CN108323526A - A kind of special tickicide composition of gamma cyhalothrin and etoxazole compounding - Google Patents
A kind of special tickicide composition of gamma cyhalothrin and etoxazole compounding Download PDFInfo
- Publication number
- CN108323526A CN108323526A CN201810402637.1A CN201810402637A CN108323526A CN 108323526 A CN108323526 A CN 108323526A CN 201810402637 A CN201810402637 A CN 201810402637A CN 108323526 A CN108323526 A CN 108323526A
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- Prior art keywords
- tickicide
- compounding
- etoxazole
- composition
- cyhalothrin
- Prior art date
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/72—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms
- A01N43/74—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with nitrogen atoms and oxygen or sulfur atoms as ring hetero atoms five-membered rings with one nitrogen atom and either one oxygen atom or one sulfur atom in positions 1,3
- A01N43/76—1,3-Oxazoles; Hydrogenated 1,3-oxazoles
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention relates to a kind of special tickicide compositions of compounding.The compounding tickicide composition of the present invention, including surfactant, emulsifier and solvent, the wherein active ingredient of tickicide are gamma cyhalothrin and etoxazole.Dedicated tickicide drug provided by the invention can overcome the shortcomings of that polypide develops immunity to drugs, and have preferable insecticidal effect.
Description
Technical field
The present invention relates to a kind of insecticide, especially a kind of drug formed with a variety of drugs compounding for killing tick.
Background technology
Tick (Tick) is the common a kind of epizoa of animal body surface, can invade bites humans, mammal, birds,
Reptiles and amphibian animal.The harm of tick directly translates into the productivity bitten animal disturbance uneasiness and wound infection and caused
It can decline, when a large amount of parasitic, the toxin of tick secretion causes animal to be benumbed, and causes tick paralysed.In addition, tick is Lyme disease, spotted fever, Q
The communication media of the diseases such as heat, tick-borne encephalitis, Hemorrhagic fever, Babesia Gibsoni, theileriosis and anaplasmosis, in certain natures
The effect played in the property disease popularity of epidemic disease source is only second to mosquito class.Tick and tick pass sick (TTBD) and not only cause serious commercial to animal husbandry
Loss, returns human health and animal productiong brings threat, it has also become global medical field and animal doctor educational circles extraordinarily pay close attention to public
Hygienic issues.But it there is no special tickicide preparation at this stage, be applied to being all made of to prevent other insect pests for tickicide on the market
Drug.Also acaricide is used to kill tick in the prior art, but compared with tick, acarid individual is smaller, epidermis is relatively thin, such as acarid
Body size is generally all at 0.5 millimeter or so, some small to 0.1 millimeter, and most of types are less than 1 millimeter, and the tick worm of full blood
There is full soya bean size, big reachable nail cover is big, and there is the stronger scuta of chitinization at the body back side of hard tick, therefore existing
The effect that some acaricides are used to kill tick is undesirable.
Invention content
The present invention provides a kind of special tickicide composition for overcoming the shortage of prior art, being assembled by multiple compounds.
The compounding tickicide composition of the present invention, including surfactant, emulsifier and solvent, the wherein active ingredient of tickicide
For gamma cyhalothrin and etoxazole.
Gamma cyhalothrin (lambda-cyhalothrin) also known as trifluoro lambda-cyhalothrin, chemical name：3-(2-
Chloro- 3,3,3- trifluoros propenyl) -2,2- dimethyl cyclopropane carboxylic acids (alpha-cyano -3- benzene oxygen sections base ester).Chemical formula：
C23H19ClF3NO3, relative molecular weight：449.9.Gamma cyhalothrin is a kind of broad spectrum insecticide, belongs to pyrethroid and kills
Worm agent.Sodium-ion channel is acted on, the conduction at insect neural axon position is can inhibit.Main function is to tag and stomach poison function,
And there is certain repellent action.High-efficiency low-toxicity, insecticidal spectrum are wide, effect is rapid, the lasting period is long.Animal experiment does not find carcinogenic, cause
Rugged, mutagenesis[1、2]。
Etoxazole (etoxazole), chemical name：(RS) -5- tertiary butyls -2- [2- (2,6- difluorophenyls) -4,5- two
Hydrogen -1,3- oxazole -4- bases] phenetole (IUPAC), chemical formula：C21H23F2NO2, relative molecular weight：359.4, belong to 2,4- diphenyl
Oxazoline derivant class compound, main function is to tag and stomach poison function, no absorbability, but have stronger penetrating power, low
Poison, the effect lasting period is long, quick-acting is relatively slow[4].Its mechanism of action is to inhibit the normal molting process of mite and with ovicidal activity.It is dynamic
Object experiment does not find carcinogenic, teratogenesis, mutagenesis.
Complex microemulsion made of gamma cyhalothrin and etoxazole the two can be played into synergistic effect, and with more
The effect of good killing tick.
Preferably, in compounding tickicide composition of the invention the quality summation of gamma cyhalothrin and etoxazole to be sent out
The mass ratio of the 9% of bright complex composition total weight, gamma cyhalothrin and etoxazole is 6:3.
Preferably, in compounding tickicide composition of the invention：Gamma cyhalothrin is 6%, etoxazole 3%, acetic acid
Butyl ester is 5%, acetone 5%, ethylene glycol 1.5%, n-butanol 4%, agriculture breast 1600 are 6%, agriculture breast 600 is 1.5%, agriculture
Breast 500 is 5%, remaining is supplied with water.
Drug tick eradication is always the main path of prevention and control tick, and main advantages of the present invention are：The present invention provides one kind
Dedicated tickicide drug.On the other hand, pyrethroid coumpound is mostly used at present, but is repeatedly used for a long a kind of chemical drugs
Object easily makes polypide develop immunity to drugs.Compounded pesticides have apparent synergistic effect compared with folk prescription medication, and used in this experiment
Dosage form is microemulsion, has many advantages, such as to stablize, transmission efficiency height, adheres to strong, good dispersion, promotion infiltration in water, can be improved
The insecticidal effect of compounded pesticides.
Specific implementation mode
With reference to embodiment, the present invention is further illustrated.
Embodiment 1：
9% gamma cyhalothrin etoxazole missible oil
6% gamma cyhalothrin, 3% etoxazole, 5% butyl acetate, 5% acetone, 1.5% ethylene glycol, 4% positive fourth
Alcohol, 6% agriculture breast 1600,1.5% agriculture breast 600,5% agriculture breast 500, remaining supplied with water, prepare according to a conventional method.
It compares with existing drug, the present invention is characterized in：
Test method：The embodiment of the present invention uses Toxicity Determination, when experiment respectively by lambda-cyhalothrin, Sophoridine and
The mother liquor of the compounding tickicide composition of lambda-cyhalothrin and Sophoridine is diluted to 10 series concentrations, the Asia that the same day is normally fallen off
Glass eye tick full blood children's tick in continent is collected and is grouped at random, every group 10.Distinguished using the tick that external infusion process normally fell off the same day
It immerses in the different pharmaceutical of various concentration, dip time 5min, the liquid on tick surface is blotted in subsequent taking-up with blotting paper, 28
DEG C, place under conditions of relative humidity 85%, each processing sets three repetitions, to distill water process and not do the tick of any processing
As a contrast, result is observed and recorded daily.
Observed data are subjected to statistical analysis with SPSS statistical analysis softwares, the LC50 and virulence for calculating each medicament are returned
Return equation, and co-toxicity coefficient (CTC) is calculated according to the abundant equations of Sun Yun.
Calculation formula is as follows：
Worm sum × 100 living correct before the death rate (%)=(worm sum living after worm sum-medication of living before medication)/medication
The death rate (%)=(the processing group death rate-control group death rate)/(the 100- control groups death rate) × 100
Toxicity index=(standard agent LC50 values/for surveying agent LC50 values) × 100
Actual toxicity index (ATI)=standard agent LC50 values/value × 100 mixture LC50
Toxicity index × B of content (the %)+B of toxicity index × A of theoretical toxicity index (TTI)=A in mixture exists
Content (%) in mixture
Co-toxicity coefficient (CTC)=actual toxicity index (ATI)/theoretical toxicity index (TTI) × 100.
CTC ﹤ 80 are antagonism, and 80≤CTC≤120 are summation action, and CTC ﹥ 120 are synergistic effect.Measured data is shown in
Table 1 and table 2, wherein the specifically used drug prepared for the embodiment of the present invention 2.
It compares with existing drug, the present invention is characterized in：
Compounded pesticides have apparent synergistic effect compared with folk prescription medication, due to two kinds of medicines to the mechanism of action of pest not
Together, under the premise of insecticidal effect is preferable, two kinds of medicine synergy greatly reduce dosage and the drug resistance of pest.
1 gamma cyhalothrin of table and etoxazole satisfy to hyalomma asiaticum the toxicity test of blood larva
| Treatment agent | Regression equation | LC50 | 95% confidence interval | Co-toxicity coefficient |
| Gamma cyhalothrin | Y=0.4888X-0.0613 | 1.3347 | 0.4549~4.2936 | — |
| Etoxazole | Y=0.3992X-0.0318 | 1.2012 | 0.2002~10.9245 | — |
| The drug of the present invention | Y=0.5362X+0.0000 | 1.0000 | 0.2735~4.5909 | 128.83 |
2 gamma cyhalothrin of table and etoxazole satisfy to hyalomma asiaticum the test of pesticide effectiveness of blood larva
Bibliography
[1] Wang Pei orchids gamma cyhalothrin degradation bacterias separation identification and degradation property research [J] Collects The American University
[2] development of Lu Jing gamma cyhalothrins micro-capsule suspension and releasing mechanism research [J] Zhejiang industry are big
Learn
[3] the gorgeous .23% fluorine worm cyanogen azocyclotin dispersant in marquis east studies [J] coals to the field efficacy of citrus red mite
With chemical industry, 2014.
[4] the bright novelties acaricides of bright blade of a sword Cheng Zhi are worn --- the Zhejiang synthesis [J] the chemical industry of fluorine worm cyanogen, 2009.
Claims (3)
1. a kind of compounding tickicide composition, including surfactant, emulsifier and solvent, it is characterised in that wherein there is efficient chlorine fluorine
Cyano chrysanthemate and etoxazole.
2. compounding tickicide composition according to claim 1, it is characterised in that in the compounding tickicide composition efficiently
The quality summation of lambda-cyhalothrin and etoxazole is the 9% of institute's invention complex composition total weight, gamma cyhalothrin and second
The mass ratio of mite azoles is 6:3.
3. compounding tickicide composition according to claim 2, it is characterised in that in the compounding tickicide composition：Efficiently
Lambda-cyhalothrin is 6%, etoxazole 3%, butyl acetate 5%, acetone 5%, ethylene glycol 1.5%, n-butanol are
4%, agriculture breast 1600 is 6%, agriculture breast 600 is 1.5%, agriculture breast 500 is 5%, remaining is supplied with water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810402637.1A CN108323526A (en) | 2018-04-28 | 2018-04-28 | A kind of special tickicide composition of gamma cyhalothrin and etoxazole compounding |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810402637.1A CN108323526A (en) | 2018-04-28 | 2018-04-28 | A kind of special tickicide composition of gamma cyhalothrin and etoxazole compounding |
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| CN108323526A true CN108323526A (en) | 2018-07-27 |
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| CN201810402637.1A Pending CN108323526A (en) | 2018-04-28 | 2018-04-28 | A kind of special tickicide composition of gamma cyhalothrin and etoxazole compounding |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101984809A (en) * | 2010-07-22 | 2011-03-16 | 福建诺德生物科技有限责任公司 | Oil suspension preparation using resin-based vegetable oil as carrier and preparation method thereof |
| CN103098819A (en) * | 2012-12-30 | 2013-05-15 | 湖南农大海特农化有限公司 | Synergia mite-killing composite of etoxazole and efficient cyhalothrin |
| CN107691468A (en) * | 2017-12-05 | 2018-02-16 | 徐州农丰生物化工有限公司 | A kind of tebufenpyrad etoxazole Compositional acaricide and preparation method thereof |
-
2018
- 2018-04-28 CN CN201810402637.1A patent/CN108323526A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101984809A (en) * | 2010-07-22 | 2011-03-16 | 福建诺德生物科技有限责任公司 | Oil suspension preparation using resin-based vegetable oil as carrier and preparation method thereof |
| CN103098819A (en) * | 2012-12-30 | 2013-05-15 | 湖南农大海特农化有限公司 | Synergia mite-killing composite of etoxazole and efficient cyhalothrin |
| CN107691468A (en) * | 2017-12-05 | 2018-02-16 | 徐州农丰生物化工有限公司 | A kind of tebufenpyrad etoxazole Compositional acaricide and preparation method thereof |
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Application publication date: 20180727 |