CN108283711A - A kind of instant particles as Chinese medicine and preparation method thereof for treating alcoholic myocardiopathy - Google Patents
A kind of instant particles as Chinese medicine and preparation method thereof for treating alcoholic myocardiopathy Download PDFInfo
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Abstract
The invention discloses a kind of instant particles as Chinese medicine and preparation method thereof for treating alcoholic myocardiopathy, belong to the field of Chinese medicines.The raw material group of effective ingredient of the present invention becomes：Arillus longan, wild rice stem, radix pseudostellariae, gynostemma pentaphylla, jujube, thatch screwpine fruit, buckbean, the seed of Oriental arborvitae, hoveniae semoveniae semen, the tuber of dwarf lilyturf, rhizoma zingiberis, Folium Pleioblasti, Radix Glycyrrhizae, rose rhodobryum herb, radix paeoniae rubra, clear eggplant, Rhizoma Chuanxiong, horseradish grass, dried orange peel, high mountain enchanter's nightshade, bush, grass-leaved sweetflag, Radix Polygalae, styrax.The present invention selects medicinal material to meet a monarch and his subjects left side and is allowed to manage, it suits the remedy to the case for the cause of disease, have nourishing heart invigorating the spleen, boosting qi and nourishing yin, warming meridians and promoting circulation of qi, the promoting flow of qi and blood circulation, promoting blood circulation, resolving sputum dampness removing, removing toxic substances sober up, mental-tranquilization, reducing fever and causing diuresis the effect of, good absorption effect, it is significant in efficacy, it has no toxic side effect and clinical adverse, it is higher to alcoholic myocardiopathy cure rate according to clinical verification.
Description
Technical field
The present invention relates to the field of Chinese medicines more particularly to a kind of instant particles as Chinese medicine for treating alcoholic myocardiopathy and its preparation sides
Method.
Background technology
Alcoholic myocardiopathy, which refers to morbidity and long-term a large amount of Ethanol intake, substantial connection, has typical dilated cardiomyopathy
Blood stream rheology, symptom, seen in sign and iconography, a kind of state of an illness voluntarily can be alleviated or fully recover after abstinence from alcohol cardiac muscle disease
Suffer from.Clinical manifestation is arrhythmia cordis, Heart enlargement, congestive heart failure etc..In recent years, carrying with people's living standard
Height, alcoholic beverage consumption dramatically increase, and alcoholic myocardiopathy incidence shows ascendant trend year by year, seriously affects patient
Quality of life, or even threaten its life security.
The generation of alcoholic myocardiopathy has substantial connection with long-term a large amount of intake alcohol, and the key for the treatment of is abstinence from alcohol.Nothing
Which kind of, by being in a bad way to degree, it is expected to obtain the alleviation of the state of an illness after majority of cases abstinence from alcohol.Drug therapy itself is only then one kind
Makeshift, is not thorough abstinence from alcohol, the treatment of this disease is by fall through.
The key of this disease of western medical treatment is early diagnosis, early stage abstinence from alcohol and symptomatic treatment to continue or reverse disease.It closes
And should lie up when heart failure, into high nutrition, high protein, low salt diet, usable angiotensin converting enzyme inhibitors,
Low dose of digitalis cardiac stimulant is interrupted diuresis, while expanding blood vessel, the improvement of heart function with can abstinence from alcohol relationship it is larger.No matter blood magnesium
Whether reduce, magnesium should all be supplemented for a long time, it, cannot magnesium contains in antimer strictly according to the facts because serum magnesium only accounts for the 1% of internal magnesium total amount
Amount.Since B family vitamin lacks, also should largely supplement.Ethyl alcohol may interfere with the transhipment of myocardial cell membrane calcium ion, calcium ion antagonism
Agent can try out, and have apparent arrhythmia cordis person in early days, can preferred diltiazem or Verapamil.This disease of western medical treatment is mainly basis
Clinical symptoms carry out symptomatic treatment, are unable to wholistic therapy, treatment cycle is long, and therapeutic effect is bad.
From Chinese medicine, the interpretation of the cause, onset and process of an illness of alcoholic myocardiopathy is mainly based on motive virtual loss, blood stasis, damp and hot, phlegm and retained fluid, scorchingly hot
Inside accumulate to mark, the present invention suits the remedy to the case according to the cause of disease, on the basis of patient's complete abstinence from alcohol, passes through oral Chinese medicine of the present invention and rushes
Agent, with reach nourishing heart invigorating the spleen, boosting qi and nourishing yin, warming meridians and promoting circulation of qi, the promoting flow of qi and blood circulation, promoting blood circulation, resolving sputum dampness removing, removing toxic substances sober up, nourishing heart
Calm the nerves, reducing fever and causing diuresis the effect of, good absorption effect is significant in efficacy, has no toxic side effect and clinical adverse, right according to clinical verification
Alcoholic myocardiopathy cure rate is higher.
Invention content
The present invention provides a kind of instant particles as Chinese medicine and preparation method thereof for treating alcoholic myocardiopathy, have nourishing heart invigorating the spleen,
Boosting qi and nourishing yin, warming meridians and promoting circulation of qi, the promoting flow of qi and blood circulation, promoting blood circulation, resolving sputum dampness removing, removing toxic substances sober up, mental-tranquilization, reducing fever and causing diuresis work(
Effect, cures the disease and seeks source treating both manifestation and root cause of disease, fine curative effect is all had to alcoholic myocardiopathy.
To achieve the above object, technical scheme of the present invention is implemented as follows：
The raw material composition and parts by weight of the effective ingredient is made in a kind of instant particles as Chinese medicine for treating alcoholic myocardiopathy
For：
15~35 parts of arillus longan, 15~35 parts of wild rice stem, 15~35 parts of radix pseudostellariae, 15~30 parts of gynostemma pentaphylla,
15~30 parts of jujube, 15~25 parts of thatch screwpine fruit, 15~25 parts of buckbean, 15~25 parts of the seed of Oriental arborvitae,
10~20 parts of hoveniae semoveniae semen, 10~20 parts of the tuber of dwarf lilyturf, 10~20 parts of rhizoma zingiberis, 9~15 parts of Folium Pleioblasti,
9~15 parts of Radix Glycyrrhizae, 9~15 parts of rose rhodobryum herb, 6~12 parts of radix paeoniae rubra, 6~12 parts of clear eggplant,
4~10 parts of Rhizoma Chuanxiong, 4~10 parts of horseradish grass, 4~10 parts of dried orange peel, 3~9 parts of high mountain enchanter's nightshade,
3~9 parts of bush, 2~6 parts of grass-leaved sweetflag, 1~4 part of Radix Polygalae, 1~4 part of styrax.
The raw material that the effective ingredient is made forms and parts by weight are：
20~32 parts of arillus longan, 18~30 parts of wild rice stem, 18~30 parts of radix pseudostellariae, 18~25 parts of gynostemma pentaphylla,
18~25 parts of jujube, 18~22 parts of thatch screwpine fruit, 18~22 parts of buckbean, 18~22 parts of the seed of Oriental arborvitae,
13~18 parts of hoveniae semoveniae semen, 13~18 parts of the tuber of dwarf lilyturf, 12~16 parts of rhizoma zingiberis, 11~14 parts of Folium Pleioblasti,
11~13 parts of Radix Glycyrrhizae, 11~13 parts of rose rhodobryum herb, 8~10 parts of radix paeoniae rubra, 8~10 parts of clear eggplant,
6~9 parts of Rhizoma Chuanxiong, 6~9 parts of horseradish grass, 6~9 parts of dried orange peel, 5~8 parts of high mountain enchanter's nightshade,
5~8 parts of bush, 3~5 parts of grass-leaved sweetflag, 2~4 parts of Radix Polygalae, 1~3 part of styrax.
The raw material that the effective ingredient is made forms and parts by weight are：
28 parts of arillus longan, 26 parts of wild rice stem, 26 parts of radix pseudostellariae, 23 parts of gynostemma pentaphylla,
22 parts of jujube, 20 parts of thatch screwpine fruit, 20 parts of buckbean, 20 parts of the seed of Oriental arborvitae,
16 parts of hoveniae semoveniae semen, 16 parts of the tuber of dwarf lilyturf, 14 parts of rhizoma zingiberis, 13 parts of Folium Pleioblasti,
12 parts of Radix Glycyrrhizae, 12 parts of rose rhodobryum herb, 9 parts of radix paeoniae rubra, 9 parts of clear eggplant,
8 parts of Rhizoma Chuanxiong, horseradish grass 8 parts, 8 parts of dried orange peel, 7 parts of high mountain enchanter's nightshade,
6 parts of bush, 4 parts of grass-leaved sweetflag, 3 parts of Radix Polygalae, 2 parts of styrax.
A kind of preparation method of instant particles as Chinese medicine that treating alcoholic myocardiopathy, comprises the following steps that：
（1）By arillus longan, thatch screwpine fruit, hoveniae semoveniae semen, clean be put into container, be added 4 times amount concentration 80% ethanol solution, leaching
It is spare to obtain filtrate for bubble 1-2 hours, heating and refluxing extraction 3-4 hours, filtering；
（2）By wild rice stem, radix pseudostellariae, gynostemma pentaphylla, jujube, buckbean, the seed of Oriental arborvitae, the tuber of dwarf lilyturf, rhizoma zingiberis, Folium Pleioblasti, rose rhodobryum herb, clear eggplant
Son, horseradish grass, dried orange peel, high mountain enchanter's nightshade, bush, grass-leaved sweetflag are put into after cleaning in container, and the 8-10 times of distillation water logging measured is added
Bubble 4-5 hours, heating are boiled 3-4 hours, and immersion liquid is extracted；The 6-8 times of distilled water measured is added again, heating is boiled 2-3 hours, carried
Take immersion liquid；The 4-6 times of distilled water measured finally is added, heating is boiled 1-2 hours, and immersion liquid is extracted；Merge immersion liquid three times, filter,
It is spare to obtain filtrate；
（3）Net licorice tablet is taken, cooked honey and a little boiling water is added, it is slightly bored after mixing thoroughly, it sets in frying container, is fried with slow fire depth
Yellow is taken out when tack-free, cools, and crushing is ground, and crosses 140 mesh dusting covers, obtains fine powder, spare；
（4）Radix paeoniae rubra piece is taken, yellow rice wine is added to mix thoroughly, it is slightly bored, after wine is sucked, sets in preheating frying container, heated with slow boiling, fried extremely
Yellowish, taking-up is dried in the air cool, weeds out clast, and crushing is ground, and is crossed 140 mesh dusting covers, is obtained fine powder, spare；
（5）Take the sprinkling of Rhizoma Chuanxiong piece yellow rice wine uniform, slightly bored, it is degree to set stir-fry to micro- coke in pot, and taking-up cools, and crushing is ground, and crosses 140
Mesh dusting cover obtains fine powder, spare；
（6）Cooked honey and a little boiling water is added in Radix Polygalae, is mixed thoroughly, it is slightly bored, it puts and fries in pot to tack-free, taking-up is dried in the air cool, powder
It is broken to grind, 140 mesh dusting covers are crossed, fine powder is obtained, it is spare；
（7）Styrax crushing is ground, 140 mesh dusting covers is crossed, obtains fine powder, it is spare；
（8）By step（1）, step（2）The filtrate of gained, with step（3）, step（4）, step（5）, step（6）, step（7）
The fine powder of middle gained mixes, and adds auxiliary material sucrose and dextrin to be uniformly mixed and particle is made, and after dry, whole grain, is packaged into every bag of 6g's
Instant particles as Chinese medicine.
The pharmacological property of Chinese medicine used in the present invention is as follows：
Arillus longan：It is sweet in flavor；It is warm-natured.Enter the heart；Kidney；Liver；The spleen channel.Bushing spleen；Replenishing qi and blood；Tranquilizing mind.Cure mainly the insufficiency of heart and spleen, qi and blood not
Palpitation with fear caused by foot；Palpitation；Insomnia；It is forgetful；Blood deficiency chlorosis；Irregular menstruation；Uterine bleeding.《It obtains with book on Chinese herbal medicine》It carries：" Energy benefit taste preserves the heart
Blood, moisturizing viscera control palpitation." modern medical studies have confirmed that arillus longan has obviously cardiac muscle by the stimulation of low temperature, high temperature and anoxic
Protective effect, have inhibiting effect to Microsporon audouini, in addition there are calm and digestion promoting functions.
Wild rice stem：It is sweet in flavor；It is cold in nature.Return liver；Spleen；Lung channel.Relieving heat toxin；Relieving thirst and restlessness；Profit two is just.Cure mainly dysphoria with smothery sensation；It quenches one's thirst；Constipation and anuresis；
Jaundice；Dysentery；Heat gonorrhea；Hot eyes；Newborn sweat not under；Sore.《Bencao Shiyi》：Dysphoria with smothery sensation is gone, is quenched the thirst, except mesh is yellow, sharp stool and urine is only hot
Dysentery, relieving alcoholism.
Radix pseudostellariae：It is sweet in flavor;Slight bitter；Cold nature.Returns spleen, lung channel.Help spleen and lung；Nourishing generate fluid.It cures mainly weakness of the spleen and the stomach；Appetite
It is depressed；Lassitude；Impairment of both QI and YIN；Dry cough phlegm is few；Spontaneous perspiration shortness of breath；And the convalescent stage of febrile disease deficiency of vital energy Tianjin wound；Interior heat is thirsty；Or nerve
It is weak, palpitation and insomnia, dizzy forgetful, Infantile Summer Fever.《Shaanxi Chinese herbal medicine》：Invigorating qi and benefiting blood, invigorating the spleen are promoted the production of body fluid.It is physically weak after curing the disease,
Cough due to deficiency of the lung, insufficiency of the spleen diarrhoea, children's abnormal sweating, palpitaition, dry, do not feel like eating.Modern medicine study proves：Radix pseudostellariae has body
There are adaptive significances, defence capability of the body to various destructive stimulus can be enhanced, can also enhance the metabolism in human body.
Gynostemma pentaphylla：Bitter；Micro-sweet；It is cool in nature.Return lung；Spleen；Kidney channel.Nourishing heart invigorating the spleen, QI invigorating and blood, clearing heat and detoxicating, eliminating the phlegm
The stasis of blood.It cures mainly：It is physically weak weak；Nephrasthenia emission；Leukopenia；Hyperlipidemia；Virus hepatitis；Chronic gastroenteritis；Chronic gas
Guan Yan.《The small book series of Ming and Qing TCM Clinical》Described in：Gynostemma pentaphylla boosting qi and nourishing yin, clearing lung and eliminating phlegm, mental-tranquilization, production of sperm controlling nocturnal emission with astringent drugs.It is existing
It is found for medical research, gynostemma pentaphylla principle active component is polysaccharide, flavonoids, saponins and microelement kind, effect master
If promoting the metabolism of body fat substance, nutrition human body cell, while there is good detoxicating, relieving inflammation effect, is widely used in
Hyperlipidemia, fatty liver, obesity, constipation, insomnia, hepatitis B, chronic airway inflammation（Sphagitis, enterogastritis etc.）Treatment and guarantor
It is strong.
Jujube：It is sweet in flavor；It is warm-natured.Returns spleen；Stomach.Tonifying spleen and stomach；Replenishing qi and blood；Tranquilizing mind；Battalion is adjusted to defend；And pharmacological property.Cure mainly taste
It is weak；Insufficiency of vital energy and blood；Anorexia and loose stool；Lassitude hypodynamia；Palpitation and insomnia；Hysteria of womam；It is disharmony between ying and wei.Li Gao：Temperature is with tonifying spleen through not
Foot, it is sweet with slow cloudy blood and negative and positive, adjust battalion to defend, born fluid.
Thatch screwpine fruit：Acrid flavour；It is light；It is cool in nature.Return kidney；Spleen；Liver；Stomach.Tonifying spleen benefit blood；Promoting qi circulation and relieving pain；Resolving sputum dampness removing；Improving eyesight.
Cure mainly dysentery；Stomachache；Cough；Hernia；Orchitis；Hemorrhoid difficult urination；Mesh gives birth to ocular.《Detailed outline is picked up any lost article from the road》：Tonifying spleen and stomach, Gu member
Gas subdues high sun, helps the soil that declines, and strengthens spirit, and beneficial blood, wide ruffian, dissolving phlegm, relieving alcoholism, only hair is thirsty after drinking, the sharp head, happily benefit will.
Buckbean：It is sweet in flavor；Slight bitter；It is cold in nature.The thoughts of returning home；The spleen channel.Reinforcing spleen to promote digestion；Mental-tranquilization；Reducing fever and causing diuresis.Cure mainly gastritis；Disappear
Change bad；Palpitation and insomnia；Jaundice with damp-heat pathogen；Cholecystitis；Oedema；Difficult urination or fervid puckery pain.《Detailed outline》：Heart diaphragm heat symptoms caused by an exopathgen are controlled, no
It must sleep.
The seed of Oriental arborvitae：It is sweet in flavor；It is mild-natured.The thoughts of returning home；Kidney；Large intestine channel.Mental-tranquilization；Arrest sweating；It relaxes bowel.Cure mainly palpitation with fear palpitation；
Insomnia forgetfulness；Night sweat；Dry constipation of intestines.《Drugization justice》It carries：" the saturating heart of fragrance, body profit grow blood, and it is timid to cure mainly mind void, palpitation of palpitating with fear,
Color is wan and sallow, and skin is dry to itch, all the work(of nourishing heart blood." modern medical studies have confirmed that the seed of Oriental arborvitae contains a large amount of unsaturated fats
Sour, a small amount of volatile oil and multivitamin, saponin(e, phytosterol and protein improve immunity of organisms, are chiefly used in treatment variation
Property angina pectoris and rheumatic coronary heart disease.
Hoveniae semoveniae semen：It is sweet in flavor；It is mild-natured.The thoughts of returning home；Spleen；Lung channel.Relieving alcoholism；Quench the thirst relieving restlessness；Preventing or arresting vomiting；Sharp stool and urine.It cures mainly drunk；
Polydipsia；Vomiting；Difficulty in urination and defecation.《The southern regions of the Yunnan Province book on Chinese herbal medicine》：All left right paralysis of paralysis are controlled, rheumatic numbness can relieving alcoholism；Or steep in wine and take it, also
It can relaxing muscles and tendons network.Children take it, change worm, support spleen.
The tuber of dwarf lilyturf：It is sweet in flavor；Slight bitter；It is cold in nature.Return lung；Stomach；The heart channel of Hang-Shaoyin.Nourishing Yin and moistening lung；Reinforcing stomach reg fluid；Relieving restlessness that clears away heart-fire.Cure mainly lung
Dry dry cough；Lung carbuncle；Deficiency of yin and overstrain cough；Injury thirst；It quenches one's thirst；Vexed insomnia；It has sore throat；Dry constipation of intestines；Blood-head tells nosebleed.《Book on Chinese herbal medicine
It converges and says》：The tuber of dwarf lilyturf, the medicine of heart clearing, lung moistening.Main deficiency of heart-QI, palpitation of palpitating with fear is forgetful in a trance, spirit fall；Or the lung heat dryness of the lung,
Cough sound running fire, consumptive lung disease leaf scorch, short dyspnea due to deficiency of vital energy, fire lie prostrate in lung, hemoptysis of spitting blood；Or consumptive disease visitor's heat, body fluid are dry few；Or taste are dry dries up,
It is empty secret just difficult；This all strongly fragrant card of the cardiopulmonary kidney spleen member fire of deficiency type.However gas sweet in flavor is flat, the beneficial lung gold of energy, bitter is cold in nature, can drop internal heat,
Body, which moistens matter, to be mended, and kidney marrow can be supported, and the work(for specially controlling strain abnormal heat is in the majority.Such as the preceding main stagnation of vital energy in the chest and abdomen of Gu, hinders and slander full, stomach channels is exhausted, thin
The thin diseases such as lose heart, then it is bright to belong to strain.
Rhizoma zingiberis：Acrid flavour；Property heat.Returns spleen；Stomach；The heart；Lung channel.Warming spleen and stomach for dispelling cold；Recover Yang and smooth venation；Warming lung and resolving fluid.It cures mainly：Gastral cavity abdomen is cold
Bitterly；Vomiting；Diarrhea, yang depletion are fainted inverse；Cold drink is breathed with cough；Numbness and ache of cold dampness.《Medicine origin》：《Cure mainly secret want》Cloud leads to the motive, supporing yang,
Go internal organs heavy cold, send out all through cold air, control the cold abdominal pain of sense.Modern medicine study discovery, rhizoma zingiberis preserved material Central nervous, angiocarpy
System, digestive system have apparent effect.
Folium Pleioblasti：Bitter；It is cold in nature.The thoughts of returning home；Liver Channel.Clear away heart-fire；Diuresis improving eyesight；Removing toxic substances.Cure mainly pyreticosis polydipsia；Insomnia；Urine
It is short red；Aphtha；Mesh pain；Aphonia；Burn and scald.《Japan hanako materia medica》：" it controls and sits up, only quench one's thirst, relieving alcoholism, relieving restlessness thermal sweating, in controlling
Wind aphonia."
Radix Glycyrrhizae：It is sweet in flavor；It is mild-natured.The thoughts of returning home；Lung；Spleen；Stomach.It invigorates the spleen and benefits qi；It is clearing heat and detoxicating；Expelling phlegm and arresting coughing；Relieving spasm to stop pain；It reconciles all
Medicine.It cures mainly weakness of the spleen and the stomach；Lassitude hypodynamia；Palpitation；Coughing with a lot of sputum；Gastral cavity abdomen four limbs contraction；Carbuncle sore tumefacting virus；Alleviate drug
Toxicity.《Compendium of Materia Medica》It carries：" Radix Glycyrrhizae is monarch in all medicines.Control 72 kinds of mammary calculus poison, the draft poison by every means of solution 1,002, reconcile from
Medicine is active." modern medical studies have confirmed that Radix Glycyrrhizae has stronger detoxication, also antiulcer, anti-inflammatory, antispastic antibechic, drop blood
Pressure, reducing blood lipid, antitumaous effect are widely used in the diseases such as treatment sphagitis, laryngitis, tracheitis, bronchitis, asthma, cough, hemoptysis
Disease additionally has anti-gastric-ulcer, gastritis effect.
Rose rhodobryum herb：It is lightly seasoned；Slight bitter；It is mild-natured.Thoughts of returning home warp.Mental-tranquilization；It is calm.Cure mainly heart disease；It is nervous；Palpitation and severe palpitation；
Neurasthenia.《Simao, Yunnan Chinese herbal medicine selects》：Calm the nerves calm.Control nervous, palpitaition, heart disease.Modern medicine study proves：Hui Xin
Grass can increase coronary blood flow, improve the nutritional blood flow of ischemic region, and have anticoagulant effect, and blood viscosity is decreased obviously, and is had
Apparent decompression, effect for reducing blood fat.
Radix paeoniae rubra：Bitter；It is slightly cold.Return liver warp.Clearing heat and cooling blood；Promoting blood circulation.Cure mainly febrile virulent maculae；Hematemesis and epistaxis；Under intestines wind
Blood；Red eye, swell pain；Carbuncle swells sore；Amenorrhoea；Dysmenorrhoea；Collapse band stranguria with turbid discharge；The stagnant hypochondriac pain of the stasis of blood；Hernia lump in the abdomen is gathered；Injury from falling down.《Legendary god of farming's book on Chinese herbal medicine
Through》It carries：" bitter is flat, main perverse trend abdominal pain, except blood-arthralgia, broken hard product fever and chills hernia lump in the abdomen, analgesic, raw Chuan Gu." modern medical studies have confirmed that
Radix paeoniae rubra has anti-thrombosis function, antiplatelet aggregative activity, reducing blood lipid and anti arteriosclerosis effect, and to cardiovascular system
There are certain influence, water-alcohol extraction to have significant sedation and analgesic effect, can slightly improve the acidity of gastric juice, can be used for
Improve appetite, digestive function and certain neuropathies.
Clear eggplant：Acrid flavour；Slight bitter；It is warm-natured.Returns spleen；Stomach；Kidney channel.Warm in pain；The promoting flow of qi and blood circulation；It relievings asthma；Diuresis.Cure mainly gastral cavity
Abdomen crymodynia；Dyspepsia inflatable；Gastric disorder causing nausea vomiting；Heatstroke is vomited and diarrhoea；Dysentery；Cold hernia stomachache；Asthma；Cold-dampness ascites；Difficult urination；It is small
Just muddy；Sore swollen toxin；Toothache；Numbness and ache of cold dampness；Traumatic injury.Modern medicine study proves：Clear eggplant is poly- with antiplatelet
Collection effect, resisting myocardial ischemia acts on myocardial infarction, relievings asthma and anti-allergic effects, antibacterial action and litholytic effect.
Rhizoma Chuanxiong：Acrid flavour；It is warm-natured.Return liver；Courage；Pericardium channel.Promoting blood circulation；Promote breath and open depression；Wind-expelling pain-stopping.Zhu Zhi wei lumps in the abdomen are swollen
Block；Pain in chest and hypochondrium；Dizziness of having a headache；Wind-cold-dampness arthralgia；Traumatic injury；Ulcer sores.《Book on Chinese herbal medicine is just》It carries：" dispersing wind and cold controls pain, broken stasis of blood
It stores, promoting blood circulation, unhitch gas, by pain, apocenosis detumescence, by blood promoting menstruation." modern medical science is the study found that Rhizoma Chuanxiong extracting solution pair
Leukaemia cell is inhibited to have a certain effect, preparation has certain antibacterial action, especially to typhoid bacillus, paratyphosum Bacterium, suddenly
Random vibrios, Pseudomonas aeruginosa and pathogenic dermatophyte etc. have inhibiting effect, and the ligustrazine, ferulic acid contained by Rhizoma Chuanxiong are received with work
Blood stagnation resolvation effect, expansible coronary artery promotes coronary flow, allevating angina pectoris, and has anti-thrombosis function, contained
The effects that ligustilide has smooth muscle spasmolysis and inhibits myenteron, uterine contractile.
Horseradish grass：Acrid flavour；It is warm-natured.Warming meridians and promoting circulation of qi；Promoting blood circulation and stopping pain.Cure mainly coronary heart disease；Angina pectoris；Thrombosis-obstructive vessel
It is scorching；Arthritis；Pernio.Modern medicine study proves：Horseradish grass energy coronary artery dilator increases coronary flow, improves myocardium generation
It thanks, reduces oxygen demand, also there is anticoagulation, reducing blood lipid and anti-inflammatory effect.
Dried orange peel：Acrid flavour；It is sweet；It is cold in nature.Enter spleen；Stomach.Lower gas；In tune；Resolving sputum；It sobers up.Cure mainly feeding desorder；Upper gas is tired
It is full；It gets sick from drinking too much wine thirsty.《Japan hanako materia medica》It carries：" soup is made in skin toast, can relieving alcoholism and wine it is thirsty, typhoid fever diet labor answer person, and dense pan-fried juice takes.”
Medicine clinical research shows that the aurantiamarin contained by dried orange peel can inhibit gastric ulcer, reduces capillary permeability, has adjustment stomach
Function and anti-inflammatory effect, volatile oil have the effects that eliminating the phlegm, relieving asthma, promote digestive juice secretion and exclude enteral pneumatosis, this
There is coronary artery dilator outside, reduce blood pressure and the effects that cholagogic.
High mountain enchanter's nightshade：It is sweet in flavor；It is bitter；Cold nature.Mental-tranquilization；It helps digestion；Cough-relieving；Removing toxic substances；It is antipruritic.Cure mainly palpitaition；Insomnia；
Dreaminess；Infantile malnutrition due to digestive disturbances or intestinalparasites；Cough；Sore abscess；Condyloma；Tinea is itched.
Bush：It is sweet in flavor；It is salty；It is mild-natured；It is nontoxic.The thoughts of returning home；Liver；Stomach；Large intestine channel.Promoting blood circulation, detumescence ding-tong.Cure mainly married woman's blood
Stagnant Amenorrhea, dysmenorrhoea, postpartum stasis pain in the chest and abdomen, postpartum anemic fainting, carbuncle swells, traumatic injury, lockjaw.《Book on Chinese herbal medicine is looked for the truth》：Bush, function
Have class safflower, it is few with then can and blood, it is multi-purpose then can blood-breaking.But safflower slightly warm in nature and, then cold nature is cool for this.Therefore in all cause of disease tables
Wind rise, and cause stasis not all right and postpartum anemic fainting turgor with dead and blood pain blood lump in the abdomen, through diseases such as heap soil or fertilizer over and around the roots of holding one's breath, carbuncle swells, injury from falling down, all
Suitable phase disease is closed is recuperated under medical treatment with his medicine.Modern study proves that：Bush can increase coronary flow, reduce coronary resistance, reduce heart rate, lower
Left room work done, can significantly reduce blood viscosity, have antitumaous effect；Also inhibit the effect of aldose reductase.
Grass-leaved sweetflag：Acrid flavour；It is bitter；Slightly warm in nature.The thoughts of returning home；Liver；The spleen channel.Dissipating phlegm for resuscitation；Dampness elimination promoting the circulation of qi；Wind-dispelling profit numbness；Detumescence stops
Bitterly.Cure mainly pyreticosis coma；Coma due to blocking of the respiratory system；It is forgetful；Tinnitus；It is deaf；Abdominal distention；Dysentery with vomiting；Arthralgia pain due to rheumatism；Traumatic injury；Ulcer scabies
Tinea.《Chongqing hall random notes》：Grass-leaved sweetflag, comfortable gas, the smooth mind, happy mood, invigorating heart will, panacea.Removing summer-heat it is medicinal it, eliminating the phlegm of relying
It is dirty turbid and defend city wall, nourish it is medicinal it, so as to declaring the knot of thought and being proficient in the law of natural movement.
Radix Polygalae：Bitter；It is pungent；It is warm-natured.The thoughts of returning home；Kidney；Lung channel.Tranquilize the mind and promote the intelligence；Eliminating the phlegm；Detumescence.Caused by curing mainly breakdown of the normal physiological coordination between the heart and the kidney
Insomnia and dreamful sleep, forgetful palpitation with fear is wandering, and expectoration is not well, sore swollen toxin, mastosis.《Sheng Nong's herbal classic》It carries：" main cough is inverse
In wound, tonifying for the deficiency, remove pathogenic factor, sharp nine orifices, intelligence development is intelligent, and normal hearing and eyesight is not forgotten, strong will times power." modern medical studies have confirmed that remote
Will has calm, anticonvulsant action, has excited stimulation to smooth muscle and cardiac muscle, in addition there are inhibit alcohol absorption, it is anti-oxidant,
The effects that anti-aging.
Styrax：Acrid flavour；It is bitter；It is mild-natured.The thoughts of returning home；Liver；The spleen channel.Inducing resuscitation of having one's ideas straightened out；Slit phlegm is warded off dirty；The promoting flow of qi and blood circulation；Analgesic.It cures mainly
Middle wind phlegm Jue；Frightened epilepsy is gone into a coma, postpartum anemic fainting；Trusted subordinate's pain；The wandering arthritis arthrodynia of extremeties.《The new compilation of materia medica》：Suitable qi and blood circulation promotion.It grinds and takes under promoting circulation of blood
Gas is calmed the nerves.Modern medicine study proves：Benzoic tincture is stimulant expectorant, and styrax still has antisepsis in addition.
Compared with prior art, the present invention having the advantages that：
The present invention selects medicinal material monarch, minister, a left side, keeps all reasons all standby, and pharmacological property is mutually suitable mutually auxiliary, suits the remedy to the case for the cause of disease, has nourishing heart strong
Spleen, boosting qi and nourishing yin, warming meridians and promoting circulation of qi, the promoting flow of qi and blood circulation, promoting blood circulation, resolving sputum dampness removing, removing toxic substances sober up, mental-tranquilization, reducing fever and causing diuresis it
Effect, good absorption effect is significant in efficacy, has no toxic side effect and clinical adverse, controls according to clinical verification alcoholic myocardiopathy
More rate is higher.
Specific implementation mode
Present invention is further elaborated in following combination specific embodiment.
Embodiment 1
The raw material of effective ingredient of the present invention forms and weight is：
15~35 parts of arillus longan, 15~35 parts of wild rice stem, 15~35 parts of radix pseudostellariae, 15~30 parts of gynostemma pentaphylla,
15~30 parts of jujube, 15~25 parts of thatch screwpine fruit, 15~25 parts of buckbean, 15~25 parts of the seed of Oriental arborvitae,
10~20 parts of hoveniae semoveniae semen, 10~20 parts of the tuber of dwarf lilyturf, 10~20 parts of rhizoma zingiberis, 9~15 parts of Folium Pleioblasti,
9~15 parts of Radix Glycyrrhizae, 9~15 parts of rose rhodobryum herb, 6~12 parts of radix paeoniae rubra, 6~12 parts of clear eggplant,
4~10 parts of Rhizoma Chuanxiong, 4~10 parts of horseradish grass, 4~10 parts of dried orange peel, 3~9 parts of high mountain enchanter's nightshade,
3~9 parts of bush, 2~6 parts of grass-leaved sweetflag, 1~4 part of Radix Polygalae, 1~4 part of styrax.
The processing step of process for preparing medicine of the present invention is：
（1）By arillus longan, thatch screwpine fruit, hoveniae semoveniae semen, clean be put into container, be added 4 times amount concentration 80% ethanol solution, leaching
It is spare to obtain filtrate for bubble 1-2 hours, heating and refluxing extraction 3-4 hours, filtering；
（2）By wild rice stem, radix pseudostellariae, gynostemma pentaphylla, jujube, buckbean, the seed of Oriental arborvitae, the tuber of dwarf lilyturf, rhizoma zingiberis, Folium Pleioblasti, rose rhodobryum herb, clear eggplant
Son, horseradish grass, dried orange peel, high mountain enchanter's nightshade, bush, grass-leaved sweetflag are put into after cleaning in container, and the 8-10 times of distillation water logging measured is added
Bubble 4-5 hours, heating are boiled 3-4 hours, and immersion liquid is extracted；The 6-8 times of distilled water measured is added again, heating is boiled 2-3 hours, carried
Take immersion liquid；The 4-6 times of distilled water measured finally is added, heating is boiled 1-2 hours, and immersion liquid is extracted；Merge immersion liquid three times, filter,
It is spare to obtain filtrate；
（3）Net licorice tablet is taken, cooked honey and a little boiling water is added, it is slightly bored after mixing thoroughly, it sets in frying container, is fried with slow fire depth
Yellow is taken out when tack-free, cools, and crushing is ground, and crosses 140 mesh dusting covers, obtains fine powder, spare；
（4）Radix paeoniae rubra piece is taken, yellow rice wine is added to mix thoroughly, it is slightly bored, after wine is sucked, sets in preheating frying container, heated with slow boiling, fried extremely
Yellowish, taking-up is dried in the air cool, weeds out clast, and crushing is ground, and is crossed 140 mesh dusting covers, is obtained fine powder, spare；
（5）Take the sprinkling of Rhizoma Chuanxiong piece yellow rice wine uniform, slightly bored, it is degree to set stir-fry to micro- coke in pot, and taking-up cools, and crushing is ground, and crosses 140
Mesh dusting cover obtains fine powder, spare；
（6）Cooked honey and a little boiling water is added in Radix Polygalae, is mixed thoroughly, it is slightly bored, it puts and fries in pot to tack-free, taking-up is dried in the air cool, powder
It is broken to grind, 140 mesh dusting covers are crossed, fine powder is obtained, it is spare；
（7）Styrax crushing is ground, 140 mesh dusting covers is crossed, obtains fine powder, it is spare；
（8）By step（1）, step（2）The filtrate of gained, with step（3）, step（4）, step（5）, step（6）, step（7）
The fine powder of middle gained mixes, and adds auxiliary material sucrose and dextrin to be uniformly mixed and particle is made, and after dry, whole grain, is packaged into every bag of 6g's
Instant particles as Chinese medicine.
Usage and dosage：Boiling water is taken after mixing it with water, 1 time 1 bag, morning and evening sub-service, 1 month be 1 course for the treatment of.
Embodiment 2
The raw material of effective ingredient of the present invention forms and weight is：
20~32 parts of arillus longan, 18~30 parts of wild rice stem, 18~30 parts of radix pseudostellariae, 18~25 parts of gynostemma pentaphylla,
18~25 parts of jujube, 18~22 parts of thatch screwpine fruit, 18~22 parts of buckbean, 18~22 parts of the seed of Oriental arborvitae,
13~18 parts of hoveniae semoveniae semen, 13~18 parts of the tuber of dwarf lilyturf, 12~16 parts of rhizoma zingiberis, 11~14 parts of Folium Pleioblasti,
11~13 parts of Radix Glycyrrhizae, 11~13 parts of rose rhodobryum herb, 8~10 parts of radix paeoniae rubra, 8~10 parts of clear eggplant,
6~9 parts of Rhizoma Chuanxiong, 6~9 parts of horseradish grass, 6~9 parts of dried orange peel, 5~8 parts of high mountain enchanter's nightshade,
5~8 parts of bush, 3~5 parts of grass-leaved sweetflag, 2~4 parts of Radix Polygalae, 1~3 part of styrax.
The process for preparing medicine processing step and usage and dosage of the present embodiment are same as Example 1.
Embodiment 3
The raw material of effective ingredient of the present invention forms and weight is：
28 parts of arillus longan, 26 parts of wild rice stem, 26 parts of radix pseudostellariae, 23 parts of gynostemma pentaphylla,
22 parts of jujube, 20 parts of thatch screwpine fruit, 20 parts of buckbean, 20 parts of the seed of Oriental arborvitae,
16 parts of hoveniae semoveniae semen, 16 parts of the tuber of dwarf lilyturf, 14 parts of rhizoma zingiberis, 13 parts of Folium Pleioblasti,
12 parts of Radix Glycyrrhizae, 12 parts of rose rhodobryum herb, 9 parts of radix paeoniae rubra, 9 parts of clear eggplant,
8 parts of Rhizoma Chuanxiong, horseradish grass 8 parts, 8 parts of dried orange peel, 7 parts of high mountain enchanter's nightshade,
6 parts of bush, 4 parts of grass-leaved sweetflag, 3 parts of Radix Polygalae, 2 parts of styrax.
The process for preparing medicine processing step and usage and dosage of the present embodiment are same as Example 1.
Clinical data：
1, case selection
68 clinical observations of alcoholic myocardiopathy patient that selection our hospital makes a definite diagnosis, patient are randomly divided into two groups.Treatment group 34,
Middle male 31, women 3,39~63 years old age, average age 48.6 years old, average history of drinking history（16.36±1.92）Year；Control
Group 34, wherein male 30, women 4,37~62 years old age, average age 47.3 years old, average history of drinking history（16.51±
1.87）Year.Two groups of qualifications and record of service are almost the same, and no significant difference is comparable.
2, therapy
The complete abstinence from alcohol of two groups of patients, treatment group patient take drug of the present invention, and boiling water is taken after mixing it with water, 1 time 1 bag, morning and evening sub-service, 1
The moon is 1 course for the treatment of, is taken 3 course for the treatment of.Control group is given conventional medicine and is controlled according to the classification for the alcoholic myocardiopathy being diagnosed to be
It treats, and suits the medicine to the illness and give cardiac stimulant, diuresis, expansion blood vessel, angiotensin converting enzyme inhibitor or G- Adrenergic receptor blockers
Equal class of medications.
3, efficacy determination：
（1）Recovery from illness：Cardiac shape structure and heart function restore normal completely.
（2）It improves：Cardiac shape and funtion part are restored, and center function improves earlier above, but still are 2-3 grades.
（3）In vain：Symptom is same to treat preceding no significant difference.
4, treatment results
26 are cured in treatment group, are improved 6, invalid 2, cure rate 76.5%, total effective rate 94.1%.
18 are cured in control group, are improved 10, invalid 6, cure rate 52.9%, total effective rate 82.4%.
The above results show that the cure rate and total effective rate for the treatment of group are apparently higher than control group.
Model case is illustrated：
1, Zhao's ××, man, 55 years old.The patient drinks more than 10 years, daily drinking amount 150ml or more, after work in nearly 1 year is tired before the heart
Area's pain, for slight bored pain, 1 to 2 minutes every time, more than it is tired, excited when induce, delay after rest or buccal nitroglycerin
Solution, Relapse rate breaking-out.Carry out institute's interrogation later, alcoholic myocardiopathy is diagnosed as after inspection, through taking Chinese medicine of the present invention
After 1 course for the treatment of of electuary, readme pain symptom is substantially reduced, follows the doctor's advice after continuing to take 2 courses for the treatment of of Chinese medicine of the present invention, pain
Sense completely disappears, and above-mentioned symptom completely disappears, and 3 moonset recurrences of follow-up have been fully recovered.
2, neat ××, man, 58 years old.15 years history of drinking history of patient, daily drinking amount 200ml or more, have within nearly 2 years shortness of breath uncomfortable in chest,
The malaise symptoms such as palpitation and uneasiness, insomnia and dreamful sleep carried out institute's interrogation, and were diagnosed as alcoholic myocardiopathy after inspection later, through taking this
After inventing 3 courses for the treatment of of the instant particles as Chinese medicine, above-mentioned symptom completely disappears, and 3 moonset recurrences of follow-up have been fully recovered.
Claims (4)
1. a kind of instant particles as Chinese medicine for treating alcoholic myocardiopathy, which is characterized in that the raw material group of the effective ingredient is made
At and parts by weight be：
15~35 parts of arillus longan, 15~35 parts of wild rice stem, 15~35 parts of radix pseudostellariae, 15~30 parts of gynostemma pentaphylla,
15~30 parts of jujube, 15~25 parts of thatch screwpine fruit, 15~25 parts of buckbean, 15~25 parts of the seed of Oriental arborvitae,
10~20 parts of hoveniae semoveniae semen, 10~20 parts of the tuber of dwarf lilyturf, 10~20 parts of rhizoma zingiberis, 9~15 parts of Folium Pleioblasti,
9~15 parts of Radix Glycyrrhizae, 9~15 parts of rose rhodobryum herb, 6~12 parts of radix paeoniae rubra, 6~12 parts of clear eggplant,
4~10 parts of Rhizoma Chuanxiong, 4~10 parts of horseradish grass, 4~10 parts of dried orange peel, 3~9 parts of high mountain enchanter's nightshade,
3~9 parts of bush, 2~6 parts of grass-leaved sweetflag, 1~4 part of Radix Polygalae, 1~4 part of styrax.
2. a kind of instant particles as Chinese medicine for treating alcoholic myocardiopathy according to claim 1, which is characterized in that the medicine is made
The raw material of object active ingredient forms and parts by weight are：
20~32 parts of arillus longan, 18~30 parts of wild rice stem, 18~30 parts of radix pseudostellariae, 18~25 parts of gynostemma pentaphylla,
18~25 parts of jujube, 18~22 parts of thatch screwpine fruit, 18~22 parts of buckbean, 18~22 parts of the seed of Oriental arborvitae,
13~18 parts of hoveniae semoveniae semen, 13~18 parts of the tuber of dwarf lilyturf, 12~16 parts of rhizoma zingiberis, 11~14 parts of Folium Pleioblasti,
11~13 parts of Radix Glycyrrhizae, 11~13 parts of rose rhodobryum herb, 8~10 parts of radix paeoniae rubra, 8~10 parts of clear eggplant,
6~9 parts of Rhizoma Chuanxiong, 6~9 parts of horseradish grass, 6~9 parts of dried orange peel, 5~8 parts of high mountain enchanter's nightshade,
5~8 parts of bush, 3~5 parts of grass-leaved sweetflag, 2~4 parts of Radix Polygalae, 1~3 part of styrax.
3. a kind of instant particles as Chinese medicine for treating alcoholic myocardiopathy according to claim 1, which is characterized in that the medicine is made
The raw material of object active ingredient forms and parts by weight are：
28 parts of arillus longan, 26 parts of wild rice stem, 26 parts of radix pseudostellariae, 23 parts of gynostemma pentaphylla,
22 parts of jujube, 20 parts of thatch screwpine fruit, 20 parts of buckbean, 20 parts of the seed of Oriental arborvitae,
16 parts of hoveniae semoveniae semen, 16 parts of the tuber of dwarf lilyturf, 14 parts of rhizoma zingiberis, 13 parts of Folium Pleioblasti,
12 parts of Radix Glycyrrhizae, 12 parts of rose rhodobryum herb, 9 parts of radix paeoniae rubra, 9 parts of clear eggplant,
8 parts of Rhizoma Chuanxiong, horseradish grass 8 parts, 8 parts of dried orange peel, 7 parts of high mountain enchanter's nightshade,
6 parts of bush, 4 parts of grass-leaved sweetflag, 3 parts of Radix Polygalae, 2 parts of styrax.
4. a kind of preparation method of instant particles as Chinese medicine that treating alcoholic myocardiopathy, which is characterized in that comprise the following steps that：
（1）By arillus longan, thatch screwpine fruit, hoveniae semoveniae semen, clean be put into container, be added 4 times amount concentration 80% ethanol solution, leaching
It is spare to obtain filtrate for bubble 1-2 hours, heating and refluxing extraction 3-4 hours, filtering；
（2）By wild rice stem, radix pseudostellariae, gynostemma pentaphylla, jujube, buckbean, the seed of Oriental arborvitae, the tuber of dwarf lilyturf, rhizoma zingiberis, Folium Pleioblasti, rose rhodobryum herb, clear eggplant
Son, horseradish grass, dried orange peel, high mountain enchanter's nightshade, bush, grass-leaved sweetflag are put into after cleaning in container, and the 8-10 times of distillation water logging measured is added
Bubble 4-5 hours, heating are boiled 3-4 hours, and immersion liquid is extracted；The 6-8 times of distilled water measured is added again, heating is boiled 2-3 hours, carried
Take immersion liquid；The 4-6 times of distilled water measured finally is added, heating is boiled 1-2 hours, and immersion liquid is extracted；Merge immersion liquid three times, filter,
It is spare to obtain filtrate；
（3）Net licorice tablet is taken, cooked honey and a little boiling water is added, it is slightly bored after mixing thoroughly, it sets in frying container, is fried with slow fire depth
Yellow is taken out when tack-free, cools, and crushing is ground, and crosses 140 mesh dusting covers, obtains fine powder, spare；
（4）Radix paeoniae rubra piece is taken, yellow rice wine is added to mix thoroughly, it is slightly bored, after wine is sucked, sets in preheating frying container, heated with slow boiling, fried extremely
Yellowish, taking-up is dried in the air cool, weeds out clast, and crushing is ground, and is crossed 140 mesh dusting covers, is obtained fine powder, spare；
（5）Take the sprinkling of Rhizoma Chuanxiong piece yellow rice wine uniform, slightly bored, it is degree to set stir-fry to micro- coke in pot, and taking-up cools, and crushing is ground, and crosses 140
Mesh dusting cover obtains fine powder, spare；
（6）Cooked honey and a little boiling water is added in Radix Polygalae, is mixed thoroughly, it is slightly bored, it puts and fries in pot to tack-free, taking-up is dried in the air cool, powder
It is broken to grind, 140 mesh dusting covers are crossed, fine powder is obtained, it is spare；
（7）Styrax crushing is ground, 140 mesh dusting covers is crossed, obtains fine powder, it is spare；
（8）By step（1）, step（2）The filtrate of gained, with step（3）, step（4）, step（5）, step（6）, step（7）
The fine powder of middle gained mixes, and adds auxiliary material sucrose and dextrin to be uniformly mixed and particle is made, and after dry, whole grain, is packaged into every bag of 6g's
Instant particles as Chinese medicine.
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| WO2014144776A1 (en) * | 2013-03-15 | 2014-09-18 | Alltech, Inc. | Compositions comprising selenium and use of same for the treatment and prevention of disease or conditions associated with mitochondrial dysfunction |
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