CN108353946A - A kind of Agrimycin and preparation method thereof - Google Patents
A kind of Agrimycin and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Agrimycins and preparation method thereof, belong to plant sterilization pharmaceutical arts.The present invention is compounded with active components A and B, is acted synergistically well using streptomycin sulphate as active compound, its germicidal efficiency is made to improve, and fungicidal spectrum expands, and simultaneous can control fungal disease, and pathogen is difficult to develop immunity to drugs；First, some of nano-Ag particles and bacterium surface protein molecules carry out particular combination, change phospholipid bilayer structure, permeability of cell membrane is caused to increase, even cause the rupture of cell membrane, the fungistatic effect of contained terpenoid in active constituent B, Hui Fa You ﹑ flavone compounds etc. can be significantly improved, and then leads to bacterial death.The present invention solves that current fungicide bactericidal effect site is single, and germ is easy to generate medicament the variation of adaptability, causes effect of chemical control to decline even invalid, while prevent bacterial disease, cannot at the same simultaneous the problem of controlling fungal disease.
Description
Technical field
The invention belongs to plant sterilization pharmaceutical arts, and in particular to a kind of Agrimycin and preparation method thereof.
Background technology
Agrimycin belongs to one of the product of plant sterilization medicament class.Streptomysin is a kind of aminoglycoside antibiosis
Element.Its mechanism of action is the ribosomes acted in bacterial body, inhibits bacterio protein synthesis, and destroy the complete of bacterial cell membrane
Whole property.There is sensitive bacteria oxygen dependence antibiotic transmembrane transport system, streptomysin can pass through epicyte through Passive diffusion first
Then porin enters the Asias ribosomes 30S for not being reversibly bound to separation into the cell through this movement system by cell membrane
On base, lead to A destructions, and then aminoacyl tRNA is prevented to be properly positioned at A, the ribosomal assembling of interference function presses down
The compound formation of 70S initiatings processed；TRNA and mRNA coding triplet erroneous matchings are induced, complete ribosomal 30S subunits are caused
Genetic code is mispronounced, abnormal, non-functional protein is caused to synthesize；Termination factor and A combinations are hindered, the peptide synthesized is made
Chain cannot discharge, and prevent the complete ribosomes dissociation of 70S.
Streptomysin is microbial source bactericide, can effectively prevent phytobacterial disease, such as apple, fire blight of pear, cigarette
Careless wildfire, blue mildew, soft rot of cabbage, tomato bacterial mottled rot disease, late blight, seed potato rot disease, balck shank, Huang
Melon angular leaf spot, downy mildew, Kidney bean downy mildew, bacterial epidemic disease, celery bacterial epidemic disease, sesame bacterial leaf spot.Sulfate chain
Mycin is antibiotics fungicide, mainly passes through the synthesis for interfering bacterio protein and messenger ribonucleic acid and 30S ribosomes
Subunit in conjunction with and inhibit the extension of peptide chain, Gram-negative bacteria and positive bacteria etc. are all had a strong inhibitory effect, to a variety of
The bacterial disease of crop has preventive and therapeutic effect, also there is certain preventive and therapeutic effect to some fungal diseases.Agricultural streptomycin sulphate is
It is a kind of efficiently, it is low toxicity, low-residual, nuisanceless, the antibiotics pesticide being compatible with the environment has both therapeutic and protective effects, is one
Kind absorbability and environment-friendly type fungicide.Have many advantages, such as that has a broad antifungal spectrum, selectivity is strong, is easy to be absorbed by crops, especially to bacterium
Venereal disease evil has special efficacy.
Currently, there are many commercially available bactericide type, but it is single still to there is bactericidal effect site in actual use,
Germ is easy to generate medicament the variation of adaptability, causes effect of chemical control to decline even invalid, in prevention bacterial disease
While, cannot simultaneously simultaneous the problem of controlling fungal disease.
Invention content
The technical problems to be solved by the invention：Single for current fungicide bactericidal effect site, germ is easy to medicine
Agent generates the variation of adaptability, causes effect of chemical control to decline even invalid, while preventing bacterial disease, Bu Nengtong
When simultaneous the problem of controlling fungal disease, a kind of preparation method of Agrimycin is provided.
In order to solve the above technical problems, the present invention is using technical solution as described below：
A kind of Agrimycin, according to the mass fraction, including following component, 5 ~ 10 portions of streptomycin sulphates, 4 ~ 8 parts of dispersants, 3
~ 5 parts of thickeners, 3 ~ 5 stabilizers, 4 ~ 8 portions of disintegrants, 3 ~ 5 parts of antifoaming agent, which is characterized in that 12 ~ 18 parts of active component As, 10 ~
15 parts of active component B；
The preparation of active component A：
S1：According to the mass fraction, 20 ~ 25 parts of silver nitrate solutions are taken, 7 ~ 12 parts of sodium hydroxide solutions are added, react 30 ~ 40min,
Centrifuge washing obtains Ag2O solids add 10 ~ 15 parts of ammonium hydroxide, are mixed, Ag2O is completely dissolved to get silver ammino solution；
S2：According to the mass fraction, 6 ~ 10 parts of silver ammino solutions and 6 ~ 12 polyvinylpyrrolidonesolution solutions are taken, are shaken up, 3 ~ 8 parts of lemons are added
Lemon three sodium solutions of acid, are mixed, obtain colourless transparent solution, shake, by 20 ~ 25min of 200W mercury lamp illumination to get activity
Ingredient A；
The preparation of active component B：According to the mass fraction, 10 ~ 15 parts of waxgourd peels, 8 ~ 13 portions of cordate houttuynias, 12 ~ 18 portions of aloes are taken, are washed
Only, sieving is dry, pulverize, sieving particle is taken, is extracted with 30 ~ 45 parts of ethyl alcohol, in 60 ~ 70 DEG C, 1.5 ~ 2 h is extracted, takes supernatant
Liquid, vacuum filtration, 40 ~ 50 DEG C of rotary evaporations are to get active component B.
The dispersant be microcrystalline wax and butyl stearate, in mass ratio 2:1 mixing is to get dispersant.
The thickener is any one of sodium carboxymethylcellulose, sodium alginate, polyurethane, polyethylene glycol oxide or more
Kind.
The stabilizer be epoxidized soybean oil, triphenyl phosphite, ricinoleic acid, any one of epoxychloropropane or
It is a variety of.
The disintegrant be sodium carboxymethyl starch and crosslinked polyvinylpyrrolidone, in mass ratio 1:1 ~ 2 mixes to get collapsing
Solve agent.
The antifoaming agent is any one of dimethyl silicone polymer, polymerization propylene oxide, ethylene oxide, propylene oxide
Or it is a variety of.
The preparation method includes the following steps：
（1）According to the mass fraction, take 10 portions of streptomycin sulphates, 4 ~ 8 parts of dispersants, 3 ~ 5 parts of thickeners, 3 ~ 5 stabilizers, 4 ~ 8 parts
Disintegrant, 3 ~ 5 parts of Xiao Pao Ji ﹑, 5 ~ 10 parts of 13 ~ 18 parts of active component B ﹑ of Liu acid Lian Mei Su 12 ~ 18 parts of ﹑, 10 ~ 15 parts of active component A ﹑
Water；
（2）In 35 ~ 40 DEG C, take dispersant, thickener, stabilizer, disintegrant, antifoaming agent, water that 25 ~ 30min is mixed, it is rear to drop
For temperature to 20 ~ 25 DEG C, static 25 ~ 30min obtains auxiliary material base-material；
（2）Auxiliary material base-material is taken, Liu acid Lian Mei Su ﹑ active component A ﹑ active component B are added, is mixed, extruder grain, drying,
Sieving is to get Agrimycin.
Compared with other methods, advantageous effects are the present invention：
The present invention compounds with active components A and B using streptomycin sulphate as active compound, acts synergistically well, its germicidal efficiency is made to carry
Height, fungicidal spectrum expand, and simultaneous can control fungal disease, and pathogen is difficult to develop immunity to drugs；
First, some of nano-Ag particles and bacterium surface protein molecules carry out particular combination, phospholipid bilayer knot is changed
Structure causes permeability of cell membrane to increase, or even causes the rupture of cell membrane, can significantly improve contained terpene in active constituent B
The fungistatic effect of compound, Hui Fa You ﹑ flavone compounds etc., and then lead to bacterial death, second is that nano silver and aloe extraction
Ingredient can damage the inhereditary material of bacterium with DNA association reactions, be allowed to be replicated, and then kill bacterium；Third, receiving
Rice silver particles surface constantly releases positively charged silver ion, and silver ion is acted on by the way that there is a natural attraction between the sexes, direct with bacterial cell membrane
Haptoreaction, to play antibacterial action；Active component B is the compounding of several plant extracting solution, is provided to active component A good
Good chemical environment, gives full play to its effect, expands the action site of sterilization, and will not develop immunity to drugs, to fungal disease
Also there is inhibiting effect.
Specific implementation mode
Streptomycin sulphate：It is purchased from the chemical Science and Technology Ltd. of Hubei Wade profit.
Active component A：Nano silver colloidal sol.
Active component B：Waxgourd peel, cordate houttuynia, aloe compound ethanol extract.
Dispersant be microcrystalline wax and butyl stearate, in mass ratio 2:1 mixing is to get dispersant.
Thickener is any one or more of sodium carboxymethylcellulose, sodium alginate, polyurethane, polyethylene glycol oxide.
Stabilizer is any one of epoxidized soybean oil, triphenyl phosphite, ricinoleic acid, epoxychloropropane or more
Kind.
Disintegrant be sodium carboxymethyl starch and crosslinked polyvinylpyrrolidone, in mass ratio 1:1 ~ 2 mixing, up to being disintegrated
Agent.
Antifoaming agent is any one of dimethyl silicone polymer, polymerization propylene oxide, ethylene oxide, propylene oxide or more
Kind.
The preparation of active component A：
S1：According to the mass fraction, the silver nitrate solution for taking 20 ~ 25 parts of a concentration of 0.1mol/L, be slowly added to 7 ~ 12 parts it is a concentration of
The sodium hydroxide solution of 0.1mol/L, reacts 30 ~ 40min, and centrifuge washing obtains Ag2O solids add 10 ~ 15 parts of ammonium hydroxide,
It is mixed, makes Ag2O is completely dissolved to get silver ammino solution；
S2：According to the mass fraction, the polyvinylpyrrolidonesolution solution of 6 ~ 10 parts of silver ammino solutions and 6 ~ 12 a concentration of 0.4mol/L is taken
It in quartz test tube, shakes up, 3 ~ 8 parts of 0.02mol/L citric acid three sodium solutions is added, be mixed, obtain colourless transparent solution,
Reaction solution is passed through into 20 ~ 25min of 200W mercury lamp illumination to get active component A with the rotating speed rotation of 50 ~ 60 r/min.
The preparation of active component B：According to the mass fraction, 10 ~ 15 parts of waxgourd peels, 8 ~ 13 portions of cordate houttuynias, 12 ~ 18 portions of reeds are taken
Luxuriant growth is cleaned, is dried, vacuum microwave drying, be crushed 150 mesh sieve, is taken sieving particle, is 95% with 30 ~ 45 parts of volume fractions
Ethyl alcohol extracts, and in 60 ~ 70 DEG C, extracts 1.5 ~ 2 h, takes supernatant, is filtered by vacuum, 40 ~ 50 DEG C of rotary evaporations are to get activearm
Divide B.
A kind of preparation method of Agrimycin includes the following steps：
（1）According to the mass fraction, take 10 portions of streptomycin sulphates, 4 ~ 8 parts of dispersants, 3 ~ 5 parts of thickeners, 3 ~ 5 stabilizers, 4 ~ 8 parts
Disintegrant, 3 ~ 5 parts of Xiao Pao Ji ﹑, 5 ~ 10 parts of 13 ~ 18 parts of active component B ﹑ of Liu acid Lian Mei Su 12 ~ 18 parts of ﹑, 10 ~ 15 parts of active component A ﹑
Water；
（2）In 35 ~ 40 DEG C, take dispersant, thickener, stabilizer, disintegrant, antifoaming agent, water that 25 ~ 30min is mixed, it is rear to drop
For temperature to 20 ~ 25 DEG C, static 25 ~ 30min obtains auxiliary material base-material；
（2）Auxiliary material base-material is taken, Liu acid Lian Mei Su ﹑ active component A ﹑ active component B are added, is mixed, extruder grain, vacuum is dry
It is dry, 200 mesh sieve is crossed to get Agrimycin.
Streptomycin sulphate：It is purchased from the chemical Science and Technology Ltd. of Hubei Wade profit.
Active component A：Nano silver colloidal sol.
Active component B：Waxgourd peel, cordate houttuynia, aloe compound ethanol extract.
Dispersant be microcrystalline wax and butyl stearate, in mass ratio 2:1 mixing is to get dispersant.
Thickener is any one or more of sodium carboxymethylcellulose, sodium alginate, polyurethane, polyethylene glycol oxide.
Stabilizer is any one of epoxidized soybean oil, triphenyl phosphite, ricinoleic acid, epoxychloropropane or more
Kind.
Disintegrant be sodium carboxymethyl starch and crosslinked polyvinylpyrrolidone, in mass ratio 1:1 mixing, up to disintegrant.
Antifoaming agent is any one of dimethyl silicone polymer, polymerization propylene oxide, ethylene oxide, propylene oxide or more
Kind.
The preparation of active component A：
S1：According to the mass fraction, the silver nitrate solution for taking 20 parts of a concentration of 0.1mol/L is slowly added to 7 parts of a concentration of 0.1mol/
The sodium hydroxide solution of L, reacts 30min, and centrifuge washing obtains Ag2O solids add 10 parts of ammonium hydroxide, are mixed, make Ag2O
It is completely dissolved to get silver ammino solution；
S2：According to the mass fraction, take the polyvinylpyrrolidonesolution solution of 6 parts of silver ammino solutions and 6 a concentration of 0.4mol/L in quartz
It in test tube, shakes up, 3 parts of 0.02mol/L citric acid three sodium solutions is added, be mixed, obtain colourless transparent solution, will react molten
Liquid is with the rotating speed rotation of 50 r/min by 200W mercury lamp illumination 20min to get active component A.
The preparation of active component B：According to the mass fraction, 10 parts of waxgourd peels, 8 portions of cordate houttuynias, 12 portions of aloes are taken, are cleaned, are shone
Dry, vacuum microwave drying crushed 150 mesh sieve, take sieving particle, and the ethyl alcohol for being 95% with 30 parts of volume fractions extracts, in 60
DEG C, 1.5 h are extracted, supernatant is taken, are filtered by vacuum, 40 DEG C of rotary evaporations are to get active component B.
A kind of preparation method of Agrimycin includes the following steps：
（1）According to the mass fraction, 10 portions of streptomycin sulphates, 4 parts of dispersants, 3 parts of thickeners, 3 stabilizers, 4 parts of disintegrants, 3 are taken
Part Xiao Pao Ji 5 parts of Liu acid Lian Mei Su 12 parts of ﹑, 10 parts of active component A ﹑, 13 parts of water of active component B ﹑ of ﹑；
（2）In 35 DEG C, take dispersant, thickener, stabilizer, disintegrant, antifoaming agent, water be mixed 25min, after be cooled to 20
DEG C, static 25min obtains auxiliary material base-material；
（3）Auxiliary material base-material is taken, Liu acid Lian Mei Su ﹑ active component A ﹑ active component B are added, is mixed, extruder grain, vacuum is dry
It is dry, 200 mesh sieve is crossed to get Agrimycin.
Streptomycin sulphate：It is purchased from the chemical Science and Technology Ltd. of Hubei Wade profit.
Active component A：Nano silver colloidal sol.
Active component B：Waxgourd peel, cordate houttuynia, aloe compound ethanol extract.
Dispersant be microcrystalline wax and butyl stearate, in mass ratio 2:1 mixing is to get dispersant.
Thickener is any one or more of sodium carboxymethylcellulose, sodium alginate, polyurethane, polyethylene glycol oxide.
Stabilizer is any one of epoxidized soybean oil, triphenyl phosphite, ricinoleic acid, epoxychloropropane or more
Kind.
Disintegrant be sodium carboxymethyl starch and crosslinked polyvinylpyrrolidone, in mass ratio 1:2 mixing, up to disintegrant.
Antifoaming agent is any one of dimethyl silicone polymer, polymerization propylene oxide, ethylene oxide, propylene oxide or more
Kind.
The preparation of active component A：
S1：According to the mass fraction, the silver nitrate solution for taking 25 parts of a concentration of 0.1mol/L, be slowly added to 12 parts it is a concentration of
The sodium hydroxide solution of 0.1mol/L, reacts 40min, and centrifuge washing obtains Ag2O solids, add 15 parts of ammonium hydroxide, and mixing is stirred
It mixes, makes Ag2O is completely dissolved to get silver ammino solution；
S2：According to the mass fraction, take the polyvinylpyrrolidonesolution solution of 10 parts of silver ammino solutions and 12 a concentration of 0.4mol/L in stone
It in English test tube, shakes up, 8 parts of 0.02mol/L citric acid three sodium solutions is added, be mixed, obtain colourless transparent solution, will react
Solution is with the rotating speed rotation of 60 r/min by 200W mercury lamp illumination 25min to get active component A.
The preparation of active component B：According to the mass fraction, 15 parts of waxgourd peels, 13 portions of cordate houttuynias, 18 portions of aloes are taken, are cleaned, are shone
Dry, vacuum microwave drying crushed 150 mesh sieve, take sieving particle, and the ethyl alcohol for being 95% with 45 parts of volume fractions extracts, in 70
DEG C, 2 h are extracted, supernatant is taken, are filtered by vacuum, 50 DEG C of rotary evaporations are to get active component B.
A kind of preparation method of Agrimycin includes the following steps：
（1）According to the mass fraction, 10 portions of streptomycin sulphates, 8 parts of dispersants, 5 parts of thickeners, 5 stabilizers, 8 parts of disintegrants, 5 are taken
Part Xiao Pao Ji 10 parts of Liu acid Lian Mei Su 18 parts of ﹑, 15 parts of active component A ﹑, 18 parts of water of active component B ﹑ of ﹑；
（2）In 40 DEG C, take dispersant, thickener, stabilizer, disintegrant, antifoaming agent, water be mixed 30min, after be cooled to 25
DEG C, static 30min obtains auxiliary material base-material；
（3）Auxiliary material base-material is taken, Liu acid Lian Mei Su ﹑ active component A ﹑ active component B are added, is mixed, extruder grain, vacuum is dry
It is dry, 200 mesh sieve is crossed to get Agrimycin.
Streptomycin sulphate：It is purchased from the chemical Science and Technology Ltd. of Hubei Wade profit.
Active component A：Nano silver colloidal sol.
Active component B：Waxgourd peel, cordate houttuynia, aloe compound ethanol extract.
Dispersant be microcrystalline wax and butyl stearate, in mass ratio 2:1 mixing is to get dispersant.
Thickener is any one or more of sodium carboxymethylcellulose, sodium alginate, polyurethane, polyethylene glycol oxide.
Stabilizer is any one of epoxidized soybean oil, triphenyl phosphite, ricinoleic acid, epoxychloropropane or more
Kind.
Disintegrant be sodium carboxymethyl starch and crosslinked polyvinylpyrrolidone, in mass ratio 1:1.5 mixing, up to being disintegrated
Agent.
Antifoaming agent is any one of dimethyl silicone polymer, polymerization propylene oxide, ethylene oxide, propylene oxide or more
Kind.
The preparation of active component A：
S1：According to the mass fraction, the silver nitrate solution for taking 22.5 parts of a concentration of 0.1mol/L, be slowly added to 9.5 parts it is a concentration of
The sodium hydroxide solution of 0.1mol/L, reacts 35min, and centrifuge washing obtains Ag2O solids add 12.5 parts of ammonium hydroxide, mixing
Stirring, makes Ag2O is completely dissolved to get silver ammino solution；
S2：According to the mass fraction, take the polyvinylpyrrolidonesolution solution of 8 parts of silver ammino solutions and 9 a concentration of 0.4mol/L in quartz
It in test tube, shakes up, 5.5 parts of 0.02mol/L citric acid three sodium solutions is added, be mixed, obtain colourless transparent solution, will react
Solution is with the rotating speed rotation of 55 r/min by 200W mercury lamp illumination 22.5min to get active component A.
The preparation of active component B：According to the mass fraction, 12.5 parts of waxgourd peels, 10.5 portions of cordate houttuynias, 15 portions of aloes are taken, are washed
Only, it dries, vacuum microwave drying, crushed 150 mesh sieve, take sieving particle, the ethyl alcohol for being 95% with 37.5 parts of volume fractions carries
It takes, in 65 DEG C, extracts 1.75 h, take supernatant, be filtered by vacuum, 45 DEG C of rotary evaporations are to get active component B.
A kind of preparation method of Agrimycin includes the following steps：
（1）According to the mass fraction, 10 portions of streptomycin sulphates, 6 parts of dispersants, 4 parts of thickeners, 4 stabilizers, 6 parts of disintegrants, 4 are taken
Part Xiao Pao Ji 7.5 parts of Liu acid Lian Mei Su 15 parts of ﹑, 12.5 parts of active component A ﹑, 15.5 parts of water of active component B ﹑ of ﹑；
（2）In 37.5 DEG C, take dispersant, thickener, stabilizer, disintegrant, antifoaming agent, water that 27.5min is mixed, it is rear to cool down
To 22.5 DEG C, static 27.5min obtains auxiliary material base-material；
（3）Auxiliary material base-material is taken, Liu acid Lian Mei Su ﹑ active component A ﹑ active component B are added, is mixed, extruder grain, vacuum is dry
It is dry, 200 mesh sieve is crossed to get Agrimycin.
Comparative example 1 and the preparation method of embodiment 2 are essentially identical, have only the difference is that lacking active component A.
Comparative example 2 and the preparation method of embodiment 2 are essentially identical, have only the difference is that lacking active component A and activearm
Divide B.
Comparative example 3：The fungicide of company of Wenzhou City production
Field experiment：Using the Agrimycin prepared by embodiment 1 ~ 3 and the fungicide prepared by comparative example as examination
Group is tested, it is experiment field to divide 20 mu of corn, 30 mu of wheat, 5 mu of watermelon, 7 parts is divided into, wherein 6 parts are carried out by Isodose
Spray prevention, continuous three do not wither every year, it is yellow wither, the destruction to crop such as virus, the jade average per acre that do not applied with crop field
18% or more rice volume increase, 9% or more wheat, 20% or more watermelon；
Tomato growth stage virus efficiency test：Divide tomato species growing area, 2 × 6m of plot area2.By the streptomysin of the 30g present invention
Fungicide is watered 30kg dilutions respectively with the fungicide prepared by comparative example.It sprays for the first time, after a week second of sprinkling, interval
Last time sprays after a week, investigates the state of an illness, preventive effect result average value such as the following table 1 of experiment in three weeks after a week：
Table 1
| Sample | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 1 | Comparative example 2 | Comparative example 3 |
| Preventive effect | 94% | 98% | 95% | 90%~92% | 85%~88% | 77%~80% |
Wheat powdery mildew, banded sclerotial blight, rust efficiency test：With prepared by the embodiment of the present invention 1 ~ 3 Agrimycin and comparison
Fungicide prepared by example is respectively as test group, and 30g, is watered 30kg and is sprayed in the wheat growth middle and later periods per acre.Divide wheat
Growing area, 3 × 5m of plot area2, spray for the first time, 20 days investigation state of an illness after spray, 5 points of samplings, record line by 200 plants every
Blight, powdery mildew, the state of an illness of rust.In triplicate, it participates in the experiment medicament.Preventive effect result average value such as the following table 2 of experiment：
Table 2
| Sample | Embodiment 1 | Embodiment 2 | Embodiment 3 | Comparative example 1 | Comparative example 2 | Comparative example 3 |
| Banded sclerotial blight preventive effect % | 85% | 89% | 87% | 81%~83% | 77%~79% | 72%~75% |
| Powdery mildew preventive effect % | 86% | 88% | 87% | 81%~82% | 78%~80% | 70%~73% |
| Rust preventive effect % | 83% | 87% | 85% | 80%~82% | 75%~79% | 68%~71% |
The Agrimycin bactericidal effect site of the present invention is multi-faceted, and germ is not easy to generate medicament the variation of adaptability,
Control effect is good, while preventing bacterial disease, can simultaneously simultaneous the problem of controlling fungal disease.In conclusion this hair
Prepared Agrimycin application effect complies fully with requirement in bright, is worth promoting and uses.
Claims (7)
1. a kind of Agrimycin, according to the mass fraction, including following component, 5 ~ 10 portions of streptomycin sulphates, 4 ~ 8 parts of dispersions
Agent, 3 ~ 5 parts of thickeners, 3 ~ 5 stabilizers, 4 ~ 8 portions of disintegrants, 3 ~ 5 parts of antifoaming agent, which is characterized in that 12 ~ 18 parts of active component As,
10 ~ 15 parts of active component B；
The preparation of active component A：
S1：According to the mass fraction, 20 ~ 25 parts of silver nitrate solutions are taken, 7 ~ 12 parts of sodium hydroxide solutions are added, react 30 ~ 40min,
Centrifuge washing obtains Ag2O solids add 10 ~ 15 parts of ammonium hydroxide, are mixed, Ag2O is completely dissolved to get silver ammino solution；
S2：According to the mass fraction, 6 ~ 10 parts of silver ammino solutions and 6 ~ 12 polyvinylpyrrolidonesolution solutions are taken, are shaken up, 3 ~ 8 parts of lemons are added
Lemon three sodium solutions of acid, are mixed, obtain colourless transparent solution, shake, by 20 ~ 25min of 200W mercury lamp illumination to get activity
Ingredient A；
The preparation of active component B：According to the mass fraction, 10 ~ 15 parts of waxgourd peels, 8 ~ 13 portions of cordate houttuynias, 12 ~ 18 portions of aloes are taken, are washed
Only, sieving is dry, pulverize, sieving particle is taken, is extracted with 30 ~ 45 parts of ethyl alcohol, in 60 ~ 70 DEG C, 1.5 ~ 2 h is extracted, takes supernatant
Liquid, vacuum filtration, 40 ~ 50 DEG C of rotary evaporations are to get active component B.
2. Agrimycin according to claim 1, which is characterized in that the dispersant is microcrystalline wax and stearic acid fourth
Ester, in mass ratio 2:1 mixing is to get dispersant.
3. Agrimycin according to claim 1, which is characterized in that the thickener is sodium carboxymethylcellulose, sea
Any one or more of mosanom, polyurethane, polyethylene glycol oxide.
4. Agrimycin according to claim 1, which is characterized in that the stabilizer is epoxidized soybean oil, phosphorous acid
Any one or more of triphenylmethyl methacrylate, ricinoleic acid, epoxychloropropane.
5. Agrimycin according to claim 1, which is characterized in that the disintegrant is sodium carboxymethyl starch and crosslinking
Polyvinylpyrrolidone, in mass ratio 1:1 ~ 2 mixing is to get disintegrant.
6. Agrimycin according to claim 1, which is characterized in that the antifoaming agent is dimethyl silicone polymer, gathers
Any one or more of cyclization Ethylene Oxide, ethylene oxide, propylene oxide.
7. a kind of preparation method of the Agrimycin as described in claim 1 ~ 3 any one, which is characterized in that the preparation side
Method includes the following steps：
（1）According to the mass fraction, take 10 portions of streptomycin sulphates, 4 ~ 8 parts of dispersants, 3 ~ 5 parts of thickeners, 3 ~ 5 stabilizers, 4 ~ 8 parts
Disintegrant, 3 ~ 5 parts of Xiao Pao Ji ﹑, 5 ~ 10 parts of 13 ~ 18 parts of active component B ﹑ of Liu acid Lian Mei Su 12 ~ 18 parts of ﹑, 10 ~ 15 parts of active component A ﹑
Water；
（2）In 35 ~ 40 DEG C, take dispersant, thickener, stabilizer, disintegrant, antifoaming agent, water that 25 ~ 30min is mixed, it is rear to drop
For temperature to 20 ~ 25 DEG C, static 25 ~ 30min obtains auxiliary material base-material；
（3）Auxiliary material base-material is taken, Liu acid Lian Mei Su ﹑ active component A ﹑ active component B are added, is mixed, extruder grain, drying,
Sieving is to get Agrimycin.
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