CN108350041A - 修饰的炭疽毒素保护性抗原 - Google Patents
修饰的炭疽毒素保护性抗原 Download PDFInfo
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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| US201662323218P | 2016-04-15 | 2016-04-15 | |
| US62/323,218 | 2016-04-15 | ||
| PCT/US2016/048706 WO2017035359A1 (en) | 2015-08-27 | 2016-08-25 | Modified anthrax toxin protective antigen |
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| CN108350041A true CN108350041A (zh) | 2018-07-31 |
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| EP (1) | EP3341393B1 (https=) |
| JP (1) | JP6865211B2 (https=) |
| KR (1) | KR20180073555A (https=) |
| CN (1) | CN108350041A (https=) |
| AU (1) | AU2016311429C1 (https=) |
| WO (1) | WO2017035359A1 (https=) |
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| CN117343942A (zh) * | 2023-12-06 | 2024-01-05 | 南京市食品药品监督检验院 | 一种pagA重组蛋白及其制备方法 |
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| US10835593B2 (en) | 2015-08-27 | 2020-11-17 | The United States Of America As Represented By The Secretary Department Of Health And Human Services | Modified anthrax toxin protective antigen |
| AU2019379604B2 (en) | 2018-11-16 | 2026-04-23 | Rapa Therapeutics, Llc | Als treatment using induced regulatory T (iTREG) cells |
| EP4150060A4 (en) * | 2020-05-13 | 2024-06-19 | Rapa Therapeutics, LLC | TREATMENT OR PREVENTION OF PRO-INFLAMMATORY DISEASES OR CONDITIONS USING INDUCED REGULATORY T CELLS (IT) |
| JP7648075B2 (ja) * | 2020-11-27 | 2025-03-18 | 株式会社ダイセル | 融合タンパク質 |
Citations (2)
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|---|---|---|---|---|
| US7601351B1 (en) * | 2002-06-26 | 2009-10-13 | Human Genome Sciences, Inc. | Antibodies against protective antigen |
| WO2014134187A1 (en) * | 2013-02-26 | 2014-09-04 | The Regents Of The University Of California | Compositions and methods for the treatment of cancer |
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|---|---|---|---|---|
| AU771632B2 (en) | 1999-09-24 | 2004-04-01 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Mutated anthrax toxin protective antigen proteins that specifically target cells containing high amounts of cell-surface metalloproteinases or plasminogen activator receptors |
| WO2005090393A2 (en) | 2004-02-09 | 2005-09-29 | The Government Of The United States, As Represented By The Secretary Of Health And Human Services | Multimeric protein toxins to target cells having multiple identifying characteristics |
| US20100168012A1 (en) | 2006-12-14 | 2010-07-01 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of | Human cancer therapy using engineered matrix metalloproteinase-activated anthrax lethal toxin that targets tumor vasculatuture |
| CN101215568B (zh) * | 2008-01-18 | 2010-06-23 | 畿晋庆三联（北京）生物技术有限公司 | 抗炭疽多肽及其应用与制备方法 |
| US9890369B2 (en) | 2013-06-20 | 2018-02-13 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Cytolethal distending toxin subunit B conjugated or fused to Bacillus anthracis toxin lethal factor |
| RU2016110800A (ru) * | 2013-09-25 | 2017-10-30 | Пронутриа Биосайенсис, Инк. | Составы и композиции для поддержания и увеличения мышечной массы, силы и результативности, и способы их производства и использования |
| US10835593B2 (en) | 2015-08-27 | 2020-11-17 | The United States Of America As Represented By The Secretary Department Of Health And Human Services | Modified anthrax toxin protective antigen |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7601351B1 (en) * | 2002-06-26 | 2009-10-13 | Human Genome Sciences, Inc. | Antibodies against protective antigen |
| WO2014134187A1 (en) * | 2013-02-26 | 2014-09-04 | The Regents Of The University Of California | Compositions and methods for the treatment of cancer |
Non-Patent Citations (4)
| Title |
|---|
| DIANE E. PETERS等: "Comparative toxicity and efficacy of engineered anthrax lethal toxin variants with broad anti-tumor activities", 《TOXICOLOGY AND APPLIED PHARMACOLOGY》 * |
| M. J. ROSOVITZ等: "Alanine-scanning Mutations in Domain 4 of Anthrax Toxin Protective Antigen Reveal Residues Important for Binding to the Cellular Receptor and to a Neutralizing Monoclonal Antibody", 《THE JOURNAL OF BIOLOGICAL CHEMISTRY》 * |
| MICHAEL MOUREZ等: "Mapping dominant-negative mutations of anthrax protective antigen by scanning mutagenesis", 《PNAS》 * |
| NONE: "UniProtKB-S5M0J7", 《UNIPROT DATABASE》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN117343942A (zh) * | 2023-12-06 | 2024-01-05 | 南京市食品药品监督检验院 | 一种pagA重组蛋白及其制备方法 |
| CN117343942B (zh) * | 2023-12-06 | 2024-02-13 | 南京市食品药品监督检验院 | 一种pagA重组蛋白及其制备方法 |
Also Published As
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| KR20180073555A (ko) | 2018-07-02 |
| AU2016311429A1 (en) | 2018-04-19 |
| US20180250376A1 (en) | 2018-09-06 |
| JP2018527926A (ja) | 2018-09-27 |
| EP3341393B1 (en) | 2021-03-03 |
| US10835593B2 (en) | 2020-11-17 |
| AU2016311429B2 (en) | 2021-07-08 |
| CA2996767A1 (en) | 2017-03-02 |
| AU2016311429C1 (en) | 2021-10-07 |
| JP6865211B2 (ja) | 2021-04-28 |
| WO2017035359A1 (en) | 2017-03-02 |
| EP3341393A1 (en) | 2018-07-04 |
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