CN1883529A - A pharmaceutical composition for treating cardiovascular and cerebrovascular disease and preparation method thereof - Google Patents
A pharmaceutical composition for treating cardiovascular and cerebrovascular disease and preparation method thereof Download PDFInfo
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- CN1883529A CN1883529A CNA2006100873963A CN200610087396A CN1883529A CN 1883529 A CN1883529 A CN 1883529A CN A2006100873963 A CNA2006100873963 A CN A2006100873963A CN 200610087396 A CN200610087396 A CN 200610087396A CN 1883529 A CN1883529 A CN 1883529A
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Abstract
The invention relates to a Chinese medicinal composition and process for preparation, wherein the composition is prepared from cow-bezoar 2-10 parts, borneol 20-60 parts, notoginseng 0-80 parts, and ginseng 0-80 parts, and can be prepared into dosage forms including tablets, hard capsules, soft capsules, granules, powders, pills and drop pills.
Description
(1) technical field
The present invention relates to a kind of Chinese medicine composition, the effect that this Chinese medicine composition has supporting vital QI to relieve the primary cause of disease, blood circulation promoting and blood stasis dispelling, eliminates phlegm for resuscitation, be used for obstruction of qi in the chest and cardialgia, uncomfortable in chest, chest pain, shortness of breath and palpitation, coronary heart disease, angina pectoris, myocardial infarction, apoplectic coma, cerebral hemorrhage, cerebral thrombosis brain, apoplectic hemiplegia, coma, obnubilation, encephalitis, toxic encephalopthy, heating card and see the pharmaceutical preparation of above-mentioned performance, and the preparation method of this pharmaceutical preparation.
(2) background technology
Cardiovascular and cerebrovascular disease is common ailment of middle-aged and old, frequently-occurring disease, and World Health Organization (WHO) is called " at present and in following 20 years the human No.1 killer who causes death, disables ".This Chinese medicine composition is that the inventor is according to nearly 40 years clinical experience, on the basis of secret prescription handed down in the family from generation to generation, in conjunction with the pharmaceutical preparation of modern production technology innovation and creation.The modern Chinese medicine pharmaceutical research has also confirmed that this pharmaceutical preparation has coronary artery dilating, heart tonifying, reduction blood stickiness and improves unusual functions such as hemorheology index.
(3) summary of the invention
[problem that will solve]
One of purpose of the present invention provides a kind of Chinese medicine composition for the treatment of cardiovascular and cerebrovascular disease, and this Chinese medicine composition can effectively be treated cardiovascular and cerebrovascular disease, and toxic and side effects is little.
Another object of the present invention provides the prescription and the preparation method of this Chinese medicine composition.
[technical scheme]
The inventor thinks that through clinical practice for many years the basic pathogenesis of cardiovascular and cerebrovascular disease is that the motive is lost void, insufficiency of vital energy and blood, coagulation of QI-blood, blocking barrier.Therefore treating cardiovascular and cerebrovascular disease must supporting vital QI to relieve the primary cause of disease, blood circulation promoting and blood stasis dispelling, eliminate phlegm for resuscitation.The motive a little less than, head heavily sets upright; Blood stasis is a disease, must be noted that the blood-activating and qi-promoting blood stasis dispelling; When the human righteousness is strong, can eliminating evil poison be main also.Because of the time different, be basic but set upright, be crucial.Set upright key at reinforcing the heart gas, liver controlling conveyance and dispersion, store blood is had one's ideas straightened out in order, and its China is at pawl; The kidney being the origin of congenital constitution, and main bone is given birth to marrow; The liver blood abundance can transfer kidney essense to, and kidney essense completely is full of also can turn to liver blood, so can reach nourishing YIN and invigorating YANG by invigorating the liver and kidney, the purpose of treatment cardiovascular and cerebrovascular disease.Therefore be this with the revisal, eliminating evil is to want, and blood circulation promoting and blood stasis dispelling is auxilliary, then the autonomy of heart and brain arthromyodynia.Therefore the Chinese medicine composition that uses following prescription 1 to form:
Calculus Bovis 2-10 part Borneolum Syntheticum 20-60 part Radix Notoginseng 0-80 part Radix Ginseng 0-80 part.
Calculus Bovis in the prescription comprises natural Calculus Bovis and artificial Calculus Bovis, Calculus Bovis cultivating, In vitro cultured Calculus Bovis; Radix Ginseng comprises Radix Ginseng, wild ginseng, Park Ginseng, Korean Ginseng and Radix Panacis Quinquefolii.
Wherein Radix Ginseng, Radix Notoginseng QI invigorating heart tonifying, invigorating blood circulation is monarch drug; Clear away heart-fire, detoxify, eliminate phlegm for resuscitation, cool liver endogenous wind stopping is ministerial drug; Have one's ideas straightened out refreshment, pain relieving of Borneolum Syntheticum is adjuvant drug.
One of purpose of the present invention is also to provide the prescription 2 of the Chinese medicine composition of treatment cardiovascular and cerebrovascular disease to be:
Calculus Bovis 8-10 part Borneolum Syntheticum 20-40 part Radix Notoginseng 10-80 part Radix Ginseng 10-80 part.
One of purpose of the present invention is also to provide the prescription 3 of the Chinese medicine composition of treatment cardiovascular and cerebrovascular disease to be:
Calculus Bovis 8-10 part Borneolum Syntheticum 20-40 part Radix Notoginseng 10-80 part.
One of purpose of the present invention is also to provide the prescription 4 of the Chinese medicine composition of treatment cardiovascular and cerebrovascular disease to be:
Calculus Bovis 8-10 part Borneolum Syntheticum 20-40 part Radix Ginseng 10-80 part.
The present invention also provides the Chinese medicine composition pharmaceutical preparation tablet of this treatment cardiovascular and cerebrovascular disease, hard capsule, soft capsule, granule, powder, pill, drop pill, dry suspension, suspensoid, mixture, oral liquid, oral solution, Emulsion, syrup, medicated wine, tincture, medicinal tea, distillate medicinal water, liniment, lotion, suppository, varnish, ointment, ointment, gel, transdermal patch, emplastrum, plaster, lozenge, fluid extract, extractum, soft extract, colloid, the preparation method of membrane pharmaceutical preparation:
Preparation method 1: according to above-mentioned prescription 1 or 2 described pharmaceutical preparatioies; the preparation method that it is characterized in that said pharmaceutical preparation is: above four Chinese medicine material; Radix Ginseng; Radix Notoginseng powder is broken into coarse powder; with 60%～95% alcohol reflux secondary, each 0.5～3 hour, extract fully; merge extractive liquid; filter, filtrate recycling ethanol, and continue to be concentrated into the clear paste of relative density 1.20～1.25 (60 ℃ of surveys); mix a small amount of kieselguhr; (80 ℃) drying under reduced pressure, and be ground into fine powder, with fine powder alcohol reflux secondary; each 1 hour; put cold back and filter, filtrate recycling ethanol also continues to be concentrated into the clear paste of relative density 1.20～1.35 (60 ℃ of surveys), with all the other Calculus Boviss; the Borneolum Syntheticum mixing; all be ground into impalpable powder; according to the Chinese medicine preparation general rule, make various form of Chinese drug, promptly.
Preparation method 2:, it is characterized in that the preparation method of said pharmaceutical preparation is according to above-mentioned prescription 1 or 2 described pharmaceutical preparatioies: above four Chinese medicine material, Radix Ginseng, Radix Notoginseng powder are broken into coarse powder; with 60%～95% alcohol reflux secondary, each 0.5～3 hour, extract fully; merge extractive liquid; filter, filtrate recycling ethanol, and continue to be concentrated into relative density and all the other Calculus Boviss, Borneolum Syntheticum mixing; all be ground into impalpable powder; according to the Chinese medicine preparation general rule, make various form of Chinese drug, promptly.
Preparation method 3:, it is characterized in that the preparation method of said pharmaceutical preparation is according to above-mentioned prescription 3 or 4 described pharmaceutical preparatioies: above three flavor medical materials, the Radix Ginseng powder is broken into coarse powder; with 60%～95% ethanol percolate extraction, extract fully merge extractive liquid; filter; filtrate recycling ethanol, and continue to be concentrated into the clear paste of relative density 1.20～1.35 (60 ℃ of surveys), with all the other Calculus Boviss, Borneolum Syntheticum mixing; all be ground into impalpable powder; according to the Chinese medicine preparation general rule, make various form of Chinese drug, promptly.
Preparation method 4: according to above-mentioned prescription 3 or 4 described pharmaceutical preparatioies; the preparation method that it is characterized in that said pharmaceutical preparation is: above three flavor medical materials; Radix Ginseng or Radix Notoginseng powder are broken into coarse powder; with 60%～95% alcohol reflux secondary, each 0.5～3 hour, extract fully; merge extractive liquid; filter, filtrate recycling ethanol, and continue to be concentrated into the clear paste of relative density 1.20～1.25 (60 ℃ of surveys); mix a small amount of kieselguhr; (80 ℃) drying under reduced pressure, and be ground into fine powder, with fine powder alcohol reflux secondary; each 1 hour; put cold back and filter, filtrate recycling ethanol also continues to be concentrated into the clear paste of relative density 1.20～1.35 (60 ℃ of surveys), with all the other Calculus Boviss; the Borneolum Syntheticum mixing; all be ground into impalpable powder; according to the Chinese medicine preparation general rule, make various form of Chinese drug, promptly.
Preparation method 5: according to above-mentioned prescription 3 or 4 described pharmaceutical preparatioies; the preparation method that it is characterized in that said pharmaceutical preparation is: above three flavor medical materials; Radix Ginseng or Radix Notoginseng powder are broken into coarse powder; with 60%～95% alcohol reflux secondary, each 0.5～3 hour, extract fully; merge extractive liquid; filter, filtrate recycling ethanol, and continue to be concentrated into the clear paste of relative density 1.20～1.25 (60 ℃ of surveys); mix a small amount of kieselguhr; (80 ℃) drying under reduced pressure, and be ground into fine powder, with fine powder and Calculus Bovis alcohol reflux secondary; each 1 hour; put cold back and filter, filtrate recycling ethanol also continues to be concentrated into the clear paste of relative density 1.20～1.35 (60 ℃ of surveys), with the Borneolum Syntheticum mixing; all be ground into impalpable powder; according to the Chinese medicine preparation general rule, make various form of Chinese drug, promptly.
(4) specific implementation method
Embodiment one
Embodiment 1: the method for preparing this pharmaceutical preparation tablet:
The first step: with preparation method 1-5
Second step: add an amount of adjuvant as starch, dextrin, sucrose, microcrystalline Cellulose, hyprolose, methylcellulose, ethyl cellulose, Carboxymethyl cellulose sodium, silicon dioxide, aluminium hydroxide, ethanol, mixing, make the various tablets under the Chinese Pharmacopoeia tablet item, packing, promptly.
Embodiment 2: the method for preparing this pharmaceutical preparation capsule:
The first step: with preparation method 1-5
Second step: add an amount of adjuvant as starch, dextrin, sucrose, microcrystalline Cellulose, hyprolose, methylcellulose, ethyl cellulose, Carboxymethyl cellulose sodium, silicon dioxide, aluminium hydroxide, ethanol, mixing, make granule, make various capsules under the Chinese Pharmacopoeia capsule item again, promptly.
Embodiment 3: the method for preparing this pharmaceutical preparation granule:
The first step: with preparation method 1-5
Second step: add an amount of adjuvant as starch, dextrin, sucrose, microcrystalline Cellulose, hyprolose, methylcellulose, ethyl cellulose, Carboxymethyl cellulose sodium, mixing is made granule, packing, promptly.
Embodiment 4: the method for preparing this pharmaceutical preparation pill:
The first step: with preparation method 1-5
Second step: add an amount of adjuvant as Mel, water, starch, dextrin, microcrystalline Cellulose, hyprolose, methylcellulose, ethyl cellulose, Carboxymethyl cellulose sodium, silicon dioxide, aluminium hydroxide, mixing, make honeyed pill, the watered pill, paste pill, concentrated pill, wax pill and the micropill of ball-type or class ball-type, packing, promptly.
Embodiment 5: the method for preparing this pharmaceutical preparation powder:
The first step: with preparation method 1-5
Second step: direct packaging or add an amount of adjuvant as starch, dextrin, sucrose, microcrystalline Cellulose, hyprolose, methylcellulose, ethyl cellulose, Carboxymethyl cellulose sodium, silicon dioxide, aluminium hydroxide, ethanol, mixing, packing, promptly.
Embodiment 6: the method for preparing this pharmaceutical preparation mixture
The first step: with preparation method 1-5
Second step: add an amount of adjuvant as sucrose, Mel, microcrystalline Cellulose, hyprolose, methylcellulose, ethyl cellulose, Carboxymethyl cellulose sodium, water, ethanol, antiseptic, mixing, packing, promptly.
Embodiment 7: the method for preparing this pharmaceutical preparation soft capsule:
The first step: with preparation method 1-5
Second step: adds an amount of adjuvant as: vegetable oil, glycerol, Cera Flava compacting or drip and make, packing, promptly.
Embodiment 8: the method for preparing this pharmaceutical preparation drop pill:
The first step: with preparation method 1-5
Second step: adds an amount of adjuvant as Polyethylene Glycol, hydrogenated vegetable oil, ethanol, mixing splashes in condensed fluid liquid paraffin or the dimethicone, and condensed fluid is removed in the contraction condensation, packing, promptly.
Embodiment 9: the method for preparing this pharmaceutical preparation unguentum:
The first step: with preparation method 1-5
Second step: add an amount of adjuvant as starch, dextrin, sucrose, Mel, cellulose, antiseptic, ethanol, mixing, packing, promptly.
Embodiment 10: the method for preparing this pharmaceutical preparation ointment:
The first step: with preparation method 1-5
Second step: add an amount of adjuvant as vaseline, liquid Paraffin, lanoline, Cera Flava, vegetable oil, animal oil, glyceryl monostearate, high fatty alcohol, Polyethylene Glycol, glycerinum amyli, glycerin gelatine, sodium carboxymethyl cellulose and emulsifying agent etc., mixing, packing, promptly.
Embodiment 11: the method for preparing this pharmaceutical preparation emplastrum:
The first step: with preparation method 1-5
Second the step: add an amount of adjuvant as: rubber cream common solvent is gasoline, normal hexane, and substrate commonly used has rubber, thermoplastic rubber, Colophonium, rosin derivative, vaseline, liquid Paraffin, lanoline, zinc oxide.Cataplasma substrate commonly used has sodium polyacrylate, Carboxymethyl cellulose sodium, gelatin, glycerol, micropowder silica gel.Patch substrate commonly used has ethylene-vinyl acetate copolymer, silicone rubber and Polyethylene Glycol.Emplastrum is commonly used cotton, non-woven cloth by lining material; Lid lining material commonly used has separate paper, plastic sheeting, aluminium foil-polyethylene to meet film, hard gauze.
Embodiment 12: the method for preparing this pharmaceutical preparation medicinal tea:
The first step: with preparation method 1-5
Second step: add an amount of adjuvant as Folium Camelliae sinensis, starch, dextrin, sucrose, Mel, cellulose, antiseptic, ethanol, mixing, packing, promptly.
Embodiment two
This Chinese medicine composition be the inventor according to Traditional Chinese medical theory, this Chinese medicine composition is that the inventor is according to nearly 40 years clinical experience, on the basis of secret prescription handed down in the family from generation to generation, in conjunction with the pharmaceutical preparation of modern production technology innovation and creation." heart and brain drop pill (or sheet or capsule) " by name observed through clinical use for many years, and determined curative effect is not seen obvious toxic and side effects.
Model case:
1. open good jade, man, 63 years old, people from Qingzhou, Shandong.In in such a month, and on such a day, 2000 first visit, pareordia is felt oppressed, the paroxysmal angina pectoris.The irregular outbreak moon is surplus.The precordial fullness pain appearred in readme before 3 years.At local hospital diagnosis is coronary heart disease.The buccal nitroglycerin can be alleviated during angina pectoris attacks.Local hospital electrocardiogram shows: ST-T section decline T ripple is low flat.Medication " heart and brain quieting drip pill ".Every day three times, each 10.Further consultation after 30 days.Readme is uncomfortable in chest than obviously improving in the past.And the number of times of angina pectoris attacks is than reducing in the past.And in inspections of having an electro-cardiogram of local hospital, show before the further consultation: the ST section descends and the T ripple hangs down to put down and all taken a turn for the better than in the past.Medication half a year is continued in the back, and original symptom occurs again, and mental status is good.
2. Li Ming, man, 52 years old, Shandong Zibo people, first visit in May, 2003.The patient is accidental uncomfortable in chest, cardiopalmus, unprocessed before 5 years, but spontaneous remission.April in this year, uncomfortable in chest, cardiopalmus took place frequently, and the companion breathes hard, weak.Diseases such as dizziness, insomnia.Point out in certain examination in hospital electrocardiogram: left anterior fascicular block.LAD-51 degree, examination of ocular fundus suggestion: arteriosclerosis secondary, cholesterol 6.5mmol/L, blood pressure: 14.7/8kp, the rhythm of the heart: 72 times/minute, rule is neat, A2＞P2, and hear sounds is normal, lung and liver spleen are no abnormal, conscious Mental fatigue, weak, the few tongue of dimly red tongue, pulse condition stringy and thready pulse.[dialectical] deficiency of both QI and YIN, stagnation of heart-blood, malaise.[method of treatment] benefiting QI and nourishing blood, blood circulation promoting and blood stasis dispelling, mind tranquilizing and the heart calming.Medication " heart and brain quieting drip pill ".Every day three times, each 10.Further consultation after 30 days: uncomfortable in chest after the readme medication, cardiopalmus can be controlled substantially.But tired back is easily sent out, and is still dizzy, insomnia, dreaminess.The tongue arteries and veins is the same.Continue medication, further consultation after 30 days.Spirit takes a turn for the better behind the readme medicine, and dizziness, insomnia, dreaminess improve.Continue medication.Incoming all announcement after 40 days, above-mentioned symptom disappears substantially.Can operate as normal.Now drug withdrawal several years just like ordinary person.
3. Haitao Liu, the man, 72 years old, Shandong Zibo people, in June, 2003 first visit was suffered from coronary heart disease, atrial fibrillation, heart failure 8 years, nervous asthma edema, walk 5 meters also need two people assist in.Successively, invalid with multiple Chinese medicine and western medicine at how tame hospital admission.Take " heart and brain quieting drip pill ".Every day three times, each 10.Further consultation after 30 days: obvious curative effects is arranged, treated 8 months, movable as ordinary person.
4. Wang Bo, the man, 52 years old, people from Shouguang, Shandong, first visit in November, 2004 because of nervous, saw a doctor in 8 years uncomfortable in chest, at how tame hospital admission, all be diagnosed as coronary heart disease, angina pectoris; Invalid all over the clothes Chinese medicine and western medicine, misery is felt embarrassed to mention.After the doctor of this place examination, think that diagnosis is wrong, take " heart and brain quieting drip pill ", every day three times, each 10.Further consultation after 10 days: obvious curative effects is arranged, treated 20 days, symptom all disappears.
5. Li Guang struggles against, man, 48 years old, people from lane, Shandong, in December, the 2004 first visit prescription on individual diagnosis of having a surplus nervous January uncomfortable in chest, medical college is diagnosed as myocarditis, sick sinus syndrome, because of the heart rate per minute has only 35 times, heart beating is too slow, loss of consciousness frequently occurs, the doctor advises installing pacemaker, and patient is because of hard up, then ask tcm diagnosis and treatment,, take " heart and brain quieting drip pill " through our treatment, every day three times, each 10.One week, heart rate returned to per minute 63 times, February and healing.
6. Zhao Li China, man, 54 years old, people from Qingdao, in December, 2004 increases the weight of March and examines because of cough, expectoration, asthma, chest pain 5 years, takes " heart and brain quieting drip pill ", every day three times, each 10, treat 5 days effectively in this punishment, 2 months transference cures are through controlling not recurrence again half a year.
7. Li Guangyao, the man, 48 years old, people from lane, Shandong, in December, 2004 first visit is made the coronary artery bracket art because of angina pectoris, and postoperative still has the intractable chest pain, and it is invalid to control for a long time.Take " heart and brain quieting drip pill ", every day three times, each 10, end January bitterly, and do not reaccess the half a year of taking medicine, and electrocardiogram also recovers normally, and cardiac hypertrophy disappears, and conduction block is also disappeared.
8. Zhao Jin justice man 69 years old Shandong people from lane, main suit: right side disorder of limb ' s activity, companion's dysphonia three months.Check: CT diagnosing of cerebral infarction: apoplexy (Qi deficiency blood stasis type) history of present illness: the patient was on March 12nd, 2003, and it is unfavorable not have obvious inducement right side limb activity, at that time the head fan, there are not vomiting and tic, companion's dysphonia, symptom increased the weight of gradually, went into the province the People's Hospital April 15, examine through CT and to be that the brain bolt forms, the right side limbs can not be swung at that time, were state of paralysis, once with thromboembolism preventing and thrombolytic drug therapy, the state of an illness slightly takes a turn for the better, take " heart and brain quieting drip pill ", every day three times, each 10, behind the two weeks, language forms a complete sentence mostly, but still can not express fully, and lower limb also slightly can be swung, toe joint is also movable, can be assisted to step one by family members, two steps.After taking medicine two months, but independent ambulation clinically is judged to be recovery from illness.
9. 65 years old cadre of so-and-so man of Zhao diagnosis: 1, cerebral thrombosis 2, oblongata back of the body outside syndrome 3, hypertension III phase patient have surplus the high disorders of blood history ten year, are in hospital in 19th in December, 2004 with " burst is dizzy, malfunctioning one day of right side limb activity ".The patient is dizzy, and order expands, hemiplegia, and slurred speech, drinking-water is choked and is coughed, singultus, the red tongue yellow fur, stringy and thready pulse, blood pressure 26/12RPa, cardiopulmonary (-), the liver spleen does not reach, and two lower limb have swollen.Neurologic check: the right side nasolabial fold shoals, right avertence lolls, left side horner's sign (+), left facial part and right side limbs intercrossing superficial sensory disturbance, right side limbs muscular strength II level, right side Babinski sign (+), blood, urine, just conventional normal, blood glucose, liver function, kidney merit are no abnormal, triglyceride 0.9mmol/L, cholesterol 5.0mmol/L, brain CT shows: left basal ganglia region and top cerebral infarction.Take " heart and brain quieting drip pill ", every day three times, each 10, after ten days, dizzy disease closing alleviates, blood pressure 22/12RPa, and the singultus transference cure is after one course of treatment of medication, Myodynamia recovery can be walked down to the IV level, check triglyceride 0.78mmol/L, cholesterol 4.8mmol/L.
10. surplus 47 years old cerebral hemorrhage patient hypertension ten of Jia Fang woman year, in 2002 because of obnubilation, the burst cerebral hemorrhage was in hospital April 16 and is rescued the back patient and lose serious limbs disturbance, right side limbs panplegia are arranged.Take " heart and brain quieting drip pill ", every day three times, each 10, patient's upper and lower extremities body can activity be stretched in the wrongly after 27 days, continues again to take 2 months, and patient's limb function improves day by day, can walk on their own, and has reached the recurrence of after treatment and prevention of brain angiopathy.
Claims (10)
1, a kind of effect that has supporting vital QI to relieve the primary cause of disease, blood circulation promoting and blood stasis dispelling, eliminates phlegm for resuscitation, be used for the Chinese medicine composition of obstruction of qi in the chest and cardialgia, uncomfortable in chest, chest pain, shortness of breath and palpitation, coronary heart disease, angina pectoris, myocardial infarction, apoplectic coma, cerebral hemorrhage, cerebral thrombosis brain, apoplectic hemiplegia, coma, obnubilation, encephalitis, toxic encephalopthy, heating, wherein the recipe ratio 1 of each raw material is:
Calculus Bovis 2-10 part Borneolum Syntheticum 20-60 part Radix Notoginseng 0-80 part Radix Ginseng 0-80 part.
Calculus Bovis in the prescription comprises natural Calculus Bovis and artificial Calculus Bovis, Calculus Bovis cultivating, In vitro cultured Calculus Bovis; Radix Ginseng comprises Radix Ginseng, wild ginseng, Park Ginseng, Korean Ginseng and Radix Panacis Quinquefolii.
2, Chinese medicine composition according to claim 1, wherein the recipe ratio 2 of each raw material is:
Calculus Bovis 8-10 part Borneolum Syntheticum 20-40 part Radix Notoginseng 10-80 part Radix Ginseng 10-80 part.
3, Chinese medicine composition according to claim 1, wherein the recipe ratio 3 of raw material is:
Calculus Bovis 8-10 part Borneolum Syntheticum 20-40 part Radix Notoginseng 10-80 part.
4, Chinese medicine composition according to claim 1, wherein the recipe ratio 4 of raw material is:
Calculus Bovis 8-10 part Borneolum Syntheticum 20-40 part Radix Ginseng 10-80 part.
5; pharmaceutical preparation according to claim 1 and 2; the preparation method that it is characterized in that said pharmaceutical preparation is: above four Chinese medicine material; Radix Ginseng; Radix Notoginseng powder is broken into coarse powder; with 60%～95% alcohol reflux secondary, each 0.5～3 hour, extract fully; merge extractive liquid; filter, filtrate recycling ethanol, and continue to be concentrated into the clear paste of relative density 1.20～1.25 (60 ℃ of surveys); mix a small amount of kieselguhr; (80 ℃) drying under reduced pressure, and be ground into fine powder, with fine powder alcohol reflux secondary; each 1 hour; put cold back and filter, filtrate recycling ethanol also continues to be concentrated into the clear paste of relative density 1.20～1.35 (60 ℃ of surveys), with all the other Calculus Boviss; the Borneolum Syntheticum mixing; all be ground into impalpable powder; according to the Chinese medicine preparation general rule, make various form of Chinese drug, promptly.
6, pharmaceutical preparation according to claim 1 and 2; the preparation method that it is characterized in that said pharmaceutical preparation is: above four Chinese medicine material; Radix Ginseng, Radix Notoginseng powder are broken into coarse powder; with 60%～95% alcohol reflux secondary; each 0.5～3 hour; extract fully; merge extractive liquid; filter, filtrate recycling ethanol, and continue to be concentrated into clear paste that relative density is 1.20～1.35 (60 ℃ of surveys) and Calculus Bovis, Borneolum Syntheticum mixing; all be ground into impalpable powder; according to the Chinese medicine preparation general rule, make various form of Chinese drug, promptly.
7, according to claim 3 or 4 described pharmaceutical preparatioies, it is characterized in that the preparation method of said pharmaceutical preparation is: above three flavor medical materials, Radix Ginseng or Radix Notoginseng powder are broken into coarse powder; with 60%～95% ethanol percolate extraction, extract fully merge extractive liquid; filter; filtrate recycling ethanol, and continue to be concentrated into the clear paste of relative density 1.20～1.35 (60 ℃ of surveys), with all the other Calculus Boviss, Borneolum Syntheticum mixing; all be ground into impalpable powder; according to the Chinese medicine preparation general rule, make various form of Chinese drug, promptly.
8; according to claim 3 or 4 described pharmaceutical preparatioies; the preparation method that it is characterized in that said pharmaceutical preparation is: above three flavor medical materials; Radix Ginseng or Radix Notoginseng powder are broken into coarse powder; with 60%～95% alcohol reflux secondary, each 0.5～3 hour, extract fully; merge extractive liquid; filter, filtrate recycling ethanol, and continue to be concentrated into the clear paste of relative density 1.20～1.25 (60 ℃ of surveys); mix a small amount of kieselguhr; (80 ℃) drying under reduced pressure, and be ground into fine powder, with fine powder alcohol reflux secondary; each 1 hour; put cold back and filter, filtrate recycling ethanol also continues to be concentrated into the clear paste of relative density 1.20～1.35 (60 ℃ of surveys), with all the other Calculus Boviss; the Borneolum Syntheticum mixing; all be ground into impalpable powder; according to the Chinese medicine preparation general rule, make various form of Chinese drug, promptly.
9; according to claim 3 or 4 described pharmaceutical preparatioies; the preparation method that it is characterized in that said pharmaceutical preparation is: above three flavor medical materials; Radix Ginseng or Radix Notoginseng powder are broken into coarse powder; with 60%～95% alcohol reflux secondary, each 0.5～3 hour, extract fully; merge extractive liquid; filter, filtrate recycling ethanol, and continue to be concentrated into the clear paste of relative density 1.20～1.25 (60 ℃ of surveys); mix a small amount of kieselguhr; (80 ℃) drying under reduced pressure, and be ground into fine powder, with fine powder and Calculus Bovis alcohol reflux secondary; each 1 hour; put cold back and filter, filtrate recycling ethanol also continues to be concentrated into the clear paste of relative density 1.20～1.35 (60 ℃ of surveys), with the Borneolum Syntheticum mixing; all be ground into impalpable powder; according to the Chinese medicine preparation general rule, make various form of Chinese drug, promptly.
10, according to claim 3 or 4 described pharmaceutical preparatioies, it is characterized in that the preparation method of said pharmaceutical preparation is: above three flavor medical materials, Radix Ginseng or Radix Notoginseng powder are broken into fine powder; Calculus Bovis, Borneolum Syntheticum are ground into fine powder and Radix Ginseng or Radix Notoginseng fine powder mixing respectively separately, according to the Chinese medicine preparation general rule, make various form of Chinese drug, promptly.
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| CN101698090B (en) * | 2009-11-19 | 2011-03-16 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composite for treating coma and heart syncope symptoms and preparation method thereof |
| CN104056188A (en) * | 2014-06-01 | 2014-09-24 | 程寿瑶 | Spirit-recovering and orifice-clearing powder for treating apoplexia |
| CN105687798A (en) * | 2016-03-22 | 2016-06-22 | 山东明人福瑞达卫生材料有限公司 | External traditional Chinese medicinal preparation for treating stroke and preparation method of external traditional Chinese medicinal preparation |
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2006
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101698090B (en) * | 2009-11-19 | 2011-03-16 | 泰一和浦（北京）中医药研究院有限公司 | Traditional Chinese medicine composite for treating coma and heart syncope symptoms and preparation method thereof |
| CN104056188A (en) * | 2014-06-01 | 2014-09-24 | 程寿瑶 | Spirit-recovering and orifice-clearing powder for treating apoplexia |
| CN104056188B (en) * | 2014-06-01 | 2017-05-24 | 程寿瑶 | Spirit-recovering and orifice-clearing powder for treating apoplexia |
| CN105687798A (en) * | 2016-03-22 | 2016-06-22 | 山东明人福瑞达卫生材料有限公司 | External traditional Chinese medicinal preparation for treating stroke and preparation method of external traditional Chinese medicinal preparation |
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