CN108653509A - Resolving sputum Chinese medicine composition and its preparation method and application - Google Patents
Resolving sputum Chinese medicine composition and its preparation method and application Download PDFInfo
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- CN108653509A CN108653509A CN201810618940.5A CN201810618940A CN108653509A CN 108653509 A CN108653509 A CN 108653509A CN 201810618940 A CN201810618940 A CN 201810618940A CN 108653509 A CN108653509 A CN 108653509A
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Abstract
The present invention provides a kind of resolving sputum Chinese medicine composition, the resolving sputum Chinese medicine composition includes the raw material of following weight parts：The root bark of white mulberry 2 12, semen brassicae 13, Schisandra chinensis 13, perilla seed 2 12, lepidium seed 2 12, the tuber of pinellia 13, aster 2 12, Exocarpium Citri Rubrum 13, campanulaceae 13.Resolving sputum Chinese medicine composition of the present invention reaches the effect of resolving sputum decorporation phlegm, alleviate abundant expectoration caused by acute and chronic respiratory disease, the symptoms such as cough, asthma are suppressed, had difficulty in breathing, further correct the phlegm-dampness constitution of chronic respiratory disease, progression of disease is blocked or delayed, achievees the purpose that clinical rehabilitation.It can be used for treating the diseases such as chronic pharyngitis, chronic bronchitis, bronchial asthma, Chronic Obstructive Pulmonary Disease, interstitial pneumonia, pulmonary interstitial fibrosis, and significant in efficacy, be free of chemical synthesis substance, target user is extensive.
Description
Technical field
The present invention relates to the field of Chinese medicines, more particularly to a kind of resolving sputum Chinese medicine composition.Meanwhile the invention further relates to a kind ofization
The preparation method and purposes of phlegm Chinese medicine composition.
Background technology
In recent years, development in science and technology is swift and violent, and air pollution aggravates, and great change, respiratory disease also occur for dietary structure
Not only fails to reduce, there is increase trend instead.
First, the Mucociliary system of respiratory tract has powerful defense function, by secreting, sticking, wrap up, transport
Link excretes the harmful substances such as the pathogenic microorganism for sucking respiratory tract, if the system exception, causes ciliary movement fast
Rate and mucus clearance rate are remarkably decreased, and airway mucus siltation occur, and sputum cannot exclude, and lead to bacteria planting, to make gas
Road infection risk increases, airway inflammation recurrent exerbation, and the delay for exacerbating disease is refractory.Furthermore there is phlegm in lung, influence whether lung
Middle oxygen is to the transhipment of capillary, and the long-term abundant expectoration of Patients with Chronic Obstructive Pulmonary Disease, cough, asthma suppress, i.e. lung of having difficulty in breathing
Inside there is the clear proof of phlegm, after treatment, the gurgling weith sputum sound of end-tidal cannot dispel a part of patient, more prove depositing for intrapulmonary product phlegm
.
However, doctor trained in Western medicine is seriously on the low side for the research of chronic respiratory disease and medicament selection, doctor trained in Western medicine lacks at this stage
The drug of the elimination respiratory system immune inflammation of good effect and Small side effects, and the effect of Apophlegmatisant of doctor trained in Western medicine, is undesirable.
Moreover, in existing, western drug be difficult to dispel intrapulmonary product phlegm, modern medicine compares attention to expansion air flue, curative effect of medication nor
Often reliable, still, the air flue after drug withdrawal can restore to the original state, and expansion air flue is interim control symptom, dispel intrapulmonary product phlegm and be only
The key of disease recovery from illness.In conclusion the phlegm in respiratory disease is applied in the overall process of disease always, it is that influence disease is anti-
The most important factor of work, continuing advances, prognosis mala is recurred, however apophlegmatisant causes enough the remote effect of disease not yet
Attention.
The Chinese patent drug for treating such disease currently on the market includes that Nian Ci Um CHUANBEI PIPA GAOs, cough speed stop syrup, compound
Tracheitis piece, lung-clearing anti-inflammatory ball, tonifying lung piece, two female relieving coughing balls, lung power cough, the yellow cough-relieving of Soviet Union etc..CN107648569A discloses one
The kind relieving cough and reducing sputum tablet of Chinese medicine, is prepared by the traditional Chinese medicinal components of following parts by weight：20-40 parts of Siraitia grosvenorii, 10-25 parts of cassia twig,
3-15 parts of seaweed, 2-10 parts of common nightblooming cereus, 10-30 parts of Chinese ephedra, 3-10 parts of eupatorium, 10-20 parts of campanulaceae, 2-15 parts of licorice etc.；Patent
CN102485357B discloses a kind of Chinese medicine composition of facilitaing lung sending down abnormally ascending clearing heat and eliminating phlegm, and active constituent is by following parts by weight
Raw material is made：0.34 part of menthol, 45 parts of fritillary bulb, 45 parts of campanulaceae, 45 parts of rhizoma pinellinae praeparata, 300 parts of loguat leaf.
By analyzing said medicine it is found that it is according to the treatment policy of " lung preferring moisture to dryness, rules for the treatment of nourishing yin to moisten dryness ", Fang Xuansha
The cool lubricant nature drug such as ginseng, Radix Ophiopogonis, stem of noble dendrobium radix polygonati officinalis, campanulaceae, fritillaria thunbergii, loguat leaf, the tuber of stemona, schizonepeta, dried orange peel, Radix Glycyrrhizae.However, such
Airway hyper-reaction caused by phlegm-dampness constitution of the disease mainly by patient, and mucus hypersecretion state, absolutely not dry-heat impairing lung.And it selects
Though it is beneficial absolutely not to the phlegm-dampness constitution of chronic respiratory disease patients with cool lubricant nature drug energy temporary relief symptom, therefore,
It is difficult to block or delay progression of disease.Wherein, some Chinese Patent Medicines contain Chinese ephedra or pappy shell, and Chinese ephedra or the simple cough-relieving of pappy shell are
It is main, when symptom is heavier can brief application, if taking for a long time, possible symptom can mitigate, but to blocking or progression of disease being delayed to fear nothing
Benefit.
Invention content
In view of this, the present invention is directed to propose a kind of resolving sputum Chinese medicine composition significant in efficacy, to reach resolving sputum decorporation phlegm
The effect of, patients in remission further corrects the phlegm-dampness constitution of chronic respiratory disease, blocks or delay progression of disease,
Achieve the purpose that clinical rehabilitation.
In order to achieve the above objectives, the technical proposal of the invention is realized in this way：
A kind of resolving sputum Chinese medicine composition, in parts by weight, the resolving sputum Chinese medicine composition include following raw materials：Sang Bai
Skin 2-12, semen brassicae 1-3, Schisandra chinensis 1-3, perilla seed 2-12, lepidium seed 2-12, tuber of pinellia 1-3, aster 2-12, Exocarpium Citri Rubrum 1-3, tangerine
Obstruct 1-3.
In resolving sputum Chinese medicine composition of the present invention, the effect of each ingredient, is as follows：
Semen brassicae：Pungent-warm, warming lung and reducing phlegm, activating collaterals and eliminating stagnation, outstanding kind cold removing phlegm and the outer phlegm of flesh side film, treat phlegm of trembling with fear stop up lung it
Cough and asthma is uncomfortable in chest, is the best choosing dispelled long-pending phlegm, be not easy the chronic phlegm brought up, and right this product has stimulation to skin and mucous membrane, measures big wound
Stomach answers middle disease i.e. only；The parts by weight of semen brassicae of the present invention are 1-3 parts.
Schisandra chinensis：There is the sweet temperature of acid the effect of convergence lung qi, relieving coughing Dingchuan, cough-relieving apophlegmatic to be used for cough and phlegm, can delay
The violent cough and asthma of solution has benifit more for chronic cough abundant expectoration；The parts by weight of Schisandra chinensis of the present invention are 1-3 parts.
Perilla seed：Pungent-warm, sending down abnormally ascending dissolving phlegm, expectorant cough suppressant and anti-asthmatic relax bowel, and are used for all cards of cough and phlegm, and matter is moistened and slided
Profit helps promote phlegm discharge, and appropriate semen brassicae of arranging in pairs or groups uses, better by phlegm；The parts by weight of perilla seed of the present invention are 2-12
Part.
Lepidium seed：Arduous cold, dispelling phlegm to stop asthma, inducing diuresis for removing edema belong to purging the lung of pathogenic fire superfine product, and resolving sputum saliva, sharp wet non-this of water do not belong to, eliminates
Product phlegm, chronic phlegm best results；The parts by weight of lepidium seed of the present invention are 2-12 parts.
The tuber of pinellia：Pungent-warm has the effect of cough-relieving, eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass, for damp phlegm, cold-phlegm syndrome；
For eliminating dampness and eliminating phlegm key medicine, it is suitable for all cards of internal organs damp phlegm especially；The parts by weight of the tuber of pinellia of the present invention are 2-12 parts.
Aster：Pungent sweetness and bitterness tepor, preventing phlegm from forming and stopping coughing bring up phlegm when one coughs for a variety of.
The root bark of white mulberry：Gan Han, clearing lung, relieving asthma, inducing diuresis for removing edema, be purging the lung of pathogenic fire key medicine, phlegm wet, that is, water, herein Li Shui help resolving sputum, take
It is rushed down, the work(of profit can be replaced without medicine；The root bark of white mulberry matches with lepidium seed, the effect of purging the lung of pathogenic fire can be played, relieving asthma, subside a swelling, the root bark of white mulberry
Lepidium seed purging the lung of pathogenic fire gas can further be promoted and draw phlegm water；The parts by weight of the root bark of white mulberry of the present invention are 2-12 parts.
Exocarpium Citri Rubrum：There is arduous temperature the effect of preventing phlegm from forming and stopping coughing, eliminating dampness and eliminating phlegm, regulating the flow of QI to ease the stomach to cough for damp phlegm, cold productive cough, especially
It is suitable for being often accompanied by the chronic cough and asthma patient of gastral cavilty turgor；The parts by weight of Exocarpium Citri Rubrum of the present invention are 1-3 parts.
Campanulaceae：Toil is slightly cold, and has the effect of facilitaing lung, relieving sore-throat, eliminating the phlegm, cough-relieving, apocenosis, is used for the card of coughing with a lot of sputum, this
The product of product category facilitaing lung, throat arrange lung purulence, tool resolving sputum, decorporation phlegm power；The parts by weight of campanulaceae of the present invention are 1-3 parts.
It is under the guidance of traditional Chinese medicine basic theory, and using ancient Chinese medicine doctor experience records as clue, through facing for many years to take a broad view of full side
Gained is verified and optimized to bed practice and autoscopia repeatedly.In the present invention, based on the tuber of pinellia and two medicine phases of Exocarpium Citri Rubrum are matched, main eliminating dampness
Resolving sputum；Clinically there is phlegm in lung, it is difficult to it is only dispelled by resolving sputum, therefore semen brassicae, perilla seed, lepidium seed is added in the present invention,
Three medicine phases, which are matched, to dispel intrapulmonary product phlegm strongly by phlegm；The root bark of white mulberry, lepidium seed are added in the present invention, cough is alleviated in main purging the lung of pathogenic fire resolving sputum
It the symptoms such as coughs, pant；Campanulaceae, Schisandra chinensis, the tuber of pinellia, aster, perilla seed match in the present invention, and master is relieving cough and reducing sputum；Semen brassicae, the five tastes
Son, perilla seed, lepidium seed all have lubricating action, and four medicine phases can pass through with the effect of can not only reaching preventing phlegm from forming and stopping coughing
Lubrication achievees the effect that decorporation phlegm so that expectoration is easy.
Therefore, on the one hand, take the present invention resolving sputum Chinese medicine composition after first symptoms change be phlegm tail off, appearance of coughing up phlegm
Easily, mechanism may reduce the mucus hypersecretion of air flue for it, and the production of phlegm can be reduced or be absorbed, meanwhile, respiratory tract sticks
The air flue fibre swing of liquid-cilium system takes a turn for the better so that the system function is restored, and the chance of the infection of the upper respiratory tract can be apparent
It reduces, is equivalent to the immunity for improving body, to which repeated infection induces chronic respiratory disease or aggravates important
Factor can slow down significantly；On the other hand, resolving sputum Chinese medicine composition multiselect warm nature drug of the invention, takes one month or time
The phlegm-dampness constitution of patient can be corrected after remote, and then blocks or delays progression of disease, achieve the purpose that clinical rehabilitation.To sum up institute
It states, each component and its content of resolving sputum composition of the present invention are reasonable, mutual cooperation and supplement between each component.
Further, in parts by weight, the resolving sputum Chinese medicine composition includes following raw materials：Root bark of white mulberry 2-6, sinapsis alba
Sub- 1-3, Schisandra chinensis 1-3, perilla seed 2-6, lepidium seed 2-6, tuber of pinellia 1-3, aster 2-6, Exocarpium Citri Rubrum 1-3, campanulaceae 1-3.
Further, in parts by weight, the resolving sputum Chinese medicine composition includes following raw materials：The root bark of white mulberry 2, semen brassicae
1, Schisandra chinensis 1, perilla seed 2, lepidium seed 2, the tuber of pinellia 1, aster 2, Exocarpium Citri Rubrum 1, campanulaceae 1.
Further, in parts by weight, the resolving sputum Chinese medicine composition includes following raw materials：It is root bark of white mulberry 6-12, white
Mustard seed 1-3, Schisandra chinensis 1-3, perilla seed 6-12, lepidium seed 6-12, tuber of pinellia 1-3, aster 6-12, Exocarpium Citri Rubrum 1-3, campanulaceae 1-3.For
The patient being in a bad way, can dosage using the root bark of white mulberry, perilla seed, lepidium seed, aster.
Further, the resolving sputum Chinese medicine composition further includes following raw materials：The dried immature fruit of citron orange of 1-3 parts by weight, with reduction of patient
It has a stomach upset.
Modern medicine proves a part of patients with chronic pharyngitis simultaneously also with chronic gastritis, and therefore, the present invention, which designs, to be added
Patient's throat discomfort sense caused by gastritis can be effectively relieved in the dried immature fruit of citron orange of 1-3 parts by weight；Meanwhile the dried immature fruit of citron orange has regulating qi-flowing for eliminating phlegm
The effect of, the resolving sputum effect of the present invention can be further enhanced.
Another object of the present invention is to propose a kind of preparation method of resolving sputum Chinese medicine composition, to prepare in above-mentioned resolving sputum
Drug composition.
In order to achieve the above objectives, the technical proposal of the invention is realized in this way：
A kind of preparation method of resolving sputum Chinese medicine composition, includes the following steps：
A, each raw material is weighed according to weight part ratio；
B, by the raw material in step a through one or more methods in crushing, decoction, immersion be prepared powder,
After solution or paste, oral preparation is prepared as using conventional means.
Further, the oral preparation is any one of capsule, pill, granule, oral solution, decoction or paste.
Another object of the present invention is to propose a kind of purposes of resolving sputum Chinese medicine composition.
In order to achieve the above objectives, the technical proposal of the invention is realized in this way：
A kind of purposes of resolving sputum Chinese medicine composition, including the resolving sputum Chinese medicine composition are preparing treatment chronic pharyngitis, slow
In property bronchitis, Chronic Obstructive Pulmonary Disease, interstitial pneumonia, the drug of pulmonary interstitial fibrosis, health food and food
Using.
Compared with the existing technology, the present invention has the advantage that：
(1) resolving sputum Chinese medicine composition of the present invention has the effect of resolving sputum decorporation phlegm, can alleviate acute and chronic breathing system
Abundant expectoration, cough, asthma caused by system disease such as suppress, have difficulty in breathings at the symptoms, can clinical treatment chronic pharyngitis, chronic bronchitis, slowly
Property the diseases such as obstructive disease of lung, interstitial pneumonia, pulmonary interstitial fibrosis, and it is significant in efficacy, be better than Chinese medicine in the prior art
Composition.
(2) resolving sputum Chinese medicine composition of the present invention passes through the function of recovery respiratory tract mucus-cilium system, upper breathing
The chance of road infection can significantly reduce, and be equivalent to the immunity for improving body, to which repeated infection is to chronic respiratory system disease
Disease induces or can slow down significantly an important factor for exacerbation.
(3) intrapulmonary accumulates dispelling for phlegm, can improve oxygen exchange between alveolar and capillary, improve the oxygen carrying energy of blood
Power will necessarily alleviate symptom when respiratory disease severe, such as cough, cough up phlegm, breathing heavily and suppress, have difficulty in breathing.
(4) phlegm-dampness constitution for correcting chronic respiratory disease, blocks or delays progression of disease, further reach clinical health
Multiple purpose.
(5) resolving sputum Chinese medicine composition of the present invention is free of chemical synthesis substance, and target user is extensive, is particularly suitable for
The long-term middle-aged and the old of chronic cough or asthma all the year round.
(6) resolving sputum Chinese medicine composition of the present invention can be made into capsule, pill, granule, oral solution, decoction or cream
Agent, so that different groups select to use.
Specific implementation mode
It should be noted that in the absence of conflict, the feature in embodiment and embodiment in the present invention can phase
Mutually combination.
In the present invention, if not refering in particular to, all parts are mass unit.Method in the following example, if not it refers in particular to,
It is the conventional method of this field.
Below in conjunction with embodiment, the present invention will be described in detail.
Embodiment 1
The present embodiment is related to one group of resolving sputum Chinese medicine composition and preparation method thereof.
Embodiment 1.1
A, each following raw materials are weighed according to weight part ratio：Root bark of white mulberry 60g, semen brassicae 15g, Schisandra chinensis 15g, perilla seed
60g, lepidium seed 60g, tuber of pinellia 15g, aster 60g, Exocarpium Citri Rubrum 15g, campanulaceae 15g；
B, 7.5g Schisandra chinensis is taken, the Schisandra chinensis is carried out to beat powder, the Fructus Schisandrae Chinensis powder of 100 mesh is obtained, as matrix；
C, it is decocted to except the water that 6 times of raw material gross weight is added in extramatrical remaining material, matrix is then added and endures
It is made after drying after cream and crushes, obtain the resolving sputum Chinese medicine composition powder of 90 mesh；
D, resolving sputum Chinese medicine composition powder made from step c is packed into No. 0 capsule, every 0.5g, disinfection sealing.
The carrier that the present embodiment is chosen is capsule, but not limited to this.Carrier can't be to resolving sputum Chinese medicine composition of the present invention
The effect of generate substantial influence, can be selected from any one of capsule, pill, granule, oral solution, decoction or paste, can root
It is selected according to actual needs.
Embodiment 1.2
A, each following raw materials are weighed according to weight part ratio：Root bark of white mulberry 30g, semen brassicae 15g, Schisandra chinensis 15g, perilla seed
30g, lepidium seed 30g, tuber of pinellia 15g, aster 30g, Exocarpium Citri Rubrum 15g, campanulaceae 15g；
B, the water that 6 times of raw material gross weight is added into raw material is decocted, after appropriate amount of auxiliary materials granulation, drying is then added,
10g/ packets are distributed into get granule.
Embodiment 1.3
A, each following raw materials are weighed according to weight part ratio：Root bark of white mulberry 20g, semen brassicae 10g, Schisandra chinensis 10g, perilla seed
20g, lepidium seed 20g, tuber of pinellia 10g, aster 20g, Exocarpium Citri Rubrum 10g, campanulaceae 10g；
B, 5g Schisandra chinensis is taken, the Schisandra chinensis is carried out to beat powder, the Fructus Schisandrae Chinensis powder of 80 mesh is obtained, as matrix；
C, it is decocted to except the water that 6 times of raw material gross weight is added in extramatrical remaining material, matrix is then added and endures
It is made after drying after cream and crushes, obtain the resolving sputum Chinese medicine composition powder of 80 mesh；
D, resolving sputum Chinese medicine composition powder made from step c is packed into No. 0 capsule, every 0.5g, disinfection sealing.
Embodiment 1.4
A, each following raw materials are weighed according to weight part ratio：Root bark of white mulberry 10g, semen brassicae 5g, Schisandra chinensis 5g, perilla seed 10g,
Lepidium seed 10g, tuber of pinellia 5g, aster 10g, Exocarpium Citri Rubrum 5g, campanulaceae 5g；
B, the water that 7 times of raw material gross weight is added into raw material is decocted, and is filtered, and is packed as 100ml/ bottles to get oral
Liquid.
Embodiment 1.5
A, each following raw materials are weighed according to weight part ratio：Root bark of white mulberry 40g, semen brassicae 15g, Schisandra chinensis 15g, perilla seed
40g, lepidium seed 40g, tuber of pinellia 15g, aster 40g, Exocarpium Citri Rubrum 15g, campanulaceae 15g；Dried immature fruit of citron orange 10g；
B, the water that 8 times of raw material gross weight is added into raw material is decocted, and proper honey is then added and is brewed into cream, obtains
40ml paste is packed as 10ml/ packets to get paste.
Embodiment 1.6
A, each following raw materials are weighed according to weight part ratio：Root bark of white mulberry 50g, semen brassicae 15g, Schisandra chinensis 15g, perilla seed
50g, lepidium seed 50g, tuber of pinellia 15g, aster 50g, Exocarpium Citri Rubrum 15g, campanulaceae 15g；
B, the water that 8 times of raw material gross weight is added into raw material is decocted, and is filtered, is obtained 360ml paste, be packed as
180ml/ packets are to get decoction.
Embodiment 2
The present embodiment is related to the clinical effectiveness experiment of resolving sputum Chinese medicine composition of the present invention.
It is verified through hundreds of patient clinicals, the composition in resolving sputum Chinese medicine composition more than ten years of clinical application of the present invention
Can resolving sputum and decorporation phlegm, alleviate the symptoms such as the turbid obstruction of phlegm, dys-expectoration, also there is the ventilatory for improving lung and raising blood
The effect of oxygen saturation, can alleviate abundant expectoration caused by acute and chronic respiratory disease, the diseases such as cough, asthma are suppressed, had difficulty in breathing
Shape, can clinical treatment chronic pharyngitis, chronic bronchitis, Chronic Obstructive Pulmonary Disease, interstitial pneumonia, pulmonary interstitial fibrosis etc.
Disease all has good therapeutic effect, has extensive clinical application.It is the resolving sputum Chinese medicine composition clinical application below
Clinical effectiveness is tested.
Embodiment 2.1
The present embodiment is related to the Clinical efficacy of 1000 general patients, diagnostic criteria according to doctor trained in Western medicine clinical practice,
Middle patients with chronic pharyngitis 200, chronic bronchitis patient 400, Patients with Chronic Obstructive Pulmonary Disease 200, chromic fibrous lung
Scorching patient 50, Bronchial Asthmas 50, pulmonary interstitial fibrosis patient 100.The range of age 5-80 Sui, with 50 years old or more
In the majority, patient is divided into 5 groups by the course of disease 1 month to 30 years：Wherein, control group is that above-mentioned 6 type patient respectively randomly selects 20
Example, remaining patient are treatment group：A groups are chronic pharyngitis group；B groups are chronic bronchitis group；C groups are Chronic Obstructive Pulmonary Disease
Group；D groups are other groups, including remaining patient.No difference of science of statistics between 5 groups of patients, all non-control group subjects are observing
Drug that is related to this disease or may influencing clinical efficacy and adverse reaction evaluation is not used in period, and 5 groups of patients are receiving this
Before secondary treatment, Western medicine or Chinese medicine was once used to treat, but effect is undesirable.
Case inclusion criteria：(1) clinically to cough, cough up phlegm as cardinal symptom or be suppressed with asthma, be had difficulty in breathing；(2) it accords with
Close doctor trained in Western medicine clinical practice relevant disease diagnostic criteria；(3) other hearts, lung disease (such as pulmonary tuberculosis, lung cancer, heart disease) except.(4)
All case medication times are not less than 3 weeks.
Therapeutic scheme：(1) treatment group patient is all made of the Chinese medicinal composition capsules preparation of resolving sputum embodiment 1 of the present invention.It controls
Treatment group a, b is taken medicine 2 times daily, 6 tablets each time；Treatment group c, d take medicine 3 times daily, 10 tablets each time；Other groups take the present embodiment 4
Chinese medicinal composition capsules preparation, daily medication 3 times, 10 tablets each time；Control group takes eucalyptus lemon pinane enteric soft capsules orally, every time
0.3g, 3 times a day.(2) 3 weeks as a treatment course.(3) the follow-up date is 3 months, 6 months, 1 year, 2 years, 3 years, individual severe patients
It can be 6 years.
Observation index：(1) it coughs, cough up phlegm, breathing heavily and the clinical symptoms such as suppress, have difficulty in breathing；(2) wheezing sound of end-tidal；(3) feel
Emit a year attack times；(4) pulmonary function detection.It is as shown in table 1 to observe result summary sheet.
Table 1 observes result summary sheet
| Treatment group | Control group | |
| Observation index (1) is efficient | 98% | 80% |
| Observation index (2) is efficient | 95% | 60% |
| Observation index (3) is efficient | 90% | 62% |
| Observation index (4) is efficient | 92% | 66% |
Table 1 shows the observation result summary sheet of 1000 general patients, from the data in the table：For observation index
(1), treatment group's effective percentage 98%, control group effective percentage 80%；2, for observation index (2), treatment group's effective percentage 95%, control
Group effective percentage 60%；3, for observation index (3), treatment group's effective percentage 90%, control group effective percentage 62%；4, observation is referred to
It marks (4), treatment group's effective percentage 92%, control group effective percentage 66%.It follows that the resolving sputum Chinese medicine composition of the present invention is for controlling
It treats that acute and chronic respiratory disease is significant, is the reliable drug for blocking or delaying progression of disease.In addition, by above-mentioned observation
As a result known to：1. after dosage increases, every observation index improves apparent；2. the disease treatment time is proportionate with course of disease time,
That is, sick time longer treatment time accordingly extends；3. in each observation index, the improvement of end-tidal wheezing sound is obviously excellent
In other Apophlegmatisants.
Embodiment 2.2
The present embodiment is related to the part model case of the resolving sputum Chinese medicine composition clinical application.
Case 1：Mrs Guo, 45 years old, onset symptoms cough, abundant expectoration, shortness of breath uncomfortable in chest, expiratory dyspnea were controlled in clinic by flu
One week is treated without alleviation, certain Grade A hospital is entered, is diagnosed as interstitial pneumonia, subsequently input antibiotic, hormone, apophlegmatisant, branch gas
The drugs such as enlargement of pipe medicine, treatment 21 days, the state of an illness still persistently aggravates, and is transferred to certain Grade A hospital again, is infused 8 days, and patient's asthma is suppressed tight
Weight, expiratory dyspnea are apparent, can not be movable, and change the place of examination this doctor, advises hormone slowly to remove and subtracts, and remaining Western medicine full cut-off takes implementation of the present invention
The resolving sputum Chinese medicine composition decoction of example 1.6, one dose per day are divided 2-3 times and are taken, and symptom is relieved after 1 month, continuously takes 4
More than month, all symptom complete incidence graphs, walking such as ordinary person, 4 years no relapse of follow-up.
Case 2：Mr. Zhang, man, 65 years old, coughs, coughed up phlegm for more than 30 years, aggravates to suppress, more than the moon of having difficulty in breathing with asthma, is cured in certain county
More than the moon, symptom slightly mitigates institute's hospitalization, but can not complete incidence graph, patient respiratory is difficult apparent when going to a doctor, and walks on their own one
Secondary no more than 50 meters, double lower limb oedema.Hospital diagnosis is：Chronic bronchitis, Chronic Obstructive Pulmonary Disease, pulmonary heart
Disease, cardiac insufficiency.Resolving sputum Chinese medicine composition decoction of the present invention is taken more than the moon, coughs, cough up phlegm, breathing heavily and suppress, have difficulty in breathing apparent delay
Solution, after be changed to take 1.5 resolving sputum Traditional Chinese medicine composition paste of the embodiment of the present invention, be changed to take the embodiment of the present invention 1.1 after 3 months
Resolving sputum Chinese medicinal composition capsules, 10 tablets each time, 3 times a day, all symptom most of the relief, even expectoration is few, can carry out general family
Business labour, is now still interrupted and takes, follow-up has no that apparent exacerbation, times of common cold also significantly reduce for 1 year.
Case 3：Mrs Li 52 years old, has phlegm in larynx, coughs, coughed up phlegm for more than ten years, and every coherence check is no abnormal,
Once in taking, western drug is without positive effect, tentative diagnosis：Chronic pharyngitis, chronic bronchitis give the embodiment of the present invention 1.3
Resolving sputum Chinese medicinal composition capsules, 10 tablets each time, 3 times a day, symptom mitigates after a week, symptom most of the relief after three months, after
Feel have phlegm that can take this medicine 6-10, follow-up 5 years in larynx, symptom has no that exacerbation, flu breaking-out significantly reduce, can assert and face
Bed is cured.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
With within principle, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention god.
Claims (8)
1. a kind of resolving sputum Chinese medicine composition, it is characterised in that：In parts by weight, the resolving sputum Chinese medicine composition includes following
Raw material：Root bark of white mulberry 2-12, semen brassicae 1-3, Schisandra chinensis 1-3, perilla seed 2-12, lepidium seed 2-12, tuber of pinellia 1-3, aster 2-12, tangerine
Red 1-3, campanulaceae 1-3.
2. resolving sputum Chinese medicine composition according to claim 1, it is characterised in that：In parts by weight, in the resolving sputum
Drug composition includes following raw materials：Root bark of white mulberry 2-6, semen brassicae 1-3, Schisandra chinensis 1-3, perilla seed 2-6, lepidium seed 2-6, tuber of pinellia 1-
3, aster 2-6, Exocarpium Citri Rubrum 1-3, campanulaceae 1-3.
3. resolving sputum Chinese medicine composition according to claim 2, it is characterised in that：In parts by weight, in the resolving sputum
Drug composition includes following raw materials：The root bark of white mulberry 2, semen brassicae 1, Schisandra chinensis 1, perilla seed 2, lepidium seed 2, the tuber of pinellia 1, aster 2, Exocarpium Citri Rubrum
1, campanulaceae 1.
4. resolving sputum Chinese medicine composition according to claim 1, it is characterised in that：In parts by weight, in the resolving sputum
Drug composition includes following raw materials：Root bark of white mulberry 6-12, semen brassicae 1-3, Schisandra chinensis 1-3, perilla seed 6-12, lepidium seed 6-12, half
Summer 1-3, aster 6-12, Exocarpium Citri Rubrum 1-3, campanulaceae 1-3.
5. the resolving sputum Chinese medicine composition according to any one of claim 1-4, it is characterised in that：The resolving sputum Chinese traditional medicine composition
Object further includes following raw materials：The dried immature fruit of citron orange of 1-3 parts by weight.
6. a kind of preparation method of resolving sputum Chinese medicine composition, it is characterised in that：Prepare the change described in any one of claim 1-5
The method of phlegm Chinese medicine composition includes the following steps：
A, each raw material is weighed according to weight part ratio；
B, powder, solution is prepared through one or more methods in crushing, decoction, immersion in the raw material in step a
Or after paste, oral preparation is prepared as using conventional means.
7. the preparation method of resolving sputum Chinese medicine composition according to claim 6, it is characterised in that：The oral preparation is glue
Any one of capsule, pill, granule, oral solution, decoction or paste.
8. a kind of purposes of resolving sputum Chinese medicine composition, it is characterised in that：Any one of the claim 1-5 resolving sputum Chinese traditional medicine compositions
Object is being prepared between treatment chronic pharyngitis, chronic bronchitis, bronchial asthma, Chronic Obstructive Pulmonary Disease, interstitial pneumonia, lung
Application in the drug of matter fibrosis, health food and food.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN111298011A (en) * | 2020-04-17 | 2020-06-19 | 北京中医药大学 | Traditional Chinese medicine for treating viral pneumonia and eliminating phlegm and stagnation |
| CN114796453A (en) * | 2022-02-25 | 2022-07-29 | 中科梅奥(杭州)生物工程有限公司 | Method for applying BMAP (BMAP) derived peptide to respiratory system cough antiphlogosis |
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