CN108310063A - A kind of composition and products thereof for treating angular stomatitis - Google Patents
A kind of composition and products thereof for treating angular stomatitis Download PDFInfo
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- CN108310063A CN108310063A CN201810244311.0A CN201810244311A CN108310063A CN 108310063 A CN108310063 A CN 108310063A CN 201810244311 A CN201810244311 A CN 201810244311A CN 108310063 A CN108310063 A CN 108310063A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/455—Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A61K31/51—Thiamines, e.g. vitamin B1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/525—Isoalloxazines, e.g. riboflavins, vitamin B2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
Abstract
The present invention relates to technical field of pharmaceuticals, and in particular to a kind of composition and products thereof for treating angular stomatitis.Including Chinese medicine and Western medicine, Chinese medicine includes the pulvis or extracting solution of radix scutellariae and Fructus Forsythiae；Western medicine includes VB2Pulvis or equivalent pulvis prepare solution.The medicine is combined using Chinese and Western, compares traditional oral medication, and the medicament that the composition is prepared can be used for being applied with, and has very strong specific aim by external application; precise guidance directs at the cause of disease, and affected part is spread on using application; affected part mucous membrane can be kept to moisten, and can fix and protect bicker, improve resume speed.
Description
Technical field
The present invention relates to technical field of pharmaceuticals, and in particular to a kind of composition and products thereof for treating angular stomatitis.
Background technology
Angular stomatitis is commonly called as " angular chilitis ", show as bicker flush, blister, chap, erosion, incrustation, furfur etc..Patient dehisces
U.S. is hindered in easy bleeding, all effected of speaking of having a meal, or even the words that dare not dehisce to have a meal, do not dare to say aloud, damaged bicker of forming a scab again
It sees, seriously affects the quality of working life and physical and mental health.At present China for angular stomatitis treatment with oral antibiotic, Chinese medicine,
Based on VB preparations, but in the prevalence of slowly effect, protracted inflammation, antibiotic cause drug-fast bacteria spread unchecked and oral medication through cycle point
Cloth whole body injures phenomena such as normal body function.So clinical urgently call a kind of new drug, new paragon to replace traditional treatment
Mode.Angular stomatitis has the three big causes of disease：One, cold dry weather can make lip, bicker surrounding skin mucous membrane dry and cracked, and skin and mucosa is anti-
Imperial power declines, and easy pathogenic bacteria, which are taken advantage of a weak point, to be caused to infect, so autumn and winter, which is angular stomatitis again, often sends out period；Two, lip is dry and cracked
When, people usually habitually can go to lick with tongue, it is desirable to moisten bicker, affected part moisture steaming can be aggravated by hardly realizing this measure instead
Hair, or even oral bacteria is brought to dry and cracked place, to mass propagation；If the vitamin three, absorbed from diet is reduced, body is caused
Interior B family vitamin lacks, and will lead to the generation of Vitamin B deficiency angular stomatitis.
For the angular stomatitis problem that above-mentioned three kinds of reasons generate, conventional at present is by feeding related nutritional food and medicine
Product are but slower by the method effect of feed to improve inflammation, cannot alleviate the pain of patient in time.
Invention content
The purpose of the present invention is to solve the above problems, provide a kind of composition and products thereof for treating angular stomatitis.
Composition provided by the invention, can be restorative by will be applied to outside this product mainly for current angular stomatitis
Purpose.The present invention also provides a kind of product, which is convenient for forming the matured product for the treatment of using the composition provided, with side
Just the use of patient.
In order to reach foregoing invention purpose, the present invention uses following technical scheme：
A kind of composition for treating angular stomatitis, including Chinese medicine and Western medicine, Chinese medicine include the pulvis or extracting solution of radix scutellariae and Fructus Forsythiae；West
Medicine includes VB2Pulvis or equivalent pulvis prepare solution.
Preferably, the radix scutellariae 5-15g, Fructus Forsythiae 5-15g.
Preferably, the VB2For 6.25-18.75mg.
Preferably, the Chinese medicine further includes the pulvis or extracting solution of peppermint and/or Radix Notoginseng.
Preferably, the Radix Notoginseng is 0.5-3.5g, peppermint 2-8g.
Preferably, the Western medicine further includes VC, VB1、VB3And VB5At least one of, wherein when more than a kind of, each group
Point it is pulvis or is solution that equivalent pulvis is prepared or constituent part be pulvis constituent part is solution.
Preferably, described VC, VB1、VB3And VB5Amount ranges be 6.25-18.75mg.
Preferably, the preparation method of the extracting solution is：Each Chinese medicine is impregnated with normal-temperature water, Chinese medicine impregnates
30min, medicinal powder impregnates 10min, and when having Radix Notoginseng, 10min first is decocted in Radix Notoginseng big fire, then is included in other drugs small fire and decocts 10min,
Extract effective water-soluble composition.
Preferably, further include physiological saline, the addition of physiological saline makes the concentration range of each western medicine component be 3-60mg/
mL。
The pathogenic factor of angular stomatitis is more miscellaneous, restores relatively slow by way of tonic at present, in order to improve current situation, warp
The discovery of inventor's research experiment is crossed, using Integrated TCM, can effectively accelerate the resume speed of angular stomatitis patient.And it sends out
It is respectively radix scutellariae, Fructus Forsythiae that a person of good sense, which studies the Chinese medicine found in specific Chinese and Western medicine, is assisted with peppermint and Radix Notoginseng, Western medicine VB2, auxiliary
Auxiliary agent is respectively VC, VB1、VB3And VB5, Integrated TCM is used, and is carried out in the form of being applied with, an anti-convention
It is for oral administration.It using above-mentioned Integrated TCM and is applied with, can effectively and rapidly cure angular stomatitis, to reduce the pain of patient
It is bitter.
Specifically, Chinese medicine therein uses pulvis or extracting solution, more preferably with extracting solution；And the various vitamins in Western medicine
Using pulvis or solution, when using solution, the usage amount of subsequent physiological saline can be reduced.
About above-mentioned used Chinese medicine, peppermint, radix scutellariae, Fructus Forsythiae and Radix Notoginseng are more typical medicinal material.Wherein, radix scutellariae pair
Bacterium has wider antimicrobial spectrum, in vitro to shigella dysenteriae, corynebacterium diphtheriae, Pseudomonas aeruginosa, staphylococcus, streptococcus, pneumonia
Diplococcus and meningococcus etc. have inhibiting effect, decoction to make larynx spraying, and to meningitis, carrier is also effective, even if right
It is sensitive still to belong to radix scutellariae for the staphylococcus aureus that the antibiotic such as penicillin have developed immunity to drugs.Also have simultaneously it is relatively strong it is antimycotic,
It is antiviral.Fructus Forsythiae have more thoroughly and also stablize antibacterial action Volatile Oil of Forsythia Suspensa Seeds emulsion is measured again with test tube dilution method into
As a result row antibacterial tests show the medicine in addition to slightly lower to Pseudomonas aeruginosa effect, to other 10 plants of Gram-positives and negative bacteria
There is stronger antibacterial action.
Chinese medicine angle, it is Dicang point that 0.5 cun is opened by bicker, and the storehouse of dicang person's trough is reported, also the bright stomach of ownership sun.Stomach
It receives hundred paddy and decomposed, is risen on essence derived from food, flourish face-beautifying noodle, if there is fire to have heresy in stomach, and most easily injure the weak place of mucous membrane for example mouth
Angle can be set a prairie fire in a moment as Mars is thrown in silo.Surface skin mucous membrane, fur, fur person, lung master it, stomach category
Soil, the lung belonging to metal, soil can give birth to gold, be and mother that stomach is lung, and doctor must can hear the two of one, it should be understood that the sick biography of mother is sub, stomach trouble can pass in
Lung.Therefore medication can not be biased, must use the medicine of lung stomach, the medicine of middle upper and middle portions of the body cavity.Radix scutellariae, peppermint enter the bright stomach of sun, lunar lung channel,
Power reaches middle upper and middle portions of the body cavity, and two medicines are shared with clearing heat and detoxicating, opens strongly fragrant except dirty and other effects；Radix scutellariae, Fructus Forsythiae share and can reinforce detumescence and treat
The effect of sore；Radix Notoginseng can hemostasia and promoting granulation promote mucous membrane healing, the effect of can reinforcing anti-inflammatory analgetic is shared with peppermint.
Present invention utilizes Chinese medicine, peppermint, radix scutellariae, Fructus Forsythiae and Radix Notoginseng compatibility effect, to being controlled at the morbidity of patient
It treats, in combination with the effect of each Western medicine, replenishing vitamins lack, and promote affected part mucous membrane tissue healing, to hypovitaminosis
Caused angular stomatitis forms the effect for the treatment of both manifestation and root cause of disease.
When preparing extracting solution, obtained with the traditional Chinese medicine extraction of equivalent pulvis.
A kind of product using above-mentioned composition, the product are specially：The composition is carried in application and is prepared
It forms.Application is that benzalkonium bromide pastes.
A kind of application method of composition that treating angular stomatitis specially takes the 1/100-1/ of the total composition after preparing
50 are applied with.
Compared with prior art, the present invention advantageous effect is：Compare traditional oral medication, the medicament that the composition is prepared
It can be used for being applied with, there is very strong specific aim by external application, precise guidance directs at the cause of disease, simultaneously as topical remedy is dense
Degree is significantly larger than oral medication, small to body systemic effects；It is convenient and efficient.And carry out the composition in the form of application
Words, it may have convenient and efficient advantage is sticked before sleeping, taken off from morning, do not interfere daily life；The medicament of moistening sticks
In affected part, you can keep affected part mucous membrane moistening, and can fix and protect bicker, improve resume speed.
Specific implementation mode
Explanation is further described to technical scheme of the present invention below by specific embodiment.
If without specified otherwise, the raw material employed in the embodiment of the present invention is raw material commonly used in the art, is implemented
Method employed in example, is the conventional method of this field.
Embodiment 1：（It is formulated A）
A kind of composition for treating angular stomatitis, including Chinese medicine and Western medicine, Chinese medicine include the pulvis of radix scutellariae, Fructus Forsythiae；Western medicine VB2, VB3
Pulvis.The Chinese medicine includes radix scutellariae 15g, Fructus Forsythiae 15g.VB2 is 18.75mg, VB3 18.75mg, is eventually adding physiological saline
The concentration range for being adjusted to each vitamin is 60mg/mL.
When in use, each component is sufficiently mixed for the composition, after then taking above-mentioned composition to prepare outside the 1/100 of total amount
It applies.Or by above-mentioned composition be carried on application on be prepared into application product be applied with.
Embodiment 2：Formula（B）
A kind of composition for treating angular stomatitis, including Chinese medicine and Western medicine, Chinese medicine include the extracting solution of radix scutellariae, Fructus Forsythiae；Western medicine VB2,
The pulvis of VB3.The Chinese medicine includes radix scutellariae 5g, Fructus Forsythiae 5g.VB2 is 6.25mg, VB3 6.25mg, is eventually adding physiological saline
The concentration range for being adjusted to each vitamin is 3mg/mL.
When in use, each component is sufficiently mixed for the composition, after then taking above-mentioned composition to prepare outside the 1/100 of total amount
It applies.Or by above-mentioned composition be carried on application on be prepared into application product be applied with.
The extracting solution is formed using equivalent traditional Chinese medicine extraction, and specific preparation method is：By each Chinese medicine with room temperature water logging
Bubble, Chinese medicine impregnate 30min, and medicinal powder impregnates 10min, and after water is opened, small fire decocts 10min, extracts effective water-soluble composition.
When in use, each component is sufficiently mixed for the composition, after then taking above-mentioned composition to prepare outside the 1/100 of total amount
It applies.Or by above-mentioned composition be carried on application on be prepared into application product be applied with.
Embodiment 3：（It is formulated C）
A kind of composition for treating angular stomatitis, including Chinese medicine and Western medicine, Chinese medicine include radix scutellariae, Fructus Forsythiae, peppermint and the pulvis of Radix Notoginseng；
Western medicine includes the pulvis of VC, VB1, VB2, VB3 and VB5 or the solution that equivalent pulvis is prepared.
The baikal skullcap root 6g, Fructus Forsythiae 9g, Radix Notoginseng 0.5g, peppermint 2g.
VC is 6.25mg, VB1 6.25mg, VB2 6.25mg, VB3 are 6.25mg and VB5 is 6.25mg, is eventually adding
The concentration range that physiological saline is adjusted to each vitamin is 6mg/mL.
The extracting solution is formed using equivalent traditional Chinese medicine extraction, and specific preparation method is：By each Chinese medicine with room temperature water logging
Bubble, Chinese medicine impregnate 30min, and medicinal powder impregnates 10min, and 10min first is decocted in Radix Notoginseng big fire, then are included in the decoction of other drugs small fire
10min extracts effective water-soluble composition.
When in use, each component is sufficiently mixed for the composition, after then taking above-mentioned composition to prepare outside the 1/100 of total amount
It applies.Or by above-mentioned composition be carried on application on be prepared into application product be applied with.
Embodiment 4：（It is formulated D）
A kind of composition for treating angular stomatitis, including Chinese medicine and Western medicine, Chinese medicine include radix scutellariae, Fructus Forsythiae, peppermint and the extraction of Radix Notoginseng
Liquid；Western medicine includes the pulvis of VC, VB1, VB2, VB3 and VB5 or the solution that equivalent pulvis is prepared.
The baikal skullcap root 15g, Fructus Forsythiae 15g, Radix Notoginseng 3.5g, peppermint 8g.
VC is 6.25mg, VB1 6.25mg, VB2 18.75mg, VB3 are 18.75mg and VB5 is 18.75mg, is finally added
It is 6mg/mL to enter physiological saline to be adjusted to the concentration range of each vitamin.
The extracting solution is formed using equivalent traditional Chinese medicine extraction, and specific preparation method is：By each Chinese medicine with room temperature water logging
Bubble, Chinese medicine impregnate 30min, and medicinal powder impregnates 10min, and 10min first is decocted in Radix Notoginseng big fire, then are included in the decoction of other drugs small fire
10min extracts effective water-soluble composition.
When in use, each component is sufficiently mixed for the composition, after then taking above-mentioned composition to prepare outside the 1/100 of total amount
It applies.Or by above-mentioned composition be carried on application on be prepared into application product be applied with.
Embodiment 5：（It is formulated E）
A kind of composition for treating angular stomatitis, including Chinese medicine and Western medicine, Chinese medicine include radix scutellariae, Fructus Forsythiae, peppermint and the pulvis of Radix Notoginseng；
Western medicine includes the pulvis of VC, VB1, VB2, VB3 and VB5 or the solution that equivalent pulvis is prepared.
The baikal skullcap root 10g, Fructus Forsythiae 8g, Radix Notoginseng 0.5g, peppermint 8g.
VC is 6.25mg, VB1 18.75mg, VB2 6.25mg, VB3 are 18.75mg and VB5 is 6.25mg, is finally added
It is 40mg/mL to enter physiological saline to be adjusted to the concentration range of each vitamin.
The extracting solution is formed using equivalent traditional Chinese medicine extraction, and specific preparation method is：By each Chinese medicine with room temperature water logging
Bubble, Chinese medicine impregnate 30min, and medicinal powder impregnates 10min, and 10min first is decocted in Radix Notoginseng big fire, then are included in the decoction of other drugs small fire
10min extracts effective water-soluble composition.
When in use, each component is sufficiently mixed for the composition, the 1/100- of total amount after then taking above-mentioned composition to prepare
1/50 is applied with.Or by above-mentioned composition be carried on application on be prepared into application product be applied with.
Embodiment 6：（It is formulated F）
A kind of composition for treating angular stomatitis, including Chinese medicine and Western medicine, Chinese medicine include radix scutellariae, Fructus Forsythiae, peppermint and the extraction of Radix Notoginseng
Liquid；Western medicine includes the pulvis of VC, VB1, VB2, VB3 and VB5 or the solution that equivalent pulvis is prepared.
The baikal skullcap root 7g, Fructus Forsythiae 12g, Radix Notoginseng 3.5g, peppermint 2g.
VC is 18.75mg, VB1 6.25mg, VB2 18.75mg, VB3 are 6.25mg and VB5 is 18.75mg, is finally added
It is 30mg/mL to enter physiological saline to be adjusted to the concentration range of each vitamin.
The extracting solution is formed using equivalent traditional Chinese medicine extraction, and specific preparation method is：By each Chinese medicine with room temperature water logging
Bubble, Chinese medicine impregnate 30min, and medicinal powder impregnates 10min, and 10min first is decocted in Radix Notoginseng big fire, then are included in the decoction of other drugs small fire
10min extracts effective water-soluble composition.
When in use, each component is sufficiently mixed for the composition, the 1/100- of total amount after then taking above-mentioned composition to prepare
1/50 is applied with.Or by above-mentioned composition be carried on application on be prepared into application product be applied with.
Embodiment 7：（Control group）
Use current mainstream therapy：Oral vitamin B2 preparations.
It takes combinations of the above object or is applied with products application and be applied with use in the patient with angular stomatitis.
Specifically, choosing patient 42 people of the morbidity within 3 days, 22 people of patient to fall ill more than 3 days amounts to 64 people.It will
Tetra- kinds of formulas of ABCDE, are randomly assigned to 64 patients, and wherein ABCDEF formulas group distributes to 9 patients, wherein falling ill 3 days
Within 6 people of person, more than 3 days 3 people of person；Control group totally 10 people, wherein 6 people of person in 3 days, more than 3 days 4 people of person.It is disappeared with pain, mouth
Angle opening and closing are limited to disappear and has no apparent slight crack and do not fully recover standard.The time required to observing and recording patient's recovery from illness, if occurring more than one week
It is not cured, then it is invalid to be considered as.Since funds and time are limited, this experiment fails to recruit more participants, after also failing to implementation
Continuous 3 months, 6 months, follow-up in 12 months, record participates in patient in 1 year and recurrence whether occurs, real to belong to sorry, but only
From the point of view of current test result, also there is good reference value.
By observation in one week, there is following result：
| Healing number | First day | Second day | Third day | 4th day | 5th day | 6th day | 7th day | It is not cured |
| It is formulated A | 1 | 2 | 3 | 1（1） | 2（2） | - | - | - |
| It is formulated B | 1 | 2 | 4（1） | 2（2） | - | - | - | - |
| It is formulated C | 2 | 3（1） | 3（1） | 1（1） | - | - | - | - |
| It is formulated D | 0 | 1 | 2 | 3（1） | 3（2） | - | - | - |
| It is formulated E | 1 | 2 | 3（2） | 2（1） | 1 | - | - | - |
| It is formulated F | 2 | 3（1） | 2（1） | 2（1） | - | - | - | - |
| Control group | 0 | 0 | 0 | 1 | 2 | 4（2） | 2（1） | 1（1） |
Note：（）Patient of the middle number for morbidity more than 3 days.
There is following discovery by analyzing upper table：（1）In this experiment, the trouble that Vitamin B2 preparation is oral is used in control group
Person fails to fully recover in 3 days, most the fast course for the treatment of 4 days, accounts for the 10% of control group, and has 1 in vain, also accounts for 10%；（2）B, C, F are formulated
Group patient cures within 4 days, wherein 3 days cure rates of formula B groups are 78%, 3 days cure rates of formula C groups are 89%, are formulated F's
Cure rate is 78% within 3 days.
Conclusion：（1）The drug of the present invention has a clear superiority compared to control group, can complete to control in five days substantially
It treats, will not be longer by the delay for the treatment of time limit, to the physiology for reducing patient and psychological pain.（2）It is formulated C groups a small amount of three
Seven application plays extraordinary curative effect for the patient to fall ill more than 3 days.
But the influence factor being directed to is more, temporarily can't comprehensive representation this drug detailed effect.
Claims (10)
1. a kind of composition for treating angular stomatitis, which is characterized in that including Chinese medicine and Western medicine, Chinese medicine includes the powder of radix scutellariae and Fructus Forsythiae
Agent or extracting solution；Western medicine includes VB2Pulvis or equivalent pulvis prepare solution.
2. a kind of composition for treating angular stomatitis according to claim 1, which is characterized in that the radix scutellariae 5-15g, Fructus Forsythiae
5-15g。
3. a kind of composition for treating angular stomatitis according to claim 1, which is characterized in that the VB2For 6.25-
18.75mg。
4. a kind of composition for treating angular stomatitis according to claim 1 or 2 or 3, which is characterized in that the Chinese medicine also wraps
Include the pulvis or extracting solution of peppermint and/or Radix Notoginseng.
5. a kind of composition for treating angular stomatitis according to claim 4, which is characterized in that the Radix Notoginseng is 0.5-
3.5g, peppermint 2-8g.
6. a kind of composition for treating angular stomatitis according to claim 1 or 2 or 3, which is characterized in that the Western medicine also wraps
Include VC, VB1、VB3And VB5At least one of, wherein when more than a kind of, each component is pulvis or is that equivalent pulvis is matched
It is solution that the solution or constituent part of system, which are pulvis constituent part,.
7. a kind of composition for treating angular stomatitis according to claim 6, which is characterized in that described VC, VB1、VB3And VB5
Amount ranges be 6.25-18.75mg.
8. a kind of composition for treating angular stomatitis according to claim 4, which is characterized in that the preparation side of the extracting solution
Method is：Each Chinese medicine is impregnated with normal-temperature water, Chinese medicine impregnates 30min, and medicinal powder impregnates 10min, when having Radix Notoginseng, first by Radix Notoginseng
10min is decocted in big fire, then is included in other drugs small fire and is decocted 10min, and effective water-soluble composition is extracted.
9. a kind of composition for treating angular stomatitis according to claim 6, which is characterized in that further include physiological saline, it is raw
The addition of reason brine makes the concentration range of each western medicine component be 3-60mg/mL.
10. a kind of product using the composition described in any of the above-described claim, which is characterized in that the product is specific
For：The composition is carried in application and is prepared.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810244311.0A CN108310063A (en) | 2018-03-23 | 2018-03-23 | A kind of composition and products thereof for treating angular stomatitis |
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101357154A (en) * | 2008-07-31 | 2009-02-04 | 南方李锦记有限公司 | Chinese herbal medicine composition with bacteriostasis, anti-inflammation hemostasia effect |
| KR20120074703A (en) * | 2010-12-28 | 2012-07-06 | 재단법인 대구테크노파크 | Composition for oral care |
| CN103191039A (en) * | 2013-04-10 | 2013-07-10 | 江苏华生安颐生物科技有限公司 | Mouthwash as well as preparation method and application thereof |
| CN106063793A (en) * | 2015-04-23 | 2016-11-02 | 富力 | The application in preparation treatment antibacterial infection medicine of phillyrin, its derivant, the phillyrin/phillygenol compositions |
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- 2018-03-23 CN CN201810244311.0A patent/CN108310063A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101357154A (en) * | 2008-07-31 | 2009-02-04 | 南方李锦记有限公司 | Chinese herbal medicine composition with bacteriostasis, anti-inflammation hemostasia effect |
| KR20120074703A (en) * | 2010-12-28 | 2012-07-06 | 재단법인 대구테크노파크 | Composition for oral care |
| CN103191039A (en) * | 2013-04-10 | 2013-07-10 | 江苏华生安颐生物科技有限公司 | Mouthwash as well as preparation method and application thereof |
| CN106063793A (en) * | 2015-04-23 | 2016-11-02 | 富力 | The application in preparation treatment antibacterial infection medicine of phillyrin, its derivant, the phillyrin/phillygenol compositions |
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| Title |
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| 刘巧: "《中西医结合皮肤病治疗学》", 31 January 2014, 人民军医出版社 * |
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Application publication date: 20180724 |