CN108324931A - A kind of plant extracts nasal spray and its manufacturing method for intractable rhinitis - Google Patents

A kind of plant extracts nasal spray and its manufacturing method for intractable rhinitis Download PDF

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CN108324931A
CN108324931A CN201810362990.1A CN201810362990A CN108324931A CN 108324931 A CN108324931 A CN 108324931A CN 201810362990 A CN201810362990 A CN 201810362990A CN 108324931 A CN108324931 A CN 108324931A
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parts
component
nasal spray
plant extracts
rhinitis
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王晓璐
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/12—Ketones
    • A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
    • A61K36/346—Platycodon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/10—Preparation or pretreatment of starting material
    • A61K2236/19—Preparation or pretreatment of starting material involving fermentation using yeast, bacteria or both; enzymatic treatment

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Medicinal Chemistry (AREA)
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  • Engineering & Computer Science (AREA)
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  • Microbiology (AREA)
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  • Alternative & Traditional Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
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  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Ophthalmology & Optometry (AREA)
  • Molecular Biology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)

Abstract

The invention discloses a kind of plant extracts nasal spray and its manufacturing method for intractable rhinitis, include the plant extracts nasal spray and component C two parts for intractable rhinitis in the nasal spray；Plant extracts nasal spray for intractable rhinitis includes component A, component B and coenzyme q 10 dry, and wherein component A, which is the mass fraction group that the sufficient granularity of illumination is 1000 mesh, 1200 mesh, becomes the mixed-powder of 55 parts 60 parts of tremella gum original albumen, 3 parts 5 parts of dry Kelp Powder, 0.05 part 0.1 part of water-soluble alkali；Component B, which is the mass fraction group after the activation of high energy shortwave, becomes the mixture that water carries 20 parts 25 parts of dark plum acid, 12 parts 15 parts of Radix Platycodonis extract, 2 parts 3 parts of liquiritin, and concentration 1 × 10 is also added in the mixture8cfu/ml‑1×1091 part 1.2 parts of the excellent bacillus microbial inoculum of cfu/ml mucus.Treating both manifestation and root cause of disease of the present invention, promote to absorb, promote to repair, protection nasal cavity, source is green, without side-effects, therapeutic effect is good.

Description

A kind of plant extracts nasal spray and its manufacturing method for intractable rhinitis
Technical field
The present invention relates to pharmaceutical technology field more particularly to a kind of plant extracts nasal sprays for intractable rhinitis And its manufacturing method.
Background technology
Nasal cavity topical spray is treatment allergic rhinitis, rhinitis chronic, nasosinusitis and the postoperative common drug of nose.Due to Local application goes directly affected part, and good effect, dosage is small, few side effects.Nose spray in the prior art includes mainly three classes：Nose sprays Hormone, nose spray antihistamine and nose spray vasoconstrictor, but these three medicaments be to the ill property use and mandatory alleviation disease Shape, and all have certain toxic side effect, while belonging to the chemical synthesis for needing to be strictly controlled or extraction medicament, in addition this Three kinds of medicaments, which also do not have, to be promoted to absorb, promotees to repair, protect nasal cavity and treat the function of nasal cavity illness.
Therefore, be badly in need of on the market a kind for the treatment of both manifestation and root cause of disease, promote to absorb, promote to repair, protection nasal cavity, source are green, it is without side-effects, The good plant extracts nasal spray for intractable rhinitis of therapeutic effect.
Invention content
In view of the above defects of the prior art, the present invention is intended to provide a kind for the treatment of both manifestation and root cause of disease, rush absorb, promote to repair Multiple, protection nasal cavity, the plant extracts nasal spray for intractable rhinitis that source is green, without side-effects, therapeutic effect is good And its manufacturing method.
To achieve the goals above, the present invention uses following technical scheme：A kind of plant extract for intractable rhinitis The manufacturing method of object nasal spray, includes the following steps：
1）Prepare before production
1. component A raw material prepare：Prepare 55 parts -60 parts of white fungus collagen, 3 parts -5 parts of dry Kelp Powder, water-soluble by weight 0.05 part -0.1 part of alkali of property；
2. component B raw material prepare：Prepare water by weight and carries 20 parts -25 parts of dark plum acid, 12 parts -15 parts of Radix Platycodonis extract, sweet 2 parts -3 parts of careless glucoside；
3. auxiliary material prepares：Prepare concentration 1 × 10 by weight8cfu/ml-1×109The excellent bacillus microbial inoculum of cfu/ml mucus 1 Part -1.2 parts, 0.02 part -0.03 part of coenzyme q 10 dry；
2）The manufacture of component A
1. by 1）1. grinding raw material that middle step obtains to -1200 mesh granularity of 1000 mesh powder；
2. 1. powder that step obtains is placed in intensity of illumination 4 × 104lux-10×104Exposure -3 days 2 days is i.e. under the sunlight of lux Obtain for use component A；
3）The manufacture of component B
1. by 1）2. component B that middle step obtains uses the light wave of wavelength 300nm-320nm to continue with the light intensity of 300-500lux 4h-5h is irradiated, activation medicinal powder is obtained；
2. by the implantation stage 1 in 1. activation medicinal powder that step obtains）The 3. excellent bacillus microbial inoculum of mucus that step prepares, immediately after It is placed in -20 DEG C -- it is refrigerated at a temperature of 40 DEG C, that is, obtains for use component B；
4）The manufacture of plant extracts nasal spray for intractable rhinitis
1. by the stage 2）The for use component A obtained and stage 3）Obtain for use component B after mixing with mixture gross mass 12-15 times of pure water and stage 1）3. coenzyme q 10 dry mixing that step prepares obtains institute required to stubbornness after stirring evenly The plant extracts nasal spray of property rhinitis.
In the manufacturing method of the above-mentioned plant extracts nasal spray for intractable rhinitis, the water-soluble alkali is specially One kind in sodium hydroxide, potassium hydroxide or their compositions.
In the manufacturing method of the above-mentioned plant extracts nasal spray for intractable rhinitis, the raw material of the component B When preparation, also increase by 1 part -2 parts of asterin having by weight.
Using the plant extracts nasal spray for intractable rhinitis of above method manufacture, include in the nasal spray Component A, component B and coenzyme q 10 dry three parts, wherein component A are specially that the sufficient granularity of illumination is -1200 purpose of 1000 mesh Mass fraction group become 55 parts -60 parts of tremella gum original albumen, 3 parts -5 parts of dry Kelp Powder, 0.05 part -0.1 part of water-soluble alkali it is mixed Close powder；Component B is specially that the mass fraction group after the activation of high energy shortwave proposes 20 parts -25 parts of dark plum acid, campanulaceae extraction as water The mixture of 12 parts -15 parts of object, 2 parts -3 parts of liquiritin is also added with concentration 1 × 10 in the mixture8cfu/ml-1× 1091 part -1.2 parts of the excellent bacillus microbial inoculum of cfu/ml mucus.
The present invention application method be：
1. the pure appropriate amount of water using mass fraction containing sodium citrate 10% cleans nasal cavity；
2. low-temperature heating device in using（Such as milk lukewarm, or the daily apparatus for household use such as tepidarium for being inserted with clinical thermometer）By rank Section 4）The plant extracts nasal spray for intractable rhinitis obtained is heated to after 35 DEG C -40 DEG C equably spirt nasal cavity；
3. every 12 hours repetition steps 1.-it is 2. primary, continue -5 days 4 days, complete a course for the treatment of, be spaced after a week and repeat one and treat Journey is completed after amounting to the 3-5 courses for the treatment of all using process.
Compared with the prior art, the present invention as the above scheme is adopted, has the following advantages：（1）Different from existing skill It is poisonous and harmful that art largely uses the chemical syntheses such as nose spray hormone, nose spray antihistamine and nose spray vasoconstrictor or chemical industry to extract Medicament, all components of the invention can be extracted from the extensive flora in source, nonhazardous, without side-effects.（2）Component A is White fungus collagen and dry Kelp Powder, both plant extracts or plant drymeal include bronchia mucosal and nasal cavity skin repair and The almost all nutrient of growth, the nutrition in both certain compositions be difficult directly by nasal absorption, it is especially intact Intracavitary skin surface, but the present invention plays a role provided with three measures for component A：First item is exactly that strong natural light exposes Solarization, the moisture content that can be further backing out in component A go out except harmful microorganism, so that component A dusting is obtained more thorough；Section 2 is Utilize the excellent bacillus microbial inoculum of mucus in component B（Why it is placed in component B rather than component A is in order to avoid component A is too early Become low nutrition substance after being decomposed into active small molecular composition or excessive decomposition by microbial life reaction）, ground according to correlation Symbiosis can be formed with the mucus of nasal mucosal surface by studying carefully the excellent bacillus of mucus（Excellent bacillus is humans and animals Oral normal flora Member, wherein the excellent bacillus of mucus to body skin surface absorption of nutrient ingredients have microbial ecology balance etc. functions）, especially It is even more to be enriched in the region that rhinitis affected part mucus is accumulated, component A here can be slow by the vital movement of the excellent bacillus of mucus It releases and resolves into small molecule and easily absorb nutrient, it is well known that intact skin is seldom to extraneous Nutrients Absorption, but skin injury The autonomous nutrient absorption of the subcutaneous tissue at place is very capable, therefore can promote affected part self-healing；Section 3 is the work by ubiquinone With the autonomous nutrient absorption for promoting affected part subcutaneous tissue, ubiquinone lifting in proton displacement and electron transmission in respiratory chain in vivo It acting on, it is the activator of cellular respiration and cell metabolism, is also important antioxidant and nonspecific immunity strengthening agent, It can also play and centainly go out except affected part harmful bacteria（Such as staphylococcus aureus）Effect；The water-soluble alkali of addition and preferred Water-soluble alkali specific choice is for that component A entirety nutrition is allowed to form better nutrition system with the excellent bacillus of mucus（It adjusts It saves pH value to deviate to neutrality, because fester itself is acid）.（3）Component B is in fact the group of active Chinese drug component composition extract It closes, it is the dark plum acid extracted from dark plum using water extraction that wherein water, which carries dark plum acid, and this composition can clinically be played and be held back Superficial heat, energy air-breathing return member, the effect for promoting mucilage secretion, Radix Platycodonis extract to have relaxing tendons and activating collaterals, toxic removing, the effect of apocenosis, Radix Glycyrrhizae Glucoside has the function of anti-oxidant, antiviral, exterminating bacterium, these three compositions each other in table, comprehensive coordination effect, it more difficult to It is that these three compositions all do not have irritation, and pharmacological property is mild but effect is notable；And after preferably increasing asterin, the present invention is also Play the role of diluting nasal cavity fester, mitigate intracavitary skin irritatin, make invention come into force faster, pharmacological property milder.（4）Due to the present invention The comprehensive function for collecting antibacterial antivirus, promoting mucilage secretion, promoting skin and mucosa repairing growth, therefore there is treating both manifestation and root cause of disease, promote to absorb, promote It repairs, protection nasal cavity, technique effect without side-effects, therapeutic effect is good.
Specific implementation mode
Embodiment 1：
A kind of plant extracts nasal spray for intractable rhinitis, the interior nasal spray includes component A, component B and coenzyme Q10 dry powder three parts, wherein component A, which are specially the mass fraction group that the sufficient granularity of illumination is -1200 mesh of 1000 mesh, becomes silver The mixed-powder of ear collagen 55g, dry Kelp Powder 3g, water-soluble alkali 0.05g；Component B is specially after high energy shortwave activates Mass fraction group becomes the mixture that water carries dark plum acid 20g, Radix Platycodonis extract 12g, liquiritin 2g, is also added in the mixture Concentration 1 × 108cfu/ml-1×109The excellent bacillus microbial inoculum 1g of cfu/ml mucus.
The manufacturing method of the above-mentioned plant extracts nasal spray for intractable rhinitis, includes the following steps：
1）Prepare before production
1. component A raw material prepare：Prepare white fungus collagen 55g, dry Kelp Powder 3g, sodium hydroxide 0.05g by weight；
2. component B raw material prepare：Prepare water by weight and carries dark plum acid 20g, Radix Platycodonis extract 12g, liquiritin 2g；
3. auxiliary material prepares：Prepare concentration 1 × 10 by weight8cfu/ml-1×109The excellent bacillus microbial inoculum 1g of cfu/ml mucus, Coenzyme q 10 dry 0.02g；
2）The manufacture of component A
1. by 1）1. grinding raw material that middle step obtains to -1200 mesh granularity of 1000 mesh powder；
2. 1. powder that step obtains is placed in intensity of illumination 4 × 104lux-6×104Exposure is obtained and is waited for for 2 days under the sunlight of lux With component A；
3）The manufacture of component B
1. by 1）2. component B that middle step obtains uses the light wave of wavelength 300nm-320nm with the light intensity prolonged exposure of 300lux 4h obtains activation medicinal powder；
2. by the implantation stage 1 in 1. activation medicinal powder that step obtains）The 3. excellent bacillus microbial inoculum of mucus that step prepares, immediately after It is placed in -20 DEG C -- it is refrigerated at a temperature of 40 DEG C, that is, obtains for use component B；
4）The manufacture of plant extracts nasal spray for intractable rhinitis
1. by the stage 2）The for use component A obtained and stage 3）Obtain for use component B after mixing with mixture gross mass 15 times of pure water and stage 1）3. coenzyme q 10 dry mixing that step prepares obtains institute required to intractable after stirring evenly The plant extracts nasal spray of rhinitis；
5）It uses
1. the pure appropriate amount of water using mass fraction containing sodium citrate 10% cleans nasal cavity；
2. using controllable type milk lukewarm by the stage 4）The plant extracts nasal spray for intractable rhinitis obtained is heated to Equably spirt nasal cavity after 35 DEG C -40 DEG C；
3. every 12 hours repetition steps 1.-it is 2. primary, continue 4 days, complete a course for the treatment of, a course for the treatment of is repeated after being spaced a week, It is completed all using process after amounting to 5 courses for the treatment of.
The correspondence illness of the present embodiment is chronic and refractory rhinitis, and clinical application effect is：40 weights of Clinical Selection Patients with rhinitis is spent, with wherein 20 entitled negative controls, other 20 people are treated by the present embodiment, after five courses for the treatment of, nose Fill in substantially reduced, headache paroxysm frequency decline, insomnia is alleviated.
Embodiment 2：
A kind of plant extracts nasal spray for intractable rhinitis, the interior nasal spray includes component A, component B and coenzyme Q10 dry powder three parts, wherein component A, which are specially the mass fraction group that the sufficient granularity of illumination is -1200 mesh of 1000 mesh, becomes silver The mixed-powder of ear collagen 60g, dry Kelp Powder 5g, water-soluble alkali 0.1g；Component B is specially the matter after the activation of high energy shortwave Amount number group becomes the mixture that water carries dark plum acid 25g, Radix Platycodonis extract 15g, liquiritin 3g, is also added in the mixture dense Degree 1 × 108cfu/ml-1×109The excellent bacillus microbial inoculum 1.2g of cfu/ml mucus.
The manufacturing method of the above-mentioned plant extracts nasal spray for intractable rhinitis, includes the following steps：
1）Prepare before production
1. component A raw material prepare：Prepare white fungus collagen protein 60 g, dry Kelp Powder 5g, potassium hydroxide 0.5g, hydrogen by weight Sodium oxide molybdena 0.5g；
2. component B raw material prepare：Prepare water by weight and carries dark plum acid 25g, Radix Platycodonis extract 15g, liquiritin 3g, asterin 1.5g；
3. auxiliary material prepares：Prepare concentration 1 × 10 by weight8cfu/ml-1×109The excellent bacillus microbial inoculum of cfu/ml mucus 1.2g, coenzyme q 10 dry 0.03g；
2）The manufacture of component A
1. by 1）1. grinding raw material that middle step obtains to -1200 mesh granularity of 1000 mesh powder；
2. 1. powder that step obtains is placed in intensity of illumination 8 × 104lux-10×104Exposure is obtained and is waited for for 3 days under the sunlight of lux With component A；
3）The manufacture of component B
1. by 1）2. component B that middle step obtains uses the light wave of wavelength 300nm-320nm with the light intensity prolonged exposure of 500lux 5h obtains activation medicinal powder；
2. by the implantation stage 1 in 1. activation medicinal powder that step obtains）The 3. excellent bacillus microbial inoculum of mucus that step prepares, immediately after It is placed in -20 DEG C -- it is refrigerated at a temperature of 40 DEG C, that is, obtains for use component B；
4）The manufacture of plant extracts nasal spray for intractable rhinitis
1. by the stage 2）The for use component A obtained and stage 3）Obtain for use component B after mixing with mixture gross mass 12 times of pure water and stage 1）3. coenzyme q 10 dry mixing that step prepares obtains institute required to intractable after stirring evenly The plant extracts nasal spray of rhinitis；
5）It uses
1. the pure appropriate amount of water using mass fraction containing sodium citrate 10% cleans nasal cavity；
2. being aided with clinical thermometer by the stage 4 using tepidarium）The plant extracts nasal spray for intractable rhinitis obtained adds Heat is to equably spirt nasal cavity after 35 DEG C -40 DEG C；
3. every 12 hours repetition steps 1.-it is 2. primary, continue 5 days, complete a course for the treatment of, a course for the treatment of is repeated after being spaced a week, It is completed all using process after amounting to 3 courses for the treatment of.
The correspondence illness of the present embodiment is chronic and refractory rhinitis, and clinical application effect is：40 weights of Clinical Selection Patients with rhinitis is spent, with wherein 20 entitled negative controls, other 20 people are treated by the present embodiment, after three courses for the treatment of, nose Plug is i.e. substantially reduced, headache paroxysm frequency declines, insomnia is alleviated.
The foregoing description of the disclosed embodiments, only for enabling professional and technical personnel in the field to realize or using this hair It is bright.Various modifications to these embodiments will be apparent to those skilled in the art, and determine herein The General Principle of justice can be realized in other embodiments without departing from the spirit or scope of the present invention.Therefore, originally Invention is not intended to be limited to the embodiments shown herein, and is to fit to and the principles and novel features disclosed herein Consistent widest range.

Claims (4)

1. a kind of manufacturing method of plant extracts nasal spray for intractable rhinitis, it is characterised in that including following step Suddenly：
1）Prepare before production
1. component A raw material prepare：Prepare 55 parts -60 parts of white fungus collagen, 3 parts -5 parts of dry Kelp Powder, water-soluble by weight 0.05 part -0.1 part of alkali of property；
2. component B raw material prepare：Prepare water by weight and carries 20 parts -25 parts of dark plum acid, 12 parts -15 parts of Radix Platycodonis extract, sweet 2 parts -3 parts of careless glucoside；
3. auxiliary material prepares：Prepare concentration 1 × 10 by weight8cfu/ml-1×1091 part of the excellent bacillus microbial inoculum of cfu/ml mucus- 1.2 parts, 0.02 part -0.03 part of coenzyme q 10 dry；
2）The manufacture of component A
1. by 1）1. grinding raw material that middle step obtains to -1200 mesh granularity of 1000 mesh powder；
2. 1. powder that step obtains is placed in intensity of illumination 4 × 104lux-10×104Exposure -3 days 2 days is i.e. under the sunlight of lux Obtain for use component A；
3）The manufacture of component B
1. by 1）2. raw material that middle step obtains use the light wave of wavelength 300nm-320nm to continue with the light intensity of 300-500lux 4h-5h is irradiated, activation medicinal powder is obtained；
2. by the implantation stage 1 in 1. activation medicinal powder that step obtains）The 3. excellent bacillus microbial inoculum of mucus that step prepares, immediately after It is placed in -20 DEG C -- it is refrigerated at a temperature of 40 DEG C, that is, obtains for use component B；
4）The manufacture of plant extracts nasal spray for intractable rhinitis
1. by the stage 2）The for use component A obtained and stage 3）Obtain for use component B after mixing with mixture gross mass 12-15 times of pure water and stage 1）3. coenzyme q 10 dry mixing that step prepares obtains institute required to stubbornness after stirring evenly The plant extracts nasal spray of property rhinitis.
2. being used for the manufacturing method of the plant extracts nasal spray of intractable rhinitis according to claim 1, feature exists In：The water-soluble alkali is specially one kind or their compositions in sodium hydroxide, potassium hydroxide.
3. being used for the manufacturing method of the plant extracts nasal spray of intractable rhinitis according to claim 1, feature exists In：When the raw material of the component B prepare, also increase by 1 part -2 parts of asterin having by weight.
4. using the plant extracts nasal spray for intractable rhinitis of claim 1 the method manufacture, feature exists In：Include component A, component B and coenzyme q 10 dry three parts in the nasal spray, wherein component A is specially the sufficient grain of illumination Degree, which is the mass fraction group of -1200 mesh of 1000 mesh, becomes 55 parts -60 parts of tremella gum original albumen, 3 parts -5 parts of dry Kelp Powder, water solubility The mixed-powder that 0.05 part -0.1 part of alkali；Component B is specially that the mass fraction group after the activation of high energy shortwave carries dark plum acid as water 20 parts -25 parts, the mixture of 12 parts -15 parts of Radix Platycodonis extract, 2 parts -3 parts of liquiritin, be also added in the mixture concentration 1 × 108cfu/ml-1×1091 part -1.2 parts of the excellent bacillus microbial inoculum of cfu/ml mucus.
CN201810362990.1A 2018-04-21 2018-04-21 A kind of plant extracts nasal spray and its manufacturing method for intractable rhinitis Withdrawn CN108324931A (en)

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Application Number Priority Date Filing Date Title
CN201810362990.1A CN108324931A (en) 2018-04-21 2018-04-21 A kind of plant extracts nasal spray and its manufacturing method for intractable rhinitis

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Application publication date: 20180727