CN108186454B - Moisturizing composition and application thereof in cosmetics - Google Patents
Moisturizing composition and application thereof in cosmetics Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
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- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
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- A61Q19/007—Preparations for dry skin
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Abstract
The invention discloses a moisturizing composition and application thereof in cosmetics. The traditional Chinese medicine is prepared from the following raw materials in parts by weight: 50-100 parts of hyaluronic acid, 20-40 parts of jojoba oil, 10-30 parts of shea butter, 5-8 parts of plant protein, 5-8 parts of animal protein, 30-50 parts of Cunninghamia lanceolata, 20-30 parts of Elaeagnus dulcis, 20-30 parts of orange peel and 20-30 parts of helichrysum. The moisturizing composition prepared by the invention has a good moisturizing effect on skin, can keep the skin moist for a long time after being used, has a treatment effect on patients with dry skin, is low in recurrence rate after being cured, is a pharmaceutical composition capable of radically changing the skin state of patients with dry skin, and has a wide application prospect.
Description
Technical Field
The invention belongs to the technical field of humectant preparation, and particularly relates to a moisturizing composition and application thereof in cosmetics.
Background
The humectant is used for simulating a natural moisturizing system consisting of oil, water and NMF in human skin, and has the functions of delaying water loss, increasing dermis-epidermis water permeation, temporarily protecting the skin, reducing injury and promoting a repair process. The humectant has countless formulas, and different components can be combined to prepare a plurality of good humectants. Cosmetic companies instill a concept that specific ingredients can solve all skin problems, whether vitamin C, green tea, grape extract, seaweed, beta glucan, fruit acid, or fungus extract, etc., although each has a specific function, none of them can guarantee no wrinkles after use, and no research has confirmed which ingredient is the best.
Patent 201510272812.6 discloses a Chinese herbal medicine skin moisturizer and a preparation method thereof, wherein the Chinese herbal medicine skin moisturizer comprises the following Chinese herbal medicine raw materials in parts by weight: 20-35 parts of rehmannia root, 20-35 parts of bletilla striata, 10-20 parts of glossy privet fruit and 10-20 parts of Chinese yam. The Chinese herbal medicine skin moisturizer is used for symptomatic treatment, and regulates the kidney and spleen of a human body from internal causes of dry skin so as to achieve the effects of promoting the production of body fluid, moisturizing the skin, nourishing yin and tonifying the kidney. Patent 201510402380.6 discloses a skin moisturizing treatment agent, which comprises the following components: moisturizing composition, fatty acid ester, cyclic silicone oil, isopropyl palmitate, lecithin, dihydric phenol, palmitic acid, carbomer, glycerol, triethanolamine, butanediol, luba gum oil, olive oil, and sodium hyaluronate. The components of the moisturizing composition are as follows: bamboo extract, seaweed composite extract, thyme extract, ginseng root extract, cinnamon extract, garlic extract, butanediol, preservative and water. The moisturizing composition and the moisturizing cream and the caring agent prepared from the moisturizing composition have the effects of caring dry skin and slowing down skin moisture loss by comprehensively moisturizing skin aiming at the reason of skin aging. However, the moisturizers are temporary for skin care, and after the moisturizers are taken out of service, the skin quickly returns to a dry state, and many more serious side effects are caused.
Disclosure of Invention
The invention aims to provide a moisturizing composition and application thereof in cosmetics.
The moisturizing composition is prepared from the following raw materials in parts by weight: 50-100 parts of hyaluronic acid, 20-40 parts of jojoba oil, 10-30 parts of shea butter, 5-8 parts of plant protein, 5-8 parts of animal protein, 30-50 parts of Cunninghamia lanceolata, 20-30 parts of Elaeagnus dulcis, 20-30 parts of orange peel and 20-30 parts of helichrysum.
The vegetable protein is one or more of soybean protein, hemp protein, wheat protein and rice protein.
The animal protein is one or more of collagen, fish protein, fibroin and casein.
The preparation raw materials of the moisturizing composition also comprise 20-30 parts of the Grignard thorn branches.
The preparation raw materials of the moisturizing composition also comprise 20-30 parts of polygonum hydropiper.
The preparation method of the moisturizing composition comprises the following steps:
(1) mixing 30-50 parts of Cunninghamia lanceolata and 20-30 parts of Elaeagnus dulcis, grinding into powder, adding 3-5 times of 75% ethanol, reflux-extracting for 1-5 times, mixing filtrates, and concentrating to obtain extract A;
(2) taking 20-30 parts of orange peel and 20-30 parts of helichrysum, putting into a casserole, immersing with water, heating to 60-80 ℃, cooking for 1-3 hours, adding 2 parts of potassium tartrate, cooking for 6-8 hours, cooling to room temperature, standing for 1-3 hours, taking supernatant, and concentrating into an extract B;
(3) mixing hyaluronic acid 50-100 parts, jojoba oil 20-40 parts, shea butter 10-30 parts, vegetable protein 5-8 parts, animal protein 5-8 parts, extract A and extract B uniformly.
20-30 parts of Grignard thorn branches are also added in the step (1).
20-30 parts of polygonum hydropiper is also added in the step (2).
Use of the above moisturizing composition as a cosmetic additive.
The invention has the beneficial effects that: the moisturizing composition prepared by the invention has a good moisturizing effect on skin, can keep the skin moist for a long time after being used, has a treatment effect on patients with dry skin, is low in recurrence rate after being cured, is a pharmaceutical composition capable of radically changing the skin state of patients with dry skin, and has a wide application prospect.
Detailed Description
The present invention is further illustrated by the following specific examples.
Example 1
The moisturizing composition is prepared from the following raw materials in parts by weight: 80 parts of hyaluronic acid, 30 parts of jojoba oil, 20 parts of shea butter, 6 parts of soybean protein, 6 parts of collagen, 40 parts of algae of Cunninghamia lanceolata, 25 parts of Elaeagnus dulcis, 25 parts of orange peel and 25 parts of helichrysum.
The preparation method of the moisturizing composition comprises the following steps:
(1) mixing and grinding 40 parts of Cunninghamia lanceolata and 25 parts of Elaeagnus dulcis into powder, adding 4 times of 75% ethanol by weight, reflux-extracting for 3 times, mixing filtrates, and concentrating to obtain extract A;
(2) taking 25 parts of orange peel and 25 parts of helichrysum, putting the orange peel and the helichrysum into a marmite, immersing the orange peel and the helichrysum in water, heating the mixture to 70 ℃, cooking the mixture for 2 hours, adding 2 parts of potassium tartrate, cooking the mixture for 7 hours, cooling the mixture to room temperature, standing the mixture for 2 hours, taking supernatant, and concentrating the supernatant into an extract B;
(3) mixing hyaluronic acid 80 parts, jojoba oil 30 parts, shea butter 20 parts, soybean protein 6 parts, collagen 6 parts, extract A and extract B uniformly to obtain the product.
Example 2
The moisturizing composition is prepared from the following raw materials in parts by weight: 50 parts of hyaluronic acid, 20 parts of jojoba oil, 10 parts of shea butter, 5 parts of wheat protein, 5 parts of fibroin, 30 parts of Cunninghamia lanceolata, 20 parts of Elaeagnus dulcis, 20 parts of orange peel and 20 parts of helichrysum.
The preparation method of the moisturizing composition comprises the following steps:
(1) mixing 30 parts of Cunninghamia lanceolata and 20 parts of Elaeagnus dulcis, grinding into powder, adding 3 times of 75% ethanol by weight, reflux-extracting for 1 time, and concentrating to obtain extract A;
(2) taking 20 parts of orange peel and 20 parts of helichrysum, putting into a marmite, immersing with water, heating to 60 ℃, cooking for 1 hour, adding 2 parts of potassium tartrate, cooking for 6 hours, cooling to room temperature, standing for 1 hour, taking supernatant, and concentrating into an extract B;
(3) taking 50 parts of hyaluronic acid, 20 parts of jojoba oil, 10 parts of shea butter, 5 parts of wheat protein, 5 parts of fibroin, an extract A and an extract B, and uniformly mixing to prepare the hyaluronic acid.
Example 3
The moisturizing composition is prepared from the following raw materials in parts by weight: 100 parts of hyaluronic acid, 40 parts of jojoba oil, 30 parts of shea butter, 8 parts of rice protein, 8 parts of casein, 50 parts of Cunninghamia lanceolata, 30 parts of Elaeagnus dulcis, 30 parts of orange peel and 30 parts of helichrysum.
The preparation method of the moisturizing composition comprises the following steps:
(1) taking 50 parts of algae of Cunninghamia lanceolata and 30 parts of Elaeagnus dulcis, mixing, grinding into powder, adding 5 times of 75% ethanol by weight, reflux-extracting for 5 times, combining filtrates, and concentrating to obtain extract A;
(2) taking 30 parts of orange peel and 30 parts of helichrysum, putting the orange peel and the helichrysum into a marmite, immersing the orange peel and the helichrysum in water, heating the mixture to 80 ℃, cooking the mixture for 3 hours, adding 2 parts of potassium tartrate, cooking the mixture for 8 hours, cooling the mixture to room temperature, standing the mixture for 3 hours, taking supernatant, and concentrating the supernatant into an extract B;
(3) mixing hyaluronic acid 100 parts, jojoba oil 40 parts, shea butter 30 parts, rice protein 8 parts, casein 8 parts, extract A and extract B uniformly.
Example 4
The moisturizing composition is prepared from the following raw materials in parts by weight: 80 parts of hyaluronic acid, 30 parts of jojoba oil, 20 parts of shea butter, 6 parts of soybean protein, 6 parts of collagen, 40 parts of microcystis lanceolata, 25 parts of Elaeagnus dulcis, 25 parts of orange peel, 25 parts of helichrysum and 25 parts of Grignard thorn branches.
The preparation method of the moisturizing composition comprises the following steps:
(1) mixing and grinding 40 parts of Cunninghamia lanceolata and 25 parts of Elaeagnus dulcis into powder, adding 4 times of 75% ethanol by weight, reflux-extracting for 3 times, mixing filtrates, and concentrating to obtain extract A;
(2) taking 25 parts of orange peel, 25 parts of helichrysum and 25 parts of Grignard thorn branches, putting the orange peel, the helichrysum and the Grignard thorn branches into a marmite, immersing the mixture in water, heating the mixture to 70 ℃, cooking the mixture for 2 hours, adding 2 parts of potassium tartrate, cooking the mixture for 7 hours, cooling the mixture to room temperature, standing the mixture for 2 hours, taking supernatant, and concentrating the supernatant into an extract B;
(3) mixing hyaluronic acid 80 parts, jojoba oil 30 parts, shea butter 20 parts, soybean protein 6 parts, collagen 6 parts, extract A and extract B uniformly to obtain the product.
Example 5
The moisturizing composition is prepared from the following raw materials in parts by weight: 80 parts of hyaluronic acid, 30 parts of jojoba oil, 20 parts of shea butter, 6 parts of soybean protein, 6 parts of collagen, 40 parts of algae of Cunninghamia lanceolata, 25 parts of Elaeagnus dulcis, 25 parts of orange peel, 25 parts of herba Sedi Sarmentosi and 25 parts of Dayezhi branch.
The preparation method of the moisturizing composition comprises the following steps:
(1) mixing and grinding 40 parts of Cunninghamia lanceolata and 25 parts of Elaeagnus dulcis into powder, adding 4 times of 75% ethanol by weight, reflux-extracting for 3 times, mixing filtrates, and concentrating to obtain extract A;
(2) taking 25 parts of orange peel, 25 parts of chrysanthemum morifolium and 25 parts of thorny rageentree branch, putting the orange peel, the chrysanthemum morifolium and the thorny rageentree branch into a marmite, immersing the orange peel, heating the orange peel to 70 ℃, cooking the orange peel for 2 hours, adding 2 parts of potassium tartrate, cooking the orange peel for 7 hours, cooling the orange peel to room temperature, standing the orange peel for 2 hours, taking supernatant fluid, and concentrating the supernatant fluid into an extract B;
(3) mixing hyaluronic acid 80 parts, jojoba oil 30 parts, shea butter 20 parts, soybean protein 6 parts, collagen 6 parts, extract A and extract B uniformly to obtain the product.
Example 6
The moisturizing composition is prepared from the following raw materials in parts by weight: 80 parts of hyaluronic acid, 30 parts of jojoba oil, 20 parts of shea butter, 6 parts of soybean protein, 6 parts of collagen, 40 parts of microcystis microti, 25 parts of herba solani dulcis, 25 parts of orange peel, 25 parts of herba tassel flower and 25 parts of polygonum hydropiper.
The preparation method of the moisturizing composition comprises the following steps:
(1) mixing and grinding 40 parts of Cunninghamia lanceolata and 25 parts of Elaeagnus dulcis into powder, adding 4 times of 75% ethanol by weight, reflux-extracting for 3 times, mixing filtrates, and concentrating to obtain extract A;
(2) taking 25 parts of orange peel, 25 parts of chrysanthemum morifolium and 25 parts of polygonum orientale, putting the orange peel, the chrysanthemum morifolium and the polygonum orientale into a marmite, immersing the mixture in water, heating the mixture to 70 ℃, cooking the mixture for 2 hours, adding 2 parts of potassium tartrate, cooking the mixture for 7 hours, cooling the mixture to room temperature, standing the mixture for 2 hours, taking supernatant, and concentrating the supernatant into an extract B;
(3) mixing hyaluronic acid 80 parts, jojoba oil 30 parts, shea butter 20 parts, soybean protein 6 parts, collagen 6 parts, extract A and extract B uniformly to obtain the product.
Example 7
The moisturizing composition is prepared from the following raw materials in parts by weight: 80 parts of hyaluronic acid, 30 parts of jojoba oil, 20 parts of shea butter, 6 parts of soybean protein, 6 parts of collagen, 40 parts of Cunninghamia lanceolata, 25 parts of Elaeagnus dulcis, 25 parts of orange peel, 25 parts of herba Sedi Sarmentosi and 25 parts of boea bipinnata.
The preparation method of the moisturizing composition comprises the following steps:
(1) mixing and grinding 40 parts of Cunninghamia lanceolata and 25 parts of Elaeagnus dulcis into powder, adding 4 times of 75% ethanol by weight, reflux-extracting for 3 times, mixing filtrates, and concentrating to obtain extract A;
(2) taking 25 parts of orange peel, 25 parts of tassel flower and 25 parts of boea crassifolia, putting the raw materials into a marmite, immersing the raw materials in water, heating the raw materials to 70 ℃, cooking the raw materials for 2 hours, adding 2 parts of potassium tartrate, cooking the raw materials for 7 hours, cooling the raw materials to room temperature, standing the mixture for 2 hours, taking supernatant, and concentrating the supernatant into an extract B;
(3) mixing hyaluronic acid 80 parts, jojoba oil 30 parts, shea butter 20 parts, soybean protein 6 parts, collagen 6 parts, extract A and extract B uniformly to obtain the product.
Comparative example 1
The moisturizing composition is prepared from the following raw materials in parts by weight: 80 parts of hyaluronic acid, 30 parts of jojoba oil, 20 parts of shea butter, 6 parts of soybean protein, 6 parts of collagen, 25 parts of Elaeagnus dulcis, 25 parts of orange peel and 25 parts of helichrysum.
The preparation method of the moisturizing composition comprises the following steps:
(1) taking 25 parts of Elaeagnus dulcis, mixing, grinding into powder, adding 4 times of 75% ethanol by weight, performing reflux extraction for 3 times, combining filtrates, and concentrating to obtain an extract A;
(2) taking 25 parts of orange peel and 25 parts of helichrysum, putting the orange peel and the helichrysum into a marmite, immersing the orange peel and the helichrysum in water, heating the mixture to 70 ℃, cooking the mixture for 2 hours, adding 2 parts of potassium tartrate, cooking the mixture for 7 hours, cooling the mixture to room temperature, standing the mixture for 2 hours, taking supernatant, and concentrating the supernatant into an extract B;
(3) mixing hyaluronic acid 80 parts, jojoba oil 30 parts, shea butter 20 parts, soybean protein 6 parts, collagen 6 parts, extract A and extract B uniformly to obtain the product.
Experimental example 1 moisture absorption experiment
Accurately weighing two parts of the above samples, adding into a weighing bottle with the diameter of 3cm, placing each part of the sample into two driers, respectively, placing saturated ammonium sulfate solution (relative humidity R H is 81%) into one drier, placing saturated sodium carbonate solution (RH is 43%) into the other drier, and standing for 24h, respectively weighing the mass of the sample before standing (W is weight of the sample after standing)0) And mass after standing (W)n) The moisture absorption rate was calculated according to the following formula:
moisture absorption rate (%) < 100 (W)n－W0)/W0The results are shown in table 1:
TABLE 1
As can be seen from table 1, the moisture absorption rate of comparative example 1 is significantly lower than that of example 1, and compared with example 1, other conditions are completely the same, only the addition of the small amount of the alga taxus chinensis in comparative example 1, and thus, the alga taxus chinensis has the effect of enhancing the moisture absorption rate of the moisturizing composition; the moisture absorption rate of example 4 is obviously higher than that of example 1, the moisture absorption rate of example 5 is equivalent to that of example 1, compared with example 1, other experimental conditions are completely the same, more Grignard ratchet branches are added in example 4, more big-leaf ratchet branches are added in example 5, and the Grignard ratchet branches have the effect of enhancing the moisture absorption rate of the moisturizing composition, but the big-leaf ratchet branches do not have the effect; the moisture absorption rates of the example 6 and the example 7 are obviously higher than that of the example 1, and compared with the example 1, other conditions are completely the same, only the polygonum orientale is added in more in the example 6, and the polygonum orientale and the capsule moss is added in more in the example 7, so that the polygonum orientale and the capsule moss have the efficacy of enhancing the moisture absorption rate of the moisturizing composition.
Experimental example 2 moisturizing experiment
Accurately weighing a sample at room temperature, placing into a weighing bottle with a diameter of 3cm, adding deionized water with a mass fraction of 40% of the sample amount, placing in a dryer filled with dry silica gel for 24H, and respectively weighing the water content (H) after the sample is placedn) And the amount of added water (H)0) The moisture retention rate was calculated according to the following formula:
moisture retention rate (%) > 100Hn/H0
The results are shown in table 2:
TABLE 2
As can be seen from table 2, the moisture retention rate of comparative example 1 is significantly lower than that of example 1, and compared with example 1, other conditions are completely the same, only the addition of the alga taxus chinensis is less in comparative example 1, and thus, the alga taxus chinensis has the efficacy of enhancing the moisture retention rate of the moisture retention composition; the moisturizing rate of the example 4 is obviously higher than that of the example 1, the example 5 is equivalent to the example 1, compared with the example 1, other experimental conditions are completely the same, more Grignard ratchet branches are added in the example 4, more big-leaf ratchet branches are added in the example 5, and the Grignard ratchet branches have the efficacy of enhancing the moisturizing rate of the moisturizing composition, but the big-leaf ratchet branches do not have the efficacy; the moisture retention rates of the example 6 and the example 7 are obviously higher than that of the example 1, and compared with the example 1, other conditions are completely the same, only the polygonum orientale is added in more in the example 6, and the capsule moss of the polygonum orientale is added in more in the example 7, so that the polygonum orientale and the capsule moss of the polygonum bidentate have the efficacy of enhancing the moisture retention rate of the moisture retention composition.
Experimental example 3 skin dryness recovery experiment
800 persons with moderate dry skin are selected, the age is 35-45 years old, and the female has the symptoms: the skin has mixed scales, silvery white localized flushing or diffuse red irregular or rough skin on the surface, slight stiffness feeling when the skin is touched vertically, and superficial chapping plus a few deep cracks. Applying the moisturizing compositions of examples 1-7 and comparative example 1, applying 10g of the moisturizing composition to the affected part daily, applying the moisturizing composition to the affected part with an area of 0.2 square meter, continuously applying the moisturizing composition for 60 days, recovering the skin to be moist, curing the elasticity, counting the cure rate, and counting the recurrence rate after 30 days of disuse, wherein the results are shown in Table 3:
TABLE 3
As can be seen from table 3, the cure rate of comparative example 1 is significantly lower than that of example 1, the recurrence rate is significantly higher than that of example 1, and compared with example 1, other conditions are completely the same, only the addition of the small amount of the algae of the cunninghamia lanceolata in comparative example 1 is small, and thus, the algae of the cunninghamia lanceolata has the efficacy of curing dry skin diseases; the cure rate of example 4 is obviously higher than that of example 1, the recurrence rate is obviously lower than that of example 1, example 5 is equivalent to example 1, compared with example 1, other experimental conditions are completely the same, more Grignard thorn branches are added in example 4, more big-leaf thorn branches are added in example 5, and the Grignard thorn branches have the effect of curing dry skin diseases, but the big-leaf thorn branches do not have the effect; the cure rate of the example 6 and the example 7 is obviously higher than that of the example 1, the relapse rate is obviously lower than that of the example 1, and compared with the example 1, other conditions are completely the same, only the polygonum hydropiper is added in the example 6, and the capsule moss of the bidentate achyranthes root is added in the example 7, so that the polygonum hydropiper and the capsule moss of the bidentate achyranthes root have the efficacy of curing the dry skin disease.
Claims (1)
1. The moisturizing composition is characterized by being prepared from the following raw materials in parts by weight: 80 parts of hyaluronic acid, 30 parts of jojoba oil, 20 parts of shea butter, 6 parts of soybean protein, 6 parts of collagen, 40 parts of microcystis lanceolata, 25 parts of dulcamara, 25 parts of orange peel, 25 parts of tassel flower and 25 parts of Grignard thorn branches;
the preparation method of the moisturizing composition comprises the following steps:
(1) mixing and grinding 40 parts of Cunninghamia lanceolata and 25 parts of Elaeagnus dulcis into powder, adding 4 times of 75% ethanol by weight, reflux-extracting for 3 times, mixing filtrates, and concentrating to obtain extract A;
(2) taking 25 parts of orange peel, 25 parts of helichrysum and 25 parts of Grignard thorn branches, putting the orange peel, the helichrysum and the Grignard thorn branches into a marmite, immersing the mixture in water, heating the mixture to 70 ℃, cooking the mixture for 2 hours, adding 2 parts of potassium tartrate, cooking the mixture for 7 hours, cooling the mixture to room temperature, standing the mixture for 2 hours, taking supernatant, and concentrating the supernatant into an extract B;
(3) mixing hyaluronic acid 80 parts, jojoba oil 30 parts, shea butter 20 parts, soybean protein 6 parts, collagen 6 parts, extract A and extract B uniformly to obtain the product.
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| CN105434205A (en) * | 2014-11-08 | 2016-03-30 | 马南行 | Composition for quickly smoothening eye wrinkles and delaying senescence and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105434205A (en) * | 2014-11-08 | 2016-03-30 | 马南行 | Composition for quickly smoothening eye wrinkles and delaying senescence and preparation method thereof |
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