features disclosed herein Consistent widest range.

Claims (3)

1. a kind of manufacturing method of plant extracts mouth sprays for acute bronchitis, it is characterised in that including following step Suddenly：
1）Prepare before production
1. component A raw material prepare：Prepare 55 parts -60 parts of tangerine jerky, 3 parts -5 parts of hickory nut powder, water-soluble alkali by weight 0.05 part -0.1 part；
2. component B raw material prepare：Prepare by weight 20 parts -25 parts of ginsenoside R2,12 parts -15 parts of notoginsenoside R, 2 parts -3 parts of gecko powder；
3. auxiliary material prepares：Prepare concentration 1 × 10 by weight8cfu/ml-1×109Cfu/ml α-hemolytic streptococcus bacterium 1 part -1.2 parts of agent, 0.02 part -0.03 part of riboflavin dry powder；
2）The manufacture of component A
1. by 1）1. grinding raw material that middle step obtains to -1200 mesh granularity of 1000 mesh powder；
2. 1. powder that step obtains is placed in intensity of illumination 4 × 104lux-10×104Exposure -3 days 2 days is i.e. under the sunlight of lux Obtain for use component A；
3）The manufacture of component B
1. by 1）2. raw material that middle step obtains use the light wave of wavelength 300nm-320nm to continue with the light intensity of 300-500lux 4h-5h is irradiated, activation medicinal powder is obtained；
2. by the implantation stage 1 in 1. activation medicinal powder that step obtains）3. α-hemolytic streptococcus microbial inoculum that step prepares, so After be immediately placed on -20 DEG C -- refrigerated at a temperature of 40 DEG C, that is, obtain for use component B；
4）The manufacture of mouth sprays
1. by the stage 2）The for use component A obtained and stage 3）Obtain for use component B after mixing with mixture gross mass 12-15 times of pure water and stage 1）3. riboflavin dry powder blend that step prepares obtains required mouth sprays after stirring evenly.
2. being used for the manufacturing method of the plant extracts mouth sprays of acute bronchitis, feature according to claim 1 It is：The water-soluble alkali is specially one kind or their compositions in sodium hydroxide, potassium hydroxide.
3. using the plant extracts mouth sprays for acute bronchitis of claim 1 the method manufacture, feature It is：Include component A, component B and riboflavin dry powder three parts in the bronchus spray, wherein component A is specially that illumination is abundant Granularity be -1200 mesh of 1000 mesh mass fraction group become 55 parts -60 parts of tangerine jerky, 3 parts -5 parts of hickory nut powder, water-soluble alkali 0.05 part -0.1 part of mixed-powder；Component B is specially that the mass fraction composition after the activation of high energy shortwave is ginsenoside R2 20 Parts -25 parts, the mixture of 12 parts -15 parts of notoginsenoside R, 2 parts -3 parts of gecko powder, be also added in the mixture concentration 1 × 108cfu/ml-1×1091 part -1.2 parts of cfu/ml α-hemolytic streptococcus microbial inoculum.
CN201810362998.8A 2018-04-21 2018-04-21 One Plant Extracts mouth sprays and its manufacturing method Pending CN108354991A (en)

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Application publication date: 20180803