CN108329418A - 眼用镜片材料及眼用镜片 - Google Patents
眼用镜片材料及眼用镜片 Download PDFInfo
- Publication number
- CN108329418A CN108329418A CN201710051504.XA CN201710051504A CN108329418A CN 108329418 A CN108329418 A CN 108329418A CN 201710051504 A CN201710051504 A CN 201710051504A CN 108329418 A CN108329418 A CN 108329418A
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- CN
- China
- Prior art keywords
- ophthalmic lens
- lens materials
- hydrone
- eye
- mass percentage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 239000000463 material Substances 0.000 title claims abstract description 48
- 239000000178 monomer Substances 0.000 claims abstract description 27
- 150000003839 salts Chemical class 0.000 claims abstract description 25
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 18
- 239000003999 initiator Substances 0.000 claims abstract description 15
- 239000003431 cross linking reagent Substances 0.000 claims abstract description 12
- 239000002904 solvent Substances 0.000 claims abstract description 12
- KWGKDLIKAYFUFQ-UHFFFAOYSA-M lithium chloride Chemical compound [Li+].[Cl-] KWGKDLIKAYFUFQ-UHFFFAOYSA-M 0.000 claims description 15
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 claims description 12
- -1 glycidyl ester Chemical class 0.000 claims description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 7
- TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 claims description 7
- WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 claims description 7
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 6
- FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 claims description 5
- 229940113088 dimethylacetamide Drugs 0.000 claims description 5
- 229910001629 magnesium chloride Inorganic materials 0.000 claims description 5
- HLJYBXJFKDDIBI-UHFFFAOYSA-N O=[PH2]C(=O)C1=CC=CC=C1 Chemical compound O=[PH2]C(=O)C1=CC=CC=C1 HLJYBXJFKDDIBI-UHFFFAOYSA-N 0.000 claims description 4
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 claims description 4
- 229910052710 silicon Inorganic materials 0.000 claims description 4
- 239000010703 silicon Substances 0.000 claims description 4
- 150000002825 nitriles Chemical class 0.000 claims description 3
- 239000011780 sodium chloride Substances 0.000 claims description 3
- PIZHFBODNLEQBL-UHFFFAOYSA-N 2,2-diethoxy-1-phenylethanone Chemical compound CCOC(OCC)C(=O)C1=CC=CC=C1 PIZHFBODNLEQBL-UHFFFAOYSA-N 0.000 claims description 2
- BQZJOQXSCSZQPS-UHFFFAOYSA-N 2-methoxy-1,2-diphenylethanone Chemical compound C=1C=CC=CC=1C(OC)C(=O)C1=CC=CC=C1 BQZJOQXSCSZQPS-UHFFFAOYSA-N 0.000 claims description 2
- YYPNJNDODFVZLE-UHFFFAOYSA-N 3-methylbut-2-enoic acid Chemical class CC(C)=CC(O)=O YYPNJNDODFVZLE-UHFFFAOYSA-N 0.000 claims description 2
- CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 claims description 2
- VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 claims description 2
- MHABMANUFPZXEB-UHFFFAOYSA-N O-demethyl-aloesaponarin I Natural products O=C1C2=CC=CC(O)=C2C(=O)C2=C1C=C(O)C(C(O)=O)=C2C MHABMANUFPZXEB-UHFFFAOYSA-N 0.000 claims description 2
- BLRPTPMANUNPDV-UHFFFAOYSA-N Silane Chemical compound [SiH4] BLRPTPMANUNPDV-UHFFFAOYSA-N 0.000 claims description 2
- 235000010290 biphenyl Nutrition 0.000 claims description 2
- 239000004305 biphenyl Substances 0.000 claims description 2
- AFABGHUZZDYHJO-UHFFFAOYSA-N dimethyl butane Natural products CCCC(C)C AFABGHUZZDYHJO-UHFFFAOYSA-N 0.000 claims description 2
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- LRDFRRGEGBBSRN-UHFFFAOYSA-N isobutyronitrile Chemical compound CC(C)C#N LRDFRRGEGBBSRN-UHFFFAOYSA-N 0.000 claims description 2
- WKGDNXBDNLZSKC-UHFFFAOYSA-N oxido(phenyl)phosphanium Chemical class O=[PH2]c1ccccc1 WKGDNXBDNLZSKC-UHFFFAOYSA-N 0.000 claims description 2
- MPQXHAGKBWFSNV-UHFFFAOYSA-N oxidophosphanium Chemical class [PH3]=O MPQXHAGKBWFSNV-UHFFFAOYSA-N 0.000 claims description 2
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- ZUOUZKKEUPVFJK-UHFFFAOYSA-N phenylbenzene Natural products C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims description 2
- 229910000077 silane Inorganic materials 0.000 claims description 2
- 229920005573 silicon-containing polymer Polymers 0.000 claims description 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 claims 3
- KAKZBPTYRLMSJV-UHFFFAOYSA-N Butadiene Chemical group C=CC=C KAKZBPTYRLMSJV-UHFFFAOYSA-N 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 239000003795 chemical substances by application Substances 0.000 claims 2
- RCEJCSULJQNRQQ-UHFFFAOYSA-N 2-methylbutanenitrile Chemical compound CCC(C)C#N RCEJCSULJQNRQQ-UHFFFAOYSA-N 0.000 claims 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- OKKRPWIIYQTPQF-UHFFFAOYSA-N Trimethylolpropane trimethacrylate Chemical compound CC(=C)C(=O)OCC(CC)(COC(=O)C(C)=C)COC(=O)C(C)=C OKKRPWIIYQTPQF-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 230000000977 initiatory effect Effects 0.000 claims 1
- 150000002576 ketones Chemical class 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 239000011591 potassium Substances 0.000 claims 1
- MDDUHVRJJAFRAU-YZNNVMRBSA-N tert-butyl-[(1r,3s,5z)-3-[tert-butyl(dimethyl)silyl]oxy-5-(2-diphenylphosphorylethylidene)-4-methylidenecyclohexyl]oxy-dimethylsilane Chemical compound C1[C@@H](O[Si](C)(C)C(C)(C)C)C[C@H](O[Si](C)(C)C(C)(C)C)C(=C)\C1=C/CP(=O)(C=1C=CC=CC=1)C1=CC=CC=C1 MDDUHVRJJAFRAU-YZNNVMRBSA-N 0.000 claims 1
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- 239000007864 aqueous solution Substances 0.000 abstract description 6
- 230000018044 dehydration Effects 0.000 abstract description 5
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- 208000030533 eye disease Diseases 0.000 abstract description 5
- 230000000694 effects Effects 0.000 abstract description 4
- 239000011521 glass Substances 0.000 abstract description 4
- 230000003020 moisturizing effect Effects 0.000 abstract description 4
- 208000024754 bloodshot eye Diseases 0.000 abstract description 3
- 230000008020 evaporation Effects 0.000 abstract description 3
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- 201000005111 ocular hyperemia Diseases 0.000 abstract description 3
- 210000000695 crystalline len Anatomy 0.000 description 56
- 210000001508 eye Anatomy 0.000 description 18
- 102100026735 Coagulation factor VIII Human genes 0.000 description 11
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 description 11
- WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 11
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- 150000002500 ions Chemical class 0.000 description 5
- MSXVEPNJUHWQHW-UHFFFAOYSA-N 2-methylbutan-2-ol Chemical compound CCC(C)(C)O MSXVEPNJUHWQHW-UHFFFAOYSA-N 0.000 description 4
- ZSIAUFGUXNUGDI-UHFFFAOYSA-N hexan-1-ol Chemical compound CCCCCCO ZSIAUFGUXNUGDI-UHFFFAOYSA-N 0.000 description 4
- QYPPRTNMGCREIM-UHFFFAOYSA-N methylarsonic acid Chemical compound C[As](O)(O)=O QYPPRTNMGCREIM-UHFFFAOYSA-N 0.000 description 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 3
- 239000007983 Tris buffer Substances 0.000 description 3
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 3
- 230000036571 hydration Effects 0.000 description 3
- 238000006703 hydration reaction Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- DLHQZZUEERVIGQ-UHFFFAOYSA-N 3,7-dimethyl-3-octanol Chemical class CCC(C)(O)CCCC(C)C DLHQZZUEERVIGQ-UHFFFAOYSA-N 0.000 description 2
- MXLMTQWGSQIYOW-UHFFFAOYSA-N 3-methyl-2-butanol Chemical compound CC(C)C(C)O MXLMTQWGSQIYOW-UHFFFAOYSA-N 0.000 description 2
- DBCAQXHNJOFNGC-UHFFFAOYSA-N 4-bromo-1,1,1-trifluorobutane Chemical compound FC(F)(F)CCCBr DBCAQXHNJOFNGC-UHFFFAOYSA-N 0.000 description 2
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 description 2
- XCIXKGXIYUWCLL-UHFFFAOYSA-N cyclopentanol Chemical compound OC1CCCC1 XCIXKGXIYUWCLL-UHFFFAOYSA-N 0.000 description 2
- STVZJERGLQHEKB-UHFFFAOYSA-N ethylene glycol dimethacrylate Substances CC(=C)C(=O)OCCOC(=O)C(C)=C STVZJERGLQHEKB-UHFFFAOYSA-N 0.000 description 2
- 230000004402 high myopia Effects 0.000 description 2
- 239000011259 mixed solution Substances 0.000 description 2
- SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 description 2
- 230000005477 standard model Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 1
- VTBOTOBFGSVRMA-UHFFFAOYSA-N 1-Methylcyclohexanol Chemical compound CC1(O)CCCCC1 VTBOTOBFGSVRMA-UHFFFAOYSA-N 0.000 description 1
- CAKWRXVKWGUISE-UHFFFAOYSA-N 1-methylcyclopentan-1-ol Chemical class CC1(O)CCCC1 CAKWRXVKWGUISE-UHFFFAOYSA-N 0.000 description 1
- QIGOESOMEANKQI-UHFFFAOYSA-N 1-methylcyclopentane-1,3-diol Chemical compound CC1(O)CCC(O)C1 QIGOESOMEANKQI-UHFFFAOYSA-N 0.000 description 1
- IKECULIHBUCAKR-UHFFFAOYSA-N 2,3-dimethylbutan-2-ol Chemical compound CC(C)C(C)(C)O IKECULIHBUCAKR-UHFFFAOYSA-N 0.000 description 1
- GJKGAPPUXSSCFI-UHFFFAOYSA-N 2-Hydroxy-4'-(2-hydroxyethoxy)-2-methylpropiophenone Chemical compound CC(C)(O)C(=O)C1=CC=C(OCCO)C=C1 GJKGAPPUXSSCFI-UHFFFAOYSA-N 0.000 description 1
- RIWRBSMFKVOJMN-UHFFFAOYSA-N 2-methyl-1-phenylpropan-2-ol Chemical compound CC(C)(O)CC1=CC=CC=C1 RIWRBSMFKVOJMN-UHFFFAOYSA-N 0.000 description 1
- KRIMXCDMVRMCTC-UHFFFAOYSA-N 2-methylhexan-2-ol Chemical class CCCCC(C)(C)O KRIMXCDMVRMCTC-UHFFFAOYSA-N 0.000 description 1
- WNDLTOTUHMHNOC-UHFFFAOYSA-N 3-ethylhexan-3-ol Chemical class CCCC(O)(CC)CC WNDLTOTUHMHNOC-UHFFFAOYSA-N 0.000 description 1
- JEWXYDDSLPIBBO-UHFFFAOYSA-N 3-methyl-3-octanol Chemical class CCCCCC(C)(O)CC JEWXYDDSLPIBBO-UHFFFAOYSA-N 0.000 description 1
- BESKSSIEODQWBP-UHFFFAOYSA-N 3-tris(trimethylsilyloxy)silylpropyl 2-methylprop-2-enoate Chemical compound CC(=C)C(=O)OCCC[Si](O[Si](C)(C)C)(O[Si](C)(C)C)O[Si](C)(C)C BESKSSIEODQWBP-UHFFFAOYSA-N 0.000 description 1
- RXSIKQJQLQRQQY-UHFFFAOYSA-N 4-methyloctan-4-ol Chemical class CCCCC(C)(O)CCC RXSIKQJQLQRQQY-UHFFFAOYSA-N 0.000 description 1
- NIXOWILDQLNWCW-UHFFFAOYSA-M Acrylate Chemical compound [O-]C(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-M 0.000 description 1
- 239000004342 Benzoyl peroxide Substances 0.000 description 1
- OMPJBNCRMGITSC-UHFFFAOYSA-N Benzoylperoxide Chemical compound C=1C=CC=CC=1C(=O)OOC(=O)C1=CC=CC=C1 OMPJBNCRMGITSC-UHFFFAOYSA-N 0.000 description 1
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- ZJCCRDAZUWHFQH-UHFFFAOYSA-N Trimethylolpropane Chemical compound CCC(CO)(CO)CO ZJCCRDAZUWHFQH-UHFFFAOYSA-N 0.000 description 1
- QYKIQEUNHZKYBP-UHFFFAOYSA-N Vinyl ether Chemical class C=COC=C QYKIQEUNHZKYBP-UHFFFAOYSA-N 0.000 description 1
- 235000019400 benzoyl peroxide Nutrition 0.000 description 1
- MQDJYUACMFCOFT-UHFFFAOYSA-N bis[2-(1-hydroxycyclohexyl)phenyl]methanone Chemical class C=1C=CC=C(C(=O)C=2C(=CC=CC=2)C2(O)CCCCC2)C=1C1(O)CCCCC1 MQDJYUACMFCOFT-UHFFFAOYSA-N 0.000 description 1
- 210000005252 bulbus oculi Anatomy 0.000 description 1
- 238000010382 chemical cross-linking Methods 0.000 description 1
- HPXRVTGHNJAIIH-UHFFFAOYSA-N cyclohexanol Chemical compound OC1CCCCC1 HPXRVTGHNJAIIH-UHFFFAOYSA-N 0.000 description 1
- ACUZDYFTRHEKOS-UHFFFAOYSA-N decan-2-ol Chemical compound CCCCCCCCC(C)O ACUZDYFTRHEKOS-UHFFFAOYSA-N 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- ZQTYQMYDIHMKQB-UHFFFAOYSA-N exo-norborneol Chemical compound C1CC2C(O)CC1C2 ZQTYQMYDIHMKQB-UHFFFAOYSA-N 0.000 description 1
- VOZRXNHHFUQHIL-UHFFFAOYSA-N glycidyl methacrylate Chemical compound CC(=C)C(=O)OCC1CO1 VOZRXNHHFUQHIL-UHFFFAOYSA-N 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- QNVRIHYSUZMSGM-UHFFFAOYSA-N hexan-2-ol Chemical class CCCCC(C)O QNVRIHYSUZMSGM-UHFFFAOYSA-N 0.000 description 1
- ZOCHHNOQQHDWHG-UHFFFAOYSA-N hexan-3-ol Chemical class CCCC(O)CC ZOCHHNOQQHDWHG-UHFFFAOYSA-N 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229940041616 menthol Drugs 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 230000004379 myopia Effects 0.000 description 1
- 208000001491 myopia Diseases 0.000 description 1
- MWKFXSUHUHTGQN-UHFFFAOYSA-N n-decyl alcohol Natural products CCCCCCCCCCO MWKFXSUHUHTGQN-UHFFFAOYSA-N 0.000 description 1
- CXQXSVUQTKDNFP-UHFFFAOYSA-N octamethyltrisiloxane Chemical compound C[Si](C)(C)O[Si](C)(C)O[Si](C)(C)C CXQXSVUQTKDNFP-UHFFFAOYSA-N 0.000 description 1
- NMRPBPVERJPACX-UHFFFAOYSA-N octan-3-ol Chemical class CCCCCC(O)CC NMRPBPVERJPACX-UHFFFAOYSA-N 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 description 1
- 238000004987 plasma desorption mass spectroscopy Methods 0.000 description 1
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 235000011056 potassium acetate Nutrition 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
- C08F220/26—Esters containing oxygen in addition to the carboxy oxygen
- C08F220/28—Esters containing oxygen in addition to the carboxy oxygen containing no aromatic rings in the alcohol moiety
-
- A—HUMAN NECESSITIES
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/16—Macromolecular materials obtained by reactions only involving carbon-to-carbon unsaturated bonds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F2/00—Processes of polymerisation
- C08F2/44—Polymerisation in the presence of compounding ingredients, e.g. plasticisers, dyestuffs, fillers
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F2/00—Processes of polymerisation
- C08F2/46—Polymerisation initiated by wave energy or particle radiation
- C08F2/48—Polymerisation initiated by wave energy or particle radiation by ultraviolet or visible light
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F230/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal
- C08F230/04—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal containing a metal
- C08F230/08—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and containing phosphorus, selenium, tellurium or a metal containing a metal containing silicon
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/16—Halogen-containing compounds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/04—Oxygen-containing compounds
- C08K5/09—Carboxylic acids; Metal salts thereof; Anhydrides thereof
- C08K5/098—Metal salts of carboxylic acids
-
- G—PHYSICS
- G02—OPTICS
- G02B—OPTICAL ELEMENTS, SYSTEMS OR APPARATUS
- G02B1/00—Optical elements characterised by the material of which they are made; Optical coatings for optical elements
- G02B1/04—Optical elements characterised by the material of which they are made; Optical coatings for optical elements made of organic materials, e.g. plastics
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- A—HUMAN NECESSITIES
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- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
- C08F220/10—Esters
- C08F220/26—Esters containing oxygen in addition to the carboxy oxygen
- C08F220/28—Esters containing oxygen in addition to the carboxy oxygen containing no aromatic rings in the alcohol moiety
- C08F220/281—Esters containing oxygen in addition to the carboxy oxygen containing no aromatic rings in the alcohol moiety and containing only one oxygen, e.g. furfuryl (meth)acrylate or 2-methoxyethyl (meth)acrylate
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K3/00—Use of inorganic substances as compounding ingredients
- C08K3/16—Halogen-containing compounds
- C08K2003/166—Magnesium halide, e.g. magnesium chloride
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Abstract
一种眼用镜片材料，其包含有机单体、交联剂、引发剂、盐类及溶剂，该溶剂包含水。所述眼用镜片材料中包含盐类，该盐类可以溶解在水中，分离出多个阴离子和阳离子。这些阴离子和阳离子可以键合在水分子上，该键合作用使阴离子和/或阳离子与水分子之间具有较强的结合强度，因此，在含有盐类的水溶液中，水分子蒸发时，需先破坏水分子与阴离子和/或阳离子之间的键合，才可以蒸发。因此，含有盐类的眼用镜片材料中，水分子蒸发的较慢，可以起到长久保湿的效果，使由该眼用镜片材料制得的眼用镜片长久湿润，避免眼用镜片失水引起的眼镜干涩及红眼等眼部疾病。另，本发明还涉及一种应用该眼用镜片材料制成的眼用镜片。
Description
技术领域
本发明涉及一种眼用镜片材料及应用该眼用镜片材料制得的眼用镜片。
背景技术
近年来，随着近视人群的数量越来越多，隐形眼镜因其便携、美观的特性而被广泛使用。此外，对于高度近视者一般会通过将透明晶(晶状体)全摘除，然后植入眼内镜片(人工晶状体等)，以使高度近视者可以看清物体。然而，现有的眼用镜片容易失水，从而引起眼睛干涩或发红等，使佩戴者感到不舒服，甚至引发眼部疾病。
发明内容
有鉴于此，有必要提供一种新的眼用镜片材料，以解决上述问题。
一种眼用镜片材料，其包含有机单体、交联剂、引发剂、盐类及溶剂，该溶剂包含水。
一种眼用镜片，该眼用镜片由上述眼用镜片材料制得。
本发明的眼用镜片材料中包含盐类，该盐类可以溶解在水中，从而分离出多个阴离子和阳离子。这些阴离子和阳离子可以键合在水分子上，该键合作用使得阴离子和/或阳离子与水分子之间具有较强的结合强度。此外，盐类溶解在水中，阴离子和阳离子很容易键合在水分子上，因此，水分子的离子水化度较高。在含有盐类的水溶液中，水分子蒸发的时候，需要先破坏水分子与阴离子和/或阳离子之间的键合，水分子摆脱阴离子和/或阳离子之后，才可以蒸发。因此，在含有盐类的眼用镜片材料中，水分子蒸发的较慢，可以起到长久保湿的效果，从而使由该眼用镜片材料制得的眼用镜片长久湿润，避免眼用镜片失水引起的眼镜干涩及红眼等眼部疾病。
附图说明
无
主要组件符号说明
无
具体实施方式
本发明较佳实施方式提供一种眼用镜片材料，其用于制备眼用镜片。该眼用镜片材料包含有机单体、交联剂、引发剂、盐类及溶剂。
所述眼用镜片材料中，有机单体的质量百分含量的范围为32～81％，交联剂的质量百分含量的范围为0.08～14.6％，引发剂的质量百分含量的范围为0.05～12.1％，盐类的质量百分含量的范围为3～21.5％，溶剂的质量百分含量的范围为5.5～51％。
所述有机单体包括亲水性单体。该亲水性单体包括但不限于甲基丙烯酸-2-羟基乙酯(HEMA)、甲基丙烯酸甲酯(MMA)、N,N-二甲基乙酰胺(DMA)、甲基丙烯酸缩水甘油酯(GMA)、N-乙烯基吡咯烷酮(NVP)中的一种或几种。
所述有机单体还包括有机硅单体。该有机硅单体包括但不限于甲基丙烯酰氧丙基三(三甲基硅氧烷基)硅烷(3-(METHACRYLOYLOXY)PROPYLTRIS(TRIMETHYLSILOXY)S ILANE，TRIS)及聚二甲基硅氧烷(PDMS)中的一种或两种。
所述交联剂包括但不限于二甲基丙烯酸乙二醇酯(EGDMA)、三羟甲基丙烷三甲基丙烯酸酯(TMPTMA)、三(乙二醇)二甲基丙烯酸酯(TEGDMA)、三(乙二醇)二乙烯基醚(TEGDVE)、丙二醇二甲基丙烯酸酯(TMGDMA)等常规用于制备眼用镜片的交联剂中的一种或几种。
所述引发剂可以为光引发剂或热引发剂。该光引发剂包括但不限于苯偶姻甲基醚、二乙氧基苯乙酮、苯甲酰基氧化膦类光引发剂、1-羟基环己基苯基酮、Darocure型(化工行业标准型号)光引发剂及Irgacure型(化工行业标准型号)光引发剂等常规用于制备眼用镜片的光引发剂中的一种或几种。其中，该Darocure型光引发剂优选Darocur-1173或Darocur-2959；该Irgacure型光引发剂优选Irgacure-1173；该苯甲酰基氧化膦类光引发剂包括但不仅限于2,4,6-三甲基苯甲酰基二苯基氧化膦(2,4,6-trimethylbenzoyldiphenylophosphine oxide)、双-(-二氯苯甲酰基)-4-N-丙苯基氧化膦、双-(2,6-二氯苯甲酰基)-4-N-丁苯基氧化膦中的一种或几种。所述热引发剂包括但不限于2,2’-偶氮二(2,4-二甲基戊腈)、2,2’-偶氮二(2-甲基丙腈)、2,2’-偶氮二(2-甲基丁腈)、2,2’-偶氮二异丁腈(AIBN)、过氧化物(如过氧化苯甲酰)中的一种或几种。
所述盐类包括但不限于氯化钠(NaCl)、氯化锂(LiCl)、乙酸钾(KAc)、氯化镁(MgCl2)中的一种或几种。
所述溶剂可为水或水与醇的混合液。当溶剂为水与醇的混合液的时候，该混合溶液中水与醇的体积比的范围为1％～95％。该醇包括但不限于聚乙二醇、聚丙二醇、2-丁醇、2-丙醇、薄荷醇、环己醇、环戊醇、2-戊醇、3-戊醇、2-己醇、3-己醇、3-甲基-2-丁醇、2-庚醇、2-辛醇、2-壬醇、2-癸醇、3-辛醇、降冰片、叔丁醇、叔戊醇、2-甲基-2-戊醇、2，3-二甲基-2-丁醇、3-甲基-3-戊醇、1-甲基环己醇、2-甲基-2-己醇、3，7-二甲基-3-辛醇、1-氯-2-甲基-2-丙醇、2-甲基-2-庚醇、2-甲基-2-辛醇、2-2-甲基-2-壬醇、2-甲基-2-癸醇、3-甲基-3-己醇，3-甲基-3-庚醇、4-甲基-4-庚醇、3-甲基-3-辛醇、4-甲基-4-辛醇、3-甲基-3-壬醇、4-甲基-4-壬醇、3-乙基-3-己醇、3-甲基-3-庚醇、4-乙基-4-庚醇、4-丙基-4-庚醇、4-异丙基-4-庚醇、2，4-二甲基-2-戊醇、1-甲基环戊醇、1-乙基环戊醇、4-羟基-4-甲基-1-环戊醇、2-苯基-2-丙醇、2-甲氧基-2-甲基-2-丙醇、2，3，4-三甲基-3-戊醇、3，7-二甲基-3-辛醇、2-苯基-2-丁醇、2-甲基-1-苯基-2-丙醇和3-乙基-3-戊醇、1-乙氧基-2-丙醇、1-甲基-2-丙醇、叔戊醇、异丙醇中的一种或几种。
所述眼用镜片材料中，盐类可以溶解在水中，从而分离出多个阴离子和阳离子。这些阴离子和和/或阳离子可以键合在水分子上，该键合作用使得阴离子和/或阳离子与水分子之间具有较强的结合强度。此外，盐类溶解在水中，阴离子和阳离子很容易键合在水分子上，因此，水分子的离子水化度较高。在含有盐类的水溶液中，水分子蒸发的时候，需要先破坏水分子与阴离子和/或阳离子之间的键合，摆脱阴离子和/或阳离子之后，才可以蒸发。因此，在含有盐类的眼用镜片材料中，水分子蒸发的较慢，可以起到长久保湿的效果，从而使由该眼用镜片材料制得的眼用镜片长久湿润，避免眼用镜片失水引起的眼镜干涩及红眼等眼部疾病。
一种眼用镜片，其可为隐形眼镜、眼内镜片(AIOL)等，该眼内镜片可为人工晶状体(IOLs)等。该眼用镜片由上述眼用镜片材料制得。
一种眼用镜片的制造方法，其包括以下步骤：
步骤S1，提供所述有机单体、交联剂、引发剂、盐类及溶剂，将该有机单体、交联剂、引发剂、盐类及溶剂按照预设比例混合均匀，得到混合溶液。
步骤S2，提供一眼用镜片模具，将上述混合溶液置于眼用镜片模具中。
步骤S3，对所述眼用镜片模具进行加热或紫外光照射，使所述有机单体及交联剂在引发剂的作用下发生聚合反应，形成化学交联的网络。
步骤S4，脱模并清洗，即得到眼用镜片。
下面通过实施例来对本发明进行具体说明。
实施例1
本实施例的眼用镜片材料包含HEMA、TMPTMA、Irgacure-1173、LiCl和水。
本实施例的眼用镜片材料中，HEMA的质量百分含量为53.4％，TMPTMA的质量百分含量为0.53％，Irgacure-1173的质量百分含量为0.23％，LiCl的质量百分含量为12.7％，水的质量百分含量为33.14％。
实施例2
本实施例的眼用镜片材料包含HEMA、TMPTMA、Irgacure-1173、MgCl2和水。
本实施例的眼用镜片材料中，HEMA的质量百分含量为58.34％，TMPTMA的质量百分含量为0.545％，Irgacure-1173的质量百分含量为0.254％，MgCl2的质量百分含量为12.45％，水的质量百分含量为28.411％。
实施例3
本实施例的眼用镜片材料包含有机单体、TMPTMA、AIBN、LiCl和体积比为65％的乙醇水溶液。其中，有机单体包括HEMA、MAA及NVP。
本实施例的眼用镜片材料中，HEMA的质量百分含量为52.43％、MAA的质量百分含量为0.82％、NVP的质量百分含量为1.05％，TMPTMA的质量百分含量为0.55％，AIBN的质量百分含量为0.26％，LiCl的质量百分含量为10.87％，乙醇水溶液的质量百分含量为34.01％。
实施例4
本实施例的眼用镜片材料包含有机单体、TMPTMA、Irgacure-1173、KAc和体积比为5％的乙醇水溶液。其中，有机单体包括HEMA、MAA及NVP。
本实施例的眼用镜片材料中，HEMA的质量百分含量为45.77％、MAA的质量百分含量为0.71％、NVP的质量百分含量为0.93％，TMPTMA的质量百分含量为0.49％，Irgacure-1173的质量百分含量为0.22％，KAc的质量百分含量为22.15％，乙醇水溶液的质量百分含量为29.73％。
实施例5
本实施例的眼用镜片材料包含有机单体、TMPTMA、Irgacure-1173、LiCl和95％的己醇水溶液。其中，有机单体包括HEMA、TRIS及DMA。
本实施例的眼用镜片材料中，HEMA的质量百分含量为12.1％、TRIS的质量百分含量为41.9％、DMA的质量百分含量为0.8％，TMPTMA的质量百分含量为0.38％，Irgacure-1173的质量百分含量为0.31％，LiCl的质量百分含量为11.9％，95％的己醇水溶液的质量百分含量为32.61％。
本发明的眼用镜片材料中包含盐类，该盐类可以溶解在水中，从而分离出多个阴离子和阳离子。这些阴离子和阳离子可以键合在水分子上，该键合作用使得阴离子和/或阳离子与水分子之间具有较强的结合强度。此外，盐类溶解在水中，阴离子和阳离子很容易键合在水分子上，因此，水分子的离子水化度较高。在含有盐类的水溶液中，水分子蒸发的时候，需要先破坏水分子与阴离子和/或阳离子之间的键合，水分子摆脱阴离子和/或阳离子之后，才可以蒸发。因此，在含有盐类的眼用镜片材料中，水分子蒸发的较慢，可以起到长久保湿的效果，从而使由该眼用镜片材料制得的眼用镜片长久湿润，避免眼用镜片失水引起的眼镜干涩及红眼等眼部疾病。
另外，对于本领域的普通技术人员来说，可以根据本发明的技术构思做出其它各种相应的改变与变形，而所有这些改变与变形都应属于本发明权利要求的保护范围。
Claims (10)
1.一种眼用镜片材料，其特征在于：该眼用镜片材料包含有机单体、交联剂、引发剂、盐类及溶剂，该溶剂包含水。
2.如权利要求1所述的眼用镜片材料，其特征在于：所述眼用镜片材料中，有机单体的质量百分含量的范围为32～81％，交联剂的质量百分含量的范围为0.08～14.6％，引发剂的质量百分含量的范围为0.05～12.1％，盐类的质量百分含量的范围为3～21.5％，溶剂的质量百分含量的范围为5.5～51％。
3.如权利要求1所述的眼用镜片材料，其特征在于：所述有机单体包括亲水性单体，该亲水性单体包括甲基丙烯酸-2-羟基乙酯、甲基丙烯酸甲酯、N,N-二甲基乙酰胺、甲基丙烯酸缩水甘油酯、N-乙烯基吡咯烷酮中的一种或几种。
4.如权利要求3所述的眼用镜片材料，其特征在于：所述有机单体还包括有机硅单体，该有机硅单体包括甲基丙烯酰氧丙基三(三甲基硅氧烷基)硅烷及聚二甲基硅氧烷中的一种或两种。
5.如权利要求1所述的眼用镜片材料，其特征在于：所述交联剂包括二甲基丙烯酸乙二醇酯、三羟甲基丙烷三甲基丙烯酸酯、三(乙二醇)二甲基丙烯酸酯、三(乙二醇)二乙烯基醚、及丙二醇二甲基丙烯酸酯中的一种或几种。
6.如权利要求1所述的眼用镜片材料，其特征在于：所述引发剂为光引发剂，该光引发剂包括苯偶姻甲基醚、二乙氧基苯乙酮、苯甲酰基氧化膦类光引发剂、1-羟基环己基苯基酮、Darocure型光引发剂及Irgacure型光引发剂中的一种或几种，其中，该苯甲酰基氧化膦类光引发剂包括2,4,6-三甲基苯甲酰基二苯基氧化膦、双-(-二氯苯甲酰基)-4-N-丙苯基氧化膦、双-(2,6-二氯苯甲酰基)-4-N-丁苯基氧化膦中的一种或几种。
7.如权利要求1所述的眼用镜片材料，其特征在于：所述引发剂为热引发剂，该热引发剂包括2,2’-偶氮二(2,4-二甲基戊腈)、2,2’-偶氮二(2-甲基丙腈)、2,2’-偶氮二(2-甲基丁腈)、2,2’-偶氮二异丁腈、过氧化物中的一种或几种。
8.如权利要求1所述的眼用镜片材料，其特征在于：所述盐类包括氯化钠、氯化锂、乙酸钾、氯化镁中的一种或几种。
9.如权利要求1所述的眼用镜片材料，其特征在于：所述溶剂还包含醇。
10.一种眼用镜片，其特征在于：该眼用镜片材料由权利要求1～9中任意一项所述的眼用镜片材料制得。
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Application publication date: 20180727 |