CN108273027A - A kind of ointment for treating knee osteoarthritis - Google Patents

A kind of ointment for treating knee osteoarthritis Download PDF

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CN108273027A
CN108273027A CN201810280263.0A CN201810280263A CN108273027A CN 108273027 A CN108273027 A CN 108273027A CN 201810280263 A CN201810280263 A CN 201810280263A CN 108273027 A CN108273027 A CN 108273027A
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gamboge
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史兰
史栋梁
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    • A—HUMAN NECESSITIES
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/748—Oldenlandia or Hedyotis
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/758—Zanthoxylum, e.g. pricklyash
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels

Abstract

The purpose of the present invention is just to provide a kind of ointment for treating knee osteoarthritis, is made of following raw material：River radix aconiti agrestis, asarum, full worm, gamboge, Herba Hedyotidis Diffusae %, Sculellaria barbata, pawpaw, pericarpium zanthoxyli, rhizoma zingiberis, Chinese prickly ash, lopseed, caulis sinomenii, bush, radix cyathulae, centipede, Sodium Polyacrylate, crosslinked polyacrylate, aluminum glycinate, sodium hydroxide, glacial acetic acid, citric acid, pentanediol, hexylene glycol, glycerine, parahydroxyacet-ophenone and water processed are made；Prescription of the present invention is scientific and reasonable, and abundant raw material, preparation method is simple, easy to produce, convenient to take, securely and reliably, curative for effect, effect is good, it is without side-effects, effective for treating knee osteoarthritis, it is the innovation treated on knee osteoarthritis drug, there is good economic and social benefit.

Description

A kind of ointment for treating knee osteoarthritis
Technical field
The present invention relates to Chinese medicine, especially a kind of ointment for treating knee osteoarthritis.
Background technology
Osteoarthritis (O A) is a kind of with the denaturation of articular cartilage, destruction and joint margins, subchondral bone matter hyperplasia, pass The inflammatory of section inner tissue changes chronic, the degenerative arthritis disease being characterized.Due to heavy burden, knee joint osseous arthritis (KOA) clinically most commonly seen, it is more common in old women, risk factor has fat, knee wound and Meniscectomy etc..It is popular Disease learns display, more than its incidence 60 years old is 50% in China, 75 years old or more is 80%.
Modern medicine believes that, KOA is using articular cartilage degenerative change as core, in mechanics and biology collective effect Under, cartilage cell, extracellular matrix and subchondral bone three degradation are unbalance with synthesis of coupling, especially older, are nourished under cartilage Blood vessel number reduce, cartilage physicochemical property changes, chondromalacia, abrasion and structural damage, and secondary subchondral bone matter hyperplasia is soft Bone strips off, and then destruction of joint, deformity, ultimately causes knee-joint anatomy exception and dysfunction.
Traditional Chinese medicine thinks that KOA belongs to heumatism scope, also known as " strict section disease " " arthroncus of knee " etc..《Plain Questions numbness opinion》Cloud：" bone Endlessly, multiple sense is in heresy, and interior house is in kidney for numbness." " knee person's house of tendons, bend and stretch cannot, bowed and humped posture in walking, tendons being about to exhaust.”《Zhang Shi doctors are logical All pain doors》Cloud：" knee person, house of tendons, without having not because of liver kidney deficiency person, empty person's chill moisture attacks it." in the understanding of all multipair knee numbness, Think that its main pathology is " this impotence mark numbness, muscles and bones imbalance ", extent of disease covers knee joint peripheral tendon, ligament, synovial membrane, pass Condyle, cartilage, subchondral bone are muscles and bones with disease.It is " caused by liver and kidney deficiency, muscles and bones, which is lost, supports "；It is designated as the wet stasis of blood of chill, and numbness resistance is closed Section.
Mainly divide the drug therapy of knee osteoarthritis oral and local injection at present.Oral drugs mainly have：1. non-steroid Body anti-inflammatory agent：There is good anti-inflammatory analgesic action, but certain gastrointestinal symptom and hepatic and renal function is also caused to damage, influences blood platelet Function increases Cardia cevent；2. opioid drug：Although there is good analgesic effect, alleviate moderate and severe pain, There is dependence；3. Chondroprotective agents：Have the function of anti-inflammatory, analgesia, Saving cortilage cartilage, but lack generally acknowledged ideal medicament, General such as Glucosamine, diacerein drug effect is slower, and needs prolonged application.Topical remedy mainly has：1. sugared cortex Hormone to relieving pain, less exudation effect can, but hormone medicine analgesic while have certain damage to articular cartilage, no Suitable prolonged application；2. sodium hyaluronate can mitigate pain, increase range of motion, Saving cortilage cartilage.But class is perfused in this kind of joint Operation requires high when drug is to injection, once infection, damage is much larger than its disease itself.Though now there is treatment knee osteoarthritis Plurality of Chinese object, but for various reasons, using and curative effect and unsatisfactory, therefore, treat on knee osteoarthritis drug It is imperative to improve and innovate.
Invention content
For the above situation, to overcome the defect of the prior art, the purpose of the present invention, which is just to provide, a kind for the treatment of kneecap pass Scorching ointment is saved, can effectively solve the problems, such as the good medication for the treatment of knee osteoarthritis safe effect.
The technical solution that the present invention solves is the solidifying interpretation of the cause, onset and process of an illness of being trembled with fear according to the gonitis deficiency of yang, using dispelling cold dredging collateral as method, is controlled preferably " dispelling cold and removing dampness, temperature three-way meridian ", accordingly, a kind of ointment for treating knee osteoarthritis of the present invention, by following weight percent meter Raw material is made：River radix aconiti agrestis 0.66-0.76% processed, asarum 1.02-1.12%, full worm 1.02-1.12%, gamboge 1.38-1.48%, Herba Hedyotidis Diffusae 1.38-1.48%, Sculellaria barbata 1.38-1.48%, pawpaw 1.38-1.48%, pericarpium zanthoxyli 1.38-1.48%, rhizoma zingiberis 1.38-1.48%, Chinese prickly ash 1.38-1.48%, lopseed 1.38-1.48%, caulis sinomenii 1.38-1.48%, bush 1.38- 1.48%, radix cyathulae 2.0-3.0%, centipede 0.31-0.41%, Sodium Polyacrylate 4-6%, crosslinked polyacrylate 2-4%, sweet Propylhomoserin aluminium 0.05-0.15%, sodium hydroxide 0.03-0.13%, glacial acetic acid 0.15-0.25%, citric acid 0.05-0.15%, penta Glycol 1.5-2.5%, hexylene glycol 1.5-2.5%, glycerine 8-12%, parahydroxyacet-ophenone 0.5-1.5% and water 51-61% systems At；Wherein, above-mentioned glacial acetic acid, citric acid, parahydroxyacet-ophenone, hexylene glycol are added to the water, stir evenly to obtain A phases；It will be upper It states Sodium Polyacrylate, crosslinked polyacrylate, aluminum glycinate, sodium hydroxide to be added into pentanediol, glycerine, stirs evenly to obtain B Phase；By above-mentioned gamboge, oldenlandia diffusa, Sculellaria barbata, pawpaw, radix cyathulae, pericarpium zanthoxyli, rhizoma zingiberis, asarum, Chinese prickly ash, lopseed, river processed grass Crow, caulis sinomenii, bush, full worm, centipede are uniformly mixed to obtain C phases；C is added into B phases and is stirred evenly, the first jelly is obtained, First jelly is added in A phases and is stirred evenly, the second jelly is obtained,.
Prescription of the present invention is scientific and reasonable, and abundant raw material, preparation method is simple, easy to produce, convenient to take, securely and reliably, treats Effect is definite, and effect is good, without side-effects, effective for treating knee osteoarthritis, is the innovation treated on knee osteoarthritis drug, has Good economic and social benefit.
Specific implementation mode
It elaborates with reference to embodiments to the specific implementation mode of the present invention with concrete condition.
The present invention in the specific implementation, can be provided by following embodiment：
Embodiment 1：A kind of ointment for treating knee osteoarthritis is made of the raw material of following weight percent meter：River grass processed Black 0.68-0.74%, asarum 1.04-1.10%, full worm 1.04-1.10%, gamboge 1.40-1.46%, Herba Hedyotidis Diffusae 1.40- 1.46%, Sculellaria barbata 1.40-1.46%, pawpaw 1.40-1.46%, pericarpium zanthoxyli 1.40-1.46%, rhizoma zingiberis 1.40-1.46%, Chinese prickly ash 1.40-1.46%, lopseed 1.40-1.46%, caulis sinomenii 1.40-1.46%, bush 1.40-1.46%, radix cyathulae 2.2- 2.8%, centipede 0.33-0.39%, Sodium Polyacrylate 4.5-5.5%, crosslinked polyacrylate 2.5-3.5%, aluminum glycinate 0.07-0.13%, sodium hydroxide 0.05-0.11%, glacial acetic acid 0.17-0.23%, citric acid 0.07-0.13%, pentanediol 1.7-2.3%, hexylene glycol 1.7-2.3%, glycerine 9-11%, parahydroxyacet-ophenone 0.7-1.3% and water 53-59% are made；Its In, above-mentioned glacial acetic acid, citric acid, parahydroxyacet-ophenone, hexylene glycol are added to the water, A phases are stirred evenly to obtain；By above-mentioned poly- third Olefin(e) acid sodium, crosslinked polyacrylate, aluminum glycinate, sodium hydroxide are added into pentanediol, glycerine, stir evenly to obtain B phases；It will be upper State gamboge, oldenlandia diffusa, Sculellaria barbata, pawpaw, radix cyathulae, pericarpium zanthoxyli, rhizoma zingiberis, asarum, Chinese prickly ash, lopseed, river radix aconiti agrestis processed, green wind Rattan, bush, full worm, centipede are uniformly mixed to obtain C phases；C is added into B phases and is stirred evenly, the first jelly is obtained, by the first glue Shape object is added in A phases and stirs evenly, and obtains the second jelly,.
Embodiment 2：A kind of ointment for treating knee osteoarthritis is made of the raw material of following weight percent meter：River grass processed Crow 0.71%, asarum 1.07%, full worm 1.07%, gamboge 1.43%, Herba Hedyotidis Diffusae 1.43%, Sculellaria barbata 1.43%, pawpaw 1.43%, pericarpium zanthoxyli 1.43%, rhizoma zingiberis 1.43%, Chinese prickly ash 1.43%, lopseed 1.43%, caulis sinomenii 1.43%, bush 1.43%, Radix cyathulae 2.50%, centipede 0.36%, Sodium Polyacrylate 5%, crosslinked polyacrylate 3%, aluminum glycinate 0.1%, hydroxide Sodium 0.08%, glacial acetic acid 0.2%, citric acid 0.1%, pentanediol 2%, hexylene glycol 2%, glycerine 10%, parahydroxyacet-ophenone 1% It is made with water 56.51%；Wherein, above-mentioned glacial acetic acid, citric acid, parahydroxyacet-ophenone, hexylene glycol are added to the water, stirring is equal It is even to obtain A phases；Above-mentioned Sodium Polyacrylate, crosslinked polyacrylate, aluminum glycinate, sodium hydroxide are added into pentanediol, glycerine, Stir evenly to obtain B phases；By above-mentioned gamboge, oldenlandia diffusa, Sculellaria barbata, pawpaw, radix cyathulae, pericarpium zanthoxyli, rhizoma zingiberis, asarum, Chinese prickly ash, thoroughly Bone grass, river radix aconiti agrestis processed, caulis sinomenii, bush, full worm, centipede are uniformly mixed to obtain C phases；C is added into B phases and is stirred evenly, is obtained First jelly is added in A phases and stirs evenly, obtains the second jelly by the first jelly,.
Embodiment 3：A kind of ointment for treating knee osteoarthritis of the present invention, is made of the raw material of following weight percent meter： River radix aconiti agrestis 0.76% processed, asarum 1.12%, full worm 1.12%, gamboge 1.48%, Herba Hedyotidis Diffusae 1.48%, Sculellaria barbata 1.48%, pawpaw 1.48%, pericarpium zanthoxyli 1.48%, rhizoma zingiberis 1.48%, Chinese prickly ash 1.48%, lopseed 1.48%, caulis sinomenii 1.48%, Bush 1.48%, radix cyathulae 3.0%, centipede 0.41%, Sodium Polyacrylate 6%, crosslinked polyacrylate 4%, aluminum glycinate 0.15%, sodium hydroxide 0.13%, glacial acetic acid 0.25%, citric acid 0.15%, pentanediol 2.5%, hexylene glycol 2.5%, glycerine 12%, parahydroxyacet-ophenone 1.5% and water 61% are made；Wherein, by above-mentioned glacial acetic acid, citric acid, parahydroxyacet-ophenone, oneself two Alcohol is added to the water, and stirs evenly to obtain A phases；By above-mentioned Sodium Polyacrylate, crosslinked polyacrylate, aluminum glycinate, sodium hydroxide It is added into pentanediol, glycerine, stirs evenly to obtain B phases；By above-mentioned gamboge, oldenlandia diffusa, Sculellaria barbata, pawpaw, radix cyathulae, river Green pepper, rhizoma zingiberis, asarum, Chinese prickly ash, lopseed, river radix aconiti agrestis processed, caulis sinomenii, bush, full worm, centipede are uniformly mixed to obtain C phases；C is added Enter into B phases and stir evenly, obtain the first jelly, the first jelly is added in A phases and is stirred evenly, obtains the second jelly, i.e., At.
Embodiment 4：A kind of ointment for treating knee osteoarthritis of the present invention, is made of the raw material of following weight percent meter： River radix aconiti agrestis 0.66% processed, asarum 1.02%, full worm 1.02%, gamboge 1.38%, Herba Hedyotidis Diffusae 1.38%, Sculellaria barbata 1.38%, pawpaw 1.38%, pericarpium zanthoxyli 1.38%, rhizoma zingiberis 1.38%, Chinese prickly ash 1.38%, lopseed 1.38%, caulis sinomenii 1.38%, Bush 1.38%, radix cyathulae 2.0%, centipede 0.31%, Sodium Polyacrylate 4%, crosslinked polyacrylate 2%, aluminum glycinate 0.05%, sodium hydroxide 0.03%, glacial acetic acid 0.15%, citric acid 0.05%, pentanediol 1.5%, hexylene glycol 1.5%, glycerine 8%, parahydroxyacet-ophenone 0.5% and water 51% are made；Wherein, by above-mentioned glacial acetic acid, citric acid, parahydroxyacet-ophenone, oneself two Alcohol is added to the water, and stirs evenly to obtain A phases；By above-mentioned Sodium Polyacrylate, crosslinked polyacrylate, aluminum glycinate, sodium hydroxide It is added into pentanediol, glycerine, stirs evenly to obtain B phases；By above-mentioned gamboge, oldenlandia diffusa, Sculellaria barbata, pawpaw, radix cyathulae, river Green pepper, rhizoma zingiberis, asarum, Chinese prickly ash, lopseed, river radix aconiti agrestis processed, caulis sinomenii, bush, full worm, centipede are uniformly mixed to obtain C phases；C is added Enter into B phases and stir evenly, obtain the first jelly, the first jelly is added in A phases and is stirred evenly, obtains the second jelly, i.e., At.
In prescription of the present invention, wherein：
Gamboge：Acid；It is puckery；It is cool；It is toxic；The main detumescence of work(, detoxification, hemostasis, desinsection；《Detailed outline is picked up any lost article from the road》：" control ulcer, hemostasisization Poison holds back metal-inflicted wound, also can desinsection."
Oldenlandia diffusa：It is bitter, light, it is cold in nature；Primary efficacy is clearing heat and detoxicating, medicinal powder for relieving pain knot, promoting urination and removing dampness；《Quanzhou sheet Grass》：Heat-clearing dissipates the stasis of blood, the carbuncle that disappears removing toxic substances；Control ulcer sores, scrofula.
Sculellaria barbata：Acrid flavour, it is bitter, it is cold in nature；It is distributed in lung channel, Liver Channel, kidney channel；Work(master is clearing heat and detoxicating, dissipate stasis of blood hemostasis, inducing diuresis to remove edema； 《Quanzhou book on Chinese herbal medicine》：Heat-clearing, removing toxic substances, method wind dissipate blood, promoting the circulation of qi, Li Shui, dredging collateral, broken stasis of blood, analgesic；It takes main blood strangury orally, spits blood, bleeding from five sense organs or subcutaneous tissue； External application smelting venomous snake bite, ulcer, furunculosis, nameless sores or boils.
Pawpaw：It is warm-natured, it is sour；Return liver, the spleen channel；The main relaxing tendons and activating collaterals of work(, stomach dampness elimination；《Bencao Jingshu》：Lower part waist and knee without Power, since essence and blood is empty, kidney-KIN being deficient person should not use.Taste of getting ill from overeating are not empty, stagnate more persons, should not use.
Radix cyathulae：Sweet, slight bitter is put down；Return liver and kidney channel；The main dispelling stasis of blood and stimulating the menstrual flow of work(, easing joint movement, inducing diuresis for treating strangurtia；《Traditional Chinese Medicine in Sichuan Will》：Expelling wind and removing dampness, promoting menstruation dissipate blood；Control cold-dampness waist-leg ostalgia, sufficient impotence muscle contraction, women's Amenorrhea and the abdominal mass fiber crops root of bidentate achyranthes, gonorrhoea, hematuria, Impotence is lost and drowns.
Pericarpium zanthoxyli：It is pungent, warm, slightly poisonous, fiber crops；The main fragrant stomach invigorating of work(, warming spleen and stomach for dispelling cold, damp dispelling and pain relieving, desinsection removing toxic substances, antipruritic solution raw meat The effect of.
Rhizoma zingiberis：It is pungent, property heat, returns spleen, stomach, kidney channel, the main warming spleen and stomach for dispelling cold of work(, recover Yang and smooth venation；《Haigoushen》Cloud：It " controls in waist kidney Ache cold, cold air, wind is removed in blood-breaking, leads to extremities joint, opens the vital organs of the human body, go the cold numbness of wind toxin.”
Asarum：It is acrid in flavour and warm in nature；The thoughts of returning home, lung, kidney channel；The main relieving exterior syndrome and dispelling cold of work(, wind-expelling pain-stopping is sensible, warming lung and resolving fluid；《This warp》：It is main Cough is inverse, and headache brain is dynamic, hundred section contractions, arthralgia pain due to rheumatism, dead flesh；Improving eyesight, sharp nine orifices.
Chinese prickly ash：It is acrid in flavour and warm in nature；Returns spleen, stomach, kidney channel；The main warm in pain of work(, desinsection are antipruritic；《This warp》：Main ailment said due to cold or exposure gas, middle benefit gas are removed Arthritis, hard tooth hair, improving eyesight；Main perverse trend cough is inverse, middle benefit gas, by the dead flesh of joint skin, numbness and ache of cold dampness, lower gas.
Lopseed：It is pungent, bitter, temperature；It is slightly poisonous；Return liver and kidney channel；The main dispelling wind and eliminating dampness of work(, removing toxic substances analgesic；For rheumatoid arthrosis Bitterly；Sore swollen toxin is controlled in external application；《Detailed outline》：" control muscles and bones all rheumatalgia pain contractures, the disturbance of lower legs due to pathogenic cold and dampness."
River radix aconiti agrestis processed：Acrid flavour；It is warm-natured；It is toxic；Dispelling wind and eliminating dampness, cold dispelling dredging collateral.
Caulis sinomenii：It is bitter, pungent；Return liver, the spleen channel；The main wind-damp dispelling of work(, degrading the channel, diuresis；《Detailed outline》:Rheumatism streamer is controlled, Joint-running crane knee benumbs itch, damages sore swells, enters in yeast for brewing rice wine and use；《Tianmu Mountains of Zhejiang Province medicine plants will》:Lower burnt blood system is rushed down in row water diuresis It is damp and hot；Control edema caused by wind, tinea pedis, pain in rheumatoid joints, facial paralysis, Carbuncle swells dislikes sore.
Bush：It is sweet, salty, it puts down, the thoughts of returning home, liver, the spleen channel；The main promoting circulation of blood dissolving stasis of work(, swelling and pain relieving；For closed dysmenorrhea, the postpartum stasis of blood Resistance, chest and abdomen shouting pain, wound swelling and pain；《Japan hanako materia medica》:Apocenosis pain relieving, subduing inflammation flutter damage hemostasis, woman's aphonia, and blood is kept silent, red white Dysentery and after divide shoot.
Full worm：It is pungent, it puts down；It is toxic；Return liver warp.The main ceases wind antispastic of work(, dispersing pathogen accumulation are removed obstruction in channels to relieve pain；《Beautiful Chinese catalpa medicine solution》：It " wears Muscle is deep, and wind is removed by wet."
Centipede：It is acrid in flavour and warm in nature；It is toxic；Return liver warp；The main antispastic cramp and relieves dizziness of work(, work(poison dissipating bind, removes obstruction in channels to relieve pain；《Join west in medicine inner feelings Record》：" channels and collaterals apoplexy is controlled outside, facial paralysis is numb in every limb.”
Prescription of the present invention is using gamboge, oldenlandia diffusa, Sculellaria barbata, pawpaw as monarch drug in a prescription, subdhing swelling and detoxicating, dissipating bind dehumidifying；Pericarpium zanthoxyli, Rhizoma zingiberis, asarum, Chinese prickly ash, river radix aconiti agrestis processed are ministerial drug, and wind-dispelling cold-dampness is removed obstruction in channels to relieve pain；Full worm, centipede, lopseed, caulis sinomenii, bush For adjutant wind-dispelling cold-dampness is taken into account to remove obstruction in channels to relieve pain；Radix cyathulae is to make medicine, priming downlink, and with wind-damp dispelling eliminating impediment；Amount to " cold dispelling The benefits of dehumidifying, temperature three-way meridian ".
Prescription component science, reasonable compatibility support mutually, work well that curative effect is stablized, drug safety, and are provided through clinic Extraordinary advantageous effects have been arrived in material acquirement, and related clinical data is as follows：
(1) case selection
Choose the KOA patient accepted for medical treatment in January, 2016 in January, 2015-in institute of traditional Chinese medicine of Henan Province, totally 90, wherein man 32 Example, female 58；38~87 years old age, average (46.9 ± 5.8)；The course of disease 2 months~15 years, average (1.9 ± 0.5) year；Have not Gonalgia, limitation of activity medical history with degree；All patients are randomly divided into 2 groups；Treatment group 45, man 15, female 30； Average age (47.2 ± 6.1) year；Average course of disease (2.0 ± 0.6) year, constitutional index (B M I) 27.3 ± 4.6；Diseased region 24, single knee, 21, double knees；Control group 45, man 16, female 29；Average age (46.6 ± 7.7) year；Average course of disease (1.8 ± 0.5) year, B M I：26.9±4.5；23, diseased region list knee, 22, double knees；2 groups of general information compare, and difference is without statistics Meaning (P ＞ 0.05) is learned, is comparable.
(2) diagnostic criteria
With reference to nineteen ninety-five American society of rheumatism (AC R) about KOA classification diagnosis standards：1. frequent knee repeatedly in nearly January Arthralgia；2. having fricative when activity；3. knee joint morning stiffness≤30m in；4. person in middle and old age person >=40 year old；5. knee joint epiphysis Hypertrophy is with osteoproliferation；Meet 1.+2.+3.+4. item of item or 1.+2.+3.+5., diagnosable KOA.
Standards of Chinese Medical Syndrome Differentiation:Reference《New Chinese medicine guideline of clinical investigations》Dialectical is syndrome of yang deficiency and coagulated cold：Knee joint aches Pain acid weight, meet it is cold aggravate, obtain Wen Ze and subtract, knee joint swelling, it is stiff arrest tight, joint joint stuffiness, activity postemphasis, brothers are not Temperature, diarrhea with loose stool, clear abundant urine；Tongue vein:Pale tongue has indentation, and tongue is greasy, and deep thready pulse is puckery.
Inclusion criteria：1. meeting the clinical criteria of the knee osteoarthritis of nineteen ninety-five American society of rheumatism recommendation；② Meet《New Chinese medicine guideline of clinical investigations》The dialectical tcm diagnosis standard for syndrome of yang deficiency and coagulated cold；3. the age is 38~87 Year；4. signing informed consent form.
Exclusion criteria：1. the diseases such as rheumatism relevant disease, connective tissue disease, tumour lead to gonitis lesion person；② Joint serious degenerative person, joint space Serious Stenosis and bony ankylosis person；3. allergic constitution person, training and curative compliance are poor Person；4. merging apparent cardiovascular and cerebrovascular disease and mental disease needs curer.
(3) therapeutic scheme
Control group gives Flurbiprofen gel emplastrum (Zepu is thought, Chinese medicines quasi-word H20160288)：2 times a day, it is affixed on trouble Knee, using 15 days.
Ointment external application of the present invention is given by treatment group, once a day, external application, using 15 days.
Equal follow-up January after two groups of patient's treatments.
(4) main observation index and efficacy evaluation
1. symptom and sign is evaluated：It is scored using the standards of grading Lequesne indexes of international osteoarthritis, including knee Joint rest pain, motion pain, tenderness, swelling, morning stiffness, locomotor activity；
2. clinical efficacy is evaluated；Reference《New Chinese medicine guideline of clinical investigations (tentative)》It drafts.Clinical recovery：Chinese medicine Clinical symptoms, sign disappear or mostly disappear, syndrome integral reduce >=95%；It is effective：Tcm clinical practice symptom, sign obviously change Kind, 70%≤syndrome integral reduces ＜ 95%；Effectively：Tcm clinical practice symptom, sign take a favorable turn, and 30%≤syndrome integral is reduced ＜ 70%.In vain：Tcm clinical practice symptom, sign are not improved, even aggravating, syndrome integral reduces ＜ 30%.Note：It calculates Formula：[(being integrated when prior treatment integral-treatment end)/prior treatment integral] × 100%.
(5) statistical procedures
Statistical procedures carry out Data Management Analysis using SPSS18.0；Measurement data is indicated with (± s), in two sample groups Using paired t-test, independent samples t-test is used between group；Enumeration data uses χ2It examines.
Curative effect compares and (is shown in Table 1) after 2 groups of treatments and when last follow-up；Treatment group's total effective rate 97.8% after treatment, control Group total effective rate 75.6%, 2 groups of curative effects compare with significant difference (P<0.05), treatment group's curative effect is better than control group；Last Treatment group's total effective rate 97.8% when follow-up, control group total effective rate 75.6%, 2 groups of curative effects compare with significant difference (P< 0.05), treatment group's curative effect is better than control group.
12 groups of patient's curative effects of table compare
Note：After treatment, compared with the control group, 1. P<0.05；In treatment group, when last follow-up compared with, 2. P>0.05；End When secondary follow-up, compared with the control group, 3. P<0.05.
2 groups of pretherapy and post-treatment clinical indexes results contrasts (being shown in Table 2)；2 groups of each item ratings are bright before relatively treating after treatment It is aobvious to decline (P<0.05), and each item rating for the treatment of group declines compared with control group significantly (P<0.05).
The pretherapy and post-treatment observation index scoring of 22 groups of table is compared (± s)
Note：Compare in two groups of groups, 1. P<0.01；Comparison among groups, compared with after control group treatment, 2. P<0.05
Conclusion
The present invention is applied to merely part, and in clinical observation and finds no the generations of the adverse reactions such as allergy, avoids The infection risk of corresponding adverse reaction caused by the absorption of gastrointestinal tract and local joint perfusion, observes through clinical application and finds to treat Effect is notable, eliminates Small side effects, easy to use, has actual clinical meaning.
Instant component is scientific and reasonable, and dosage is safe and effective, effective for treating knee osteoarthritis, good effect, medication peace Entirely, it has no toxic side effect, curative effect is high, and total effective rate is up to 97.8%, is the big innovation treated on knee osteoarthritis drug, has good Good economic and social benefit.

Claims (5)

1. a kind of ointment for treating knee osteoarthritis, it is characterized in that：It is made of the raw material of following weight percent meter：River radix aconiti agrestis processed 0.66-0.76%, asarum 1.02-1.12%, full worm 1.02-1.12%, gamboge 1.38-1.48%, Herba Hedyotidis Diffusae 1.38-1.48%, Sculellaria barbata 1.38-1.48%, pawpaw 1.38-1.48%, pericarpium zanthoxyli 1.38-1.48%, rhizoma zingiberis 1.38-1.48%, Chinese prickly ash 1.38-1.48%, Lopseed 1.38-1.48%, caulis sinomenii 1.38-1.48%, bush 1.38-1.48%, radix cyathulae 2.0-3.0%, centipede 0.31- 0.41%, Sodium Polyacrylate 4-6%, crosslinked polyacrylate 2-4%, aluminum glycinate 0.05-0.15%, sodium hydroxide 0.03- 0.13%, glacial acetic acid 0.15-0.25%, citric acid 0.05-0.15%, pentanediol 1.5-2.5%, hexylene glycol 1.5-2.5%, glycerine 8- 12%, parahydroxyacet-ophenone 0.5-1.5% and water 51-61% are made；Wherein, by above-mentioned glacial acetic acid, citric acid, parahydroxyacet-ophenone, Hexylene glycol is added to the water, and stirs evenly to obtain A phases；By above-mentioned Sodium Polyacrylate, crosslinked polyacrylate, aluminum glycinate, hydrogen-oxygen Change sodium to be added into pentanediol, glycerine, stirs evenly to obtain B phases；By above-mentioned gamboge, oldenlandia diffusa, Sculellaria barbata, pawpaw, river ox Knee, pericarpium zanthoxyli, rhizoma zingiberis, asarum, Chinese prickly ash, lopseed, river radix aconiti agrestis processed, caulis sinomenii, bush, full worm, centipede are uniformly mixed to obtain C phases；By C It is added into B phases and stirs evenly, obtain the first jelly, the first jelly is added in A phases and is stirred evenly, obtain the second glue Object,.
2. the ointment for the treatment of knee osteoarthritis according to claim 1, it is characterized in that：By the original of following weight percent meter Material is made：River radix aconiti agrestis 0.68-0.74% processed, asarum 1.04-1.10%, full worm 1.04-1.10%, gamboge 1.40-1.46%, all sorts of flowers snake Tongue grass 1.40-1.46%, Sculellaria barbata 1.40-1.46%, pawpaw 1.40-1.46%, pericarpium zanthoxyli 1.40-1.46%, rhizoma zingiberis 1.40-1.46%, Chinese prickly ash 1.40-1.46%, lopseed 1.40-1.46%, caulis sinomenii 1.40-1.46%, bush 1.40-1.46%, radix cyathulae 2.2- 2.8%, centipede 0.33-0.39%, Sodium Polyacrylate 4.5-5.5%, crosslinked polyacrylate 2.5-3.5%, aluminum glycinate 0.07- 0.13%, sodium hydroxide 0.05-0.11%, glacial acetic acid 0.17-0.23%, citric acid 0.07-0.13%, pentanediol 1.7-2.3%, oneself Glycol 1.7-2.3%, glycerine 9-11%, parahydroxyacet-ophenone 0.7-1.3% and water 53-59% are made；Wherein, by above-mentioned glacial acetic acid, Citric acid, parahydroxyacet-ophenone, hexylene glycol are added to the water, and stir evenly to obtain A phases；By above-mentioned Sodium Polyacrylate, crosslinked polypropylene Olefin(e) acid ester, aluminum glycinate, sodium hydroxide are added into pentanediol, glycerine, stir evenly to obtain B phases；By above-mentioned gamboge, oldenlandia Grass, Sculellaria barbata, pawpaw, radix cyathulae, pericarpium zanthoxyli, rhizoma zingiberis, asarum, Chinese prickly ash, lopseed, river radix aconiti agrestis processed, caulis sinomenii, bush, full worm, Wu Centipede is uniformly mixed to obtain C phases；C is added into B phases and is stirred evenly, the first jelly is obtained, the first jelly is added in A phases and is stirred It mixes uniformly, obtains the second jelly,.
3. the ointment for the treatment of knee osteoarthritis according to claim 1, it is characterized in that：By the original of following weight percent meter Material is made：River radix aconiti agrestis 0.71% processed, asarum 1.07%, full worm 1.07%, gamboge 1.43%, Herba Hedyotidis Diffusae 1.43%, Sculellaria barbata 1.43%, pawpaw 1.43%, pericarpium zanthoxyli 1.43%, rhizoma zingiberis 1.43%, Chinese prickly ash 1.43%, lopseed 1.43%, caulis sinomenii 1.43%, bush 1.43%, radix cyathulae 2.50%, centipede 0.36%, Sodium Polyacrylate 5%, crosslinked polyacrylate 3%, aluminum glycinate 0.1%, hydroxide Sodium 0.08%, glacial acetic acid 0.2%, citric acid 0.1%, pentanediol 2%, hexylene glycol 2%, glycerine 10%, parahydroxyacet-ophenone 1% and water 56.51% is made；Wherein, above-mentioned glacial acetic acid, citric acid, parahydroxyacet-ophenone, hexylene glycol are added to the water, stir evenly to obtain A Phase；Above-mentioned Sodium Polyacrylate, crosslinked polyacrylate, aluminum glycinate, sodium hydroxide are added into pentanediol, glycerine, stirred It is uniform to obtain B phases；By above-mentioned gamboge, oldenlandia diffusa, Sculellaria barbata, pawpaw, radix cyathulae, pericarpium zanthoxyli, rhizoma zingiberis, asarum, Chinese prickly ash, deep Grass, river radix aconiti agrestis processed, caulis sinomenii, bush, full worm, centipede are uniformly mixed to obtain C phases；C is added into B phases and is stirred evenly, obtains First jelly is added in A phases and stirs evenly, obtains the second jelly by one jelly,.
4. the ointment for the treatment of knee osteoarthritis according to claim 1, it is characterized in that：By the original of following weight percent meter Material is made：River radix aconiti agrestis 0.76% processed, asarum 1.12%, full worm 1.12%, gamboge 1.48%, Herba Hedyotidis Diffusae 1.48%, Sculellaria barbata 1.48%, pawpaw 1.48%, pericarpium zanthoxyli 1.48%, rhizoma zingiberis 1.48%, Chinese prickly ash 1.48%, lopseed 1.48%, caulis sinomenii 1.48%, bush 1.48%, radix cyathulae 3.0%, centipede 0.41%, Sodium Polyacrylate 6%, crosslinked polyacrylate 4%, aluminum glycinate 0.15%, hydroxide Sodium 0.13%, glacial acetic acid 0.25%, citric acid 0.15%, pentanediol 2.5%, hexylene glycol 2.5%, glycerine 12%, parahydroxyacet-ophenone 1.5% and water 61% be made；Wherein, above-mentioned glacial acetic acid, citric acid, parahydroxyacet-ophenone, hexylene glycol are added to the water, stirring is equal It is even to obtain A phases；Above-mentioned Sodium Polyacrylate, crosslinked polyacrylate, aluminum glycinate, sodium hydroxide are added into pentanediol, glycerine, Stir evenly to obtain B phases；By above-mentioned gamboge, oldenlandia diffusa, Sculellaria barbata, pawpaw, radix cyathulae, pericarpium zanthoxyli, rhizoma zingiberis, asarum, Chinese prickly ash, thoroughly Bone grass, river radix aconiti agrestis processed, caulis sinomenii, bush, full worm, centipede are uniformly mixed to obtain C phases；C is added into B phases and is stirred evenly, is obtained First jelly is added in A phases and stirs evenly, obtains the second jelly by the first jelly,.
5. the ointment for the treatment of knee osteoarthritis according to claim 1, it is characterized in that：By the original of following weight percent meter Material is made：River radix aconiti agrestis 0.66% processed, asarum 1.02%, full worm 1.02%, gamboge 1.38%, Herba Hedyotidis Diffusae 1.38%, Sculellaria barbata 1.38%, pawpaw 1.38%, pericarpium zanthoxyli 1.38%, rhizoma zingiberis 1.38%, Chinese prickly ash 1.38%, lopseed 1.38%, caulis sinomenii 1.38%, bush 1.38%, radix cyathulae 2.0%, centipede 0.31%, Sodium Polyacrylate 4%, crosslinked polyacrylate 2%, aluminum glycinate 0.05%, hydroxide Sodium 0.03%, glacial acetic acid 0.15%, citric acid 0.05%, pentanediol 1.5%, hexylene glycol 1.5%, glycerine 8%, parahydroxyacet-ophenone 0.5% It is made with water 51%；Wherein, above-mentioned glacial acetic acid, citric acid, parahydroxyacet-ophenone, hexylene glycol are added to the water, are stirred evenly A phases；Above-mentioned Sodium Polyacrylate, crosslinked polyacrylate, aluminum glycinate, sodium hydroxide are added into pentanediol, glycerine, stirred It is uniform to obtain B phases；By above-mentioned gamboge, oldenlandia diffusa, Sculellaria barbata, pawpaw, radix cyathulae, pericarpium zanthoxyli, rhizoma zingiberis, asarum, Chinese prickly ash, deep Grass, river radix aconiti agrestis processed, caulis sinomenii, bush, full worm, centipede are uniformly mixed to obtain C phases；C is added into B phases and is stirred evenly, obtains First jelly is added in A phases and stirs evenly, obtains the second jelly by one jelly,.
CN201810280263.0A 2018-04-02 2018-04-02 A kind of ointment for treating knee osteoarthritis Pending CN108273027A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050019436A1 (en) * 2002-12-18 2005-01-27 Algorx Injectable capsaicin
CN106039271A (en) * 2016-07-26 2016-10-26 河南中医学院 Plaster for treating knee osteoarthritis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050019436A1 (en) * 2002-12-18 2005-01-27 Algorx Injectable capsaicin
CN106039271A (en) * 2016-07-26 2016-10-26 河南中医学院 Plaster for treating knee osteoarthritis

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Application publication date: 20180713