CN108261389A - A kind of full extracting solution composition of stem cell for being used for sensitive skin and its preparation method and application - Google Patents
A kind of full extracting solution composition of stem cell for being used for sensitive skin and its preparation method and application Download PDFInfo
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- CN108261389A CN108261389A CN201810145689.5A CN201810145689A CN108261389A CN 108261389 A CN108261389 A CN 108261389A CN 201810145689 A CN201810145689 A CN 201810145689A CN 108261389 A CN108261389 A CN 108261389A
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
- A61K8/4946—Imidazoles or their condensed derivatives, e.g. benzimidazoles
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0625—Epidermal cells, skin cells; Cells of the oral mucosa
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- C12N2500/00—Specific components of cell culture medium
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- C12N2500/32—Amino acids
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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Abstract
The present invention relates to a kind of full extracting solution compositions of stem cell for sensitive skin, wherein the factor is oozed comprising the full extracting solution of application on human skin stem cell and trace element rush, it wherein also may include one or more of other compositions such as moisturizer, pH adjusting agent, viscosity modifier, antioxidant, emulsifier and ingredient of releiving, but not spirituosity, essence or preservative.The composition is non-stimulated to skin, and can be fully absorbed for skin, and the sensitiveness of skin is more effectively improved due to greatly increasing for active constituent.
Description
Technical field
The invention belongs to beauty and make-up fields, relate generally to for the composition of sensitive skin, particularly for sensitive flesh
The composition containing non-stem cell constituents of skin.
Background technology
Sensitive skin is a kind of problem skin, may all have sensitive skin in any skin quality.It is generally acknowledged that sensitive skin
Pathological change be to make the immunity degradation of skin since Skin Cell is damaged, cuticula is thinning to lead to skin moisturizing degree not
Enough, the barrier function for eventually leading to skin is excessively weak, can not resist environmental stimuli；Then the nerve fibre of skin is due to frequent
It is excessively excited by environmental stimuli, so as to be easy to generate the generation of the uncomfortable phenomenon such as general red, fever, itch, shouting pain, erythema.
Sensitive skin generally seems that skin is relatively thin, easy allergy, and red blood silk on the face is apparent；Skin is easily general red, and one
As temperature change, supercooling or overheat, skin all easily it is general it is red, fever；Easily by bad border factor, seasonal variations and facial product
Stimulation is to cause to become sensitive skin, and may be quick with the skin of whole body due to the use of improper cosmetics in many cases
Sense.
However there is no the methods of the completely satisfactory sensitive skin for the treatment of or prevention at present.Especially daily skin shield
In reason, alcohol, essence, preservative for being carried in cosmetics, nursing product etc. increase the stimulation to sensitive skin instead, daily
The long-time service of cosmetics, nursing product, the accumulative injury to skin are even more to make the matter worse.
Chinese patent CN107569441A discloses a kind of antiallergic lightening compositions and its application, and it includes Chinese rose stem cells
With several plant extract, show it with antiallergic effect；But all vegetable-derived components of the composition, it is not easy as human body skin
Skin fully absorbs, moreover its primary efficacy is whitening, does not cause the side effect of skin allergy only at most, can not improve
It is showed through existing skin sensitivity.
Chinese patent CN105055285A discloses a kind of skin-nourishing liquid and preparation method thereof, wherein containing human nerve stem
Cell adjusts culture solution, can improve sensitive skin；But the source of human stem cell is not consistent with application, that is, skin, and only
The supernatant that stem cell has been used to cultivate, has abandoned the whole ingredients contained in stem cell completely.
Invention content
It is stingless to skin the purpose of the present invention is to provide a kind of full extracting solution composition of stem cell for sensitive skin
Swash, and can be fully absorbed for skin, be effectively improved the sensitiveness of skin.
The purpose of the present invention is what is realized by following measures：
The present invention provides a kind of full extracting solution composition of stem cell for sensitive skin, wherein complete comprising application on human skin stem cell
Extracting solution and trace element rush ooze the factor.
Preferably, the present invention is used for the full extracting solution composition of stem cell of sensitive skin, wherein also comprising moisturizer, pH tune
Save one or more of other compositions such as agent, viscosity modifier, antioxidant, emulsifier and ingredient of releiving, but not spirituosity,
Essence or preservative.Other compositions preferred vitamin E, allantoin and hyaluronic acid.
Further, the stem cell full extracting solution composition of the present invention for sensitive skin, wherein including institute
State extracting solution 800-1500 parts full application on human skin stem cell, 0.2-5 parts of vitamin E, 0.1-3 parts of allantoin and hyaluronic acid 0.1-4
Part, trace element promote to ooze 20-1000 parts of the factor, in terms of mass fraction.
Most preferably, the stem cell full extracting solution composition of the present invention for sensitive skin, wherein comprising described
2 parts of 1000 parts of the full extracting solution of application on human skin stem cell, 3 parts of vitamin E, 2 parts of allantoin and hyaluronic acid, trace element promote ooze because
500 parts of son, in terms of mass fraction.
The full extracting solution of application on human skin stem cell of the present invention refers to cultivate application on human skin stem cell 3 days or more, will contain dry thin
The supernatant that whole culture liquid mixtures of born of the same parents obtain after crushing.
Culture medium is used by the culture of application on human skin stem cell of the present invention：Basal medium is DMEM/F12,25-
30 μ g/L VEGF, 30-40 μ g/L EGF, the NGF of 5-10 μ g/L, the human albumin of 5~50mg/L, 20-30 μ g/L vitamins
E, ironic citrate 1-3mmol/L, glutamine 1-2mmol/L, gentamicin 10-100g/L, putrescine 0.8-2.0mg/L.
The present invention also provides the preparation method of the full extracting solution composition of stem cell for sensitive skin, including step
Suddenly：Application on human skin stem cell is cultivated 3 days or more, collects whole culture liquid mixtures containing stem cell, with biomixer by its
In stem cell crush, centrifuge, take supernatant, it is primary to be washed with deionized bottom precipitation, centrifuges again, takes supernatant, closes
And two supernatants, 250nm apertures membrane filtration；Then by the supernatant with trace element rush ooze the factor and/or other compositions by
Proportioning is mixed.
The present invention also provides a kind of skin care item, are extracted entirely containing the stem cell of the present invention for sensitive skin
Liquid composition and conventional cosmetic grade auxiliary agent, wherein not spirituosity, essence or preservative.
The invention further relates to the full extracting solution compositions of stem cell for sensitive skin to prepare sensitive skin use
Application in skin care item or cosmetics.
Skin care item or cosmetics of the present invention are used as conservative or rinse-off products.For example, conservative product
Can retain a period of time (such as 5-30min or 1-24h by partly application to skin and on the skin）；Washing-off type produces
Product can be application to skin then in such as less than 5min for a period of time from skin removed or the product washed away.Rinse-off products
Can be skin cleaner, shampoo, hair conditioner or soap.The example of conservative product can be skin moisturizer, sun-screening agent, face
Film, late frost or day cream.
The present invention except the full extracting solution of application on human skin stem cell be according to the method for the invention obtain in addition to, it is described other into
Such as vitamin E, allantoin, hyaluronic acid and trace element is divided to promote to ooze the factor using commercially available cosmetics-stage product, wherein
The example that micro- rush oozes the factor is derived from the ATOLIGOMER of French CODIF.
Advantageous effect
1. main active of the present invention all handles gained extracting solution after using the skin progenitor cell culture of people source, wherein being rich in
The ingredients such as the growth factor of stem cell secretion and other small-molecule active substances, particularly contain contain inside stem cell it is each
Kind growth factor isoreactivity ingredient.It is generally believed that cell is secreted into only some active material in culture solution, big portion
Active material is divided still to be present in cell interior to include in cytoplasm and nucleus.Therefore, the present invention uses full extracting solution can be with
The active ingredient of higher concentration is obtained, and reduces production cost.
Equally all it is to act on application on human skin 2. the source of stem cell of the present invention and the application of the present invention fit like a glove
Cell, structure composition is all identical with function, and active constituent naturally also can more abundant, efficiently promote sensitive flesh
The reparation for the Skin Cell that skin is damaged, what ingredient produced by also avoiding separate sources ingredient and different type cell was brought
Repellency influences.
3. the present invention also added trace element promote ooze the factor, wherein rich in minerals (magnesium, chlorine, sodium, calcium, iron, zinc,
Manganese, copper, iodine, potassium) etc. trace elements, in addition to can supplement skin histology needs trace element other than, various battalion can also be promoted
A point subcutaneously tissue infiltration effect is formed, itself has no toxic side effect.The ingredient can help the active constituent in skin care item more to fill
Point ground the tissue that penetrates to the skin in, avoid be usually applied to skin surface skin care ingredient can not be fully absorbed by skin thus
Not the problem of not having good action.
4. the present invention does not add preservative, alcohol and essence, this several constituents is often contained in cosmetics, skin care item
Ingredient, but have been generally acknowledged that they be to cause skin to one of most important factor of cosmetics, skin care item allergy.Use the present invention
Product avoid further injury to sensitive skin.
Specific embodiment
The preparation of the 1 full extracting solution of application on human skin stem cell of embodiment：
Culture medium is configured：Basal medium is DMEM/F12, NGF, 20mg/L of 25 μ g/L VEGF, 35 μ g/L EGF, 8 μ g/L
Human albumin, 25 μ g/L vitamin Es, ironic citrate 2mmol/L, glutamine 2mmol/L, gentamicin 50g/L, corruption
Amine 1.6mg/L.
Application on human skin stem cell in the culture medium is cultivated 3 days, collects whole culture liquid mixtures containing stem cell, with thin
Born of the same parents' crusher crushes stem cell therein, and intracellular small-molecule substance is made to release completely；Centrifugation, takes supernatant；With
Deionized water washing bottom precipitation is primary, centrifuges again, takes supernatant；Merge two supernatants, 250nm apertures membrane filtration, i.e.,
.
The preparation of the full extracting solution composition of 2 stem cell of embodiment
Trace element rush is oozed into 500 parts of the factor, 3 parts of vitamin E, 2 parts of allantoin, 2 parts of hyaluronic acid and adds in 1 gained of embodiment
The full extracting solution of application on human skin stem cell（1000 parts）In be sufficiently mixed uniformly, be placed in 4 DEG C of household freezers and preserve.
Unless otherwise instructed, number of the present invention is in terms of mass fraction.
The preparation of the full extracting solution composition of 3 stem cell of embodiment（Mix proportion scheme 2）
Trace element rush is oozed into 100 parts of the factor, 1 part of vitamin E, 1 part of allantoin, 1 part of hyaluronic acid and adds in 1 gained of embodiment
The full extracting solution of application on human skin stem cell（800 parts）In be sufficiently mixed uniformly, be placed in 4 DEG C of household freezers and preserve.
The preparation of the full extracting solution composition of 4 stem cell of embodiment（Mix proportion scheme 3）
Trace element rush is oozed into 1000 parts of the factor, 5 parts of vitamin E, 3 parts of allantoin, 4 parts of hyaluronic acid and adds in 1 gained of embodiment
The full extracting solution of application on human skin stem cell（1200 parts）In be sufficiently mixed uniformly, be placed in 4 DEG C of household freezers and preserve.
The product of the present invention is tested through conventional skin cell proliferation, can show its facilitation to skin cell proliferation effectively simultaneously
Enhance to a certain extent.Lactic acid irritant test to sensitive skin crowd is the results show that the sensitiveness of former sensitive is equal
Being improved, self-induction shouting pain mitigates, through doctor's observation visible dermis drying mitigates, the scales of skin that peel off is reduced, less erythema occurs again, and
Conventional skin care condition ratio with claiming antiallergic, usage time is shorter can to obtain the sensibility improvement become apparent.This
The product of invention is detected through other inspections, shows that it also complies with the requirement of national cosmetic related quality criterion.
Those skilled in the art are aware that, more than specific embodiment and embodiment be the exemplary description present invention some compared with
Good scheme does not play the present invention limitation in any form, in the protection domain limited without departing from claim
Under the premise of, the present invention can also carry out other and change and adjust.
Claims (10)
1. a kind of full extracting solution composition of stem cell for sensitive skin, wherein including the full extracting solution of application on human skin stem cell and micro-
Secondary element rush oozes the factor.
2. the stem cell full extracting solution composition as described in claim 1 for sensitive skin, wherein also comprising moisturizer, pH
One or more of other compositions such as conditioning agent, viscosity modifier, antioxidant, emulsifier and ingredient of releiving, but without wine
Essence, essence or preservative.
3. the stem cell full extracting solution composition as claimed in claim 2 for sensitive skin, wherein the other compositions
For vitamin E, allantoin and hyaluronic acid.
4. the stem cell full extracting solution composition as claimed in claim 3 for sensitive skin, wherein being done comprising the skin
Cell is extracting solution 800-1500 parts complete, 0.2-5 parts of vitamin E, 0.1-3 parts of allantoin and 0.1-4 parts of hyaluronic acid, micro member
Element promotees to ooze 20-1000 parts of the factor, in terms of mass fraction.
5. the stem cell full extracting solution composition as claimed in claim 4 for sensitive skin, wherein being done comprising the skin
2 parts of 1000 parts of the full extracting solution of cell, 3 parts of vitamin E, 2 parts of allantoin and hyaluronic acid, trace element promote to ooze 500 parts of the factor,
In terms of mass fraction.
6. as claim 1-5 any one of them is used for the full extracting solution composition of stem cell of sensitive skin, wherein the skin
The full extracting solution of skin stem cell is that application on human skin stem cell is cultivated 3 days or more, and whole culture liquid mixtures containing stem cell are crushed
The supernatant obtained afterwards.
7. the stem cell full extracting solution composition as claimed in claim 6 for sensitive skin, wherein the application on human skin is done carefully
Culture medium is used by the culture of born of the same parents：Basal medium is DMEM/F12,25-30 μ g/L VEGF, 30-40 μ g/L EGF, 5-
The NGF of 10 μ g/L, the human albumin of 5~50mg/L, 20-30 μ g/L vitamin Es, ironic citrate 1-3mmol/L, glutamine
1-2mmol/L, gentamicin 10-100g/L, putrescine 0.8-2.0mg/L.
8. claim 1-7 any one of them is used for the preparation method of the full extracting solution composition of stem cell of sensitive skin,
Include step：Application on human skin stem cell is cultivated 3 days or more, collects whole culture liquid mixtures containing stem cell, is broken with cell
Broken machine crushes stem cell therein, and centrifugation takes supernatant, and it is primary to be washed with deionized bottom precipitation, centrifuges, takes again
Clear liquid merges two supernatants, 250nm apertures membrane filtration；Then by the supernatant with trace element rush ooze the factor and/or other
Ingredient is mixed by proportioning.
9. a kind of skin care item are used for the full extracting solution group of stem cell of sensitive skin containing claim 1-7 any one of them
Object and conventional cosmetic grade auxiliary agent are closed, wherein not spirituosity, essence or preservative.
10. the full extracting solution composition of stem cell that claim 1-7 any one of them is used for sensitive skin is preparing sensitive flesh
Application in skin skin care item or cosmetics.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201810145689.5A CN108261389A (en) | 2018-02-12 | 2018-02-12 | A kind of full extracting solution composition of stem cell for being used for sensitive skin and its preparation method and application |
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| CN201810145689.5A CN108261389A (en) | 2018-02-12 | 2018-02-12 | A kind of full extracting solution composition of stem cell for being used for sensitive skin and its preparation method and application |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111265467A (en) * | 2018-12-04 | 2020-06-12 | 上海梅格医疗器械有限公司 | An anti-allergy repairing agent prepared by mixing stem cell extract and compound plant extract, and its preparation method |
| US11450732B2 (en) | 2019-03-08 | 2022-09-20 | Suzhou Tf-Amd Semiconductor Co. Ltd. | Structure for capacitor protection, package structure, and method of forming package structure |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1618981A (en) * | 2003-11-20 | 2005-05-25 | 中国人民解放军军事医学科学院野战输血研究所 | Dry cell secretion factor and its preparation method and application |
| CN104983646A (en) * | 2015-07-31 | 2015-10-21 | 桂林市宏旭生物科技有限公司 | Night maintenance mask solution and preparation method thereof |
| CN105055285A (en) * | 2015-08-26 | 2015-11-18 | 浙江奥瑞健生物技术有限公司 | Skin nutrition liquid and preparation method thereof |
-
2018
- 2018-02-12 CN CN201810145689.5A patent/CN108261389A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1618981A (en) * | 2003-11-20 | 2005-05-25 | 中国人民解放军军事医学科学院野战输血研究所 | Dry cell secretion factor and its preparation method and application |
| CN104983646A (en) * | 2015-07-31 | 2015-10-21 | 桂林市宏旭生物科技有限公司 | Night maintenance mask solution and preparation method thereof |
| CN105055285A (en) * | 2015-08-26 | 2015-11-18 | 浙江奥瑞健生物技术有限公司 | Skin nutrition liquid and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111265467A (en) * | 2018-12-04 | 2020-06-12 | 上海梅格医疗器械有限公司 | An anti-allergy repairing agent prepared by mixing stem cell extract and compound plant extract, and its preparation method |
| US11450732B2 (en) | 2019-03-08 | 2022-09-20 | Suzhou Tf-Amd Semiconductor Co. Ltd. | Structure for capacitor protection, package structure, and method of forming package structure |
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