CN108272654A - A kind of cooling aerosol disinfectant composition and aerosol products - Google Patents
A kind of cooling aerosol disinfectant composition and aerosol products Download PDFInfo
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- CN108272654A CN108272654A CN201810136926.1A CN201810136926A CN108272654A CN 108272654 A CN108272654 A CN 108272654A CN 201810136926 A CN201810136926 A CN 201810136926A CN 108272654 A CN108272654 A CN 108272654A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/731—Cellulose; Quaternized cellulose derivatives
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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- A61K2800/413—Nanosized, i.e. having sizes below 100 nm
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- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/48—Thickener, Thickening system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
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Abstract
The invention belongs to cosmetic fields, and in particular to a kind of cooling aerosol disinfectant composition and aerosol products, the aerosol combination include following raw material and its mass fraction：Propellant 40 80%, pure water 10 50%, absolute ethyl alcohol 0.1 10%, excipient 0.31 1.3% and fungicide 0.001 0.02%.The present composition is stable, safe and non-stimulating, and aerosol products are easy to carry, easy to operate, can also kill bacterium while quickly reducing human skin temperature, skin bacterium is inhibited to grow.
Description
Technical field
The invention belongs to cosmetic fields, and in particular to a kind of cooling aerosol disinfectant composition and aerosol products.
Background technology
These types of cool-down method is generally used when in face of heat condition：It drinks water, the scouring of wet towel, alcohol, ice cube, bring down a fever
Patch, hospital's medical treatment etc., at home and abroad society, market are very universal for this.But this is all the medical demand of human body fever, removes this
In addition, in daily life, there are many case where needing cooling, such as relieve summer heat in heat season lowering temperature, red and swollen scald needs ice compress etc..But
The outdoor more difficult acquisition of ice, and be difficult to carry, therefore there is an urgent need to a kind of cooling products easy to carry, easy to operate.
Chinese patent application CN102670421A discloses a kind of refrigerant aerosol of cooling composition of use in personal care, including
Propellant, water and ethyl alcohol；Further include excipient, emollient, moisturizer, menthol and annular siloxane, while also disclosing that one
Aerosol products of the kind containing above-mentioned composition.The invention can cool down rapidly, can be used for personal nursing, and aerosol products are taken
Band, it is easy to use, but the invention be solid, liquids and gases mixture, be long placed in will appear solid silica sedimentation, peppermint
The unstable problems of contents such as brain precipitation, and the invention only has simple cooling function, and do not have sterilizing function, drop
Skin surface moistening is easy to grow bacterium after temperature, influences skin health.
Various bacteria is carried on human normal skin, skin resident bacteria and skin transient bacterium can be divided into.The former refers to can be
Skin growths are bred, including staphylococcus epidermis etc.；The latter, which points to, falls within skin, can disappear from skin by certain time
It loses, including staphylococcus aureus, streptococcus etc..And bacterium and dermopathic relationship are very close, bacterium and its toxin can divide
Do not cause infection (such as furuncle), Poisoning lesion (such as staphylococcal scalded skin syndrome) and immune mediating lesion
(such as super antigen induces or aggravate atopic dermatitis, psoriasis), if do not paid attention to nursing, easy tos produce various skin problems, example
As the proliferation of facial bacterium is likely to result in acne class skin problem.
MontfortA.Johnsen exists《Skin nursing aerosol (II) --- remove pulvis, sterilization and skin conditioning product》
In disclose a kind of formula of skin nursing aerosol, including deionized water, carbopol, sodium nitrite, propylene glycol, imidazolidinyl
Urea, triethanolamine, butoxylated hydroxyanisole, Unitina BW, ricinoleic acid, alkoxy ether-ether, lightweight dormant oil, spermaceti
Alcohol, three pressure palmitic acids, essence and oxidation imido.The formula is particularly advantageous to there is the people of acne problems, as excellent depth skin
Skin detergent fully removes skin dirt, moreover it is possible to kill skin surface bacterium, while keep skin Hydrolyzed Protein, moisturizing, silk sample soft and smooth
Sense.But wherein carbopol contact skin can lead to skin irritatin, not accommodate dermexanthesis；Excessive nitrite sodium can be carcinogenic；Imidazolidinyl
Urea pollutes environment, etc., and many components are all poisonous and harmful in the formula, are not suitable for long-term use, and also do not meet sustainable development
Theory.
In view of the above-mentioned problems, it is necessary to provide a kind of cooling aerosol disinfectant composition and aerosol products, the aerosol
Composition is stable, safe and non-stimulating, and aerosol products are easy to carry, easy to operate, while quickly reducing human skin temperature
Bacterium can also be killed, skin bacterium is inhibited to grow.
Invention content
The present invention is intended to provide a kind of cooling aerosol disinfectant composition and aerosol products, the aerosol combination are steady
Calmly, ethanol content is low, and safe and non-stimulating, aerosol products are easy to carry, easy to operate, quickly reduces the same of human skin temperature
When can also kill bacterium, inhibit skin bacterium to grow.
In order to achieve the above object, the present invention uses following technical scheme：
A kind of cooling aerosol disinfectant composition and aerosol products, including following raw material and its mass fraction：Propellant
40-80%, pure water 10-50%, absolute ethyl alcohol 0.1-10%, excipient 0.31-1.3% and fungicide 0.001-0.02%.
Further, the propellant is selected from dimethyl ether, liquefied petroleum gas, HFC-152a, HFC-134a and HFO-
At least one of 1234ze.
Further, the fungicide is o-phenyl phenol.
Further, the excipient by hydroxyethyl cellulose, Sodium Caseinate and modified manometer silicon dioxide with weight ratio
(1-5):(1-5):(1-10) is formed.
Further, the preparation method of the modified manometer silicon dioxide is：
Nano silicon dioxide is put into absolute ethyl alcohol, ultrasonic disperse 30min is carried out, obtains system A；System A is placed in
In reaction kettle, 200-300 DEG C of temperature is set, pressure 15-30MPa reacts 2-6h, obtains modified manometer silicon dioxide.
Further, the aerosol combination further includes emollient, and the mass fraction of the emollient is 0.045-
0.36%；The one kind or more of the emollient in isopropyl myristate, isomery dodecane, glycerine and 1,3 butylene glycol
Kind.
Further, the aerosol combination further includes menthol, and the mass fraction of the menthol is 0.02-
0.22%.
Further, the aerosol combination further includes annular siloxane, and the mass fraction of the annular siloxane is
0.001-0.02%.
Further, the aerosol combination further includes aromatic, and the aromatic is p- anisic acids, quality point
Number is 0.01-0.15%.
In addition, the present invention also provides a kind of cooling aerosol disinfectant product, which includes above-mentioned cooling
Aerosol disinfectant composition and inhalator jar for canned the composition, the inhalator jar are equipped with 360 ° of valves, can just, stand upside down
Injection；
It is described cooling aerosol disinfectant product preparation method be：
S1, oil phase and water phase are prepared respectively, oil phase, which is then mixed with water conjunction stirring homogeneous, becomes lotion；
S2, lotion obtained by step S1 is poured into inhalator jar, fills valve, sealing fills propellant, and water-bath fills nozzle, dress
Outer cover, vanning.
Silica can avoid the precipitation of menthol as excipient as the carrier of menthol isoreactivity ingredient, but
Silica is solid, and sedimentation is easy in oil phase and the mixture of water phase, influences composition stability.Selection grain size is small, compares
After ethanol modifier, particle surface energy reduces the big nano silicon dioxide of surface area, has lipophilicity, can be born in oil phase
More active materials are carried, are conducive to spray together with propellant, but its grain size is small, is easy to reunite, be not easy in the mixture point
It dissipates, is long placed in and also will produce precipitation.
Sodium Caseinate is a kind of food additives, and the Sorbet shape composition formed after ejection can be made soft, fitted closely
Skin or article surface, meanwhile, applicants have unexpectedly found that, Sodium Caseinate can reduce the reunion of modified manometer silicon dioxide,
The state for making it tend to dispersion in the mixture, stablize.Experiment proves that aerosol of the present invention is stored 8 weeks at 50 ± 2 DEG C
Afterwards, smell, appearance and phase maintain a good state, and stability is good.And it is added without Sodium Caseinate, it stores up under the same conditions
It hides, there have been a small amount of precipitations within the 4th week.This illustrates that Sodium Caseinate can make modified manometer silicon dioxide stabilization, dispersion, ensures
Its menthol loaded is not precipitated, and keeps fragrance, content is made to stablize.Hydroxyethyl cellulose be a kind of water-soluble emulsifier,
Thickener and stabilizer, water holding capacity is high, has good flow adjustment, and component can be made to be uniformly mixed, and is formed and is stablized
Suspended liquid mixture.
P- anisic acids are a kind of natural, multi-functional perfume ingredients, and are not specified as preservative list.In addition to
As aromatic, P- anisic acids also have certain biocidal efficacies, and sterilizing mechanisms are：It, can electricity after infiltrating through cell membrane
H+ is separated out, the acid-base balance in cell liquid is broken, cell is made to suck the Na+ in water, in the process cell consumption energy, carefully
The pH of intracellular cell liquid can be reduced constantly, eventually led to thalline death, in the presence of Sodium Caseinate, can be promoted p- anisic acids
Permeation cell film, significantly improves bactericidal effect, the appropriate additive amount for reducing o-phenyl phenol.
The present invention has the following advantages：
(1) the maximum feature of the present invention is that ethanol content reduces 50% or more than existing spray, to people
Body irritation is small, and each component can keep uniformly mixing in system, and stability is high,
(2) invention can be directly injected into skin surface, and cooling while can inhibit bacterial growth breeding, prevent skin disease,
And it is easy to carry about with one, is easy to use.
Specific implementation mode
The specific implementation mode of form by the following examples makees further specifically the above of the present invention
It is bright.But the range that this should not be interpreted as to the above-mentioned theme of the present invention is only limitted to following embodiment.
HFC-152a is 1,1- Difluoroethanes, and HFC-134a is HFA 134a, HFO-1234ze 1,3,3,
3- tetrafluoropropenes are purchased from three Ai Fuzhonghao new chemical materials Co., Ltds；Remaining component is those skilled in the art of the present technique
Well known known substance, each component title are the titles of academicly specification.
The present invention is specifically described with reference to embodiments.
The preparation of modified manometer silicon dioxide：Nano silicon dioxide is put into ethyl alcohol, ultrasonic disperse 30min is carried out, obtains
To system A；System A is placed in reaction kettle, 250 DEG C, pressure 22MPa of temperature is set, 4h is reacted, obtains modified nano-silica
Silicon.
A kind of 1 cooling aerosol disinfectant composition of embodiment and aerosol products
1 embodiment of table, 1 each component and its mass fraction
Preparation method：
S1, hydroxyethyl cellulose and Sodium Caseinate are dissolved in pure water, mixture A is made；By modified nano-silica
Silicon, menthol, glycerine, isopropyl myristate, p- anisic acids, isomery dodecane, o-phenyl phenol and annular siloxane dissolving
It is dispersed in absolute ethyl alcohol, mixture B is made；A and B is mixed, homogeneous becomes lotion；
S2, lotion is poured into inhalator jar, fills valve, sealing fills propellant, and water-bath fills nozzle, fills outer cover, vanning.
A kind of 2 cooling aerosol disinfectant composition of embodiment and aerosol products
2 embodiment of table, 2 each component and its mass fraction
| Ingredient names | Mass fraction (%, w/w) |
| 1,1,1,2- tetrafluoroethane | 78.000 |
| Pure water | 17.200 |
| Absolute ethyl alcohol | 3.200 |
| Hydroxyethyl cellulose | 0.200 |
| Modified manometer silicon dioxide | 1.000 |
| Sodium Caseinate | 0.200 |
| Menthol | 0.020 |
| Isopropyl myristate | 0.010 |
| 1,3 butylene glycol | 0.070 |
| P- anisic acids | 0.010 |
| O-phenyl phenol | 0.015 |
| Isomery dodecane | 0.015 |
| Annular siloxane | 0.015 |
Preparation method：
S1, hydroxyethyl cellulose, 1,3-BDO and Sodium Caseinate are dissolved in pure water, mixture A is made；It will be modified
Nano silicon dioxide, menthol, isopropyl myristate, p- anisic acids, isomery dodecane, o-phenyl phenol and annular siloxane
Dissolving is dispersed in absolute ethyl alcohol, and mixture B is made；A and B is mixed, homogeneous becomes lotion；
S2, lotion is poured into inhalator jar, fills valve, sealing fills propellant, and water-bath fills nozzle, fills outer cover, vanning.
A kind of 3 cooling aerosol disinfectant composition of embodiment and aerosol products
3 embodiment of table, 3 each component and its mass fraction
| Ingredient names | Mass fraction (%, w/w) |
| Medical grade dimethyl ether | 60.000 |
| 1,1,1,2- tetrafluoroethane | 18.000 |
| Pure water | 17.200 |
| Absolute ethyl alcohol | 4.330 |
| Hydroxyethyl cellulose | 0.100 |
| Modified manometer silicon dioxide | 0.100 |
| Sodium Caseinate | 0.100 |
| Glycerine | 0.070 |
| O-phenyl phenol | 0.015 |
| Menthol | 0.020 |
| Isopropyl myristate | 0.020 |
| P- anisic acids | 0.020 |
| Isomery dodecane | 0.015 |
| Annular siloxane | 0.010 |
Preparation method：
S1, hydroxyethyl cellulose and Sodium Caseinate are dissolved in pure water, mixture A is made；By modified nano-silica
Silicon, menthol, glycerine, isopropyl myristate, p- anisic acids, isomery dodecane, o-phenyl phenol and annular siloxane dissolving
It is dispersed in absolute ethyl alcohol, mixture B is made；A and B is mixed, homogeneous becomes lotion；
S2, lotion is poured into inhalator jar, fills valve, sealing fills propellant, and water-bath fills nozzle, fills outer cover, vanning.
A kind of 4 cooling aerosol disinfectant composition of embodiment and aerosol products
4 embodiment of table, 4 each component and its mass fraction
| Ingredient names | Mass fraction (%, w/w) |
| HFO-1234ze | 66.800 |
| Pure water | 24.000 |
| Absolute ethyl alcohol | 7.100 |
| Hydroxyethyl cellulose | 0.250 |
| Modified manometer silicon dioxide | 1.500 |
| Sodium Caseinate | 0.200 |
| O-phenyl phenol | 0.010 |
| 1,3 butylene glycol | 0.070 |
| Menthol | 0.020 |
| Isopropyl myristate | 0.020 |
| P- anisic acids | 0.010 |
| Isomery dodecane | 0.010 |
| Annular siloxane | 0.010 |
Preparation method：
S1, hydroxyethyl cellulose, 1,3-BDO and Sodium Caseinate are dissolved in pure water, mixture A is made；It will be modified
Nano silicon dioxide, menthol, isopropyl myristate, p- anisic acids, isomery dodecane, o-phenyl phenol and annular siloxane
Dissolving is dispersed in absolute ethyl alcohol, and mixture B is made；A and B is mixed, homogeneous becomes lotion；
S2, lotion is poured into inhalator jar, fills valve, sealing fills propellant, and water-bath fills nozzle, fills outer cover, vanning.
A kind of 1 cooling aerosol disinfectant composition of comparative example and aerosol products
Comparative example 1 and embodiment 1 difference lies in, Sodium Caseinate is replaced with sorbitol anhydride laurate by comparative example 1,
Remaining operation and parameter reference embodiment 1.
A kind of refrigerant aerosol of cooling composition of comparative example 2 and aerosol products
Difference lies in comparative example 2 does not add Sodium Caseinate to comparative example 2, increases containing for hydroxyethyl cellulose with embodiment 1
Amount keeps amount of excipient same as Example 1, remaining operation and parameter reference embodiment 1.
A kind of refrigerant aerosol of cooling composition of comparative example 3 and aerosol products
Comparative example 3 and embodiment 1 difference lies in, modified manometer silicon dioxide is changed to silica by comparative example 3, remaining
Operation and parameter reference embodiment 1.
1 aerosol cooling-down effect of test example is tested
1. subjects：Embodiment 1-4 prepared inhalation aerosols.
2. test method：
A. under standard test condition, with 500mL band plugs triangular flask, ((thermometer is put in rubber plug trepanning), first puts thermometer
Entering constant temperature in triangular flask and 10g then is sprayed at sample alignment triangular flask bottom, then cover bottle stopper to 30 DEG C, thermometer will be inserted into bottom of bottle,
After 2min, thermometer is read, and record, finally observes thermometer temperature and decline range.
B. it is put into a stacker towel (about 1mm is thick) at band plug triangular flask bottom, repeated the above process.
3. test result：
A：There is one layer of very thin crystal mass in bottom of bottle, and it is more than 25 DEG C that embodiment 1-4, which reduces bottom of bottle surface temperature,.
B：Paper handkerchief surface is slightly hardened, and feeling has tied ice on paper handkerchief, feels dry, ice-cold.Embodiment 1-4 paper handkerchief tables
Face temperature is reduced more than 25 DEG C.
The above experimental result illustrates that aerosol provided by the invention has excellent cooling-down effect.
2 aerosol content skin irritatin performance of test example is tested
1. test material：Aerosol combination prepared by embodiment 1-4.
2. subjects：Choose healthy rabbit 80, weight 180-220g.
3. test method：Test method refers to《Cosmetics health specification》Skin irritation/the corrosivity of (version in 2007)
Experiment compares as the other side normal skin of same test animal, and standards of grading are shown in Table 5.
5 skin wound repair of table scores
4. test result：
6 Skin Irritation Test result of table
As can be seen from Table 6, in the observation period, the tested new zealand rabbit skins of embodiment 1-4 have no that erythema, oedema etc. are abnormal
Reaction, does not find other poisoning symptoms, and in test each observing time point highest stimulus index is not 0, therefore skin irritatin
Experiments have shown that aerosol of the present invention is nonirritant.
3 aerosol content bactericidal property of test example is tested
1. subjects：Embodiment 1-4 prepared inhalation aerosol compositions.
2. test material：Added with staphylococcus aureus (ATCC 6538), the pseudomonas aeruginosa of equivalent 3%BSA
(ATCC 15442) and Candida albicans (ATCC 10231), is derived from China General Microbiological Culture Collection Center.
3. test method：
1.0ml bacteria suspensions are taken to be added in 4.0ml aerosol combinations, mixing acts on to the predetermined time, 0.5ml is taken to mix
4.5ml neutralizers are added in liquid, make viable bacteria culture after neutralization 10min and count, calculate and kill logarithm.
4. test result：
7 aerosol combination bactericidal property test result of table
As shown in Table 7, which acts on staphylococcus aureus, pseudomonas aeruginosa, Candida albicans
1min, 2min and 3min kill logarithm >=5.0, reach disinfection Eligibility requirements.
4 aerosol products stability test of test example
1. subjects：Embodiment 1 and comparative example 1-3 prepared inhalation aerosols.
2. test method：
According to GB/T 14449-2008《Aerosol products test method》Aerosol content stability is tested,
It includes smell, appearance, phase to test content mainly.
3. test result：Test result is shown in Table 8.
Table 8 aerosol, 50 ± 2 DEG C of storage test results
As shown in Table 8：
(1) after embodiment 1 is stored 8 weeks at 50 ± 2 DEG C, smell, appearance and phase maintain a good state, and stability is good.
(2) aerosol that comparative example 1 (Sodium Caseinate replaces with sorbitol anhydride laurate) is prepared occurred in the 6th week
The phenomenon that water oil layer, a small amount of precipitation, fragrance is gradually thin out, illustrates that Sodium Caseinate is more suitable compared with sorbitol anhydride laurate
For aerosol system of the present invention.
(3) aerosol that comparative example 2 (no Sodium Caseinate) is prepared is stored under the same conditions, there is within the 0th week
Fine sand texture becomes grittiness on the 4th week, subsequently becomes granular sensation, starts simultaneously at generation and precipitates and gradually increase, the 6th week water oil
It is mutually layered, generates more precipitation, and fragrance is thin out, illustrate that no Sodium Caseinate, aerosol content are long placed in unstable.
(4) aerosol that comparative example 3 (modified manometer silicon dioxide is changed to silica) is prepared is in identical condition
Lower storage 8 weeks occurs as soon as a small amount of precipitation on the 2nd week, while there are thin sand types for the composition sprayed, this may be due to titanium dioxide
It is easy to reunite between silicon particle, forms precipitation, with the precipitation of carrier, fragrance is also gradually thin out.
The above-described embodiments merely illustrate the principles and effects of the present invention, and is not intended to limit the present invention.It is any ripe
The personage for knowing this technology can all carry out modifications and changes to above-described embodiment without violating the spirit and scope of the present invention.Cause
This, institute is complete without departing from the spirit and technical ideas disclosed in the present invention by those of ordinary skill in the art such as
At all equivalent modifications or change, should by the present invention claim be covered.
Claims (10)
1. a kind of cooling aerosol disinfectant composition and aerosol products, which is characterized in that including following raw material and its quality point
Number：Propellant 40-80%, pure water 10-50%, absolute ethyl alcohol 0.1-10%, excipient 0.31-1.3% and fungicide 0.001-
0.02%.
2. cooling aerosol disinfectant composition according to claim 1, which is characterized in that the propellant is selected from diformazan
At least one of ether, liquefied petroleum gas, HFC-152a, HFC-134a and HFO-1234ze.
3. cooling aerosol disinfectant composition according to claim 1, which is characterized in that the fungicide is adjacent phenyl benzene
Phenol.
4. cooling aerosol disinfectant composition according to claim 1, which is characterized in that the excipient is by ethoxy fibre
Dimension element, Sodium Caseinate and modified manometer silicon dioxide are with weight ratio (1-5):(1-5):(1-10) is formed.
5. cooling aerosol disinfectant composition according to claim 4, which is characterized in that the modified manometer silicon dioxide
Preparation method be：
Nano silicon dioxide is put into absolute ethyl alcohol, ultrasonic disperse 30min is carried out, obtains system A；System A is placed in reaction
In kettle, 200-300 DEG C of temperature is set, pressure 15-30MPa reacts 2-6h, obtains modified manometer silicon dioxide.
6. cooling aerosol disinfectant composition according to claim 1 or 2, which is characterized in that the aerosol combination
Further include emollient, the mass fraction of the emollient is 0.045-0.36%；The emollient be selected from isopropyl myristate,
It is one or more in isomery dodecane, glycerine and 1,3 butylene glycol.
7. cooling aerosol disinfectant composition according to claim 1 or 2, which is characterized in that the aerosol combination
Further include menthol, the mass fraction of the menthol is 0.02-0.22%.
8. cooling aerosol disinfectant composition according to claim 1 or 2, which is characterized in that the aerosol combination
Further include annular siloxane, the mass fraction of the annular siloxane is 0.001-0.02%.
9. cooling aerosol disinfectant composition according to claim 1 or 2, which is characterized in that the aerosol combination
Further include aromatic, the aromatic is p- anisic acids, mass fraction 0.01-0.15%.
10. a kind of cooling aerosol disinfectant product, which is characterized in that the aerosol products include as appointed in claim 1-9
Cooling aerosol disinfectant composition described in one and the inhalator jar for canned the composition, the inhalator jar are equipped with 360 °
Valve, can just, stand upside down injection；
It is described cooling aerosol disinfectant product preparation method be：
S1, oil phase and water phase are prepared respectively, oil phase, which is then mixed with water conjunction stirring homogeneous, becomes lotion；
S2, lotion obtained by step S1 is poured into inhalator jar, fills valve, sealing fills propellant, and water-bath fills nozzle, and dress is outer
Lid, vanning.
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| CN201810136926.1A CN108272654B (en) | 2018-02-09 | 2018-02-09 | Cooling sterilization aerosol composition and aerosol product |
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| CN201810136926.1A CN108272654B (en) | 2018-02-09 | 2018-02-09 | Cooling sterilization aerosol composition and aerosol product |
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| CN108272654B CN108272654B (en) | 2021-05-11 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111821838A (en) * | 2019-04-20 | 2020-10-27 | 广东阜和实业有限公司 | Aerosol type air deodorant and preparation method thereof |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102670421A (en) * | 2012-05-24 | 2012-09-19 | 中山市天图精细化工有限公司 | Aerosol composition for cooling and refreshing for personal nursing and aerosol product containing aerosol composition |
| CN102861206A (en) * | 2011-07-07 | 2013-01-09 | 万绪山 | Sterilizing and disinfecting aerosol for skin mucous membrane and preparation method thereof |
-
2018
- 2018-02-09 CN CN201810136926.1A patent/CN108272654B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102861206A (en) * | 2011-07-07 | 2013-01-09 | 万绪山 | Sterilizing and disinfecting aerosol for skin mucous membrane and preparation method thereof |
| CN102670421A (en) * | 2012-05-24 | 2012-09-19 | 中山市天图精细化工有限公司 | Aerosol composition for cooling and refreshing for personal nursing and aerosol product containing aerosol composition |
Non-Patent Citations (1)
| Title |
|---|
| 吉小利等: "纳米二氧化硅粉体的表面改性研究", 《安徽理工大学学报(自然科学版)》 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111821838A (en) * | 2019-04-20 | 2020-10-27 | 广东阜和实业有限公司 | Aerosol type air deodorant and preparation method thereof |
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