CN101053602A - Medicine for treating oral ulcer and its preparing method - Google Patents
Medicine for treating oral ulcer and its preparing method Download PDFInfo
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- CN101053602A CN101053602A CN 200710065834 CN200710065834A CN101053602A CN 101053602 A CN101053602 A CN 101053602A CN 200710065834 CN200710065834 CN 200710065834 CN 200710065834 A CN200710065834 A CN 200710065834A CN 101053602 A CN101053602 A CN 101053602A
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Abstract
The invention discloses a medicine for treating mouth ulcer. The primary material of the medicine is saxifrage which can combine with other plants. Said other plants are selected from one or more paddy, pricklyash peel, corn mint, and blumea balsamifera Dc or their mixture. The weight ratio of the saxifrage to other plants is 1:100-100:1. The inventive medicine has a curative effect to the mouth off-flavor generated by mouth microbe community and traumatic ulcer, mouth ulcer generated by the virus or bacteria injury and also can be used for recrudescence mouth ulcer, lichen planus generated by unknown reasons and autoimmune.
Description
Technical field
The invention belongs to the field of Chinese medicines, more particularly, the present invention relates to the vegetable Chinese herbal medicine is the medicine of the treatment oral ulcer made of primary raw material.Simultaneously, the invention still further relates to the preparation method of described medicine.
Background technology
Oral ulcer is a kind of common disease.Because the oral cavity is the starting point of human body alimentary canal, be subjected to various pathogenic bacterias, virus and mechanical external force infringement easily.Modal is exactly that oral mucosa is impaired, causes oral ulcer, festers, and the lighter influences normal digestive function, weight person even cause such as major diseases such as cancerations.
In the prior art, the Chinese medicine of treatment oral ulcer has two kinds of local application and oral medicine, local application such as JINHOUJIAN PENWUJI, BINGPENG SAN, SHANGLIAOHOUFENG SAN etc., but though these medicine respite symptoms, but also cause the bitter picotement in oral cavity, uncomfortable, and can not effect a radical cure.And oral medicine often all is antipyretic and antidotal type, and specific aim is not strong, also digestive tract is had strong stimulation, causes diarrhoea easily, and the people who suffers from indiestion, especially anemia of pregnant woman, child just can not take.
Summary of the invention
The objective of the invention is at the deficiencies in the prior art, the medicine of a kind of determined curative effect, treatment oral ulcer applied widely, safe in utilization, with low cost is provided.
Another object of the present invention provides the preparation method of this medicine.
Purpose of the present invention is achieved by following technical proposals.
* except as otherwise noted, the percent that is adopted among the present invention is percetage by weight.
The invention provides a kind of medicine for the treatment of oral ulcer, the primary raw material that it is characterized in that this medicine is Herba Saxifragae (Saxifraga stolonifera (L.) Meerb.), and adopts following method to produce:
(1) gets dry medical material of Herba Saxifragae Herb or bright product, through pulverizing or cutting;
(2) add entry, the weight ratio of medical material and water is 1～5: 25;
(3) add Sal, the weight ratio of Sal and water is 1～1.5: 100, fully stirs evenly;
(4) soaked 36～60 hours, filter; Filtrate is required Herba Saxifragae extracting solution.
The present invention adds 0.5%～1% sodium benzoate in the Herba Saxifragae extracting solution, 0.1%～0.2% nipagin ester fully stirs evenly and makes its dissolving, further makes the Herba Saxifragae medicinal liquid.The Herba Saxifragae medicinal liquid adopts conventional method to make the oral medicinal dosage form of any routine.For example:
Medicament 1---get Herba Saxifragae medicinal liquid 20L, use the cillin bottle packing, every bottle of 20ml.
Medicament 2---get Herba Saxifragae medicinal liquid 5L, with 900 infiltrations of medical gauze (5 * 5cm, bilayer), packing, 50 every bag.
Medicament 3---get Herba Saxifragae medicinal liquid 5L, with 500 infiltrations of medical cotton ball, packing (50 every bottle).
Medicament 4---(12 * 6cm) 1000, every soaks into plastic bag packing (1 every bag) with 8ml Herba Saxifragae medicinal liquid to get non-woven fabrics.
Medicament 5---get extracting solution 1L, make spray or aerosol (every bottle of 10ml).
In order to reach better therapeutic, medicine of the present invention also can with other plant society, described other plant is selected from a kind of in Oryza glutinosa (Oryza sativa L.), Pericarpium Zanthoxyli (Zanthoxylum bungeanum Maxim.), Herba Menthae (Mentha haplocalyx Briq.), the Herba Blumeae Balsamiferae (Blumea balsamifera DC.) or their mixture.Wherein, the weight ratio of Herba Saxifragae and other plant is 1: 100～100: 1, and its preferred weight ratio is 1: 100～20: 100, and optimum weight ratio is 5: 100.
If also add other plant component, the preparation method of medicine of the present invention comprises the following steps:
(1) gets Herba Saxifragae and other plant, pulverize; Add and extract solvent, the consumption that extracts solvent is 1 part～100 parts of medical material amount by weight; Be preferably 1 part: 10 parts; Leaching filters to get filtrate;
(2) filtrate to be condensed into proportion be 1.05～1.10 extractum or reclaim and extract solvent and make dry extract;
(3) extractum of gained (or dry extract) can adopt conventional method to be prepared into the oral cavity dosage form of any routine.For example emulsion, gel, solid or the aerosol of water formulation, emulsion (Water-In-Oil O/W or oil-in-water W/O) type.The form that this ingredients can powder, allow on wet cloth, washing liquid or liniment, paste or other any dental care medicines exists and uses; Wherein spray, aerosol or washing liquid are preferred forms.But these can not be used to limit protection scope of the present invention.
Wherein, the described extraction solvent of step (1) is selected from a kind of in water, 75% ethanol or 40% acetone or their mixture; Can add clinical medicine in the extractum of step (2) allows antiseptic or antibacterial, the acid adjustment of using or transfers alkali liquor, aromatic, excipient, dispersion diluent, toner, stabilizing agent, thickening agent, radiation quencher, surfactant and other known conventional adjuvant.
Extracting mode in the step (2) can be immersion, percolation or reflux; Be preferably soak at room temperature or heat warm macerating down at 50 ℃; The way of recycling of extracting solvent can adopt heating evaporation, concentrating under reduced pressure, lyophilization, spray drying; Preferably freeze drying or 60 ℃ of concentrating under reduced pressure.
Compared with prior art, the present invention has following beneficial effect:
1. determined curative effect, wide accommodation, the oral ulcer that halitosis (stink) treatment that oral microbial community imbalance and traumatic ulcer are caused and virus, antibacterial (herpesvirus, coccus, candidiasis, tulase), wound cause all has excellent curative; Also can be used for the recurrent oral ulceration that unknown cause and autoimmune cause, the treatment of lichen planus.
2. product is pure Chinese medicinal preparation, and is non-stimulated to oral mucosa, and safety is good.Can be antibiotic, antiinflammatory, pain relieving, and can very fast reparation ulcer, directly external acts on affected part, absorbs soon, has no side effect.On probation through for many years, total effective rate reaches more than 97%.Raw material sources are abundant, and manufacture method is simple, and is with low cost.Be fit to extensively promote.
In order to verify therapeutic effect of the present invention, the present invention has carried out the clinical observation of system, and relevant situation is summarized as follows:
Patient profile: 201 examples, male's 105 examples wherein, women's 96 examples, patient age 10～68 years old.
Usage and dosage: adopt preparation to be used for corresponding position outward according to different symptoms.
Criterion of therapeutical effect: recovery from illness---malaise symptoms disappears, and physical recovery is normal;
Produce effects---cardinal symptom disappears substantially, obviously improves;
Taking a turn for the better---cardinal symptom disappears, and certain improvement is arranged;
Invalid---cardinal symptom does not have improvement.
The oral ulcer symptom is a lot, and the present invention sees the following form to the curative effect of common disease type.
| Symptom | Total routine number | Recovery from illness (example) | Significantly (example) | Take a turn for the better (example) | Invalid (example) | Total effective rate (%) |
| Recurrent oral ulceration | 71 | 49 | 15 | 7 | 0 | 100.0 |
| Intractable oral cavity ulcer | 31 | 28 | 1 | 1 | 1 | 96.8 |
| Oral lichen planus | 12 | 9 | 1 | 1 | 1 | 91.7 |
| The oral microbial community imbalance | 10 | 8 | 2 | 0 | 0 | 100.0 |
| The microbial oral ulcer of beads | 15 | 12 | 2 | 0 | 1 | 93.3 |
| Halitosis | 5 | 3 | 1 | 1 | 0 | 100.0 |
| The acute herpetic stomatitis | 11 | 6 | 3 | 1 | 1 | 90.9 |
| The chemotherapy oral ulcer | 32 | 30 | 2 | 0 | 0 | 100.0 |
| The oral mucosa that wound causes is had a liking for | 14 | 11 | 0 | 2 | 1 | 92.8 |
| Acid ulcer |
With Drug therapy 201 examples of the present invention, 156 examples of fully recovering, remarkable 27 examples, 13 examples that take a turn for the better, invalid 5 examples, cure rate 77.6%, total effective rate are 97.5%.
The clinical observation patient does not all have the obvious toxic-side effects reaction.All can tolerate for discomfort after the medication, all patients adhere to that all finish medication to the course of treatment.
The specific embodiment
By specific embodiment given below and typical Application Example, can further be well understood to the present invention.But they are not the qualification to protection domain of the present invention.
Preparation embodiment 1
Get the dry medical material 2kg of Herba Saxifragae Herb (or bright product 10.0kg), pulverize (or cutting), add entry 50L, add 0.5 kilogram of Sal, fully stir evenly, soaked 48 hours, filter, add sodium benzoate 250g, nipagin ester 50g in the filtrate, fully mixing makes dissolving.
Medicament 1: taking liquid 20L, use the cillin bottle packing, every bottle of 20ml.
Medicament 2: get filtrate 5L, with 900 infiltrations of medical gauze (5 * 5cm, bilayer), packing (50 every bag).
Medicament 3: get filtrate 5L, with 500 infiltrations of medical cotton ball, packing (50 every bottle).
Medicament 4: (12 * 6cm) 1000, every soaks into plastic bag packing (1 every bag) with 8ml filtrate to get non-woven fabrics.
Medicament 5: get filtrate 1L, make spray or aerosol (every bottle of 10ml).
Preparation embodiment 2
Get the bright product 10.0kg of Herba Saxifragae Herb, Oryza glutinosa 1.0kg, Pericarpium Zanthoxyli 0.6kg, mixing is pulverized, and adds entry 50L, add Sal 0.5kg, fully stir evenly, soaked 48 hours, filter, add sodium benzoate 250g, nipagin ester 50g in the filtrate, fully mixing makes dissolving.According to carrying out packing among the preparation embodiment 1, promptly.
Preparation embodiment 3
Get the bright product 10.0kg of Herba Saxifragae Herb, Oryza glutinosa 1.0kg, Pericarpium Zanthoxyli 0.6kg, mixing is pulverized, and adds entry 40L, adds Sal 0.5kg, fully stirs evenly, and soaks 48 hours, filters filtrate for later use; Other gets 2 kilograms of Herba Blumeae Balsamiferae medical materials, uses steam distillation, collects distillate 10L, adds in the aforementioned filtrate, adds sodium benzoate 250g, nipagin ester 50g, and fully mixing makes dissolving.According to carrying out packing among the embodiment one, promptly.
Preparation embodiment 4
Get the bright product 5.0kg of Herba Saxifragae Herb, cutting adds entry 30L, fully stirs evenly, and soaks 48 hours, filters, and gets filtrate.According to carrying out packing among the embodiment one, products obtained therefrom (nuclear) radiation or high temperature sterilize, promptly.
Preparation embodiment 5
Get 2 kilograms of the bright product 10.0kg of Herba Saxifragae Herb, Pericarpium Zanthoxyli 0.6kg, Herba Blumeae Balsamiferae medical materials, mixing is pulverized, and adds entry 100L, uses steam distillation, collects distillate 50L.According to carrying out packing among the embodiment one, products obtained therefrom (nuclear) radiation or high temperature sterilize, promptly.
Application Example 1
The man, 39 years old, 3 place's ulcer appearred in tongue body left side, patient oral cavity, Sublingual, left cheek.Heavy when light during ulcer, disease opinion repeatedly shows effect: left side headache as acupuncture, the irritated insomnia, and 5 place's ulcer differ in size in the oral cavity, a maximum 16mm * 16mm of place, reckling 4mm * 4ram, the surface is covered with white pseudomembrane, little on every side red, ulcer pain is obvious, meets caloric stimulation and increases the weight of.The body of the tongue purple is dim, and tongue is greasy in vain, deep and stringy pulse.Diagnosis: intractable oral cavity ulcer.This patient adopts medicament 2 treatments: gets one on the gauze that speckles with medicinal liquid and places mouthful preceding 2 centimeters, use a mouthful air-breathing expiration repeatedly, and each 3～5 minutes, every day 4～6 times.Ulcer surface was both painless after 48 hours, recovery from illness after 4 days.
Application Example 2
The woman, 58 years old, left cheek discomfort in the oral cavity at first, coarse, pain involves right cheek later on, and feed is met savoury pain and is increased the weight of, once with multivitamin and antibiotic etc., DeGrain.Cheeks portion ulcer is surplus half a year in the oral cavity.Diagnosis: oral lichen planus.This patient's with medicament 4 and medicament 1 treatment: get the non-woven fabrics plug ulcer buccal in the left and right sides in the oral cavity that speckles with medicinal liquid, each 10 minutes, every day 4～6 times, next day, pain promptly weakened, and was painless after 4 days; Use medicament 1 (with eliminating cold for resuscitation water 1: 10 dilution) instead and gargle, every day 4～6 times every day, each 1～3 minute.Recovery from illness after 7 days.
Application Example 3
The man, 68 years old, swell and ache repeatedly in the same position of left cheek film March continuously, oral voluntarily amoxicillin, antibiotic medicine such as cefradine, pain is alleviated to some extent.The abscess portion pus that punctures out, pus are through antibacterial culturing, and the result is for corroding the Aitken bacterium.Diagnosis a: left side, bacterial oral cavity cheek film abscess.This patient's with medicament 3 and medicament 1 treatment: get the cotton balls that speckles with medicinal liquid and place the abscess of mouth place, each 10 minutes, with medicament 1 (with the dilution in 1: 10 of eliminating cold for resuscitation water) was gargled each 1～3 minute then.Every day 3～5 times.Recovery from illness after 7 days.
Application Example 4
The man, 10 years old, oral cavity pain can not be taken food, the ulcer surface of size as the oral mucosa or the tip of the tongue, visible 1 to several pieces Semen Sesamis of lingual surface.The oral secretion plate coating checking candidiasis positive.Diagnosis: the microbial oral ulcer of beads.These patient's with medicament 5 treatments: with medicament 5 spout intracavity ulcer places, every day 4～6 times, spray 4～6 times at every turn.Recovery from illness after 4 days.
Application Example 5
The woman, 29 years old, oral mucosal injury had the burning pain of poliosis, and assassination swashs that the pain increased, and influence is spoken and feed.No General Symptoms, the course of disease is from limitting about 1～2 all spontaneous recovery, but outbreak repeatedly.Diagnosis: the recurrent oral ulceration that the imbalance of exempting from service causes.These patient's with medicament 2 treatments: get one on the gauze that speckles with medicinal liquid and place mouth to go out for preceding 2 centimetres, use a mouthful air-breathing expiration repeatedly, each 3～5 minutes, every day 4～6 times.Ulcer surface was both painless after 24 hours, recovery from illness after 3 days.
Application Example 6
The man, 30 years old, margo lateralis linguae position ulcer.Ulcer outward appearance performance boundary clear, the little protuberance in edge, the no pseudomembrane in surface exists, ulcer is cerise, slightly turns white on every side.Diagnosis: the oral mucosa that wound causes is had a liking for sour ulcer.These patient's with medicament 2 treatments: get one on the gauze that speckles with medicinal liquid and place mouth to go out for preceding 2 centimetres, use a mouthful air-breathing expiration repeatedly, each 3～5 minutes, every day 4～6 times.Ulcer surface was both painless after 48 hours, recovery from illness after 4 days.
Application Example 7
The woman, 2 years old, early stage in gums, lip, the exanthema vesiculosum of single or cluster appears in position oral mucosa such as tongue, cheek, diameter 2～3mm, coated with the yellow-white pseudomembrane, the film back that comes off forms ulcer.Mainly show as stomatalgia, sialorrhea, refusing to eat, keep crying.Diagnosis: herpes simplex virus I-type infects the acute herpetic stomatitis that causes.These patient's with medicament 5 treatments: with medicament 5 spout intracavity ulcer places, every day 4～6 times, spray 4～6 times at every turn.Recovery from illness after 4 days.
Application Example 8
The man, 37 years old, halitosis.Obvious ulcer, wound are not seen in the oral cavity, brush teeth that it is hemorrhage not see, tooth is intact, does not see dental caries.Oneself's random thoughts halitosis, other people feel that abnormal flavour is obvious, for a long time in this way.Patient's with medicament 1 is gargled every day 3～5 times, each 1 minute after diluting (1: 10) with eliminating cold for resuscitation water.Halitosis is eliminated after 10 days.
* above-mentioned each case all adopts the Herba Saxifragae preparation to be used for corresponding position outward, and symptom is eased in a short time, and the oral anomaly situation disappears automatically, follows up a case by regular visits to and does not see recurrence.
Claims (8)
1. medicine for the treatment of oral ulcer is characterized in that the primary raw material medicine of this medicine is a Herba Saxifragae, and adopts following method to produce:
(1) gets dry medical material of Herba Saxifragae Herb or bright product, through pulverizing or cutting;
(2) add entry, the weight ratio of medical material and water is 1～5: 25;
(3) add Sal, the weight ratio of Sal and water is 1～1.5: 100, fully stirs evenly;
(4) soaked 36～60 hours, filter; Filtrate is required Herba Saxifragae extracting solution.
2. medicine according to claim 1 is characterized in that further being included in and adds 0.5%～1% sodium benzoate in the described Herba Saxifragae extracting solution, and 0.1%～0.2% nipagin ester fully stirs evenly and makes its dissolving, makes the Herba Saxifragae medicinal liquid.
3. medicine according to claim 1 is characterized in that described crude drug also has other plant, and described other plant is selected from a kind of in Oryza glutinosa, Pericarpium Zanthoxyli, Herba Menthae, the Herba Blumeae Balsamiferae or their mixture; Wherein, the weight ratio of Herba Saxifragae and other plant is 1: 100～100: 1.
4. medicine according to claim 3, the weight ratio that it is characterized in that Herba Saxifragae and other plant is 1: 100～20: 100;
5. medicine according to claim 4, the weight ratio that it is characterized in that Herba Saxifragae and other plant is 5: 100.
6. the preparation method of claim 3,4 or 5 described medicines is characterized in that this method comprises the following steps:
(1) gets Herba Saxifragae and other plant, pulverize; Add and extract solvent, the consumption that extracts solvent is 1 part～100 parts of medical material amount by weight; Be preferably 1 part: 10 parts; Leaching filters to get filtrate;
(2) filtrate to be condensed into proportion be 1.05～1.10 extractum or reclaim and extract solvent and make dry extract;
(3) extractum of gained or dry extract can adopt conventional method to be prepared into the oral cavity dosage form of any routine.
7. process for preparing medicine according to claim 6 is characterized in that the described extraction solvent of step (1) is selected from a kind of in water, 75% ethanol or 40% acetone or their mixture.
8. process for preparing medicine according to claim 6 is characterized in that can adding in the described extractum of step (2) clinical medicine and allows antiseptic or antibacterial, the acid adjustment of using or transfer alkali liquor, aromatic, excipient, dispersion diluent, toner, stabilizing agent, thickening agent, radiation quencher, surfactant and other known conventional adjuvant.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100658340A CN101053602B (en) | 2007-04-25 | 2007-04-25 | Medicine for treating oral ulcer and its preparing method |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2007100658340A CN101053602B (en) | 2007-04-25 | 2007-04-25 | Medicine for treating oral ulcer and its preparing method |
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| Publication Number | Publication Date |
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| CN101053602A true CN101053602A (en) | 2007-10-17 |
| CN101053602B CN101053602B (en) | 2010-12-01 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN2007100658340A Expired - Fee Related CN101053602B (en) | 2007-04-25 | 2007-04-25 | Medicine for treating oral ulcer and its preparing method |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101833613A (en) * | 2010-06-04 | 2010-09-15 | 中国科学院青岛生物能源与过程研究所 | Oral microbial community database and application thereof |
| CN102698068A (en) * | 2012-07-02 | 2012-10-03 | 张秀香 | Preparation method for oral nursing solution for preventing oral mucositis caused by chemotherapy |
| CN103751245A (en) * | 2013-12-19 | 2014-04-30 | 上海中医药大学附属岳阳中西医结合医院 | Chinese medicinal composition for treating skin diseases and its use |
-
2007
- 2007-04-25 CN CN2007100658340A patent/CN101053602B/en not_active Expired - Fee Related
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101833613A (en) * | 2010-06-04 | 2010-09-15 | 中国科学院青岛生物能源与过程研究所 | Oral microbial community database and application thereof |
| CN102698068A (en) * | 2012-07-02 | 2012-10-03 | 张秀香 | Preparation method for oral nursing solution for preventing oral mucositis caused by chemotherapy |
| CN103751245A (en) * | 2013-12-19 | 2014-04-30 | 上海中医药大学附属岳阳中西医结合医院 | Chinese medicinal composition for treating skin diseases and its use |
| CN103751245B (en) * | 2013-12-19 | 2016-04-06 | 上海中医药大学附属岳阳中西医结合医院 | One treats dermopathic Chinese medicine composition and uses thereof |
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| Publication number | Publication date |
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| CN101053602B (en) | 2010-12-01 |
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Assignee: KUNMING SINOWAY NATURAL PHARMACEUTICALS Co.,Ltd. Assignor: KUNMING LAIZHANG PHARMACEUTICAL Co.,Ltd. Contract record no.: 2011530000071 Denomination of invention: Stomatocace therapeutic pharmaceutical and its preparation method Granted publication date: 20101201 License type: Exclusive License Open date: 20071017 Record date: 20110905 |
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