CN108159733B - 氧化锆模块调节 - Google Patents

氧化锆模块调节 Download PDF

Info

Publication number
CN108159733B
CN108159733B CN201711179516.7A CN201711179516A CN108159733B CN 108159733 B CN108159733 B CN 108159733B CN 201711179516 A CN201711179516 A CN 201711179516A CN 108159733 B CN108159733 B CN 108159733B
Authority
CN
China
Prior art keywords
zirconia
module
flow path
sorbent
solution
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN201711179516.7A
Other languages
English (en)
Other versions
CN108159733A (zh
Inventor
克里斯多夫·M·霍博特
布莱恩特·J·普迪尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medtronic Inc
Original Assignee
Medtronic Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medtronic Inc filed Critical Medtronic Inc
Publication of CN108159733A publication Critical patent/CN108159733A/zh
Application granted granted Critical
Publication of CN108159733B publication Critical patent/CN108159733B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/34—Regenerating or reactivating
    • B01J20/345—Regenerating or reactivating using a particular desorbing compound or mixture
    • B01J20/3475—Regenerating or reactivating using a particular desorbing compound or mixture in the liquid phase
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
    • A61L2/0088—Liquid substances
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1601—Control or regulation
    • A61M1/1603—Regulation parameters
    • A61M1/1605—Physical characteristics of the dialysate fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/168—Sterilisation or cleaning before or after use
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
    • A61M1/1694—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid
    • A61M1/1696—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes with recirculating dialysing liquid with dialysate regeneration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/0203—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of metals not provided for in B01J20/04
    • B01J20/0211—Compounds of Ti, Zr, Hf
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/0203—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of metals not provided for in B01J20/04
    • B01J20/0274—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising compounds of metals not provided for in B01J20/04 characterised by the type of anion
    • B01J20/0292—Phosphates of compounds other than those provided for in B01J20/048
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/02—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material
    • B01J20/06—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising inorganic material comprising oxides or hydroxides of metals not provided for in group B01J20/04
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
    • B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
    • B01J20/28052—Several layers of identical or different sorbents stacked in a housing, e.g. in a column
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
    • B01J20/30—Processes for preparing, regenerating, or reactivating
    • B01J20/34—Regenerating or reactivating
    • B01J20/3433—Regenerating or reactivating of sorbents or filter aids other than those covered by B01J20/3408 - B01J20/3425
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J49/00—Regeneration or reactivation of ion-exchangers; Apparatus therefor
    • B01J49/05—Regeneration or reactivation of ion-exchangers; Apparatus therefor of fixed beds
    • B01J49/07—Regeneration or reactivation of ion-exchangers; Apparatus therefor of fixed beds containing anionic exchangers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J49/00—Regeneration or reactivation of ion-exchangers; Apparatus therefor
    • B01J49/05—Regeneration or reactivation of ion-exchangers; Apparatus therefor of fixed beds
    • B01J49/08—Regeneration or reactivation of ion-exchangers; Apparatus therefor of fixed beds containing cationic and anionic exchangers in separate beds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J49/00—Regeneration or reactivation of ion-exchangers; Apparatus therefor
    • B01J49/50—Regeneration or reactivation of ion-exchangers; Apparatus therefor characterised by the regeneration reagents
    • B01J49/57—Regeneration or reactivation of ion-exchangers; Apparatus therefor characterised by the regeneration reagents for anionic exchangers
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01B—NON-METALLIC ELEMENTS; COMPOUNDS THEREOF; METALLOIDS OR COMPOUNDS THEREOF NOT COVERED BY SUBCLASS C01C
    • C01B25/00—Phosphorus; Compounds thereof
    • C01B25/16—Oxyacids of phosphorus; Salts thereof
    • C01B25/26—Phosphates
    • C01B25/37—Phosphates of heavy metals
    • C01B25/372—Phosphates of heavy metals of titanium, vanadium, zirconium, niobium, hafnium or tantalum
    • C—CHEMISTRY; METALLURGY
    • C01—INORGANIC CHEMISTRY
    • C01G—COMPOUNDS CONTAINING METALS NOT COVERED BY SUBCLASSES C01D OR C01F
    • C01G25/00—Compounds of zirconium
    • C01G25/02—Oxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/10—Apparatus features
    • A61L2202/17—Combination with washing or cleaning means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2202/00—Aspects relating to methods or apparatus for disinfecting or sterilising materials or objects
    • A61L2202/20—Targets to be treated
    • A61L2202/24—Medical instruments, e.g. endoscopes, catheters, sharps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3324—PH measuring means
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M2205/00—General characteristics of the apparatus
    • A61M2205/33—Controlling, regulating or measuring
    • A61M2205/3331—Pressure; Flow

Abstract

本发明涉及用于调节再装填之后用于透析的氧化锆吸附剂模块的装置、系统和方法。所述装置、系统和方法能够在单一系统中或在独立系统中提供氧化锆的调节和再装填。

Description

氧化锆模块调节
相关申请交叉参考
本申请要求于2016年11月29日申请的美国临时专利申请第62/427,806号的权益和优先权，其全部公开内容以引用的方式并入本文中。
技术领域
本发明涉及用于调节在再装填之后用于透析的氧化锆吸附剂模块的装置、系统和方法。装置、系统和方法能够在单一系统中或在独立系统中提供氧化锆的调节和再装填。
背景技术
氧化锆用于吸附剂透析来从透析液去除阴离子废物并且捕集可能渗出磷酸锆吸附剂材料外的磷酸根离子。一般来说，在使用之后，氧化锆会被丢弃和替换。因为氧化锆昂贵而且可再装填，吸附剂再处理器可以将氧化锆用强碱溶液处理使得氧化锆材料能被再利用。
对于再处理，通常将氧化锆从吸附剂筒中移除，与其它吸附剂材料分离，用强碱处理，并且随后放入新吸附剂筒中。已知的再处理成本高而且是劳动密集的。
经强碱处理的氧化锆如果用在透析中会消耗全部碳酸盐，产生对患者不安全的碱性溶液。另外，为简化透析期间的碳酸氢盐控制，氧化锆和磷酸锆应处于平衡状态。
因此，需要调节再装填的氧化锆以使氧化锆处于适用于透析的状态中的系统和方法。另外需要能够再装填并调节吸附剂模块内氧化锆的系统和方法。此外需要调节再装填的氧化锆模块以达到与后续用于透析中的磷酸锆模块呈平衡状态的系统和方法。
发明内容
本发明的第一方面涉及一种调节氧化锆模块中的氧化锆的方法。在任何实施例中，方法可包含以下步骤：在流路中泵送调节溶液通过氧化锆模块以便调节氧化锆模块，其中调节溶液具有期望的氧化锆流出物pH值的碳酸氢钠。
在任何实施例中，方法可包含以下步骤：在通过泵送碱溶液通过氧化锆模块来调节氧化锆模块之前在氧化锆模块中再装填氧化锆。
在任何实施例中，方法可包含以下步骤：在泵送调节溶液通过氧化锆模块之前泵送调节溶液通过磷酸锆模块。
在任何实施例中，流路可以是包含磷酸锆模块和氧化锆模块的透析液流路。
在任何实施例中，流路可以是包含磷酸锆模块和氧化锆模块的再装填流路。
在任何实施例中，期望的氧化锆流出物pH值可在5.0与7.5之间。
在任何实施例中，方法可包含以下步骤：在流路中产生调节溶液。
在任何实施例中，产生调节溶液的步骤可包括混合碳酸氢钠溶液与酸。
在任何实施例中，产生调节溶液的步骤可包括混合碳酸氢钠溶液与二氧化碳。
在任何实施例中，调节溶液可泵送通过氧化锆模块5分钟至30分钟之间。
在任何实施例中，泵送通过氧化锆模块的调节溶液的体积可在0.5L与20L之间。
在任何实施例中，方法可包含以下步骤：通过泵送消毒剂溶液通过氧化锆吸附剂模块来给氧化锆吸附剂模块消毒。
在任何实施例中，产生调节溶液的步骤可包含在透析液流路中泵送流体通过第一吸附剂模块；第一吸附剂模块含有固体碳酸氢钠。
作为本发明的第一方面的部分公开的特征可含在本发明的第一方面中，单独地或以组合形式，或遵循所描述的元件中的一个或多个的优选配置。
本发明的第二方面被抽入系统。在任何实施例中，系统可包含：再装填流路，其具有用于收纳氧化锆模块的至少一个收纳隔室；至少一个收纳隔室具有氧化锆模块入口和氧化锆模块出口；与再装填流路流体连接的碱源；与再装填流路流体连接的碳酸氢盐源；泵，其用于将流体从碱源和碳酸氢盐源泵送通过氧化锆模块。
在任何实施例中，系统可包含与再装填流路流体连接的酸源。
在任何实施例中，系统可包含在再装填流路中的静态混合器；其中静态混合器与酸源和碳酸氢盐源流体连接。
在任何实施例中，系统可包含与再装填流路流体连接的二氧化碳源。
在任何实施例中，二氧化碳源可通过流体连接器与碳酸氢盐源流体连接。
在任何实施例中，系统可包含在流体连接器上的压力传感器。
在任何实施例中，系统可包含在再装填流路中的pH值传感器。
在任何实施例中，系统可包含在再装填流路中的至少第二收纳隔室用于收纳磷酸锆模块；第二收纳隔室具有磷酸锆模块入口和磷酸锆模块出口和连接磷酸锆模块出口与氧化锆模块入口的流体连接器。
在任何实施例中，系统可包含与磷酸锆模块入口流体连接的酸源、盐水源或其组合。
作为本发明的第二方面的部分公开的特征可含在本发明的第二方面中，单独地或以组合形式，或遵循所描述的元件中的一个或多个的优选配置。
附图说明
图1显示用于再装填并调节氧化锆模块的流路。
图2显示用于由碳酸氢盐溶液和酸溶液产生调节溶液的流路。
图3显示用于由碳酸氢盐溶液源和二氧化碳源产生调节溶液的流路。
图4显示用于由流经磷酸锆模块的碳酸氢盐溶液产生调节溶液的流路。
图5显示用于再装填磷酸锆模块以及再装填并调节氧化锆模块的流路。
图6显示用于在准备期间调节氧化锆模块的透析液流路。
图7显示用于使用固体碳酸氢盐源调节氧化锆模块的透析液流路。
图8是说明再装填并调节氧化锆模块的步骤的流程图。
图9显示用于再装填并调节氧化锆的再装填器。
图10显示连接在一起的用于再装填并调节多个氧化锆模块的多个再装填器。
具体实施方式
除非另外定义，否则所使用的所有技术和科学术语都具有与所属领域普通技术人员通常所理解的相同的含义。
冠词“一个(种)(a/an)”用于指所述冠词的一个或多于一个(即，指至少一个)语法宾语。例如，“一元件”意指一个元件或多于一个元件。
如所使用的“酸”可以是路易斯酸或布朗斯特-劳里
Figure BDA0001478890510000031
酸。路易斯酸能够接受孤对电子。布朗斯特-劳里酸能够对其它化合物供给氢离子。
“酸源”是从中可获得酸性溶液的流体或浓缩物源。
术语“碱溶液”指任何含有氢氧根离子并且pH值大于7.0的水溶液。
“碱源”是从中可获得碱性溶液的流体或浓缩物源。
术语“碳酸氢盐源”指呈固体和/或溶液形式的碳酸氢根离子源。碳酸氢根离子可以任何类型的碳酸氢盐的形式存在。碳酸氢盐源可含有至少一个流体通道，并且包含部件，如导管、阀、过滤器或流体连接接口，其中的任一者均彼此流体连接或与流体流路流体连接。碳酸氢盐源可以独立封闭体的形式或与含有碳酸氢盐源的设备一体地形成的隔室的形式形成。
“盐水源”是从中可获得盐水溶液的流体或浓缩物源。如本文中所使用，盐水溶液可以指包括酸、碱和/或盐的任何溶液。
“二氧化碳源”指含有二氧化碳气体的储存器、加压气缸或储罐。
术语“包括”包含(但不限于)在词语“包括”之后的任何事物。术语的使用表明所列要素是必需的或必选的，但其它要素是可选的并且可能存在的。
术语“调节(conditioning)”或“调节(to condition)”指设计用来在透析中安全并有效使用部件的方法。
如本文中所使用，“调节溶液”是用于调节氧化锆模块的含有碳酸氢根离子的溶液。
“连接器”和“用于连接”描述在两个部件之间形成流体连接的概念，其中流体、气体或气体与流体二者的混合物可从一个部件通过连接器或用于连接的部件流动至另一部件。连接器在其最广泛意义上提供流体连接，并且可包含本发明的任何一个或多个部件之间的任何类型的管道、流体或气体通道或导管。连接可任选地断开并且随后再连接。
术语“由……组成”包含并且限于在短语“由……组成”之后的任何事物。短语表明被限制要素是必需的或必选的，并且不可存在其它要素。
术语“主要由…组成”包含在术语“主要由…组成”之后的任何事物和不影响所描述设备、结构或方法的基本操作的其它元件、结构、动作或特征。
“控制系统”可以是一起作用来维持系统达到一系列所期望的效能规格的部件的组合。控制系统可使用配置成用于交互操作来维持所期望的效能规格的处理器、存储器及计算机部件。控制系统还可包含本领域内已知的用于维持效能规格的流体或气体控制部件和溶质控制部件。
术语“期望的氧化锆流出物pH值”指在透析期间流体流出氧化锆模块的优选pH值范围。
术语“确定(determining)”和“确定(determine)”指确认系统或变量的特定状态或期望状态。
“透析液流路”是透析期间流体将移动的路径。
术语“消毒剂溶液”指能够消灭或去除可再用吸附剂模块中的细菌污染物的任何溶液。
术语“消毒(disinfecting)”、“消毒(disinfected)”或来“消毒”指去除部件或系统中的细菌污染物。
“流路”是流体可以移动通过的一个或多个连接器或部件。
术语“流体”可以是具有非固定形状的容易受外部压力作用而形变的任何物质，如气体或液体。具体地说，流体可以是以任何浓度含有任何溶质的水。
术语“可流体连接”、“流体连接”和“用于流体连接”指将流体或气体从一个位置传递到另一位置的能力。两个位置可以处于所有任何类型的隔室、模块、系统、部件和再装填器中的任一者或多者内或之间。连接可任选地断开并且随后再连接。
“流体连接器”、“流体连接”等等描述在其中流体或气体能够由一个部件流经连接器或连接部件到达另一部件的两个部件之间的连接。连接器在其最广泛意义上提供流体连接，并且可包含本发明的任何一个或多个部件之间的任何类型的管道、流体或气体通道或导管。连接可任选地断开并且随后再连接。
术语“产生”或“来产生”指从一个或多个流体源创造具有指定浓度、pH值、温度和/或体积的流体。
术语“混合”或“来混合”通常指使来自任何源的两个或更多个流体合并在一起。例如，“混合”可包含在流体管线或接头中的位置处的湍流。“混合”的另一实例可包含在被配置成接受来自一个或多个源的流体的部件中接受一个或多个流体且在部件中将流体混合在一起。“混合”的另一实例包含用于溶解一个或多个待溶解于一个或多个流体中的固体部件的一个或多个流体。
“模块入口”是流体、浆液或水溶液可通过其进入吸附剂模块的连接器。
“模块出口”为流体、浆液或水溶液可通过其离开吸附剂模块连接器。
术语“pH值传感器”是指用于测量器皿、容器或流体管线中液体的pH值或H+浓度的装置。
术语“压力传感器”是指用于测量器皿、容器或流体管线中的气体或液体的压力的装置。
术语“泵”指通过施加吸力或压力来引起流体或气体移动的任何装置。
术语“泵送(pumping)”、“泵送(pumped)”或来“泵送”指用泵移动流体。
“再装填”是指处理吸附剂材料以恢复吸附剂材料的功能性能力，从而将吸附剂材料放回在新的透析阶段中再使用或使用的情况中。在一些情况下，“可再装填”吸附剂材料的总质量、重量和/或量保持相同。在一些情况下，“可再装填的”吸附剂材料的总质量、重量及/或量变化。在不受限于本发明的任何一个理论的情况下，再装填过程可涉及用不同离子来更换结合于吸附剂材料的离子，在一些情况下，可能增加或降低系统的总质量。然而，在一些情况下，吸附剂材料的总量将不会被再装填过程改变。当吸附剂材料正在经历“再装填”时，可随后称吸附剂材料为“经再装填的”。
“再装填流路”是当在可再用吸附剂模块中再装填吸附剂材料时流体可移动经过的路径。
“收纳隔室”是再装填器或安置待再装填的吸附剂模块的其它设备内的空间。
术语“饱和”指在给定操作条件下含有最大量的溶质的溶液。
术语“固体碳酸氢钠”指呈固相的碳酸氢钠和可包含颗粒形式、结晶形式或粉末形式或其组合的碳酸氢钠。
“吸附剂筒模块”或“吸附剂模块”意指吸附剂筒的精密部件。多个吸附剂筒模块可装配在一起形成具有两个、三个或更多个吸附剂筒模块的吸附剂筒。在一些实施例中，单一吸附剂筒模块可含有用于透析的所有所需材料。在此类情况下，吸附剂筒模块可以是“吸附剂筒”。
吸附剂“再装填器”是被设计成再装填至少一种吸附剂材料的设备。
“静态混合器”是配置成接受来自一个或多个源的流体并将流体混合一起的部件。静态混合器可包含搅拌流体以进一步混合的部件。
“氧化锆”，亦称水合氧化锆，是去除流体中的阴离子并将被去除的阴离子更换成不同阴离子的吸附剂材料。
“氧化锆吸附剂模块”是含有氧化锆的吸附剂模块。
“磷酸锆”是去除流体中的阳离子并将被去除的阳离子更换成不同阳离子的吸附剂材料。
“磷酸锆吸附剂模块”是含有磷酸锆的吸附剂模块。
氧化锆调节
本发明关注用于在再装填之后调节氧化锆吸附剂模块以再使用于透析中的系统和方法。图1说明用于再装填并调节氧化锆吸附剂模块102的再装填器流路的非限制性实施例。氧化锆吸附剂模块102可置于再装填器的收纳隔室中，并且通过氧化锆模块入口103与再装填流路101流体连接，并且通过氧化锆模块出口104与流出物管线109流体连接。含有强碱，如氢氧化钠，的碱溶液可从与再装填流路101流体连接的碱源105泵送通过氧化锆吸附剂模块102。泵107提供用于泵送流体经过再装填流路101的动力。碱溶液中的氢氧根离子将代替磷酸根和在透析期间结合于氧化锆的其它阴离子。在泵送碱溶液通过氧化锆吸附剂模块102之后，氧化锆将基本上被氢氧根离子饱和，并且处于将从溶液中消耗全部碳酸根，包含CO3 2-、HCO3 -和CO2气体，的状态。通过氧化锆消耗全部碳酸根产生具有治疗上不能接受的pH值的碱性透析液。与避免消耗全部碳酸根，必须调节氧化锆。调节过程使氧化锆吸附剂模块102处于适合用于在透析中再使用的化学状态中。用碳酸氢钠调节氧化锆使氧化锆处于具有碳酸氢盐调节溶液的pH平衡中。为在氧化锆吸附剂模块102中调节氧化锆，将预定的期望的氧化锆流出物pH值的碳酸氢盐溶液从与再装填流路101流体连接的碳酸氢盐源106泵送通过氧化锆吸附剂模块102。阀108控制流体从碱源105和碳酸氢盐源106通过再装填流路101的移动。本领域的技术人员应理解，可以包含其它或替代流体源用于再装填并调节氧化锆吸附剂模块102。可以包含含有消毒剂溶液，如漂白剂、过氧乙酸、柠檬酸或本领域中已知的任何其它消毒剂，的消毒剂源(未图示)，用于在再使用之前消毒氧化锆吸附剂模块102。可通过在再装填和调节过程的开始、在调节和再装填之后或与调节或再装填步骤中的任一者并行地泵送消毒剂溶液通过氧化锆吸附剂模块102，用漂白剂、过氧乙酸、柠檬酸或任何其它消毒剂消毒氧化锆吸附剂模块102。可通过使用组合的碱和漂白剂溶液，将氧化锆吸附剂模块102并行地消毒并再装填。或者，可通过使用期望的氧化锆流出物pH值的组合的碳酸氢盐和漂白剂溶液，将氧化锆吸附剂模块102并行地消毒并调节。可包含水源(未图示)，用于在消毒或再装填或调节之前或之后漂洗或冲洗氧化锆吸附剂模块102。
将调节溶液泵送通过氧化锆吸附剂模块102持续足够时长以确保完全调节。可将调节溶液泵送通过氧化锆吸附剂模块102持续任何时长，包含5与30分钟、5与10分钟、5与8分钟、7与10分钟、8与12分钟、10与15分钟、10与30分钟、15与25分钟或20与30分钟中的任一者之间。
透析期间，氧化锆吸附剂模块102被与磷酸锆和用于再生透析液的其它吸附剂材料一起使用。为简化治疗和治疗建模，期望达到氧化锆模块与磷酸锆的平衡。磷酸锆与氧化锆的平衡意指在治疗期间氧化锆流出物和磷酸锆流出物的pH值相同。例如，若测定期望的磷酸锆流出物pH值是6.5，则期望的氧化锆流出物pH值也可是6.5并且调节过程可使用pH值6.5的碳酸氢盐溶液来使磷酸锆和氧化锆吸附剂模块处于平衡状态。然而，可通过使用期望的氧化锆流出物pH值的碳酸氢盐溶液将氧化锆调节成任何期望的氧化锆流出物pH值。
碳酸氢盐源106中的碳酸氢盐可包含呈固体和/或溶液形式的碳酸氢根离子。例如，在碳酸氢盐源106中可包含碳酸氢盐干燥筒。可向碳酸氢盐源106添加水溶解干燥筒中的碳酸氢盐或水可流经干燥筒，产生已知浓度的碳酸氢盐溶液用于调节。或者，碳酸氢盐源106可包含预制碳酸氢盐溶液。
碳酸氢盐源106中的碳酸氢盐的浓度可以是产生期望的氧化锆流出物pH值的任何浓度。在某些实施例中，用于调节氧化锆的碳酸氢盐的浓度可在0.1M与饱和之间、0.1M与1.0M之间、0.5M与1.0M之间、0.5M与2.0M之间、1.0M与饱和之间或2.0与饱和之间。期望的氧化锆流出物pH值可以是任何pH值，并且在一优选实施例中是在5.0与7.5之间。在某些实施例中，期望的锆流出物pH值可以是5.0与6.0之间、5.0与6.5之间、5.5与6.5之间、5.5与7.0之间、6.0与7.5之间或6.5与7.5之间中的任一者。在某些实施例中，可以在调节氧化锆的同时加热调节溶液至指定温度。调节溶液可加热至20与100℃之间的任何温度，包含20与35℃之间、20与50℃之间、40与60℃之间、40与80℃之间、50与75℃之间或50与100℃之间。每克氧化锆大约4毫摩尔碳酸氢盐是具有每克氧化锆约0.8毫摩尔磷酸根的磷酸根容量的氧化锆吸附剂模块的完全调节所必需的。本领域的普通技术人员应理解，含有更多氧化锆或具有更高磷酸根容量的氧化锆模块将需要更多碳酸氢盐。例如，碳酸氢盐溶液可以是pH值6.5的1M碳酸氢盐溶液，需要1.3L调节溶液。浓度越高的情况，所需调节溶液将越少。然而，因为在pH值约6.5下大量二氧化碳气体将与碳酸氢盐平衡，所以需要高压来产生稳定的6.5pH值的高浓度的碳酸氢盐溶液。若压力不够高，将出现二氧化碳的脱气和释放。使用的碳酸氢盐调节溶液的浓度和体积可根据期望的氧化锆流出物pH值和系统的压力能力。使用的调节溶液可以任何体积，包含0.5与20.0L、0.5与1.0L、0.75与1.25L、1.0与1.5L、1.0与5.0L、2.5与7.5L、5.0与15.0L、5.0与20.0L或10.0与20.0L中的任一者之间。尽管再装填流路101被作为用于再装填并调节氧化锆吸附剂模块102的流路来说明，本领域的技术人员应理解，可构建不具有碱源105的独立调节设备仅用于调节氧化锆吸附剂模块102。
如图1中所示，可在预混合碳酸氢盐源106中以适当pH值提供期望的氧化锆流出物pH值的含有碳酸氢钠的调节溶液。或者，可由系统产生调节溶液。图2说明用于产生调节溶液的系统。氧化锆吸附剂模块202可置于再装填器或独立调节设备的收纳隔室中，并且通过氧化锆吸附剂模块入口203连接于流路201并且通过氧化锆吸附剂模块出口204连接于流出物管线209。为产生调节溶液，来自碳酸氢盐源205的碳酸氢钠可与来自酸源206的酸混合。泵207提供用于泵送流体经过流路201的动力。酸源206的酸可以是任何酸，包含乙酸、盐酸或本领域中已知的任何其它酸。可以将碳酸氢盐源205中碳酸氢盐的浓度和酸源206中酸的浓度设置为当在流路201中混合时能够产生具有期望的氧化锆流出物pH值调节流体。在流路201中可以包含静态混合器(未图示)来确保酸与碳酸氢盐的混合。或者，可以通过在两管线之间的接头处混合流体流来混合酸与碳酸氢盐。pH值传感器208确保经混合的调节溶液的pH值在期望的氧化锆流出物pH值的可接受范围内。可以包含阀(未图示)来控制来自碳酸氢盐源205和酸源206的流体移动，使得得到具有由所使用的碳酸氢盐与酸的相对量控制的可变pH值的可定制的调节溶液。本领域的技术人员应理解，在单一系统中，图2的流路201中可以包含碱源(未图示)用于在调节之前再装填氧化锆吸附剂模块202。或者，独立再装填器可以再装填氧化锆吸附剂模块202，并且用不同设备进行调节。
图3说明一个使用来自二氧化碳源306的二氧化碳气体产生调节溶液的替代方法。氧化锆吸附剂模块302可置于再装填器或调节设备的收纳隔室中，并且通过氧化锆模块入口303连接于流路301并且通过氧化锆模块出口304连接于流出物管线309。泵307提供用于移动流体经过流路301的动力。与流路301流体连接的碳酸氢盐源305可以含有具有较高pH值的碳酸氢盐溶液。来自二氧化碳源306的二氧化碳气体可以通过流体连接器计量加入碳酸氢盐源305，来产生具有期望的氧化锆流出物pH值的碳酸氢盐溶液。压力调节器308控制二氧化碳气体向碳酸氢盐源305的流动，使得控制混合之后的流体的pH值。压力传感器(未图示)确保二氧化碳的适当压力输送给碳酸氢盐源305。pH值传感器(未图示)可确保产生的溶液的pH值是期望的氧化锆流出物pH值。本领域的技术人员应理解，在单一系统中，图3的流路301中可包含碱源(未图示)用于在调节之前再装填氧化锆吸附剂模块302。或者，独立再装填器可再装填氧化锆吸附剂模块302，并且用不同设备进行调节。
图4说明具有磷酸锆吸附剂模块406的用于产生调节溶液的流路401。氧化锆吸附剂模块402可置于再装填器或调节设备的收纳隔室中，并且通过氧化锆模块入口403连接于流路401，并且通过氧化锆模块出口404连接于流出物管线410。泵407提供用于泵送流体经过流路401的动力。与流路401流体连接的碳酸氢盐源405，可以含有具有任何pH值的碳酸氢盐。第二收纳隔室可以收纳磷酸锆吸附剂模块406。碳酸氢盐溶液流经磷酸锆吸附剂模块406，磷酸锆吸附剂模块406由流体连接器通过磷酸锆模块入口409和磷酸锆模块出口408连接于流路401。碳酸氢盐调节溶液将与磷酸锆吸附剂模块406平衡，产生具有依赖于负载在磷酸锆吸附剂模块406上的氢与钠的相对量的pH值的碳酸氢盐溶液。因此，若磷酸锆吸附剂模块406是在透析中与氧化锆吸附剂模块402一起使用的同一个磷酸锆吸附剂模块，或负载的氢与钠离子的比率与用于透析中的磷酸锆吸附剂模块相同，则流出磷酸锆吸附剂模块406的调节溶液的pH值将是期望的平衡pH值。本领域的技术人员应理解，在单一系统中，图4的流路401中可包含碱源(未图示)用于在调节之前再装填氧化锆吸附剂模块402。或者，独立再装填器可再装填氧化锆吸附剂模块402，并且用不同设备进行调节。在图4中说明的磷酸锆吸附剂模块406可以是专用磷酸锆吸附剂模块，或将被从流路401中去除并且用于后续透析的磷酸锆吸附剂模块。专用磷酸锆吸附剂模块能够在被再装填或替换之前经过多个循环产生调节溶液。调节氧化锆模块需要大约150g磷酸锆。更大磷酸锆吸附剂模块可以用于多个调节循环而无需再装填。例如，含有1,500g磷酸锆的磷酸锆吸附剂模块在被替换或再装填之前可以用于大约10个调节循环。可使用任何大小的磷酸锆吸附剂模块调节氧化锆吸附剂模块。
图5说明用于再装填磷酸锆和氧化锆的再装填流路500，具有用于产生调节溶液的经再装填的磷酸锆吸附剂模块506。氧化锆吸附剂模块502可置于再装填器的收纳隔室中，并且通过氧化锆模块入口503连接于再装填流路501，并且通过氧化锆模块出口504连接于流出物管线520。泵511提供用于移动流体通过氧化锆再装填流路501的动力。可以泵送来自碱源505的碱溶液通过阀512并且通过氧化锆吸附剂模块502来再装填氧化锆。再装填器也可具有第二收纳隔室用于收纳磷酸锆吸附剂模块506，磷酸锆吸附剂模块506可通过磷酸锆模块入口507和磷酸锆模块出口508连接于磷酸锆再装填流路519。通过泵送来自盐水源509的盐水溶液通过阀514和磷酸锆吸附剂模块506来再装填磷酸锆吸附剂模块506。盐水溶液可以含有酸、碱、盐或其组合。在盐水溶液中氢和钠离子代替透析期间由磷酸锆吸附的钾、钙、镁、铵和其它阳离子。泵513提供用于移动流体通过磷酸锆再装填流路519的动力。流出磷酸锆吸附剂模块出口508的流出物可流经阀515到达排放管线517到达废物储存器516或排放口(未图示)。流出氧化锆吸附剂模块502的碱性流出物可以泵送到同一个废物储存器516、排放口(未图示)，或单独收集在独立的废物储存器(未图示)中用于后续弃置。
在再装填氧化锆吸附剂模块502和磷酸锆吸附剂模块506之后，可以调节氧化锆吸附剂模块502。可泵送来自碳酸氢盐源510的碳酸氢盐溶液通过磷酸锆吸附剂模块506，产生期望的氧化锆流出物pH值的碳酸氢盐溶液。阀515可切换成将碳酸氢盐溶液导入氧化锆再装填流路501中的流体连接器518和阀512。将碳酸氢盐溶液从阀512泵送通过氧化锆吸附剂模块502来调节氧化锆吸附剂模块502。
图1至图5说明各种调节再装填器或独立调节系统中的再装填氧化锆吸附剂模块的方法。如图6中所示，经再装填的氧化锆吸附剂模块也可在系统的准备期间在透析液流路601中调节。图6是透析液流路601的简化图。处理期间，泵送透析液经过透析液流路601和透析器605。泵604提供用于泵送流体经过透析液流路601的动力。同时，泵送血液通过半透膜606对侧的透析器605。患者血液的废物产物在透析器605中穿过半透膜606进入透析液。通过吸附剂筒609从透析液中去除废物产物，吸附剂筒609包含磷酸锆吸附剂模块603和氧化锆吸附剂模块602。本领域的技术人员应理解，吸附剂筒609中可包含其它材料，如活性碳、脲酶和氧化铝(未图示)。为将系统和吸附剂筒609准备好，泵送含有碳酸氢钠的溶液经过透析液流路601、透析器605和吸附剂筒609。在某些实施例中，溶液也可含有氯化钠。或者，方法可使用碳酸氢钠溶液后接氯化钠溶液，或氯化钠溶液后接碳酸氢钠溶液。将来自水源(未图示)的水、来自氯化钠源(未图示)的氯化钠添加至透析液流路601中，并且通过泵608将来自碳酸氢盐源607的碳酸氢钠添加至透析液流路601中。泵送所得准备溶液经过透析液流路601来准备系统。泵送含有碳酸氢盐的准备溶液通过磷酸锆吸附剂模块603，产生期望的氧化锆流出物pH值的碳酸氢盐溶液，并且随后通过氧化锆吸附剂模块602，调节氧化锆吸附剂模块602。在添加碳酸氢盐之后，准备溶液可在透析液流路601内再循环以便将碳酸氢盐的利用最大化。在某些实施例中，经过透析液流路601的流体的一个通过可在添加碳酸氢盐下进行，并且流体的第二个通过可在不添加额外碳酸氢盐下进行。
在准备期间调节氧化锆吸附剂模块602，需要在透析系统中有额外碳酸氢盐，并且延长准备所需时间。在准备期间调节所需的碳酸氢盐溶液的额外量可为约80至120g碳酸氢钠。在准备期间调节氧化锆吸附剂模块602还使准备过程延长5至15分钟之间。调节再装填器或独立调节系统中的氧化锆吸附剂模块602达成用于治疗的较小碳酸氢盐源和较快准备过程。在任何实施例中，氧化锆吸附剂模块602可部分地在再装填器或调节系统中调节并且部分地在准备期间调节，减少在系统的准备期间所需要的额外碳酸氢盐。在调节之后，过量碳酸氢钠可通过泵610冲洗进排放管线609或用于后续准备步骤。排放管线609可以流体连接于排放储存器611，或者，直接流体连接于排放口(未图示)。
图7是透析液流路701的替代简化图。处理期间，泵送透析液经过透析液流路701和透析器705。泵704提供用于泵送流体经过透析液流路701的动力。同时，泵送血液通过半透膜706对侧的透析器705。患者血液中的废物产物在透析器705中可穿过半透膜706进入透析液。通过吸附剂筒709从透析液中去除废物产物，吸附剂筒709包含磷酸锆吸附剂模块710、氧化锆吸附剂模块702和额外吸附剂模块703。额外吸附剂模块703可含有固体碳酸氢钠或粉末，可用于在透析液流路701中产生调节溶液。本领域的技术人员应理解，吸附剂筒709中可包含其它材料，如活性碳、脲酶和氧化铝(未图示)。在某些实施例中，活性碳、脲酶和氧化铝可包含在具有碳酸氢盐的吸附剂模块703中。或者，固体碳酸氢钠可如磷酸锆一样置于同一个吸附剂模块710中。为将系统和吸附剂筒709准备好，泵送含有氯化钠的溶液经过透析液流路701、透析器705和吸附剂筒709。可将来自水源(未图示)的水和任选地来自氯化钠源的氯化钠(未图示)添加到透析液流路701中。流体流经吸附剂模块703时可溶解吸附剂模块703内的碳酸氢钠来产生含有碳酸氢钠的准备和调节溶液。在某些实施例中，调节溶液也可含有氯化钠。或者，方法可产生碳酸氢钠溶液，随后氯化钠溶液。通过在吸附剂模块703中使用固体碳酸氢钠，降低了对碳酸氢盐源707的大小要求，并且减少了准备和调节时间。泵送所得准备溶液经过透析液流路701来准备系统。泵送含有由穿过吸附剂模块703的流体溶解的碳酸氢盐的准备溶液通过磷酸锆吸附剂模块710，产生期望的氧化锆流出物pH值的碳酸氢盐溶液，并且随后通过氧化锆吸附剂模块702，调节氧化锆吸附剂模块702。
用通过在吸附剂模块703中溶解固体碳酸氢钠而形成的调节溶液调节氧化锆吸附剂模块702需要一定量的碳酸氢钠首先存在于吸附剂模块703中。存在于吸附剂模块703中的碳酸氢盐的量可以是任何足以充分调节氧化锆吸附剂模块702的量。在某些实施例中，置于吸附剂模块703中的碳酸氢钠的量可在40与130克之间、40与60克之间、50与100克之间、50与130克之间、75与100克之间或80与130克之间。所需碳酸氢钠量可根据氧化锆吸附剂模块702的大小改变。在某些实施例中，超出调节氧化锆吸附剂模块702所需的过量碳酸氢钠可置于吸附剂模块703中。在调节之后，过量碳酸氢盐可通过泵712从透析液流路701中冲洗进排放管线711或用于后续准备步骤。在产生碳酸氢盐溶液之后碳酸氢盐溶液可在透析液流路701内再循环以便将碳酸氢盐在期间准备的利用最大化。排放管线711可以流体连接于排放储存器713，或者，直接流体连接于排放口(未图示)。
如所述，调节溶液的pH值可与来自后续用于透析的磷酸锆吸附剂模块的流出物的pH值相同。
图8是说明再装填并且调节氧化锆吸附剂模块达到适当pH值的步骤的流程图。在步骤801中，可测定期望的氧化锆流出物pH值。在步骤802中，用强碱再装填氧化锆吸附剂模块。在步骤803中，产生调节溶液。所描述的产生调节溶液的方法中的任一者均可用于步骤803中，包含：混合碳酸氢盐溶液与酸；混合碳酸氢盐溶液与二氧化碳；泵送碳酸氢盐溶液通过再装填器、调节系统或透析液流路任一者中的专用或非专用磷酸锆吸附剂模块；或泵送水通过透析液流路中的含有固体碳酸氢钠的吸附剂模块。在步骤804中，泵送调节溶液通过氧化锆吸附剂模块。在步骤805中，氧化锆吸附剂模块再使用于透析中。
图9说明用于在氧化锆模块中再装填并调节氧化锆的再装填器的非限制性实施例。再装填器901包含用于收纳氧化锆吸附剂模块905的氧化锆收纳隔室904。再装填器901也可具有磷酸锆收纳隔室902用于收纳磷酸锆吸附剂模块903。磷酸锆吸附剂模块903可以是专用磷酸锆吸附剂模块或将用于后续透析阶段的磷酸锆吸附剂模块。可泵送调节溶液通过磷酸锆吸附剂模块903且随后进入氧化锆吸附剂模块905用于调节。或者，调节溶液可单独地产生或储存，并且无需流经磷酸锆吸附剂模块903。门907在操作期间控制对收纳隔室902和904的进入。碱源和碳酸氢盐源(未图示)可以与用于再装填并调节氧化锆吸附剂模块905的再装填器901流体连接。流体连接(图9中未示出)连接于吸附剂模块903和905的顶部和底部，用于将再装填流体传递至、传递通过以及传递出可再用吸附剂模块903和905。也可提供盐水源(未图示)用于再装填磷酸锆吸附剂模块903。提供使用者界面906来由使用者开始或控制再装填和调节过程。使用者界面906还向使用者提供再装填和调节过程的状态，如每个步骤的完成时间，或直到过程完成为止的时间。当在再装填期间检测到任何问题，如泄漏、阻塞、泵故障或化学品不匹配时，使用者界面906还会提供警告消息。使用者界面906还允许使用者输入期望的氧化锆流出物pH值来控制调节过程。
尽管在图9中显示用于氧化锆和磷酸锆吸附剂模块的收纳隔室902和904，可类似地构建仅具有氧化锆收纳隔室的再装填器901。如所述，调节溶液可单独产生，并且无需流经磷酸锆吸附剂模块。再装填器可具有任何数目的收纳隔室用于氧化锆和磷酸锆吸附剂模块的任何组合，包含1、2、3、4、5、6、7或更多个收纳隔室用于再装填并调节任何数目的氧化锆模块。
如图10中所示，多个再装填器可连接在一起并且连接于单一一组流体源用于共享基础设施。具有磷酸锆收纳隔室1003和氧化锆收纳隔室1002的第一再装填器1001与水源1007、碳酸氢盐源1008、消毒剂源1009和碱源1010流体连接。所使用的磷酸锆模块可以是专用磷酸锆吸附剂模块或将用于后续透析的磷酸锆吸附剂模块。用于在再装填器中再装填磷酸锆和氧化锆，可包含盐水源(未图示)用于磷酸锆再装填。具有氧化锆收纳隔室1005和磷酸锆收纳隔室1006的第二再装填器1004也与相同的水源1007、碳酸氢盐源1008、消毒剂源1009和碱源1010流体连接。任何数目的再装填器可连接于一组共用流体源，包括2、3、4、5、6或更多个再装填器，每个再装填器均与单一一组流体源和单一一组废物储存器流体连接。将多个再装填器连接到单一一组流体源节省空间和材料，并且在临床或医院情境中简化再装填多组可再用模块。每个再装填器可包含独立排放管线和/或独立废物储存器，或每个再装填器可流体连接于共用排放管线。排放管线也可流体连接于排放口、共用储存器或其组合中的任一者。如所述，再装填器可替代地仅具有氧化锆收纳隔室用于仅再装填并调节氧化锆。
所属领域的技术人员应理解，可以依据操作的特定需要而在所描述的系统和方法中作出各种组合和/或修改和变化。而且，被作为本发明的一方面的部分而说明或描述的特征可用于本发明的方面中，单独地或以组合形式，或遵循所描述的元件中的一个或多个的优选配置。

Claims (19)

1.一种调节氧化锆的方法，包括以下步骤：
在流路中泵送调节溶液通过氧化锆吸附剂模块；
泵送碱溶液通过所述氧化锆吸附剂模块以在所述氧化锆吸附剂模块中再装填氧化锆；和
使用所述调节溶液调节所述氧化锆吸附剂模块，所述调节溶液包括期望的氧化锆流出物pH值的碳酸氢钠。
2.根据权利要求1所述的方法，进一步包括以下步骤：在泵送所述调节溶液通过所述氧化锆吸附剂模块之前，泵送所述调节溶液通过磷酸锆吸附剂模块。
3.根据权利要求2所述的方法，其中所述流路是包括所述磷酸锆吸附剂模块和所述氧化锆吸附剂模块的透析液流路。
4.根据权利要求2所述的方法，其中所述流路是包括所述磷酸锆吸附剂模块和所述氧化锆吸附剂模块的再装填流路。
5.根据权利要求1所述的方法，其中所述期望的氧化锆流出物pH值在5与7.5之间。
6.根据权利要求1所述的方法，进一步包括在所述流路中产生所述调节溶液的步骤。
7.根据权利要求6所述的方法，其中产生所述调节溶液的所述步骤包括混合碳酸氢钠溶液与酸。
8.根据权利要求6所述的方法，其中产生所述调节溶液的所述步骤包括混合碳酸氢钠溶液与二氧化碳。
9.根据权利要求1所述的方法，其中泵送所述调节溶液通过所述氧化锆吸附剂模块持续5至30分钟之间。
10.根据权利要求1所述的方法，进一步包括以下步骤：通过泵送消毒剂溶液通过所述氧化锆吸附剂模块来消毒所述氧化锆吸附剂模块。
11.根据权利要求6所述的方法，其中产生所述调节溶液的所述步骤包括在透析液流路中泵送流体通过第一吸附剂模块；所述第一吸附剂模块含有固体碳酸氢钠。
12.一种系统，包括：
再装填流路，包括用于收纳氧化锆吸附剂模块的至少一个收纳隔室；所述至少一个收纳隔室包括氧化锆模块入口和氧化锆模块出口；
与所述再装填流路流体连接的碱源；
与所述再装填流路流体连接的碳酸氢盐源；
泵，用于将流体从所述碱源和所述碳酸氢盐源泵送通过所述氧化锆吸附剂模块。
13.根据权利要求12所述的系统，进一步包括与所述再装填流路流体连接的酸源。
14.根据权利要求13所述的系统，进一步包括在所述再装填流路中的静态混合器；其中所述静态混合器与所述酸源和所述碳酸氢盐源流体连接。
15.根据权利要求12所述的系统，进一步包括通过流体连接器与所述再装填流路流体连接的二氧化碳源。
16.根据权利要求15所述的系统，进一步包括在所述流体连接器上的压力传感器。
17.根据权利要求12所述的系统，进一步包括在所述再装填流路中的pH值传感器。
18.根据权利要求12所述的系统，进一步包括在所述再装填流路中的至少第二收纳隔室，用于收纳磷酸锆吸附剂模块；所述第二收纳隔室包括磷酸锆模块入口和磷酸锆模块出口；和
连接磷酸锆模块出口与所述氧化锆模块入口的流体连接器。
19.根据权利要求18所述的系统，进一步包括与所述磷酸锆模块入口流体连接的酸源、盐水源、或其组合。
CN201711179516.7A 2016-11-29 2017-11-23 氧化锆模块调节 Active CN108159733B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662427806P 2016-11-29 2016-11-29
US62/427,806 2016-11-29
US15/798,233 US10981148B2 (en) 2016-11-29 2017-10-30 Zirconium oxide module conditioning
US15/798,233 2017-10-30

Publications (2)

Publication Number Publication Date
CN108159733A CN108159733A (zh) 2018-06-15
CN108159733B true CN108159733B (zh) 2020-08-07

Family

ID=60673086

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201711179516.7A Active CN108159733B (zh) 2016-11-29 2017-11-23 氧化锆模块调节

Country Status (4)

Country Link
US (2) US10981148B2 (zh)
EP (1) EP3326668B1 (zh)
CN (1) CN108159733B (zh)
CA (1) CA2986121A1 (zh)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10981148B2 (en) * 2016-11-29 2021-04-20 Medtronic, Inc. Zirconium oxide module conditioning
US20200054807A1 (en) * 2018-08-14 2020-02-20 Medtronic, Inc. Precision dialysis therapy based on sorbent effluent analysis
US11090421B2 (en) * 2018-11-28 2021-08-17 Baxter International Inc. Systems and methods for batch sorbent material reuse
US11331597B2 (en) 2019-08-05 2022-05-17 Fresenius Medical Care Holdings, Inc. Cation exchange materials for dialysis systems

Family Cites Families (414)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1617288A (en) 1925-03-16 1927-02-08 Zeolite Engineering Co Method of and apparatus for reconditioning zeolite water softeners
US2703313A (en) 1950-01-09 1955-03-01 Aerojet General Co Cation exchange apparatus
GB1189458A (en) 1967-09-27 1970-04-29 Nat Res Dev Improvements in or relating to dialysers
US3669878A (en) 1968-12-02 1972-06-13 Health Education And Welfare U Treatment of dialysate solution for removal of urea
FR2036413A5 (zh) 1969-03-13 1970-12-24 Thomson Csf
US3669880A (en) 1969-06-30 1972-06-13 Cci Aerospace Corp Recirculation dialysate system for use with an artificial kidney machine
US3776819A (en) 1969-12-22 1973-12-04 Monsanto Co Urea determination and electrode therefor
US3617558A (en) 1970-11-02 1971-11-02 Illinois Water Treatment Co Layered ion exchange process
DE2239254C2 (de) 1970-12-30 1983-08-04 Organon Teknika Corp., Oklahoma City, Okla. "Säule zur Regenerierung einer zirkulierenden Dialysatlösung und Verwendung dieser Säule".
US3850835A (en) 1971-11-08 1974-11-26 Cci Life Systems Inc Method of making granular zirconium hydrous oxide ion exchangers, such as zirconium phosphate and hydrous zirconium oxide, particularly for column use
US3884808A (en) 1973-06-20 1975-05-20 Res Dev Systems Inc Wearable, self-regenerating dialysis appliance
US4192748A (en) 1973-07-05 1980-03-11 Hyden Viktor H Dialysis apparatus with selective chemical activity
SE373752B (zh) 1973-07-05 1975-02-17 V H Hyden
US3840835A (en) 1973-09-04 1974-10-08 Chase Shawmut Co Electric current-limiting low voltage fuse
US3902490A (en) 1974-03-27 1975-09-02 Univ Utah Portable artificial kidney system
JPS5155193A (zh) 1974-11-07 1976-05-14 Kanebo Ltd
JPS51131393A (en) 1975-05-09 1976-11-15 Hitachi Ltd High pressure choromatography and its device
US4073725A (en) 1975-05-09 1978-02-14 Hitachi, Ltd. Method and apparatus for liquid chromatography under elevated pressure
US4060485A (en) 1975-06-09 1977-11-29 I T L Technology, Inc. Dialysis apparatus
US4142845A (en) 1976-02-20 1979-03-06 Lepp William A Dialysis pump system having over-center cam tracks to lock rollers against tubing
US4094775A (en) 1977-02-28 1978-06-13 California Institute Of Technology Dialysis system
US4581141A (en) 1978-02-27 1986-04-08 Purdue Research Foundation Dialysis material and method for removing uremic substances
IT1174707B (it) 1978-05-03 1987-07-01 Bonomini Vittorio Rene artificiale portatile per dialisi
US4209392A (en) 1978-05-15 1980-06-24 Wallace Richard A Portable hepatic-assist method and apparatus for same
US4206054A (en) 1978-10-27 1980-06-03 Leon Moore Pyramidic aquarium filter-aerator
US4376707A (en) 1979-05-21 1983-03-15 Gambro Dialysatoren G.M.B.H. & Co. K.G. Process for the removal of urea from blood wash fluids and blood
US4556063A (en) 1980-10-07 1985-12-03 Medtronic, Inc. Telemetry system for a medical device
US4374382A (en) 1981-01-16 1983-02-15 Medtronic, Inc. Marker channel telemetry system for a medical device
DE3110128A1 (de) 1981-03-16 1982-09-23 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V., 8000 München Verfahren und vorrichtung zur entgiftung und regeneration von blut, blutbestandteilen und bei der blutreinigung anfallenden loesungen sowie kit fuer die durchfuehrung des verfahrens
US4381999A (en) 1981-04-28 1983-05-03 Cobe Laboratories, Inc. Automatic ultrafiltration control system
US4371385A (en) 1981-04-28 1983-02-01 Cobe Laboratories, Inc. Deaerating liquid
US4750494A (en) 1981-05-12 1988-06-14 Medtronic, Inc. Automatic implantable fibrillation preventer
US4612122A (en) 1981-06-29 1986-09-16 Clara Ambrus Removing heavy metal ions from blood
US4460555A (en) 1983-08-25 1984-07-17 Organon Teknika Corporation Ammonia scavenger
US4650587A (en) 1982-09-09 1987-03-17 Akzona Incorporated Ammonia scavenger
US4562751A (en) 1984-01-06 1986-01-07 Nason Clyde K Solenoid drive apparatus for an external infusion pump
US4685903A (en) 1984-01-06 1987-08-11 Pacesetter Infusion, Ltd. External infusion pump apparatus
US4678408A (en) 1984-01-06 1987-07-07 Pacesetter Infusion, Ltd. Solenoid drive apparatus for an external infusion pump
US4765907A (en) 1984-03-28 1988-08-23 Research Development Systems, Inc. Wearable, continuously internally operable and externally regenerable dialysis device
US4661246A (en) 1984-10-01 1987-04-28 Ash Medical Systems, Inc. Dialysis instrument with dialysate side pump for moving body fluids
FR2574664B1 (fr) 1984-12-14 1987-03-06 Issautier Gerald Dispositif d'hemodialyse permettant de controler automatiquement la perte de poids
JPS61164562A (ja) 1985-01-16 1986-07-25 鐘淵化学工業株式会社 体液成分処理装置及び体液成分処理方法
IT1191613B (it) 1985-05-15 1988-03-23 Eniricerche Spa Fosfato di zirconio e suo metodo di preparazione
US4687582A (en) 1985-12-23 1987-08-18 Dixon Walter O Method and apparatus for operating and regenerating ion exchangers
DE3634763A1 (de) 1986-10-11 1988-04-28 Josef Magasi Vorrichtung und verfahren zur blutreinigung
EP0266795B2 (en) 1986-11-07 1996-03-27 Asahi Kasei Kogyo Kabushiki Kaisha Improved regenerated cellulose membrane and process for preparation thereof
US4828693A (en) 1987-09-22 1989-05-09 Baxter Travenol Laboratories, Inc. Water pressure regulator for hemodialysis apparatus
GB8722854D0 (en) 1987-09-29 1987-11-04 Hardy S M Implantable artificial kidney
CA1327838C (fr) 1988-06-13 1994-03-15 Fred Zacouto Dispositif implantable de protection contre les affections liees a la coagulation sanguine
DE3912405C1 (zh) 1989-04-15 1990-10-31 B. Braun Melsungen Ag, 3508 Melsungen, De
US5032615A (en) 1989-10-31 1991-07-16 The Regents Of The University Of California Continuous hemodialysis using citrate
US5477864A (en) 1989-12-21 1995-12-26 Smith & Nephew Richards, Inc. Cardiovascular guidewire of enhanced biocompatibility
US5127404A (en) 1990-01-22 1992-07-07 Medtronic, Inc. Telemetry format for implanted medical device
US5097122A (en) 1990-04-16 1992-03-17 Pacesetter Infusion, Ltd. Medication infusion system having optical motion sensor to detect drive mechanism malfunction
US5080653A (en) 1990-04-16 1992-01-14 Pacesetter Infusion, Ltd. Infusion pump with dual position syringe locator
JPH0490963A (ja) 1990-08-06 1992-03-24 Toshiba Corp 操舵台車
JP2981573B2 (ja) 1990-12-12 1999-11-22 富田製薬株式会社 リン酸イオン吸着剤
US5230702A (en) 1991-01-16 1993-07-27 Paradigm Biotechnologies Partnership Hemodialysis method
US5486286A (en) 1991-04-19 1996-01-23 Althin Medical, Inc. Apparatus for performing a self-test of kidney dialysis membrane
FR2680976B1 (fr) 1991-09-10 1998-12-31 Hospal Ind Rein artificiel muni de moyens de determination caracteristiques du sang et procede de determination correspondant.
JPH0599464A (ja) 1991-10-08 1993-04-20 Nec Corp エアシヤワー装置
US5192132A (en) 1991-12-12 1993-03-09 Mobil Oil Corporation Temperature monitoring of a fixed-bed catalytic reactor
FR2687307B1 (fr) 1992-02-14 1999-06-04 Lascombes Jean Jacques Dispositif pour la preparation d'une solution a usage medical.
FR2693110B1 (fr) 1992-07-06 1994-08-19 Hospal Ind Procédé de vérification du fonctionnement de capteurs situés sur un circuit de liquide de dialyse et dispositif en faisant application.
EP0847768B1 (en) 1992-10-13 2001-09-19 Baxter International Inc. Hemodialysis monitoring system for hemodialysis machines
CA2124808A1 (en) 1992-10-13 1994-04-28 Vernon H. Troutner Fluid sampling module
US5849179A (en) 1992-10-13 1998-12-15 Baxter International Inc. Automatic apparatus for obtaining equilibration samples of dialysate
US5284470A (en) 1992-11-02 1994-02-08 Beltz Alex D Wearable, portable, light-weight artificial kidney
US5441049A (en) 1992-12-28 1995-08-15 Automata Medical Instrumentation, Inc. Conductivity meter
US5445610A (en) 1993-01-15 1995-08-29 University Of Cincinnati Portable peritoneal dialysis cycler
IT1260614B (it) 1993-03-01 1996-04-22 Sorin Biomedica Spa Procedimento per misurare la concentrazione di una sostanza in un fluido, relativo sistema ed impiego
US5302288A (en) 1993-03-19 1994-04-12 Zimpro Environmental, Inc. Treatment of highly colored wastewaters
DE4321927C2 (de) 1993-07-01 1998-07-09 Sartorius Gmbh Filtereinheit mit Entgasungsvorrichtung
US5308315A (en) 1993-07-27 1994-05-03 Raja N. Khuri Method for determining the adequacy of dialysis
US5685988A (en) 1993-09-15 1997-11-11 Malchesky; Paul Dialysis process and system
US5507723A (en) 1994-05-24 1996-04-16 Baxter International, Inc. Method and system for optimizing dialysis clearance
EP1182264B1 (en) 1994-07-29 2006-03-01 Gambro Lundia AB Method and device for measuring the concentration of a substance in a solution
US6572769B2 (en) 1994-09-26 2003-06-03 Rajan G. Rajan Water treatment apparatus
US5591344A (en) 1995-02-13 1997-01-07 Aksys, Ltd. Hot water disinfection of dialysis machines, including the extracorporeal circuit thereof
US5685835A (en) * 1995-06-07 1997-11-11 Cobe Laboratories, Inc. Technique for using a dialysis machine to disinfect a blood tubing set
SE504633C2 (sv) 1995-07-03 1997-03-24 Althin Madical Ab Anordning vid dialysmaskin
IT1276468B1 (it) 1995-07-04 1997-10-31 Hospal Dasco Spa Metodo e apparecchiatura di dialisi automatica
US5944684A (en) 1995-08-31 1999-08-31 The Regents Of The University Of California Wearable peritoneum-based system for continuous renal function replacement and other biomedical applications
US5938634A (en) 1995-09-08 1999-08-17 Baxter International Inc. Peritoneal dialysis system with variable pressure drive
US6363279B1 (en) 1996-01-08 2002-03-26 Impulse Dynamics N.V. Electrical muscle controller
US5683432A (en) 1996-01-11 1997-11-04 Medtronic, Inc. Adaptive, performance-optimizing communication system for communicating with an implanted medical device
US20090012864A1 (en) 2007-07-02 2009-01-08 Goldberg Sheldon F Compensation model for network services
US5770086A (en) 1996-01-25 1998-06-23 Eureka| Science Corp. Methods and apparatus using hydrogels
WO1997049279A1 (en) 1996-06-24 1997-12-31 Board Of Regents, The University Of Texas System Automated closed recirculating aquaculture filtration system
US6048732A (en) 1996-10-16 2000-04-11 Board Of Regents, The University Of Texas System Receptor and method for citrate determination
IT1288767B1 (it) 1996-10-18 1998-09-24 Hospal Dasco Spa Metodo di determinazione del valore del ricircolo di una sospensione sottoposta a trattamento.
US5858186A (en) 1996-12-20 1999-01-12 The Regents Of The University Of California Urea biosensor for hemodialysis monitoring
US20010009756A1 (en) 1998-01-06 2001-07-26 Derek Hei Flow devices for the reduction of compounds from biological compositions and methods of use
US5931801A (en) 1997-01-21 1999-08-03 Vasca, Inc. Valve port assembly with interlock
US6852090B2 (en) 1997-02-14 2005-02-08 Nxstage Medical, Inc. Fluid processing systems and methods using extracorporeal fluid flow panels oriented within a cartridge
SE513034C2 (sv) 1997-06-02 2000-06-19 Gambro Lundia Ab Metod och anordning för beräkning av dialyseffektivitet
EP1927370B1 (de) 1997-08-13 2013-10-02 Fresenius Medical Care Deutschland GmbH Verfahren zur Bestimmung von Parametern der Hämodialyse und Blutbehandlungsvorrichtung mit einer Einrichtung zur Bestimmung von Parametern der Hämodialyse
SE9703600D0 (sv) 1997-10-02 1997-10-02 Pacesetter Ab Heart stimulator
US6390969B1 (en) 1997-10-09 2002-05-21 Orqis Medical Corporation Implantable heart assist system and method of applying same
US6088608A (en) 1997-10-20 2000-07-11 Alfred E. Mann Foundation Electrochemical sensor and integrity tests therefor
SE9703958D0 (sv) 1997-10-29 1997-10-29 Pacesetter Ab Method and device for determination of concentration
US6648845B1 (en) 1998-01-07 2003-11-18 Fresenius Medical Care North America Method and apparatus for determining hemodialysis parameters
SE520638C2 (sv) 1998-01-21 2003-08-05 Gambro Lundia Ab Säkerhetsanordning vid dialysmaskin
SE9800407D0 (sv) 1998-02-12 1998-02-12 Pacesetter Ab Heart stimulator
US6197197B1 (en) 1998-04-23 2001-03-06 Dialysis Systems, Inc. Method for fluid delivery in a dialysis clinic
US6058331A (en) 1998-04-27 2000-05-02 Medtronic, Inc. Apparatus and method for treating peripheral vascular disease and organ ischemia by electrical stimulation with closed loop feedback control
US6358422B1 (en) 1998-05-14 2002-03-19 Amcol International Corporation Method and apparatus for removing oil from water including monitoring of absorbent saturation
SE525639C2 (sv) 1998-06-04 2005-03-22 Thore Falkvall Bestämning av slaggprodukter i dialysvätska med hjälp av optisk sensor
US6177049B1 (en) 1998-06-10 2001-01-23 Dsu Medical Corporation Reversing flow blood processing system
US6554798B1 (en) 1998-08-18 2003-04-29 Medtronic Minimed, Inc. External infusion device with remote programming, bolus estimator and/or vibration alarm capabilities
US6593747B2 (en) 1998-10-05 2003-07-15 The University Of Western Ontario Method and apparatus for monitoring adsorbent activity in situ
DK1716884T3 (en) 1998-10-29 2014-03-10 Medtronic Minimed Inc reservoir Connection
US6248093B1 (en) 1998-10-29 2001-06-19 Minimed Inc. Compact pump drive system
US7077819B1 (en) 1998-12-24 2006-07-18 Fresenius Medical Care Deutschland Gmbh Method for determining the distribution volume of a blood component during an extracorporeal blood treatment and device for carrying out the method
GB9828696D0 (en) 1998-12-29 1999-02-17 Houston J G Blood-flow tubing
US6254567B1 (en) 1999-02-26 2001-07-03 Nxstage Medical, Inc. Flow-through peritoneal dialysis systems and methods with on-line dialysis solution regeneration
US6274103B1 (en) 1999-03-26 2001-08-14 Prismedical Corporation Apparatus and method for preparation of a peritoneal dialysis solution
US6230059B1 (en) 1999-03-17 2001-05-08 Medtronic, Inc. Implantable monitor
SE9901165D0 (sv) 1999-03-30 1999-03-30 Gambro Lundia Ab Method, apparatus and components of dialysis systems
AU766427B2 (en) 1999-04-30 2003-10-16 Children's Hospital Medical Center Hemofiltration system and method baded on monitored patient parameters, supervisory control of hemofiltration, and adaptive control of pumps for hemofiltration
IL130882A0 (en) * 1999-07-11 2001-01-28 Solmecs Israel Ltd Sorbent composition
EP1072282A1 (en) 1999-07-19 2001-01-31 EndoArt S.A. Flow control device
US6491993B1 (en) 1999-08-12 2002-12-10 Pactiv Corporation Absorbent pouches
DE19938691A1 (de) 1999-08-14 2001-02-15 Volkswagen Ag Verfahren zur verkehrsgeführten Beeinflussung und/oder Unterstützung von Kraftfahrzeugen
US6272377B1 (en) 1999-10-01 2001-08-07 Cardiac Pacemakers, Inc. Cardiac rhythm management system with arrhythmia prediction and prevention
WO2001051117A1 (en) 2000-01-11 2001-07-19 Blatter Duane D Vascular occlusal balloons and related vascular access devices and systems
US6602399B1 (en) 2000-03-22 2003-08-05 Max-Planck-Gesellschaft Zur Forderung Der Wissenchaften E.V. Signal recording of a receptor-effector-system by an extracellular planar potential-sensitive electrode
US20010041869A1 (en) 2000-03-23 2001-11-15 Causey James D. Control tabs for infusion devices and methods of using the same
IL136079A0 (en) 2000-04-19 2001-05-20 Cheetah Medical Inc C O Pepper Method and apparatus for monitoring the cardiovascular condition, particularly the degree of arteriosclerosis in individuals
AU2001259469A1 (en) 2000-05-05 2001-11-20 Hemocleanse, Inc. Use of magnetic particles or other particles having relatively high density in afluid for mixing and/or leak detection
US6890315B1 (en) 2000-05-23 2005-05-10 Chf Solutions, Inc. Method and apparatus for vein fluid removal in heart failure
US6589229B1 (en) 2000-07-31 2003-07-08 Becton, Dickinson And Company Wearable, self-contained drug infusion device
US6585675B1 (en) 2000-11-02 2003-07-01 Chf Solutions, Inc. Method and apparatus for blood withdrawal and infusion using a pressure controller
US6627164B1 (en) 2000-11-28 2003-09-30 Renal Solutions, Inc. Sodium zirconium carbonate and zirconium basic carbonate and methods of making the same
US7033498B2 (en) 2000-11-28 2006-04-25 Renal Solutions, Inc. Cartridges useful in cleaning dialysis solutions
ES2256164T7 (es) 2000-12-12 2010-03-31 Jurag Separation A/S Un metodo y aparato para el aislamiento de especies ionicas a partir de un liquido.
US7788038B2 (en) 2000-12-27 2010-08-31 Koninklijke Philips Electronics N.V. Biological information and blood treating device information control system, biological information and blood treating device information control device, and biological information and blood treating device information control method
US6579460B1 (en) 2001-03-13 2003-06-17 Uop Llc Process and composition for removing toxins from bodily fluids
US6773412B2 (en) 2001-04-13 2004-08-10 Chf Solutions, Inc. User interface for blood treatment device
US7241272B2 (en) 2001-11-13 2007-07-10 Baxter International Inc. Method and composition for removing uremic toxins in dialysis processes
US6960179B2 (en) 2001-11-16 2005-11-01 National Quality Care, Inc Wearable continuous renal replacement therapy device
US7309323B2 (en) 2001-11-16 2007-12-18 National Quality Care, Inc. Wearable continuous renal replacement therapy device
US20060241543A1 (en) 2001-11-16 2006-10-26 National Quality Care, Inc. Method for installing and servicing a wearable continuous renal replacement therapy device
SE525132C2 (sv) 2001-11-23 2004-12-07 Gambro Lundia Ab Metod vid manövrering av dialysanordning
US6878283B2 (en) 2001-11-28 2005-04-12 Renal Solutions, Inc. Filter cartridge assemblies and methods for filtering fluids
US20030114787A1 (en) 2001-12-13 2003-06-19 Victor Gura Wearable peritoneal dialysis system
US20030113931A1 (en) 2001-12-14 2003-06-19 Li Pan Ammonia and ammonium sensors
US6695807B2 (en) 2002-01-18 2004-02-24 Dsu Medical, Inc. Blood flow reversing system
US6878258B2 (en) 2002-02-11 2005-04-12 Applied Materials, Inc. Apparatus and method for removing contaminants from semiconductor copper electroplating baths
US6711439B1 (en) 2002-02-14 2004-03-23 Pacesetter, Inc. Evoked response variability as an indicator of autonomic tone and surrogate for patient condition
JP3820163B2 (ja) 2002-02-22 2006-09-13 三井化学株式会社 尿素濃度測定方法および装置
US7076299B2 (en) 2002-03-28 2006-07-11 Tran Thong Method and apparatus for preventing heart tachyarrhythmia
US6878285B2 (en) 2002-04-17 2005-04-12 Watervisions International, Inc. Ion-exchange based fluid treatment systems
US7153286B2 (en) 2002-05-24 2006-12-26 Baxter International Inc. Automated dialysis system
AU2003274901A1 (en) 2002-07-19 2004-02-09 Baxter Healthcare S.A. Systems and methods for performing peritoneal dialysis
DE60336724D1 (de) 2002-07-19 2011-05-26 Baxter Healthcare Sa System für die peritonealdialyse
EP2298377A1 (en) 2002-07-19 2011-03-23 Baxter International Inc. Systems and methods for peritoneal dialysis
DE60204883T3 (de) 2002-09-05 2013-10-24 Gambro Lundia Ab Steuerung für eine Blutbehandlungsvorrichtung
US6945640B2 (en) 2002-09-11 2005-09-20 Inke Pte. Ltd. Refill station
US7144384B2 (en) 2002-09-30 2006-12-05 Insulet Corporation Dispenser components and methods for patient infusion device
US7128727B2 (en) 2002-09-30 2006-10-31 Flaherty J Christopher Components and methods for patient infusion device
WO2004039436A1 (en) 2002-10-30 2004-05-13 Gambro Lundia Ab A method and an apparatus for determining the efficiency of dialysis
US20040099593A1 (en) 2002-11-25 2004-05-27 Potito De Paolis Concurrent dialysate purification cartridge
US7060190B2 (en) 2003-02-27 2006-06-13 King Technology Dual dispenser
US20040127648A1 (en) * 2002-12-31 2004-07-01 Ciphergen Biosystems, Inc. Sorbent and method for the separation of plasmid DNA
EP1592494B1 (en) 2003-01-07 2009-06-24 NxStage Medical, Inc. Batch filtration system for preparation of sterile replacement fluid for renal therapy
US7686778B2 (en) 2003-01-15 2010-03-30 Nxstage Medical, Inc. Waste balancing for extracorporeal blood treatment systems
US7276042B2 (en) 2003-01-23 2007-10-02 National Quality Care, Inc. Low hydraulic resistance cartridge
US6861473B2 (en) 2003-02-28 2005-03-01 Baxter International Inc. Macromolecular ketoaldehydes
US7326576B2 (en) 2003-04-09 2008-02-05 Prescient Medical, Inc. Raman spectroscopic monitoring of hemodialysis
DE10317024A1 (de) 2003-04-11 2004-11-11 Fresenius Medical Care Deutschland Gmbh Blutbehandlungsvorrichtung
US7330750B2 (en) 2003-04-25 2008-02-12 Instrumentarium Corp. Estimation of cardiac death risk
WO2004105589A2 (en) 2003-05-28 2004-12-09 Hemocleanse Technologies, Llc Sorbent reactor for extracorporeal blood treatment systems, peritoneal dialysis systems, and other body fluid treatment systems
EP1506809A1 (en) 2003-08-11 2005-02-16 Boehringer Ingelheim Pharma GmbH & Co. KG Regeneration of hydrolysis sensitive adsorbent matrices
US7920906B2 (en) 2005-03-10 2011-04-05 Dexcom, Inc. System and methods for processing analyte sensor data for sensor calibration
US8026729B2 (en) 2003-09-16 2011-09-27 Cardiomems, Inc. System and apparatus for in-vivo assessment of relative position of an implant
US20050065760A1 (en) 2003-09-23 2005-03-24 Robert Murtfeldt Method for advising patients concerning doses of insulin
US7029456B2 (en) 2003-10-15 2006-04-18 Baxter International Inc. Medical fluid therapy flow balancing and synchronization system
MX351817B (es) 2003-10-28 2017-10-30 Baxter Healthcare Sa Metodos mejorados de cebado, integridad y altura sobre la cabeza y aparatos para sistemas de fluidos medicinales.
WO2005042059A2 (en) 2003-10-31 2005-05-12 Gambro Lundia Ab A circuit for extracorporeal blood treatment and flow-inverting device utilized therein
US8029454B2 (en) 2003-11-05 2011-10-04 Baxter International Inc. High convection home hemodialysis/hemofiltration and sorbent system
US7776006B2 (en) 2003-11-05 2010-08-17 Baxter International Inc. Medical fluid pumping system having real time volume determination
FR2862204B1 (fr) 2003-11-13 2006-02-10 Yves Vincent Brottier Appareil d'epilation par decharges electriques dans une lampe flash regulee en courant
EP1691862A1 (en) 2003-11-20 2006-08-23 Gambro Lundia AB Method, apparatus and software program for measurement of a parameter relating to a heart-lung system of a mammal.
US7744553B2 (en) 2003-12-16 2010-06-29 Baxter International Inc. Medical fluid therapy flow control systems and methods
CN1897993B (zh) 2003-12-24 2012-02-08 凯米卡技术有限公司 用于便携式人类透析的透析液再生系统
DE102004013814A1 (de) 2004-03-20 2005-10-13 B. Braun Medizintechnologie Gmbh Verfahren zur Gestattung von Bedienereingaben an einem medizinischen Gerät
US20050234354A1 (en) 2004-04-15 2005-10-20 Rowlandson G I System and method for assessing a patient's risk of sudden cardiac death
US7303540B2 (en) 2004-04-26 2007-12-04 Chf Solutions, Inc. User interface for blood treatment device
JP4653170B2 (ja) 2004-06-09 2011-03-16 リナル・ソリューションズ・インコーポレーテッド 透析システム
ITMO20040191A1 (it) 2004-07-23 2004-10-23 Gambro Lundia Ab Macchina e metodo per il trattamento extracorporeo di sangue.
US7356366B2 (en) 2004-08-02 2008-04-08 Cardiac Pacemakers, Inc. Device for monitoring fluid status
US7219596B2 (en) 2004-08-19 2007-05-22 Carrier Commerical Refrigeration, Inc. Coffee brewer with loading and ejection mechanism for a coffee cartridge
JP4868772B2 (ja) 2004-08-24 2012-02-01 日機装株式会社 血液浄化装置
US7615028B2 (en) 2004-12-03 2009-11-10 Chf Solutions Inc. Extracorporeal blood treatment and system having reversible blood pumps
CA2593525C (en) 2004-12-28 2011-05-10 Renal Solutions, Inc. Method of synthesizing zirconium phosphate particles
US7756572B1 (en) 2005-01-25 2010-07-13 Pacesetter, Inc. System and method for efficiently distinguishing among cardiac ischemia, hypoglycemia and hyperglycemia using an implantable medical device and an external system
WO2006086490A1 (en) 2005-02-07 2006-08-17 Medtronic, Inc. Ion imbalance detector
US20060189926A1 (en) 2005-02-14 2006-08-24 Hall W D Apparatus and methods for analyzing body fluid samples
US20060195064A1 (en) 2005-02-28 2006-08-31 Fresenius Medical Care Holdings, Inc. Portable apparatus for peritoneal dialysis therapy
JP4726045B2 (ja) 2005-04-08 2011-07-20 日機装株式会社 血液透析装置
EP2783712B1 (en) 2005-05-06 2018-07-25 Quanta Dialysis Technologies Limited Dialysis machine
US7641649B2 (en) 2005-05-06 2010-01-05 Medtronic Minimed, Inc. Reservoir support and method for infusion device
ATE479843T1 (de) 2005-05-18 2010-09-15 Gambro Lundia Ab Vorrichtung zur steuerung des blutflusses in einem extrakorporalen kreislauf
CN101180089B (zh) 2005-05-23 2010-12-08 旭化成可乐丽医疗株式会社 体液处理过滤装置
JP2007044602A (ja) 2005-08-09 2007-02-22 Kanto Chem Co Inc 触媒担体、金属固定化触媒、その製造方法およびそれを用いたアルコールの酸化方法
US7674231B2 (en) 2005-08-22 2010-03-09 Massachusetts Institute Of Technology Wearable pulse wave velocity blood pressure sensor and methods of calibration thereof
US8372025B2 (en) 2005-09-22 2013-02-12 Baxter International Inc. Automation and optimization of CRRT treatment using regional citrate anticoagulation
CN101291696B (zh) 2005-10-18 2012-11-21 株式会社Jms 腹膜功能检查装置
US20100137693A1 (en) 2005-11-01 2010-06-03 Fresenius Medical Care Holdings, Inc. Methods and systems for patient care
DE102005060866B4 (de) 2005-12-20 2009-01-15 Bruker Biospin Gmbh Kombinierte Titrations- und pH-Elektrode für die Präparation von flüssigen Messproben insbesondere für die NMR-Spektroskopie
JP2009521579A (ja) 2005-12-22 2009-06-04 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー 無機充填剤を含有する化学安定化イオノマーを製造する方法
RU2426561C2 (ru) 2006-01-30 2011-08-20 Дзе Риджентс Оф Дзе Юниверсити Оф Калифорния Способы и устройство для перитонеального диализа
US8246563B2 (en) 2006-02-02 2012-08-21 Cardiac Pacemakers, Inc. Cardiac rhythm management device and sensor-suite for the optimal control of ultrafiltration and renal replacement therapies
US8211048B2 (en) 2006-02-22 2012-07-03 Henry Ford Health System System and method for delivery of regional citrate anticoagulation to extracorporeal blood circuits
US8012118B2 (en) 2006-03-08 2011-09-06 Fresenius Medical Care Holdings, Inc. Artificial kidney dialysis system
US8715221B2 (en) 2006-03-08 2014-05-06 Fresenius Medical Care Holdings, Inc. Wearable kidney
US7785463B2 (en) 2006-03-17 2010-08-31 Children's Hospital Medical Center Extracorporeal renal replacement modeling system
US20070243113A1 (en) 2006-04-12 2007-10-18 Dileo Anthony Filter with memory, communication and concentration sensor
US8366316B2 (en) 2006-04-14 2013-02-05 Deka Products Limited Partnership Sensor apparatus systems, devices and methods
US20080058697A1 (en) 2006-04-14 2008-03-06 Deka Products Limited Partnership Heat exchange systems, devices and methods
US20070255125A1 (en) 2006-04-28 2007-11-01 Moberg Sheldon B Monitor devices for networked fluid infusion systems
US8226595B2 (en) 2006-05-26 2012-07-24 Baxter International Inc. Automated dialysis system driven by gravity and vacuum
US7572232B2 (en) 2006-07-24 2009-08-11 Cardiac Pacemakers, Inc. Cardiac signal display and event detection using multiresolution Z-score transform
SE532971C2 (sv) 2006-08-16 2010-05-25 Triomed Ab System för regenerering av en vätska
US7887502B2 (en) 2006-09-15 2011-02-15 University Of Florida Research Foundation, Inc. Method for using photoplethysmography to optimize fluid removal during renal replacement therapy by hemodialysis or hemofiltration
EP2068971B1 (en) 2006-09-19 2016-11-23 Gambro Lundia AB Estimation of propensity to symptomatic hypotension
GB0621452D0 (en) 2006-10-27 2006-12-06 Ucl Business Plc Therapy for liver disease
WO2008064174A1 (en) 2006-11-17 2008-05-29 National Quality Care, Inc. Enhanced clearance in an artificial kidney incorporating a pulsatile pump
ES2370985T3 (es) 2006-12-01 2011-12-26 Gambro Lundia Ab Aparato de tratamiento de sangre.
US20110247973A1 (en) 2006-12-08 2011-10-13 Ohio University Exfiltration apparatus
EP2114510A4 (en) 2006-12-19 2014-04-16 Arnold J Lande CHRONIC ACCESS SYSTEM FOR EXTRACORPOREAL TREATMENT OF BLOOD WITH A CONTINUOUSLY PORTABLE HEMODIALYSER
US9033908B2 (en) 2006-12-21 2015-05-19 Nederlandse Organisatie Voor Toegepast—Natuurwetenschappelijk Onderzoek Tno Device for the removal of toxic substances from blood
US9968266B2 (en) 2006-12-27 2018-05-15 Cardiac Pacemakers, Inc. Risk stratification based heart failure detection algorithm
US20080161751A1 (en) 2006-12-29 2008-07-03 Plahey Kulwinder S Peritoneal dialysis therapy validation
US8183046B2 (en) 2007-01-11 2012-05-22 The Board Of Trustees Of The University Of Illinois Temperature resistant pH buffers for use at low temperatures
US8888470B2 (en) 2007-02-27 2014-11-18 Deka Products Limited Partnership Pumping cassette
US8042563B2 (en) 2007-02-27 2011-10-25 Deka Products Limited Partnership Cassette system integrated apparatus
US8409441B2 (en) 2007-02-27 2013-04-02 Deka Products Limited Partnership Blood treatment systems and methods
MX357266B (es) 2007-02-27 2018-07-03 Deka Products Lp Sistemas y metodos de hemodialisis.
US8357298B2 (en) 2007-02-27 2013-01-22 Deka Products Limited Partnership Hemodialysis systems and methods
US7906085B2 (en) 2007-03-30 2011-03-15 Battelle Memorial Institute Fast-regenerable sulfur dioxide adsorbents for diesel engine emission control
WO2008125894A1 (en) 2007-04-12 2008-10-23 Gambro Lundia Ab Apparatus for extracorporeal blood treatment
PL2142234T3 (pl) 2007-04-12 2013-06-28 Gambro Lundia Ab Sposób i urządzenie do zalewania pozaustrojowego obiegu krwi
ATE477824T1 (de) 2007-06-20 2010-09-15 Braun B Avitum Ag Vorrichtung zur bestimmung des reduktionsverhältnisses oder des kt/v- verhältnisses einer nierenersatzbehandlung
US7901376B2 (en) 2007-07-05 2011-03-08 Baxter International Inc. Dialysis cassette having multiple outlet valve
PT2765139T (pt) 2007-07-20 2017-07-14 Mayo Foundation Polipéptidos natriuréticos
US7981082B2 (en) 2007-08-21 2011-07-19 Hospira, Inc. System and method for reducing air bubbles in a fluid delivery line
AT505690B1 (de) 2007-08-31 2012-09-15 Zentrum Fuer Biomedizinische Technologie Der Donau Uni Krems Verfahren zum erfassen der ionenkonzentration bei citrat-antikoagulierter extrakorporaler blutreinigung
US20090101577A1 (en) 2007-09-28 2009-04-23 Fulkerson Barry N Methods and Systems for Controlling Ultrafiltration Using Central Venous Pressure Measurements
US8597505B2 (en) 2007-09-13 2013-12-03 Fresenius Medical Care Holdings, Inc. Portable dialysis machine
US9199022B2 (en) 2008-09-12 2015-12-01 Fresenius Medical Care Holdings, Inc. Modular reservoir assembly for a hemodialysis and hemofiltration system
US8105487B2 (en) 2007-09-25 2012-01-31 Fresenius Medical Care Holdings, Inc. Manifolds for use in conducting dialysis
US20090084199A1 (en) 2007-09-28 2009-04-02 Wright James E Quick-change sorbent trap module and method
US7892331B2 (en) 2007-10-01 2011-02-22 Baxter International Inc. Dialysis systems having air separation chambers with internal structures to enhance air removal
US20090120864A1 (en) 2007-10-05 2009-05-14 Barry Neil Fulkerson Wearable dialysis methods and devices
US8771508B2 (en) 2008-08-27 2014-07-08 Deka Products Limited Partnership Dialyzer cartridge mounting arrangement for a hemodialysis system
US7905853B2 (en) 2007-10-30 2011-03-15 Baxter International Inc. Dialysis system having integrated pneumatic manifold
US9415150B2 (en) 2007-11-09 2016-08-16 Baxter Healthcare S.A. Balanced flow dialysis machine
AU2008322546B2 (en) 2007-11-16 2013-10-03 Fresenius Medical Care Holdings, Inc. Dialysis systems and methods
US8889004B2 (en) 2007-11-16 2014-11-18 Fresenius Medical Care Holdings, Inc. Dialysis systems and methods
CN101883594B (zh) 2007-12-03 2012-10-10 Hepa净化有限公司 透析液再生单元
EP2237851B1 (en) 2008-01-18 2019-03-20 Fresenius Medical Care Holdings, Inc. Degassing device for carbon dioxide gas removal from a fluid circuit of a dialysis device
CA2712947C (en) 2008-01-23 2017-07-25 Deka Products Limited Partnership Fluid volume determination for medical treatment system
US7687041B2 (en) 2008-02-27 2010-03-30 Kellogg Brown & Root Llc Apparatus and methods for urea production
US8019406B2 (en) 2008-03-10 2011-09-13 Biotronik Crm Patent Ag Apparatus and method to assess the risk of R-on-T event
CN102046234A (zh) 2008-03-28 2011-05-04 阿兰德拉医药公司 液体麻醉药剂盒和蒸发器
WO2009132839A1 (en) 2008-04-30 2009-11-05 Gambro Lundia Ab Hydrophobic deaeration membrane
US8233973B2 (en) 2008-05-02 2012-07-31 Spacelabs Healthcare, Llc Methods for detection of cardiac arrhythmias
US8882700B2 (en) 2008-05-02 2014-11-11 Baxter International Inc. Smart patient transfer set for peritoneal dialysis
US8220643B2 (en) 2008-06-06 2012-07-17 Fresenius Medical Care Holdings, Inc. Urea sorbent
ES2821448T3 (es) 2008-06-23 2021-04-26 Temasek Polytechnic Sorbente para un dispositivo de diálisis
US9821105B2 (en) 2008-07-01 2017-11-21 Baxter International Inc. Nanoclay sorbents for dialysis
JP5172508B2 (ja) 2008-07-09 2013-03-27 株式会社ジャパンディスプレイセントラル 液晶表示装置
US8057679B2 (en) 2008-07-09 2011-11-15 Baxter International Inc. Dialysis system having trending and alert generation
US10265454B2 (en) 2008-07-25 2019-04-23 Baxter International Inc. Dialysis system with flow regulation device
US8696626B2 (en) 2008-07-30 2014-04-15 Claudia F. E. Kirsch Debubbler
CN102387982B (zh) 2008-08-28 2014-09-17 德卡产品有限公司 产品配制系统
US20100051552A1 (en) 2008-08-28 2010-03-04 Baxter International Inc. In-line sensors for dialysis applications
EP2163272B1 (en) 2008-09-15 2014-06-25 B. Braun Avitum AG Device to early predict the Kt/V parameter in kidney substitution treatments
WO2010039384A2 (en) 2008-09-30 2010-04-08 Fresenius Medical Care Holdings, Inc. Covalently immobilized enzyme and method to make the same
US8409444B2 (en) 2008-09-30 2013-04-02 Fresenius Medical Care Holdings, Inc. Acid zirconium phosphate and alkaline hydrous zirconium oxide materials for sorbent dialysis
AU2009298636B2 (en) 2008-10-03 2013-12-05 Fresenius Medical Care Holdings, Inc. Zirconium phosphate particles having improved adsorption capacity and method of synthesizing the same
US8206591B2 (en) 2008-10-16 2012-06-26 Fresenius Medical Care Holdings, Inc. Method of removing protein-bound deleterious substances during extracorporeal renal replacement treatment
CN101725811A (zh) 2008-10-24 2010-06-09 鸿富锦精密工业（深圳）有限公司 支撑装置
US7927392B2 (en) 2008-10-28 2011-04-19 Bha Group, Inc. Twist and lock connection for pleated filter element with flange-to-flange locking means
JP5551709B2 (ja) 2008-11-03 2014-07-16 フレゼニウス メディカル ケア ホールディングス インコーポレイテッド 携帯型腹膜透析システム
US8182673B2 (en) 2009-01-29 2012-05-22 Baxter International Inc. Drain and fill logic for automated peritoneal dialysis
US8377012B2 (en) 2009-01-30 2013-02-19 Baxter International Inc. Transfer sets for therapy optimization
CA2754522C (en) 2009-03-06 2019-08-20 Baxter International Inc. Hemodialysis and peritoneal dialysis systems having electrodeionization capabilities
US20100312174A1 (en) 2009-06-06 2010-12-09 Hoffman Josef C A Peritoneal Dialysis System
US20100312172A1 (en) 2009-06-06 2010-12-09 Hoffman Josef C A Method of Peritoneal Dialysis
US8080161B2 (en) 2009-06-11 2011-12-20 Baxter International Inc. Dialysis treatment devices for removing urea
EP3178387A1 (en) 2009-06-26 2017-06-14 Gambro Lundia AB Devices, a computer program product and a method for data extraction
AU2010266335A1 (en) 2009-07-01 2012-02-02 Board Of Regents, The University Of Texas System Methods of determining the presence and/or concentration of an analyte in a sample
US8180574B2 (en) 2009-07-07 2012-05-15 Baxter International Simplified peritoneal equilibration test for peritoneal dialysis
AU2010279725B2 (en) 2009-08-04 2014-10-02 Fresenius Medical Care Holdings, Inc. Dialysis systems, components, and methods
US8404091B2 (en) 2009-08-27 2013-03-26 Baxter International Inc. Dialysis treatment devices for removing urea
US20110066043A1 (en) 2009-09-14 2011-03-17 Matt Banet System for measuring vital signs during hemodialysis
US9399091B2 (en) 2009-09-30 2016-07-26 Medtronic, Inc. System and method to regulate ultrafiltration
US8518260B2 (en) 2009-10-01 2013-08-27 Fresenius Medical Care Holdings, Inc. Method of controlling diffusive sodium transport in dialysis
US20110130666A1 (en) 2009-11-30 2011-06-02 Yanting Dong Enhanced reporting of pathological episodes
MX341036B (es) 2009-12-07 2016-08-04 Fresenius Medical Care Holdings Inc Cartucho para purificacion de agua que usa sorbentes de intercambio ionico de zirconio.
US10980431B2 (en) 2009-12-28 2021-04-20 Gambro Lundia Ab Apparatus and method for prediction of rapid symptomatic blood pressure decrease
AU2011204267B2 (en) 2010-01-08 2015-12-03 Zafgen Corporation Fumagillol type compounds and methods of making and using same
JP5442483B2 (ja) 2010-02-10 2014-03-12 日機装株式会社 血液浄化装置
CN102190336B (zh) 2010-03-08 2014-11-26 周耀周 流体处理单元、流体处理组件以及流体处理装置
US8425780B2 (en) 2010-03-11 2013-04-23 Fresenius Medical Care Holdings, Inc. Dialysis system venting devices and related systems and methods
DE102010003642A1 (de) 2010-03-15 2011-09-15 Fresenius Medical Care Deutschland Gmbh Kassette mit einem Sensor zur Bestimmung der Differenz eines ersten und eines zweiten Flüssigkeitsstroms
JP5548001B2 (ja) 2010-03-25 2014-07-16 日機装株式会社 血液浄化装置
DE102010014785A1 (de) 2010-04-13 2011-10-13 Fresenius Medical Care Deutschland Gmbh Mehrschichtfolie, Verwendung einer Mehrschichtfolie und Verfahren zur Herstellung einer Mehrschichtfolie
US9132219B2 (en) 2010-04-16 2015-09-15 Baxter International Inc. Therapy prediction and optimization of serum potassium for renal failure blood therapy, especially home hemodialysis
WO2011140268A2 (en) 2010-05-04 2011-11-10 C-Tech Biomedical, Inc. Dual mode hemodialysis machine
WO2011140389A2 (en) 2010-05-05 2011-11-10 C-Tech Biomedical, Inc. Membrane electrolyzer and hemodialysis system using the same
DE102010020838A1 (de) 2010-05-18 2011-11-24 Fresenius Medical Care Deutschland Gmbh Ventilanordnung zur Verwendung in einem extrakorporalen Blutkreislauf sowie Verfahren
US9145318B2 (en) 2010-05-24 2015-09-29 Baxter International Inc. Systems and methods for removing hydrogen peroxide from water purification systems
US20110315632A1 (en) 2010-05-24 2011-12-29 Freije Iii William F Membrane filtration system
DE102010023635A1 (de) 2010-06-14 2011-12-15 Fresenius Medical Care Deutschland Gmbh Vorrichtung und Verfahren zum Fördern von Flüssigkeiten in die Behandlungseinheit einer medizinischen Behandlungsvorrichtung, insbesondere in den Dialysator einer Dialysevorrichtung
AU2011276036B2 (en) 2010-07-05 2014-05-22 Gambro Lundia Ab An ambulatory ultrafiltration device, related methods and a computer program product
US8784668B2 (en) 2010-10-12 2014-07-22 Fresenius Medical Care Holdings, Inc. Systems and methods for compensation of compliant behavior in regenerative dialysis systems
DE102010042637A1 (de) 2010-10-19 2012-04-19 Endress + Hauser Conducta Gesellschaft für Mess- und Regeltechnik GmbH + Co. KG Leitfähigkeitssensor
US8404491B2 (en) 2010-10-29 2013-03-26 Hewlett-Packard Development Company, L.P. Luminescent chemical sensor integrated with at least one molecular trap
EP2446908B1 (en) 2010-11-02 2015-07-15 ICinnovation BV Electrosorption and decomposition device for the purification of blood and other fluids
EP2654825B1 (en) 2010-12-20 2017-08-02 Fresenius Medical Care Holdings, Inc. Medical fluid cassettes and related systems and methods
EP2678028A2 (en) 2011-02-25 2014-01-01 Medtronic, Inc. Systems and methods for therapy of kidney disease and/or heart failure using chimeric natriuretic peptides
US9161675B2 (en) 2011-03-09 2015-10-20 Bsh Home Appliances Corporation Household appliance including information light device
ITMI20110441A1 (it) 2011-03-21 2012-09-22 Gambro Lundia Ab Apparecchiatura per il trattamento extracorporeo di sangue.
US8945936B2 (en) 2011-04-06 2015-02-03 Fresenius Medical Care Holdings, Inc. Measuring chemical properties of a sample fluid in dialysis systems
WO2013012463A1 (en) 2011-04-08 2013-01-24 Life Technologies Corporation AUTOMATED ON-INSTRUMENT pH ADJUSTMENT
EP2701580B1 (en) 2011-04-29 2020-12-30 Medtronic, Inc. Device to monitor patients with kidney disease
US9848778B2 (en) 2011-04-29 2017-12-26 Medtronic, Inc. Method and device to monitor patients with kidney disease
WO2012148781A1 (en) 2011-04-29 2012-11-01 Medtronic, Inc. Multimodal dialysis system
US9320842B2 (en) 2011-04-29 2016-04-26 Medtronic, Inc. Multimodal dialysis system
US9456755B2 (en) 2011-04-29 2016-10-04 Medtronic, Inc. Method and device to monitor patients with kidney disease
US9132217B2 (en) 2011-04-29 2015-09-15 Medtronic, Inc. Multimodal dialysis system
US8926542B2 (en) 2011-04-29 2015-01-06 Medtronic, Inc. Monitoring fluid volume for patients with renal disease
US20120303079A1 (en) 2011-05-23 2012-11-29 Deepa Mahajan Apparatus and method for combined cardiac function management and renal therapies
SG195155A1 (en) 2011-05-24 2013-12-30 Deka Products Lp Blood treatment systems and methods
EP3205362B1 (en) 2011-05-24 2022-07-06 DEKA Products Limited Partnership Hemodialysis system
US20130019179A1 (en) 2011-07-14 2013-01-17 Digilink Software, Inc. Mobile application enhancements
WO2013015858A1 (en) 2011-07-26 2013-01-31 Eveready Battery Company, Inc. Hydrogen generator with improved fluid distribution
DE102011052188A1 (de) 2011-07-27 2013-01-31 Maquet Vertrieb Und Service Deutschland Gmbh Anordnung zum Erwärmen und/oder Befeuchten des Spülgases eines Oxygenerators
DE102011108787A1 (de) 2011-07-29 2013-01-31 Fresenius Medical Care Deutschland Gmbh Medizinischer Port, Blutschlauch zur Verwendung bei einer extrakorporalen Blutbehandlung sowie medizinische Behandlungsvorrichtung
US20130030356A1 (en) 2011-07-29 2013-01-31 Baxter Healthcare S.A. Sodium management for dialysis systems
DE102011108786A1 (de) 2011-07-29 2013-01-31 Fresenius Medical Care Deutschland Gmbh Verfahren zum Ermitteln wenigstens eines Parameters eines extrakorporalen Blutkreislaufs sowie Vorrichtungen
MX339595B (es) 2011-07-29 2016-06-01 Baxter Int Manejo de sodio para sistemas de dialisis.
EP2739325B1 (en) 2011-08-02 2017-10-04 Medtronic, Inc. Hemodialysis system having a flow path with a controlled compliant volume
US20130037142A1 (en) 2011-08-08 2013-02-14 Fresenius Medical Care Holdings, Inc. Dialysis system having peristaltic pump arrangement
WO2013022024A1 (ja) 2011-08-09 2013-02-14 川澄化学工業株式会社 血液浄化装置
US10857277B2 (en) 2011-08-16 2020-12-08 Medtronic, Inc. Modular hemodialysis system
JP5903163B2 (ja) 2011-08-18 2016-04-13 フレセニウス メディカル ケア ホールディングス インコーポレーテッド 透析液の吸着剤および化学的再生
WO2013027214A2 (en) 2011-08-22 2013-02-28 Bar-Ilan University Nanop article dialysis
EP2747808B1 (en) 2011-08-22 2016-11-30 Medtronic Inc. Dual flow sorbent cartridge
ES2497215T3 (es) 2011-08-30 2014-09-22 Gambro Lundia Ab Aparato médico para tratamiento extracorpóreo de fluido y procedimiento de cálculo de caudales establecidos en un aparato médico para el aporte o la toma de fluidos
EP2564885B1 (en) 2011-08-30 2014-06-11 Gambro Lundia AB Apparatus for extracorporeal treatment of blood and process of calculating set flow rates in a medical apparatus for delivery or collection of fluids
DE102011053200A1 (de) 2011-09-01 2013-03-07 Fresenius Medical Care Deutschland Gmbh Dialysatfluss-Regelung
JP5099464B1 (ja) 2011-12-29 2012-12-19 富田製薬株式会社 重炭酸イオン濃度可変型の透析液の調製装置及び調製方法、重炭酸イオン濃度可変型の透析剤、並びに重炭酸イオン濃度可変型の透析システム
WO2013101888A1 (en) 2011-12-29 2013-07-04 Fresenius Medical Care Holdings, Inc. Materials for removal of toxins in sorbent dialysis and methods and systems using same
EP2800592B1 (en) 2012-01-04 2019-03-06 Medtronic Inc. Multi-staged filtration system for blood fluid removal
US9616163B2 (en) 2012-01-04 2017-04-11 Fresenius Medical Care Holdings, Inc. Method and system of enhancing removal of toxic anions and organic solutes in sorbent dialysis
EP2804640B1 (en) 2012-01-19 2016-01-13 Baxter International Inc Method and composition for removing uremic toxins in dialysis processes
US10076597B2 (en) 2012-02-02 2018-09-18 Quanta Fluid Systems Ltd. Dialysis machine
WO2013121162A1 (en) 2012-02-14 2013-08-22 Quanta Fluid Solutions Ltd Dialysis machine
JP5629714B2 (ja) 2012-03-19 2014-11-26 トヨタ自動車株式会社 半導体装置
US9610392B2 (en) 2012-06-08 2017-04-04 Fresenius Medical Care Holdings, Inc. Medical fluid cassettes and related systems and methods
US9500188B2 (en) 2012-06-11 2016-11-22 Fresenius Medical Care Holdings, Inc. Medical fluid cassettes and related systems and methods
US9231692B2 (en) 2012-09-04 2016-01-05 Viasat Inc. Paired-beam transponder satellite communication
US9138520B2 (en) 2012-10-22 2015-09-22 Baxter International Inc. Total chlorine water detection system and method for medical fluid treatments
US9162021B2 (en) 2012-10-22 2015-10-20 Baxter International Inc. Integrated water testing system and method for ultra-low total chlorine detection
JP2014097224A (ja) 2012-11-15 2014-05-29 Tatsunori Kato 透析ユニットおよびアクセス再循環率の測定方法
US10905816B2 (en) 2012-12-10 2021-02-02 Medtronic, Inc. Sodium management system for hemodialysis
US20140158588A1 (en) 2012-12-10 2014-06-12 Medtronic, Inc. pH AND BUFFER MANAGEMENT SYSTEM FOR HEMODIALYSIS SYSTEMS
US9399090B2 (en) 2012-12-10 2016-07-26 Medtronic, Inc. Potassium loaded ion-exchange material for use in a dialysate regeneration system
US9713666B2 (en) 2013-01-09 2017-07-25 Medtronic, Inc. Recirculating dialysate fluid circuit for blood measurement
US11154648B2 (en) 2013-01-09 2021-10-26 Medtronic, Inc. Fluid circuits for sorbent cartridge with sensors
US11565029B2 (en) 2013-01-09 2023-01-31 Medtronic, Inc. Sorbent cartridge with electrodes
US9707328B2 (en) 2013-01-09 2017-07-18 Medtronic, Inc. Sorbent cartridge to measure solute concentrations
US9526822B2 (en) 2013-02-01 2016-12-27 Medtronic, Inc. Sodium and buffer source cartridges for use in a modular controlled compliant flow path
US10010663B2 (en) 2013-02-01 2018-07-03 Medtronic, Inc. Fluid circuit for delivery of renal replacement therapies
WO2014121162A1 (en) 2013-02-01 2014-08-07 Medtronic, Inc. Sorbent cartridge to measure solute concentrations
US9827361B2 (en) 2013-02-02 2017-11-28 Medtronic, Inc. pH buffer measurement system for hemodialysis systems
US9144640B2 (en) 2013-02-02 2015-09-29 Medtronic, Inc. Sorbent cartridge configurations for improved dialysate regeneration
US9410255B2 (en) 2013-03-14 2016-08-09 Tennant Company System and method for generating and dispensing sodium hydroxide solutions
US20150057602A1 (en) 2013-08-26 2015-02-26 Roger Alan Mason System and Method for Administering Peritoneal Dialysis
US9707329B2 (en) 2013-10-23 2017-07-18 Fresenius Medical Care Holdings, Inc. Process for regeneration of spent zirconium phosphate for reuse in sorbent treatments
US10004839B2 (en) 2013-11-26 2018-06-26 Medtronic, Inc. Multi-use sorbent cartridge
US10052612B2 (en) 2013-11-26 2018-08-21 Medtronic, Inc. Zirconium phosphate recharging method and apparatus
US9981245B2 (en) 2013-11-26 2018-05-29 Medtronic, Inc. Method and apparatus for zirconium oxide recharging
US9943780B2 (en) 2013-11-26 2018-04-17 Medtronic, Inc. Module for in-line recharging of sorbent materials with optional bypass
US9974896B2 (en) 2014-06-24 2018-05-22 Medtronic, Inc. Method of zirconium phosphate recharging
US9895477B2 (en) 2013-11-26 2018-02-20 Medtronic, Inc. Detachable module for recharging sorbent materials with optional bypass
US9884145B2 (en) 2013-11-26 2018-02-06 Medtronic, Inc. Parallel modules for in-line recharging of sorbents using alternate duty cycles
US10099215B2 (en) 2013-11-26 2018-10-16 Medtronic, Inc. Management of recharger effluent pH
US10099214B2 (en) 2013-11-26 2018-10-16 Medtronic, Inc. Zirconium phosphate and zirconium oxide recharger control logic and operational process algorithms
US10052624B2 (en) 2013-11-26 2018-08-21 Medtronic, Inc. Zirconium phosphate and zirconium oxide recharging flow paths
US10159957B2 (en) 2013-11-26 2018-12-25 Medtronic, Inc. Zirconium phosphate recharging customization
US10537875B2 (en) 2013-11-26 2020-01-21 Medtronic, Inc. Precision recharging of sorbent materials using patient and session data
US10064986B2 (en) 2013-11-26 2018-09-04 Medtronic, Inc. Recharger for recharging zirconium phosphate and zirconium oxide modules
CN106029119B (zh) 2014-02-19 2018-10-09 美敦力公司 用于在线再装填吸附剂材料的模块与任选的旁路
US9764073B2 (en) 2014-02-26 2017-09-19 Medtronic, Inc. Authentication and tracking system
CA2935791C (en) 2014-03-17 2018-02-27 Fresenius Medical Care Holdings, Inc. Cartridges useful in cleaning dialysis solutions
CN106659827B (zh) 2014-06-24 2019-07-09 美敦力公司 使用脲酶袋补充透析系统中的脲酶
EP3160534A4 (en) 2014-06-24 2018-03-07 Medtronic Inc. Stacked sorbent assembly
EP3160535A4 (en) 2014-06-24 2018-03-07 Medtronic Inc. Modular dialysate regeneration assembly
WO2015199761A1 (en) 2014-06-24 2015-12-30 Medtronic, Inc. Sorbent pouch
EP3160531B1 (en) 2014-06-24 2019-08-14 Medtronic Inc. Replenisihing urease in dialysis systems using a urease introducer
US10004838B2 (en) 2014-06-24 2018-06-26 Medtronic, Inc. Reserve zirconium phosphate module for use in sorbent dialysis
WO2015199763A1 (en) 2014-06-24 2015-12-30 Medtronic, Inc. A urease introduction system for replenishing urease in a sorbent cartridge
WO2016191041A1 (en) 2015-05-26 2016-12-01 Medtronic, Inc. Zirconium phosphate and zirconium oxide recharging flow paths
EP3302609B1 (en) 2015-05-26 2019-10-09 Medtronic Inc. Recharger for recharging zirconium phosphate and zirconium oxide modules
US10981148B2 (en) * 2016-11-29 2021-04-20 Medtronic, Inc. Zirconium oxide module conditioning
US20180361355A1 (en) * 2017-06-15 2018-12-20 Medtronic, Inc. Zirconium oxide disinfection recharging and conditioning
EP3546042A1 (en) 2018-03-30 2019-10-02 Medtronic, Inc. Precision recharging of sorbent materials using patient and session data
US20200086297A1 (en) 2018-09-19 2020-03-19 Medtronic, Inc. Precision recharging based on sorbent effluent analysis

Also Published As

Publication number Publication date
CN108159733A (zh) 2018-06-15
US11642654B2 (en) 2023-05-09
EP3326668A1 (en) 2018-05-30
US10981148B2 (en) 2021-04-20
CA2986121A1 (en) 2018-05-29
US20210187481A1 (en) 2021-06-24
EP3326668B1 (en) 2020-03-11
US20180147558A1 (en) 2018-05-31

Similar Documents

Publication Publication Date Title
CN108159733B (zh) 氧化锆模块调节
CN109225178B (zh) 磷酸锆再充方法和设备
EP3302609B1 (en) Recharger for recharging zirconium phosphate and zirconium oxide modules
US10064986B2 (en) Recharger for recharging zirconium phosphate and zirconium oxide modules
US10099215B2 (en) Management of recharger effluent pH
US10159957B2 (en) Zirconium phosphate recharging customization
EP3546042A1 (en) Precision recharging of sorbent materials using patient and session data
US10537875B2 (en) Precision recharging of sorbent materials using patient and session data
EP3302610B1 (en) Zirconium phosphate and zirconium oxide recharging flow paths
US11883794B2 (en) Zirconium phosphate disinfection recharging and conditioning
EP3326712B1 (en) Zirconium phosphate recharging customization
US11213616B2 (en) Recharge solution for zirconium phosphate
EP3415183A2 (en) Zirconium oxide disinfection recharging and conditioning
EP3623042B1 (en) Recharge solution for zirconium oxide
CN107660161B (zh) 再装填器流出物pH值的管理

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant