CN108522516A - A kind of bactericidal composition - Google Patents
A kind of bactericidal composition Download PDFInfo
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- CN108522516A CN108522516A CN201710118772.9A CN201710118772A CN108522516A CN 108522516 A CN108522516 A CN 108522516A CN 201710118772 A CN201710118772 A CN 201710118772A CN 108522516 A CN108522516 A CN 108522516A
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- Prior art keywords
- plant
- bactericidal composition
- tetraconazole
- cyano
- amino
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/64—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with three nitrogen atoms as the only ring hetero atoms
- A01N43/647—Triazoles; Hydrogenated triazoles
- A01N43/653—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01C—PLANTING; SOWING; FERTILISING
- A01C1/00—Apparatus, or methods of use thereof, for testing or treating seed, roots, or the like, prior to sowing or planting
- A01C1/06—Coating or dressing seed
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01G—HORTICULTURE; CULTIVATION OF VEGETABLES, FLOWERS, RICE, FRUIT, VINES, HOPS OR SEAWEED; FORESTRY; WATERING
- A01G13/00—Protecting plants
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
Abstract
The present invention provides a kind of bactericidal composition, the bactericidal composition active constituent is made of 2-cyano-3-amino-3-phenylancryic acetate and tetraconazole, and the weight ratio of the 2-cyano-3-amino-3-phenylancryic acetate and tetraconazole is 50:1‑1:1.The bactericidal composition of the present invention is particularly suitable for Fusarium on control Cereal, veterinary antibiotics, ornamental plant and grapevine（Fusarium) disease and Erysiphe（Erysiphe) disease.
Description
Technical field
The present invention relates to a kind of bactericidal compositions, further relate to a kind of method of prevention plant pathogen.
Background technology
About pesticide activity, especially to crop protection, one of the key problem of research carried out in the technical field is
Improve the performance in terms of performance, especially bioactivity and the performance in terms of keeping this activity within a certain period of time.
2-cyano-3-amino-3-phenylancryic acetate belongs to 2- cyanoacrylate fungicide, and structural formula is 2- cyano -3- amino -3- phenylacrylic acids
Ethyl ester.2-cyano-3-amino-3-phenylancryic acetate is a kind of structure novel, and the unique new type bactericide of the mode of action all has a variety of pathogens higher
Bactericidal activity especially causes head blight to reaping hook mushroom, caused by bakanae disease of rice, Fusarium oxysporum caused by fusarium moniliforme
Cucurbits fusarium wilt is effective, has protective effect and therapeutic effect.It is absorbed by root, there is upward translocatable, face on blade
To blade lower part and interlobate translocatable poor.But its exclusive use is also easy to produce drug resistance, and conductibility is general, to high true
Bacterium activity is general.
Tetraconazole（Tetraconazole）, chemical name：2- (2,4 dichloro benzene base) -3- (1H-1,2,4- triazoles -1-
Base) propyl 1,1,2,2 ,-tetrafluoro ethylether, as known to EP234242 with fungicide.Structural formula is：
Tetraconazole belongs to second generation triazole bactericidal agent, fluorine-containing in molecular structure, wide sterilization spectrum, efficiently, the lasting period be up to 4-6
Week has protection and therapeutic effect, and has good Uptake and translocation performance.Suitable for crop cereal crop such as wheat, barley, swallow
Wheat, rye etc., fruit tree such as banana, grape, pears, apple etc., vegetables are for example melon, beet, ornamental plant etc..Powdery mildew can be prevented
Category, Puccinia, beak genuss, disease caused by the genus nucleosus and cyclosporin such as wheat powdery mildew, loose smut of wheat, small
Wheat rust, the bunt of wheat, wheat yinghu disease, barley leaf blotch, loose smut of barley, barley banded sclerotial blight, maize head dust-brand
Disease, head smut of sorghum, melon and fruit powdery mildew, sigatoka, alternaria leaf spot of apple, pear scab and uncinula necator etc..
Both can cauline leaf process, can also make seed treatment use.
A kind of long-term reactive compound of single administration, which carrys out controlling disease, to cause disease drug resistance to generate, and cause compound anti-
Effect declines, or even thoroughly loses preventive effect.In order to reduce the risk that phytopathogen develops immunity to drugs, prevented using synergistic composition
Noxious plant disease fungus be at present frequently with one of method.
Invention content
The object of the present invention is to provide a kind of bactericidal compositions, have improved activity and reactive compound to harmful fungoid
Total amount of application reduce composition（It is synergistic）, to reduce rate of application and improve the activity profile of known compound.
We have found that be administered simultaneously, i.e., apply or be administered alone together compound 2-cyano-3-amino-3-phenylancryic acetate and tetraconazole or successively
The harmful fungoid preventive and therapeutic effect provided using 2-cyano-3-amino-3-phenylancryic acetate and tetraconazole is got well than the effect of each compound is administered alone.
The present invention provides a kind of bactericidal compositions, by the way that 2-cyano-3-amino-3-phenylancryic acetate and tetraconazole to be combined so that obtain
Composition there is gain effect in control effect, and expanded fungicidal spectrum, effectively slowed down or germ is avoided to generate anti-medicine
Property.
Astoundingly, the bactericidal activity of bactericidal composition of the invention is brighter than the active adduction of each reactive compound
Aobvious higher；There are unpredictable, necessary being synergistic effects, rather than just active supplement.
When reactive compound is present in specific weight ratio in the bactericidal composition of the present invention, synergistic effect is especially bright
It is aobvious.But the weight ratio of the reactive compound in bactericidal composition of the present invention can change in a certain range.
The present invention provides a kind of bactericidal composition, and active constituent is made of 2-cyano-3-amino-3-phenylancryic acetate and tetraconazole, the cyanogen alkene bacterium
The weight percent of ester and tetraconazole is 50:1-1:1, preferably 40:1-1:1, more preferable 30:1-1:1, more preferable 25:1-1:
1, further preferably 20:1-1:1, more preferable 15:1-5:1, more preferable 15:1-8:1 weight ratio application.
In the present invention, the weight proportion of 2-cyano-3-amino-3-phenylancryic acetate and tetraconazole can also be 50:1,49:1,48:1,47:1,46:
1,45:1,44:1,43:1,42:1,41:1,40:1,39:1,38:1,37:1,36:1,35:1,34:1,33:1,32:1,31:1,
30:1,29:1,28:1,27:1,26:1,25:1,24:1,23:1,22:1,21:1,20:1,19:1,18:1,17:1,16:1,
15:1,14:1,13:1,12:1,11:1,10:1,9:1,8:1,7:1,6:1,5:1,4:1,3:1,2:1,1:1。
A kind of bactericidal composition, active constituent are made of 2-cyano-3-amino-3-phenylancryic acetate and tetraconazole, also include filler and/or surface
Activating agent.
The bactericidal composition dosage form is suspending agent, seed coat agent, suspension emulsion, wettable powder, water dispersible granules, micro-capsule
Suspending agent, coated granule squeeze out granule, missible oil, microemulsion, aqueous emulsion, effervescent tablet, ultra low volume liquids, dry suspension.
The content of the active constituent of the bactericidal composition, wherein 2-cyano-3-amino-3-phenylancryic acetate-containing and tetraconazole accounts for composition
5%-90%, preferably 10%-80%, more preferable 20%-70%.
In the bactericidal composition of the present invention, the quality of 2-cyano-3-amino-3-phenylancryic acetate and tetraconazole accounts for the bactericidal composition by weight
Can also be, for example, 5%, 6%, 7%, 8%, 9%, 10%, 11%, 12%, 13%, 14%, 15%, 16%, 17%, 18%, 19%, 20%, 21%,
22%,23%,24%,25%,26%,27%,28%,29%,30%,31%,32%,33%,34%,35%,36%,37%,38%,39%,40%,
41%,42%,43%,44%,45%,46%,47%,48%,49%,50%,51%,52%,53%,54%,55%,56%,57%,58%,59%,
60%,61%,62%,63%,64%,65%,66%,67%,68%,69%,70%,71%,72%,73%,74%,75%,76%,77%,78%,
79%,80%,81%,82%,83%,84%,85%, 86%,87%,88%,89%,90%。
A method of prevention plant pathogen, by the present invention bactericidal composition act on plant pathogen and/or its
Environment or plant, plant part, plant propagation material and the plant organ then grown, soil or cultivation medium, material or
In space.
A method of bactericidal composition of the present invention is acted on plant or plant portion by prevention plant pathogen
Point.
A method of prevention plant pathogen, by bactericidal composition of the present invention act on plant propagation material and
The plant organ then grown.
A method of bactericidal composition of the present invention is acted on soil or cultivation matchmaker by prevention plant pathogen
It is situated between.
A method of 2-cyano-3-amino-3-phenylancryic acetate and tetraconazole are administered simultaneously or apply respectively or phase by prevention plant pathogen
After application.
A method of prevention plant pathogen, can plant by before infecting or after infecting by the Bactericidal composite
Object acts on plant pathogen and/or its environment or plant, plant part, plant propagation material and the plant then grown
In organ, soil or cultivation medium, material or space.
A method of prevention plant pathogen includes with agronomy by the bactericidal composition of the present invention effectively and substantially without plant
The amount of application of object toxicity applied with seed treatment, foliage applying, stem, is impregnated with, instiled, poured into a mould, sprayed, sprayed, dusting, distribution or
The methods of smoke is applied to plant pathogen and/or its environment or plant, plant part, plant propagation material and subsequent length
In the plant organ, soil or cultivation medium, material or the space that go out.
The bactericidal composition is for preventing Cereal, veterinary antibiotics, fungi and bacterium on ornamental plant and grapevine
Purposes.
Purposes of the bactericidal composition for protecting plant, plant propagation material and the plant organ then grown.
The bactericidal composition is applied to pathogenic or saprophytic in the required place prevention soil prevented or cultivation medium
The purposes of fungi and bacterium.
The bactericidal composition is used to handle seed the purposes invaded with the phytopathogen for protecting seed to carry.
The bactericidal composition is used to protect the purposes of the fruits and vegetables after harvest.
The bactericidal composition is for protecting stock in storage period from fungi or the purposes of bacterial invasion.
The bactericidal composition of the present invention has very strong activity to various phytopathogens, and can be to being drawn by phytopathogen
The prevention and treatment of the plant disease risen play very strong preventive effect.
The bactericidal composition of the present invention plants the wide scopes such as such as Basidiomycetes, Ascomycetes, Oomycete and deuteromycetes
Object pathogenic epiphyte has excellent activity.
Oomycete, including Phytophthora（), such as phytophthora infestans Phytophthora
(Phytophthorainfestans), phytophthora sojae kaufmann＆gerdemann（Phytophthoramegasperma), foot rot of citrus bacterium
（Phytophthoraparasitica), camphor tree phytophthora（) and phytophthora capsici Phytophthoracinnamomi
(Phytophthoracapsici) disease；Careless rotten mould withered category（Pythium) such as level ground grass Pythium aphanidermatu
（Pythiumaphanidermatum disease)；And Peronosporaceae（Peronosporaceae) disease such as Plasmopara viticola
（Plasmoparaviticola), peronospora（Peronospora）（Including Peronosporatabacina
（) and Peronospora parasitic bacterium Peronosporatabacina（Peronosporaparasitica)), Pseudoperonospora
(Pseudoperonospora belongs to）Germ（Including bacterium of downy mildew of cucumber（Pseudoperonosporacubensis) and disk stalk is mould
Bacterium germ（Bremialactucae), pythium（Pythium）Such as scraping and printing unit（Pythiumaphanidermatum);
Ascomycetes, including Alternaria（Alternaria) disease such as tomato early blight bacterium（Alternariasolani) and
Black spot of cabbage bacterium（Alternariabrassicae), ball seat Pseudomonas (Guignardia) disease such as black rot of grape bacterium
（Guignardiabidwelli), Venturia（Venturia) disease such as apple black star bacteria
（Venturiainaequalis), Septoria（Septoria) disease such as glume blight bacterium (Septorianodorum) and leaf
Blight bacterium（Septoriatritici), powdery mildew such as Erysiphe（Erysiphe) (including wheat powdery mildew
（) and trailing plants Powdery Mildew Erysiphegraminis（Erysiphepolygoni)), grape powdery mildew
（Uncinulanecatur), cucumber powdery mildew's pathogen（) and apple mildew bacterium Sphaerothecafuligena
(Podosphaeraleucotricha), wheat Phyllostachys pubescens（Pseudocercosporellaherpotrichoides) object
Kind, grey mold Pseudomonas（Botrytis) species disease such as Botrytis cinerea germ（Botrytiscinerea), Monilinia fructicola
（Moniliniafructicola) disease, sclerotium Pseudomonas（Sclerotinia) species disease such as Sclerotinia sclerotiorum
（Sclerotiniasclerotiorum), Pyricularia oryzae（Magnaporthegrisea), grape branch-rot bacterium
(Phomopsisviticola) disease, compacted shape Pseudomonas（Helminthosporium) species disease such as Exserohilum turcicum
(Helminthosporiumtriticirepentis), reticulate pattern germ（Pyrenophorateres) species, anthrax disease is for example
Black fruit bacterium（) or colletotrichum Glomerella（Colletotrichum belongs to）Disease（Such as fine strain of millet anthrax bacteria
(Colletotrichumgraminicola) and watermelon anthrax bacteria（Colletotrichumorbiculare)) and wheat is complete
Lose germ（Gaeumannomycesgraminis);
Basidiomycetes, including by Rust（Puccinia belongs to）Caused by rest fungus disease（Such as Puccinia recondita
（Pucciniarecondita), strip rust bacteria（Pucciniastriiformis), leaf rust（Pucciniahordei), puccinia graminis bacterium
（) and handle rest fungus Pucciniagraminis（Pucciniaarachidis)), coffee rest fungus（Hemileiavastatrix) and
Phakopsora pachyrhizi sydow（Phakopsorapachyrhizi);
Deuteromycetes, including Rhizoctonia（Rhizoctonia belongs to）Species（Such as Rhizoctonia solani Kuhn
（) and redness of the skin or complexion hyphal cluster germ Rhizoctoniasolani（Rhizoctoniaoryzae));Fusarium（Fusarium) disease,
Such as F.graminearum schw（Fusariumgraminearum）, beads Fusariumsp（Fusariummoniliforme）, fusarium oxysporum
（Fusariumoxysporum, fusarium moniliforme（Fusariumproliferatum）, fusariun solani
(Fusariumsolani);Verticillium dahliae（Verticilliumdahliae);Sclerotiumrolfsii（Sclerotiumrolfsii)；Cloud
Line bacterium（Rynchosporiumsecalis);Black puckery germ (Cercosporidiumpersonatum), alternaria
（) and brown patch germ Cercosporaarachidicola（Cercosporabeticola);Silver dollar pinta bacterium
(Rutstroemiafloccosum)。
The crop plants that the bactericidal composition of the present invention is suitable include mainly：Cereal crops, for example, wheat, barley, oat,
Naked barley, triticale, rice, corn, sorghum and millet；Vine crop, such as Table Grape and vinifera；Field crop, example
Such as rape（Canola）, sunflower；Sugar beet, sugarcane, soybean, peanut（Peanut）, tobacco, clover, clover, Hu Zhi
Son, clover and vetch；Pip fruit, such as apple, pears, crabapple, loquat, hawthorn and quince；Stone fruit, example
Such as peach, cherry, plum, apricot, honey peach；Citrus fruit, such as lemon, bitter orange, orange, shaddock, mandarin orange（Orange）And kumquat；
Radicant and field crop（And their leaf）, such as arithoke, common beet and sugar beet, carrot, cassava, life
Ginger, ginseng, horseradish, parsnip, potato, little radish, turnip, sweet potato, turnip and Chinese yam；Bulb bearing plant, such as
Garlic, leek, onion and verdant；Leaf vegetables plant, such as mustard seed bitter dish（Rocket salad）, celery, celery, Chinese celery, witloof（Thatch dish）、
Fennel, bile ingredients and leaf lettuce, parsley, red witloof（Red witloof）, rheum officinale, spinach and Swiss chard；Btassica（Koryo
Dish）Leaf vegetables, such as broccoli, cauliflower（Broccoli）, it is Brussels sprouts, cabbage, Chinese cabbage, cauliflower, wild cabbage, collard, big
Head dish, leaf mustard and green vegetables；Bean（It is succulence or without juice）Such as lupin, Kidney bean）（Including broad bean, kidney bean, dish
Beans, Hua Dou, scarlet runner bean, snap beans, wide leaf vegetables beans and wax bean）, Kidney bean（Vigna belongs to）(including red bean, long cowpea
Beans, cow gram, black cowpea, fresh kidney beans, cowpea, mung bean, cowpea, urd bean and speciality cowpea）, broad bean, chick-pea, melon ear, sword bean, soldier
Beans and pea（Pisum belongs to））(including kidney bean, edible podded pea, field pea, pea, green pea, snow bean, sweet tea beans, pigeonpea and
Soybean）；Fruit vegetables, such as eggplant, ground-cheery（Physalis belongs to）, Solanum muicatum and capsicum（Including bell pepper, capsicum, for cooking
Capsicum, pimiento, pimento；Small tomato and tomato）；Cucurbit class vegetables, such as chocho（Fruit）, wax gourd, citron watermelon, Huang
Melon, young cucumber, marrow squash（Including cucurbit, lagenaria sicerariae）, sponge gourd, gumbo, balsam apple, dioecism momordica root, balsam pear and Chinese cucumber, perfume (or spice)
Melon, cucurbita pepo and winter squash and watermelon；Berries, such as blackberry, blueberry, the red fruit certain kind of berries, dew the certain kind of berries, the purplish blue certain kind of berries, blueberry, Cranberry, currant,
The wild certain kind of berries, Loganberry, raspberry and strawberry；The raw nut of tree, for example, almond, beech nut, Brazil nut, butternut, cashew nut, Chinese chestnut,
Fibert（Filbert）, hickory nut, Queensland nut, pecan and English walnut；Tropical fruit (tree) and other crops, for example, banana, plantain,
Mango, coconut, pawpaw, avocado, lichee, American aloe, coffee, cocoa, sugarcane, oil palm, sesame, rubber and fragrance；Fibre crops,
Such as cotton, flax and hemp；Sod grass（Including season type and shitivi type sod grass）.
The bactericidal composition of the present invention for preventing Cereal, veterinary antibiotics, fungi and thin on ornamental plant and grapevine
The purposes of bacterium.
The bactericidal composition of the present invention is especially suitable for prevention Chinese cabbage, tomato, cucumber, capsicum, potato, grape, balsam pear, lettuce
Lettuce, tobacco, turfgrass, rice, peanut, mandarin tree, wheat, barley, oat, fungi and bacterium on seeding corn and other crops plant.
The bactericidal composition of the present invention is considered being particularly suitable for control deuteromycetes Fusarium（Fusarium) disease,
Such as Fusarlum roseum (Fusariumroseum), Fusarium graminearum（Fusariumgraminearum), Fusarium oxysporum
（Fusariumoxysporum), fusarium moniliforme（ Fusariummoniliforme）；Ascomycetes Erysiphe
（Erysiphe) (including wheat powdery mildew（Erysiphegraminis), knotweed Powdery Mildew（Erysiphepolygoni))、
Grape powdery mildew（Uncinulanecatur), cucumber powdery mildew's pathogen（) and apple mildew Sphaerothecafuligena
Bacterium (Podosphaeraleucotricha) etc..
The bactericidal composition of the present invention can be used as foliage fungicide in crop protection, can also be used as fungicide for mixing
Plant and be used as soil fungicides.
The bactericidal composition of the present invention can be used for protecting plant, plant part, plant propagation material and the plant then grown
Sundries official.
Use of the bactericidal composition of the present invention for protecting plant, plant propagation material and the plant organ then grown
On the way.
The bactericidal composition of the present invention is used to handle seed the use invaded with the plant pathogenic fungi for protecting seed to carry
On the way.
The bactericidal composition of the present invention, can handle all plants and plant part." plant " refers to all plants and plant
Population, such as ideal and undesirable wild plant, cultivated plant and plant variety are (regardless of whether by plant variety or plant
Cultivate the protection of human rights profit).Cultivated plant and plant variety can be the plants obtained by Sterile culture and breeding method, this
A little methods can be aided with or be supplemented with one or more biological technique methods, such as use dihaploid, protoplast fusion, random
With orthomutation, molecule or genetic marker, or use bioengineering and genetic engineering method.Plant part refers to all of plant
Part and organ above and below the ground, such as bud, leaf, Hua Hegen, such as leaf, needle, stem, branch, flower, fructification, fruit and kind
Son and root, bulb and rhizome.It crop and nourishes and generates and case of propagation material, such as transplants, bulb, rhizome, running roots
Plant part is also belonged to seed.
A method of the bactericidal composition is acted on plant propagation material and then length by prevention plant pathogen
The plant organ gone out.
Term " plant propagation material " is interpreted as referring to all plant parts for having fertility, such as seed, can use
In breeding the latter and vegetable matter such as cuttage item or stem tuber（Such as potato）.Therefore, plant used herein
Part includes plant propagation material.It is mentioned that such as seed, root, fruit, stem tuber, bulb, rhizome and plant part.It waits for
The germination plant and effective plant inhibited after germinateing in soil or after emergence.Young plant can be before transplantation by being impregnated into
Row whole or Local treatment are protected.
Currently preferred plant propagation material is seed.The bactericidal composition of the present invention is also particularly suitable for processing seed.
Crop damage caused by most harmful fungoid is due to during storage or after sowing and in plant germination process
Or caused by the infringement of the seed after germination.Since the root and branch of growth period plant are especially sensitive and even if small damage
It can result in the death of plant.Another aspect of the present invention provides a kind of method of protection seed and germinating plants, and this method makes
After planting or without additionally applying crop protection agents after plant germination or at least significantly additionally using crop protection agents.It is another
Aspect, using the present invention bactericidal composition optimize used in reactive compound amount, with farthest provide seed and
The protection of germinating plants is against the invasion of plant pathogenic fungi, and plant itself will not be by used reactive compound
Damage.
Therefore, the present invention with the bactericidal composition of the present invention also more particularly to by handling seed to protect seed and hair
The method that bud plant invades from plant pathogenic fungi.The invention further relates to bactericidal compositions according to the present invention in processing kind
Son is to protect seed and germinating plants from the purposes of plant pathogenic fungi.
Harm budding after plant plant pathogenic fungi control mainly by using crop protection agents processing soil and
The aerial part of plant carries out.Healthy issuable influence in view of crop protection agents on environment and humans and animals,
It is therefore desirable to reduce the amount of application of reactive compound to the greatest extent.
Bactericidal composition according to the present invention is suitable for protection in agricultural, in greenhouse, in forestry or gardening-or vinegrowing
The seed of any plant variety of kind application.Particularly, the seed form used is cereal（Such as wheat, barley, rye, black
Wheat, millet, oat）, corn, cotton, soybean, rice, potato, sunflower, Kidney bean, coffee, beet, peanut, rape, olive
Olive, cocoa, sugarcane, tobacco, vegetables（Such as tomato, cucumber, onion and lettuce）, turfgrass and decoration use plant.Cereal and vegetable
The processing of the seed of vegetables is vital.
Active constituent 2-cyano-3-amino-3-phenylancryic acetate and tetraconazole in the bactericidal composition of the present invention is individually or with suitable preparation shape
Formula is applied to seed.It is preferably handled in the state of substantially stabilized so that processing will not cause any damage to seed.
In general, random time point that can be between picking and sowing carries out processing seed.Commonly used seed detaches simultaneously from plant
And it is isolated from cob, shell, stem, epidermis, hair or pulp.Therefore, it is possible to use for example, by picking, cleaning and dry to containing
Water is less than 15% seed.Alternatively, it is also possible to for example with water process after using drying, the seed then dried once more.
The medicament of the method for seed treatment, such as can there are, diluent liquid or solid-like or without dilution directly general
Seed is immersed in the method for making medicament be impregnated with seed in liquid condition solution, is blended in solid chemicals or liquid preparation and seed
Together, being coated processing makes the method for the surface of the seed attachment medicament, the methods of sprinkling near seed while plantation.
Plant part and the plant organ then grown are any of the plant generated by plant propagation material such as seed
Part.Plant part, plant organ and plant can also be benefited from by the way that bactericidal composition is applied to plant propagation material institute
The pathogenic damage of acquisition is protected.The plant organ grown behind certain plants part and certain places can also regard plant propagation as
Material, its own can be applied with bactericidal composition（Or processing）；To by processed plant part and processed plant
Plant, other plant parts and the other plant organs that organ generates can also be benefited from by applying bactericidal composition
With.
Bactericidal composition of the invention is applied to pathogenic or saprophytic in the required place prevention soil prevented or cultivation medium
Fungi and bacterium purposes.
A method of the bactericidal composition is acted on soil or cultivation medium by prevention plant pathogen.
The bactericidal composition of the present invention can also be used to prevent or control a variety of pathogenic or saprophytic in soil or cultivation medium
Fungi and bacterium.The example of the aquacultural fungal pathogen of soil-borne includes Alternaria（Alternaria spp.）, Ascochyta
(Ascochyta spp.), Botrytis cinerea（Botrytis cinerea, Cercospora（Cercospora spp., ergot
（Clavicepspurpurea）, standing grain cochliobolus（Cochliobolussativus）, Colletotrichum（colletotrichum
Spp., Epicoccum（Epicoccum spp., F.graminearum schw（Fusariumgraminearum）, beads Fusariumsp
（Fusariummoniliforme）, fusarium oxysporum（Fusariumoxysporum, fusarium moniliforme
（Fusariumproliferatum）, fusariun solani (Fusariumsolani), dimension glue chain spore
(Fusariumsubglitinans), Helminthosporium (Helminthosporiumspp) avenges rotten microtorr bacterium
(Microdochiumnivale), Penicillium (Pencilliumspp), Phoma (Phoma spp.), wheat nuclear cavity bacteria
(Pyrenophoragraminea), rice blast Pyricularia Sacc. (Pyriculariaoryzae), Rhizoctonia solani Kuhn
(Rhizoctoniasolani), Rhizoctonia cerealis (Rhizoctoniacerealis), Sclerotinia (Sclerotinia
Spp.), Septoria (Septoria spp.), silk axis smut (Sphacelothecareilliana), Tilletia
(Tilletia spp.), meat spore core coral bacterium (Typhula incarnate), hidden smut (Urocystisocculta) are black
Powder Pseudomonas (Ustilago spp.), Verticillium (Verticillium spp.), Phytophthora（Phytophthora), grass is rotten mould
It is withered to belong to（Pythium), Peronospora（Peronospora）, Pseudoperonospora (Pseudoperonospora）.
Under normal circumstances, soil germ can generate a large amount of thalline, as long as condition develops favorably and host pathogen growth
It is susceptible again, germ mass propagation and can infect host, and in the presence of susceptible host, these germs can enter
The lasting pathogenic phase, with the continuous cropping of crop mass propagation spread, but later nutrient be depleted or edaphic condition such as temperature,
When humidity etc. is unfavorable to germ, germ can enter rest period again.In the absence of susceptible host, soil-borne disease bacterium is in the soil
It can survive, in addition to soil germ has extensive host range, moreover it is possible to be deposited on the root surface of non-host or the broken branches and fallen leaves
It is living, it is undivided with saprophytic competitiveness with it.But different germs are discrepant, as sickle-like bacteria almost may be used in the soil
It is survived with indefinite duration.
Cultivation medium of the present invention is the supporter for referring to make crops take root, grow, such as：Soil, water etc.,
Specific raw material can use for example sand, float stone, vermiculite, diatomite, agar-agar, gelling material, polymer substance, asbestos,
Sawdust, bark etc..
The method that medicament is applied into soil, such as liquid preparation is diluted in water or is not diluted and is directly applied to plant
The methods of in the root of body or the rice seedling bed of seedling, granule is disseminated to the side in the root of plant or the rice seedling bed of seedling
Method has the method that pulvis, water dispersible granules etc. are sprayed in soil prior to seeding and are integrally mixed with soil, before sowing or plants
It will be sprayed in implantation hole, seed furrow after pulvis, water-dispersible grain dilution agent before kind plant, carrying out method of sowing etc..
The bactericidal composition of the present invention can also be used to prevent fruit vegetables storing period disease, and obtain unexpected collaboration
The effect of synergy.Such as the fruit rot caused by following pathogen：
Phytophthora（), such as phytophthora infestans (Phytophthorainfestans), phytophthora sojae kaufmann＆gerdemann Phytophthora
（Phytophthoramegasperma), foot rot of citrus bacterium（Phytophthoraparasitica)；
Peronosporaceae（Peronosporaceae) disease such as Plasmopara viticola（Plasmoparaviticola), Peronospora disease
Bacterium（Peronospora）；
Pythium（Pythium）Such as scraping and printing unit（Pythiumaphanidermatum).
According to the present invention, after harvest and the disease of storage period can be for example by caused by following fungi：Colletotrichum kind,
Such as banana thorn disk spore (Colletotrichum musae), Colletotrichum gloeosporiodes (Colletotrichum
Gloeosporioides), capsicum thorn disk spore (Colletotrichum coccodes)；Fusarium kind, such as half-naked reaping hook
Bacterium (Fusarium semitectum), fusarium moniliforme (Fusarium moniliforme), Fusarium solani (Fusarium
Solani), Fusarium oxysporum (Fusarium oxysporum)；Verticillium dahliae belongs to kind, such as cocoa verticillium sp
(Verticillium theobromae)；Nigrospora belongs to kind；Botrytis kind, such as the pathogen of Botrytis cinerea (Botrytis
cinerea)；Geotrichum, such as geotrichum candidum (Geotrichum candidum)；Phomopsis kind, Natal Phomopsis
(Phomopsis natalensis)；Diplodia kind, such as two spore of citrus color (Diplodia citri)；Alternaria kind, example
Such as Altemaria citri (Alternaria citri), mutually every Alternariaspp (Alternaria alternata)；Phytophthora kind, example
Such as phytophthora brown rot of citrus (Phytophthora citrophthora), strawberry phytophthora (Phytophthora fragariae), dislike
Phytophthora (Phytophthora cactorum), Phytophthora nicotianae (Phytophthora parasitica);Septoria
(Septoria spp.), such as Septoria depressa；Mucor (Mucor spp.), such as pyriform Mucor (Mucor
piriformis)；Chain sclerotinia sclerotiorum belong (Monilinia spp.), such as fruit life chain sclerotinia sclerotiorum (Monilinia
Fructigena), drupe chain sclerotinia sclerotiorum (Monilinia laxa)；Venturia (Venturia spp.), such as the black star of apple
Bacterium (Venturia inaequalis), Pear scab (Venturia pyrina)；Rhizopus (Rhizopus spp.), such as
Rhizopus stolonifer (Rhizopus stolonifer), Rhizopus oryzae (Rhizopus oryzae)；It is small from shell category (Glomerella
Spp.), such as enclose small from shell (Glomerella cingulata)；Sclerotinia (Sclerotinia spp.), such as fruit life
Sclerotinite (Sclerotinia fruiticola)；Long beak shell category (Ceratocystis spp.), such as unusual long beak shell
(Ceratocystis paradoxa)；Penicillium (Penicillium spp.), such as penicillium funiculosum (Penicillium
Funiculosum), penicillium expansum (Penicillium expansum), Penicillium digitatum (Penicillium digitatum),
Italian mould (Penicillium italicum)；The long spore category of disk (Gloeosporium spp.), such as the long spore of white disk
(Gloeosporium album), Gloeosporium perennans, the long spore (Gloeosporium of fruit life disk
fructigenum)、Gloeosporium singulata；Shell snake spore category (Phlyctaena spp.), such as Phlyctaena
vagabunda；Cylindrocarpon (Cylindrocarpon spp.), such as apple column spore (Cylindrocarpon mali)；It crawls handle
Mould category (Stemphyllium spp.), such as day lily stemphylium botryosum (Stemphyllium vesicarium)；Star check shell spore
Belong to (Phacydiopycnis spp.), such as Phacydiopycnis malirum；Thiclaviopsis (Thielaviopsis
Spp.), such as singular root string strain is mould (Thielaviopsis paradoxy)；Aspergillus (Aspergillus spp.) is such as black
Aspergillus (Aspergillus niger), Aspergillus carbonerius (Aspergillus carbonarius);Nectria (Nectria
), such as the red shell bacterium of dry cancer clump (Nectria galligena) spp.；Stockless Peziza (Pezicula spp.).
Can also when plant or plant part are grown using bactericidal composition according to the present invention to protect harvest after
Stock.
Processing method according to the present invention can also be used for the invasion for protecting stock from fungi and microorganism.According to this hair
It is bright, it is understood as referring to term " stock " to have originated from natural life cycle and it is desirable that the plant of long-term preservation or animality is come
The natural materials in source and its processed form.Stock, such as plant of plant origin or part thereof, as stem, leaf, stem tuber,
Seed, fruit or seed, can be with the state of fresh harvesting or with form processing such as (pre-) dry, wetting, crushing, grinding, pressure
System or baking are protected.Can also be timber, thick timber form such as construction timber, electric pole and fence；Or final product form, such as by
Furniture or article made of timber.The stock of animal origin is animal skin, leather, hair, hair etc..Composition according to the present invention
It can prevent the invasion such as burn into colour fading or mouldy of the fungi or bacterium of storage period.It is preferred that " stock " is understood as referring to plant
The natural materials in object source and its form processing, more preferable fruit and its form processing, as the operatic circle, drupe, soft fruit and
Citrus fruit and its form processing.
The present invention provides a kind of plant of control plant, plant part, plant propagation material and the plant organ then grown
The method of object disease fungus, this method include by the bactericidal composition of the present invention so that agronomy is effective and basic plant-less toxicity is applied
Dosage applied with seed treatment, foliage applying, stem, is impregnated with, instiled, poured into a mould, sprayed, sprayed, dusting, the methods of distribution or smoke
It is administered to plant, plant part, plant propagation material or plant and is growing or needs the soil grown wherein or cultivation matchmaker
In Jie.
The bactericidal composition of the present invention can be applied by different processing methods, these methods are for example：
Liquid comprising the bactericidal composition is sprayed onto to the aerial part of the plant；
Dusting mixes particle or powder in the soil, is sprayed in the surrounding plants, and the tree injection or smearing the case where
Under；
Cladding or film coated are carried out to the seed of plant.
When for postharvest fruit and vegetable anti-corrosive fresh-keeping, 200-2000 times of liquid is usually diluted with water, is leached after soaking fruit.
The present invention provides a kind of method of prevention plant pathogen, can be treatment, prevention or method of eradication.
The bactericidal composition of the present invention can be made into common dosage form, such as missible oil, wettable powder, suspending agent, liquid
The dosage forms such as agent, granule, seed coat agent use, amount of application, according to the mixing ratio, meteorological condition, medicament of active ingredient
Form, Dressing date, method of administration, using place, prevent and kill off object noxious livings, objective crop etc. it is different and variant.
A method of 2-cyano-3-amino-3-phenylancryic acetate and tetraconazole are administered simultaneously or apply respectively or phase by prevention plant pathogen
After application.
A method of prevention plant pathogen includes with agronomy by the bactericidal composition of the present invention effectively and substantially without plant
The amount of application of object toxicity applied with seed treatment, foliage applying, stem, is impregnated with, instiled, poured into a mould, sprayed, sprayed, dusting, distribution or
The methods of smoke is administered to plant pathogen and/or its environment or plant, plant part, plant propagation material and subsequent length
In the plant organ, soil or cultivation medium, material or the space that go out.
A method of the bactericidal composition is acted on plant or plant part by prevention plant pathogen.
A method of prevention plant pathogen, can plant by before infecting or after infecting by the Bactericidal composite
Object acts on plant pathogen and/or its environment or plant, plant part, plant propagation material and the plant then grown
In organ, soil or cultivation medium, material or space.
There may be super plus (" collaboration ") effects for processing according to the present invention.For example, the sterilization group used according to the present invention
It closes the rate of application of object and/or widens its field of activity and/or increase its activity, it is possible to obtain following effect：Better plant
Growth increases the tolerance of high temperature or low temperature, increases arid or the tolerance of water or soil salt content, and blooming performance carries
It is high, it is easier to harvest, the maturation of quickening, higher yield rate, the fruit of bigger, higher plant height, the color of leaf is more
It is green, it blooms earlier, the quality or nutritive value higher of the product of harvest, sugared concentration higher, the storage of the product of harvest in fruit
More preferably, these benefits have been more than the effect actually estimated for stability and/or processability.
The present invention processing method can be additionally used in handle propagating materials such as stem tuber or rhizome, and can be used for handle seed,
Seedling or transplanting (pricking out) seedling and plant or transplanting plant.The processing method can also be used for processing root.The present invention
Processing method can also be used for the aerial part of processing plant such as dry, stem or stalk, leaf, flower and fruit in relation to plant.
Generally for leaf portion processing：0.1-10000g/ha, preferably 10-1000g/ha, more preferable 50-500g/ha；For
For dipping or application of instiling, the dosage can also even reduce, especially when using inert base such as asbestos or perlite
Shi Shi；
For seed treatment：2-5000g/100kg seeds, preferably 3-1000g/100kg seeds；
For soil or processing used for ponds：0.1-10000g/ha, preferably 1-1000g/ha.
It is fresh-keeping for postharvest fruit and vegetable, 200-2000 times of liquid can be diluted, is leached after soaking fruit.
Above-mentioned dosage is only general exemplary dose, and those skilled in the art can be according to practical feelings when reality is applied
Condition and needs adjust rate of application especially in accordance with the seriousness of the property and germ of pending plant or crop.
The 2-cyano-3-amino-3-phenylancryic acetate of the present invention and tetraconazole combination/combined administration.Including separating, sequentially or simultaneously applying cyanogen alkene bacterium
Ester and tetraconazole.Preferably, the 2-cyano-3-amino-3-phenylancryic acetate and tetraconazole are combined as including the combination of 2-cyano-3-amino-3-phenylancryic acetate and tetraconazole
The form of object.
The present invention composition can be based on dosage form, i.e., each substance has mixed in composition, composition at
Point can also unit dose form provide, mixed in bucket or tank using preceding, be then diluted to required concentration.Wherein preferably with this hair
Based on the dosage form of bright offer.
As a further improvement on the present invention, bactericidal composition of the invention can be configured to the arbitrary agent agriculturally allowed
Type.
As a further improvement on the present invention, the dosage form of bactericidal composition of the invention is suspending agent, seed coat agent, wettable
Pulvis, microcapsule suspending agent, coated granule, squeezes out granule, missible oil, microemulsion, aqueous emulsion, effervescent tablet, surpasses water dispersible granules
Low capacity liquor, suspension emulsion.
In bactericidal composition of the present invention, including 2-cyano-3-amino-3-phenylancryic acetate and tetraconazole, filler and/or surface-active
Agent.
The content of bactericidal composition of the present invention, wherein 2-cyano-3-amino-3-phenylancryic acetate and tetraconazole accounts for the 5%- of bactericidal composition
90%。
The content of the bactericidal composition, wherein 2-cyano-3-amino-3-phenylancryic acetate and tetraconazole accounts for the 10%-80% of bactericidal composition.
The content of the bactericidal composition, wherein 2-cyano-3-amino-3-phenylancryic acetate and tetraconazole accounts for the 10%-60% of bactericidal composition.
According to the present invention, term " filler ", which refers to, can be combined with reactive compound or combines to make it easier for being administered to
Object（Such as plant, crop or careless class）Natural or synthetic organic or inorganic compound.Therefore, the filler is preferably
It is inert, it is acceptable at least to should be agricultural.The filler can be solid or liquid.
The nonactive medium that can be used in the present invention can be used as solid matchmaker either solid can also be liquid
What dielectric material used has for example：Phyteral powdery type（Such as soy meal, starch, grain dust, wood powder, bark powder, sawdust, walnut
The particle of shell powder, wheat bran, cellulose powder, coconut husk, corncob and tobacco stem extracts the residue etc. after plant essence）, paper
It opens, sawdust, crushes the synthesized polymer body, clay class of synthetic resin etc.（Such as kaolin, bentonite, acid china clay etc.）, talcum powder
Class.Silica（Such as diatomite, silica sand, mica, aqueous silicic acid, calcium silicates）, activated carbon, natural mineral matter class（Float stone, Lv Po
Thread stone and zeolite etc.）, fire diatomite, sand, plastics medium etc.（Such as polyethylene, polypropylene, polyvinylidene chloride etc.）, chlorination
Chemical fertilizer, the soil of the inorganic mineral powder of potassium, calcium carbonate, calcium phosphate etc., ammonium sulfate, ammonium phosphate, urea, ammonium chloride etc.
Fertilizer, these substances can be used alone or two or more is mixed.
It can be selected in llowing group of materials as liquid media materials'use, such as water, alcohol type（Such as first
Alcohol, ethyl alcohol, isopropanol, butanol, ethylene glycol etc.）, ketone（Such as acetone, methyl ethyl ketone, isobutyrone, cyclohexanone
Deng）, ethers（Such as ether, dioxanes, methylcellulose, tetrahydrofuran etc.）, aliphatic hydrocarbon class（Such as kerosene,
Mineral oil etc.）, aromatic hydrocarbons class（Such as benzene,toluene,xylene, solvent naphtha, alkylnaphthalene, chlorinated aromatic hydrocarbons, chloro fat
Fat hydrocarbon, chlorobenzene, etc.）, halogenated hydrocarbon class, amides, sulfone class, dimethyl sulfoxide (DMSO), mineral and vegetable oil, animal oil etc..
To make the emulsification of active ingredient compound, dispersion and/or wetting, it can use surfactant such as can be with
Enumerate fatty alcohol polyoxyethylene ether, polyoxyethylene alkylaryl ether, polyoxyethylene higher fatty acid esters, polyoxyethylene alcohol or phenol
Phosphate, the aliphatic ester of polyalcohol, alkane aromatic sulfonic acid, naphthalene sulfonic acid polymer, lignosulfonates, the branch shape of macromolecule comb shape are total
Polymers, butyl naphthalene sulfonate, alkylaryl sulfonates, sodium alkylsulfosuccinates, grease, fatty alcohol and ethylene oxide condensation
The polyacrylates such as object, alkyltaurate, protein hydrolysate.Suitable oligosaccharide object or polymer, such as based on independent
Vinyl monomer, acrylic acid, polyoxyethylene and/or polyoxypropylene or its with for example（It is polynary）Alcohol or（It is polynary）The combination of amine.
To make active ingredient compound dispersion stability, attachment and/or combination, such as xanthans, silicic acid can be used
Magnalium, gelatin, starch, methyl cellulose, polyvinyl alcohol, polyvinyl acetate and natural phospholipid（Such as cephalin and lecithin）With
And the adjuvants such as synthetic phospholipid, bentonite, sodium lignin sulfonate.
The wherein optional spent glycol of antifreezing agent, propylene glycol, glycerine, sorbierite.Deflocculant as suspension product
The adjuvant such as naphthalene sulfonic acid polymer, polymeric phosphate can be used.
Organic silicon defoamer can be used as antifoaming agent.
The colorant that can be used, such as inorganic pigment, such as iron oxide, titanium oxide and Prussian blue；And organic pigment/
Dyestuff：Alizarin dyes, azo dyes and metallized phthalocyanine dye；And trace element, such as molysite, manganese salt, boron salt, mantoquita, cobalt
Salt, molybdenum salt and zinc salt.
Optionally, also may include other annexing ingredients, for example, protecting colloid, adhesive, thickener, thixotropic agent, bleeding agent,
Stabilizer, screening agent.
The preparation of the present invention can be prepared by known way mixes the reactive compound with conventional additives.
The conventional additives such as conventional extender and solvent or diluent, emulsifier, dispersant, and/or adhesive or fixative,
Wetting agent, waterproofing agent, if it is desired, can also include drier and colorant, stabilizer, pigment, antifoaming agent, preservative, increasing
Thick dose, water and other processing aids.
These compositions include not only can be by suitable equipment such as spraying or dusting equipment immediately suitable for pending
Object, but also be included in be applied to before object and need the concentration commercial composition being diluted.
The 2-cyano-3-amino-3-phenylancryic acetate-containing and tetraconazole of the present invention can also be applied with other active ingredient combinations, such as expanding
Activity profile prevents from forming resistance.Other active constituents such as fungicide, attractant, insecticide, kills at bactericide
Mite agent, nematicide, growth regulator, herbicide, safener, fertilizer or semiochemical etc..
Reactive compound 2-cyano-3-amino-3-phenylancryic acetate and tetraconazole can be administered simultaneously, or apply respectively or sequential application, separate administration
When sequence on the result of prevention usually without influence.
The bactericidal composition of the present invention can be based on dosage form, i.e., each substance has mixed in composition, composition
Ingredient can also unit dose form provide, mixed in bucket or tank using preceding, be then diluted to required concentration.Wherein preferably with
Based on dosage form provided by the invention.
For the bactericidal composition of the present invention in the case where reducing reactive compound and applying total amount, having to harmful fungoid improves activity
（It is synergistic）.And the bactericidal composition of the present invention shows that the bacterium of tolerance also has excellent kill to existing fungicide
Bacterium effect.
A kind of bactericidal composition of the present invention, the composition is by combining 2-cyano-3-amino-3-phenylancryic acetate and tetraconazole so that obtains
Composition has gain effect in control effect, and has expanded fungicidal spectrum, plays the multi-purpose effect of a medicine, effectively slows down
Or germ is avoided to develop immunity to drugs.Astoundingly, the bactericidal activity of bactericidal composition of the invention is than each reactive compound
Active adduction it is considerably higher, there are unpredictable, necessary being synergistic effects, rather than just active supplement.
When reactive compound is present in specific weight ratio in the bactericidal composition of the present invention, synergistic effect is particularly evident.But
The weight ratio of reactive compound in bactericidal composition of the present invention can change in a certain range.
Example of formulations
+ 2% tetraconazole wettable powder of 1 20% 2-cyano-3-amino-3-phenylancryic acetate of embodiment
2-cyano-3-amino-3-phenylancryic acetate 20%
Tetraconazole 2%
Lauryl sodium sulfate 10%
Sodium lignin sulfonate 5%
Kaolin complements to 100%
By active constituent, various auxiliary agents and filler etc. by formula proportional components mix, after ultra-fine pulverizer disintegrating to get to
+ 2% tetraconazole wettable powder of 20% 2-cyano-3-amino-3-phenylancryic acetate.
+ 4% tetraconazole missible oil of 2 20% 2-cyano-3-amino-3-phenylancryic acetate of embodiment
2-cyano-3-amino-3-phenylancryic acetate 20%
Tetraconazole 4%
Ethoxylated castor oil 5%
Calcium dodecyl benzene sulfonate 3%
N-Methyl pyrrolidone complements to 100%
Mentioned component is proportionally prepared, uniform phase is uniformly mixing to obtain.
+ 5% tetraconazole water dispersible granules of 3 30% 2-cyano-3-amino-3-phenylancryic acetate of embodiment
2-cyano-3-amino-3-phenylancryic acetate 30%
Tetraconazole 5%
MODIFIED LIGNOSULPHONATE 5%
Lauryl sodium sulfate 5%
Urea 5%
Kaolin complements to 100%
2-cyano-3-amino-3-phenylancryic acetate active constituent, dispersant, wetting agent, disintegrant and filler are mixed according to the formula uniformly, by gas
Stream is ground into wettable powder；Tetraconazole is added to be uniformly mixed；It adds a certain amount of water mixing extruding and makes material.Through drying
+ 5% tetraconazole water dispersible granules of 30% 2-cyano-3-amino-3-phenylancryic acetate are obtained after screening.
+ 4% tetraconazole suspension emulsion of 4 24% 2-cyano-3-amino-3-phenylancryic acetate of embodiment
Oil phase：
2-cyano-3-amino-3-phenylancryic acetate 24%
Methyl oleate 4%
Ethoxylated castor oil 5%
Water phase：
Tetraconazole 50%
The sodium salt 1% of naphthalene sulfonic acids-formaldehyde condensation products of sulfonation
Water complements to 100%
Tetraconazole is dissolved in methyl oleate, ethoxylated castor oil is added and obtains oil phase；According to formula by 2-cyano-3-amino-3-phenylancryic acetate,
The aqueous suspension of 2-cyano-3-amino-3-phenylancryic acetate is obtained after sodium salt, the water of naphthalene sulfonic acids-formaldehyde condensation products of sulfonation is ground and/or high speed shear
Agent；The oil phase is added to the aqueous phase under stiring obtains suspension emulsion.
+ 2% tetraconazole coated granule of 5 16% 2-cyano-3-amino-3-phenylancryic acetate of embodiment
2-cyano-3-amino-3-phenylancryic acetate 16%
Tetraconazole 2%
Polyethylene glycol 3%
The silicic acid 1% of high degree of dispersion
Calcium carbonate complements to 100%
It in a mixer, will be on levigate active constituent even spread to the carrier soaked by polyethylene glycol.It can obtain by this method
Obtain dust-free coated granules agent.
+ 3% tetraconazole of 6 21% 2-cyano-3-amino-3-phenylancryic acetate of embodiment squeezes out granule
2-cyano-3-amino-3-phenylancryic acetate 21%
Tetraconazole 3%
Sodium lignin sulfonate 4%
Carboxymethyl cellulose 2%
Kaolin complements to 100%
Active component is mixed and ground with auxiliary agent, composition is soaked with water.The composition is squeezed out, is then done in the air stream
It is dry.
+ 2% tetraconazole suspension seed-coating agent of 7 30% 2-cyano-3-amino-3-phenylancryic acetate of embodiment
2-cyano-3-amino-3-phenylancryic acetate 30%
Tetraconazole 2%
Fatty alcohol polyoxyethylene ether sulfosuccinic acid monoesters disodium 10%
MODIFIED LIGNOSULPHONATE 5%
Xanthans 1%
Hydroxyethyl cellulose 1%
Glycerine 5%
PVP-K30 1%
Water complements to 100%
Seed coat agent is obtained after above-mentioned each component is mixed ground and/or high speed shear in proportion.
+ 5% tetraconazole microcapsule suspension-suspendinagent agent of 8 45% 2-cyano-3-amino-3-phenylancryic acetate of embodiment
Capsule core：
Tetraconazole 5%
Plurafac LF1312(from BASF) 3%
Emulsogen 3510 (from Clariant) 1%
Capsule wall：
Lupranat®M20S(BASF Elastogran) 8%
DETA (BASF SE) 2%
Water phase：
2-cyano-3-amino-3-phenylancryic acetate 45%
ATLOX ®4913 (from Croda) 5%
Synperonic PE/64 3%
Xanthans 1%
Antifoaming agent 1%
Urea 1%
1,2- propylene glycol 3%
Methylisothiazolinone 2%
Catalyst 0.1%
Water complements to 100%
The oil phase addition that Lupranat M20S, tetraconazole, Plurafac LF1312,3510 Emulsogen are formed is contained
In the aqueous solution of DETA, ATLOX 4913, emulsion is formed.Then it heats and keeps the temperature 50oCatalyst reaction 2 is added under C
Hour.The microcapsules of tetraconazole is obtained after cooling.
Synperonic PE/64 (from Croda), antifoaming agent, urea, 2-cyano-3-amino-3-phenylancryic acetate, water mix in proportion,
And through being sanded, it is prepared into aqueous suspension agent.
Microcapsules containing tetraconazole is added in the suspending agent of 2-cyano-3-amino-3-phenylancryic acetate, the microcapsule suspension-for obtaining the present invention is outstanding
Floating agent.
+ 4% tetraconazole suspending agent of 9 40% 2-cyano-3-amino-3-phenylancryic acetate of embodiment
2-cyano-3-amino-3-phenylancryic acetate 40%
Tetraconazole 4%
| Methyl naphthalene sulfonate formaldehyde condensate | 5% |
| Dioctyl succinate disulfonate acid | 5% |
| Xanthans | 0.3% |
| Glycerine | 5% |
| Antifoaming agent | 0.6% |
| Water | Complement to 100% |
The each components such as active component, dispersant, wetting agent and water are uniformly mixed according to the ratio of formula, it is ground and/or high
Speed shearing, control grain size is at 5 μm hereinafter, obtaining+4% tetraconazole suspending agent of 40% 2-cyano-3-amino-3-phenylancryic acetate.
+ 0.5% tetraconazole missible oil of 10 25% 2-cyano-3-amino-3-phenylancryic acetate of embodiment
2-cyano-3-amino-3-phenylancryic acetate 25%
Tetraconazole 0.5%
Ethoxylated castor oil 5%
Calcium dodecyl benzene sulfonate 3%
SOLVESSOTM100 complement to 100%
Above-mentioned each component is mixed, stirring is to obtaining transparent homogeneous phase.
+ 3% tetraconazole water dispersible granules of 11 45% 2-cyano-3-amino-3-phenylancryic acetate of embodiment
2-cyano-3-amino-3-phenylancryic acetate 45%
Tetraconazole 3%
MODIFIED LIGNOSULPHONATE 5%
Lauryl sodium sulfate 5%
Ammonium sulfate 2%
Kaolin complements to 100%
2-cyano-3-amino-3-phenylancryic acetate, tetraconazole active constituent, dispersant, wetting agent, disintegrant and filler are mixed according to the formula
It is even, by air-flow crushing at wettable powder；It adds a certain amount of water mixing extruding and makes material.45% is obtained after dry sieve
+ 3% tetraconazole water dispersible granules of 2-cyano-3-amino-3-phenylancryic acetate.
+ 2.5% tetraconazole aqueous emulsion of 12 12.5% 2-cyano-3-amino-3-phenylancryic acetate of embodiment
Oil phase：
| 2-cyano-3-amino-3-phenylancryic acetate | 12.5% |
| Tetraconazole | 2.5% |
| Methyl oleate | 40% |
| Polystyrene | 3.7% |
Water phase：
| Xanthans | 0.07% |
| The sodium salt of naphthalene sulfonic acids-formaldehyde condensation products of sulfonation | 1% |
| Fungicide | 0.2% |
| Water | Complement to 100% |
2-cyano-3-amino-3-phenylancryic acetate and tetraconazole are dissolved in methyl oleate, polystyrene is added and obtains oil phase；According to the group in formula
Divide to be uniformly mixed and obtains water phase；The oil phase is added to the aqueous phase under stiring obtains aqueous emulsion.
+ 3% tetraconazole microemulsion of 13 24% 2-cyano-3-amino-3-phenylancryic acetate of embodiment
2-cyano-3-amino-3-phenylancryic acetate 24%
Tetraconazole 3%
Ethoxylated castor oil 10%
Calcium dodecyl benzene sulfonate 10%
SOLVESSOTM100 50%
Water complements to 100%
Above-mentioned each component is mixed, stirring is to obtaining transparent homogeneous phase.
+ 10% tetraconazole of 14 90% 2-cyano-3-amino-3-phenylancryic acetate of embodiment
2-cyano-3-amino-3-phenylancryic acetate 90%
Tetraconazole 10%
2-cyano-3-amino-3-phenylancryic acetate, tetraconazole are proportionally uniformly mixed.
Proportioning is weight per distribution ratio in above example.
Biological test example
One, virulence is tested：
The toxicity index of each medicament and the co-toxicity coefficient of mixture are calculated according to Sun Yunpei's Method（CTC values）, when CTC≤80, then combine
Object shows antagonism, when 80<CTC<120, then composition show summation action, when CTC >=120, then composition shows
Go out synergistic effect.
Survey toxicity index (ATI)=(standard agent EC50/ reagent agent EC50) * 100
B in the percentage composition+B medicament toxicity index * mixtures of A in theoretical toxicity index (TTI)=A medicament toxicity index * mixtures
Percentage composition
Co-toxicity coefficient (CTC)=[mixture surveys toxicity index (ATI)/mixtures theoretical toxicity index (TTI) * 100
Phytopathogen and host plant used in greenhouse virulence test
| Host plant | Disease title | Genic organisms |
| Wheat | Wheat scab | Fusarium graminearum |
| Rice | Bakanae disease of rice | Fusarium moniliforme |
| Cucumber | Powdery mildew of cucumber | Cucumber powdery mildew fungus |
Experiment one：The toxicity test of Fusarium graminearum
Using inhibition mycelial growth rate method：
By 2-cyano-3-amino-3-phenylancryic acetate and tetraconazole respectively use acetone solution, then with 0.1% Tween-80 aqueous solution dilute be configured to be
The liquid of row concentration draws 6mL to the conical flask of sterilizing, 50 DEG C or so of potato Portugal is added respectively in superclean bench
Grape sugar agar medium（PDA）54mL pours into the plate of 4 diameter 9cm after shaking up, the toxic culture of 4 respective concentrations is made
Base；Toxic culture medium is made in the 2-cyano-3-amino-3-phenylancryic acetate of different ratio and tetraconazole series concentration compound solution with same method.
By 2 days Fusarium graminearums of culture, fungus block is broken into colony edge with the card punch of diameter 5mm, is moved to fungus block with transfer needle
The toxic PDA culture medium center being configured in advance, is subsequently placed in culture in 25 DEG C of incubators, and often processing is repeated 4 times.After 3 days, adopt
Each processing colony diameter cm is measured with crossing method slide calliper rule, correction is found out and inhibits percentage.Each bacterium colony right-angled intersection is surveyed
Two diameters represent bacterium colony size with its average.Then bacterium colony growth inhibition ratio is found out as the following formula：
Then concentration EC in inhibiting is calculated with least square method50, then according to Sun Yunpei's Method calculating co-toxicity coefficient（CTC）.
Table 1：To the virulence test result of Fusarium graminearum
As known from Table 1, the combination of 2-cyano-3-amino-3-phenylancryic acetate and tetraconazole is in proportioning 50:1-1:It is total to Fusarium graminearum when in 1 range
Malicious coefficient is all higher than 120, shows as synergistic effect.
Experiment two：The toxicity test of Fusarium moniliforme
Using inhibition mycelial growth rate method：
By 2-cyano-3-amino-3-phenylancryic acetate and tetraconazole respectively use acetone solution, then with 0.1% Tween-80 aqueous solution dilute be configured to be
The liquid of row concentration draws 6mL to the conical flask of sterilizing, 50 DEG C or so of potato Portugal is added respectively in superclean bench
Grape sugar agar medium（PDA）54mL pours into the plate of 4 diameter 9cm after shaking up, the toxic culture of 4 respective concentrations is made
Base；Toxic culture medium is made in the 2-cyano-3-amino-3-phenylancryic acetate of different ratio and tetraconazole series concentration compound solution with same method.
By 2 days Fusarium moniliformes of culture, fungus block is broken into colony edge with the card punch of diameter 5mm, is moved to fungus block with transfer needle
The toxic PDA culture medium center being configured in advance, is subsequently placed in culture in 25 DEG C of incubators, and often processing is repeated 4 times.After 3 days, adopt
Each processing colony diameter cm is measured with crossing method slide calliper rule, correction is found out and inhibits percentage.Each bacterium colony right-angled intersection is surveyed
Two diameters represent bacterium colony size with its average.Then bacterium colony growth inhibition ratio is found out as the following formula：
Then concentration EC in inhibiting is calculated with least square method50, then according to Sun Yunpei's Method calculating co-toxicity coefficient（CTC）.
Table 2：To the virulence test result of Fusarium moniliforme
As known from Table 2, the combination of 2-cyano-3-amino-3-phenylancryic acetate and tetraconazole is in proportioning 50:1-1:It is total to Fusarium moniliforme when in 1 range
Malicious coefficient is all higher than 120, shows as synergistic effect.
Experiment three：The Toxicity Determination of 2-cyano-3-amino-3-phenylancryic acetate and tetraconazole to powdery mildew of cucumber
Using inhibition mycelial growth rate method：
By 2-cyano-3-amino-3-phenylancryic acetate and tetraconazole respectively use acetone solution, then with 0.1% Tween-80 aqueous solution dilute be configured to be
The liquid of row concentration draws 6mL to the conical flask of sterilizing, 50 DEG C or so of potato Portugal is added respectively in superclean bench
Grape sugar agar medium（PDA）54mL pours into the plate of 4 diameter 9cm after shaking up, the toxic culture of 4 respective concentrations is made
Base；Toxic culture medium is made in the 2-cyano-3-amino-3-phenylancryic acetate of different ratio and tetraconazole series concentration compound solution with same method.
By 2 days cucumber powdery mildew fungus of culture, fungus block is broken into colony edge with the card punch of diameter 5mm, is moved to fungus block with transfer needle
The toxic PDA culture medium center being configured in advance, is subsequently placed in culture in 25 DEG C of incubators, and often processing is repeated 4 times.After 3 days, adopt
Each processing colony diameter cm is measured with crossing method slide calliper rule, correction is found out and inhibits percentage.Each bacterium colony right-angled intersection is surveyed
Two diameters represent bacterium colony size with its average.Then bacterium colony growth inhibition ratio is found out as the following formula：
Then concentration EC in inhibiting is calculated with least square method50, then according to Sun Yunpei's Method calculating co-toxicity coefficient（CTC）.
Table 3：To the virulence test result of cucumber powdery mildew fungus
As known from Table 3, the combination of 2-cyano-3-amino-3-phenylancryic acetate and tetraconazole is in proportioning 50:1-1:It is total to cucumber powdery mildew fungus when in 1 range
Malicious coefficient is all higher than 120, shows as synergistic effect.
Claims (16)
1. a kind of bactericidal composition, it is characterised in that：The bactericidal composition active constituent is by 2-cyano-3-amino-3-phenylancryic acetate and tetraconazole group
At the weight ratio of 2-cyano-3-amino-3-phenylancryic acetate and tetraconazole is 50:1-1:1, preferably 40:1-1:1, more preferable 30:1-1:1, more preferable 25:
1-1:1, further preferably 20:1-1:1, more preferable 15:1-5:1, more preferable 15:1-8:1.
2. bactericidal composition according to claim 1, it is characterised in that：The 2-cyano-3-amino-3-phenylancryic acetate and tetraconazole quality sum
Account for the 5%-90% of the Bactericidal composite amount of substance, preferably 10%-80%, more preferable 20%-70%.
3. bactericidal composition according to claim 1, it is characterised in that：The bactericidal composition, dosage form be suspending agent,
Seed coat agent, wettable powder, water dispersible granules, microcapsule suspending agent, coated granule, squeezes out granule, is missible oil, micro- suspension emulsion
Emulsion, aqueous emulsion, effervescent tablet, ultra low volume liquids, dry suspension.
4. bactericidal composition according to claim 1, it is characterised in that：Also include filler and/or surfactant.
5. a kind of method of prevention plant pathogen, it is characterised in that：Bactericidal composition described in claim 1 is acted on into plant
Object pathogenic bacteria and/or its environment or plant, plant part, plant propagation material and the plant organ then grown, soil or
It cultivates in medium, material or space.
6. a kind of method of prevention plant pathogen, it is characterised in that：By 2-cyano-3-amino-3-phenylancryic acetate described in claim 1 and tetraconazole
It is administered simultaneously or applies respectively or sequential application.
7. a kind of method of prevention plant pathogen, it is characterised in that：It is wanted before infecting or by right after infecting in plant
The bactericidal composition described in 1 is asked to act on plant pathogen and/or its environment or plant, plant part, plant propagation material
In the plant organ, soil or cultivation medium, material or the space that then grow.
8. a kind of method of prevention plant pathogen, it is characterised in that：Including by bactericidal composition described in claim 1 with agriculture
Learn the amount of application of effective and basic plant-less toxicity applied, be impregnated with seed treatment, foliage applying, stem, instiled, poured into a mould, sprayed,
The methods of spraying, dusting, distribution or smoke are applied to plant pathogen and/or its environment or plant, plant part, plant
In propagating materials and the plant organ then grown, soil or cultivation medium, material or space.
9. bactericidal composition described in claim 1 is true on Cereal, veterinary antibiotics, ornamental plant and grapevine for preventing
The purposes of bacterium and bacterium.
10. bactericidal composition described in claim 1 is for controlling Cereal, veterinary antibiotics, sickle on ornamental plant and grapevine
Knife Pseudomonas（Fusarium) disease and Erysiphe（Erysiphe) disease.
11. bactericidal composition described in claim 1 is for controlling Cereal, veterinary antibiotics, powder on ornamental plant and grapevine
Red sickle-like bacteria (Fusariumroseum), Fusarium graminearum（Fusariumgraminearum), Fusarium oxysporum
（Fusariumoxysporum), fusarium moniliforme（ Fusariummoniliforme）, wheat powdery mildew
（Erysiphegraminis), erysiphe polygoni（Erysiphepolygoni), grape powdery mildew（Uncinulanecator)、
Cucumber powdery mildew's pathogen（) and the use of apple mildew bacterium (Podosphaeraleucotricha) Sphaerothecafuligena
On the way.
12. bactericidal composition described in claim 1 is for protecting plant, plant propagation material and the plant organ then grown
Purposes.
13. bactericidal composition described in claim 1 is applied to the required place prevention soil prevented or causes a disease in cultivation medium
Or the purposes of saprophytic fungi and bacterium.
14. bactericidal composition described in claim 1 is used to handle seed the phytopathogen invasion to protect seed carrying
Purposes.
15. bactericidal composition described in claim 1 is used to protect the purposes of the fruits and vegetables after harvest.
16. bactericidal composition described in claim 1 is for protecting stock in storage period from fungi or the use of bacterial invasion
On the way.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111742803A (en) * | 2020-06-19 | 2020-10-09 | 唐山市农业科学研究院 | Efficient cultivation method based on ginger micro-sprinkling irrigation water and fertilizer integration |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101595890A (en) * | 2009-05-07 | 2009-12-09 | 深圳诺普信农化股份有限公司 | A kind of 2-cyano-3-amino-3-phenylancryic acetate and triazole type composition and application thereof |
| CN106508914A (en) * | 2016-10-31 | 2017-03-22 | 青岛瀚生生物科技股份有限公司 | Sterilizing composition |
-
2017
- 2017-03-02 CN CN201710118772.9A patent/CN108522516A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101595890A (en) * | 2009-05-07 | 2009-12-09 | 深圳诺普信农化股份有限公司 | A kind of 2-cyano-3-amino-3-phenylancryic acetate and triazole type composition and application thereof |
| CN106508914A (en) * | 2016-10-31 | 2017-03-22 | 青岛瀚生生物科技股份有限公司 | Sterilizing composition |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111742803A (en) * | 2020-06-19 | 2020-10-09 | 唐山市农业科学研究院 | Efficient cultivation method based on ginger micro-sprinkling irrigation water and fertilizer integration |
| CN111742803B (en) * | 2020-06-19 | 2021-08-17 | 唐山市农业科学研究院 | Efficient cultivation method based on ginger micro-sprinkling irrigation water and fertilizer integration |
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