CN108260593A - A kind of bactericidal composition - Google Patents
A kind of bactericidal composition Download PDFInfo
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- CN108260593A CN108260593A CN201611258113.7A CN201611258113A CN108260593A CN 108260593 A CN108260593 A CN 108260593A CN 201611258113 A CN201611258113 A CN 201611258113A CN 108260593 A CN108260593 A CN 108260593A
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- bactericidal composition
- rot
- propiconazole
- pyrimethanil
- plant
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
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- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention relates to a kind of bactericidal compositions, further relate to a kind of method for preventing plant pathogen；The method for more particularly to preventing Cereal, fruit, the fungi of vegetable storage phase and bacteriosis.A kind of bactericidal composition of the present invention, active constituent are made of propiconazole and pyrimethanil, and the weight ratio of propiconazole and pyrimethanil is 10:1‑1:50.The invention further relates to the bactericidal compositions for preventing Cereal, veterinary antibiotics, the purposes of fungi and bacterium on ornamental plant and grapevine.The invention particularly relates to the bactericidal compositions for protecting fruit or vegetables stock in storage period from fungi or the purposes of bacterial invasion.
Description
Technical field
The present invention relates to a kind of bactericidal compositions, further relate to a kind of method for preventing plant pathogen；More particularly to
The method for preventing Cereal, fruit, the fungi of vegetable storage phase and bacteriosis.
Background technology
About pesticide activity, particularly to crop protection, one of key problem of research carried out in the technical field is
Improve the performance in terms of performance, especially bioactivity and the performance in terms of keeping this activity within a certain period of time.
Pyrimethanil（Pyrimethanil）It is the aminopyrimidine fungicide developed by German Ai Gefu companies.Pyrimethanil can prevent
The crops gray mold such as Yellow River harnessing melon, tomato, grape, strawberry, pea, leek.Can be additionally used in prevent pear scab, scab of apple and
Spot defoliation.
Propiconazole（Propiconazole）The triazole bactericidal agent developed by Syngenta Co., Ltd.Propiconazole can by root, stem,
Leaf portion absorbs, and can soon be conducted upwards in plant body.Propiconazole is had been described in US4079062；Its chemical constitution
For：
Have to improve to harmful fungoid in the case of the object of the present invention is to provide reducing in the application total amount of reactive compound and live
The composition of property（Synergistic composition）, to reduce the rate of application of known activity compound and improve its activity profile.
Invention content
It is an object of the present invention to provide a kind of bactericidal composition, just reduce rate of application and improve known compound propiconazole and phonetic
For the activity profile of mould amine, for the present invention in the case where the reactive compound of reduction applies total amount, having to harmful fungoid improves activity
Composition（It is synergistic）.
We have found that simultaneously, i.e., jointly or separately apply propiconazole and pyrimethanil or apply propiconazole and phonetic mould successively
Amine preferably to prevent harmful fungoid than each compound is administered alone.
The present invention provides a kind of bactericidal composition, the composition by the way that propiconazole and pyrimethanil are carried out binary built,
So that obtained composition has gain effect in control effect, and fungicidal spectrum is expanded, played the work that a medicine is mostly used
With effectively slowing down or germ avoided to develop immunity to drugs.Astoundingly, the bactericidal activity of bactericidal composition of the invention is than each
The adduction of the activity of reactive compound is considerably higher.In other words, there are unpredictable, necessary being synergistic effect, without
Only active supplement.
Various further investigations are passed through in invention, as a result, it has been found that the bactericidal composition containing propiconazole and pyrimethanil, it can anti-Zhiduo County
The fungoid and bacterial disease of kind veterinary antibiotics, fruit tree and cereal crop.Composition containing propiconazole and pyrimethanil is not
Only for common phytopathogen, and the pathogen that those have been generated with drug resistance is also highly effective, is continuously sent out in disease
Under the conditions of life also there is excellent control effect, thus complete the present invention.
When reactive compound is present in specific weight ratio in the bactericidal composition of the present invention, synergistic effect is especially bright
It is aobvious.But the weight ratio of the reactive compound in bactericidal composition can change in a certain range.
The bactericidal composition of the present invention plays synergy, suitable for prevention harmful fungoid and bacterium.And the present invention
Bactericidal composition particularly suitable for prevention Cereal, veterinary antibiotics, ornamental plant and the fungi in grapevine and bacteriosis.
The bactericidal composition of the present invention is particularly suitable for prevention Cereal, fruit, the fungi of vegetable storage phase and bacteriosis.
A kind of bactericidal composition of the present invention is that following technical scheme is taken to realize:
A kind of bactericidal composition, active constituent are made of propiconazole and pyrimethanil, and the weight ratio of the propiconazole and pyrimethanil is
10:1-1:50, more preferable 5:1-1:25, more preferable 5:1-1:20, further preferably 1:1-1:15, more preferable 1:5-1:15 weight
Than application.
Propiconazole and pyrimethanil separate administration or can be applied together or successively simultaneously；In separate administration
Sequence does not usually have any influence to the result of control measure.
Active constituent propiconazole and pyrimethanil can also be 10:1,9:1,8:1,7:1,6:1,5:1,4:1,3:1,2:1,1:
1,1:2,1:3,1:4,1:5,1:6,1:7,1:8,1:9,1:10,1:11,1:12,1:13,1:14,1:15,1:16,1:17,1:
18,1:19,1:20,1:21,1:22,1:23,1:24,1:25,1:26,1:17,1:28,1:29,1:30,1:31,1:32,1:
33,1:34,1:35,1:36,1:37,1:38,1:39,1:40,1:41,1:42,1:43,1:44,1:45,1:46,1:47,1:
48,1:49,1:50。
In the bactericidal composition, active constituent can be only included, can also also include filler and/or surface-active
Agent.
The bactericidal composition, dosage form is wettable powder, missible oil, suspending agent, suspension emulsion, microcapsules, seed coat agent, micro-
Emulsion, aqueous emulsion, water dispersible granules, foaming agent, paste, aerosol, ultra low volume liquids, ultra-low volume pulvis, granule, bubble
Rise piece.
The bactericidal composition, the wherein content of active constituent propiconazole and pyrimethanil account for the 1%- of bactericidal composition
90%, preferably 5%-80%, more preferable 10%-60%.
What the bactericidal composition, the wherein content of active constituent propiconazole and pyrimethanil accounted for bactericidal composition can be with
It is 1%, 3%, 5%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%,
24%, 25%, 26%, 27%, 28%, 29%, 30%, 31%, 32%, 33%, 34%, 35%, 36%, 37%, 38%, 39%, 40%, 41%, 42%,
43%, 44%, 45%, 46%, 47%, 48%, 49%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%.
The bactericidal composition is for preventing Cereal, veterinary antibiotics, fungi and bacterium on ornamental plant and grapevine
Purposes.
The bactericidal composition is for preventing Cereal, water fruits and vegetables, cotton, fruit tree, leaf spot, root on ornamental plant
Maize ear rot, downy mildew, penicilliosis, green mould, gray mold, sclerotiniose, brown rot, leaf spot, banded sclerotial blight, full rot, rust, anthrax
Disease, early blight, powdery mildew, scab, black spot, blight dis-ease, spot defoliation, stem wilt, ring spot, sour rot, crown rot,
Soft rot, mucormycosis, black spot, black rot, epidemic disease, the purposes of sclerotiniose.
The bactericidal composition is used to prevent the purposes of fruit or vegetable storage phase disease.
The bactericidal composition is used to protect fruit or vegetables stock in storage period from fungi or bacterial invasion
Purposes.
The bactericidal composition is used to prevent sour rot, penicilliosis, green mould, black rot, the base of a fruit during fruit, vegetable storage
Maize ear rot, burnt maize ear rot, anthracnose, crown rot, white epidemic disease, gray mold, brown rot, soft rot, mucormycosis, brown boiling hot disease, bitter pit, water
Worry, the purposes of black heart.
The bactericidal composition is used to prevent the purposes of storage diseases of orange.
The bactericidal composition is used to preventing orange storing phase anthracnose, sour rot, penicilliosis, green mould, burnt maize ear rot
Purposes.
A kind of method for preventing plant pathogen, pathogenic bacteria and/or its environment, Huo Zhezhi are acted on by bactericidal composition
In object, seed, soil, material or space, stock.
Bactericidal composition is applied in soil or cultivation medium by a kind of method for preventing plant pathogen.
A kind of method for preventing plant pathogen, propiconazole and pyrimethanil are administered simultaneously or are applied to pathogenic bacteria respectively
And/or in its environment or plant, seed, soil, material or space, stock.
A kind of method for preventing plant pathogen, bactericidal composition with seed treatment, foliage applying, stem is applied, is impregnated with,
The modes such as instillation, cast, injection, spraying, dusting, distribution or smoke are applied to pathogenic bacteria and/or its environment or plant, kind
Son, soil, material or space, stock.
It is a kind of to protect fruit or vegetables stock in storage period from fungi or the method for bacterial invasion, including making stock
It is contacted with the bactericidal composition of the present invention.
It is a kind of to protect fruit or vegetables stock in storage period from fungi or the method for bacterial invasion, including：（i）Harvesting
Before；（ii）After harvesting；Or（i）With（ii）When, the bactericidal composition of the present invention is contacted with fruit or vegetables.
Detailed description of the invention
The object of the present invention is to provide a kind of bactericidal composition, active constituent is made of propiconazole and pyrimethanil.Propiconazole and phonetic
The synergy of mould amine, propiconazole and pyrimethanil weight ratio can select in bigger range.
The weight ratio of propiconazole and pyrimethanil is 10:1-1:50, more preferable 5:1-1:25, more preferable 5:1-1:20, then it is excellent
Select 1:1-1:15, more preferable 1:5-1:15.
The weight ratio of active constituent propiconazole and pyrimethanil can also be：10:1,9:1,8:1,7:1,6:1,5:1,4:1,
3:1,2:1,1:1,1:2,1:3,1:4,1:5,1:6,1:7,1:8,1:9,1:10,1:11,1:12,1:13,1:14,1:15,1:
16,1:17,1:18,1:19,1:20,1:21,1:22,1:23,1:24,1:25,1:26,1:17,1:28,1:29,1:30,1:
31,1:32,1:33,1:34,1:35,1:36,1:37,1:38,1:39,1:40,1:41,1:42,1:43,1:44,1:45,1:
46,1:47,1:48,1:49,1:50。
The bactericidal composition of the present invention, the content of active constituent depend on dosage when sterilization is used alone, also depend on
A kind of fungicide and another mixed ratio of fungicide and synergistic effect degree.
The bactericidal composition, the wherein content of active constituent propiconazole and pyrimethanil account for the 1%- of bactericidal composition
90%, preferably 5%-80%, more preferable 10%-60%.
What the bactericidal composition, the wherein content of active constituent propiconazole and pyrimethanil accounted for bactericidal composition can be with
It is 1%, 3%, 5%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%, 22%, 23%,
24%, 25%, 26%, 27%, 28%, 29%, 30%, 31%, 32%, 33%, 34%, 35%, 36%, 37%, 38%, 39%, 40%, 41%, 42%,
43%, 44%, 45%, 46%, 47%, 48%, 49%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%.
In the bactericidal composition, active constituent can be only included, can also also include filler and/or surface-active
Agent.
The bactericidal composition of the present invention can be prepared into various dosage forms, such as wettable powder, missible oil, suspending agent, outstanding breast
Agent, microcapsules, seed coat agent, microemulsion, aqueous emulsion, water dispersible granules, foaming agent, paste, aerosol, ultra-low volume spray liquid.
According to the present invention, term " filler ", which refers to, can be combined with reactive compound or combines to make it easier for being administered to
Object（Such as plant, crop or careless class）Natural or synthetic organic or inorganic compound.Therefore, the filler is preferably
It is inert, it is acceptable at least to should be agricultural.The filler can be solid or liquid.
Liquid filler is usually：Water, alcohol type（Such as methanol, ethyl alcohol, isopropanol, butanol, ethylene glycol etc.）, ketone
（Such as acetone, methyl ethyl ketone, isobutyrone, cyclohexanone etc.）, ethers（Such as ether, dioxanes, methylcellulose,
Tetrahydrofuran etc.）, aliphatic hydrocarbon class（Such as kerosene, mineral oil etc.）, aromatic hydrocarbons class（Such as benzene,
Toluene, dimethylbenzene, solvent naphtha, alkylnaphthalene, chlorinated aromatic hydrocarbons, chlorinated aliphatic hydrocarbon, chlorobenzene, etc.）, halogenated hydrocarbon class, amide
Class, sulfone class, dimethyl sulfoxide (DMSO), mineral and vegetable oil, animal oil etc..
Solid-filling agent is usually：Phyteral powdery type（Such as soy meal, starch, grain dust, wood powder, bark powder, saw
End, walnut shell powder, wheat bran, cellulose powder, coconut husk, corncob and tobacco stem particle, extract the residue after plant essence
Deng）, paper, sawdust, crush synthesized polymer body, the clay class of synthetic resin etc.（Such as kaolin, bentonite, acid china clay etc.）、
Talcum powder class.Silica（Such as diatomite, silica sand, mica, aqueous silicic acid, calcium silicates）, activated carbon, natural mineral matter class（It is floating
Stone, attapulgite and zeolite etc.）, fire diatomite, sand, plastics medium etc.（Such as polyethylene, polypropylene, polyvinylidene chloride
Deng）, potassium chloride, calcium carbonate, the inorganic mineral powder of calcium phosphate etc., ammonium sulfate, ammonium phosphate, urea, greening ammonium etc. chemistry
Fertilizer, clay fertilizer, these substances can be used alone or two or more is mixed.
To make the emulsification of active ingredient compound, dispersion, solubilized and/or wetting that can use surfactant example
Fatty alcohol polyoxyethylene ether, polyoxyethylene alkylaryl ether, polyoxyethylene higher fatty acid esters, polyoxyethylene alcohol can such as be enumerated
Or the phosphate of phenol, the aliphatic ester of polyalcohol, alkyl aryl sulphonic acid, naphthalene sulfonic acid polymer, lignosulfonates, macromolecule comb
Branch shape copolymer, butyl naphthalene sulfonate, alkylaryl sulfonates, sodium alkylsulfosuccinates, grease, fatty alcohol and the epoxy of shape
The polyacrylates such as oxide condensate, alkyltaurate, protein hydrolysate.Suitable oligosaccharide object or polymer, such as
Based on individual vinyl monomer, acrylic acid, polyoxyethylene and/or polyoxypropylene or its with for example（It is polynary）Alcohol or（It is polynary）Amine
Combination.
The natural of tackifier such as carboxymethyl cellulose and powder, particle or latex form also can be used in preparation and close
Into polymer, such as gum arabic, polyvinyl alcohol and polyvinyl acetate or natural phospholipid, such as cephalin and lecithin,
And synthetic phospholipid.Other additives are mineral oil and vegetable oil.
The colorant that may be used such as inorganic pigment, for example, iron oxide, titanium oxide and Prussian blue and organic dyestuff, such as
Alizarin dyes, azo dyes or metal phthalein mountain valley with clumps of trees and bamboo dyestuff and trace nutrient, such as iron, manganese, boron, ketone, cobalt, molybdenum and zinc salt.
The disintegrant that may be used is selected from：Bentonite, urea, ammonium sulfate, aluminium chloride, citric acid, succinic acid, sodium bicarbonate
In it is one or more.
The stabilizer that may be used is selected from：One kind in sodium citrate, resorcinol.
The antifreezing agent that may be used is selected from：It is one or more in ethylene glycol, propylene glycol, glycerine, urea.
The antifoaming agent is selected from：Silicone oil, silicone compound, C10-20 Saturated fat acids compound, C8-10Fatty alcohol
It is one or more in class compound.
Optionally, also may include other annexing ingredients, for example, protecting colloid, adhesive, thickener, thixotropic agent, bleeding agent,
Stabilizer, screening agent.
The preparation of the present invention can be mixed the active constituent with filler and/or surfactant by known way
It closes and prepares, other conventional additives can be also added, such as drier and colorant, stabilizer, pigment, antifoaming agent, preservative, increasing
Thick dose etc..
The present invention bactericidal composition can also with other medicaments with weeding, desinsection or bactericidal property, particularly with
Protective fungicide is used in mixed way, and can also be mixed with insecticide, protective agent, growth regulator, nutrient for plants or soil conditioner
It closes and uses.
The bactericidal composition of the present invention has very strong activity to various phytopathogens, and can be to being drawn by phytopathogen
The prevention and treatment of the plant disease risen play very strong preventive effect.
The bactericidal composition of the present invention to such as Plasmodiophoromycetes, Oomycete, Chytridiomycetes, connect and Gammaproteobacteria, Ascomycetes, load
The wide scopes such as Gammaproteobacteria, deuteromycetes, Phycomycetes plant pathogenic fungi has excellent activity.
The bactericidal composition of the present invention also has extraordinary bactericidal performance, and it is thin to can be used for prevention plant pathogenic
Bacterium.Such as pseudomonadaceae, Rhizobiaceae, enterobacteriaceae, rod Cordycepps and Streptomycetaceae.
The bactericidal composition of the present invention is for preventing Cereal, veterinary antibiotics, fungi and thin on ornamental plant and grapevine
The purposes of bacterium.
The bactericidal composition of the present invention is suitable for preventing following phytopathogen：
Oomycetes subclass can be exemplified as, for example, various crops such as the pythium of black leg of beet bacterium (Pythiumultium)
Bacterium；Such as potato blight bacterium (Phytophthorainfestans), botrytis cinerea (Phytophthora capsici)
Phytophthora belongs to bacterium；Such as bacterium of downy mildew of cucumber (Pseudoperonospora cubensis), Humulus Pseudoperonospora cubensis
The Pseudoperonospora bacterium of (Pseudoperonospora humuli)；Such as Plasmopara viticola (Plasmopara viticola)
Plasmopara bacterium；Such as Pseudoperonospora cubensis (Peronospora brassicae), the onion mildew bacterium of brassicaceous vegetable
Peronospora bacterium of (Peronospora destructor), downy mildew of spinach bacterium (Peronospora spinaciae) etc..
Ascomycetes can be exemplified as, for example, the Erysiphe such as powdery mildew of cereals bacterium (Erysiphegraminis)
Bacterium；Such as the Sphaerotheca bacterium of greengrocery powdery mildew (Sphaerotheca fuliginea)；Such as apple black star bacteria (Venturia
Inaequalis), the Venturia bacterium of pear cucumerinum (Venturia nashicola)；Such as net blotch of barley bacterium
(Pyrenophorateres) Pyrenophora belongs to bacterium；Such as wheat class spot disease (Cochliobolus sativus)
Cochliobolus belongs to bacterium；Such as Sclerotinia bacterium of greengrocery hyphal cluster germ (Sclerotinia sclerotiorum).
Basidiomycetes can be exemplified as, for example, double spore rest fungus such as wheat leaf rust germ (Pucciniarecondita)
Belong to bacterium；Such as the Tilletia bacterium of bunt of wheat bacterium (Tilletiacaries)；Such as loose smut of barley bacterium (Ustilago
Nuda Ustilago bacterium) etc..
Deuteromycotina can be exemplified as, for example, the Phoma such as lucid asparagus Phoma asparagi Sacc (Phomaasparagi)
Bacterium；Such as the Septoria bacterium of wheat class crust blight bacterium (Septoria nodorum)；Such as Colletotrichumlagenarium
The Colletotrichum bacterium of (Colletotrichum lagenarium)；Such as wilt (Pyricularia oryzae)
Pyricularia belongs to bacterium；Such as the Botrytis bacterium of greengrocery ash arrhizus bacteria (Botrytis cinerea)；As apple spot is fallen leaves
Germ (Alternaria mali), the Alternaria bacterium of tomato early blight bacterium (Alternaria solani)；Such as beet Cercospora
The Cercospora bacterium of germ (Cercospora beticola)；Such as peach black star germ (Cladosporium carpophilum)
Blastocladia bacterium；Such as Rhizoctonia bacterium of Oryza sheath blight fungus (Rhizoctonia solani).
The bactericidal composition of the present invention is particularly suitable for preventing following plants disease fungus：
The two spore powdery mildews on standing grain powdery mildew (Erysiphe graminis), Curcurbitaceae on Cereal
(Erysiphecichoracearum) and the apple white powder on Siberian cocklebur monofilament shell (Sphaerotheca fuliginea), apple
On grape snag shell (Uncinula necator), Cereal on germ (Podosphaera leucotricha), grape
The smut on rhizoctonia (Rhizoctonia), Cereal and sugarcane on handle rest fungus (Puccinia), cotton, rice and lawn
(Ustilago), the venturia inaequalis on apple (Venturia inaequalis), the compacted spore bacterium of length on Cereal
(Helminthosporium), glume blight bacterium (Septorianodorum), strawberry, vegetables, ornamental plant and the grape on wheat
On botrytis cinerea (Botrytiscinera), the peanut tail spore bacterium (Cercospora arachidicola) on peanut, wheat and
The Magnaporthe grisea on eye spot bacterium (Pseudocercosporella herpotrichoides), rice on barley
On phytophthora infestans (Phytophthora infestans), grape on (Pyricularia oryzae), potato and tomato
Grape life uniaxial mould (Plasmoparaviticola), hops and Pseudocercosporella on cucumber, vegetables and
Alternaric bacteria (Alternaria) on fruit, spherical cavity bacterium (Mycosphaerella) and sickle-like bacteria on banana
(Fusarium) and verticillium sp (Verticillium).
The plant that bactericidal composition of the present invention is applicable in mainly includes：
Field crop, such as corn, soybean, cotton, rape oilseeds, such as southern general rape (Brassica napus) (such as rue
Tongue (canola)), overgrown with weeds green (Brassicarapa), leaf mustard (B.juncea) (such as mustard seed (mustard)) and Ethiopia
Mustard (Brassica carinata), rice, wheat, beet, sugarcane, oat, brown wheat, barley, broomcorn millet, triticale, flax；
Grapevine and the other fruit of various plants or vegetable crop, if the rose family (Rosaceaesp.) is (for example, pomaceous fruit water
Fruit, such as apple and pears, also drupe, such as apricot, cherry, almond and peach, berry such as strawberry), tea sugarcane scarabaeidae
(Ribesioidae sp.), Juglandaceae (Juglandaceae sp.), Betulaceae (Betulaceae sp.), Anacardiaceae
(Anacardiaceae sp.), Fagaceae (Fagaceae sp.), Moraceae (Moraceae sp.), Oleaceae (Oleaceae
Sp.), Actinidiaceae (Actinidaceae sp.), Lauraceae (Lauraceae sp.), Musaceae (Musaceae sp.) (such as
Banana tree and powder bajiao banana (plantings)), Rubiaceae (Rubiaceae sp.) (such as coffee), Theaceae (Theaceae
Sp.), Sterculiaceae (Sterculiceaesp.), Rutaceae (Rutaceae sp.) (such as lemon, orange and grape fruit)；Solanaceae
(Solanaceaesp.) (for example, tomato, potato, pepper, eggplant), Liliaceae (Liliaceae sp.), composite family
(Compositiae sp.) (such as lettuce, globe artichoke and witloof-including root witloof (root chicory), hare's-lettuce (endive)
Or common witloof (common chicory)), Umbelliferae (Umbelliferae sp.) (such as carrot, parsley, celery and block
Rooted celery), Curcurbitaceae (Cucurbitaceae sp.) (such as cucumber-include pickling cucumber (pickling cucumber), south
Melon, watermelon, cucurbit and muskmelon), green onion section (Alliaceae sp.) (such as onion and leek), Cruciferae (Cruciferae
Sp.) (such as white cabbage, red cabbage, broccoli, cauliflower, brussels sprout, green vegetables, kohlrabi, radish, horseradish, solely
Row dish, Chinese cabbage), pulse family (Leguminosaesp.) (such as peanut, pea and hyacinth bean-such as climning bean and broad bean), Chenopodiaceae
(Chenopodiaceae sp.) (such as fodder beet, spinach sweet tea (spinach beet), spinach, beet root), Malvaceae
(Malvaceae) (such as gumbo), Asparagaceae (Asparagaceae) (such as lucid asparagus)；
Garden crop and forest crop；
Ornamental plant；And the homologue of the genetic modification of these crops.
The bactericidal composition of the present invention is particularly suitable for fungi on prevention Cereal, veterinary antibiotics, ornamental plant and grapevine
And bacterium.
The bactericidal composition of the present invention is particularly suitable for root-rot on prevention Cereal, veterinary antibiotics, ornamental plant and grapevine
Disease, downy mildew, penicilliosis, green mould, gray mold, sclerotiniose, brown rot, leaf spot, banded sclerotial blight, full rot, rust, anthrax
Disease, early blight, powdery mildew, scab, black spot, blight dis-ease, spot defoliation, stem wilt, ring spot, sour rot, crown rot,
Soft rot, mucormycosis, black spot, black rot, epidemic disease, sclerotiniose.
The bactericidal composition of the present invention can also be used to prevent or control soil or cultivate a variety of pathogenic or saprophytic in medium
Fungi and bacterium.
The example of the aquacultural fungal pathogen of soil-borne includes Alternaria（Alternaria spp.）, Ascochyta
(Ascochyta spp.), Botrytis cinerea（Botrytis cinerea, Cercospora（Cercospora spp., ergot
（Clavicepspurpurea）, standing grain cochliobolus（Cochliobolussativus）, Colletotrichum（colletotrichum
Spp., Epicoccum（Epicoccum spp., F.graminearum schw（Fusariumgraminearum）, rice evil seedling chain spore
（Fusariummoniliforme）, fusarium oxysporum（Fusariumoxysporum, fusarium moniliforme
（Fusariumproliferatum）, fusariun solani (Fusariumsolani), dimension glue chain spore
(Fusariumsubglitinans), Helminthosporium (Helminthosporiumspp) avenges rotten microtorr bacterium
(Microdochiumnivale), Penicillium (Pencilliumspp), Phoma (Phoma spp.), wheat class nuclear cavity bacteria
(Pyrenophoragraminea), rice blast Pyricularia Sacc. (Pyriculariaoryzae), Rhizoctonia solani Kuhn
(Rhizoctoniasolani), Rhizoctonia cerealis (Rhizoctoniacerealis), Sclerotinia (Sclerotinia
Spp.), Septoria (Septoria spp.), silk axis smut (Sphacelothecareilliana), Tilletia
(Tilletia spp.), meat spore core coral bacterium (Typhula incarnate), hidden smut (Urocystisocculta) are black
Powder Pseudomonas (Ustilago spp.) or Verticillium (Verticillium spp.).
Soil germ has rhizoctonia solani, sickle-like bacteria, phytophthora, bacterium of dampinging off, root rot, pythium spp, botrytis cinerea, soft-rot fungi
Deng.Under normal circumstances, soil germ can generate a large amount of thalline, as long as condition is advantageous to pathogen growth development, host is sense
Disease, germ can amount reproduction can simultaneously infect host, in the presence of susceptible host, these germs can enter lasting
The phase of causing a disease, with the continuous cropping of crop, amount reproduction is spread, but nutrient is depleted or edaphic condition such as temperature, humidity etc. later
When unfavorable to germ, germ can enter rest period again.In the absence of susceptible host, soil-borne disease bacterium can also survive in the soil
Get off, in addition to soil germ has extensive host range, moreover it is possible to survive on the root surface of non-host or the broken branches and fallen leaves, with it
It is undivided with saprophytic competitiveness.But different germs are discrepant, as sickle-like bacteria in the soil almost can be unlimited
Phase survives.
The Fungicidai mixtures of the present invention can also be used to prevent storage period disease, and obtain unexpected synergy
Effect.
According to the present invention, after harvest and the disease of storage period can be for example by caused by following pathogen：
Colletotrichum kind, such as banana thorn disk spore (Colletotrichum musae), Colletotrichum gloeosporiodes
(Colletotrichum gloeosporioides), capsicum thorn disk spore (Colletotrichum coccodes)；
Fusarium kind, such as fusarium semitectum (Fusarium semitectum), fusarium moniliforme (Fusarium
Moniliforme), Fusarium solani (Fusarium solani), Fusarium oxysporum (Fusarium oxysporum)；
Verticillium dahliae belongs to kind, such as cocoa verticillium sp (Verticillium theobromae)；
Nigrospora belongs to kind；Botrytis kind, such as the pathogen of Botrytis cinerea (Botrytis cinerea)；
Geotrichum, such as geotrichum candidum (Geotrichum candidum)；
Phomopsis kind, Natal Phomopsis (Phomopsis natalensis)；
Diplodia kind, such as two spore of citrus color (Diplodia citri)；
Alternaria kind, for example, Altemaria citri (Alternaria citri), mutually every Alternariaspp (Alternaria
alternata)；
Phytophthora kind, such as phytophthora brown rot of citrus (Phytophthora citrophthora), strawberry phytophthora
(Phytophthora fragariae), Phytophthora cactorum (Phytophthora cactorum), Phytophthora nicotianae (Phytophthora
parasitica);
Septoria (Septoria spp.), such as Septoria depressa；
Mucor (Mucor spp.), such as pyriform Mucor (Mucor piriformis)；
Chain sclerotinia sclerotiorum belong (Monilinia spp.), such as fruit life chain sclerotinia sclerotiorum (Monilinia fructigena), drupe chain
Sclerotinite (Monilinia laxa)；
Venturia (Venturia spp.), such as venturia inaequalis (Venturia inaequalis), Pear scab
(Venturia pyrina)；
Rhizopus (Rhizopus spp.), such as rhizopus stolonifer (Rhizopus stolonifer), Rhizopus oryzae (Rhizopus
oryzae)；
It is small from shell category (Glomerella spp.), such as enclose small from shell (Glomerella cingulata)；Sclerotinia
(Sclerotinia spp.), such as the raw sclerotinite of fruit (Sclerotinia fruiticola)；
Long beak shell category (Ceratocystis spp.), such as unusual long beak shell (Ceratocystis paradoxa)；
Penicillium (Penicillium spp.), such as penicillium funiculosum (Penicillium funiculosum), penicillium expansum
(Penicillium expansum), Penicillium digitatum (Penicillium digitatum), Italian mould (Penicillium
italicum)；
The long spore category of disk (Gloeosporium spp.), such as the long spore of white disk (Gloeosporium album), Gloeosporium
Perennans, the fruit life long spore of disk (Gloeosporium fructigenum), Gloeosporium singulata；
Shell snake spore category (Phlyctaena spp.), such as Phlyctaena vagabunda；
Cylindrocarpon (Cylindrocarpon spp.), such as apple column spore (Cylindrocarpon mali)；Stemphylium
(Stemphyllium spp.), such as day lily stemphylium botryosum (Stemphyllium vesicarium)；
Star check shell spore category (Phacydiopycnis spp.), such as Phacydiopycnis malirum；Thiclaviopsis
(Thielaviopsis spp.), such as singular root string strain are mould (Thielaviopsis paradoxy)；
Aspergillus (Aspergillus spp.), such as aspergillus niger (Aspergillus niger), Aspergillus carbonerius (Aspergillus
carbonarius);
Nectria (Nectria spp.), such as the red shell bacterium of dry cancer clump (Nectria galligena)；
Stockless Peziza (Pezicula spp.).
It is sour rot during the bactericidal composition of the present invention is also particularly well suited for prevention fruit and vegetable storage, penicilliosis, green
It is mildew, black rot, blossom-end rot, burnt maize ear rot, anthracnose, crown rot, white epidemic disease, gray mold, brown rot, soft rot, mucormycosis, brown
Scald disease, bitter pit, black heart, soft rot.
The bactericidal composition of the present invention is used to prevent the purposes of fruit or vegetable storage phase disease.
The bactericidal composition of the present invention is used to protect fruit or vegetables stock in storage period from fungi or bacterial invasion
Purposes.
The bactericidal composition of the present invention is especially suitable for preventing storage diseases of orange.
The bactericidal composition of the present invention is especially suitable for prevention orange storing phase sour rot, penicilliosis, green mould, burnt corruption
Disease.
The present invention also provides it is a kind of prevent plant pathogen method, by bactericidal composition act on pathogenic bacteria and/or its
Environment or plant, plant propagation material and the plant organ then grown, soil, material or space, stock.
A kind of method for preventing plant pathogen, propiconazole and pyrimethanil are administered simultaneously or are applied to pathogenic bacteria respectively
And/or its environment or plant, plant propagation material and the plant organ then grown, soil, material or space, stock.
The present invention also provides it is a kind of prevent plant pathogen method, by the present invention bactericidal composition with seed treatment,
The modes such as foliage applying, stem are applied, are impregnated with, instiling, pouring into a mould, spraying, spraying, dusting, distribution or smoke be applied to pathogenic bacteria and/
Or its environment or plant, plant propagation material and the plant organ then grown, soil, material or space, stock.
The bactericidal composition of the present invention can be used as blade face fungicide in crop protection, can also be used as fungicide use
In seed dressing and as soil fungicide, can also adopt rear stock antisepsis antistaling agent.
The bactericidal composition of the present invention can handle all plants." plant " refers to all plants and plant population, such as manages
Wild plant think and undesirable, cultivated plant and plant variety are (regardless of whether by plant variety or plant cultivation human rights profit
Protection).Cultivated plant and plant variety can be the plants obtained by Sterile culture and breeding method, these methods can be auxiliary
With or be supplemented with one or more biological technique methods, such as use dihaploid, protoplast fusion, random prominent with orientation
Change, molecule or genetic marker use bioengineering and genetic engineering method.Plant part refers to all grounds and ground of plant
Lower part and organ, such as bud, leaf, Hua Hegen, such as leaf, needle, stem, branch, flower, fructification, fruit and seed and root,
Bulb and rhizome.Crop and nourish and generate and case of propagation material, for example, transplant, bulb, rhizome, running roots and seed also belong to
In plant part.
Term " plant propagation material " is interpreted as referring to all plant parts for having fertility, such as seed, can use
In breeding the latter and vegetable matter such as cuttage item or stem tuber（Such as potato）.Therefore, plant used herein
Part includes plant propagation material.It is mentioned that such as seed, root, fruit, stem tuber, bulb, rhizome and plant part.It treats
The germination plant and effective plant inhibited after germinateing from soil or after emergence.Young plant can be before transplantation by being impregnated into
Row whole or Local treatment are protected.
Currently preferred plant propagation material is seed.The bactericidal composition of the present invention is also particularly suitable for processing seed.
Crop damage caused by most harmful fungoid is due to during storage or after sowing and in plant germination process
Or caused by the infringement of the seed after germination.Since the root and branch of growth period plant are especially sensitive and even if small damage
It can result in the death of plant.This stage is particularly critical, because protecting seed and hair by using suitable composition
The plant of bud is extremely important.
Another aspect of the present invention provides a kind of method for protecting seed and germinating plants, and this method after planting or planting
Without additionally applying crop protection agents or at least significantly additionally applying crop protection agents after object germination.On the other hand, this is utilized
The amount of reactive compound used in the bactericidal composition optimization of invention, farthest to provide the guarantor of seed and germinating plants
Protect against plant pathogenic fungi invasion, and plant in itself will not by damaged using reactive compound.
Therefore, the present invention also more particularly to handles seed to protect seed and hair by using the bactericidal composition of the present invention
The method that bud plant invades from plant pathogenic fungi.The invention further relates to composition according to the present invention processing seed with
Protect seed and germinating plants from the purposes of plant pathogenic fungi.
Bactericidal composition according to the present invention is suitable for protection in agricultural, in greenhouse, in forestry or gardening-or vinegrowing
The seed of any plant variety of kind application.Particularly, the seed form used is cereal（Such as wheat, barley, rye, black
Wheat, millet, oat）, corn, cotton, soybean, rice, potato, sunflower, Kidney bean, coffee, beet, peanut, rape, olive
Olive, cocoa, sugarcane, tobacco, vegetables（Such as tomato, cucumber, onion and lettuce）, turfgrass and decoration use plant.Cereal and vegetable
The processing of the seed of vegetables is vital.
The present invention bactericidal composition in active constituent propiconazole and pyrimethanil individually or applied with suitable dosage form
For seed.The processing preferably in the state of substantially stabilized is so that processing will not cause any damage to seed.In general,
Random time point that can be between picking and sowing carries out processing seed.Commonly used seed detaches from plant and from fringe
Axis, shell, stem, epidermis, hair or pulp are isolated.Therefore, it is possible to use it for example, picked, cleaned and is dried low to water content
In 15% seed.Alternatively, it is also possible to for example with water process after using drying, the seed then dried once more.
The medicament of the method for seed treatment, such as can there are, diluent liquid or solid-like or without diluting directly general
Seed is immersed in the method that medicament is made to be impregnated with seed in liquid condition solution, is blended in solid chemicals or liquid preparation and seed
Together, it is coated the methods of processing makes the method for the surface of the seed attachment medicament, sprayed near seed while plantation.
Harm budding after plant plant pathogenic fungi control mainly by using crop protection agents processing soil and
The aerial part of plant carries out.
The bactericidal composition of the present invention can also be used to prevent or control soil or cultivate a variety of pathogenic or saprophytic in medium
Fungi and bacterium.The method of medicament is applied into soil, such as liquid preparation is diluted in water or do not diluted and is directly applied to
Granule is disseminated in the root of plant or the rice seedling bed of seedling by the methods of in the root of plant or the rice seedling bed of seedling
Method have the method that pulvis, water dispersible granules etc. are sprayed in soil prior to seeding and are integrally mixed with soil, before sowing
Or will be sprayed in implantation hole, seed furrow after pulvis, water-dispersible grain dilution agent before serike body, carrying out method of sowing
Deng.
The bactericidal composition of the present invention can also be used for protecting stock infecting from fungi and bacterium.
According to the present invention, term " stock " is understood as referring to have originated from natural life cycle and it is desirable that long-term preserve
Plant or animality source natural materials and its processed form.The stock of plant origin, such as plant or its portion
Point, it, can be with the state of fresh harvesting or with form processing such as (pre-) dry, profit such as stem, leaf, stem tuber, seed, fruit or seed
Wet, crushing, grinding, compacting or baking are protected.Can also be timber, thick timber form such as construction timber, electric pole and fence；
Or final product form, such as the furniture made of timber or article.The stock of animal origin is animal skin, leather, hair, hair etc..Root
The invasion such as burn into colour fading or mouldy of the fungi or bacterium of storage period can be prevented according to the composition of the present invention.It it is preferred that will " storage
Object " is understood as referring to the natural materials of plant origin and its form processing, more preferable fruit or vegetables, form processing.
Protect fruit or vegetables stock in storage period from fungi or the method for bacterial invasion the present invention also provides a kind of,
Including contacting stock and the bactericidal composition of the present invention.
Present invention offer is a kind of to protect fruit or vegetables stock in storage period from fungi or the method for bacterial invasion, packet
It includes：（i）Before harvesting；（ii）After harvesting；Or（i）With（ii）When, the bactericidal composition of the present invention is contacted with fruit or vegetables.
So bactericidal composition of the invention can be used as blade face fungicide in crop protection, can also be used as killing true
Microbial inoculum for dress seed and as soil fungicide, can also adopt rear stock antisepsis antistaling agent.
The bactericidal composition of the present invention can be applied by different processing methods, these methods are for example：
Liquid comprising the bactericidal composition is sprayed onto to the aerial part of the plant；
Dusting mixes particle or powder in the soil, is sprayed in the surrounding plants, and in tree injection or the situation of smearing
Under；
The seed of plant is coated or film coated.
When adopting rear anti-corrosive fresh-keeping for fruit or vegetables, 200-2000 times of liquid is usually diluted with water, is leached after soaking fruit.
The present invention provides a kind of method for preventing plant pathogen, can be treatment, prevention or method of eradication.
The bactericidal composition of the present invention can be made into common dosage form, such as missible oil, wettable powder, suspending agent, liquid
The dosage forms such as agent, granule, seed coat agent use, amount of application, according to the mixing ratio, meteorological condition, medicament of active ingredient
Form, Dressing date, method of administration, using place, prevent and kill off the different and variant of object noxious livings, objective crop etc..
Generally for leaf portion processing：0.1-10000g/ha, preferably 10-1000 g/ha, more preferable 50-500 g/ha；It is right
For dipping or application of instiling, the dosage can also even reduce, particularly when using inert base such as asbestos or pearl
During rock；
For seed treatment：2-5000g/100kg seeds, preferably 3-1000g/100kg seeds；
For soil or processing used for ponds：0.1-10000g/ha, preferably 1-1000g/ha.
It is fresh-keeping for postharvest fruit and vegetable, 200-2000 times of liquid can be diluted, is leached after soaking fruit.
Above-mentioned dosage is only general exemplary dose, and those skilled in the art can be according to practical feelings when reality is applied
Condition and needs adjust rate of application especially in accordance with the seriousness of the property and germ of pending plant or crop.
The propiconazole of the present invention combines/combined administration with pyrimethanil.Including separate, sequentially or simultaneously apply propiconazole with it is phonetic
Mould amine.Preferably, the propiconazole is combined as the form of the composition comprising propiconazole and pyrimethanil with pyrimethanil.
The composition of the present invention can be based on dosage form, i.e., each substance has mixed in composition；Composition into
Point can also unit dose form provide, mixed in bucket or tank using preceding, be then diluted to required concentration.Wherein preferably with this hair
Based on the dosage form of bright offer.
A kind of bactericidal composition advantage of the present invention：
The present invention provides a kind of bactericidal composition, the composition by propiconazole and pyrimethanil by carrying out binary built so that
Obtained composition has gain effect in control effect, and has expanded fungicidal spectrum, plays the role of a medicine and is mostly used, has
Effect slows down or germ is avoided to develop immunity to drugs.Astoundingly, the bactericidal activity of bactericidal composition of the invention is than each activity
The adduction of the activity of compound is considerably higher.In other words, there are unpredictable, necessary being synergistic effect, and not only
It is the supplement of activity.
A kind of bactericidal composition contains propiconazole and the bactericidal composition of pyrimethanil, can prevent various vegetables, fruit, fruit tree
With the fungoid and bacterial disease of cereal crop.Composition containing propiconazole and pyrimethanil is not only for common plant
Pathogen, and the pathogen that those have been generated with drug resistance is also highly effective, also has under the conditions of disease recurs excellent
Good control effect, thus complete the present invention.
Specific embodiment
Below with reference to embodiment, the invention will be further described：
Example of formulations：
+ 10% propiconazole wettable powder of 1 50% pyrimethanil of embodiment
Pyrimethanil 50%
Propiconazole 10%
Lauryl sodium sulfate 10%
Sodium lignin sulfonate 5%
White carbon 10%
Kaolin complements to 100%
By reactive compound, various auxiliary agents and filler etc. by formula proportional components mix, after ultra-fine pulverizer disintegrating to get
To+10% propiconazole wettable powder of 50% pyrimethanil.
+ 10% propiconazole wettable powder of 2 40% pyrimethanil of embodiment
Pyrimethanil 40%
Propiconazole 10%
Calcium dodecyl benzene sulfonate 1%
Sodium lignin sulfonate 2%
Sucrose complements to 100%
By reactive compound, various auxiliary agents and filler etc. by formula proportional components mix, after ultra-fine pulverizer disintegrating to get
To+10% propiconazole wettable powder of 40% pyrimethanil.
+ 10% propiconazole emulsifiable concentrate of 3 20% pyrimethanil of embodiment
Pyrimethanil 20%
Propiconazole 10%
Ethoxylated castor oil 5%
Calcium dodecyl benzene sulfonate 3%
Ethyl acetate complements to 100%
Mentioned component is proportionally prepared, is uniformly mixing to obtain uniform phase.
+ 1% propiconazole ultra low volume liquids of 4 5% pyrimethanil of embodiment
Pyrimethanil 5%
Propiconazole 1%
Polyoxyethylene alkylaryl ether 2%,
Ethyl acetate complements to 100%
+ 10% propiconazole water dispersible granules of 5 30% pyrimethanil of embodiment
Pyrimethanil 30%
Propiconazole 10%
MODIFIED LIGNOSULPHONATE 5%
Lauryl sodium sulfate 5%
Urea 5%
Kaolin complements to 100%
Pyrimethanil, propiconazole, dispersant, wetting agent, disintegrant and filler are uniformly mixed in the ratio of formula, by air-flow powder
It is broken into wettable powder；It adds a certain amount of water mixing extruding and makes material.+ 10% third ring of 30% pyrimethanil is obtained after dry sieve
Azoles water dispersible granules.
+ 10% propiconazole suspoemulsion of 6 50% pyrimethanil of embodiment
Oil phase：
Pyrimethanil 50%
Methyl oleate 10%
Ethoxylated castor oil 5%
Water phase：
Propiconazole 20%
The sodium salt 1% of naphthalene sulfonic acids-formaldehyde condensation products of sulfonation
Water complements to 100%
Propiconazole is dissolved in methyl oleate, ethoxylated castor oil is added in and obtains oil phase；According to formula by pyrimethanil, sulfonation
Naphthalene sulfonic acids-formaldehyde condensation products sodium salt, water is ground and/or high speed shear after obtain the suspending agent of pyrimethanil；It is stirring
It is lower that oil phase addition water phase is obtained into suspension emulsion.
+ 5% propiconazole emusion in water of 7 30% pyrimethanil of embodiment
Pyrimethanil 30%
Propiconazole 5%
Ethyl acetate 30%
Polyoxyethylene polyoxypropylene block polymer 8%
Ethylene glycol 5%
Water complements to 100%
Pyrimethanil, propiconazole, solvent, emulsifier etc. are added together, make to be dissolved into homogeneous oil phase；By water, antifreezing agent, antifoaming agent
Etc. mixing, into uniform water phase.Under high velocity agitation, water phase is added in into oil phase, aqueous emulsion can be made.
+ 5% propiconazole coated granule of 8 10% pyrimethanil of embodiment
Pyrimethanil 10%
Propiconazole 5%
Polyethylene glycol 3%
The silicic acid 1% of high degree of dispersion
Calcium carbonate complements to 100%
It in a mixer, will be on levigate Fungicidal active compound even spread to the carrier soaked by polyethylene glycol.With this side
Formula can obtain dust-free coated granules agent.
+ 10% propiconazole wettable powder of 9 50% pyrimethanil of embodiment
Pyrimethanil 50%
Propiconazole 10%
Lauryl sodium sulfate 1%
Sodium lignin sulfonate 1%
Kaolin complements to 100%
Said components are mixed in proportion, and grinds, crush, are prepared into wettable powder.
+ 5% propiconazole granule of 10 20% pyrimethanil of embodiment
Pyrimethanil 20%
Propiconazole 5%
Sodium lignin sulfonate 4%
Carboxymethyl cellulose 2%
Kaolin complements to 100%
Reactive compound is mixed and ground with auxiliary agent, is soaked with water, is granulated, then dries in the air stream.
+ 10% propiconazole seed coat agent of 11 20% pyrimethanil of embodiment
Pyrimethanil 20%
Propiconazole 10%
Fatty alcohol polyoxyethylene ether sulfosuccinic acid monoesters disodium 5%
MODIFIED LIGNOSULPHONATE 5%
Xanthans 1%
Bentonite 1%
Glycerine 5%
PVP-K30 1%
Water complements to 100%
Seed coat agent is obtained after above-mentioned each component is mixed ground and/or high speed shear in proportion.
+ 10% propiconazole microcapsule suspension-suspendinagent agent of 12 30% pyrimethanil of embodiment
Capsule core：
Propiconazole 10%
Plurafac LF1312(from BASF) 3%
Emulsogen 3510 (from Clariant) 1%
Capsule wall：
Lupranat®M20S(BASF Elastogran) 8%
DETA (BASF SE) 2%
Water phase：
Pyrimethanil 30%
ATLOX ®4913 (from Croda) 5%
Synperonic PE/64 3%
Xanthans 1%
Antifoaming agent 1%
Urea 1.0%
1,2- propylene glycol 3%
Methylisothiazolinone 2%
Catalyst 0.1%
Water complements to 100%
The oil phase addition that Lupranat M20S, propiconazole, Plurafac LF1312, Emulsogen 3510 are formed is contained
In the aqueous solution of DETA, ATLOX 4913, emulsion is formed.Then it heats and keeps the temperature 50oCatalyst reaction 2 is added under C
Hour.The microcapsules of propiconazole is obtained after cooling.
Synperonic PE/64 (from Croda), antifoaming agent, urea, pyrimethanil and water mix in proportion, and
Through being sanded, it is prepared into aqueous suspension agent.
Microcapsules containing propiconazole is added in the suspending agent of pyrimethanil, obtains the microcapsule suspension-suspendinagent agent of the present invention.
+ 5% propiconazole suspoemulsion of 13 25% pyrimethanil of embodiment
Pyrimethanil 25%
Propiconazole 5%
SOLVESSOTM200 5%
Ethoxylated castor oil 4%
Fatty alcohol polyoxyethylene ether sulfosuccinic acid monoesters disodium 5%
MODIFIED LIGNOSULPHONATE 5%
Xanthans 1%
Bentonite 1%
Glycerine 5%
Water complements to 100%
Propiconazole is dissolved in SOLVESSOTMIn 200, ethoxylated castor oil is added in, obtains the oil phase of propiconazole；
Fatty alcohol polyoxyethylene ether sulfosuccinic acid monoesters disodium, MODIFIED LIGNOSULPHONATE, pyrimethanil and water are mixed in proportion
It closes, the suspending agent of pyrimethanil is obtained after ground and/or high speed shear.
Oil phase containing propiconazole is added to the aqueous suspension agent of pyrimethanil-contain bactericide, obtains suspension emulsion.
+ 10% propiconazole water dispersible granules of 14 30% pyrimethanil of embodiment
Pyrimethanil 30%
Propiconazole 10%
MODIFIED LIGNOSULPHONATE 5%
Lauryl sodium sulfate 5%
Urea 5%
Kaolin complements to 100%
Pyrimethanil, propiconazole, dispersant, wetting agent, disintegrant and filler are uniformly mixed in the ratio of formula, by air-flow powder
It is broken into wettable powder；It adds a certain amount of water mixing extruding and makes material.+ 10% third ring of 30% pyrimethanil is obtained after dry sieve
Azoles water dispersible granules.
+ 20% propiconazole water dispersible granules of 15 20% pyrimethanil of embodiment
Pyrimethanil 20%
Propiconazole 20%
MODIFIED LIGNOSULPHONATE 5%
Lauryl sodium sulfate 5%
Urea 5%
Kaolin complements to 100%
Pyrimethanil, propiconazole, dispersant, wetting agent, disintegrant and filler are uniformly mixed in the ratio of formula, by air-flow powder
It is broken into wettable powder；It adds a certain amount of water mixing extruding and makes material.+ 20% third ring of 20% pyrimethanil is obtained after dry sieve
Azoles water dispersible granules.
+ 5% propiconazole wettable powder of 16 40% pyrimethanil of embodiment
Pyrimethanil 40%
Propiconazole 5%
Lauryl sodium sulfate 1%
Sodium lignin sulfonate 1%
Kaolin complements to 100%
Said components are mixed in proportion, and grinds, crush, are prepared into wettable powder.
+ 30% propiconazole of 17 70% pyrimethanil of embodiment
Pyrimethanil 70%
Propiconazole 30%
Said components are mixed, and be prepared into pulvis in proportion.
Proportioning in above example is weight per distribution ratio.
Biological test example
Toxicity Determination
Experiment one：The toxicity test of sigatoka
Using inhibition mycelial growth rate method：Experiment target is designated as sigatoka bacterium.
By propiconazole and pyrimethanil respectively with acetone solution, then with 0.1% the dilution of Tween-80 aqueous solution be configured to be
The liquid of row concentration draws 6mL to the conical flask of sterilizing, adds in 50 DEG C or so of potato Portugal respectively in superclean bench
Grape sugar agar medium（PDA）54mL pours into the plate of 4 diameter 9cm after shaking up, the toxic culture of 4 respective concentrations is made
Base；Toxic culture medium is made in the propiconazole of different ratio and pyrimethanil series concentration compound solution with same method.It will training
The sigatoka bacterium of 2 days is supported, fungus block is broken into colony edge with the card punch of diameter 5mm, is moved to fungus block with transfer needle pre-
The toxic PDA culture medium center being first configured to, is subsequently placed in 25 DEG C of incubators and cultivates, and often processing is repeated 4 times.After 3 days, use
Crossing method measures each processing colony diameter cm with slide calliper rule, and correction is obtained and inhibits percentage.Each bacterium colony right-angled intersection surveys two
A diameter represents bacterium colony size with its average.Then bacterium colony growth inhibition ratio is obtained as the following formula：
Then concentration EC in inhibiting is calculated with least square method50, then according to the abundant method calculating co-toxicity coefficients of Sun Yun（CTC）.
Table 1：To the virulence test result of sigatoka
As known from Table 1, the combination prevention sigatoka of propiconazole and pyrimethanil is in proportioning 10:1-1:When in 50 range, altogether
Malicious coefficient is all higher than 120, shows as synergistic effect.
Experiment two：The toxicity test of Penicillium italicum
Using inhibition mycelial growth rate method：Experiment target is designated as Penicillium italicum.
By propiconazole and pyrimethanil respectively with acetone solution, then with 0.1% the dilution of Tween-80 aqueous solution be configured to be
The liquid of row concentration draws 6mL to the conical flask of sterilizing, adds in 50 DEG C or so of potato Portugal respectively in superclean bench
Grape sugar agar medium（PDA）54mL pours into the plate of 4 diameter 9cm after shaking up, the toxic culture of 4 respective concentrations is made
Base；Toxic culture medium is made in the propiconazole of different ratio and pyrimethanil series concentration compound solution with same method.It will training
The Penicillium italicum bacterium of 2 days is supported, fungus block is broken into colony edge with the card punch of diameter 5mm, is moved to fungus block with transfer needle pre-
The toxic PDA culture medium center being first configured to, is subsequently placed in 25 DEG C of incubators and cultivates, and often processing is repeated 4 times.After 3 days, use
Crossing method measures each processing colony diameter cm with slide calliper rule, and correction is obtained and inhibits percentage.Each bacterium colony right-angled intersection surveys two
A diameter represents bacterium colony size with its average.Then bacterium colony growth inhibition ratio is obtained as the following formula：
Then concentration EC in inhibiting is calculated with least square method50, then according to the abundant method calculating co-toxicity coefficients of Sun Yun（CTC）.
Table 2：To the virulence test result of Penicillium italicum
As known from Table 2, the combination prevention Penicillium italicum of propiconazole and pyrimethanil, propiconazole and pyrimethanil are in proportioning 10:1-1:
When in 50 range, co-toxicity coefficient is all higher than 120, shows as synergistic effect.
Experiment three：To the toxicity test of citrus anthracnose
Using spore germination test method(s).The consistent citrus sapling of growing way is chosen, each processing selects 3 basins to be used for examination citrus sapling
Potter spray towers are sprayed under 50PSI pressure, and per basin about 5mL, each medicament sets 12 concentration gradients.Chemicals treatment
Connect bacterium for 24 hours afterwards, the sick leaf for having infected citrus anthracnose is uniformly shaken off conidium above citrus sapling is inoculated with, then
Citrus sapling is put into greenhouse and is cultivated.According to morbidity grade scale complete stool investigation disease index after 7d, and control effect is calculated,
Then concentration EC in inhibiting is calculated with least square method50, then according to the abundant method calculating co-toxicity coefficients of Sun Yun（CTC）.
Computational methods：
Survey toxicity index（ATI）=（Standard agent EC50/ reagent agent EC50）*100
Theoretical toxicity index（TTI）B in the percentage composition+B medicament toxicity index * mixtures of A in=A medicament toxicity index * mixtures
Percentage composition
Co-toxicity coefficient（CTC）=[mixture surveys toxicity index（ATI）/ mixture theoretical toxicity index（TTI）*100
CTC<80 be antagonism, and 80≤CTC≤120 are summation action, and CTC ＞ 120 are synergistic effect,
Table 3：To the virulence test result of citrus anthracnose
As known from Table 3, the combination prevention citrus anthracnose of propiconazole and pyrimethanil, propiconazole and pyrimethanil are in weight proportion 10:
1-1:When in 50 ranges, co-toxicity coefficient is all higher than 120, shows as synergistic effect.
Experiment four：To the toxicity test of Chinese cabbage bacterial soft rot
Using spore germination test method(s).The consistent Chinese cabbage plant of growing way is chosen, each processing selects 3 basins to be used for examination Chinese cabbage plant
Potter spray towers are sprayed under 50PSI pressure, and per basin about 5mL, each medicament sets 12 concentration gradients.Chemicals treatment
Connect bacterium for 24 hours afterwards, the sick leaf for having infected Chinese cabbage bacterial soft rot is uniformly shaken off conidium above Chinese cabbage plant connects
Kind, then Chinese cabbage plant is put into greenhouse and is cultivated.According to morbidity grade scale complete stool investigation disease index after 7d, and calculate anti-
Effect is controlled, concentration EC in inhibiting then is calculated with least square method50, then according to the abundant method calculating co-toxicity coefficients of Sun Yun（CTC）.
Computational methods：
Survey toxicity index（ATI）=（Standard agent EC50/ reagent agent EC50）*100
Theoretical toxicity index（TTI）B in the percentage composition+B medicament toxicity index * mixtures of A in=A medicament toxicity index * mixtures
Percentage composition
Co-toxicity coefficient（CTC）=[mixture surveys toxicity index（ATI）/ mixture theoretical toxicity index（TTI）*100
CTC<80 be antagonism, and 80≤CTC≤120 are summation action, and CTC ＞ 120 are synergistic effect,
Table 4：To the virulence test result of Chinese cabbage bacterial soft rot
As known from Table 4, the combination prevention Chinese cabbage bacterial soft rot of propiconazole and pyrimethanil, propiconazole and pyrimethanil are matched in weight
Than 10:1-1:When in 50 ranges, co-toxicity coefficient is all higher than 120, shows as synergistic effect.
Experiment five：The toxicity test of citrus sour rot
Using inhibition mycelial growth rate method：Experiment target is designated as citrus sour rot.
By propiconazole and pyrimethanil respectively with acetone solution, then with 0.1% the dilution of Tween-80 aqueous solution be configured to be
The liquid of row concentration draws 6mL to the conical flask of sterilizing, adds in 50 DEG C or so of potato Portugal respectively in superclean bench
Grape sugar agar medium（PDA）54mL pours into the plate of 4 diameter 9cm after shaking up, the toxic culture of 4 respective concentrations is made
Base；Toxic culture medium is made in the propiconazole of different ratio and pyrimethanil series concentration compound solution with same method.It will training
The citrus sour rot bacterium of 2 days is supported, fungus block is broken into colony edge with the card punch of diameter 5mm, is moved to fungus block with transfer needle pre-
The toxic PDA culture medium center being first configured to, is subsequently placed in 25 DEG C of incubators and cultivates, and often processing is repeated 4 times.After 3 days, use
Crossing method measures each processing colony diameter cm with slide calliper rule, and correction is obtained and inhibits percentage.Each bacterium colony right-angled intersection surveys two
A diameter represents bacterium colony size with its average.Then bacterium colony growth inhibition ratio is obtained as the following formula：
Then concentration EC in inhibiting is calculated with least square method50, then according to the abundant method calculating co-toxicity coefficients of Sun Yun（CTC）.
Table 5：To the virulence test result of citrus sour rot
As known from Table 5, the combination prevention citrus sour rot of propiconazole and pyrimethanil, propiconazole and pyrimethanil are in proportioning 10:1-1:
When in 50 range, co-toxicity coefficient is all higher than 120, shows as synergistic effect.
Claims (16)
1. a kind of bactericidal composition, which is characterized in that active constituent is made of propiconazole and pyrimethanil, the propiconazole and phonetic mould
The weight ratio of amine is 10:1-1:50, more preferable 5:1-1:25, more preferable 5:1-1:20, further preferably 1:1-1:15, more preferable 1:5-
1:15。
2. bactericidal composition according to claim 1, which is characterized in that also comprising filler and/or surfactant.
3. bactericidal composition according to claim 1, which is characterized in that dosage form for wettable powder, missible oil, suspending agent,
Suspension emulsion, microcapsules, seed coat agent, microemulsion, aqueous emulsion, water dispersible granules, foaming agent, paste, aerosol, ultra-low volume liquid
Agent, ultra-low volume pulvis, granule, effervescent tablet.
4. bactericidal composition according to claim 1, which is characterized in that wherein active constituent propiconazole and pyrimethanil contains
Amount accounts for the 1%-90%, preferably 5%-80%, more preferable 10%-60% of bactericidal composition.
5. bactericidal composition described in claim 1 is true on Cereal, veterinary antibiotics, ornamental plant and grapevine for preventing
Bacterium and the purposes of bacterium.
6. bactericidal composition described in claim 1 is used to prevent leaf spot, root rot, downy mildew, penicilliosis, green mould, grey mold
Disease, sclerotiniose, brown rot, leaf spot, banded sclerotial blight, full rot, rust, anthracnose, early blight, powdery mildew, scab, blackspot
Disease, blight dis-ease, spot defoliation, stem wilt, ring spot, sour rot, crown rot, soft rot, mucormycosis, black spot, black rot,
Epidemic disease, the purposes of sclerotiniose.
7. bactericidal composition described in claim 1 is used to prevent the purposes of fruit or vegetable storage phase disease.
8. bactericidal composition described in claim 1 is used to protect fruit or vegetables stock in storage period from fungi or bacterium
The purposes infected.
9. bactericidal composition described in claim 1 is for sour rot during preventing fruit, vegetable storage, penicilliosis, green mould, black
Maize ear rot, blossom-end rot, burnt maize ear rot, anthracnose, crown rot, white epidemic disease, gray mold, brown rot, soft rot, mucormycosis, brown boiling hot disease, hardship
Acne disease, water core, black heart purposes.
10. bactericidal composition described in claim 1 is used to prevent the purposes of storage diseases of orange.
11. bactericidal composition described in claim 1 is used to prevent orange storing phase anthracnose, sour rot, penicilliosis, green mold
The purposes of disease, burnt maize ear rot.
A kind of 12. method for preventing plant pathogen, which is characterized in that including bactericidal composition described in claim 1 is made
For in pathogenic bacteria and/or its environment or plant, seed, soil, material or space, stock.
A kind of 13. method for preventing plant pathogen, which is characterized in that propiconazole described in claim 1 and pyrimethanil is same
When apply or be applied to pathogenic bacteria respectively and/or its environment or plant, seed, soil, material or space, stock in.
A kind of 14. method for preventing plant pathogen, which is characterized in that by bactericidal composition described in claim 1 with seed
The modes such as processing, foliage applying, stem are applied, are impregnated with, instiling, pouring into a mould, spraying, spraying, dusting, distribution or smoke are applied to pathogenic
Bacterium and/or its environment or plant, seed, soil, material or space, stock.
15. a kind of protect fruit or vegetables stock in storage period from fungi or the method for bacterial invasion, which is characterized in that packet
Including makes stock be contacted with bactericidal composition described in claim 1.
16. a kind of protect fruit or vegetables stock in storage period from fungi or the method for bacterial invasion, which is characterized in that packet
It includes：（i）Before harvesting；（ii）After harvesting；Or（i）With（ii）When, by bactericidal composition described in claim 1 and fruit or vegetables
Contact.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109730076A (en) * | 2019-02-19 | 2019-05-10 | 山东省果树研究所 | A kind of bactericidal composition and its application containing difenoconazole and pyrimethanil |
| CN115211460A (en) * | 2022-06-09 | 2022-10-21 | 凡美(广州)农业科技有限公司 | Preservative for oranges |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004036996A1 (en) * | 2002-10-24 | 2004-05-06 | Bayer Cropscience S.A. | Use of pyrimethanil on resistant pathogens |
| CN102106349A (en) * | 2009-12-23 | 2011-06-29 | 中国中化股份有限公司 | Antifungal composition containing tebuconazole and pyrimidine compound |
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2016
- 2016-12-30 CN CN201611258113.7A patent/CN108260593B/en active Active
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004036996A1 (en) * | 2002-10-24 | 2004-05-06 | Bayer Cropscience S.A. | Use of pyrimethanil on resistant pathogens |
| CN102106349A (en) * | 2009-12-23 | 2011-06-29 | 中国中化股份有限公司 | Antifungal composition containing tebuconazole and pyrimidine compound |
Non-Patent Citations (1)
| Title |
|---|
| 刘长令: "《世界农药大全杀菌剂卷》", 31 January 2008 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109730076A (en) * | 2019-02-19 | 2019-05-10 | 山东省果树研究所 | A kind of bactericidal composition and its application containing difenoconazole and pyrimethanil |
| CN115211460A (en) * | 2022-06-09 | 2022-10-21 | 凡美(广州)农业科技有限公司 | Preservative for oranges |
| CN115211460B (en) * | 2022-06-09 | 2024-05-24 | 凡美(广州)农业科技有限公司 | Preservative for citrus |
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