CN103960232A - Abamectin slow-release granula and preparation method thereof - Google Patents
Abamectin slow-release granula and preparation method thereof Download PDFInfo
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- CN103960232A CN103960232A CN201410214115.0A CN201410214115A CN103960232A CN 103960232 A CN103960232 A CN 103960232A CN 201410214115 A CN201410214115 A CN 201410214115A CN 103960232 A CN103960232 A CN 103960232A
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Abstract
The invention relates to the technical field of pesticides and in particular relates to an abamectin slow-release granula and a preparation method thereof. The abamectin slow-release granula comprises abamectin, a carrier and a binder. The controlling effect of the abamectin slow-release granula provided by the invention is obviously higher than that of commercially available avermectin granules, the time of duration of pesticide effect is long, the abamectin slow-release granula has the ultra-efficient, harmfulless, residue-less, nuisanceless effects, and the like, the agricultural cost can be reduced, the preparation method is simple, and an application method is simple.
Description
Technical field
The present invention relates to technical field of pesticide, particularly a kind of Avermectin sustained-release granular formulation and preparation method thereof.
Background technology
Avermectin, English name Avermectins, by Avermectin B
1awith Avermectin B
1bmix composition, CAS is numbered 71751-41-2, and molecular formula is C
48h
72o
14(B
1a) C
47h
70o
14(B
1b), structural formula is suc as formula (Avermectin B shown in I
1a: R=CH
2cH
3; Avermectin B
1b: R=CH
3), it be by large village of university, Japanese North intelligence etc. and the class that first Merck company of the U.S. develops there is desinsection, kill mite, ten hexa-atomic Macrocyclic lactone compounds of eelworm-killing activity, produced by streptomyces griseus Streptomyces avermitilis fermentation in streptomycete, it is a kind of antibiotics insecticidal/acaricidal agent of efficient, wide spectrum, formed by one group of macrolides compound, mite class and insect are had to stomach toxicity and action of contace poison, and have faint fumigation action.What the mechanism of action of Avermectin was different from general insecticide is that it disturbs neurophysiology activity, stimulate and discharge r-aminobutyric acid, and r-aminobutyric acid has inhibitory action to arthropodan nerve conduction, after contacting with medicament with insect, there is paralysis symptom in mite class, inertia does not take food, dead after 2-4d.Because not causing that insect dewaters rapidly, so its lethal effect is slower.Avermectin has the feature of super-high-efficient, low toxicity (preparation is closely nontoxic), noresidue, the biopesticide such as nuisanceless, and the red worm of parasitism, diptera, coleoptera, Lepidoptera and pest mite etc. are all had to good effect.Along with the raising of people's living standard and the call to pollution-free food, biopesticide gains great popularity in current pesticide market, and authoritative sources predicts that 21 century is by the century that is biopesticide.Avermectin is the new product of most popular in current biopesticide market and tool keen competition.
At present, Avermectin formulation products is mainly granule, but Abamectin consumption easily causes poisoning to crop when large, and duration of efficacy is short, and the preventive effect of Abamectin can not meet the requirement of modern agricultural production.Therefore, the pesticidal preparations of provide that a kind of preventive effect is remarkable, the duration is long, safe, has important practical significance.
Summary of the invention
In view of this, the invention provides a kind of Avermectin sustained-release granular formulation and preparation method thereof.The preventive effect of Avermectin sustained-release granular formulation provided by the invention is significantly higher than commercially available Abamectin, and duration of efficacy is long, there is super-high-efficient, low toxicity, noresidue, the feature such as nuisanceless, can reduce agricultural cost, and preparation method is simple, application process is simple.
In order to realize foregoing invention object, the invention provides following technical scheme:
The invention provides a kind of Avermectin sustained-release granular formulation, comprise Avermectin, carrier and binding agent.
In the present invention, selection has the material of adsorptivity as carrier, active component Avermectin is adsorbed onto on carrier, make Avermectin sustained-release granular formulation, after it is spread fertilizer over the fields in soil, by desorb and diffusion, drug effect is slowly released, thereby the effect of active ingredient is fully played, preventive effect significantly improves, thereby can effectively prevent and treat the insects such as parasitic red worm, diptera, coleoptera, Lepidoptera.
As preferably, the weight ratio of Avermectin, carrier and binding agent is (5～30): (1～70): (1～40).
Preferably, the weight ratio of Avermectin, carrier and binding agent is 3:4:3.
As preferably, the weight percentage of Avermectin is 5%～30%.
Preferably, the weight percentage of Avermectin is 30%.
In embodiment more provided by the invention, carrier is selected from one or more the mixture in aluminium oxide, bentonite, zeolite, diatomite, sawdust or macromolecule exchanger resin.
In embodiment more provided by the invention, binding agent is selected from one or more the mixture in xanthans, sodium alginate, polyvinyl alcohol, Sodium Polyacrylate, dextrin, carboxymethyl cellulose (CMC), aluminium-magnesium silicate (SF-04) or bentonite.
The present invention also provides a kind of preparation method of Avermectin sustained-release granular formulation, comprising: get Avermectin and carrier and mix, then mix with binding agent, through granulation, be dried, sieve, to obtain final product.
As preferably, in the preparation method of Avermectin sustained-release granular formulation, the weight ratio of Avermectin, carrier and binding agent is (5～30): (1～70): (1～40).
Preferably, the weight ratio of Avermectin, carrier and binding agent is 3:4:3.
In embodiment more provided by the invention, the carrier in Avermectin sustained-release granular formulation preparation method is selected from one or more the mixture in aluminium oxide, bentonite, zeolite, diatomite, sawdust or macromolecule exchanger resin.
In embodiment more provided by the invention, the binding agent in Avermectin sustained-release granular formulation preparation method is selected from one or more the mixture in xanthans, sodium alginate, polyvinyl alcohol, Sodium Polyacrylate, dextrin, CMC, SF-04 or bentonite.
The invention provides a kind of Avermectin sustained-release granular formulation and preparation method thereof.This Avermectin sustained-release granular formulation comprises Avermectin, carrier and binding agent.Known by field efficiency test, Avermectin sustained-release granular formulation provided by the invention is compared with commercially available Abamectin, and when identical active ingredient dosage, the borer population of living after dispenser obviously reduces, and insect population decline rate is high, proofreaies and correct preventive effect and can improve 5%～35%; And along with the prolongation of time, the insect population decline rate of this Avermectin sustained-release granular formulation and correction preventive effect are without obvious decline, and in control group commercially available Abamectin control efficiency in continuous decline, the preventive effect that shows Avermectin sustained-release granular formulation provided by the invention is significantly higher than commercially available Abamectin, and duration of efficacy is long; Avermectin sustained-release granular formulation preparation method provided by the invention is simple, and application process is simple, can during plant growth, spread fertilizer over the fields; Avermectin is novel biopesticide, has super-high-efficient, low toxicity, noresidue, the feature such as nuisanceless; Avermectin sustained-release granular formulation provided by the invention can discharge completely, and drug effect is high, the duration is long, thereby has reduced agricultural cost.
Embodiment
The invention discloses a kind of Avermectin sustained-release granular formulation and preparation method thereof, those skilled in the art can use for reference content herein, suitably improve technological parameter and realize.Special needs to be pointed out is, all similar replacements and change apparent to those skilled in the artly, they are all deemed to be included in the present invention.Method of the present invention and application are described by preferred embodiment, related personnel obviously can change methods and applications as herein described in content of the present invention, spirit and scope or suitably change and combination not departing from, and realizes and apply the technology of the present invention.
In Avermectin sustained-release granular formulation provided by the invention and preparation method thereof, raw materials used medicine or auxiliary material all can be buied by market.
Below in conjunction with embodiment, further set forth the present invention:
The preparation of embodiment 1 5% Avermectin sustained-release granular formulation
5 parts of Avermectin (former medicine), 65 parts of bentonites are carried out to mix and blend, then add 30 parts of xanthans to continue to stir, add comminutor to carry out granulation in gained mixture, then drying, sieve, to obtain final product.
The preparation of embodiment 2 10% Avermectin sustained-release granular formulations
10 parts of Avermectin (former medicine), 60 parts of diatomite are carried out to mix and blend, then add 30 parts of polyvinyl alcohol to continue to stir, add comminutor to carry out granulation in gained mixture, then drying, sieve, to obtain final product.
The preparation of embodiment 3 20% Avermectin sustained-release granular formulations
20 parts of Avermectin (former medicine), 50 parts of aluminium oxide are carried out to mix and blend, then add 30 parts of sodium alginates to continue to stir, add comminutor to carry out granulation in gained mixture, then drying, sieve, to obtain final product.
The preparation of embodiment 4 30% Avermectin sustained-release granular formulations
30 parts of Avermectin (former medicine), 40 parts of zeolites are carried out to mix and blend, then add 30 parts of polypropylene sodium to continue to stir, add comminutor to carry out granulation in gained mixture, then drying, sieve, to obtain final product.
The preparation of embodiment 5 11% Avermectin sustained-release granular formulations
5 parts of Avermectin (former medicine), 1 part of sawdust are carried out to mix and blend, then add 40 parts of dextrin to continue to stir, add comminutor to carry out granulation in gained mixture, then drying, sieve, to obtain final product.
The preparation of embodiment 6 30% Avermectin sustained-release granular formulations
30 parts of Avermectin (former medicine), 70 parts of macromolecule exchanger resins are carried out to mix and blend, then add 1 part of CMC to continue to stir, add comminutor to carry out granulation in gained mixture, then drying, sieve, to obtain final product.
Embodiment 7 field efficiency tests
Get the Avermectin sustained-release granular formulation that the embodiment of the present invention 1 to 6 provides, the parasitic red worm of Kidney bean, diptera, coleoptera, Lepidoptera and pest mite are carried out to efficiency test.Test in Luoyang, henan one peasant household vegetable garden and carry out.
Experimental group and control group are set.Experimental group comprises the first experimental group to the seven experimental group; the medicament of the first experimental group is 1.5% Avermectin sustained-release granular formulation; its preparation method is with embodiment 1; be specially: 1.5 parts of Avermectin (former medicine), 68.5 parts of bentonites are carried out to mix and blend; add again 30 parts of xanthans to continue to stir; add comminutor to carry out granulation in gained mixture, then drying, sieve, to obtain final product.The 5% Avermectin sustained-release granular formulation that the medicament of the second experimental group provides for embodiment 1, the 10% Avermectin sustained-release granular formulation that the medicament of the 3rd experimental group provides for embodiment 2, the 20% Avermectin sustained-release granular formulation that the medicament of the 4th experimental group provides for embodiment 3, the 30% Avermectin sustained-release granular formulation that the medicament of the 5th experimental group provides for embodiment 4, the 11% Avermectin sustained-release granular formulation that the medicament of the 6th experimental group provides for embodiment 5, the 30% Avermectin sustained-release granular formulation that the medicament of the 7th experimental group provides for embodiment 6.
Control group comprises the first control group to the four control groups.The medicament of the first control group is clear water, the commercially available Abamectin that the medicament of the second control group is 0.5%, the commercially available Abamectin that the medicament of the 3rd control group is 1%, the commercially available Abamectin that the medicament of the 4th control group is 1.5%.
Test processing and formulation rate in table 1, dispenser after all medicaments all stir with 1 kilogram of sand.
Table 1 test is processed and formulation rate
The plot that each processing selecting water and fertilizer condition is identical, size is consistent, adopts five point samplings to investigate.Each processing repeats 4 times, records respectively the quantity of insect (the parasitic red worm of Kidney bean, diptera, coleoptera, lepidoptera pest) before dispenser with dispenser " Invest, Then Investigate ", calculates control efficiency, and computational methods are as follows:
Insect population decline rate=［ the worm amount of living before (the worm amount of living after the worm amount-medicine of living before medicine) ÷ medicine ］ × 100%
Proofread and correct preventive effect=［ (applying area insect population decline rate-check plot insect population decline rate) ÷ (1-check plot insect population decline rate) ］ × 100%
Result of the test in table 2 to table 4.
The control efficiency of 15 days after table 2 medicine
The control efficiency of 30 days after table 3 medicine
The control efficiency of 50 days after table 4 medicine
Result of the test from table 2 to table 4, the Avermectin sustained-release granular formulation that the embodiment of the present invention 1 to 6 provides is compared with commercially available Abamectin, and when identical active ingredient dosage, the borer population of living after dispenser obviously reduces, insect population decline rate is high, proofreaies and correct preventive effect and can improve 5%～35%; And along with the prolongation of time, the insect population decline rate of the Avermectin sustained-release granular formulation that the embodiment of the present invention 1 to 6 provides and correction preventive effect are without obvious decline, within after medicine 50 days, can also ensure 89.42%～93.70% correction preventive effect, and in control group commercially available Abamectin control efficiency in continuous decline, the preventive effect that shows Avermectin sustained-release granular formulation provided by the invention is significantly higher than commercially available Abamectin, and duration of efficacy is long.
The above is only the preferred embodiment of the present invention; it should be pointed out that for those skilled in the art, under the premise without departing from the principles of the invention; can also make some improvements and modifications, these improvements and modifications also should be considered as protection scope of the present invention.
Claims (10)
1. an Avermectin sustained-release granular formulation, is characterized in that, comprises Avermectin, carrier and binding agent.
2. Avermectin sustained-release granular formulation according to claim 1, is characterized in that, the weight ratio of described Avermectin, described carrier and described binding agent is (5～30): (1～70): (1～40).
3. Avermectin sustained-release granular formulation according to claim 1, is characterized in that, the weight ratio of described Avermectin, described carrier and described binding agent is 3:4:3.
4. Avermectin sustained-release granular formulation according to claim 1, is characterized in that, described carrier is selected from one or more the mixture in aluminium oxide, bentonite, zeolite, diatomite, sawdust or macromolecule exchanger resin.
5. Avermectin sustained-release granular formulation according to claim 1, is characterized in that, described binding agent is selected from one or more the mixture in xanthans, sodium alginate, polyvinyl alcohol, Sodium Polyacrylate, dextrin, CMC, SF-04 or bentonite.
6. a preparation method for Avermectin sustained-release granular formulation, is characterized in that, comprising: get Avermectin and carrier and mix, then mix with binding agent, through granulation, be dried, sieve, to obtain final product.
7. preparation method according to claim 6, is characterized in that, the weight ratio of described Avermectin, described carrier and described binding agent is (5～30): (1～70): (1～40).
8. preparation method according to claim 6, is characterized in that, the weight ratio of described Avermectin, described carrier and described binding agent is 3:4:3.
9. preparation method according to claim 6, is characterized in that, described carrier is selected from one or more the mixture in aluminium oxide, bentonite, zeolite, diatomite, sawdust or macromolecule exchanger resin.
10. preparation method according to claim 6, is characterized in that, described binding agent is selected from one or more the mixture in xanthans, sodium alginate, polyvinyl alcohol, Sodium Polyacrylate, dextrin, CMC, SF-04 or bentonite.
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| CN201410214115.0A CN103960232A (en) | 2014-05-20 | 2014-05-20 | Abamectin slow-release granula and preparation method thereof |
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| CN201410214115.0A CN103960232A (en) | 2014-05-20 | 2014-05-20 | Abamectin slow-release granula and preparation method thereof |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104430399A (en) * | 2014-11-14 | 2015-03-25 | 中国农业科学院植物保护研究所 | Preparation method and application of metalaxyl and abamectin controlled-release granules |
| CN105494326A (en) * | 2015-12-15 | 2016-04-20 | 广西田园生化股份有限公司 | Microporous sponge slow-releasing pesticide block and preparation method thereof |
| CN106234358A (en) * | 2016-07-18 | 2016-12-21 | 佛山市盈辉作物科学有限公司 | A kind of avilamycin sustained-release granular formulation |
| CN109042640A (en) * | 2018-07-19 | 2018-12-21 | 青岛正利纸业有限公司 | A kind of slow-release carrier granular and preparation method thereof |
| CN109122734A (en) * | 2018-08-31 | 2019-01-04 | 镇江鑫源达园艺科技有限公司 | A kind of sustained-release pesticides insecticide and preparation method thereof |
| CN112826825A (en) * | 2021-02-09 | 2021-05-25 | 杭州市农业科学研究院 | Environment-friendly fishery avermectin sustained-release preparation and preparation method and application thereof |
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| CN101142913A (en) * | 2007-11-02 | 2008-03-19 | 中国农业科学院植物保护研究所 | Avermectin nanometer medicine-carried system with slow-releasing and controlled-releasing action |
| CN102972439A (en) * | 2012-12-18 | 2013-03-20 | 联保作物科技有限公司 | Abamectin.fosthiazate slow-release granule and preparation method thereof |
| CN103651346A (en) * | 2013-12-20 | 2014-03-26 | 湖南化工研究院 | Benfuracarb sustained-release granule and preparation method thereof |
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2014
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101142913A (en) * | 2007-11-02 | 2008-03-19 | 中国农业科学院植物保护研究所 | Avermectin nanometer medicine-carried system with slow-releasing and controlled-releasing action |
| CN102972439A (en) * | 2012-12-18 | 2013-03-20 | 联保作物科技有限公司 | Abamectin.fosthiazate slow-release granule and preparation method thereof |
| CN103651346A (en) * | 2013-12-20 | 2014-03-26 | 湖南化工研究院 | Benfuracarb sustained-release granule and preparation method thereof |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104430399A (en) * | 2014-11-14 | 2015-03-25 | 中国农业科学院植物保护研究所 | Preparation method and application of metalaxyl and abamectin controlled-release granules |
| CN105494326A (en) * | 2015-12-15 | 2016-04-20 | 广西田园生化股份有限公司 | Microporous sponge slow-releasing pesticide block and preparation method thereof |
| CN105494326B (en) * | 2015-12-15 | 2018-02-23 | 广西田园生化股份有限公司 | A kind of microporous sponge shape sustained-release pesticides block agent and preparation method thereof |
| CN106234358A (en) * | 2016-07-18 | 2016-12-21 | 佛山市盈辉作物科学有限公司 | A kind of avilamycin sustained-release granular formulation |
| CN109042640A (en) * | 2018-07-19 | 2018-12-21 | 青岛正利纸业有限公司 | A kind of slow-release carrier granular and preparation method thereof |
| CN109122734A (en) * | 2018-08-31 | 2019-01-04 | 镇江鑫源达园艺科技有限公司 | A kind of sustained-release pesticides insecticide and preparation method thereof |
| CN112826825A (en) * | 2021-02-09 | 2021-05-25 | 杭州市农业科学研究院 | Environment-friendly fishery avermectin sustained-release preparation and preparation method and application thereof |
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