CN108353926A - A kind of compounding tickicide composition - Google Patents
A kind of compounding tickicide composition Download PDFInfo
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- CN108353926A CN108353926A CN201810168443.XA CN201810168443A CN108353926A CN 108353926 A CN108353926 A CN 108353926A CN 201810168443 A CN201810168443 A CN 201810168443A CN 108353926 A CN108353926 A CN 108353926A
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- Prior art keywords
- tickicide
- compounding
- composition
- fluorine worm
- tick
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N53/00—Biocides, pest repellants or attractants, or plant growth regulators containing cyclopropane carboxylic acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having no bond to a nitrogen atom
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention relates to a kind of special tickicide compositions of compounding.The compounding tickicide composition of the present invention, including surfactant, emulsifier and solvent, the wherein active ingredient of tickicide are gamma cyhalothrin and fluorine worm cyanogen.Dedicated tickicide drug provided by the invention can overcome the shortcomings of that polypide develops immunity to drugs, and have preferable insecticidal effect.
Description
Technical field
The invention belongs to technical field of agricultural insecticide, are related to pesticide combination technology, more particularly to a kind of efficient chlorine fluorine cyanogen
Pyrethroids and fluorine worm cyanogen compound tickicide composition.
Background technology
Tick (Tick) is the common a kind of epizoa of animal body surface, can invade bites humans, mammal, birds,
Reptiles and amphibian animal.The harm of tick directly translates into the productivity bitten animal disturbance uneasiness and wound infection and caused
It can decline, when a large amount of parasitic, the toxin of tick secretion causes animal to be benumbed, and causes tick paralysed.In addition, tick is Lyme disease, spotted fever, Q
The communication media of the diseases such as heat, tick-borne encephalitis, Hemorrhagic fever, Babesia Gibsoni, theileriosis and anaplasmosis, in certain natures
The effect played in the property disease popularity of epidemic disease source is only second to mosquito class.Tick and tick pass sick (TTBD) and not only cause serious commercial to animal husbandry
Loss, returns human health and animal productiong brings threat, it has also become global medical field and animal doctor educational circles extraordinarily pay close attention to public
Hygienic issues.But it there is no special tickicide preparation at this stage, be applied to being all made of to prevent other insect pests for tickicide on the market
Drug.Also acaricide is used to kill tick in the prior art, but compared with tick, acarid individual is smaller, epidermis is relatively thin, such as acarid
Body size is generally all at 0.5 millimeter or so, some small to 0.1 millimeter, and most of types are less than 1 millimeter, and the tick worm of full blood
There is full soya bean size, big reachable nail cover is big, and there is the stronger scuta of chitinization at the body back side of hard tick, therefore existing
The effect that some acaricides are used to kill tick is undesirable.
Invention content
The present invention provides a kind of special tickicide composition for overcoming the shortage of prior art, being assembled by multiple compounds.
The compounding tickicide composition of the present invention, including surfactant, emulsifier and solvent, the wherein active ingredient of tickicide
For gamma cyhalothrin and fluorine worm cyanogen.
Gamma cyhalothrin (lambda-cyhalothrin) also known as trifluoro lambda-cyhalothrin, chemical name：3-(2-
Chloro- 3,3,3- trifluoros propenyl) -2,2- dimethyl cyclopropane carboxylic acids (alpha-cyano -3- benzene oxygen sections base ester).Chemical formula：
C23H19ClF3NO3, relative molecular weight：449.9.Gamma cyhalothrin is a kind of broad spectrum insecticide, belongs to pyrethroid and kills
Worm agent.Sodium-ion channel is acted on, the conduction at insect neural axon position is can inhibit.Main function is to tag and stomach poison function,
And there is certain repellent action.High-efficiency low-toxicity, insecticidal spectrum are wide, effect is rapid, the lasting period is long.Animal experiment does not find carcinogenic, cause
Rugged, mutagenesis[1、2]。
Fluorine worm cyanogen (Fipronil), chemical name：(RS) -5- amino -1- (2,6- dichlor-4-trifluoromethyls phenyl) -4-
Trifluoromethyl sulfinyl pyrazole -3- nitriles, chemical formula：C12H4Cl2F6N4OS, relative molecular weight：437.151 being a kind of phenyl pyrazoline
Azole pesticides, insecticidal spectrum is wide, have to insect pest tag, stomach toxicity and certain systemic action, insect pest γ-aminobutyric acid can be blocked
With the chloride channel of glutamate-induced, insect pest central nervous system is set to be overexcited and dead.
Compounded cream can play synergistic effect made of above-mentioned two kinds of drugs.
Preferably, in compounding tickicide composition of the invention the quality summation of gamma cyhalothrin and fluorine worm cyanogen to be sent out
The 9% of bright complex composition total weight, and the mass ratio of gamma cyhalothrin and fluorine worm cyanogen is 8.
Preferably, in compounding tickicide composition of the invention：Gamma cyhalothrin is 8%, fluorine worm cyanogen is 1%, second
Acid butyl ester is 5%, acetone 5%, ethylene glycol 1.5%, n-butanol 4%, agriculture breast 1600 are 6%, agriculture breast 600 is 1.5%,
Agriculture breast 500 is 5%, remaining is supplied with water.
It compares with existing drug, main advantages of the present invention are：
Drug tick eradication is always the main path of prevention and control tick, and the present invention provides a kind of dedicated tickicide drugs.Another party
Face mostly uses pyrethroid coumpound at present, but being repeatedly used for a long a kind of chemicals easily makes polypide develop immunity to drugs.
Compounded pesticides have apparent synergistic effect compared with folk prescription medication, since two kinds of medicines are different to the mechanism of action of tick：Efficient chlorine fluorine
Cyano chrysanthemate mainly acts on sodium-ion channel, can inhibit the conduction at tick neural axon position, and fluorine worm cyanogen mainly acts on chlorion
Channel makes tick central nervous system be overexcited and dead.Under the premise of insecticidal effect is preferable, two kinds of medicine synergy, significantly
Reduce dosage and the drug resistance of insect pest.And dosage form used in this experiment is microemulsion, have stablize, transmission efficiency is high,
The advantages that attachment is strong, good dispersion, promotion are permeated in water, can be improved the insecticidal effect of compounded pesticides.
Specific implementation mode
With reference to embodiment, the present invention is further illustrated.
Embodiment 1：9% gamma cyhalothrin fluorine worm cyanogen cream
The present embodiment each component and mass ratio are：8% gamma cyhalothrin, 1% fluorine worm cyanogen, 5% butyl acetate, 5%
Acetone, 1.5% ethylene glycol, 4% n-butanol, 6% agriculture breast 1600,1.5% agriculture breast 600,5% agriculture breast 500, remaining supplied with water,
It prepares according to a conventional method.
Test method：The embodiment of the present invention uses Toxicity Determination, when experiment respectively by lambda-cyhalothrin, fluorine worm cyanogen and
The mother liquor of lambda-cyhalothrin and the compounding tickicide composition of fluorine worm cyanogen is diluted to 10 series concentrations, the Asia that the same day is normally fallen off
Glass eye tick full blood children's tick in continent is collected and is grouped at random, every group 10.Distinguished using the tick that external infusion process normally fell off the same day
It immerses in the different pharmaceutical of various concentration, dip time 5min, the liquid on tick surface is blotted in subsequent taking-up with blotting paper, 28
DEG C, place under conditions of relative humidity 85%, each processing sets three repetitions, to distill water process and not do the tick of any processing
As a contrast, result is observed and recorded daily.
Observed data are subjected to statistical analysis with SPSS statistical analysis softwares, the LC50 and virulence for calculating each medicament are returned
Return equation, and co-toxicity coefficient (CTC) is calculated according to the abundant equations of Sun Yun, calculation formula is as follows：The death rate (%)=(living before medication
Worm sum living after worm sum-medication) corrected mortality (%) of worm sum living before/medication × 100=(the processing group death rate-right
According to a group death rate)/(the 100- control groups death rate) × 100
Toxicity index=(standard agent LC50 values/for surveying agent LC50 values) × 100
Actual toxicity index (ATI)=standard agent LC50 values/value × 100 mixture LC50
Toxicity index × B of content (the %)+B of toxicity index × A of theoretical toxicity index (TTI)=A in mixture exists
Content (%) in mixture
Co-toxicity coefficient (CTC)=actual toxicity index (ATI)/theoretical toxicity index (TTI) × 100.
CTC ﹤ 80 are antagonism, and 80≤CTC≤120 are summation action, and CTC ﹥ 120 are synergistic effect.
The composition of the present invention kills the experimental result for carrying out the full blood larva of hyalomma asiaticum referring to table 1 and table 2, wherein used be
Drug described in embodiment 2.
It compares with existing drug, the present invention is characterized in：
Compounded pesticides have apparent synergistic effect compared with folk prescription medication, due to two kinds of medicines to the mechanism of action of pest not
Together, under the premise of insecticidal effect is preferable, two kinds of medicine synergy greatly reduce dosage and the drug resistance of pest.
The experimental result of 1 gamma cyhalothrin of table and the full blood larva of fluorine worm cyanogen prevention hyalomma asiaticum
| Treatment agent | Regression equation | LC50 | 95% confidence interval | Co-toxicity coefficient |
| Gamma cyhalothrin | Y=0.4887X-0.0613 | 1.3347 | 0.4549~4.2936 | — |
| Fluorine worm cyanogen | Y=0.3504X+0.2728 | 0.1665 | 0.0300~1.4244 | — |
| The drug of the present invention | Y=0.5047X+0.3257 | 0.2263 | 0.0408~1.5201 | 331.58 |
The experimental result of 2 gamma cyhalothrin of table and the full blood larva of fluorine worm cyanogen prevention hyalomma asiaticum
Bibliography
[1] Wang Pei orchids gamma cyhalothrin degradation bacterias separation identification and degradation property research [J] Collects The American University
[2] development of Lu Jing gamma cyhalothrins micro-capsule suspension and releasing mechanism research [J] Zhejiang industry are big
Learn
[3] the gorgeous .23% fluorine worm cyanogen azocyclotin dispersant in marquis east studies [J] coals to the field efficacy of citrus red mite
With chemical industry, 2014.
[4] the bright novelties acaricides of bright blade of a sword Cheng Zhi are worn --- the Zhejiang synthesis [J] the chemical industry of fluorine worm cyanogen, 2009.
Claims (3)
1. a kind of compounding tickicide composition, including surfactant, emulsifier and solvent, it is characterised in that wherein there is efficient chlorine fluorine
Cyano chrysanthemate and fluorine worm cyanogen.
2. compounding tickicide composition according to claim 1, it is characterised in that in the compounding tickicide composition efficiently
The quality summation of lambda-cyhalothrin and fluorine worm cyanogen be the 9% of institute's invention complex composition total weight, and gamma cyhalothrin and
The mass ratio of fluorine worm cyanogen is 8.
3. compounding tickicide composition according to claim 2, it is characterised in that in the compounding tickicide composition：Efficiently
Lambda-cyhalothrin is 8%, fluorine worm cyanogen is 1%, butyl acetate 5%, acetone 5%, ethylene glycol 1.5%, n-butanol are
4%, agriculture breast 1600 is 6%, agriculture breast 600 is 1.5%, agriculture breast 500 is 5%, remaining is supplied with water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810168443.XA CN108353926A (en) | 2018-02-28 | 2018-02-28 | A kind of compounding tickicide composition |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810168443.XA CN108353926A (en) | 2018-02-28 | 2018-02-28 | A kind of compounding tickicide composition |
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| Publication Number | Publication Date |
|---|---|
| CN108353926A true CN108353926A (en) | 2018-08-03 |
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| CN201810168443.XA Pending CN108353926A (en) | 2018-02-28 | 2018-02-28 | A kind of compounding tickicide composition |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1836513A (en) * | 2005-03-21 | 2006-09-27 | 安徽华星化工股份有限公司 | Mixed insecticide composition containing fipronil |
| CN1947514A (en) * | 2006-11-05 | 2007-04-18 | 深圳诺普信农化股份有限公司 | Pesticide of synergistic effect contg. fipronil and cyfluthrin |
| CN103891756A (en) * | 2012-12-30 | 2014-07-02 | 青岛锦涟鑫商贸有限公司 | Fipronil-containing composition insecticide |
-
2018
- 2018-02-28 CN CN201810168443.XA patent/CN108353926A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1836513A (en) * | 2005-03-21 | 2006-09-27 | 安徽华星化工股份有限公司 | Mixed insecticide composition containing fipronil |
| CN1947514A (en) * | 2006-11-05 | 2007-04-18 | 深圳诺普信农化股份有限公司 | Pesticide of synergistic effect contg. fipronil and cyfluthrin |
| CN103891756A (en) * | 2012-12-30 | 2014-07-02 | 青岛锦涟鑫商贸有限公司 | Fipronil-containing composition insecticide |
Non-Patent Citations (1)
| Title |
|---|
| 卢海燕 等: "二十八种药物对亚洲璃眼蜱杀灭效果的观察", 《中国兽医科学》 * |
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