CN108283647B - 甘露糖醛二酸的组合物 - Google Patents
甘露糖醛二酸的组合物 Download PDFInfo
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- CN108283647B CN108283647B CN201711467596.6A CN201711467596A CN108283647B CN 108283647 B CN108283647 B CN 108283647B CN 201711467596 A CN201711467596 A CN 201711467596A CN 108283647 B CN108283647 B CN 108283647B
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- combination
- sum
- oligomannuronate
- mannuronic
- acid
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7016—Disaccharides, e.g. lactose, lactulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7032—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a polyol, i.e. compounds having two or more free or esterified hydroxy groups, including the hydroxy group involved in the glycosidic linkage, e.g. monoglucosyldiacylglycerides, lactobionic acid, gangliosides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/734—Alginic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/04—Disaccharides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0084—Guluromannuronans, e.g. alginic acid, i.e. D-mannuronic acid and D-guluronic acid units linked with alternating alpha- and beta-1,4-glycosidic bonds; Derivatives thereof, e.g. alginates
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Materials Engineering (AREA)
- Polymers & Plastics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
Description
二糖 | 三糖 | 四糖 | 五糖 | 六糖 | 七糖 | 八糖 | 九糖 | 十糖 | |
A | 19% | 25% | 22% | 13% | 9% | 6% | 3% | 2% | 1% |
B | 24% | 25% | 19% | 12% | 9% | 5% | 3% | 2% | 1% |
C | 8% | 20% | 28% | 19% | 13% | 6% | 3% | 2% | 1% |
D | 5% | 30% | 20% | 20% | 5% | 5% | 5% | 5% | 5% |
Claims (19)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2016113879 | 2016-12-30 | ||
CNPCT/CN2016/113879 | 2016-12-30 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN108283647A CN108283647A (zh) | 2018-07-17 |
CN108283647B true CN108283647B (zh) | 2021-01-15 |
Family
ID=62706915
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201711467596.6A Active CN108283647B (zh) | 2016-12-30 | 2017-12-28 | 甘露糖醛二酸的组合物 |
Country Status (14)
Country | Link |
---|---|
US (2) | US11384111B2 (zh) |
EP (1) | EP3563853A4 (zh) |
JP (1) | JP6977059B2 (zh) |
KR (1) | KR102539060B1 (zh) |
CN (1) | CN108283647B (zh) |
AU (1) | AU2017385332B2 (zh) |
BR (1) | BR112019013459A2 (zh) |
CA (1) | CA3048554C (zh) |
EA (1) | EA201991615A1 (zh) |
MA (1) | MA47179A (zh) |
MY (1) | MY192462A (zh) |
PH (1) | PH12019550107A1 (zh) |
UA (1) | UA127034C2 (zh) |
WO (1) | WO2018121559A1 (zh) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN110652525A (zh) | 2018-06-29 | 2020-01-07 | 上海绿谷制药有限公司 | 甘露糖醛二酸的组合物在治疗炎症中的应用 |
CN110652516A (zh) * | 2018-06-29 | 2020-01-07 | 上海绿谷制药有限公司 | 甘露糖醛二酸的组合物在治疗帕金森氏症中的应用 |
CN110652523A (zh) * | 2018-06-29 | 2020-01-07 | 上海绿谷制药有限公司 | 甘露糖醛二酸的组合物在治疗血管性痴呆症中的应用 |
CN110652517A (zh) * | 2018-06-29 | 2020-01-07 | 上海绿谷制药有限公司 | 褐藻胶寡糖二酸的组合物 |
CN110652526A (zh) * | 2018-06-29 | 2020-01-07 | 上海绿谷制药有限公司 | 甘露糖醛二酸的组合物在治疗糖尿病中的应用 |
CN112336876A (zh) * | 2019-08-06 | 2021-02-09 | 上海绿谷制药有限公司 | 用于识别阿尔茨海默病患者中的糖类药物敏感性患者的方法 |
CN112336742A (zh) * | 2019-08-06 | 2021-02-09 | 上海绿谷制药有限公司 | 甘露糖醛酸寡糖治疗Th1主导相关疾病的用途 |
CN112336860A (zh) * | 2019-08-06 | 2021-02-09 | 上海绿谷制药有限公司 | 通过调节肠道微生物治疗阿尔茨海默病的方法 |
CN112336861A (zh) * | 2019-08-06 | 2021-02-09 | 上海绿谷制药有限公司 | 通过调节氨基酸水平治疗阿尔茨海默病的方法 |
CN112741838A (zh) * | 2019-10-31 | 2021-05-04 | 上海绿谷制药有限公司 | 含有褐藻胶寡糖二酸的药用组合物 |
CN110755440B (zh) * | 2019-11-20 | 2023-02-28 | 中国海洋大学 | 川芎嗪和甘露糖醛酸的组合物在用于制备治疗血栓性疾病和神经系统疾病的药物中的应用 |
CN113244445A (zh) * | 2021-05-24 | 2021-08-13 | 广州市尚信净化工程有限公司 | 一种氧化亚铜-氧化刺槐豆胶抗菌凝胶 |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100508985C (zh) * | 2004-03-24 | 2009-07-08 | 中国海洋大学 | 褐藻胶寡糖及其衍生物及其制备方法和用途 |
CN106344595A (zh) * | 2015-07-17 | 2017-01-25 | 上海绿谷制药有限公司 | 褐藻胶寡糖及其衍生物在治疗疼痛中的应用 |
CN106349298A (zh) * | 2015-07-17 | 2017-01-25 | 上海绿谷制药有限公司 | 褐藻胶寡糖及其衍生物在改善睡眠障碍中的应用 |
CN106344594A (zh) * | 2015-07-17 | 2017-01-25 | 上海绿谷制药有限公司 | 褐藻胶寡糖及其衍生物在治疗炎症中的应用 |
CN106344593A (zh) * | 2015-07-17 | 2017-01-25 | 上海绿谷制药有限公司 | 褐藻胶寡糖及其衍生物在治疗血管性痴呆中的应用 |
CN106344592A (zh) * | 2015-07-17 | 2017-01-25 | 上海绿谷制药有限公司 | 还原端1位为羧基的甘露糖醛酸寡糖及其衍生物在治疗帕金森氏症中的应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1562050A (zh) | 2004-03-24 | 2005-01-12 | 中国海洋大学 | 褐藻酸寡糖在抗痴呆、抗糖尿病中的应用 |
JP2016108474A (ja) | 2014-12-08 | 2016-06-20 | 栄治 松村 | オリゴ糖の製造方法およびオリゴ糖 |
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2017
- 2017-12-27 UA UAA201908582A patent/UA127034C2/uk unknown
- 2017-12-27 CA CA3048554A patent/CA3048554C/en active Active
- 2017-12-27 MY MYPI2019003786A patent/MY192462A/en unknown
- 2017-12-27 EA EA201991615A patent/EA201991615A1/ru unknown
- 2017-12-27 KR KR1020197022102A patent/KR102539060B1/ko active IP Right Grant
- 2017-12-27 JP JP2019556407A patent/JP6977059B2/ja active Active
- 2017-12-27 BR BR112019013459A patent/BR112019013459A2/pt unknown
- 2017-12-27 AU AU2017385332A patent/AU2017385332B2/en active Active
- 2017-12-27 US US16/474,928 patent/US11384111B2/en active Active
- 2017-12-27 WO PCT/CN2017/118843 patent/WO2018121559A1/zh unknown
- 2017-12-27 MA MA047179A patent/MA47179A/fr unknown
- 2017-12-27 EP EP17888733.7A patent/EP3563853A4/en active Pending
- 2017-12-28 CN CN201711467596.6A patent/CN108283647B/zh active Active
-
2019
- 2019-06-27 PH PH12019550107A patent/PH12019550107A1/en unknown
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2022
- 2022-07-08 US US17/860,468 patent/US20220356202A1/en active Pending
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN100508985C (zh) * | 2004-03-24 | 2009-07-08 | 中国海洋大学 | 褐藻胶寡糖及其衍生物及其制备方法和用途 |
CN106344595A (zh) * | 2015-07-17 | 2017-01-25 | 上海绿谷制药有限公司 | 褐藻胶寡糖及其衍生物在治疗疼痛中的应用 |
CN106349298A (zh) * | 2015-07-17 | 2017-01-25 | 上海绿谷制药有限公司 | 褐藻胶寡糖及其衍生物在改善睡眠障碍中的应用 |
CN106344594A (zh) * | 2015-07-17 | 2017-01-25 | 上海绿谷制药有限公司 | 褐藻胶寡糖及其衍生物在治疗炎症中的应用 |
CN106344593A (zh) * | 2015-07-17 | 2017-01-25 | 上海绿谷制药有限公司 | 褐藻胶寡糖及其衍生物在治疗血管性痴呆中的应用 |
CN106344592A (zh) * | 2015-07-17 | 2017-01-25 | 上海绿谷制药有限公司 | 还原端1位为羧基的甘露糖醛酸寡糖及其衍生物在治疗帕金森氏症中的应用 |
Also Published As
Publication number | Publication date |
---|---|
WO2018121559A1 (zh) | 2018-07-05 |
US20220356202A1 (en) | 2022-11-10 |
NZ754947A (en) | 2021-03-26 |
BR112019013459A2 (pt) | 2019-12-31 |
KR102539060B1 (ko) | 2023-06-02 |
PH12019550107A1 (en) | 2020-06-01 |
UA127034C2 (uk) | 2023-03-22 |
CA3048554C (en) | 2022-11-29 |
EP3563853A4 (en) | 2021-01-06 |
AU2017385332A1 (en) | 2019-07-18 |
EA201991615A1 (ru) | 2019-12-30 |
EP3563853A8 (en) | 2020-06-17 |
CN108283647A (zh) | 2018-07-17 |
JP2020507619A (ja) | 2020-03-12 |
KR20190101420A (ko) | 2019-08-30 |
US11384111B2 (en) | 2022-07-12 |
JP6977059B2 (ja) | 2021-12-08 |
MY192462A (en) | 2022-08-22 |
CA3048554A1 (en) | 2018-07-05 |
AU2017385332B2 (en) | 2020-10-29 |
EP3563853A1 (en) | 2019-11-06 |
US20200385417A1 (en) | 2020-12-10 |
MA47179A (fr) | 2019-11-06 |
WO2018121559A8 (zh) | 2023-03-30 |
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Effective date of registration: 20190211 Address after: 201203 No. 421 Newton Road, Zhangjiang High-tech Park, Shanghai Applicant after: Shanghai Green Valley Pharmaceutical Co., Ltd. Applicant after: Shanghai Institute of Materia Medica, Chinese Academy of Sciences Address before: 201203 No. 421 Newton Road, Zhangjiang High-tech Park, Shanghai Applicant before: Shanghai Green Valley Pharmaceutical Co., Ltd. |
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Effective date of registration: 20220217 Address after: 201203 Room 203, part 102, building 6, No. 393-421, Newton Road, China (Shanghai) pilot Free Trade Zone, Pudong New Area, Shanghai Patentee after: Green Valley (Shanghai) Pharmaceutical Technology Co.,Ltd. Patentee after: Shanghai Institute of Materia Medica, Chinese Academy of Sciences Address before: 201203 No. 421 Newton Road, Zhangjiang High-tech Park, Shanghai Patentee before: SHANGHAI GREEN VALLEY PHARMACEUTICAL Co.,Ltd. Patentee before: Shanghai Institute of Materia Medica, Chinese Academy of Sciences |
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