CN108290835B - Alk和srpk的抑制剂和使用方法 - Google Patents

Alk和srpk的抑制剂和使用方法 Download PDF

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Publication number
CN108290835B
CN108290835B CN201680068205.0A CN201680068205A CN108290835B CN 108290835 B CN108290835 B CN 108290835B CN 201680068205 A CN201680068205 A CN 201680068205A CN 108290835 B CN108290835 B CN 108290835B
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compound
alk
alkyl
cancer
formula
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CN108290835A (zh
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J·哈彻
N·S·格雷
崔焕根
P·詹尼
T·张
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Dana Farber Cancer Institute Inc
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Dana Farber Cancer Institute Inc
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    • C07—ORGANIC CHEMISTRY
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    • C07D209/56—Ring systems containing three or more rings
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    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/11—Protein-serine/threonine kinases (2.7.11)
    • C12Y207/11001—Non-specific serine/threonine protein kinase (2.7.11.1), i.e. casein kinase or checkpoint kinase

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  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
CN201680068205.0A 2015-09-23 2016-09-23 Alk和srpk的抑制剂和使用方法 Expired - Fee Related CN108290835B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562222504P 2015-09-23 2015-09-23
US62/222,504 2015-09-23
US201662356066P 2016-06-29 2016-06-29
US62/356,066 2016-06-29
PCT/US2016/053245 WO2017053657A1 (en) 2015-09-23 2016-09-23 Inhibitors of alk and srpk and methods of use

Publications (2)

Publication Number Publication Date
CN108290835A CN108290835A (zh) 2018-07-17
CN108290835B true CN108290835B (zh) 2022-03-08

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US (3) US10508082B2 (https=)
EP (1) EP3353150A4 (https=)
JP (1) JP6797923B2 (https=)
CN (1) CN108290835B (https=)
HK (1) HK1257171A1 (https=)
WO (1) WO2017053657A1 (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017053657A1 (en) * 2015-09-23 2017-03-30 Dana-Farber Cancer Institute, Inc. Inhibitors of alk and srpk and methods of use
US11179412B2 (en) * 2017-12-04 2021-11-23 University of Pittsburgh—of the Commonwealth System of Higher Education Methods of treating conditions involving elevated inflammatory response
JP7054134B2 (ja) * 2017-12-07 2022-04-13 国立大学法人京都大学 ベンゾ［ｂ］カルバゾール化合物及びそれを用いたイメージング
EP4192832A1 (de) * 2020-08-06 2023-06-14 Merck Patent GmbH Materialien für organische elektrolumineszenzvorrichtungen
WO2022076409A1 (en) * 2020-10-06 2022-04-14 Dana-Farber Cancer Institute, Inc. Potent and selective covalent inhibitors of serine-arginine protein kinase (srpk) 1 and srpk2 and uses thereof
CN113135907B (zh) * 2021-04-28 2022-02-22 山东大学 一种提高α-微管蛋白乙酰化水平的化合物及其制备方法与应用
CN115340523B (zh) * 2021-05-12 2023-12-15 盛世泰科生物医药技术(苏州)股份有限公司 一种具有alk抑制活性的化合物及其制备方法和用途

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010143664A1 (ja) * 2009-06-10 2010-12-16 中外製薬株式会社 ４環性化合物
CN102015691A (zh) * 2008-04-29 2011-04-13 诺瓦提斯公司 作为活化素样受体激酶(alk4或alk5)抑制剂的咪唑并吡啶衍生物
CN104177342A (zh) * 2013-05-21 2014-12-03 中国科学院上海药物研究所 杂环基取代的吲哚并萘酮衍生物及其医药用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5006987B2 (ja) * 2010-11-22 2012-08-22 中外製薬株式会社 ４環性化合物を含む医薬
WO2017053657A1 (en) * 2015-09-23 2017-03-30 Dana-Farber Cancer Institute, Inc. Inhibitors of alk and srpk and methods of use

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102015691A (zh) * 2008-04-29 2011-04-13 诺瓦提斯公司 作为活化素样受体激酶(alk4或alk5)抑制剂的咪唑并吡啶衍生物
WO2010143664A1 (ja) * 2009-06-10 2010-12-16 中外製薬株式会社 ４環性化合物
CN104177342A (zh) * 2013-05-21 2014-12-03 中国科学院上海药物研究所 杂环基取代的吲哚并萘酮衍生物及其医药用途

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"CH5424802, a Selective ALK Inhibitor Capable of Blocking the Resistant Gatekeeper Mutant";Hiroshi Sakamoto等;《Cancer Cell》;20110517;第19卷(第5期);第679-690页 *
"Design and synthesis of a highly selective,orally active and potent anaplastic lymphoma kinase inhibitor (CH5424802)";Kazutomo Kinoshita等;《Bioorganic & Medicinal Chemistry》;20111222;第20卷(第3期);第1271-1280页 *
"Targeting SRPK1 to control VEGF-mediated tumour angiogenesis in metastatic melanoma";M V Gammons等;《British Journal of Cancer》;20140710;第111卷;第477-485页 *

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Publication number Publication date
EP3353150A1 (en) 2018-08-01
CN108290835A (zh) 2018-07-17
WO2017053657A1 (en) 2017-03-30
US20180258040A1 (en) 2018-09-13
EP3353150A4 (en) 2019-06-19
HK1257171A1 (zh) 2019-10-18
JP2018531993A (ja) 2018-11-01
US11066363B2 (en) 2021-07-20
US11858897B2 (en) 2024-01-02
US10508082B2 (en) 2019-12-17
US20200223798A1 (en) 2020-07-16
JP6797923B2 (ja) 2020-12-09
US20210340102A1 (en) 2021-11-04

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Inventor after: J. Hatcher

Inventor after: N.S. Grey

Inventor after: Cui Huangen

Inventor after: P. Jenny

Inventor after: T.Zhang

Inventor before: J. Hatcher

Inventor before: N.S. Grey

Inventor before: H.G.Cui

Inventor before: P. Jenny

Inventor before: T.Zhang

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Granted publication date: 20220308