CN108187032A - 虫草胶原蛋白肽片 - Google Patents
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Abstract
本发明公开了虫草胶原蛋白肽片，虫草胶原蛋白肽片，包括以下重量份数的成分：虫草多糖复合物35‑55份、鹿肉粉6‑10份、覆盆子1‑2份，枸杞8‑10份，酸枣仁5‑7份，海洋鱼低聚肽4‑8份。本发明通过虫草多糖复合物的特殊性，实现鹿肉粉、覆盆子，枸杞，酸枣仁，海洋鱼低聚肽功效的进一步增强，同时通过上述多种成分合理配伍协同增效，有效达到滋阴补肾，改善睡眠，美容养颜。而且本发明采用药食同源的原料，采用安全级别最高，即可以不限制用量的食品类原料进行合理配伍，兼具功效和安全性，无副作用，且无剂量限值。
Description
技术领域
本发明涉及一种虫草胶原蛋白肽片。
背景技术
虫草中所含有的虫草多糖是虫草体内含量最丰富、最重要的生物活性物质之一，具有广泛药理作用。近年来资源日益衰竭，人们尝试培养虫草菌丝体、子实体作天然虫草的替代，已经获得不同程度的认可。国家一类新药虫草菌粉，系采用从天然虫草中分离出虫草菌种，人工培养液体发酵和固体培养制成。
蛹虫草为子囊菌门，肉座目，虫草菌科、虫草属的模式种，又名北冬虫夏草、北虫草等。蛹虫草目前已实现人工栽培。虫草素、虫草酸和虫草多糖复合物是冬虫夏草菌特有的物质，是冬虫夏草特殊功效的主要指标。而恰恰是这些指标，在人工环境优裕条件下生长的北冬虫夏草含量可以比天然条件下生长得更高。人工培养的北冬虫夏草的蛋白质、氨基酸、维生素等含量均达到或超过天然冬虫夏草的水平。虽然人工培养的北冬虫夏草中的个别营养成分略低于天然冬虫夏草水平，但这些营养成分是可以通过研究加以提高的。
随着虫草传统功效不断地发掘，特别是虫草成份对应的药理研究和临床疗效果都得到了消费者的肯定，以虫草为原料的药品和保食品、保健品逐步开发并进入市场。根据国家食品药品监督管理局数据查询的结果，国产虫草保健食品大部分是原草或培育虫草直接销售，或是进行打粉、压片等粗加工销售，以单纯虫草制成的保健食品供应有两项弊端。
一是考虑到虫草价格昂贵，单品达到同样效果日服用剂量较大，产品价格较高，而令普通消费者难以承受；
二是没有基于中医基础理论，通过中药君、臣配伍发挥其最大效果，而使保健效能更为突出。
目前市场上多以简单的虫草鲜草、干草原材料进行销售，虫草深加工产品种类比较单一且数量少，虫草成份市场大部分走向高端医药产品为主，严重制约了虫草组合的附加价值和经济效益。且现有虫草饮品配方生产工艺不够合理，使得活性成分被破坏，营养物质损失过多，营养不均衡、保健作用不明显；另外在产品生产过程中添加过多辅料，如蔗糖、防腐剂、人工色素等，有损消费者身体健康，无法满足消费者滋补养生的需求。
发明内容
本发明针对上述问题，提出了一种虫草多糖复合物，鹿肉粉、覆盆子，枸杞，酸枣仁，海洋鱼低聚肽的配伍，以解决了现有技术虫草产品的缺陷，达到协同增效，滋阴补肾，改善睡眠，美容养颜的目的。
本发明采取的技术方案如下：
本发明提供一种虫草胶原蛋白肽片，包括以下重量份数的成分：
虫草多糖复合物35-55份、鹿肉粉6-10份、覆盆子1-2份，枸杞8-10份，酸枣仁5-7份，海洋鱼低聚肽4-8份，
所述虫草多糖复合物包括虫草多糖和虫草基础成分，其中所述虫草基础成分选自下列之一：
虫草粉或虫草发酵菌丝体的提取物或浓缩物；
其中虫草为虫草属真菌寄生并能产生子实体的菌物结合体，包括冬虫夏草，蛹虫草及虫草属的其他种。
进一步，所述虫草为蛹虫草。
进一步，所述虫草多糖利用蛹虫草提取的多糖或者液体发酵培养蛹虫草菌丝体，然后从发酵液中提取虫草多糖进行纯化。
进一步，所述虫草多糖复合物中虫草多糖的重量份数为20％-35％。
进一步，所述虫草胶原蛋白肽片由以下重量份数的成分组成：虫草多糖复合物45份、鹿肉粉8份、覆盆子1份，枸杞9份，酸枣仁6份，海洋鱼低聚肽5份。
进一步，所述虫草多糖复合物中虫草多糖的重量份数为30％。
进一步，所述虫草胶原蛋白肽片制成片剂。
本发明还提供一种上述虫草胶原蛋白肽片在制备补肾生精的药物/食品/保健品中的应用。
与现有技术相比，本发明的有益效果是：
本发明在虫草有效成分基础配方中加上高含量多糖的复合配方的重复价值是对人体的疾病预防、治疗、延年益寿更精准、更高效、更合理和均衡。在实践中纯粹的多糖高含量也远未达到上述预期目标，而发明人经过多年研究和实践发现，达到最高阀值的虫草基础有效成份(或者浓缩基础有效成份)配上高含量多糖时对人类疾病的预防、治疗、延年益寿达到最佳效果。而且虫草多糖复合物可以增强人体对其他物质的吸收效果，从而提升其他成分的功效。
枸杞补肾益精，养肝明目，补血安神，生津止渴，润肺止咳。于调理肝肾阴亏，腰膝酸软，头晕，目眩，目昏多泪，虚劳咳嗽，消渴，遗精。
鹿肉粉对失眠盗汗，内脏积水引起心跳、心慌等症有显效，治肺痿吐血。治阳痿、早泄、腰痛、形寒肢冷，妇人性冷淡、头晕、目眩、精神不振等症。
覆盆子性温，味甘、酸。其功能主治益肾，固精，缩尿。用于肾虚遗尿、小便频数、阳痿早泄、遗精滑精。覆盆子似有雌激素样作用。覆盆子中所含的黄酮类物质，除了具有抗菌消炎、降低血压及抗过敏等作用外，它们在护肤养颜方面也身手不凡。这类物质可以改善皮肤血液循环，增强皮肤毛细血管弹性，促进皮肤细胞再生，从而发挥美容养颜的功用。
酸枣仁作为中草药使用已有1700年的历史，《本草纲目》记载；“酸枣味酸，性平，主祛邪气，安中养身，平胃气，通九窍，助十二经，补中气，增津液”，现代研究含有多种脂肪油和蛋白质并有两种甾醇，还有两种三萜化合物、皂甙、多种维生素等，所含成份具有镇静、安神、催眠作用。
胶原蛋白是由3条肽链拧成螺旋纤维状蛋白质也是人体内含量最丰富的蛋白质广泛分布于结缔组织、皮肤、骨骼、内脏细胞间质及肌腔、韧带、巩膜等部位。胶原蛋白是皮肤的主要组成部分占皮肤真皮层80％的比重，它在皮肤中构成了一张细密的弹力网，牢固锁住水分支撑着皮肤。小分子胶原蛋白肽相对于大分子胶原蛋白分子量小，更易吸收，且具有独特功效。海洋鱼低聚肽是以无污染或污染相对较小的深海鱼的皮、骨为原料，精制加工而成，是小分子易吸收的胶原蛋白肽，可以保护皮肤、眼睛、血管，滋润头发。
本发明通过虫草多糖复合物的特殊性，实现鹿肉粉、覆盆子，枸杞，酸枣仁，海洋鱼低聚肽功效的进一步增强，同时通过上述多种成分合理配伍协同增效，有效达到滋阴补肾，改善睡眠，美容养颜。而且本发明采用药食同源的原料，采用安全级别最高，即可以不限制用量的食品类原料进行合理配伍，兼具功效和安全性，无副作用，且无剂量限值。
具体实施方式：
下面结合具体实施例，对本发明做详细描述。
实施例1
虫草胶原蛋白肽片
取虫草菌丝体，液态发酵法进行培养，培养5天后，提取培养物中的虫草多糖，提取方法采用现有技术即可，得到虫草粗多糖。然后对虫草粗多糖进行提纯，获得纯度大于90％的虫草多糖。
另取虫草菌丝体培养物进行浓缩，浓缩10倍后得到虫草培养液浓缩物，按重量百分数，30％的虫草多糖，70％的虫草培养液浓缩物配置虫草多糖复合物。
按以下重量份数配置虫草胶原蛋白肽片：
虫草多糖复合物35份、鹿肉粉6份、覆盆子1份，枸杞8份，酸枣仁5份，海洋鱼低聚肽4份，得到虫草胶原蛋白肽片。
实施例6
虫草胶原蛋白肽片
取蛹虫草菌丝体，液态发酵法进行培养，培养8天后，提取培养物中的虫草多糖，提取方法采用现有技术即可。本实施例选择用水提法提取，得到虫草粗多糖。然后对虫草粗多糖进行提纯，获得纯度大于95％的虫草多糖。
另取蛹虫草菌丝体培养物进行浓缩，浓缩10倍后得到虫草培养液浓缩物，按重量百分数，35％的虫草多糖，65％的虫草培养液浓缩物配置虫草多糖复合物。
按以下重量份数配置虫草胶原蛋白肽片：
虫草多糖复合物55份、鹿肉粉10份、覆盆子2份，枸杞10份，酸枣仁7份，海洋鱼低聚肽6份，得到虫草胶原蛋白肽片，得到虫草胶原蛋白肽片。
实施例7
虫草胶原蛋白肽片
取蛹虫草菌丝体，液态发酵法进行培养，培养10天后，提取培养物中的虫草多糖，提取方法采用现有技术即可。本实施例选择用水提法提取，得到虫草粗多糖。然后对虫草粗多糖进行提纯，获得纯度大于99％的虫草多糖复。
另取蛹虫草菌丝体培养物进行浓缩，浓缩10倍后得到虫草培养液浓缩物，按重量百分数，30％的虫草多糖，70％的虫草培养液浓缩物配置虫草多糖复合物。
按以下重量份数配置虫草胶原蛋白肽片：
虫草多糖复合物45份、鹿肉粉8份、覆盆子1份，枸杞9份，酸枣仁6份，海洋鱼低聚肽5份，配制后压片制成片剂。
以上所述仅为本发明的优选实施例，并非因此即限制本发明的专利保护范围，凡是运用本发明说明书内容所作的等效变换，直接或间接运用在其他相关的技术领域，均同理包括在本发明的保护范围内。
Claims (7)
1.虫草胶原蛋白肽片，其特征在于，所述虫草胶原蛋白肽片包括以下重量份数的成分：
虫草多糖复合物35-55份、鹿肉粉6-10份、覆盆子1-2份，枸杞8-10份，酸枣仁5-7份，海洋鱼低聚肽4-8份，
所述虫草多糖复合物包括虫草多糖和虫草基础成分，其中所述虫草基础成分选自下列之一：
虫草粉或虫草发酵菌丝体的提取物或浓缩物；
其中虫草为虫草属真菌寄生并能产生子实体的菌物结合体，包括冬虫夏草，蛹虫草及虫草属的其他种。
2.如权利要求1所述的虫草胶原蛋白肽片，其特征在于，所述虫草为蛹虫草。
3.如权利要求2所述的虫草胶原蛋白肽片，其特征在于，所述虫草多糖利用蛹虫草提取的多糖或者液体发酵培养蛹虫草菌丝体，然后从发酵液中提取虫草多糖进行纯化。
4.如权利要求2所述的虫草胶原蛋白肽片，其特征在于，所述虫草多糖复合物中虫草多糖的重量份数为20％-35％。
5.如权利要求1所述的虫草胶原蛋白肽片，其特征在于，所述虫草胶原蛋白肽片由以下重量份数的成分组成：虫草多糖复合物45份、鹿肉粉8份、覆盆子1份，枸杞9份，酸枣仁6份，海洋鱼低聚肽5份。
6.如权利要求5所述的虫草胶原蛋白肽片，其特征在于，所述虫草多糖复合物中虫草多糖的重量份数为30％。
7.如权利要求1-6任意一项所述的虫草胶原蛋白肽片，其特征在于，所述虫草胶原蛋白肽片制成片剂。
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| CN109090618A (zh) * | 2018-08-06 | 2018-12-28 | 佗鹊堂国投生物科技股份有限公司 | 虫草胶原蛋白肽口服液 |
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