CN108338168A - A kind of composite bactericide - Google Patents
A kind of composite bactericide Download PDFInfo
- Publication number
- CN108338168A CN108338168A CN201710053208.3A CN201710053208A CN108338168A CN 108338168 A CN108338168 A CN 108338168A CN 201710053208 A CN201710053208 A CN 201710053208A CN 108338168 A CN108338168 A CN 108338168A
- Authority
- CN
- China
- Prior art keywords
- cyano
- amino
- phenylancryic acetate
- bacterium amine
- azoles bacterium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
Abstract
The invention belongs to technical field of pesticide, it is related to a kind of composite bactericide, it is characterized in that containing fluorine indenes azoles bacterium amine and 2-cyano-3-amino-3-phenylancryic acetate two kinds of active components, the composition can be configured to the dosage forms such as suspending agent, dispersible oil-suspending agent, wettable powder, water dispersible granules, suspension seed-coating agent, with apparent synergistic effect, lasting period is long, environmentally friendly.
Description
Technical field
The invention belongs to technical field of pesticide, and in particular to a kind of compound sterilizing containing fluorine indenes azoles bacterium amine and 2-cyano-3-amino-3-phenylancryic acetate
Agent.
Background technology
Fluorine indenes azoles bacterium amine chemical name：3- difluoromethyls-N- (the fluoro- 2,3- dihydros -1,1,3- trimethyls -1H- indenes -4- of 7-
Base) -1- methyl-1 H- pyrazole-4-carboxamides, belong to wide spectrum SDHI series bactericidal agents, fungicidal spectrum covers all thifluzamides and Lu Na
Gloomy fungicidal spectrum, in addition to Rhizoctonia solani special efficacy, all to anthrax, rust, early blight, powdery mildew, leaf mold, false smut preventive effect
It very well, will be high than Lu Nasen, green prince wife's activity especially in terms of powdery mildew.Structural formula is as follows：
2-cyano-3-amino-3-phenylancryic acetate (phenamacril) is the disinfecting that Jiangsu Pesticide Research Institute Co., Ltd is independently formulated
Agent.The compound category cyanoacrylate, it is efficient, micro- poison, wide spectrum, low-residual, environmentally friendly, there is resistance of rainwater washing against energy
Power has activity extensively, and structure novel, the mode of action is unique, environmentally safe.2-cyano-3-amino-3-phenylancryic acetate caused by sickle-like bacteria to planting
Object disease have protection and therapeutic effect, absorbed by root, have on blade upwards it is translocatable, towards blade lower part and leaf
It is translocatable poor between piece, it can be applied to prevention wheat scab, bakanae disease of rice, watermelon blight etc..Structural formula is as follows：
Wheat scab is the worldwide popularity disease caused by Fusarium graminearum (Fusarium graminearum),
It is one of most important disease in China's Wheat Production.Head blight can not only cause the wheat substantially underproduction, or even total crop failure, Er Qiechi
Mildew bacterium secretion toxin --- deoxynivalenol can cause person poultry poisoning.Head blight can be sent out in wheat each breeding time
It is raw, all can be aggrieved from seedling to heading, mainly cause withered seedling, brown foot rot and fringe withered, wherein it is withered to cause harm that the most serious is fringes.
Bakanae disease of rice is also known as excessive growth disease, is caused by Fusorium moniliforme Sheldon, belongs to Deuteromycotina fungi.Each rice region of China has hair
It is raw, have the tendency that gradually aggravating in recent years, sick grain does not often germinate or cannot be unearthed after broadcasting.
Due to the use lack of standardization of current pesticide, causes disease more and more stronger to the resistance of pesticide, cause Pesticide use amount
It is higher and higher, cause the pollution of environment.Show to compound fluorine indenes azoles bacterium amine and 2-cyano-3-amino-3-phenylancryic acetate by our experimental study,
There is apparent synergistic effect in a certain range, can be good at overcoming the shortcomings of existing product, improve drug effect, reduce and use
Amount, increases economic efficiency.
Invention content
The object of the present invention is to provide a kind of composite bactericides with synergistic effect and safety and environmental protection, with existing prevention medicine
Agent is compared, and realizes the purpose for improving drug effect, reducing pollution, reducing cost.More particularly to answering for fluorine indenes azoles bacterium amine and 2-cyano-3-amino-3-phenylancryic acetate
With fungicide.
In above-mentioned composite bactericide, the weight ratio of fluorine indenes azoles bacterium amine and 2-cyano-3-amino-3-phenylancryic acetate is 1:60~60:1.
Above-mentioned composite bactericide can be configured to suspending agent, dispersible oil-suspending agent, wettable powder, water dispersible granules, hang
Floating seed coat agent.
The advantages of above-mentioned composite bactericide：1. selected dosage form safety, effect on environment is low, can be good at playing medicine
Effect；2. bactericidal effect is strong, it is not likely to produce drug resistance；3. two kinds of ingredient compoundings, there is good synergistic effect.
Specific implementation mode
For the synergistic effect of verification two kinds of active ingredient of fluorine indenes azoles bacterium amine and 2-cyano-3-amino-3-phenylancryic acetate compounding, applicant uses this first
Two kinds of ingredients have carried out indoor biometrics experiment, are wheat scab and bakanae disease of rice, test method and result for examination disease
It is as follows：
Experiment one：Reference《Farm-chemical indoor determination test rule》, it is red to wheat that medicament is measured using growth rate method
The inhibiting effect of mildew pathogen mycelia growth.On the basis of pilot study, from each medicament to germ mycelial growth inhibition rate
5 concentration are designed within the scope of up to 10%-90%, and fluorine indenes azoles bacterium amine active compound and 2-cyano-3-amino-3-phenylancryic acetate active compound are made into as solvent using acetone and are
The liquid of row concentration is spare, is then added to liquid in 1% ratio and has melted and be cooled in the PDA culture medium of room temperature, fills
Divide after shaking up, pours into the culture dish (Φ 90mm) of sterilizing and band medicine tablet is made, four repetitions are often handled, sterile water is added
Processing is blank control；With card punch (Φ 5mm) picking fusarium graminearum bacteria cake of sterilizing, the face-down aseptic inoculation of mycelia in
Center with medicine tablet is inverted in culture in 25 DEG C of constant incubator, uses crossing method measurement bacterium colony straight after cultivating 6d
Diameter calculates EC of each medicament to pathogen50, and calculate toxicity index according to the following equation, compare different agents virulence and
Bacteriostasis.
The co-toxicity of mixture preparation is indicated using the co-toxicity coefficient method of Sun Yunpei：
The mixture preparation theoretical toxicity index TTI=∑s (pharmaceutically active ingredient of the toxicity index ATI of certain medicine × in mixture
Percentage).
Co-toxicity coefficient CTC is synergistic effect when being more than 120, is antagonism when being less than 80, is when between 80-120
Addition.
The measurement result of 1 fluorine indenes azoles bacterium amine of table and 2-cyano-3-amino-3-phenylancryic acetate and its different ratio to wheat scab germ co-toxicity coefficient
Analyze above-mentioned data, it can be clearly seen that when fluorine indenes azoles bacterium amine and 2-cyano-3-amino-3-phenylancryic acetate compound in varing proportions, formula
Co-toxicity coefficient (CTC) is all higher than 120, there is the synergistic effect of different proportion to the prevention and control capability of wheat scab, when fluorine indenes azoles
Bacterium amine and 2-cyano-3-amino-3-phenylancryic acetate are 1：20~10：When 1, co-toxicity coefficient (CTC) is all higher than 135, and synergistic effect is more notable.
Experiment two：Reference《Farm-chemical indoor determination test rule》, medicament is measured using growth rate method, rice is disliked
The inhibiting effect of seedling diseases pathogen mycelia growth.On the basis of pilot study, from each medicament to germ mycelial growth inhibition rate
5 concentration are designed within the scope of up to 10%-90%, respectively match fluorine indenes azoles bacterium amine active compound and 2-cyano-3-amino-3-phenylancryic acetate active compound by solvent of acetone
It is spare at the liquid of series concentration, then liquid is added to the PDA culture medium for having melted and being cooled to room temperature in 1% ratio
In, after fully shaking up, pours into the culture dish (Φ 90mm) of sterilizing and band medicine tablet is made, four repetitions are often handled, nothing is added
The processing of bacterium water is blank control；With card punch (Φ 5mm) picking fusarium moniliforme bacteria cake of sterilizing, mycelia is sterile down
It is inoculated in the center with medicine tablet, is inverted in culture in 25 DEG C of constant incubator, is measured using crossing method after cultivating 6d
Colony diameter calculates EC of each medicament to pathogen50, and toxicity index is calculated according to the following equation, compare different agents
Virulence and bacteriostasis.
The co-toxicity of mixture preparation is indicated using the co-toxicity coefficient method of Sun Yunpei：
The mixture preparation theoretical toxicity index TTI=∑s (pharmaceutically active ingredient of the toxicity index ATI of certain medicine × in mixture
Percentage).
Co-toxicity coefficient CTC is synergistic effect when being more than 120, is antagonism when being less than 80, is when between 80-120
Addition.
The measurement result of 2 fluorine indenes azoles bacterium amine of table and 2-cyano-3-amino-3-phenylancryic acetate and its different ratio to bakanae disease of rice germ co-toxicity coefficient
Analyze above-mentioned data, it can be clearly seen that when fluorine indenes azoles bacterium amine and 2-cyano-3-amino-3-phenylancryic acetate compound in varing proportions, formula
Co-toxicity coefficient (CTC) is all higher than 120, there is the synergistic effect of different proportion to the prevention and control capability of bakanae disease of rice, when fluorine indenes azoles
Bacterium amine and 2-cyano-3-amino-3-phenylancryic acetate are 1：20~10：When 1, co-toxicity coefficient (CTC) is all higher than 136, and synergistic effect is more notable.
By indoor biometrics experiment, verifying two kinds of active ingredient compoundings of fluorine indenes azoles bacterium amine and 2-cyano-3-amino-3-phenylancryic acetate can have well
Synergistic effect, below by way of specific example to present invention be described in more detail, but the present invention be only limited to absolutely not it is following this
A little embodiments.Percentage is weight percentage in formula, and used active compound and auxiliary agent are that other producers provide.
Formulation examples are as follows：
Example 1：30.5% fluorine indenes azoles bacterium amine 2-cyano-3-amino-3-phenylancryic acetate suspending agent
Example 2：The 41% dispersible oil-suspending agent of fluorine indenes azoles bacterium amine 2-cyano-3-amino-3-phenylancryic acetate
Example 3：21% fluorine indenes azoles bacterium amine 2-cyano-3-amino-3-phenylancryic acetate wettable powder
Example 4：33% fluorine indenes azoles bacterium amine 2-cyano-3-amino-3-phenylancryic acetate suspension seed-coating agent
Example 5：24% fluorine indenes azoles bacterium amine 2-cyano-3-amino-3-phenylancryic acetate suspending agent
Example 6：30% fluorine indenes azoles bacterium amine 2-cyano-3-amino-3-phenylancryic acetate suspending agent
Example 7：30% fluorine indenes azoles bacterium amine 2-cyano-3-amino-3-phenylancryic acetate water dispersible granules
Example 8：18% fluorine indenes azoles bacterium amine 2-cyano-3-amino-3-phenylancryic acetate suspension seed-coating agent
Example 9：22% fluorine indenes azoles bacterium amine 2-cyano-3-amino-3-phenylancryic acetate water dispersible granules
Example 10：21% fluorine indenes azoles bacterium amine 2-cyano-3-amino-3-phenylancryic acetate suspending agent
Example 11：41% fluorine indenes azoles bacterium amine 2-cyano-3-amino-3-phenylancryic acetate suspending agent
Example 12：30.5% fluorine indenes azoles bacterium amine 2-cyano-3-amino-3-phenylancryic acetate suspension seed-coating agent
Experiment three：Selection above example carries out the field trial of prevention wheat scab, determines formula prevention gibberella saubinetii
The effect of disease, while by the Contrast on effect with fluorine indenes azoles bacterium amine and 2-cyano-3-amino-3-phenylancryic acetate single dose, verifying the prevention of the embodiment of the present invention
Effect.Experiment each four repetitions of processing, the random district's groups arrangement of cell processing, each plot area is 50m2, investigation method is：
Per the 5 points of samplings of cell diagonal line, the fringe of every 100 fringes of investigation~200 accounts for the percentage of entire fringe area to divide with withered fringe area
Grade records sick spike numbers at different levels and total spike number.
Computational methods：According to Disease investigation data, the disease index and control effect of each processing are calculated.
The preventive effect of 3 fluorine indenes azoles bacterium amine of table and 2-cyano-3-amino-3-phenylancryic acetate suspending agent and different agents to wheat scab
It is seen from the above data that 15 days preventive effects to wheat scab are compared more than 83% after complex preparation medicine
Two kinds of single doses of fluorine indenes azoles bacterium amine and 2-cyano-3-amino-3-phenylancryic acetate, complex preparation preventive effect highly significant；30 days after medicine, complex preparation preventive effect is up to
88%, it is seen that two kinds of active ingredient compoundings have good synergistic effect, the lasting period are extended, to the control effect of wheat scab
It is more longlasting.
Experiment four：Selection above example carries out the field trial of prevention bakanae disease of rice, determines formula prevention rice bakanae disease
The effect of disease；Simultaneously by the Contrast on effect with fluorine indenes azoles bacterium amine and 2-cyano-3-amino-3-phenylancryic acetate single dose, the prevention of the embodiment of the present invention is verified
Effect.Experiment each four repetitions of processing, the random district's groups arrangement of cell processing, each plot area is 50m2, it soaks seed 72 hours,
Then vernalization 48 hours are diluted seed dressing, manually stir evenly, and carry out artificial broadcast.Investigation method is：Investigate variant place
The seeding stage of reason investigates the emergence rate of each processing cell when the rice seedlings on seedbed all sprout；Diagonal line is pressed before shoot transplanting equipment
5 sampling surveys, the diseased plant rate and its seedling quality of every 100 plants of investigation.It is taken per random 5 points of cell before the heading of crop field
Sample, every is investigated 20 clumps, records diseased plant rate.
Computational methods：Each processing seeding stage and emergence rate are investigated, the diseased plant rate and control effect of each processing are calculated.
The preventive effect of 4 fluorine indenes azoles bacterium amine of table and 2-cyano-3-amino-3-phenylancryic acetate suspending agent and different agents to bakanae disease of rice
It is seen from the above data that complex preparation to the preventive effect of bakanae disease of rice more than 80%, compare fluorine indenes azoles bacterium
Two kinds of single doses of amine and 2-cyano-3-amino-3-phenylancryic acetate, complex preparation preventive effect significant difference, after planting 60 days, complex preparation prevented bakanae disease of rice
Effect is more than 88%, it is seen that two kinds of active ingredient compoundings have good synergistic effect, the lasting period are extended, to bakanae disease of rice
Control effect is more longlasting.Complex preparation can be very good to improve drug effect, extends the lasting period, mitigates the amount of labour of peasant, have very high
Practicability.
Claims (3)
1. a kind of composite bactericide, it is characterised in that：Active constituent is made of fluorine indenes azoles bacterium amine and 2-cyano-3-amino-3-phenylancryic acetate, the fluorine indenes azoles
The weight ratio of bacterium amine and 2-cyano-3-amino-3-phenylancryic acetate is 1：60~60：1.
2. composite bactericide according to claim 1, it is characterised in that：Suspending agent is made by active constituent and auxiliary material, can
Disperse oil-suspending agent, wettable powder, water dispersible granules, suspension seed-coating agent.
3. composite bactericide according to claim 1, it is characterised in that：To by Mastigomycotina, Ascomycotina, load
The fungus-caused multiple diseases such as bacterium subphylum, Deuteromycotina have preferable control effect, especially to wheat scab, water
The Bakanae disease of rice and all kinds of crop droops, root rot, damping-off have special efficacy.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710053208.3A CN108338168A (en) | 2017-01-22 | 2017-01-22 | A kind of composite bactericide |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710053208.3A CN108338168A (en) | 2017-01-22 | 2017-01-22 | A kind of composite bactericide |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108338168A true CN108338168A (en) | 2018-07-31 |
Family
ID=62961891
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201710053208.3A Pending CN108338168A (en) | 2017-01-22 | 2017-01-22 | A kind of composite bactericide |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104602523A (en) * | 2012-06-15 | 2015-05-06 | I-F产品协作基金会 | Synergistic compositions for the protection of agrarian crops and the use thereof |
-
2017
- 2017-01-22 CN CN201710053208.3A patent/CN108338168A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104602523A (en) * | 2012-06-15 | 2015-05-06 | I-F产品协作基金会 | Synergistic compositions for the protection of agrarian crops and the use thereof |
Non-Patent Citations (1)
| Title |
|---|
| 李恒奎 等: "氰烯菌酯防治小麦赤霉病及治理多菌灵抗药性研究", 《农药》 * |
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Application publication date: 20180731 |
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