CN108271964A - 一种护胃的宣木瓜饮料及其制备方法和应用 - Google Patents
一种护胃的宣木瓜饮料及其制备方法和应用 Download PDFInfo
- Publication number
- CN108271964A CN108271964A CN201711412694.XA CN201711412694A CN108271964A CN 108271964 A CN108271964 A CN 108271964A CN 201711412694 A CN201711412694 A CN 201711412694A CN 108271964 A CN108271964 A CN 108271964A
- Authority
- CN
- China
- Prior art keywords
- parts
- xuancheng
- pawpaw
- beverage
- stomach
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 244000189799 Asimina triloba Species 0.000 title claims abstract description 33
- 235000006264 Asimina triloba Nutrition 0.000 title claims abstract description 33
- 235000009467 Carica papaya Nutrition 0.000 title claims abstract description 33
- 210000002784 stomach Anatomy 0.000 title claims abstract description 32
- 235000013361 beverage Nutrition 0.000 title claims abstract description 28
- 238000002360 preparation method Methods 0.000 title claims abstract description 9
- 240000002943 Elettaria cardamomum Species 0.000 claims abstract description 14
- 244000223082 Syzygium paniculatum Species 0.000 claims abstract description 14
- 235000016641 Syzygium paniculatum Nutrition 0.000 claims abstract description 14
- 235000005300 cardamomo Nutrition 0.000 claims abstract description 14
- 240000001008 Dimocarpus longan Species 0.000 claims abstract description 13
- 235000000235 Euphoria longan Nutrition 0.000 claims abstract description 13
- 244000185386 Thladiantha grosvenorii Species 0.000 claims abstract description 13
- 235000011171 Thladiantha grosvenorii Nutrition 0.000 claims abstract description 13
- 241000522254 Cassia Species 0.000 claims abstract description 12
- 239000002994 raw material Substances 0.000 claims abstract description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 32
- 239000000463 material Substances 0.000 claims description 23
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 21
- 235000019441 ethanol Nutrition 0.000 claims description 20
- 239000012141 concentrate Substances 0.000 claims description 11
- 239000000706 filtrate Substances 0.000 claims description 6
- 238000001914 filtration Methods 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 230000006837 decompression Effects 0.000 claims description 5
- 239000000047 product Substances 0.000 claims description 5
- 229930006000 Sucrose Natural products 0.000 claims description 4
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 4
- 239000005720 sucrose Substances 0.000 claims description 4
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 3
- 239000008101 lactose Substances 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 claims description 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 2
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 2
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims description 2
- 239000001768 carboxy methyl cellulose Substances 0.000 claims description 2
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims description 2
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims description 2
- 235000013372 meat Nutrition 0.000 claims description 2
- 229920000609 methyl cellulose Polymers 0.000 claims description 2
- 239000001923 methylcellulose Substances 0.000 claims description 2
- 235000010981 methylcellulose Nutrition 0.000 claims description 2
- 229940013618 stevioside Drugs 0.000 claims description 2
- OHHNJQXIOPOJSC-UHFFFAOYSA-N stevioside Natural products CC1(CCCC2(C)C3(C)CCC4(CC3(CCC12C)CC4=C)OC5OC(CO)C(O)C(O)C5OC6OC(CO)C(O)C(O)C6O)C(=O)OC7OC(CO)C(O)C(O)C7O OHHNJQXIOPOJSC-UHFFFAOYSA-N 0.000 claims description 2
- 235000019202 steviosides Nutrition 0.000 claims description 2
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 claims 1
- 235000019082 Osmanthus Nutrition 0.000 claims 1
- 241000333181 Osmanthus Species 0.000 claims 1
- 235000009754 Vitis X bourquina Nutrition 0.000 claims 1
- 235000012333 Vitis X labruscana Nutrition 0.000 claims 1
- 240000006365 Vitis vinifera Species 0.000 claims 1
- 235000014787 Vitis vinifera Nutrition 0.000 claims 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 claims 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 claims 1
- 230000000694 effects Effects 0.000 description 10
- 239000003814 drug Substances 0.000 description 8
- 229940079593 drug Drugs 0.000 description 7
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 6
- 241000700159 Rattus Species 0.000 description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 6
- 210000004072 lung Anatomy 0.000 description 6
- 241000196324 Embryophyta Species 0.000 description 5
- 239000008280 blood Substances 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 5
- 235000013399 edible fruits Nutrition 0.000 description 5
- 230000001737 promoting effect Effects 0.000 description 5
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 4
- 239000008103 glucose Substances 0.000 description 4
- 206010047700 Vomiting Diseases 0.000 description 3
- 238000010171 animal model Methods 0.000 description 3
- 230000003796 beauty Effects 0.000 description 3
- 230000004087 circulation Effects 0.000 description 3
- 238000005516 engineering process Methods 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 210000000952 spleen Anatomy 0.000 description 3
- MIJYXULNPSFWEK-GTOFXWBISA-N 3beta-hydroxyolean-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C MIJYXULNPSFWEK-GTOFXWBISA-N 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 2
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 description 2
- 244000144725 Amygdalus communis Species 0.000 description 2
- 235000011437 Amygdalus communis Nutrition 0.000 description 2
- 206010011224 Cough Diseases 0.000 description 2
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 description 2
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- JKLISIRFYWXLQG-UHFFFAOYSA-N Epioleonolsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4CCC3C21C JKLISIRFYWXLQG-UHFFFAOYSA-N 0.000 description 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 2
- 208000007882 Gastritis Diseases 0.000 description 2
- 206010030113 Oedema Diseases 0.000 description 2
- YBRJHZPWOMJYKQ-UHFFFAOYSA-N Oleanolic acid Natural products CC1(C)CC2C3=CCC4C5(C)CCC(O)C(C)(C)C5CCC4(C)C3(C)CCC2(C1)C(=O)O YBRJHZPWOMJYKQ-UHFFFAOYSA-N 0.000 description 2
- MIJYXULNPSFWEK-UHFFFAOYSA-N Oleanolinsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4=CCC3C21C MIJYXULNPSFWEK-UHFFFAOYSA-N 0.000 description 2
- 241000287127 Passeridae Species 0.000 description 2
- 102000057297 Pepsin A Human genes 0.000 description 2
- 108090000284 Pepsin A Proteins 0.000 description 2
- 235000014931 Prunus triloba Nutrition 0.000 description 2
- 241000481932 Prunus triloba Species 0.000 description 2
- ABBQHOQBGMUPJH-UHFFFAOYSA-M Sodium salicylate Chemical compound [Na+].OC1=CC=CC=C1C([O-])=O ABBQHOQBGMUPJH-UHFFFAOYSA-M 0.000 description 2
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 2
- 229930003268 Vitamin C Natural products 0.000 description 2
- 235000020224 almond Nutrition 0.000 description 2
- 239000000908 ammonium hydroxide Substances 0.000 description 2
- VIROVYVQCGLCII-UHFFFAOYSA-N amobarbital Chemical compound CC(C)CCC1(CC)C(=O)NC(=O)NC1=O VIROVYVQCGLCII-UHFFFAOYSA-N 0.000 description 2
- 230000004596 appetite loss Effects 0.000 description 2
- 230000017531 blood circulation Effects 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 235000015165 citric acid Nutrition 0.000 description 2
- 229960004106 citric acid Drugs 0.000 description 2
- 235000009508 confectionery Nutrition 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 210000001198 duodenum Anatomy 0.000 description 2
- 201000006549 dyspepsia Diseases 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 210000003414 extremity Anatomy 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 210000004051 gastric juice Anatomy 0.000 description 2
- 238000003304 gavage Methods 0.000 description 2
- 241000411851 herbal medicine Species 0.000 description 2
- 210000002429 large intestine Anatomy 0.000 description 2
- 208000019017 loss of appetite Diseases 0.000 description 2
- 235000021266 loss of appetite Nutrition 0.000 description 2
- 229940100243 oleanolic acid Drugs 0.000 description 2
- 229940111202 pepsin Drugs 0.000 description 2
- HZLWUYJLOIAQFC-UHFFFAOYSA-N prosapogenin PS-A Natural products C12CC(C)(C)CCC2(C(O)=O)CCC(C2(CCC3C4(C)C)C)(C)C1=CCC2C3(C)CCC4OC1OCC(O)C(O)C1O HZLWUYJLOIAQFC-UHFFFAOYSA-N 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 229960004025 sodium salicylate Drugs 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 208000024891 symptom Diseases 0.000 description 2
- 235000002906 tartaric acid Nutrition 0.000 description 2
- 239000011975 tartaric acid Substances 0.000 description 2
- 229960001367 tartaric acid Drugs 0.000 description 2
- 235000019154 vitamin C Nutrition 0.000 description 2
- 239000011718 vitamin C Substances 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- 238000010792 warming Methods 0.000 description 2
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- LVRVABPNVHYXRT-BQWXUCBYSA-N 52906-92-0 Chemical compound C([C@H](N)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(N)=O)C(O)=O)C(C)C)C1=CC=CC=C1 LVRVABPNVHYXRT-BQWXUCBYSA-N 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 206010000077 Abdominal mass Diseases 0.000 description 1
- 229930024421 Adenine Natural products 0.000 description 1
- GFFGJBXGBJISGV-UHFFFAOYSA-N Adenine Chemical compound NC1=NC=NC2=C1N=CN2 GFFGJBXGBJISGV-UHFFFAOYSA-N 0.000 description 1
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 102000016938 Catalase Human genes 0.000 description 1
- 108010053835 Catalase Proteins 0.000 description 1
- 240000006122 Chenopodium album Species 0.000 description 1
- 235000009344 Chenopodium album Nutrition 0.000 description 1
- 241000675108 Citrus tangerina Species 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 102400000921 Gastrin Human genes 0.000 description 1
- 108010052343 Gastrins Proteins 0.000 description 1
- 206010019909 Hernia Diseases 0.000 description 1
- STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 241000507649 Kerria japonica Species 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 101800002372 Motilin Proteins 0.000 description 1
- 102400001357 Motilin Human genes 0.000 description 1
- STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 description 1
- 208000002193 Pain Diseases 0.000 description 1
- 108091005804 Peptidases Proteins 0.000 description 1
- 201000005702 Pertussis Diseases 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
- 239000004365 Protease Substances 0.000 description 1
- 240000000191 Prunus tomentosa Species 0.000 description 1
- 235000018997 Prunus tomentosa Nutrition 0.000 description 1
- 241000220324 Pyrus Species 0.000 description 1
- 206010067171 Regurgitation Diseases 0.000 description 1
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 241001627955 Tetraodon lineatus Species 0.000 description 1
- 206010044565 Tremor Diseases 0.000 description 1
- 241000209140 Triticum Species 0.000 description 1
- 235000021307 Triticum Nutrition 0.000 description 1
- 102000003425 Tyrosinase Human genes 0.000 description 1
- 108060008724 Tyrosinase Proteins 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 210000000683 abdominal cavity Anatomy 0.000 description 1
- 206010000059 abdominal discomfort Diseases 0.000 description 1
- 208000019790 abdominal distention Diseases 0.000 description 1
- 230000003187 abdominal effect Effects 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 229960000643 adenine Drugs 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229960001301 amobarbital Drugs 0.000 description 1
- 230000003444 anaesthetic effect Effects 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 229960005070 ascorbic acid Drugs 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 210000004204 blood vessel Anatomy 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 150000001720 carbohydrates Chemical class 0.000 description 1
- 210000002318 cardia Anatomy 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 235000010980 cellulose Nutrition 0.000 description 1
- 235000001122 chang geng bian tao Nutrition 0.000 description 1
- AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 description 1
- 210000000038 chest Anatomy 0.000 description 1
- 229960001231 choline Drugs 0.000 description 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000012790 confirmation Methods 0.000 description 1
- 238000004320 controlled atmosphere Methods 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940000406 drug candidate Drugs 0.000 description 1
- 208000001848 dysentery Diseases 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 229940088598 enzyme Drugs 0.000 description 1
- 210000003238 esophagus Anatomy 0.000 description 1
- 239000003777 experimental drug Substances 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 229930003944 flavone Natural products 0.000 description 1
- 150000002213 flavones Chemical class 0.000 description 1
- 235000011949 flavones Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 235000021022 fresh fruits Nutrition 0.000 description 1
- 239000001530 fumaric acid Substances 0.000 description 1
- 235000011087 fumaric acid Nutrition 0.000 description 1
- 229960002598 fumaric acid Drugs 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 210000001156 gastric mucosa Anatomy 0.000 description 1
- 210000004907 gland Anatomy 0.000 description 1
- 125000002791 glucosyl group Chemical group C1([C@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- LHVVWWADJUJFEH-HKNOZQPISA-N hexadecanoic acid (9Z,12Z)-octadeca-9,12-dienoic acid octadecanoic acid (9Z,12Z,15Z)-octadeca-9,12,15-trienoic acid (Z)-octadec-9-enoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O.CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCC\C=C/C\C=C/CCCCCCCC(O)=O.CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O LHVVWWADJUJFEH-HKNOZQPISA-N 0.000 description 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 210000003127 knee Anatomy 0.000 description 1
- 239000006101 laboratory sample Substances 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 229940099690 malic acid Drugs 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 239000011259 mixed solution Substances 0.000 description 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
- 238000003305 oral gavage Methods 0.000 description 1
- 230000001590 oxidative effect Effects 0.000 description 1
- 230000001575 pathological effect Effects 0.000 description 1
- 235000021017 pears Nutrition 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 230000000291 postprandial effect Effects 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 210000001187 pylorus Anatomy 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 239000001397 quillaja saponaria molina bark Substances 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 238000011552 rat model Methods 0.000 description 1
- 230000001603 reducing effect Effects 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- 229930182490 saponin Natural products 0.000 description 1
- 150000007949 saponins Chemical class 0.000 description 1
- 235000017709 saponins Nutrition 0.000 description 1
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 description 1
- 229960002646 scopolamine Drugs 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 235000018553 tannin Nutrition 0.000 description 1
- 239000001648 tannin Substances 0.000 description 1
- 229920001864 tannin Polymers 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000035922 thirst Effects 0.000 description 1
- 201000004647 tinea pedis Diseases 0.000 description 1
- 235000013619 trace mineral Nutrition 0.000 description 1
- 239000011573 trace mineral Substances 0.000 description 1
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 210000002417 xiphoid bone Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation containing fruit or vegetable juices
- A23L2/04—Extraction of juices
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Their preparation
- A23L2/52—Adding ingredients
- A23L2/60—Sweeteners
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/732—Chaenomeles, e.g. flowering quince
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
- A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9064—Amomum, e.g. round cardamom
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Abstract
本发明提供了一种护胃的宣木瓜饮料，它由如下重量份数的原料制备得到：宣木瓜25‑35份、龙眼肉10‑20份、罗汉果15‑25份、橘皮15‑25份、白豆蔻10‑20份、砂仁10‑20份、肉桂10‑20份、郁李仁5‑15份，具有护胃的功能，并公开了制备方法和用途。
Description
技术领域
本发明涉及保健品技术领域，具体涉及一种护胃的宣木瓜饮料及其制备方法和应用。
背景技术
胃不舒服主要表现为上腹部饱胀、不适或疼痛，餐后明显，同时伴有其他消化不良症状如嗳气、反酸、恶心、呕吐、食欲不振等。人们迫切需要一种行之有效、己被大多数人证实能起良好效果的护胃保健品。
发明内容
发明目的：为了解决上述问题，本发明的目的在于提供一种护胃的宣木瓜饮料及其制备方法和应用。
技术方案：本发明的目的是通过如下的方案实现的：
一种护胃的宣木瓜饮料，它由如下重量份数的原料制备得到：宣木瓜25-35份、龙眼肉10-20份、罗汉果15-25份、橘皮15-25份、白豆蔻10-20份、砂仁10-20份、肉桂10-20份、郁李仁5-15份。
所述护胃的宣木瓜饮料，它由如下重量份数的原料制备得到：宣木瓜30份、龙眼肉15份、罗汉果20份、橘皮20份、白豆蔻15份、砂仁15份、肉桂15份、郁李仁10份。
所述护胃的宣木瓜饮料，所述原料经提取后添加辅料制成饮料。
所述护胃的宣木瓜饮料，所述辅料为乳糖、蔗糖、葡萄糖、甘露糖、甲基纤维素、羟丙基纤维素、羧甲基纤维素和甜菊苷的一种或几种。
所述护胃的宣木瓜饮料，制备方法包括如下步骤：取宣木瓜、龙眼肉、罗汉果、橘皮、白豆蔻、砂仁、肉桂、郁李仁药材合并，加水煎煮两次，合并煎液，减压浓缩至65℃时相对密度为1.15-1.20的浸膏，加乙醇使含醇量的体积百分比达75-85％，搅拌，静置，过滤，滤液减压浓缩至65℃时相对密度为1.25-1.30，并回收乙醇，得浓缩液，将浓缩液加水及辅料配制成饮料。
所述护胃的宣木瓜饮料，制备方法步骤中，煎煮条件为：第一次加水为药材重量的8-12倍量，煎煮1-2h，第二次加水为药材重量的6-10倍量，煎煮1-2h。
所述护胃的宣木瓜饮料在制备护胃保健品中的应用。
宣木瓜含有十九种氨基酸、十八种矿物微量元素，以及大量维生素C，同时还含有皂甙、黄酮、苹果酸、齐墩果酸、枸橼酸、柠檬酸、酒石酸、抗坏血酸、反丁烯二酸、鞣质等，含有过氧化氢酶、酚氧化酶、氧化酶，特别富含超氧化物岐化酶(SOD)和齐墩果酸。其SOD的含量是世界上所有水果中无与伦比的，一克宣木瓜鲜果SOD的含量高达3227国际单位。SOD是现代美容养颜产品的核心物质，可以有效消除体内过剩自由基，增进肌体细胞更新。齐墩果酸具有广谱抗菌作用，具有护肝降酶、促免疫、抗炎、降血脂血糖等作用。龙眼肉每100克龙眼中，水分占83％，含蛋白质1.3克、脂肪0.1克、碳水化合物15克和纤维0.4克。龙眼含有极其丰富的维生素C和钾，此外还含有大量的镁和铜，有补气益血之功效，对于治疗虚劳羸弱、失眠、健忘效果显著。果肉(干)含水分0。85％,可溶性物质79.77％,不溶性物质19。39％,灰分3.36％.可溶性物质中，有葡萄糖24。91％、蔗糖0.22％、酸类(酒石酸)1。26％、含氮物(其中含腺嘌呤和胆碱)6.309％等.尚含蛋白质5。6％、脂肪0.5％。罗汉果味甘性凉，归肺、大肠经，有润肺止咳、生津止渴的功效、适用于肺热或肺燥咳嗽、百日咳及暑热伤津口渴等，此外还有润肠通便的功效。橘皮有理气调中，燥湿化痰功效，可用于治疗脾胃气滞，脘腹胀满，呕吐，或湿浊中阻所致胸闷、纳呆、便溏，但阴津亏损，内有实热者慎用。白豆蔻为姜科植物。主产于越南、泰国等地，广东、广西、云南等地亦有栽培。原植物生于气候温暖潮湿，富含腐殖质的林下，味辛、性温，归肺、脾、胃经，功效化湿，行气，温中，止呕，临床用名白豆蔻。砂仁果实供药用，以广东阳春的品质最佳，主治脾胃气滞，宿食不消，腹痛痞胀，噎膈呕吐，寒泻冷痢。砂仁观赏价值较高，初夏可赏花，盛夏可观果。肉桂补元阳，暖脾胃，除积冷，通血脉。治命门火衰，肢冷脉微，亡阳虚脱，腹痛泄泻，寒疝奔豚，腰膝冷痛，经闭症瘕，阴疽，流注，及虚阳浮越，上热下寒。郁李仁为蔷薇科植物郁李、欧李、榆叶梅、长梗扁桃等的种仁。又名郁子(《医心方》)，郁里仁(《珍珠囊》)，李仁肉(《药材学》)，小李仁(《全国中草药汇编》)。原植物郁李又名：常棣(《尔雅》)，白棣(《说文》)，爵李(《本经》)，雀李、车下李(《吴普本草》)，山李、爵梅(《广雅》)，雀梅(《本草经集注》)，棣梨、样藜(《滇南本草》)，秧李、穿心梅(《植物名实图考》)；榆叶梅又名：山樱桃、赤棣(《尔雅义疏》)；长梗扁桃又名：长柄扁桃(《中国果树分类学》)。郁李仁采摘于夏秋两季，晒干而得。其性平，味苦、甘，有润肺滑肠，下气利水的功效，能治疗大肠气滞，燥涩不通，小便不利，大腹水肿，四肢浮肿，脚气等症状。
有益效果：从中医理论看，本方中宣木瓜、龙眼肉、罗汉果、橘皮补气益血为君药，白豆蔻、砂仁、肉桂暖脾胃，除积冷，通血脉为臣药，郁李仁润肺滑肠，下气利水为佐使药，诸药相合，用于护胃。
具体实施方式
以下通过实施例形式，对本发明的上述内容再作进一步的详细说明，但不应将此理解为本发明上述主题的范围仅限于以下的实例，凡基于本发明上述内容所实现的技术均属于本发明的范围。
实施例1：取宣木瓜25份、龙眼肉20份、罗汉果15份、橘皮25份、白豆蔻10份、砂仁20份、肉桂10份、郁李仁15份药材合并，加水煎煮两次，第一次加水为药材重量的8倍量，煎煮1h，第二次加水为药材重量的6倍量，煎煮1h，合并煎液，加乙醇使含醇量的体积百分比达75％，搅拌，静置，过滤，滤液减压浓缩至65℃时相对密度为1.30，并回收乙醇，得浓缩液，将浓缩液加蔗糖配制成饮料。
实施例2：取宣木瓜35份、龙眼肉10份、罗汉果25份、橘皮15份、白豆蔻20份、砂仁10份、肉桂20份、郁李仁5份药材合并，加水煎煮两次，第一次加水为药材重量的10倍量，煎煮1.5h，第二次加水为药材重量的8倍量，煎煮1.5h，合并煎液，加乙醇使含醇量的体积百分比达85％，搅拌，静置，过滤，滤液减压浓缩至65℃时相对密度为1.25，并回收乙醇，得浓缩液，将浓缩液加乳糖配制成饮料。
实施例3：取宣木瓜30份、龙眼肉15份、罗汉果20份、橘皮20份、白豆蔻15份、砂仁15份、肉桂15份、郁李仁10份药材合并，加水煎煮两次，第一次加水为药材重量的12倍量，煎煮2h，第二次加水为药材重量的10倍量，煎煮2h，合并煎液，加乙醇使含醇量的体积百分比达80％，搅拌，静置，过滤，滤液减压浓缩至65℃时相对密度为1.28，并回收乙醇，得浓缩液，将浓缩液加葡萄糖配制成饮料。
实施例4：取宣木瓜30份、龙眼肉15份、罗汉果20份、橘皮20份、白豆蔻15份、砂仁15份、肉桂15份、郁李仁10份药材合并，加水煎煮两次，第一次加水为药材重量的10倍量，煎煮1.5h，第二次加水为药材重量的8倍量，煎煮1.5h，合并煎液，加乙醇使含醇量的体积百分比达80％，搅拌，静置，过滤，滤液减压浓缩至65℃时相对密度为1.28，并回收乙醇，得浓缩液，将浓缩液加甘露糖配制成饮料。
实施例5：本发明对实验动物的影响药效学研究
实验药物：按上述实施例3方法制备实验样品。
给药剂量：每日每只200g大鼠灌胃的饮料含生药量分别为0.8g，1.6g，3.2g，则按大鼠体重计，低剂量、中剂量和高剂量分别为4g生药量/kg、8g生药量/kg和16g生药量/kg。
实验动物：SD清洁级大鼠60只，雄性，体重180～210g，上海斯莱克实验动物中心提供。
实验试剂：维酶素片，河北环海药业有限公司，批号20150621；水杨酸钠，江苏永华精细化学品有限公司，批号120719；95％医用酒精，南京宁试化学试剂有限公司，批号20131112；氨水，成都市科龙化工试剂厂，批号20120612；胃动素、胃泌素放免试剂盒，北京福瑞生物工程公司。
实验过程：随机将60只大鼠分为6组，分别为：空白组、模型组、维酶素组、本发明小剂量组、本发明中剂量组、本发明大剂量组，每组l0只，造模除空白组正常饲养外，其它5组采用2％水杨酸钠和30％酒精混合溶液，每日固定时间灌胃，灌胃前后禁食禁水1h，10mL/kg；大鼠自由饮用0.05％氨水；配合饥饱失常法，每进食2d，禁食1d。造模结束前随机抽取两只作胃黏膜病理组织学检查，确认出现胃黏膜腺体萎缩，肠化和不典型增生等，停止造模药物，进入治疗阶段。造模共计17周。治疗共计4周。结束后，大鼠禁食24h，1.5％戊巴比妥腹腔注射麻醉，于剑突下沿腹白线剪开一个约2.5cm的切口，小心提起胃，在幽门与十二指肠结合部用缝合线结扎，避开血管。缝合创口后送回笼中。3h后，再结扎贲门，分别剪断食道下端及十二指肠近端，摘出全胃，洗去表面血污，用滤纸吸干，置培养皿内沿胃大弯剪开胃腔，收集胃液到离心管中，以3000rpm离心20min，吸取上清液，进行胃液分析，麦特毛细管法测胃蛋白酶，结果如下：
本发明对胃蛋白酶影响研究(X±SD)
注：与模型组比较，*P<0.05；**P<0.01
实验结论：本发明可提高胃炎模型大鼠胃液中胃蛋白酶活性，显示出对胃炎具有一定的治疗作用，能护胃。
Claims (7)
1.一种护胃的宣木瓜饮料，其特征在于，它由如下重量份数的原料制备得到：宣木瓜25-35份、龙眼肉10-20份、罗汉果15-25份、橘皮15-25份、白豆蔻10-20份、砂仁10-20份、肉桂10-20份、郁李仁5-15份。
2.根据权利要求1所述护胃的宣木瓜饮料，其特征在于，它由如下重量份数的原料制备得到：宣木瓜30份、龙眼肉15份、罗汉果20份、橘皮20份、白豆蔻15份、砂仁15份、肉桂15份、郁李仁10份。
3.根据权利要求1或2所述护胃的宣木瓜饮料，其特征在于，所述原料经提取后添加辅料制成饮料。
4.根据权利要求3所述护胃的宣木瓜饮料，其特征在于，所述辅料为乳糖、蔗糖、葡萄糖、甘露糖、甲基纤维素、羟丙基纤维素、羧甲基纤维素和甜菊苷的一种或几种。
5.根据权利要求1所述护胃的宣木瓜饮料，其特征在于，制备方法包括如下步骤：取宣木瓜、龙眼肉、罗汉果、橘皮、白豆蔻、砂仁、肉桂、郁李仁药材合并，加水煎煮两次，合并煎液，减压浓缩至65℃时相对密度为1.15-1.20的浸膏，加乙醇使含醇量的体积百分比达75-85％，搅拌，静置，过滤，滤液减压浓缩至65℃时相对密度为1.25-1.30，并回收乙醇，得浓缩液，将浓缩液加水及辅料配制成饮料。
6.根据权利要求5所述护胃的宣木瓜饮料，其特征在于，制备方法步骤中，煎煮条件为：第一次加水为药材重量的8-12倍量，煎煮1-2h，第二次加水为药材重量的6-10倍量，煎煮1-2h。
7.权利要求1所述护胃的宣木瓜饮料在制备护胃保健品中的应用。
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711412694.XA CN108271964A (zh) | 2017-12-24 | 2017-12-24 | 一种护胃的宣木瓜饮料及其制备方法和应用 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201711412694.XA CN108271964A (zh) | 2017-12-24 | 2017-12-24 | 一种护胃的宣木瓜饮料及其制备方法和应用 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN108271964A true CN108271964A (zh) | 2018-07-13 |
Family
ID=62802048
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201711412694.XA Withdrawn CN108271964A (zh) | 2017-12-24 | 2017-12-24 | 一种护胃的宣木瓜饮料及其制备方法和应用 |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN108271964A (zh) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110583945A (zh) * | 2019-10-10 | 2019-12-20 | 宣城华科宣木瓜生物科技有限公司 | 一种护胃的宣木瓜固体饮料及其制备方法 |
| CN110623183A (zh) * | 2019-10-11 | 2019-12-31 | 宣城华科宣木瓜生物科技有限公司 | 一种调节胃动力的宣木瓜饮料及其制备方法 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1171898A (zh) * | 1997-04-13 | 1998-02-04 | 陈冠卿 | 一种能防治胃病的康胃食品及其制备方法 |
| CN1606990A (zh) * | 2003-10-13 | 2005-04-20 | 郑洪彬 | 一种健胃肠的药 |
| CN107048388A (zh) * | 2017-04-27 | 2017-08-18 | 北京市永康年健康科技有限责任公司 | 一种养胃食品调理剂 |
| CN107149069A (zh) * | 2017-05-12 | 2017-09-12 | 佛山美伲生物科技有限公司 | 一种功能饮料、固体饮料及制备方法 |
-
2017
- 2017-12-24 CN CN201711412694.XA patent/CN108271964A/zh not_active Withdrawn
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1171898A (zh) * | 1997-04-13 | 1998-02-04 | 陈冠卿 | 一种能防治胃病的康胃食品及其制备方法 |
| CN1606990A (zh) * | 2003-10-13 | 2005-04-20 | 郑洪彬 | 一种健胃肠的药 |
| CN107048388A (zh) * | 2017-04-27 | 2017-08-18 | 北京市永康年健康科技有限责任公司 | 一种养胃食品调理剂 |
| CN107149069A (zh) * | 2017-05-12 | 2017-09-12 | 佛山美伲生物科技有限公司 | 一种功能饮料、固体饮料及制备方法 |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110583945A (zh) * | 2019-10-10 | 2019-12-20 | 宣城华科宣木瓜生物科技有限公司 | 一种护胃的宣木瓜固体饮料及其制备方法 |
| CN110623183A (zh) * | 2019-10-11 | 2019-12-31 | 宣城华科宣木瓜生物科技有限公司 | 一种调节胃动力的宣木瓜饮料及其制备方法 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103992924B (zh) | 增强机体免疫力的保健露酒及其制作方法 | |
| CN103719498B (zh) | 一种提高免疫力的黄精保健茶及其制备方法 | |
| CN102068707A (zh) | 一种b超使用的中药助影剂及其制备方法 | |
| CN107518383A (zh) | 一种组合物及其制备方法 | |
| CN103749822B (zh) | 一种女贞子降压降脂保健茶及其制备方法 | |
| CN111956753B (zh) | 一种药食同源的中药组合物及其制备方法和应用 | |
| CN106244371A (zh) | 一种降血糖黄精葡萄保健酒及其生产工艺 | |
| CN101253903A (zh) | 一种具有减肥功能的保健食品及其制备方法 | |
| CN106937741A (zh) | 一种脱脂亚麻籽粉防癌抗癌健康减肥法及其制备方法 | |
| CN103301413A (zh) | 一种治疗高血脂合并高血糖症的中药组合物 | |
| CN101574151A (zh) | 一种具有增强免疫力功能的营养食品及其制备方法 | |
| CN103689559A (zh) | 一种有助于改善胃肠功能的养生保健食品配方及其制备方法 | |
| CN107048386A (zh) | 一种性功能调节保健食品 | |
| CN108271964A (zh) | 一种护胃的宣木瓜饮料及其制备方法和应用 | |
| CN103005264B (zh) | 一种含有壳寡糖的保健食品及其制备方法 | |
| CN107950850A (zh) | 一种益胃生津、滋阴清热的石斛固体饮料的制备方法及应用 | |
| CN107050349A (zh) | 一种排毒活血的膏滋及其制备方法和应用 | |
| CN101283761A (zh) | 雪莲果提取物及提取方法和应用 | |
| CN105831318A (zh) | 一种多肽降糖茶及其制作方法 | |
| CN104783174A (zh) | 一种纯天然营养免疫保健固体饮料的配制方法 | |
| CN107233491A (zh) | 一种提高精力抗疲劳的玛咖组合物 | |
| CN106362067A (zh) | 一种刺梨健胃消食药物组合物及其制备方法 | |
| CN104491338B (zh) | 一种润肠通便的药食两用组合物及其制备方法 | |
| CN108524850A (zh) | 一种用于增强免疫、防治心脑血管疾病的酒制剂 | |
| CN108310212A (zh) | 一种用于延缓衰老的药物及其制备方法和应用 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20181210 Address after: 242000 Pioneering Road 23-3-2, Xuancheng Economic and Technological Development Zone, Xuancheng City, Anhui Province Applicant after: XUANCHENG HUAKE XUANMUGUA BIOTECHNOLOGY CO., LTD. Address before: 242000 Dangui Apartment, Renmin Road, Ningguo City, Xuancheng City, Anhui Province, 2 West 112 Storage, West 112, West 212 Applicant before: Ningguo balanced Health Management Company Limited |
|
| TA01 | Transfer of patent application right | ||
| WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180713 |
|
| WW01 | Invention patent application withdrawn after publication |