CN108186993A - A kind of antitumor drug and preparation method thereof - Google Patents

A kind of antitumor drug and preparation method thereof Download PDF

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Publication number
CN108186993A
CN108186993A CN201810253859.1A CN201810253859A CN108186993A CN 108186993 A CN108186993 A CN 108186993A CN 201810253859 A CN201810253859 A CN 201810253859A CN 108186993 A CN108186993 A CN 108186993A
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antitumor drug
weight
pharmaceutical chemicals
bulk pharmaceutical
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程鹏
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First Affiliated Hospital of Nanyang Medical College
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First Affiliated Hospital of Nanyang Medical College
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    • A—HUMAN NECESSITIES
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/748—Oldenlandia or Hedyotis
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    • A61K36/06—Fungi, e.g. yeasts
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    • A61K36/074—Ganoderma
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/185—Magnoliopsida (dicotyledons)
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    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
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Abstract

The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of antitumor drug and preparation method thereof.The antitumor drug is made of the bulk pharmaceutical chemicals of following parts by weight：12 26 parts of 10 15 parts of oldenlandia diffusa, 20 30 parts of Asian puccoon, 18 28 parts of the root bark of shaggy-fruited dittany, 6 13 parts of curcuma zedoary, 8 15 parts of trigone, 15 20 parts of the radix paeoniae rubrathe, 10 20 parts of Rhizoma Atractylodis Macrocephalae, 15 25 parts of dried orange peel, 10 20 parts of hawthorn, 20 30 parts of ganoderma lucidum and lily.Antitumor drug of the present invention is mended without stagnant, is rushed down without void, temperature of trembling with fear is suitable, the foster taste of temperature, heat-clearing dissipating bind, promoting blood circulation and stopping pain, and tumor killing effect is good.

Description

A kind of antitumor drug and preparation method thereof
Technical field
The invention belongs to technical field of traditional Chinese medicines, and in particular to a kind of antitumor drug and preparation method thereof.
Background technology
Tumour refers to body under the effect of the various tumorigenesis factors, and the neoformation that local organization hyperplasia is formed, is prestige Coerce the number one killer of modern's health.The therapy of the inoperable tumour of western medical treatment mainly uses chemotherapy and radiation, but Above two method toxicity is apparent, and patient feels very painful during treating.Reaction and late tumor medication are Chinese traditional treatments The characteristic of tumour.The traditional Chinese medical science thinks that cancer pain is mainly to be stored in cult poison, stagnation of the circulation of vital energy blood addiction, not general rule pain.Relaxing tumor pain its Clinical manifestation can be divided into Sheng type in cult poison, blood addiction type and Qi-stagnation type.Sheng type is often shown as local scorching hot in cult poison, and pain is fixed not It moves, that touches exacerbates；Blood addiction type often shows as the fixed needle pricked pain in part, dark tongue quality, and tongue has addiction spot；Qi-stagnation type is often shown as Migratory pain attacks and alters distending pain.
Notification number is that the Chinese patent of CN102988781B discloses a kind of Traditional Chinese medicine liniment for inhibiting cancerous swelling and its analgesic, packet Active ingredient contained by the raw material of following weight ratio is included to form：Safflower 8-12, safflower 15-25, Radix Notoginseng 35-45, Rhizoma Gastrodiae 12-18, Cow-bezoar 8-12, root of Dahurain angelica 8-12, rhodiola root 12-22, borneol 4-8, camphor 6-10, mediocre perfume 1-2, Radix Isatidis 8-12.The liniment is The ingredients of skin medication, application method are to smear affected area or the skin close to affected area, and through lesion, tool are imported through capillary There is the characteristics of utilization rate of active components is high, effect is rapid.But each raw material smell of the patent is pungent, and camphor toxicity is big, it is long Phase uses the discomfort or allergic reaction that can cause skin.
The Chinese patent that notification number is CN102078517B discloses a kind of Chinese medicine for treating tumour, the treatment tumour Chinese medicine is mixed by the active compound of following parts by weight, and oldenlandia diffusa 20, melon wither 30, root of subprostrate sophora 6, Sculellaria barbata 30, Radix Salviae Miltiorrhizae 30, red Chinese herbaceous peony 30, Radix Angelicae Sinensis 30, stone solution 30, Huang are slightd 30, cornu bubali 20, Radix Aucklandiae 10, honeysuckle 30, Fructus Forsythiae 30, Cortex Phellodendri 30, American Ginseng 10, are worn Naze 5, the medicine can inhibit the growth of tumour, for tumor patient fever, lump increase, cytometaplasia, the scorching hot, pain in part, It becomes thin, is thirsty, swallowing dry, constipation, red tongue with yellowish fur, lacking tongue or without tongue, the symptoms such as arteries and veins unrest or arteries and veins are thin tool improves significantly.But It is that the patent qi-replenishing and blood-enriching medicine easily grows greasy stagnant gas, lacks spleen benefiting and stimulating the appetite medicine, influences the absorption of active ingredient, and cold and cool medicine Type is on the high side, is not suitable for weakness of the spleen and the stomach person and takes.
Invention content
To overcome drawbacks described above, the purpose of the present invention is to provide a kind of antitumor drugs and preparation method thereof.
To achieve the above object, the present invention adopts the following technical scheme that：
A kind of antitumor drug is made of the bulk pharmaceutical chemicals of following parts by weight：
10-15 parts of oldenlandia diffusa, 20-30 parts of Asian puccoon, 18-28 parts of the root bark of shaggy-fruited dittany, 6-13 parts of curcuma zedoary, 8-15 parts of trigone, radix paeoniae rubrathe 15- 12-26 parts of 20 parts, 10-20 parts of Rhizoma Atractylodis Macrocephalae, 15-25 parts of dried orange peel, 10-20 parts of hawthorn, 20-30 parts of ganoderma lucidum and lily.
Preferably, the antitumor drug is made of the bulk pharmaceutical chemicals of following parts by weight：
12-14 parts of oldenlandia diffusa, 24-27 parts of Asian puccoon, 19.5-25 parts of the root bark of shaggy-fruited dittany, 9-12 parts of curcuma zedoary, 10-12 parts of trigone, the radix paeoniae rubrathe 18-23 parts of 16-18.5 parts, 12-16 parts of Rhizoma Atractylodis Macrocephalae, 18-23 parts of dried orange peel, 13-17 parts of hawthorn, 23.5-27 parts of ganoderma lucidum and lily.
Preferably, the antitumor drug is made of the bulk pharmaceutical chemicals of following parts by weight：
It is 13 parts of oldenlandia diffusa, 25 parts of Asian puccoon, 22 parts of the root bark of shaggy-fruited dittany, 10 parts of curcuma zedoary, 10 parts of trigone, 17 parts of the radix paeoniae rubrathe, 14 parts of Rhizoma Atractylodis Macrocephalae, old 20 parts of 20 parts of skin, 14 parts of hawthorn, 25 parts of ganoderma lucidum and lily.
A kind of preparation method of above-mentioned antitumor drug, includes the following steps：
（1）Various bulk pharmaceutical chemicals are mixed, are ground into 100-150 μm of powder；
（2）By step（1）Powder measures ethyl alcohol using 5-10 times and impregnates 1-3h, and 10-30min is extracted in ultrasonic extraction tank, is extracted 2-3 times, merge extracting solution；
（3）By step（2）Extracting solution filtering, concentration, obtain the medicinal extract that relative density is 1.1-1.3, and addition accounts for medicinal extract weight 10- 20% auxiliary material is uniformly mixed, and is dried in vacuo, and is crushed, and crosses 20-40 mesh sieve series grains, dress capsule to obtain the final product.
Preferably, step（2）The volume fraction of ethanol is 50%-90%.
Preferably, step（2）The Extracting temperature is 52-57 DEG C, ultrasonic power 500-1000W.
Preferably, step（3）The auxiliary material is dextrin, lactose or soluble starch.
The instructions of taking of antitumor drug of the present invention：3 times a day, one time 3, every 0.3-0.5g.
The pharmacological action of each bulk pharmaceutical chemicals of the present invention：
Oldenlandia diffusa：It is sweet, light, it is cool, enter stomach, large intestine, small intestinl channel, clearing heat and detoxicating, inducing diuresis to remove edema, promoting blood circulation and stopping pain, for acute appendicitis, Sore furuncle poison, jaundice with damp-heat pathogen, difficult urination.Modern study finds that oldenlandia diffusa has the function of to treat cancerous swelling.
Asian puccoon：It is sweet, salty, it trembles with fear, converge to heart and liver channels, clearing heat and cooling blood, promoting blood circulation and detoxication, promoting eruption ecchymose removing, for blood-heat and toxin exuberance, macula Purple black, measles without adequate eruption, sore, eczema, scald.Modern study finds that Asian puccoon has antitumor action.
The root bark of shaggy-fruited dittany：Hardship is trembled with fear, returns spleen, stomach, bladder warp, heat-clearing and damp-drying drug, and wind-dispelling removing toxic substances, for damp and hot sore, yellow water is dripping, Shi Shen, rubella, mange sore leprosy, beriberoid pyretic arthralgia, jaundice.Modern study finds that the root bark of shaggy-fruited dittany has antitumaous effect.
Curcuma zedoary：It is pungent, bitter, temperature, Return liver, the spleen channel, promoting the circulation of qi blood-breaking, Xiao Ji Zhi Tong, Yong Yu abdominal mass and lump, tired Amenorrhea, the obstruction of qi in the chest heart Bitterly, dyspepsia distending pain.Modern study finds that curcuma zedoary has antitumor action.
Trigone：It is pungent, bitter, it puts down, Return liver, the spleen channel, blood-breaking, Xiao Ji Zhi Tong, Yong Yu abdominal mass and lump, dysmenorrhoea, blood stasis closed, Chest impediment and cardialgia, dyspepsia distending pain.
The radix paeoniae rubrathe：Hardship is slightly cold, return liver warp, clearing heat and cooling blood, removing blood stasis and analgesics, for thermal man's ying blood, febrile virulent maculae, and hematemesis and epistaxis, Red eye, swell pain, liver-depressed hypochondrium pain, closed dysmenorrhea , Disorder lump in the abdomen is suffered from abdominal pain, injury from falling down, carbuncle swells sore.
Rhizoma Atractylodis Macrocephalae：Bitter, sweet, warm, returns spleen, stomach, strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, tocolysis, for spleen Virtual deficiency of food, abdominal distension Diarrhea, phlegm retention anti-dazzle nervous, oedema, spontaneous perspiration, fetal irritability.
Dried orange peel：Bitter, pungent, warm-natured, return lung, the spleen channel, regulating qi-flowing for strengthening spleen is eliminating dampness and eliminating phlegm, and for abdominal fullness and distention, deficiency of food is vomited and diarrhoea, Coughing with a lot of sputum.
Hawthorn：Sour, sweet, tepor, returns spleen, stomach, Liver Channel, food digesting stomach fortifying, scattered stasis changes turbid lipid-loweringing, for meat stagnation, Gastral cavilty turgor, diarrhea dysentery abdominal pain, blood stasis closed, postpartum stasis, confidant sting, chest impediment and cardialgia, hernia pain, hyperlipidemia.
Ganoderma lucidum：Sweet and neutral, the thoughts of returning home, lung, liver and kidney channel, invigorating qi for tranquilization is relieving cough and asthma, and for dizziness egersis, palpitation is empty Phthisical cough is breathed heavily.Modern study finds, the ganoderma lucidum polysaccharide contained in ganoderma lucidum can pre- preventing tumor generation and take off the diffusion and life of tumour processed It is long.
Lily：It is sweet, it trembles with fear, distributed in heart and lung channels, Yin nourishing and lung moistening, clearing away the heart fire and tranquillizing, for deficiency of Yin cough caused by dryness, overstrain cough hemoptysis, Virtual is tired of frightened Throb with fear, insomnia and dreamful sleep is absent-minded.Modern study finds that colchicin can inhibit the proliferation of cancer cell in lily.
The positive beneficial effect of the present invention：
1. each bulk pharmaceutical chemicals of the present invention are used cooperatively, giving consideration to both the incidental and fundamental, strengthening vital QI to eliminate pathogenic factors, oldenlandia diffusa, Asian puccoon and root bark of shaggy-fruited dittany heat-clearing solution Poison, it is antitumor；Curcuma zedoary and trigone promoting qi circulation and relieving pain, radix paeoniae rubrathe removing blood stasis and analgesics, curcuma zedoary, trigone and the radix paeoniae rubrathe share, and inrigorating qi and promoting blood circulation, stagnation resolvation stops Bitterly；Rhizoma Atractylodis Macrocephalae strengthening the spleen and replenishing qi, dried orange peel regulating qi-flowing for strengthening spleen, hawthorn appetite-stimulating and indigestion-relieving, Rhizoma Atractylodis Macrocephalae, dried orange peel and hawthorn share, and strengthening the spleen and replenishing qi, appetizing disappears Food promotes the absorption of above-mentioned each bulk pharmaceutical chemicals；Ganoderma lucidum and lily clearing away the heart fire and tranquillizing, it is antitumor, it is shared with each bulk pharmaceutical chemicals, except void solution is tired； The present invention each bulk pharmaceutical chemicals synergistic effect is mended without stagnant, is rushed down without void, and temperature of trembling with fear is suitable, the foster taste of temperature, heat-clearing dissipating bind, promoting blood circulation and stopping pain, The antitumor ability of body is improved, the transfer of tumour is reduced, extends the service life of tumor patient.
2. each raw material of the present invention is impregnated using ethyl alcohol and ultrasonic extraction, it is fully dissolved out convenient for active ingredient, extraction is thorough, Ultrasonic extraction temperature is low, reduces the destruction and loss of active ingredient, and extraction time is short, and extraction efficiency is high.
Specific embodiment
With reference to some specific embodiments, the present invention is further described.
Embodiment 1
A kind of antitumor drug is made of the bulk pharmaceutical chemicals of following parts by weight：
10 parts of oldenlandia diffusa, 20 parts of Asian puccoon, 18 parts of the root bark of shaggy-fruited dittany, 6 parts of curcuma zedoary, 8 parts of trigone, 15 parts of the radix paeoniae rubrathe, 10 parts of Rhizoma Atractylodis Macrocephalae, dried orange peel 12 parts of 15 parts, 10 parts of hawthorn, 20 parts of ganoderma lucidum and lily.
The preparation method of above-mentioned antitumor drug, includes the following steps：
（1）Various bulk pharmaceutical chemicals are mixed, are ground into the powder that grain size is 110 μm；
（2）By step（1）Powder impregnates 3h using 10 times of 50% ethyl alcohol of amount, and 20min, Extracting temperature are extracted in ultrasonic extraction tank It is 55 DEG C, ultrasonic power 500W, extracts 3 times, merges extracting solution；
（3）By step（2）Extracting solution filtering, concentration obtain the medicinal extract that relative density is 1.1, add in the paste for accounting for medicinal extract weight 10% Essence is uniformly mixed, and is dried in vacuo, and is crushed, and crosses 24 mesh sieve series grains, dress capsule to obtain the final product.
Embodiment 2
A kind of antitumor drug is made of the bulk pharmaceutical chemicals of following parts by weight：
It is 11 parts of oldenlandia diffusa, 22 parts of Asian puccoon, 19 parts of the root bark of shaggy-fruited dittany, 7 parts of curcuma zedoary, 9 parts of trigone, 15.7 parts of the radix paeoniae rubrathe, 11 parts of Rhizoma Atractylodis Macrocephalae, old 14 parts of 16 parts of skin, 11 parts of hawthorn, 21 parts of ganoderma lucidum and lily.
The preparation method of above-mentioned antitumor drug, includes the following steps：
（1）Various bulk pharmaceutical chemicals are mixed, are ground into the powder that grain size is 110 μm；
（2）By step（1）Powder impregnates 1h using 6 times of 75% ethyl alcohol of amount, 10min is extracted in ultrasonic extraction tank, Extracting temperature is It 52 DEG C, ultrasonic power 1000W, extracts 3 times, merges extracting solution；
（3）By step（2）Extracting solution filtering, concentration obtain the medicinal extract that relative density is 1.2, add in the breast for accounting for medicinal extract weight 15% Sugar is uniformly mixed, and is dried in vacuo, and is crushed, and crosses 32 mesh sieve series grains, dress capsule to obtain the final product.
Embodiment 3
A kind of antitumor drug is made of the bulk pharmaceutical chemicals of following parts by weight：
12 parts of oldenlandia diffusa, 24 parts of Asian puccoon, 19.5 parts of the root bark of shaggy-fruited dittany, 9 parts of curcuma zedoary, 10 parts of trigone, 16 parts of the radix paeoniae rubrathe, 12 parts of Rhizoma Atractylodis Macrocephalae, 18 parts of 18 parts of dried orange peel, 13 parts of hawthorn, 23.5 parts of ganoderma lucidum and lily.
The preparation method of above-mentioned antitumor drug, includes the following steps：
（1）Various bulk pharmaceutical chemicals are mixed, are ground into the powder that grain size is 150 μm；
（2）By step（1）Powder impregnates 2h using 8 times of 60% ethyl alcohol of amount, 15min is extracted in ultrasonic extraction tank, Extracting temperature is It 56 DEG C, ultrasonic power 800W, extracts 3 times, merges extracting solution；
（3）By step（2）Extracting solution filtering, concentration, obtain the medicinal extract that relative density is 1.23, and addition accounts for medicinal extract weight 20% Lactose is uniformly mixed, and is dried in vacuo, and is crushed, and crosses 30 mesh sieve series grains, dress capsule to obtain the final product.
Embodiment 4
A kind of antitumor drug is made of the bulk pharmaceutical chemicals of following parts by weight：
It is 13 parts of oldenlandia diffusa, 25 parts of Asian puccoon, 22 parts of the root bark of shaggy-fruited dittany, 10 parts of curcuma zedoary, 10 parts of trigone, 17 parts of the radix paeoniae rubrathe, 14 parts of Rhizoma Atractylodis Macrocephalae, old 20 parts of 20 parts of skin, 14 parts of hawthorn, 25 parts of ganoderma lucidum and lily.
The preparation method of above-mentioned antitumor drug, includes the following steps：
（1）Various bulk pharmaceutical chemicals are mixed, are ground into the powder that grain size is 120 μm；
（2）By step（1）Powder impregnates 3h using 8 times of 75% ethyl alcohol of amount, 25min is extracted in ultrasonic extraction tank, Extracting temperature is It 55 DEG C, ultrasonic power 600W, extracts 3 times, merges extracting solution；
（3）By step（2）Extracting solution filtering, concentration, obtain the medicinal extract that relative density is 1.22, and addition accounts for medicinal extract weight 15% Dextrin is uniformly mixed, and is dried in vacuo, and is crushed, and crosses 30 mesh sieve series grains, dress capsule to obtain the final product.
Embodiment 5
A kind of antitumor drug is made of the bulk pharmaceutical chemicals of following parts by weight：
13.5 parts of oldenlandia diffusa, 26 parts of Asian puccoon, 23 parts of the root bark of shaggy-fruited dittany, 11 parts of curcuma zedoary, 11 parts of trigone, 18 parts of the radix paeoniae rubrathe, 15 parts of Rhizoma Atractylodis Macrocephalae, 21 parts of 21 parts of dried orange peel, 15 parts of hawthorn, 27 parts of ganoderma lucidum and lily.
The preparation method of above-mentioned antitumor drug, includes the following steps：
（1）Various bulk pharmaceutical chemicals are mixed, are ground into the powder that grain size is 130 μm；
（2）By step（1）Powder impregnates 2h using 6 times of 80% ethyl alcohol of amount, 20min is extracted in ultrasonic extraction tank, Extracting temperature is It 53 DEG C, ultrasonic power 1000W, extracts 3 times, merges extracting solution；
（3）By step（2）Extracting solution filtering, concentration, obtain the medicinal extract that relative density is 1.25, and addition accounts for medicinal extract weight 10% Soluble starch is uniformly mixed, and is dried in vacuo, and is crushed, and crosses 28 mesh sieve series grains, dress capsule to obtain the final product.
Embodiment 6
A kind of antitumor drug is made of the bulk pharmaceutical chemicals of following parts by weight：
14 parts of oldenlandia diffusa, 27 parts of Asian puccoon, 25 parts of the root bark of shaggy-fruited dittany, 12 parts of curcuma zedoary, 12 parts of trigone, 18.5 parts of the radix paeoniae rubrathe, 16 parts of Rhizoma Atractylodis Macrocephalae, 23 parts of 23 parts of dried orange peel, 17 parts of hawthorn, 27 parts of ganoderma lucidum and lily.
The preparation method of above-mentioned antitumor drug, includes the following steps：
（1）Various bulk pharmaceutical chemicals are mixed, are ground into the powder that grain size is 140 μm；
（2）By step（1）Powder impregnates 1h using 9 times of 90% ethyl alcohol of amount, 10min is extracted in ultrasonic extraction tank, Extracting temperature is It 52 DEG C, ultrasonic power 700W, extracts 2 times, merges extracting solution；
（3）By step（2）Extracting solution filtering, concentration obtain the medicinal extract that relative density is 1.3, add in the breast for accounting for medicinal extract weight 20% Sugar is uniformly mixed, and is dried in vacuo, and is crushed, and crosses 40 mesh sieve series grains, dress capsule to obtain the final product.
Embodiment 7
A kind of antitumor drug is made of the bulk pharmaceutical chemicals of following parts by weight：
14 parts of oldenlandia diffusa, 28.2 parts of Asian puccoon, 27 parts of the root bark of shaggy-fruited dittany, 13 parts of curcuma zedoary, 14 parts of trigone, 19 parts of the radix paeoniae rubrathe, 18 parts of Rhizoma Atractylodis Macrocephalae, 25 parts of 24 parts of dried orange peel, 18 parts of hawthorn, 29 parts of ganoderma lucidum and lily.
The preparation method of above-mentioned antitumor drug, includes the following steps：
（1）Various bulk pharmaceutical chemicals are mixed, are ground into the powder that grain size is 100 μm；
（2）By step（1）Powder impregnates 2h using 10 times of 90% ethyl alcohol of amount, and 30min, Extracting temperature are extracted in ultrasonic extraction tank It is 57 DEG C, ultrasonic power 500W, extracts 2 times, merges extracting solution；
（3）By step（2）Extracting solution filtering, concentration, obtain the medicinal extract that relative density is 1.18, and addition accounts for medicinal extract weight 12% Dextrin is uniformly mixed, and is dried in vacuo, and is crushed, and crosses 35 mesh sieve series grains, dress capsule to obtain the final product.
Embodiment 8
A kind of antitumor drug is made of the bulk pharmaceutical chemicals of following parts by weight：
It is 15 parts of oldenlandia diffusa, 30 parts of Asian puccoon, 28 parts of the root bark of shaggy-fruited dittany, 13 parts of curcuma zedoary, 15 parts of trigone, 20 parts of the radix paeoniae rubrathe, 20 parts of Rhizoma Atractylodis Macrocephalae, old 26 parts of 25 parts of skin, 20 parts of hawthorn, 30 parts of ganoderma lucidum and lily.
The preparation method of above-mentioned antitumor drug, includes the following steps：
（1）Various bulk pharmaceutical chemicals are mixed, are ground into the powder that grain size is 110 μm；
（2）By step（1）Powder impregnates 2h using 7 times of 70% ethyl alcohol of amount, 20min is extracted in ultrasonic extraction tank, Extracting temperature is It 55 DEG C, ultrasonic power 800W, extracts 3 times, merges extracting solution；
（3）By step（2）Extracting solution filtering, concentration obtain the medicinal extract that relative density is 1.3, add in account for medicinal extract weight 20% can Soluble starch is uniformly mixed, and is dried in vacuo, and is crushed, and crosses 40 mesh sieve series grains, dress capsule to obtain the final product.
1. pharmacodynamic experiment
Main experimental reagent：Murine Hepatoma22 knurl strain, mouse peritoneal passage；
Experimental animal：Kunming mouse 50, SPF grades, half male and half female, 20 ± 1g of weight is randomly divided into 5 groups, i.e. blank group, mould Type group, high dose group, middle dose group and low dose group, every group 10；
The duplication of animal model：The sterile working on superclean bench takes lotus liver cancer（H22）Mouse ascites, with 0.9% physiology salt Water is diluted to containing oncocyte 2 × 106A/ml per the right armpit notch graft 0.2m1 of mouse, replicates tumor model；
Test method：Blank group gavages physiological saline, and model group inoculation knurl strain simultaneously gavages physiological saline；High dose group, middle dosage Group and low dose group are inoculated with knurl strain and gastric infusion respectively, and medication is：It is anti-swollen using the distilled water dilution embodiment of the present invention 4 Tumor medicine, high dose group, middle dose group and low dose group drug concentration are respectively 0.5g/ml, 0.25g/ml, 0.125g/ml, are pressed 0.2ml/10g weight gastric infusions, 2 times a day.After treating 2 weeks, the neck that breaks puts to death mouse, calculates different disposal method to H22 lotuses The tumour inhibiting rate of knurl mouse, experimental result are shown in Table 1.
Tumour inhibiting rate/%=（Model group average knurl weight-experimental group average knurl weight）/ model group average knurl weight × 100%
Table 1 is to the tumour inhibiting rate of H22 tumor-bearing mices
As shown in Table 1：Compared with model group, high dose group, middle dose group and low dose group solid tumor quality have decline, especially High dose group and middle dose group decline significantly, and high dose group, middle dose group and low dosage tumour inhibiting rate are respectively 58.7%, 40.6% and 31.5%, illustrate that antitumor drug tumor killing effect of the present invention is good.
2. toxicity test
Test method：（1）Kunming mouse 30, SPF grades, half male and half female, 20 ± 1g of weight is randomly divided into 3 groups, high dose Group, middle dose group and low dose group, every group 10；
4 antitumor drug of the embodiment of the present invention, high dose group, middle dose group, low dose group administration concentration are diluted using distilled water Respectively 0.5g/ml, 0.25g/ml, 0.125g/ml, fasting 12 hours before administration, by 0.4ml/10g weight gastric infusions, one It day 2 times observes 2 weeks, as a result without dead mouse, does not measure LD50, determine that by 0.5g/ml be orthogonal test.
（2）Another to take 20 mouse, SPF grades, half male and half female, 20 ± 1g of weight is randomly divided into experimental group and control group, every group 10, experimental group uses 4 antitumor drug of the embodiment of the present invention, a concentration of 0.5g/ml of drug is diluted using distilled water, before administration Fasting 12 hours by 0.4ml/10g weight gastric infusions, 2 times a day, is administered 2 weeks, and control group gives physiological saline, and observation is small The hair of mouse, activity, feed, excretion, death condition.
Test results and analysis：Do not find animal dead after 2 weeks, experimental group and control group mice hair, activity, feed, Indifference in terms of excretion, weight increase to 30 ± 1.8g by testing preceding 20 ± 1g, and weight gain is apparent；Animal is put to death after 2 weeks, is solved It cuts open, visually observes the main organs such as the heart, liver, spleen, lung, kidney and show no obvious abnormalities change.Therefore, antitumor drug gavage of the present invention Maximum dose on the one of administration is 40g/Kg（0.5g/ml × 0.4ml/10g × 2 times/day=40g/Kg）, it is every to be equivalent to adult Consumption per day（3 tablets/time × 3 times/day × 0.4g/ ÷ 60kg=0.06g/Kg）667 times, have no apparent acute toxic reaction.

Claims (7)

1. a kind of antitumor drug, which is characterized in that be made of the bulk pharmaceutical chemicals of following parts by weight：
10-15 parts of oldenlandia diffusa, 20-30 parts of Asian puccoon, 18-28 parts of the root bark of shaggy-fruited dittany, 6-13 parts of curcuma zedoary, 8-15 parts of trigone, radix paeoniae rubrathe 15- 12-26 parts of 20 parts, 10-20 parts of Rhizoma Atractylodis Macrocephalae, 15-25 parts of dried orange peel, 10-20 parts of hawthorn, 20-30 parts of ganoderma lucidum and lily.
2. antitumor drug according to claim 1, which is characterized in that be made of the bulk pharmaceutical chemicals of following parts by weight：
12-14 parts of oldenlandia diffusa, 24-27 parts of Asian puccoon, 19.5-25 parts of the root bark of shaggy-fruited dittany, 9-12 parts of curcuma zedoary, 10-12 parts of trigone, the radix paeoniae rubrathe 18-23 parts of 16-18.5 parts, 12-16 parts of Rhizoma Atractylodis Macrocephalae, 18-23 parts of dried orange peel, 13-17 parts of hawthorn, 23.5-27 parts of ganoderma lucidum and lily.
3. antitumor drug according to claim 2, which is characterized in that be made of the bulk pharmaceutical chemicals of following parts by weight：
It is 13 parts of oldenlandia diffusa, 25 parts of Asian puccoon, 22 parts of the root bark of shaggy-fruited dittany, 10 parts of curcuma zedoary, 10 parts of trigone, 17 parts of the radix paeoniae rubrathe, 14 parts of Rhizoma Atractylodis Macrocephalae, old 20 parts of 20 parts of skin, 14 parts of hawthorn, 25 parts of ganoderma lucidum and lily.
4. a kind of preparation method of claim 1-3 any one of them antitumor drugs, which is characterized in that including following step Suddenly：
（1）Various bulk pharmaceutical chemicals are mixed, are ground into 100-150 μm of powder；
（2）By step（1）Powder measures ethyl alcohol using 5-10 times and impregnates 1-3h, and 10-30min is extracted in ultrasonic extraction tank, is extracted 2-3 times, merge extracting solution；
（3）By step（2）Extracting solution filtering, concentration, obtain the medicinal extract that relative density is 1.1-1.3, and addition accounts for medicinal extract weight 10- 20% auxiliary material is uniformly mixed, and is dried in vacuo, and is crushed, and crosses 20-40 mesh sieve series grains, dress capsule to obtain the final product.
5. the preparation method of antitumor drug according to claim 4, which is characterized in that step（2）The ethyl alcohol volume Score is 50%-90%.
6. the preparation method of antitumor drug according to claim 4, which is characterized in that step（2）The Extracting temperature It is 52-57 DEG C, ultrasonic power 500-1000W.
7. the preparation method of antitumor drug according to claim 4, which is characterized in that step（3）The auxiliary material is paste Essence, lactose or soluble starch.
CN201810253859.1A 2018-03-26 2018-03-26 A kind of antitumor drug and preparation method thereof Withdrawn CN108186993A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106177792A (en) * 2016-08-29 2016-12-07 王建斌 A kind of Chinese medicine composition treating tumor and preparation method thereof
WO2017020280A1 (en) * 2015-08-05 2017-02-09 浙江众康药业有限公司 Uses of composition comprising polygonum capitatum and coptis roots in preparation of drugs for treating gastritis

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017020280A1 (en) * 2015-08-05 2017-02-09 浙江众康药业有限公司 Uses of composition comprising polygonum capitatum and coptis roots in preparation of drugs for treating gastritis
CN106177792A (en) * 2016-08-29 2016-12-07 王建斌 A kind of Chinese medicine composition treating tumor and preparation method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
张彦: "《常见肿瘤的中西医结合治疗》", 31 January 2014, 天津科学技术出版社 *
王守峰等: "肝舒合剂治疗晚期肝癌的临床研究", 《滨州医学院学报》 *

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Application publication date: 20180622