CN108349943A - 杂环受限三环磺酰胺作为抗癌试剂 - Google Patents
杂环受限三环磺酰胺作为抗癌试剂 Download PDFInfo
- Publication number
- CN108349943A CN108349943A CN201680063247.5A CN201680063247A CN108349943A CN 108349943 A CN108349943 A CN 108349943A CN 201680063247 A CN201680063247 A CN 201680063247A CN 108349943 A CN108349943 A CN 108349943A
- Authority
- CN
- China
- Prior art keywords
- hydrogen
- alkyl
- optionally substituted
- aryl
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 0 CCC(C(*)C(C=C)N1C2=CC(C)(*)CC(C)(*)CC2*C(CC2)C1C[C@@]2(**)I)NS(C1CCC(C)(*)CC(*)CCCC1)(=O)=O Chemical compound CCC(C(*)C(C=C)N1C2=CC(C)(*)CC(C)(*)CC2*C(CC2)C1C[C@@]2(**)I)NS(C1CCC(C)(*)CC(*)CCCC1)(=O)=O 0.000 description 11
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562216168P | 2015-09-09 | 2015-09-09 | |
| US62/216,168 | 2015-09-09 | ||
| PCT/US2016/050685 WO2017044567A1 (en) | 2015-09-09 | 2016-09-08 | Heterocyclic constrained tricyclic sulfonamides as anti-cancer agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108349943A true CN108349943A (zh) | 2018-07-31 |
Family
ID=56940436
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680063247.5A Pending CN108349943A (zh) | 2015-09-09 | 2016-09-08 | 杂环受限三环磺酰胺作为抗癌试剂 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US10221158B2 (https=) |
| EP (1) | EP3347350A1 (https=) |
| JP (1) | JP6966425B2 (https=) |
| CN (1) | CN108349943A (https=) |
| CA (1) | CA2997769A1 (https=) |
| WO (1) | WO2017044567A1 (https=) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114272378A (zh) * | 2020-09-27 | 2022-04-05 | 四川大学华西医院 | 一种使cttnbp2nl功能缺失的试剂在制备治疗疾病的药物中的用途 |
| CN116806217A (zh) * | 2021-02-08 | 2023-09-26 | 拉帕塔疗法公司 | 蛋白磷酸酶2a(pp2a)的取代的环状调节剂及其使用方法 |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015138500A1 (en) | 2014-03-11 | 2015-09-17 | Icahn School Of Medicine At Mount Sinai | Sulfonamides derived from tricyclyl-2-aminocycloalkanols as anticancer agents |
| WO2015138496A1 (en) | 2014-03-11 | 2015-09-17 | Icahn School Of Medicine At Mount Sinai | Constrained tricyclic sulfonamides |
| CA2997784A1 (en) | 2015-09-09 | 2017-03-16 | Icahn School Of Medicine At Mount Sinai | Heterocyclic constrained tricyclic sulfonamides as anti-cancer agents |
| WO2021150695A1 (en) * | 2020-01-22 | 2021-07-29 | Icahn School Of Medicine At Mount Sinai | Constrained n-substituted tetrahydrobenzoazepine sulfonamides as anticancer and neuroprotective agents |
| US20230020161A1 (en) * | 2020-02-28 | 2023-01-19 | Rappta Therapeutics Oy | Tricyclic Modulators of PP2A |
| EP4121031A4 (en) * | 2020-03-20 | 2024-03-27 | Atux Iskay LLC | 3-DIARYLMETHYLENE AND THEIR USE |
| AU2022216880A1 (en) * | 2021-02-08 | 2023-08-10 | Rappta Therapeutics Oy | Substituted cyclic modulators of protein phosphatase 2a (pp2a) and methods using same |
| US20240368105A1 (en) | 2021-08-18 | 2024-11-07 | Atux Iskay Llc | 2-diarylmethyl-4-aminotetrahydropyran derivatives and related compounds as anticancer, antiinflammatory, antifibrotic and neuroprotective agents |
| EP4565323A1 (en) * | 2022-08-04 | 2025-06-11 | Rappta Therapeutics Oy | Aromatic compounds for use as protein phosphatase 2a (pp2a) modulators |
Family Cites Families (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4634766A (en) | 1983-10-31 | 1987-01-06 | Merck Frosst Canada, Inc. | 1,4-diaza-phenothiazines |
| GB8510680D0 (en) | 1985-04-26 | 1985-06-05 | Smith Kline French Lab | Pyridine derivatives |
| US4882351A (en) | 1987-10-14 | 1989-11-21 | Roussel Uclaf | Tricyclic compounds |
| US5834462A (en) | 1993-07-26 | 1998-11-10 | Eisai Co., Ltd. | Tricyclic heterocyclic sulfonamide and sulfonic ester derivatives |
| WO1997030038A1 (en) | 1996-02-15 | 1997-08-21 | Mitsubishi Chemical Corporation | Diarylsultam derivatives |
| US6333322B1 (en) | 1996-03-13 | 2001-12-25 | Eisai Co., Ltd. | Nitrogen-containing tricyclic compounds and drugs containing the same |
| AU2641899A (en) | 1998-02-27 | 1999-09-15 | Eisai Co. Ltd. | Heterocycle-fused benzothiazine derivatives |
| WO2002024657A2 (en) | 2000-09-20 | 2002-03-28 | Schering Corporation | Substituted imidazoles as dual histamine h1 and h3 agonists or antagonists |
| WO2003066040A1 (en) | 2002-02-05 | 2003-08-14 | Ajinomoto Co.,Inc. | Medicinal compositions containing gabapentin or pregabalin and n-type calcium channel antagonist |
| TW200400816A (en) | 2002-06-26 | 2004-01-16 | Lilly Co Eli | Tricyclic steroid hormone nuclear receptor modulators |
| EP1838690A2 (en) | 2004-12-21 | 2007-10-03 | Devgen N.V. | Compounds with kv4 ion channel activity |
| IT1362675B (it) | 2005-03-15 | 2009-06-25 | Menarini Internat Operations Luxembourg Sa | N-idrossiammidi -sostituiti con gruppi triciclici come inibitori dell'istone deacelitasi,loro preparazione ed impiego in formulazioni farmaceutiche |
| AU2006239929B2 (en) | 2005-04-22 | 2011-11-03 | Alantos Pharmaceuticals Holding, Inc. | Dipeptidyl peptidase-IV inhibitors |
| GB0508992D0 (en) | 2005-05-03 | 2005-06-08 | Novartis Ag | Organic compounds |
| CL2007003244A1 (es) | 2006-11-16 | 2008-04-04 | Millennium Pharm Inc | Compuestos derivados de pirimido[5,4-d][2]benzazepina; composicion farmaceutica que comprende a dicho compuesto; y uso del compuesto para el tratamiento del cancer. |
| WO2008121859A1 (en) | 2007-03-30 | 2008-10-09 | Xenon Pharmaceuticals Inc. | Methods of using tricyclic compounds in treating sodium channel-mediated diseases or conditions |
| HK1198384A1 (en) * | 2011-08-16 | 2015-04-17 | Mt. Sinai School Of Medicine | Tricyclic compounds as anticancer agents |
| AU2013305591B2 (en) | 2012-08-24 | 2017-04-13 | Board Of Regents Of The University Of Texas System | Pro-neurogenic compounds |
| CN102942562B (zh) | 2012-12-05 | 2014-10-01 | 天津市斯芬克司药物研发有限公司 | 一种苯并咪唑衍生物及其制备方法和应用 |
| BR112015019818A2 (pt) | 2013-02-19 | 2017-07-18 | Icahn School Med Mount Sinai | composto, uso de um composto, e, composição farmacêutica |
| WO2015138500A1 (en) | 2014-03-11 | 2015-09-17 | Icahn School Of Medicine At Mount Sinai | Sulfonamides derived from tricyclyl-2-aminocycloalkanols as anticancer agents |
| WO2015138496A1 (en) | 2014-03-11 | 2015-09-17 | Icahn School Of Medicine At Mount Sinai | Constrained tricyclic sulfonamides |
| WO2017024229A1 (en) | 2015-08-06 | 2017-02-09 | Icahn School Of Medecine At Mount Sinai | Stereospecific process for 3-heterocyclylcycloaliphatic-1,2-diols |
| WO2017044571A1 (en) | 2015-09-09 | 2017-03-16 | Icahn School Of Medicine At Mount Sinai | Tricyclic sultam sulfonamides as anticancer and neuroprotective agents |
| WO2017044572A1 (en) | 2015-09-09 | 2017-03-16 | Icahn School Of Medicine At Mount Sinai | Ring constrained diarylamino sulfonamides as anti-cancer agents |
| CA2997784A1 (en) | 2015-09-09 | 2017-03-16 | Icahn School Of Medicine At Mount Sinai | Heterocyclic constrained tricyclic sulfonamides as anti-cancer agents |
| WO2017044575A1 (en) | 2015-09-09 | 2017-03-16 | Icahn School Of Medicine At Mount Sinai | Constrained benzhydryl sulfonamides as anticancer and neuroprotective agents |
-
2016
- 2016-09-08 CA CA2997769A patent/CA2997769A1/en not_active Abandoned
- 2016-09-08 US US15/758,038 patent/US10221158B2/en active Active
- 2016-09-08 CN CN201680063247.5A patent/CN108349943A/zh active Pending
- 2016-09-08 WO PCT/US2016/050685 patent/WO2017044567A1/en not_active Ceased
- 2016-09-08 JP JP2018512944A patent/JP6966425B2/ja not_active Expired - Fee Related
- 2016-09-08 EP EP16766784.9A patent/EP3347350A1/en not_active Ceased
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114272378A (zh) * | 2020-09-27 | 2022-04-05 | 四川大学华西医院 | 一种使cttnbp2nl功能缺失的试剂在制备治疗疾病的药物中的用途 |
| CN114272378B (zh) * | 2020-09-27 | 2023-06-23 | 四川大学华西医院 | 一种使cttnbp2nl功能缺失的试剂在制备治疗疾病的药物中的用途 |
| CN116806217A (zh) * | 2021-02-08 | 2023-09-26 | 拉帕塔疗法公司 | 蛋白磷酸酶2a(pp2a)的取代的环状调节剂及其使用方法 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3347350A1 (en) | 2018-07-18 |
| WO2017044567A1 (en) | 2017-03-16 |
| CA2997769A1 (en) | 2017-03-16 |
| JP6966425B2 (ja) | 2021-11-17 |
| JP2018526416A (ja) | 2018-09-13 |
| US20180251444A1 (en) | 2018-09-06 |
| US10221158B2 (en) | 2019-03-05 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN108349943A (zh) | 杂环受限三环磺酰胺作为抗癌试剂 | |
| JP7007302B2 (ja) | メニン－ｍｌｌ相互作用の阻害剤 | |
| CN108349961B (zh) | 杂环受限三环磺酰胺作为抗癌试剂 | |
| EP3116860B1 (en) | Sulfonamides derived from tricyclyl-2-aminocycloalkanols as anticancer agents | |
| JP7091336B2 (ja) | ヒストンメチルトランスフェラーゼ阻害剤 | |
| WO2017044571A1 (en) | Tricyclic sultam sulfonamides as anticancer and neuroprotective agents | |
| WO2017044575A1 (en) | Constrained benzhydryl sulfonamides as anticancer and neuroprotective agents | |
| CN106458916A (zh) | 受限制的三环磺酰胺 | |
| WO2017044572A1 (en) | Ring constrained diarylamino sulfonamides as anti-cancer agents | |
| JP2022521818A (ja) | Ｐｒｍｔ５インヒビター及びその使用 | |
| WO2021150697A1 (en) | N-substituted-3-tricyclyl piperidine derivatives as anticancer and neuroprotective agents | |
| CN116444427A (zh) | 用于微管蛋白-src双靶点抑制剂的二芳基类化合物 | |
| CN115724830A (zh) | 作为tyk2/jak1假激酶结构域(jh2)抑制剂的化合物及合成和使用方法 | |
| CN118119607A (zh) | 作为抗癌、抗炎、抗纤维和神经保护剂的2-二芳基甲基-4-氨基四氢吡喃衍生物及相关化合物 | |
| CN113087743B (zh) | 四氢大麻酚衍生物及其制备方法和在医药上的应用 | |
| WO2021150700A1 (en) | N-substituted-3-tricyclyl piperidine derivatives as anticancer and neuroprotective agents | |
| HK1259348B (en) | Heterocyclic constrained tricyclic sulfonamides as anti-cancer agents | |
| WO2025091010A1 (en) | Organic compounds | |
| CN117820340A (zh) | Atr抑制剂及其用途 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| WD01 | Invention patent application deemed withdrawn after publication |
Application publication date: 20180731 |
|
| WD01 | Invention patent application deemed withdrawn after publication |