CN108341863A - 内皮糖蛋白多肽及其用途 - Google Patents

内皮糖蛋白多肽及其用途 Download PDF

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Publication number
CN108341863A
CN108341863A CN201810139885.1A CN201810139885A CN108341863A CN 108341863 A CN108341863 A CN 108341863A CN 201810139885 A CN201810139885 A CN 201810139885A CN 108341863 A CN108341863 A CN 108341863A
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CN
China
Prior art keywords
eng
seq
polypeptide
amino acid
endoglin polypeptide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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CN201810139885.1A
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English (en)
Chinese (zh)
Inventor
阿斯亚·格林贝格
罗斯莱因·卡斯顿盖
埃里克·维尔纳
拉温德拉·库玛
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Acceleron Pharma Inc
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Acceleron Pharma Inc
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Publication of CN108341863A publication Critical patent/CN108341863A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
    • A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/23—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a GST-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/24—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a MBP (maltose binding protein)-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/41—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a Myc-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
    • C07K2319/705—Fusion polypeptide containing domain for protein-protein interaction containing a protein-A fusion

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
CN201810139885.1A 2011-04-20 2012-04-19 内皮糖蛋白多肽及其用途 Pending CN108341863A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161477585P 2011-04-20 2011-04-20
US61/477,585 2011-04-20
CN201280030070.0A CN103781798B (zh) 2011-04-20 2012-04-19 内皮糖蛋白多肽及其用途

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201280030070.0A Division CN103781798B (zh) 2011-04-20 2012-04-19 内皮糖蛋白多肽及其用途

Publications (1)

Publication Number Publication Date
CN108341863A true CN108341863A (zh) 2018-07-31

Family

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Family Applications (3)

Application Number Title Priority Date Filing Date
CN201810139885.1A Pending CN108341863A (zh) 2011-04-20 2012-04-19 内皮糖蛋白多肽及其用途
CN201810139884.7A Expired - Fee Related CN108178789B (zh) 2011-04-20 2012-04-19 内皮糖蛋白多肽及其用途
CN201280030070.0A Expired - Fee Related CN103781798B (zh) 2011-04-20 2012-04-19 内皮糖蛋白多肽及其用途

Family Applications After (2)

Application Number Title Priority Date Filing Date
CN201810139884.7A Expired - Fee Related CN108178789B (zh) 2011-04-20 2012-04-19 内皮糖蛋白多肽及其用途
CN201280030070.0A Expired - Fee Related CN103781798B (zh) 2011-04-20 2012-04-19 内皮糖蛋白多肽及其用途

Country Status (8)

Country Link
US (3) US9932386B2 (https=)
EP (2) EP2699590B8 (https=)
JP (3) JP6250533B2 (https=)
CN (3) CN108341863A (https=)
AU (4) AU2012245439B2 (https=)
CA (1) CA2833747C (https=)
DK (1) DK2699590T3 (https=)
WO (1) WO2012145539A1 (https=)

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CN116482374A (zh) * 2022-12-12 2023-07-25 北京谱峰源生物科技有限公司 用于肝纤维化早期诊断的蛋白和检测试剂盒

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EP2739645B1 (en) * 2011-08-01 2018-12-19 Tufts Medical Center, Inc. Endoglin-specific antibody for use in a method of treating heart failure and related conditions
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US20210107959A1 (en) * 2018-01-03 2021-04-15 Acceleron Pharma Inc. Single-arm co-receptor fusion proteins and uses thereof
CN109402127B (zh) * 2018-09-29 2021-12-10 复旦大学附属眼耳鼻喉科医院 一组与结缔组织生长因子特异性结合的高亲和力核酸适配体及其应用
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KR20220021207A (ko) * 2020-08-13 2022-02-22 주식회사 나이벡 이소골 형성 부작용 경감으로 치료효과가 증진된 골형성 단백질-9, 10의 변이체 및 이를 포함하는 약학적 조성물
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Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN116482374A (zh) * 2022-12-12 2023-07-25 北京谱峰源生物科技有限公司 用于肝纤维化早期诊断的蛋白和检测试剂盒

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US20210300991A1 (en) 2021-09-30
JP2018070625A (ja) 2018-05-10
JP2020202844A (ja) 2020-12-24
CA2833747A1 (en) 2012-10-26
EP2699590B8 (en) 2019-04-17
EP3549952A1 (en) 2019-10-09
WO2012145539A1 (en) 2012-10-26
US20180258156A1 (en) 2018-09-13
AU2017201711B2 (en) 2019-04-18
US10981972B2 (en) 2021-04-20
AU2012245439B2 (en) 2017-04-06
EP2699590A1 (en) 2014-02-26
EP2699590B1 (en) 2019-02-20
AU2020244456A1 (en) 2020-10-29
JP2014513951A (ja) 2014-06-19
CN108178789B (zh) 2021-11-02
AU2017201711A1 (en) 2017-04-13
US20150307588A1 (en) 2015-10-29
JP7097930B2 (ja) 2022-07-08
CN103781798A (zh) 2014-05-07
CN103781798B (zh) 2018-03-13
JP6803315B2 (ja) 2020-12-23
CA2833747C (en) 2022-10-18
DK2699590T3 (en) 2019-05-06
CN108178789A (zh) 2018-06-19
JP6250533B2 (ja) 2017-12-20
US9932386B2 (en) 2018-04-03
AU2019204979A1 (en) 2019-08-01
AU2019204979B2 (en) 2020-07-16
AU2012245439A1 (en) 2013-11-28

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